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                    U.S. DEPARTMENT OF AGRICULTURE
 Ruminant Diseases and Immunology Research: Ames, IA
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ARS Home Midwest Area Ames, Iowa National Animal Disease Center Ruminant Diseases and Immunology Research People & Locations







Randy E Sacco
                        Ruminant Diseases and Immunology Research

                        




                        
                        Microbiologist
                        Phone: (515) 337-7354
                        
                        
                        Fax: (515) 337-7149(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            ProjectsContinued Development of an Immunological Toolkit and Profile for Bottlenose Dolphins
                                                    Cooperative Agreement
                                                                    (A)Accession Number: 444432Intervention Strategies to Prevent and Control Viral Respiratory Pathogens of Ruminants
                                                    In-House Appropriated
                                                                    (D)Accession Number: 441143Host-pathogen Interactions and Control Strategies for Bacterial Respiratory Pathogens in Cattle
                                                    In-House Appropriated
                                                                    (D)Accession Number: 441196Continued Development of an Immunological Toolkit and Profile for Bottlenose Dolphins
                                                    Reimbursable Cooperative Agreement
                                                                    (R)Accession Number: 445573Development of a Mucosal, Polyanhydride-based Nanoparticle Vaccine for Use Against Respiratory Syncytial Virus Infection in the Neonate
                                                    Reimbursable Cooperative Agreement
                                                                    (R)Accession Number: 437400Host-pathogen Interactions and Control Strategies for Bacterial Respiratory Pathogens in Cattle
                                                    Non-Assistance Cooperative Agreement
                                                                    (S)Accession Number: 442729**Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)An update on the development of a bottlenose dolphin, Tursiops truncatus, immune reagent toolkit
                                                        

- (Peer Reviewed Journal)Sacco, R.E., Jensen, E.D., Sullivan, Y., Labresh, J., Davis, W.C. 2024. An update on the development of a bottlenose dolphin, Tursiops truncatus, immune reagent toolkit. Veterinary Immunology and Immunopathology. Article 110769. https://doi.org/10.1016/j.vetimm.2024.110769.Serum IgG immunoglobulin levels correlate with clearance of Mycoplasma bovis in naturally infected North American bison (Bison bison)

- (Peer Reviewed Journal)Immunization with a mucosal, post-fusion F/G protein-based polyanhydride nanovaccine protects neonatal calves against BRSV infection
                                                        

- (Peer Reviewed Journal)Maina, T.W., Grego, E.A., Broderick, S., Sacco, R.E., Narasimhan, B., Mcgill, J.L. 2023. Immunization with a mucosal, post-fusion F/G protein-based polyanhydride nanovaccine protects neonatal calves against BRSV infection. Frontiers in Immunology. 14. Article 1186184. https://doi.org/10.3389/fimmu.2023.1186184.Identification of a DRB3*011:01-restricted CD4+ T cell response against bovine respiratory syncytial virus fusion protein
                                                        

- (Peer Reviewed Journal)Kaplan, B.S., Hofstetter, A.R., McGill, J.L., Lippolis, J.D., Norimine, J., Dassanayake, R.P., Sacco, R.E. 2023. Identification of a DRB3*011:01-restricted CD4+ T cell response against bovine respiratory syncytial virus fusion protein. Frontiers in Immunology. 14. Article 1040075.. https://doi.org/10.3389/fimmu.2023.1040075.An intranasal recombinant NDV-RSV F opt vaccine is safe and reduces lesion severity in a colostrum-deprived calf model of BRSV infection
                                                        

- (Peer Reviewed Journal)Sacco, R.E., Mena, I., Palmer, M.V., Durbin, R.K., Garcia-Sastre, A., Durbin, J.E. 2022. An intranasal recombinant NDV-RSV F opt vaccine is safe and reduces lesion severity in a colostrum-deprived calf model of BRSV infection. Scientific Reports. 12(1). Article 22552. https://doi.org/10.1038/s41598-022-26938-w.Comparative analysis of the specificity of monoclonal antibodies developed against the bottlenose dolphin, Tursiops truncatus, TNF-a, IL1-ß, IL-6, IL-8, IL-10 with monoclonal antibodies made against ovine IFN-y bovine IL-17A
                                                        

- (Peer Reviewed Journal)Sacco, R.E., Elnaggar, M.M., Abdellrazeq, G.S., Fry, L.M., Hulubei, V., Davis, W.C., Harsla, T., Mucci, M.L. 2022. Comparative analysis of the specificity of monoclonal antibodies developed against the bottlenose dolphin, Tursiops truncatus, TNF-a, IL1-ß, IL-6, IL-8, IL-10 with monoclonal antibodies made against ovine IFN-y bovine IL-17A. Veterinary Immunology and Immunopathology. 250. Article 110456. https://doi.org/10.1016/j.vetimm.2022.110456.Ex vivo activated CD4+ T cells from young calves exhibit Th2-biased effector function with distinct metabolic reprogramming compared to adult cows
                                                        

- (Peer Reviewed Journal)Eder, J.M., Sacco, R.E. 2022. Ex vivo activated CD4+ T cells from young calves exhibit Th2-biased effector function with distinct metabolic reprogramming compared to adult cows. Veterinary Immunology and Immunopathology. 248. Article 110418. https://doi.org/10.1016/j.vetimm.2022.110418.The immunology of bovine respiratory disease: recent advancements
                                                        

