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                    U.S. DEPARTMENT OF AGRICULTURE
 Animal Disease Research: Pullman, WA
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ARS Home Pacific West Area Pullman, Washington Animal Disease Research People & Locations







David R Herndon
                        Animal Disease Research

                        




                        
                        Geneticist
                        Phone: (509) 335-6004
                        
                        
                        Fax: (509) 335-8328(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            ProjectsGenetic Approaches and Tools to Prevent, Control, and Eradicate Transmissible Spongiform Encephalopathies
                                                    In-House Appropriated
                                                                    (D)Accession Number: 441236Control Strategies for Theileriosis
                                                    In-House Appropriated
                                                                    (D)Accession Number: 441269Development of a Vaccine and Improved Diagnostics for Malignant Catarrhal Fever
                                                    In-House Appropriated
                                                                    (D)Accession Number: 441300Understanding Host-Bacterial Interactions to Mitigate Disease in Small Ruminants
                                                    In-House Appropriated
                                                                    (D)Accession Number: 443841Advanced Host Genomics: Nasal Shedding of Mycoplasma Ovipneumoniae and Multiple Data Uses to Benefit Sheep Research
                                                    Non-Assistance Cooperative Agreement
                                                                    (S)Accession Number: 439061**Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)Coding complete genome of a strain of ovine herpesvirus-2 associated with a clinical case of malignant catarrhal fever in a domestic lamb
                                                        

- (Peer Reviewed Journal)Herndon, D.R., Herndon, M.K., Cunha, C.W. 2024. Coding complete genome of a strain of ovine herpesvirus-2 associated with a clinical case of malignant catarrhal fever in a domestic lamb. Microbiology Resource Announcements. https://doi.org/10.1128/mra.01107-23.Dermacentor variabilis does not transstadially transmit the U.S. Isolate of Theileria orientalis Ikeda: A controlled acquisition and transmission study
                                                        

- (Peer Reviewed Journal)Onzere, C.K., Hassan, A., Herndon, D.R., Oyen, K.J., Poh, K.C., Scoles, G.A., Fry, L.M. 2023. Dermacentor variabilis does not transstadially transmit the U.S. Isolate of Theileria orientalis Ikeda: A controlled acquisition and transmission study. Parasitologia. 3(3):284-292. https://doi.org/10.3390/parasitologia3030029.A U.S. isolate of Theileria orientalis ikeda is not transstadially transmitted to cattle by Rhipicephalus microplus
                                                        

- (Peer Reviewed Journal)Onzere, C.K., Herndon, D.R., Hassan, A., Oyen, K.J., Poh, K.C., Scoles, G.A., Fry, L.M. 2023. A U.S. isolate of Theileria orientalis ikeda is not transstadially transmitted to cattle by Rhipicephalus microplus. Pathogens. 12(4). Article 559. https://doi.org/10.3390/pathogens12040559.Development of a real-time PCR assay for detection and differentiation of Mycoplasma ovipneumoniae and a novel respiratory-associated Mycoplasma species in domestic sheep and goats
                                                        

- (Peer Reviewed Journal)Noll, L.W., Highland, M.A., Hamill, V.A., Tsui, W., Porter, E.P., Lu, N., Sebhatu, T., Brown, S., Herndon, D.R., Grossman, P.C., Bai, J. 2022. Development of a real-time PCR assay for detection and differentiation of Mycoplasma ovipneumoniae and a novel respiratory-associated Mycoplasma species in domestic sheep and goats. Transboundary and Emerging Diseases. https://doi.org/10.1111/tbed.14477.Laboratory concordance study for the molecular detection of Mycoplasma ovipneumoniae
                                                        

- (Peer Reviewed Journal)Lieske, C.L., Herndon, D.R., Highland, M.A., Beckmen, K.F. 2022. Laboratory concordance study for the molecular detection of Mycoplasma ovipneumoniae. Journal of Wildlife Diseases. 58(2):257-268. https://doi.org/10.7589/JWD-D-21-00118.Both coinfection and superinfection drive complex Anaplasma marginale strain structure in a natural transmission setting
                                                        

- (Peer Reviewed Journal)Koku, R., Herndon, D.R., Avillan, J., Morrison, J., Futse, J.E., Palmer, G.H., Brayton, K.A., Noh, S.M. 2021. Both coinfection and superinfection drive complex Anaplasma marginale strain structure in a natural transmission setting. Infection and Immunity. 89(11). Article e00166-21. https://doi.org/10.1128/IAI.00166-21.Genes involved in immune, gene translation and chromatin organization pathways associated with Mycoplasma ovipneumoniae presence in nasal secretions of domestic sheep
                                                        

