ARS HomeMidwest AreaAmes, IowaNational Animal Disease CenterResearch

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**Collaborations**
The National Animal Disease Center has a long and productive history of collaborative research involving stakeholders.

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Current collaborators and projects:
                            In Vivo Evaluation of Avirulent Live B. Bronchiseptica Vaccine to Reduce PRDC Severity                        
                            Investigation of a PRNP Polymorphism on Susceptibility to Bovine Spongiform Encephalopathy (BSE)                        
                            Development and Testing of Mycobacterium Avium Subsp. Paratuberculosis Diva Vaccines in Dairy Cattle                        
                            Safe and Broadly Cross-Protective Live Attenuated Influenza Virus Vaccine for Use in Swine                        
                            Facilitated Expert Gap Analysis and Review of Contagious Bovine Pleuropneumonia (CBPP)                        
                            Development of a Transgenic Mouse that Expresses the Bovine Prion Polymorphism T231                        
                            Assessing the Potential Transmissibility of Bovine and Cervid Prions with a Human Prion Protein-based Model                        
                            The Study of Influenza A Viruses in the Swine Host                        
                            The Study of Influenza A Viruses in the Swine Host                        
                            Revealing Mechanisms for Internal Salmonella Colonization and Persistence in Porcine Lymphoid and Fat Tissues                        
                            Evolution of Influenza A Virus in Swine in Brazil                        
                            Efficacy of a Pan-genotypic Influenza A Virus Antisense Locked Nucleic Acid Oligonucleotide (LNA) as a Preventative and Therapeutic in Swine                        
                            Generation of a Transposon Mutant Library of Mycoplasma Mycoides Subspecies Mycoides                        
                            Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals                        
                            Development of Wireless Sensors for Detecting Misfolded Prion Proteins and Rumen pH of Deer                        
                            Development of a Mucosal, Polyanhydride-based Nanoparticle Vaccine for Use Against Respiratory Syncytial Virus Infection in the Neonate                        
                            Online Algorithms to Identify Reassortment and Genetic Novelty in Genomic Influenza A Virus Surveillance Data                        
                            Algorithms to Identify Novel Influenza A Viruses in Genomic Surveillance Data                        
                            Computational Analysis of Host, Bacteria, and Microbiome for Development of Strategies to Enhance Health and Food Safety                        
                            Characterization of Influenza at the Human and Swine Interface                        
                            Continued Development of an Immunological Toolkit and Profile for Bottlenose Dolphins                        
                            Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals                        
                            Continued Development of an Immunological Toolkit and Profile for Bottlenose Dolphins                        
                            Pathogenesis of Swine Acute Diarrhea Syndrome Coronavirus                        
                            Defining Antagonism Hierarchy of Porcine Epidemic Diarrhea Virus for Live Vaccines Design                        
                            mRNA-LNP Vaccines for Pandemic Preparedness                        
                            NIAID Centers of Excellence for Influenza Research and Response                        
                            Host-pathogen Interactions and Control Strategies for Bacterial Respiratory Pathogens in Cattle                        
                            Transmission Bottlenecks and Within-host Evolutionary Dynamics of Influenza A Virus                        
                            Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resistance in Animals                        
                            16S Metagenomic Sequencing Analysis                        
                            Assessment of Biochar- Chronic Wasting Disease Interactions and the Feasibility of Using Biochar to Reduce Spread of Chronic Wasting Disease                        
                            Development and Validation of TB Diagnostics for Deer and Cattle that have been Vaccinated with BCG                        
                            TB Diagnostics in Vaccinated Cattle and Deer                        
                            Severe acute Respiratory Syndrome Coronavirus-2 Research Priorities                        
                            SARS-CoV-2 White-tailed Deer Infection Dynamics and Antibody Persistence                        
                            Experimental Infections of Elk With SARS-CoV-2                        
                            Characterization of Virus Isolates from the USDA Swine Influenza A Virus Surveillance System                        
                            USDA Influenza A Virus in Swine Surveillance System – Genomic Epidemiology and Evolution