- (Peer Reviewed Journal)McGill, J.L., Sacco, R.E. 2020. The immunology of bovine respiratory disease: recent advancements. Veterinary Clinics of North America. 36(2):333-348. https://doi.org/10.1016/j.cvfa.2020.03.002.Lactation stage impacts the glycolytic function of bovine CD4+ T cells during ex vivo activation
                                                        

- (Peer Reviewed Journal)Eder, J.M., Gorden, P.J., Lippolis, J.D., Reinhardt, T.A., Sacco, R.E. 2020. Lactation stage impacts the glycolytic function of bovine CD4+ T cells during ex vivo activation. Nature Scientific Reports. 10(4045). https://doi.org/10.1038/s41598-020-60691-2.Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves
                                                        

- (Peer Reviewed Journal)McGill, J.L., Kelly, S.M., Guerra-Maupome, M., Winkley, E., Henningson, J., Narasimhan, B., Sacco, R.E. 2019. Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves. Scientific Reports. 9(15157). https://doi.org/10.1038/s41598-019-51684-x.Oxidative stress pathway gene transcription after bovine respiratory syncytial virus infection in vitro and in vivo
                                                        

- (Peer Reviewed Journal)Hofstetter, A.R., Sacco, R.E. 2019. Oxidative stress pathway gene transcription after bovine respiratory syncytial virus infection in vitro and in vivo. Veterinary Immunology and Immunopathology. 219(2020):109956. https://doi.org/10.1016/j.vetimm.2019.109956.Differential phenotype of immune cells in blood and milk following pegylated granulocyte colony stimulating factor (PEG-gCSF) therapy during a chronic Staphylococcus aureus infection in lactating Holsteins
                                                        

- (Peer Reviewed Journal)Powell, E.J., Eder, J.M., Reinhardt, T.A., Sacco, R.E., Casas, E., Lippolis, J.D. 2019. Differential phenotype of immune cells in blood and milk following pegylated granulocyte colony stimulating factor (PEG-gCSF) therapy during a chronic Staphylococcus aureus infection in lactating Holsteins. Journal of Dairy Science. 102(10):9268-9284. https://doi.org/10.3168/jds.2019-16448.Bovine NK-lysin-derived peptide NK2A demonstrates immunomodulatory activity on cattle leukocytes

- (Abstract Only)Bovine respiratory syncytial virus infection

- (Book / Chapter)McGill, J.L., Sacco, R.E. 2019. Chapter 52: bovine respiratory syncytial virus infection. In: Coetzer, J.A.W., Thomson, G.R., Maclachaln, N.J., Penrith, M.L., editors. Infectious Diseases of Livestock. Africa. Anipedia. Part 2.Utility of the neonatal calf model for testing vaccines and intervention strategies for use against human RSV infection
                                                        

- (Peer Reviewed Journal)Guerra-Maupome, M., Palmer, M.V., McGill, J.L., Sacco, R.E. 2019. Utility of the neonatal calf model for testing vaccines and intervention strategies for use against human RSV infection. Vaccines. 7(1):7. https://doi.org/10.3390/vaccines7010007.Relative virulence in bison and cattle of bison-associated genotypes of mycoplasma bovis
                                                        

- (Peer Reviewed Journal)Register, K.B., Olsen, S.C., Sacco, R.E., Ridpath, J., Falkenberg, S., Briggs, R., Kanipe, C., Madison, R. 2018. Relative virulence in bison and cattle of bison-associated genotypes of Mycoplasma bovis. Veterinary Microbiology. 222:55-63. https://doi.org/10.1016/j.vetmic.2018.06.020.Immunomediator expression profiling in two beluga whale (delphinapterus leucas) clinical cases

- (Abstract Only)Identification of a DRB3*1101-restricted CD4 T cell response against bovine respiratory syncytial virus

- (Abstract Only)Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf
                                                        

- (Peer Reviewed Journal)McGill, J.L., Kelly, S.M., Kumar, P., Speckhart, S., Haughney, S.L., Henningson, J., Narasimhan, B., Sacco, R.E. 2018. Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf. Scientific Reports. 8:3021. https://doi.org/10.1038/s41598-018-21292-2.Development and testing of species-specific ELISA assays to measure IFN-gamma and TNF-alpha in bottlenose dolphins (Tursiops truncatus)
                                                        

- (Peer Reviewed Journal)Eberle, K.C., Venn-Watson, S.K., Jensen, E.D., Labresh, J., Sullivan, Y., Kakach, L., Sacco, R.E. 2018. Development and testing of species-specific ELISA assays to measure IFN-gamma and TNF-alpha in bottlenose dolphins (Tursiops truncatus). PLoS One. 13(1):e0190786. https://doi.org/10.1371/journal.pone.0190786.Longitudinal monitoring of bottlenose dolphins leukocyte cytokine mRNA responsiveness by qPCR

- (Abstract Only)Efficacy of a mucosal, polyanhydride nanovaccine for use against respiratory syncytial virus infection in the neonatal calf
                                                        