- (Peer Reviewed Journal)Mousel, M.R., White, S.N., Herndon, M.K., Herndon, D.R., Taylor, J.B., Becker, G.M., Murdoch, B.M. 2021. Genes involved in immune, gene translation and chromatin organization pathways associated with Mycoplasma ovipneumoniae presence in nasal secretions of domestic sheep. PLoS ONE. 16(7). Article e0247209. https://doi.org/10.1371/journal.pone.0247209.A U.S. isolate of Theileria orientalis, Ikeda genotype, is transmitted to cattle by the invasive Asian longhorned tick, Haemaphysalis longicornis
                                                        

- (Peer Reviewed Journal)Dinkel, K.D., Herndon, D.R., Noh, S.M., Lahmers, K.K., Todd, M.S., Ueti, M.W., Scoles, G.A., Mason, K.L., Fry, L.M. 2021. A U.S. isolate of Theileria orientalis, Ikeda genotype, is transmitted to cattle by the invasive Asian longhorned tick, Haemaphysalis longicornis. Parasites & Vectors. 14. Article 157. https://doi.org/10.1186/s13071-021-04659-9.Differential pulmonary immunopathology of domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) with Mycoplasma ovipneumoniae infection: a retrospective study
                                                        

- (Peer Reviewed Journal)Grossman, P.C., Schneider, D.A., Herndon, D.R., Knowles, D.P., Highland, M.A. 2021. Differential pulmonary immunopathology of domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) with Mycoplasma ovipneumoniae infection: a retrospective study. Comparative Immunology Microbiology and Infectious Diseases. 76. Article 101641. https://doi.org/10.1016/j.cimid.2021.101641.Draft genome sequence of a novel Mycoplasma species identified from the respiratory tract of an Alaska moose (Alces alces gigas)
                                                        

- (Peer Reviewed Journal)Herndon, D.R., Beckmen, K.B., Highland, M.A. 2021. Draft genome sequence of a novel Mycoplasma species identified from the respiratory tract of an Alaska moose (Alces alces gigas). Microbiology Resource Announcements. 10(8). Article e01371- 20. https://doi.org/10.1128/MRA.01371-20.Genome-wide histone modifications and CTCF enrichment predict gene expression in sheep macrophages
                                                        

- (Peer Reviewed Journal)Massa, A.T., Mousel, M.R., Herndon, M.K., Herndon, D.R., Murdoch, B.M., White, S.N. 2021. Genome-wide histone modifications and CTCF enrichment predict gene expression in sheep macrophages. Frontiers in Genetics. 11. Article 612031. https://doi.org/10.3389/fgene.2020.612031.Transcriptome dataset of Babesia bovis life stages within vertebrate and invertebrate hosts
                                                        

- (Peer Reviewed Journal)Ueti, M.W., Johnson, W.C., Kappmeyer, L.S., Herndon, D.R., Mousel, M.R., Reif, K.E., Taus, N.S., Ifeonu, O.O., Silva, J.C., Suarez, C.E., Brayton, K.A. 2020. Transcriptome dataset of Babesia bovis life stages within vertebrate and invertebrate hosts. Data in Brief. 33. Article 106533. https://doi.org/10.1016/j.dib.2020.106533.Comparative analysis of gene expression between Babesia bovis blood stages and kinetes allowed by improved genome annotation.
                                                        

- (Peer Reviewed Journal)Ueti, M.W., Johnson, W.C., Kappmeyer, L.S., Herndon, D.R., Mousel, M.R., Reif, K.E., Taus, N.S., Ifeonu, O.O., Silva, J.C., Suarez, C.E., Brayton, K.A. 2020. Comparative analysis of gene expression between Babesia bovis blood stages and kinetes allowed by improved genome annotation.. International Journal for Parasitology. 51(2-3):123-136. https://doi.org/10.1016/j.ijpara.2020.08.006.Mycoplasma ovis infection in domestic sheep (Ovis aries) in the United States: prevalence, distribution, associated risk factors, and associated outcomes
                                                        

