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                    U.S. DEPARTMENT OF AGRICULTURE
 Infectious Bacterial Diseases Research: Ames, IA
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ARS Home Midwest Area Ames, Iowa National Animal Disease Center Infectious Bacterial Diseases Research People & Locations







Paola  Boggiatto
                        Infectious Bacterial Diseases Research

                        




                        
                        Veterinary Medical Officer
                        Phone: (515) 337-6527
                        
                        
                        Fax: (Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            ProjectsDevelopment of Improved Diagnostic and Control Strategies for Brucellosis in Livestock and Wildlife
                                                    In-House Appropriated
                                                                    (D)Accession Number: 441161TB Diagnostics in Vaccinated Cattle and Deer
                                                    Interagency Reimbursable Agreement
                                                                    (I)Accession Number: 442512Experimental Infections of Elk With SARS-CoV-2
                                                    Interagency Reimbursable Agreement
                                                                    (I)Accession Number: 442977SARS-CoV-2 White-tailed Deer Infection Dynamics and Antibody Persistence
                                                    Interagency Reimbursable Agreement
                                                                    (I)Accession Number: 443025Development and Validation of TB Diagnostics for Deer and Cattle that have been Vaccinated with BCG
                                                    Interagency Reimbursable Agreement
                                                                    (I)Accession Number: 438758**Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)An injectable subunit vaccine containing Elongation Factor Tu and Heat Shock Protein 70 protects North American bison from Mycoplasma bovis infection

- (Peer Reviewed Journal)Persistence of viral RNA in North American elk experimentally infected with an ancestral variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
                                                        

- (Peer Reviewed Journal)Boggiatto, P.M., Devries, A.C., Cassmann, E.D., Seger, H., Olsen, S.C., Palmer, M.V. 2024. Persistence of viral RNA in North American elk experimentally infected with an ancestral variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Scientific Reports. https://doi.org/10.1038/s41598-024-61414-7.Fecal and vaginal microbiota of vaccinated and non-vaccinated pregnant elk challenged with Brucella abortus
                                                        

- (Peer Reviewed Journal)Tibbs-Cortes, B.W., Rahic-Seggerman, F.M., Schmitz-Esser, S., Boggiatto, P.M., Olsen, S.C., Putz, E.J. 2024. Fecal and vaginal microbiota of vaccinated and non-vaccinated pregnant elk challenged with Brucella abortus. Frontiers in Veterinary Science. 11. https://doi.org/10.3389/fvets.2024.1334858.Evaluation of the PrimeFlow RNA assay as a method of detection of SARS-CoV-2 single and dual Infections
                                                        

- (Peer Reviewed Journal)Falkenberg, S.M., Devries, A.C., Boggiatto, P.M. 2023. Evaluation of the PrimeFlow RNA assay as a method of detection of SARS-CoV-2 single and dual Infections. Proceedings of the National Academy of Sciences (PNAS). https://doi.org/10.1007/s10616-023-00608-9.Genomic regions associated with pseudorabies virus infection status in naturally infected feral swine (Sus scrofa)
                                                        

- (Peer Reviewed Journal)Bowden, C.F., Kiser, J.N., Miller, R.S., Devries, A.C., Boggiatto, P.M., Giglio, R.M., Brown, V.R., Garrick, D., Neibergs, H.L., Piaggio, A.J., Speidel, S.E., Smyser, T.J. 2023. Genomic regions associated with pseudorabies virus infection status in naturally infected feral swine (Sus scrofa). Frontiers in Genetics. https://doi.org/10.3389/fgene.2023.1292671.Effect of Selection Genotype on Immune Response to Brucella abortus RB51 in Holstein Cattle
                                                        

- (Peer Reviewed Journal)Sarlo Davila, K.M., Boggiatto, P.M., Olsen, S.C., Lippolis, J.D., Crooker, B., Putz, E.J. 2023. Effect of Selection Genotype on Immune Response to Brucella abortus RB51 in Holstein Cattle. Animal Genetics. 55(1):47-54. https://doi.org/10.1111/age.13372.Vaccination of white-tailed deer with Mycobacterium bovis bacillus Calmette-Guérin (BCG): Effect of Mycobacterium avium ssp. paratuberculosis infection
                                                        