- (Peer Reviewed Journal)McGill, J.L., Kelly, S.M., Kumar, P., Speckhart, S., Haughney, S.L., Henningson, J., Narasimhan, B., Sacco, R.E. 2018. Efficacy of mucosal, polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf. Nature Scientific Reports. 8(1):3021. https://doi.org/10.1038/s41598-018-21292-2.Genomic and transcriptomic analysis of Escherichia coli strains associated with persistent and transient bovine mastitis and the role of colanic acid
                                                        

- (Peer Reviewed Journal)Lippolis, J.D., Holman, D.B., Brunelle, B.W., Thacker, T.C., Bearson, B.L., Reinhardt, T.A., Sacco, R.E., Casey, T. 2017. Genomic and transcriptomic analysis of Escherichia coli strains associated with persistent and transient bovine mastitis and the role of colanic acid. Infection and Immunity. 86(1):e00566-17. https://doi.org/10.1128/IAI.00566-17.Monitoring bottlenose dolphin leukocyte cytokine mRNA responsiveness by qPCR
                                                        

- (Peer Reviewed Journal)Hofstetter, A.R., Eberle, K.C., Venn-Watson, S.K., Jensen, E.D., Porter, T.J., Waters, T.E., Sacco, R.E. 2017. Monitoring bottlenose dolphin leukocyte cytokine mRNA responsiveness by qPCR. PLoS One. 12(12):e0189437. https://doi.org/10.1371/journal.pone.0189437.Identification of monoclonal antibodies cross-reactive with bottlenose dolphin orthologues of the major histocompatibility complex and leukocyte differentiation molecules
                                                        

- (Peer Reviewed Journal)Elnaggar, M.M., Abdellrazeq, G.S., Venn-Watson, S.K., Jensen, E.D., Mack, V., Fry, L.M., Sacco, R.E., Davis, W.C. 2017. Identification of monoclonal antibodies cross-reactive with bottlenose dolphin orthologues of the major histocompatibility complex and leukocyte differentiation molecules. Developmental and Comparative Immunology. 192:54-59. https://doi.org/10.1016/j.vetimm.2017.09.007.Longitudinal monitoring of bottlenose dolphin leukocyte cytokine mRNA responsiveness by qPCR

- (Abstract Only)Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni
                                                        

- (Peer Reviewed Journal)Dassanayake, R.P., Falkenberg, S.M., Briggs, R.E., Tatum, F.M., Sacco, R.E. 2017. Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni. PLoS One. 12(8):1-14. doi. 10.1371/journal.pone.0183610.Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni

- (Abstract Only)Genome sequences of Escherichia coli strains that cause persistent and transient mastitis
                                                        

- (Peer Reviewed Journal)Thacker, T.C., Lippolis, J.D., Brunelle, B.W., Casey, T., Reinhardt, T.A., Sacco, R.E., Holman, D.B. 2017. Genome sequences of Escherichia coli strains that cause persistent and transient mastitis. Genome Announcements. 5(34):e00775-17. https://doi.org/10.1128/genomeA.00775-17.Development of specific cytokine and Chemokine ELISAs for Bottlenose Dolphins

- (Abstract Only)Vitamin D status of dairy cattle: Outcomes of current practices in the dairy industry
                                                        

- (Peer Reviewed Journal)Nelson, C.D., Lippolis, J.D., Reinhardt, T.A., Sacco, R.E., Powell, T.L., Drewnoski, M.E., O'Neill, M., Beitz, D.C., Weiss, W.P. 2016. Vitamin D status of dairy cattle: Outcomes of current practices in the dairy industry. Journal of Dairy Science. 99:10150-10160.Bovine viral diarrhea virus type 2 impairs macrophage responsiveness to toll-like receptor ligation with the exception of toll-like receptor 7
                                                        

- (Peer Reviewed Journal)Schaut, R.G., Ridpath, J.F., Sacco, R.E. 2016. Bovine viral diarrhea virus type 2 impairs macrophage responsiveness to toll-like receptor ligation with the exception of toll-like receptor 7. PLoS One. 11(7):e0159491. doi: 10.1371/journal.pone.0159491.Differential gene expression of three mastitis-causing Escherichia coli strains grown under planktonic, swimming, and swarming culture conditions
                                                        

- (Peer Reviewed Journal)Lippolis, J.D., Brunelle, B.W., Reinhardt, T.A., Sacco, R.E., Thacker, T.C., Looft, T.P., Casey, T. 2016. Differential gene expression of three mastitis-causing Escherichia coli strains grown under planktonic, swimming, and swarming culture conditions. mSystems. 1(4):e00064-16.Bovine gamma delta T cells contribute to exacerbated IL-17 production in response to co-infection with Bovine RSV and Mannheimia haemolytica

- (Peer Reviewed Journal)McGill, J.L., Rusk, R.A., Guerra-Maupome, M., Briggs, R.E., Sacco, R.E. 2016. Bovine gamma delta T cells contribute to exacerbated IL-17 production in response to co-infection with Bovine RSV and Mannheimia haemolytica. PLoS One. 11(3):e0151083. doi: 10.1371/journal.pone.0151083.Gamma delta T cells and the immune response to respiratory syncytial virus infection
                                                        