- (Peer Reviewed Journal)Urie, N.J., Highland, M.A., Knowles, D.P., Brannan, M.A., Herndon, D.R., Marshall, K.L. 2019. Mycoplasma ovis infection in domestic sheep (Ovis aries) in the United States: prevalence, distribution, associated risk factors, and associated outcomes. Preventive Veterinary Medicine. 171. https://doi.org/10.1016/j.prevetmed.2019.104750.A recombinant bovine herpesvirus-4 vectored vaccine delivered via intranasal nebulization elicits viral neutralizing antibody titers in cattle
                                                        

- (Peer Reviewed Journal)Williams, L.B., Fry, L.M., Herndon, D.R., Franceschi, V., Schneider, D.A., Donofrio, G., Knowles, D.P. 2019. A recombinant bovine herpesvirus-4 vectored vaccine delivered via intranasal nebulization elicits viral neutralizing antibody titers in cattle. PLoS One. 14(4):e0215605. https://doi.org/10.1371/journal.pone.0215605.Identification of Mycoplasma ovipneumoniae in wildlife species beyond the subfamily caprinae
                                                        

- (Peer Reviewed Journal)Highland, M.A., Herndon, D.R., Bender, S., Hansen, L., Gerlach, R.F., Beckman, K.B. 2018. Identification of Mycoplasma ovipneumoniae in wildlife species beyond the subfamily caprinae. Emerging Infectious Diseases. 24(12):2384-2386. https://doi.org/10.3201/eid2412.180632.Discovery of a novel species Theileria haneyi n. sp. infective to equids highlights exceptional genomic diversity within the genus Theileria: implications for apicomplexan parasite surveillance
                                                        

- (Peer Reviewed Journal)Knowles, D.P., Kappmeyer, L.S., Haney, D., Herndon, D.R., Fry, L.M., Munro, J.B., Sears, K., Ueti, M.W., Wise, L.N., Silva, M., Schneider, D.A., Grause, J., White, S.N., Trentina, K., Bishop, R., Odongo, D.O., Pelzel-McCluske, A.M., Scoles, G.A., Mealey, R.H., Silva, J.C. 2018. Discovery of a novel species Theileria haneyi n. sp. infective to equids highlights exceptional genomic diversity within the genus Theileria: implications for apicomplexan parasite surveillance. International Journal for Parasitology. 48(9-10):127-137. https://doi.org/10.1016/j.ijpara.2018.03.010.The babesia bovis hap2 gene is not required for blood stage replication, but expressed upon in vitro sexual stage induction
                                                        

- (Peer Reviewed Journal)Hussein, H.E., Bastos, R.G., Schneider, D.A., Johnson, W.C., Adham, F.K., Davis, W.C., Laughery, J.M., Herndon, D.R., Alzan, H.F., Ueti, M.W., Suarez, C.E. 2017. The babesia bovis hap2 gene is not required for blood stage replication, but expressed upon in vitro sexual stage induction. PLOS Neglected Tropical Diseases. 11(10):e0005965. https://doi.org/10.1371/journal.pntd.0005965.Geno- and phenotypic characteristics of a transfected babesia bovis 6-Cys-E knockout clonal line

- (Peer Reviewed Journal)Alzan, A., Silva, M., Davis, W., Herndon, D.R., Schneider, D.A., Suarez, C.E. 2017. Geno- and phenotypic characteristics of a transfected babesia bovis 6-Cys-E knockout clonal line. Parasites & Vectors. 10(1):214.Expression of 6-Cys gene superfamily defines babesia bovis sexual stage development within rhipicephalus microplus

- (Peer Reviewed Journal)Alzan, H.F., Lau, A., Knowles, D.P., Herndon, D.R., Ueti, M.W., Scoles, G.A., Kappmeyer, L.S., Suarez, C.E. 2016. Expression of 6-Cys gene superfamily defines babesia bovis sexual stage development within rhipicephalus microplus. PLoS One. doi:10.1371/journal.pone.0163791.Ovine leukocyte profiles do not associate with variation in the prion gene, but are breed-dependent

- (Peer Reviewed Journal)Mousel, M.R., White, S.N., Herndon, D.R., Reynolds, J.O., Gonzalez, M., Johnson, W.C., Ueti, M.W., Taylor, J.B., Knowles Jr, D.P. 2015. Ovine leukocyte profiles do not associate with variation in the prion gene, but are breed-dependent. Animal Genetics. 47(1):136-37.Anaplasma marginale superinfection attributable to pathogen strains with distinct genomic backgrounds.

