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Indira  Kudva    Research Microbiologist  **Dr. Indira T. Kudva******Research MicrobiologistUSDA-ARS, National Animal Disease CenterFood Safety and Enteric Pathogens Research UnitBldg. 20, 1 North, Room #11211920 Dayton Avenue, Ames, IA 50010.Email:indira.kudva@usda.govPhone: (515) 337-7376 **Degrees:**B.Sc. Stella Maris College, Chennai, India; Zoology; 1984M.Sc. Kasturba Medical College, Manipal, India; Medical Microbiology; 1987Ph.D. University of Idaho, Moscow, ID; Microbiology, Molecular Biology and Biochemistry; 1997 **Postdoctoral Fellowships:**University of Idaho, Moscow, ID; 1998Massachusetts General Hospital and Harvard Medical School, Boston, MA; 2001 **Professional Appointments:**Diagnostic Laboratory Manager, St. John’s Medical College Hospital, India; 1988-1992 Instructor in Medicine, Harvard Medical School and Massachusetts General Hospital,Boston, MA; 2001-2007 Consultant and Owner, Microbianome, Newberry, FL; 2008-2009 Research Microbiologist, USDA-ARS, NADC, Ames, IA; 2009-Current Affiliate Assistant Professor, Iowa State University, Ames, IA; 2014-2020 Affiliate Associate Professor, Iowa State University, Ames, IA; 2020-Current **Laboratory Personnel:**Scientific Support Technician: Mr. Bryan Wheeler, B.S. ORISE Postgraduate: Ms. Erika Biernbaum, M.S. **Research Interests and Projects:**Shiga toxin-producing Escherichia coli (STEC) are foodborne pathogens that can cause disease in humans ranging from diarrhea, bloody diarrhea or hemorrhagic colitis to the hemolytic uremic syndrome associated with kidney failure and death. Although several ruminants harbor STEC, cattle are considered to be the primary reservoirs for these bacteria, as most outbreaks have been linked, directly or indirectly, to bovine sources. STEC colonize the gastrointestinal tracts of cattle but the animals remain asymptomatic and disease-free. My current research is molded around the USDA mission to develop preharvest (before slaughter) strategies to control STEC in cattle in order to minimize 'farm to fork' contamination of food. Towards this end, I am using global (proteomics, metabolomics, microbiome analysis) and targeted (genetic, histological, cell and in vitro organ culture, animal study) technologies to analyze STEC colonization dynamics and identify key targets for therapeutic and diagnostic use. Projects in my laboratory address, (i) STEC interactions with the bovine gastrointestinal cells especially those at the recto-anal junction (RAJ), (ii) STEC factors that promote its survival in the bovine rumen and persistence at the RAJ, (iii) Adherence mechanisms deployed by STEC in strain and host-dependent manner, (iv) Development of rational vaccines and vaccine-alternatives that target STEC in cattle and (v) Development of diagnostic assays to study STEC adherence and to identify STEC-colonized cattle. **Recent Publications:** PubMed:http://www.ncbi.nlm.nih.gov/pubmed/?term=Kudva+I


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