- (Peer Reviewed Journal)McGill, J.L., Sacco, R.E. 2016. Gamma delta T cells and the immune response to respiratory syncytial virus infection. Veterinary Immunology and Immunopathology. doi: 10.1016/j.vetimm.2016.02.012.Parainfluenza virus 3 blocks antiviral mediators downstream of the interferon lambda receptor by modulating stat1 phosphorylation
                                                        

- (Peer Reviewed Journal)Eberle, K.C., McGill, J.L., Reinhardt, T.A., Sacco, R.E. 2016. Parainfluenza virus 3 blocks antiviral mediators downstream of the interferon lambda receptor by modulating stat1 phosphorylation. Journal of Virology. 90:2948-2958. doi:10.1128/JVI.02502-15.Novel Atlantic bottlenose dolphin parainfluenza virus TtPIV-1 clusters with bovine PIV-3 genotype B strains
                                                        

- (Peer Reviewed Journal)Eberle, K.C., Neill, J.D., Venn-Watson, S.K., McGill, J.L., Sacco, R.E. 2015. Novel Atlantic bottlenose dolphin parainfluenza virus TtPIV-1 clusters with bovine PIV-3 genotype B strains. Virus Genes. 51:198-208. doi: 10.1007/s11262-015-1224-7.Animal models of respiratory syncytial virus infection and disease
                                                        

- (Peer Reviewed Journal)Sacco, R.E., Durbin, R.K., Durbin, J.E. 2015. Animal models of respiratory syncytial virus infection and disease. Current Opinion in Virology. 13:117-122. doi: 10.1016/j.coviro.2015.06.003.Bovine viral diarrhea virus type 2 in vivo infection modulates TLR4 responsiveness in differentiated Myeloid cells which is associated with decreased MyD88 expression

- (Peer Reviewed Journal)Schaut, R.G., McGill, J.L., Neill, J.D., Ridpath, J.F., Sacco, R.E. 2015. Bovine viral diarrhea virus type 2 in vivo infection modulates TLR4 responsiveness in differentiated Myeloid cells which is associated with decreased MyD88 expression. Virus Research. 208:44-55. DOI: 10.1016/j.viruses.2015.05.017.Innate and adaptive immune responses to in utero infection with bovine viral diarrhea virus
                                                        

- (Peer Reviewed Journal)Hansen, T.R., Smirnova, N.P., Webb, B.T., Bielefeldt-Ohmann, H., Sacco, R.E., Van Campen, H. 2015. Innate and adaptive immune responses to in utero infection with bovine viral diarrhea virus. Animal Health Research Reviews. 16(1):15-26. DOI: 10.1017/S1466252315000122.Immune responses of bison and efficacy after booster vaccination with Brucella abortus strain RB51
                                                        

- (Peer Reviewed Journal)Olsen, S.C., McGill, J.L., Sacco, R.E., Hennager, S.G. 2015. Immune responses of bison and efficacy after booster vaccination with Brucella abortus strain RB51. Clinical and Vaccine Immunology. 22(4):440-447. doi: 10.1128/CVI.00746-14.MicroRNA expression profiling in tonsils of calves challenged with a laboratory strain or field isolates of Bovine Respiratory Syncytial Virus

- (Abstract Only)Proteomic analysis reveals protein expression differences in Escherichia coli strains associated with persistent versus transient mastitis
                                                        

- (Peer Reviewed Journal)Lippolis, J.D., Brunelle, B.W., Reinhardt, T.A., Sacco, R.E., Nonnecke, B.J., Dogan, B., Simpson, K., Schukken, Y. 2014. Proteomic analysis reveals protein expression differences in Escherichia coli strains associated with persistent versus transient mastitis. Journal of Proteomics. 108:373-381. DOI: 10.1016/j.jprpt.2014.06.008.Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves
                                                        

- (Peer Reviewed Journal)Nonnecke, B.J., McGill, J.L., Ridpath, J.F., Sacco, R.E., Lippolis, J.D., Reinhardt, T.A. 2014. Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves. Journal of Dairy Science. 97(9):5566-5579. DOI: 10.3168/jds.2014-8293.The role of gamma delta T cells in immunity to Mycobacterium bovis infection in cattle
                                                        

- (Review Article)McGill, J.L., Sacco, R.E., Baldwin, C.L., Telfer, J.C., Palmer, M.V., Waters, W.R. 2014. The role of gamma delta T cells in immunity to Mycobacterium bovis infection in cattle. Veterinary Immunology and Immunopathology. 159(3-4)133-143. doi.org/10.1016/j.vetimm.2014.02.010.Changes observed in the thymus and lymph nodes 14 days after exposure to BVDV field strains of enhanced or typical virulence in neonatal calves
                                                        

- (Peer Reviewed Journal)Falkenberg, S.M., Johnson, C., Bauermann, F.V., McGill, J.L., Palmer, M.V., Sacco, R.E., Ridpath, J.F. 2014. Changes observed in the thymus and lymph nodes 14 days after exposure to BVDV field strains of enhanced or typical virulence in neonatal calves. Veterinary Immunology and Immunopathology. 160(1-2):70-80. DOI: 10.1016/j.vetimm.2014.03.018.The Ca2+/H+ antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca2+ATPase (SPCA1)
                                                        