- (Peer Reviewed Journal)Vallejo, E., Herndon, D.R., Mendoza, F., Mosqueda, J., Palmer, G. 2014. Anaplasma marginale superinfection attributable to pathogen strains with distinct genomic backgrounds. Infection and Immunity. 82(12):5286-5292.Malignant catarrhal fever in American bison (Bison bison) experimentally infected with alcelaphine herpesvirus 2

- (Peer Reviewed Journal)Taus, N.S., O'Toole, D., Herndon, D.R., Cunha, C.W., Warg, J.V., Seal, B.S., Brooking, A., Li, H. 2014. Malignant catarrhal fever in American bison (Bison bison) experimentally infected with alcelaphine herpesvirus 2. Veterinary Microbiology. DOI:10.1016/j.vetmic.2014.04.003.A divergent artiodactyl MYADM-like repeat is associated with erythrocyte traits and weight of lamb weaned in domestic sheep

- (Peer Reviewed Journal)Gonzalez, M.V., Mousel, M.R., Herndon, D.R., Jiang, Y., Dalrymple, B.P., Reynolds, J.O., Johnson, W.C., Herrmann-Hoesing, L.M., White, S.N. 2013. A divergent artiodactyl MYADM-like repeat is associated with erythrocyte traits and weight of lamb weaned in domestic sheep. PLoS One. 8(8):e74700. doi: 10.1371/journal.pone.0074700.Identification of multi-locus genetic heterogeneity in anaplasma marginale ss. centrale and its restriction following tick-borne transmission.
                                                        

- (Peer Reviewed Journal)Herndon, D.R., Ueti, M.W., Reif, K.E., Noh, S.M., Brayton, K.A., Agnes, J.T., Palmer, G.H. 2013. Identification of multi-locus genetic heterogeneity in anaplasma marginale ss. centrale and its restriction following tick-borne transmission. Infection and Immunity. 81(5):1852-8.Comparative genomic analysis and phylogenetic position of Theileria equi
                                                        

- (Peer Reviewed Journal)Kappmeyer, L.S., Thiagarajan, M., Herndon, D.R., Ramsay, J.D., Caler, E., Djikeng, A., Gillespie, J.J., Lau, A.O., Roalson, E.H., Silva, J.C. 2012. Comparative genomic analysis and phylogenetic position of Theileria equi. Biomed Central (BMC) Genomics. BMC Genomics 2012, 13:603.Non-maternal transmission is the major mode of ovine lentivirus transmission in a ewe flock: A molecular epidemiology study

- (Peer Reviewed Journal)Broughton-Neiswanger, L.E., White, S.N., Knowles Jr, D.P., Mousel, M.R., Lewis, G.S., Herndon, D.R., Hoesing, L.M. 2010. Non-maternal transmission is the major mode of ovine lentivirus transmission in a ewe flock: A molecular epidemiology study. Infection, Genetics and Evolution. 10(7):998-1007.Association of pathogen strain-specific gene transcription and transmission efficiency phenotype of Anaplasma marginale

- (Peer Reviewed Journal)Agnes, J.T., Herndon, D.R., Ueti, M.W., Ramabu, S., Evans, M., Brayton, K.A., Palmer, G.H. 2010. Association of pathogen strain-specific gene transcription and transmission efficiency phenotype of Anaplasma marginale. Infection and Immunity. Available: http://iai.asm.org/cgi/reprint/IAI.00108-10v1Genome sequences of mannheimia haemolytica serotype A2: ovine and bovine isolates

- (Peer Reviewed Journal)Lawrence, P.K., Kittichotirat, W., Bumgarner, R.E., Mcdermott, J.E., Herndon, D.R., Knowles Jr, D.P., Srikumaran, S. 2010. Genome sequences of mannheimia haemolytica serotype A2: ovine and bovine isolates. Journal of Bacteriology. 192(4):1167-8.blaCMY-2-positive IncA/C plasmids from escherichia coli and salmonella enterica are a distinct component of a larger lineage of plasmids

- (Peer Reviewed Journal)Call, D.R., Singer, R.S., Meng, D., Broschat, S.L., Orfe, L.H., Anderson, J.M., Herndon, D.R., Kappmeyer, L.S., Daniels, J.B., Besser, T.E. 2010. blaCMY-2-positive IncA/C plasmids from escherichia coli and salmonella enterica are a distinct component of a larger lineage of plasmids. Antimicrobial Agents and Chemotherapy. 54(2):590-6.Complete Genome Sequence of Anaplasma marginale subsp. centrale