- (Peer Reviewed Journal)Palmer, M.V., Kanipe, C.R., Lehman, K.A., Thacker, T.C., Putz, E.J., Boggiatto, P.M. 2023. Vaccination of white-tailed deer with Mycobacterium bovis bacillus Calmette-Guérin (BCG): Effect of Mycobacterium avium ssp. paratuberculosis infection. Microorganisms. https://doi.org/10.3390/microorganisms11102488.Wildlife immune responses to Mycobacterium bovis and to Bacille of Calmette-Guerin
                                                        

- (Review Article)Boggiatto, P.M., Kanipe, C.R., Putz, E.J., Olsen, S.C., Palmer, M.V. 2023. Wildlife immune responses to Mycobacterium bovis and to Bacille of Calmette-Guerin. Journal of Immunology. https://doi.org/10.4049/jimmunol.2300323.Response to bovine viral diarrhea virus in heifers vaccinated with a combination of multivalent modified live and inactivated viral vaccines
                                                        

- (Peer Reviewed Journal)Falkenberg, S.M., Dassanayake, R.P., Crawford, L., Sarlo Davila, K.M., Boggiatto, P.M. 2023. Response to bovine viral diarrhea virus in heifers vaccinated with a combination of multivalent modified live and inactivated viral vaccines. Viruses. 15(3). Article 703.. https://doi.org/10.3390/v15030703.Effects of concurrent administration of modified live viral vaccines with RB51 on immune responses to RB51
                                                        

- (Peer Reviewed Journal)Crawford, L., Falkenberg, S., Putz, E.J., Olsen, S.C., Boggiatto, P.M. 2023. Effects of concurrent administration of modified live viral vaccines with RB51 on immune responses to RB51. Frontiers in Veterinary Science. 10. eArticle 1105485. https://doi.org/10.3389/fvets.2023.1105485.Histopathologic differences in granulomas of BCG vaccinated and non-vaccinated cattle with bovine tuberculosis
                                                        

- (Peer Reviewed Journal)Kanipe, C.R., Boggiatto, P.M., Putz, E.J., Palmer, M.V. 2022. Histopathologic differences in granulomas of BCG vaccinated and non-vaccinated cattle with bovine tuberculosis. Frontiers in Microbiology. 13, Article 1048648. https://doi.org/10.3389/fmicb.2022.1048648.Pulmonary hamartoma in an elk calf (Cervus elaphus canadensis)
                                                        

- (Peer Reviewed Journal)Boggiatto, P.M., Olsen, S.C., Palmer, M.V. 2022. Pulmonary hamartoma in an elk calf (Cervus elaphus canadensis). Journal of Veterinary Diagnostic Investigation. 35(2). https://doi.org/10.1177/10406387221141091.SARS-CoV-2: Experimental studies on deer-to-deer transmission
                                                        

- (Abstract Only)Palmer, M.V., Martins, M., Falkenberg, S.M., Devries, A.C., Caserta, L., Mitchell, P.K., Wagner, B., Cassmann, E.D., Lager, K.M., Diel, D.G., Boggiatto, P.M., Kanipe, C.R., Fernandes, M. 2022. SARS-CoV-2: Experimental studies on deer-to-deer transmission. United States Animal Health Association Proceedings. [Abstract}. https://doi.org/10.1371/journal.ppat.1010197.Characterization of the duration of immunity of Brucella abortus strain RB51 vaccination in cattle after experimental challenge
                                                        

- (Peer Reviewed Journal)Olsen, S.C., Boggiatto, P.M. 2022. Characterization of the duration of immunity of Brucella abortus strain RB51 vaccination in cattle after experimental challenge. Preventive Veterinary Medicine. 206. Article 105705. https://doi.org/10.1016/j.prevetmed.2022.105705.From Deer-to-Deer: SARS-CoV-2 is efficiently transmitted and presents broad tissue tropism and replication sites in white-tailed deer
                                                        