- (Peer Reviewed Journal)Reinhardt, T.A., Lippolis, J.D., Sacco, R.E. 2014. The Ca2+/H+ antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca2+ATPase (SPCA1). Biochemical and Biophysical Research Communications. 445(2):417-421.Induction of interferon-gamma and downstream pathways during establishment of fetal persistent infection with bovine viral diarrhea virus
                                                        

- (Peer Reviewed Journal)Smirnova, N.P., Webb, B.T., McGill, J.L., Schaut, R.G., Bielefeldt-Ohmann, H., Van Campen, H., Sacco, R.E., Hansen, T.R. 2014. Induction of interferon-gamma and downstream pathways during establishment of fetal persistent infection with bovine viral diarrhea virus. Virus Research. 183:95-106. DOI: 10.1016/j.virusres.2014.02.002.Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis
                                                        

- (Peer Reviewed Journal)McGill, J.L., Sacco, R.E., Baldwin, C.L., Telfer, J.C., Palmer, M.V., Waters, W.R. 2014. Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis. Journal of Immunology. 192(6):2756-2769. doi.org/10.4049/jimmunol.1302567.Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in vero cells
                                                        

- (Peer Reviewed Journal)Derscheid, R.J., van Geelen, A., McGill, J.L., Gallup, J.M., Cihlar, T., Sacco, R.E., Ackermann, M.R. 2013. Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in vero cells. Viruses. 5(11):2881-2897. DOI: 10.3390/v5112881.Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis

- (Abstract Only)Mcgill, J.L., Sacco, R.E., Baldwin, C., Telfer, J.C., Palmer, M.V., Waters, W.R. 2013. Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis [abstract]. Australasian Society of Immunology. Abstract No. 24.Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants

- (Book / Chapter)Sacco, R.E., McGill, J.L., Palmer, M.V., Lippolis, J.D., Reinhardt, T.A., Nonnecke, B.J. 2014. Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants. In: Rosenberg, H.F., Domachowske, J.B., editors. Pneumoviruses and Metapneumoviruses. Basel, Switzerland: MDPI AG. p. 46-69.Proteomic differences between Escherichia coli strains that cause transient versus persistent intramammary infections [abstract]

- (Abstract Only)Development and application of specific cytokine assays in tissue samples from a bottlenose dolphin with hyperinsulinemia
                                                        

- (Peer Reviewed Journal)Eberle, K., Waters, T.E., Jensen, E.D., Venn-Watson, S., Sacco, R.E. 2013. Development and application of specific cytokine assays in tissue samples from a bottlenose dolphin with hyperinsulinemia. Frontiers in Endocrinology. 4:134. DOI: 10.3389/fendo.2013.00134.Respiratory syncytial virus infection in cattle

- (Review Article)Sacco, R.E., McGill, J.L., Pillatzki, A.E., Palmer, M.V., Ackermann, M.R. 2014. Respiratory syncytial virus infection in cattle. Veterinary Pathology. 51(2):427-436. DOI: 10.1177/0300985813501341.Evaluation of enzyme-linked immunosorbent assays for detection of Mycoplasma bovis-Specific antibody in bison sera
                                                        

- (Peer Reviewed Journal)Register, K.B., Sacco, R.E., Olsen, S.C. 2013. Evaluation of enzyme-linked immunosorbent assays for detection of Mycoplasma bovis-Specific antibody in bison sera. Clinical and Vaccine Immunology. 20(9):1405-1409 DOI: 10.1128/CVI.00409-13.Mycoplasma bovis research update
                                                        

- (Trade Journal)Register, K.B., Sacco, R.E., Olsen, S.C. 2013.  Mycoplasma bovis research update. Trade Journal Publication. Available: http://www.bisoncentral.com.Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis
                                                        

- (Peer Reviewed Journal)Reinhardt, T.A., Sacco, R.E., Nonnecke, B.J., Lippolis, J.D. 2013. Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis. Journal of Proteomics. 82:141-154.Differential chemokine and cytokine production by neonatal bovine gamma delta T-cell subsets in response to viral toll-like receptor agonists and in vivo respiratory syncytial virus infection
                                                        

- (Peer Reviewed Journal)McGill, J.L., Nonnecke, B.J., Lippolis, J.D., Reinhardt, T.A., Sacco, R.E. 2013. Differential chemokine and cytokine production by neonatal bovine gamma delta T-cell subsets in response to viral toll-like receptor agonists and in vivo respiratory syncytial virus infection. Immunology. 139(2):227-244.Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature and serum proinflammatory cytokine and haptog

- (Peer Reviewed Journal)Richeson, J.T., Kegley, E.B., Powell, J.G., Schaut, R.G., Sacco, R.E., Ridpath, J.F. 2013. Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature and serum proinflammatory cytokine and haptog. Journal of Animal Science. 91(3):1400-1408 DOI:10.2527/jas.2011-4875.Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants

- (Review Article)Sacco, R.E., McGill, J.L., Palmer, M.V., Lippolis, J.D., Reinhardt, T.A., Nonnecke, B.J. 2012. Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants. Viruses. 4(12):3731-3753.Bovine viral diarrhea virus modulation of monocyte derived macrophages

