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 U.S. Meat Animal Research Center: Clay Center, NE
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ARS Home Plains Area Clay Center, Nebraska U.S. Meat Animal Research Center BCHF





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BCHF mainheadline bar **Bovine Congestive Heart Failure (BCHF) in Feedlot Cattle** Bovine congestive heart failure (BCHF) is increasingly recognized as an emerging condition of cattle in the Western Great Plains of the United States and Canada.  BCHF is an untreatable, fatal condition involving pulmonary hypertension that culminates in right ventricular failure.  BCHF outbreaks are occurring in operations feeding well-managed, high genetic merit cattle. For some producers, it is the single most costly health-related problem with losses exceeding $250,000 annually in individual operations, even surpassing those from bovine respiratory disease. Consequently, reducing the impact of BCHF is a high priority for the cattle industry. /ARSUserFiles/30400500/BCHF_photos/Figure1_CasesAtEveryStage250k.jpg **BCHF clinical cases at different stages of fattening.** Three types of animals identified by feedlot pen riders as end-stage heart failure candidates. Clinical cases were born and raised at 1,000 to 1,200 m prior to feedlot arrival. Their respective heart gross morphologies with enlarged right ventricles and pulmonary arteries are shown below each case. The control heart is from an Angus heifer fattened at 550 m (Heaton et al., F1000Research 2019).  /ARSUserFiles/30400500/BCHF_photos/BCHF_CaseDefinitin250k.jpg Heaton et al. 2022, F1000Research 2022, **11**:385 /ARSUserFiles/30400500/BCHF_photos/Cardiomegaly6AngusHeifers250k.jpg Heaton MP, 2017, unpublished. **Genetic risk factors identified for BCHF in feedlot cattle** **Scientific publication (updated 2024, April 2022,)** Heaton MP, Harhay GP, Bassett AS, Clark HJ, Carlson JM, Jobman EE, Sadd HR, Pelster MC, Workman AM, Kuehn LA, Kalbfleisch TS, Piscatelli H, Carrie M, Krafsur GM, Grotelueschen DM, Vander Ley BL.****Association of ARRDC3 and NFIA variants with bovine congestive heart failure in feedlot cattle** [version 1; peer-reviewed]. F1000Research 2022, **11**:385 **Additional notes for genotyping companies (March 2024)** **ARS115 Public data release (May 2022)** **Preliminary release of JMJD1C variants associated with bovine congestive heart failure in feedlot cattle** **Updated USMARC-UNL Factsheet on genetic risk factor testing (April 2022)** **Factsheet:** Genetic risk factor testing for bovine congestive heart failure in feedlot cattle International Plant and Animal Genome meeting XXVIII January 13, 2020, San Diego, CA, USA **Poster PE0326:** Association of*ARRDC3*and*NFIA*Genes with Bovine Congestive Heart Failure **Slide presentation:** Genetic Association with Bovine Congestive Heart Failure in Feedlot Cattle  January 13, 2020, press release describing new genetic testing: New genetic test for bovine congestive heart failure may help breeding and management decisions September, 2018, workshop report: Bovine pulmonary hypertension and congestive heart failure collaborators' Workshop, Clay Center Nebraska


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