- (Peer Reviewed Journal)Martins, M., Boggiatto, P.M., Buckley, A., Cassmann, E.D., Falkenberg, S.M., Caserta, L.C., Fernandes, M.H., Kanipe, C.R., Lager, K.M., Palmer, M.V., Diel, D.G. 2022. From Deer-to-Deer: SARS-CoV-2 is efficiently transmitted and presents broad tissue tropism and replication sites in highly susceptible white-tailed deer. PLoS Pathogens. 18(3). Article e1010197. https://doi.org/10.1371/journal.ppat.1010197.Bovine tuberculosis: a disease at the interface of cattle, wildlife and humans
                                                        

- (Book / Chapter)Palmer, M.V., Boggiatto, P.M., Kanipe, C., Lombard, J. 2023. Bovine tuberculosis: a disease at the interface of cattle, wildlife and humans. Book Chapter. 11(p 829-846). https://doi.org/10.1007/978-3-031-15955-8.The bovine tuberculoid granuloma
                                                        

- (Review Article)Palmer, M.V., Kanipe, C.R., Boggiatto, P.M. 2022. The bovine tuberculoid granuloma. Pathogens. 11(1).  Article 61. https://doi.org/10.3390/pathogens11010061.Research on a TB vaccine for use in free-ranging white-tailed deer

- (Abstract Only)Immune responses and efficacy of Brucella abortus strain RB51 in bison after delivery in a dry dart formulation or by parenteral inoculation
                                                        

- (Peer Reviewed Journal)Olsen, S.C., Boggiatto, P.M., Nol, P., Mccollum, M., Rhyan, J. 2021. Immune responses and efficacy of Brucella abortus strain RB51 in bison after delivery in a dry dart formulation or by parenteral inoculation. Frontiers in Veterinary Science. 8. Article 706160. https://doi.org/10.3389/fvets.2021.706160.Immune responses and efficacy of a Brucella abortus dry dart in bison
                                                        

- (Peer Reviewed Journal)Olsen, S.C., Boggiatto, P.M., Nol, P., Mccollum, M., Rhyan, J. 2021. Immune responses and efficacy of a Brucella abortus dry dart in bison. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2021.706160.Enhanced detection of Mycobacterium bovis-specific T cells in experimentally-infected cattle
                                                        

- (Peer Reviewed Journal)Boggiatto, P.M., Kanipe, C.R., Palmer, M.V. 2021. Enhanced detection of Mycobacterium bovis-specific T cells in experimentally-infected cattle. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2021.676710.Mucosal IFN-¿ production and potential role in protection in Escherichia coli O157:H7 vaccinated and challenged cattle
                                                        

- (Peer Reviewed Journal)Schaut, R.G., Palmer, M.V., Boggiatto, P.M., Kudva, I.T., Loving, C.L., Sharma, V.K. 2021. Mucosal IFN-¿ production and potential role in protection in Escherichia coli O157:H7 vaccinated and challenged cattle. Infection and Immunity. 11. Article 9769. https://doi.org/10.1038/s41598-021-89113-7.Heterogeneity of pulmonary granulomas in cattle experimentally infected with Mycobacterium bovis
                                                        

- (Peer Reviewed Journal)Palmer, M.V., Thacker, T.C., Kanipe, C.R., Boggiatto, P.M. 2021. Heterogeneity of pulmonary granulomas in cattle experimentally infected with Mycobacterium bovis. Frontiers in Veterinary Science. 8. https://doi.org/10.3389/fvets.2021.671460.A pseudomolecule assembly of the Rocky Mountain elk genome
                                                        

- (Peer Reviewed Journal)Masonbrink, R.E., Alt, D.P., Bayles, D.O., Boggiatto, P.M., Edwards, H., Tatum, F.M., Williams, J.E., Wilson-Welder, J.H., Wood, M., Zimin, A., Severin, A., Olsen, S.C. 2021. A pseudomolecule assembly of the Rocky Mountain elk genome. PLoS ONE. 16(4). https://doi.org/10.1371/journal.pone.0249899.Quantification of Brucella abortus population structure in a natural host
                                                        