- (Abstract Only)Vitamin D signaling in the bovine immune system: A model for understanding human vitamin D requirements

- (Peer Reviewed Journal)Nelson, C.D., Reinhardt, T.A., Lippolis, J.D., Sacco, R.E., Nonnecke, B.J. 2012. Vitamin D signaling in the bovine immune system: A model for understanding human vitamin D requirements. Nutrients. 4(3):181-196.Differential expression of cytokines in response to respiratory syncytial virus infection of calves with high or low circulating 25-hydroxyvitamin D3

- (Peer Reviewed Journal)Sacco, R.E., Nonnecke, B.J., Palmer, M.V., Waters, W.R., Lippolis, J.D., Reinhardt, T.A. 2012. Differential expression of cytokines in response to respiratory syncytial virus infection of calves with high or low circulating 25-hydroxyvitamin D3. PLoS One. 7(3):e33074. Available: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033074.Correlating levels of type III secretion and secreted proteins with fecal shedding of Escherichia coli O157:H7 in cattle

- (Peer Reviewed Journal)Sharma, V.K., Sacco, R.E., Kunkle, R.A., Bearson, S.M., Palmquist, D.E. 2012. Correlating levels of type III secretion and secreted proteins with fecal shedding of Escherichia coli O157:H7 in cattle. Infection and Immunity. 80(4):1333-1342.Bovine milk exosome proteome

- (Peer Reviewed Journal)Reinhardt, T.A., Lippolis, J.D., Nonnecke, B.J., Sacco, R.E. 2012. Bovine milk exosome proteome. Journal of Proteomics. 75(5):1486-1492.Characterization of viral replication and the immune response in bison peripheral blood mononuclear cells following in vitro bovine viral diarrhea virus infection

- (Abstract Only)McGill, J.L., Schaut, R.G., Neill, J.D., Olsen, S.C., Ridpath, J.F., Sacco, R.E. 2011. Characterization of viral replication and the immune response in bison peripheral blood mononuclear cells following in vitro bovine viral diarrhea virus infection [abstract]. In: Proceedings of the U.S. Bovine Viral Diarrhea Virus Symposium, November 17-18, 2011, San Diego, California. p. 59.Mechanisms regulating immunity and disease severity following high and low virulence BVDV type 2 infection in neonatal calves

- (Abstract Only)McGill, J.L., Schaut, R.G., Neill, J.D., Ridpath, J.F., Sacco, R.E. 2011. Mechanisms regulating immunity and disease severity following high and low virulence BVDV type 2 infection in neonatal calves [abstract]. In: Proceedings of the U.S. Bovine Viral Diarrhea Virus Symposium, November 17-18, 2011, San Diego, California. p. 67.Bovine viral diarrhea virus modulations of monocyte derived macrophages

- (Abstract Only)Schaut, R.G., McGill, J.L., Neill, J.D., Ridpath, J.F., Sacco, R.E. 2011. Bovine viral diarrhea virus modulations of monocyte derived macrophages [abstract]. In: Proceedings of the U.S. Bovine Viral Diarrhea Virus Symposium, November 17-18, 2011, San Diego, Calfornia. p. 69.Treatment of an intramammary bacterial infection with 25-hydroxyvitamin D3

- (Peer Reviewed Journal)Lippolis, J.D., Reinhardt, T.A., Sacco, R.E., Nonnecke, B.J., Nelson, C.D. 2011. Treatment of an intramammary bacterial infection with 25-hydroxyvitamin D3. PLoS One. 6(10):e25479. Available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184989/pdf/pone.0025479.pdf.Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature, peripheral blood leukocytes and serum

- (Other)Richeson, J.T., Kegley, E.B., Powell, J.G., Galloway, D.L., Hornsby, J.A., Schaut, R.G., Sacco, R.E., Ridpath, J.F. 2012. Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature, peripheral blood leukocytes and serum proinflammatory cytokine and haptoglobin concentrations. Arkansas Animal Science Department Report 2011. AAES Research Series 597. p. 34-39.Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature, peripheral blood leukocytes and serum

- (Abstract Only)Richeson, J.T., Kegley, E.B., Powell, R.G., Schaut, R.G., Sacco, R.E., Ridpath, J.F. 2011. Weaning management of newly received beef calves with or without continuous exposure to a persistently infected bovine viral diarrhea virus pen mate: Effects on rectal temperature, peripheral blood leukocytes and serum proinflammatory cytokine concentrations [abstract]. Joint Annual Meeting American Dairy Science Association-American Society of Animal Science. Journal of Animal Science 89(E-Suppl. 1)/J. Dairy Sci. 94(E-Suppl.1). p. 157. Available: http://www.jtmtg.org/2011/abstracts/0157.PDF.Porcine TLR3 characterization and expression in response to influenza virus and Bordetella bronchiseptica

- (Peer Reviewed Journal)Sacco, R.E., Nicholson, T.L., Waters, T.E., Brockmeier, S. 2011. Porcine TLR3 characterization and expression in response to influenza virus and Bordetella bronchiseptica. Veterinary Immunology and Immunopathology. 142(1-2):57-63.Neonatal and Adult AMphi Upregulate Cytokine Gene Transcription Via p38 MAPK Signaling in Response to RSV