- (Peer Reviewed Journal)Herndon, D.R., Palmer, G.H., Shkap, V., Knowles Jr, D.P., Brayton, K.A. 2010. Complete Genome Sequence of Anaplasma marginale subsp. centrale. Journal of Bacteriology. 192(1):379-380.Conservation in the face of diversity: multistrain analysis of an intracellular bacterium

- (Peer Reviewed Journal)Dark, M.J., Herndon, D.R., Kappmeyer, L.S., Gonzales, M.P., Nordeen, E., Palmer, G.H., Knowles Jr, D.P., Brayton, K.A. 2009. Conservation in the face of diversity: multistrain analysis of an intracellular bacterium. Biomed Central (BMC) Genomics. 10:16.Genomic analysis of Ovis aries (Ovar)MHC Class IIa loci

- (Peer Reviewed Journal)Hoesing, L.M., White, S.N., Kappmeyer, L.S., Herndon, D.R., Knowles Jr, D.P. 2008. Genomic analysis of Ovis aries (Ovar)MHC Class IIa loci. Immunogenetics. 60(3):167-176.Association of Mycoplasma ovipneumoniae Infection with Population-Limiting Respiratory Disease in Free-Ranging Rocky Mountain Bighorn Sheep (Ovis canadensis canadensis)

- (Peer Reviewed Journal)Besser, T.E., Cassirer, K.A., Potter, K.A., Vanderschalie, J., Fischer, A., Knowles Jr, D.P., Herndon, D.R., Rurangirwa, F.R., Weiser, G.C., Srikumaran, S. 2008. Association of Mycoplasma ovipneumoniae Infection with Population-Limiting Respiratory Disease in Free-Ranging Rocky Mountain Bighorn Sheep (Ovis canadensis canadensis). Journal of Clinical Microbiology. 46(2):423-430.Genome Sequence of Babesia bovis and Camparative Analysis of Apicomplexan Hemoprotozoa

- (Peer Reviewed Journal)Brayton, K., Lau, A.O., Herndon, D.R., Hannick, L., Kappmeyer, L.S., Berens, S.J., Bidwell, S.L., Brown, W.C., Crabtree, J., Fadrosh, D., Feldblum, T., Forberger, H.A., Haas, B.J., Howell, J.M., Khouri, H., Koo, H., Mann, D.J., Norimine, J., Paulsen, I.T., Radune, D., Ren, Q., Smith, R.K., Suarez, C.E., White, O., Wortman, J.R., Knowles Jr, D.P., Mcelwain, T.F., Nene, V.M. 2007. Genome Sequence of Babesia bovis and Camparative Analysis of Apicomplexan Hemoprotozoa. PLoS Pathogens. 3(10):1401-1413.COMPARISON OF OVINE HERPESVIRUS 2 GENOMES ISOLATED FROM DOMESTIC SHEEP (OVIS ARIES) AND A CLINICALLY AFFECTED COW (BOS BOVIS)

- (Peer Reviewed Journal)Taus, N.S., Herndon, D.R., Traul, D., Stewart, J.P., Ackermann, M., Li, H., Knowles Jr, D.P., Lewis, G.S., Brayton, K.A. 2007. Comparison of ovine herpesvirus 2 genomes isolated from domestic sheep (Ovis aries) and a clinically affected cow (Bos bovis). Journal of General Virology. 88(1):40-45.A NOVEL 78-KDA FATTY ACYL-COA SYNTHETASE (ACS1) OF BABESIA BOVIS STIMULATES MEMORY CD4+ T LYMPHOCYTE RESPONSES IN B. BOVIS-IMMUNE CATTLE

- (Peer Reviewed Journal)Norimine, J., Ruef, B.J., Palmer, G.H., Knowles Jr, D.P., Herndon, D.R., Rice-Ficht, A.C., Brown, W.C. 2006. A novel 78-kDa fatty acyl-CoA synthetase (ACS1) of Babesia bovis stimulates memory CD4+ T lymphocyte responses in B. bovis-immune cattle. Molecular and Biochemical Parasitology. 147(1):20-29COMPLETE GENOME SEQUENCING OF ANAPLASMA MARGINALE REVEALS THAT THE SURFACE IS SKEWED TO TWO SUPERFAMILIES OF OUTER MEMBRANE PROTEINS

- (Peer Reviewed Journal)Brayton, K.A., Kappmeyer, L.S., Herndon, D.R., Dark, M.J., Tibbals, D.L., Palmer, G.H., Mcguire, T.C., Knowles Jr, D.P. 2005. Complete genome sequencing of anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins. Proceedings of the National Academy of Sciences. 102(3):844-849.


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