- (Peer Reviewed Journal)Fiebig, A., Vrentas, C.E., Le,T, Huebner, M., Boggiatto, P.M., Olsen, S.C., Crosson, S. 2021. Quantification of Brucella abortus population structure in a natural host. Proceedings of the National Academy of Sciences(PNAS). 118. https://doi.org/10.1073/pnas.2023500118.Loci Associated With Antibody Response in Feral Swine (Sus scrofa)Infected With Brucella suis
                                                        

- (Peer Reviewed Journal)Pierce,  .F., Brown, V.R., Olsen, S.C., Boggiatto, P.M., Pedersen, K., Miller, R.S. Speidel, S.E., Smyser, T.J. 2020. Loci associated with antibody response in feral swine (Sus scrofa)infected with Brucella suis. Frontiers in Veterinary Science. 7. https://doi.org/10.3389/fvets.2020.554674.Severity of bovine tuberculosis is associated with innate immune-biased transcriptional signatures of whole blood in early weeks after experimental Mycobacterium bovis infection
                                                        

- (Peer Reviewed Journal)Wiarda, J.E., Boggiatto, P.M., Bayles, D.O., Waters, R.W., Thacker, T.C., Palmer, M.V. 2020. Severity of bovine tuberculosis is associated with innate immune-biased transcriptional signatures of whole blood in early weeks after experimental Mycobacterium bovis infection. PLoS ONE. 15(11). https://doi.org/10.1371/journal.pone.0239938.Influence of species of negative control sera on results of a brucellosis fluorescence polarization assay
                                                        

- (Peer Reviewed Journal)Olsen, S.C., Crawford, L., Fuentes, A., Kostovic, M., Boggiatto, P.M. 2020. Influence of species of negative control sera on results of a brucellosis fluorescence polarization assay . Journal of Veterinary Diagnostic Investigation. 33:67-72. https://doi.org/10.1177/1040638720970888.Enhancing the detection of Brucella-specific CD4+ T cell responses in cattle via in vitro antigenic expansion and restimulation
                                                        

- (Peer Reviewed Journal)Boggiatto, P.M., Schaut, R.G., Olsen, S.C. 2020. Enhancing the detection of Brucella-specific CD4+ T cell responses in cattle via in vitro antigenic expansion and restimulation. Frontiers in Immunology. 11:1944. https://doi.org/10.3389/fimmu.2020.01944.Case report: fading elk syndrome in a herd of captive elk (Cervus elaphus) in the North American midwest
                                                        

- (Peer Reviewed Journal)Boggiatto, P.M., Crawford, L.S., Kanipe, C., Palmer, M.V., Olsen, S.C. 2020. Case report: fading elk syndrome in a herd of captive elk (Cervus elaphus) in the North American midwest. Frontiers in Veterinary Science. 7:497. https://doi.org/10.3389/fvets.2020.00497.Case report: fading elk syndrome in a herd of captive elk (Cervus elaphus) in the North American midwest
                                                        

- (Peer Reviewed Journal)Boggiatto, P.M., Crawford, L.S., Kanipe, C., Palmer, M.V., Olsen, S.C. 2020. Case report: fading elk syndrome in a herd of captive elk (Cervus elaphus) in the North American midwest. Meeting Abstract. 7. https://doi.org/10.3389/fvets.2020.00497.Immune responses and clinical effects of experimental challenge of elk with Brucella abortus strain 2308
                                                        

- (Peer Reviewed Journal)Olsen, S.C., Boggiatto, P.M., Kanipe, C. 2020. Immune responses and clinical effects of experimental challenge of elk with Brucella abortus strain 2308. Veterinary Immunology and Immunopathology. 227. https://doi.org/10.1016/j.vetimm.2020.110086.Bovine immune response to leptospiral antigen in different novel adjuvants and vaccine delivery platforms
                                                        