- (Abstract Only)Schaut, R., Levy, N., Sacco, R.E. 2010. Neonatal and Adult AMphi Upregulate Cytokine Gene Transcription Via p38 MAPK Signaling in Response to RSV [abstract]. Autumn Immunology Conference. 39:26.Modeling Bovine Respiratory Syncytial Virus Infection

- (Abstract Only)Sacco, R.E., Waters, W.R., Palmer, M.V., Nonnecke, B.J. 2010. Modeling Bovine Respiratory Syncytial Virus Infection [abstract]. The Association for Veterinary Teaching and Research Work. p. 6.Bovine Viral Diarrhea Virus Modulation of Monocyte Derived Macrophage

- (Abstract Only)Schaut, R.G., Ridpath, J.F., Neill, J.D., Sacco, R.E. 2010. Bovine Viral Diarrhea Virus Modulation of Monocyte Derived Macrophage [abstract]. American Association of Veterinary Laboratory Diagnosticians. p. 241.Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions

- (Peer Reviewed Journal)Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions. Microbial Pathogenesis. 49(5):237-245.Differential Expression of Cytokine Transcripts in Neonatal and Adult Ovine Alveolar Macrophages in Response to Respiratory Syncytial Virus or Toll-Like Receptor Ligation

- (Peer Reviewed Journal)Fach, S.J., Olivier, A., Gallup, J.M., Waters, T.E., Ackermann, M., Lehmkuhl, H.D., Sacco, R.E. 2010. Differential Expression of Cytokine Transcripts in Neonatal and Adult Ovine Alveolar Macrophages in Response to Respiratory Syncytial Virus or Toll-Like Receptor Ligation. Veterinary Immunology and Immunopathology. 136(1-2):55-64.Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions

- (Abstract Only)Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions [abstract]. Conference Research Workers Disease Meeting. Paper No. 130.Signal Regulatory Protein alpha (SIRPalpha)+ Cells in the Adaptive Response to ESAT-6/CFP-10 Protein of Tuberculous Mycobacteria

- (Peer Reviewed Journal)Waters, W.R., Palmer, M.V., Nonnecke, B.J., Thacker, T.C., Estes, D.M., Larsen, M.H., Jacobs, W.R., Andersen, P., Mcnair, J., Minion, F.C., Lyashchenko, K.P., Hewinson, R.G., Vordermeier, H.M., Sacco, R.E. 2009. Signal Regulatory Protein alpha (SIRPalpha)+ Cells in the Adaptive Response to ESAT-6/CFP-10 Protein of Tuberculous Mycobacteria. PLoS One [serial online]. 4(7):e6414. Available: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006414.Laser Capture Microdissection Revisited as a Tool for Transcriptomic Analysis:  Application of an Excel-Based qPCR Preparation Software (PREXCEL-Q)

- (Peer Reviewed Journal)Sow, F.B., Gallup, J.M., Sacco, R.E., Ackermann, M.R. 2009. Laser Capture Microdissection Revisited as a Tool for Transcriptomic Analysis:  Application of an Excel-Based qPCR Preparation Software (PREXCEL-Q). International Journal of Biomedical Science. 5(2):105-124.Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus

- (Peer Reviewed Journal)Brockmeier, S., Lager, K.M., Grubman, M.J., Brough, D.E., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Loving, C.L., Vorwald, A.C., Kehrli Jr, M.E., Lehmkuhl, H.D. 2009. Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus. Viral Immunology. 22(3):173-180.The mononuclear phagocyte system and lymphocytes

- (Book / Chapter)Sacco, R.E. 2009. The Mononuclear Phagocyte System and Lymphocytes. In: Cheville, N.F., editor. Ultrastructural Pathology. 2nd edition. Ames, IA: Wiley Blackwell Press. p. 268-294.Differences in immune response of pigs challenged with a high versus low dose inoculum of porcine reproductive and respiratory syndrome virus

- (Peer Reviewed Journal)Loving, C.L., Brockmeier, S.L., Vincent, A.L., Lager, K.M., Sacco, R.E. 2008. Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus. Viral Immunology. 21(3):315-325.Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica

- (Proceedings)Brockmeier, S., Vincent, A.L., Loving, C.L., Nicholson, T.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica.  In: Proceedings of the 20th International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. 1:10.Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica

- (Abstract Only)Brockmeier, S., Loving, C.L., Nicholson, T.L., Vincent, A.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. American Society for Microbiology Meeting, June 2-4, 2008, Boston, Massachusetts. 2008 CDROM.DNA vaccines against infectious agents: recent strategies for enhancing immune responses

- (Review Article)Sacco, R.E. 2008. DNA vaccines against infectious agents: Recent strategies for enhancing immune responses. Expert Opinion on Therapeutic Patents. 18(4):365-373.Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica

- (Abstract Only)Brockmeier, S., Vincent, A.L., Nicholson, T.L., Sacco, R.E., Palmer, M.V. 2007. Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. In: United States Japan Natural Resources Animal and Avian Health Panel, December 5, 2007, Tsukuba, Japan. p. 25.Veterinary Applications for Monitoring Mononuclear Cell Proliferation Using Cell Tracking Dyes