- (Peer Reviewed Journal)Wilson-Welder, J.H., Boggiatto, P.M., Nally, J.E., Wafa, E.I., Alt, D.P., Hornsby, R.L., Frank, A.T., Jones, D.E., Olsen, S.C., Bowden, N.B., Salem, A.K. 2020. Bovine immune response to leptospiral antigen in different novel adjuvants and vaccine delivery platforms. Vaccine. 38(18):3464-3473. https://doi.org/10.1016/j.vaccine.2020.02.086.Tulathromycin treatment does not affect bacterial dissemination or clearance of Brucella melitensis 16M following experimental infection of goats
                                                        

- (Peer Reviewed Journal)Boggiatto, P.M., Olsen, S.C. 2019. Tulathromycin treatment does not affect bacterial dissemination or clearance of Brucella melitensis 16M following experimental infection of goats. PLoS One. 14(12):e0226242. https://doi.org/10.1371/journal.pone.0226242.Characterization of the NLRP1 inflammasome response in bovine species
                                                        

- (Peer Reviewed Journal)Vrentas, C.E., Boggiatto, P.M., Olsen, S.C., Leppla, S.H., Moayeri, M. 2020. Characterization of the NLRP1 inflammasome response in bovine species. Innate Immunity. 26(4):301-311. https://doi.org/10.1177/1753425919886649.Sustained antigen release, polyanhydride-based vaccine platform for immunixation against bovine brucellosis
                                                        

- (Peer Reviewed Journal)Boggiatto, P.M., Schaut, R.G., Kanipe, C., Kelly, S.M., Narasimhan, B., Jones, D.E., Olsen, S.C. 2019. Sustained antigen release, polyanhydride-based vaccine platform for immunixation against bovine brucellosis. Heliyon. 5(8). https://doi.org/10.1016/j.heliyon.2019.e02370.Cellular and mucosal immune responses following vaccination with inactivated mutant of Escherichia coli O157:H7
                                                        

- (Peer Reviewed Journal)Schaut, R.G., Boggiatto, P.M., Loving, C.L., Sharma, V.K. 2019. Cellular and mucosal immune responses following vaccination with inactivated mutant of Escherichia coli O157:H7. Scientific Reports. 9:6401. https://doi.org/10.1038/s41598-019-42861-z.Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene expression in brucellosis
                                                        

- (Peer Reviewed Journal)Boggiatto, P.M., Vrentas, C.E., Fitzsimmons, D.J., Bayles, D.O., Alt, D.P., Olsen, S.C. 2018. Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene expression in brucellosis. BioMed Central (BMC) Molecular Biology. 19:10. https://doi.org/10.1186/s12867-018-0111-x.Inflammasomes in livestock and wildlife: Insights into the intersection of pathogens and natural host species
                                                        

- (Review Article)Vrentas, C.E., Schaut, R.G., Boggiatto, P.M., Olsen, S.C., Sutterwala, F.G., Moayeri, M. 2018. Inflammasomes in livestock and wildlife: Insights into the intersection of pathogens and natural host species. Veterinary Immunology and Immunopathology. 201:49-56. https://doi.org/10.1016/j.vetimm.2018.05.008.Collection and processing of lymph nodes from large animals for RNA analysis:  preparing for lymph node transcriptomic studies of large animal species
                                                        

- (Peer Reviewed Journal)Vrentas, C.E., Boggiatto, P.M., Schaut, R.G., Olsen, S.C. 2018. Collection and processing of lymph nodes from large animals for RNA analysis:  preparing for lymph node transcriptomic studies of large animal species. Journal of Visualized Experiments. 135:e57195. doi:10.3791/57195.Biosafety concerns related to Brucella and its potential use as a bioweapon
                                                        

- (Peer Reviewed Journal)Olsen, S.C., Boggiatto, P.M., White, D.M., McNunn, T.B. 2018. Biosafety concerns related to Brucella and its potential use as a bioweapon. Applied Biosafety. 23(2)77-90. https://doi.org/10.1177/1535676018771983.Inactivation of virulent Brucella species in culture and animal samples
                                                        

- (Peer Reviewed Journal)Olsen, S.C., Boggiatto, P.M., Vrentas, C.E. 2017. Inactivation of virulent Brucella species in culture and animal samples. Applied Biosafety. 22(4):145-151. https://doi.org/10.1177/1535676017734202.
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