- (Peer Reviewed Journal)Waters, W.R., Sacco, R.E. 2007. Veterinary Applications for Monitoring Mononuclear Cell Proliferation Using Cell Tracking Dyes. Immunological Investigations. 36(5-6):887-908.Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene

- (Peer Reviewed Journal)Register, K.B., Sacco, R.E., Brockmeier, S. 2007. Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene. Vaccine. 25(32):6118-28.IL-4 induction in RSV-infected macrophages: examining the role of NFAT family members

- (Abstract Only)Levy, N.A., Fach, S.J., Sacco, R.E. 2007. IL-4 induction in RSV-infected macrophages: examining the role of NFAT family members [abstract]. American Association of Immunologists Proceedings. 178:B128.Viruses as Predisposing Factors to Bacterial Pneumonia

- (Abstract Only)Lehmkuhl, H.D., Briggs, R.E., Sacco, R.E., Tatum, F.M. 2007. Viruses as Predisposing Factors to Bacterial Pneumonia [abstract]. Respiratory Disease in Mountain Sheep: Knowledge Gaps and Future Research. p. 154.Immune Response in Mice and Swine to a DNA Vaccine Derived from the Pasteurella multocida toxin gene

- (Abstract Only)Register, K.B., Sacco, R.E., Brockmeier, S. 2007. Immune Response in Mice and Swine to a DNA Vaccine Derived from the Pasteurella multocida toxin gene[abstract]. American Society for Microbiology Meeting. May 21-25, 2007, Toronto, Canada. 2007 CD-ROM.Coinfection with Swine Influenza Virus and Bordetella bronchiseptica in Pigs

- (Abstract Only)Brockmeier, S., Vincent, A.L., Sacco, R.E., Nicholson, T.L., Palmer, M.V. 2007. Coinfection with Swine Influenza Virus and Bordetella bronchiseptica in Pigs [abstract]. American Society for Microbiology Meeting, May 21-25,2007, Toronto, Canada. 2007 CD-ROM.INNATE CYTOKINE RESPONSES IN PORCINE MACROPHAGE POPULATIONS: EVIDENCE FOR DIFFERENTIAL RECONGITION OF DSRNA

- (Peer Reviewed Journal)Loving, C.L., Brockmeier, S., Wenjun, M., Richt, J., Sacco, R.E. 2006. Innate Cytokine Responses in Porcine Macrophage Populations: Evidence for Differential Recongition of dsRNA. Journal of Immunology. 177:8432-8439.NEONATAL OVINE PULMONARY DENDRITIC CELLS SUPPORT BRSV REPLICATION WITH ENHANCED IL-4 AND IL-10 GENE TRANSCRIPTS

- (Peer Reviewed Journal)Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2007. Neonatal Ovine Pulmonary Dendritic Cells Support BRSV Replication with Enhanced IL-4 and IL-10 Gene Transcripts. Viral Immunology. 20(1):119-130.Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus

- (Peer Reviewed Journal)Loving, C.L., Brockmeier, S., Sacco, R.E. 2006. Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus. Immunology. 120:217-229.Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus

- (Abstract Only)Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceedings of the 87th Conference of Research Workers in Animal Diseases, December 3-5, 2006. Chicago, Illinois. p.124.Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus

- (Abstract Only)Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceeding of the International PRRS Symposium, December 1-2, 2006, Chicago, Illinois. p. 27.IMMUNE RESPONSES OF ELK TO INITITAL AND BOOSTER VACCINATIONS WITH BRUCELLA ABORTUS STRAIN RB51 OR 19

- (Peer Reviewed Journal)Olsen, S.C., Fach, S.J., Palmer, M.V., Sacco, R.E., Stoffregen, W.C., Waters, W.R. 2006. Immune Responses of Elk to Initital and Booster Vaccinations with Brucella abortus Strain RB51 or 19. Clinical and Vaccine Immunology. 13(10):1098-1103.DIFFERENTIAL REGULATION OF TYPE I INTERFERON ACTIVATION IN MACROPHAGES

- (Abstract Only)Loving, C.L., Brockmeier, S., Sacco, R.E. 2006. Differential regulation of type I interferon activation in macrophages [abstract]. American Association of Immunologists Proceedings. 249:43-44.PULMONARY DENDRITIC CELLS ISOLATED FROM NEONATAL AND ADULT OVINE LUNG TISSUE

- (Peer Reviewed Journal)Fach, S.J., Brockmeier, S., Hobbs, L.A., Lehmkuhl, H.D., Sacco, R.E. 2006. Pulmonary dendritic cells isolated from neonatal and adult ovine lung tissue. Veterinary Immunology and Immunopathology. 112(3-4):171-82.COMPARATIVE NITRIC OXIDE PRODUCTION OF LPS-STIMULATED MONOCYTE-DERIVED MACROPHAGES FROM OVIS CANADENSIS AND OVIS ARIES

- (Peer Reviewed Journal)Sacco, R.E., Waters, W.R., Rudolph, K.M., Drew, M.L. 2006. Comparative nitric oxide production of LPS-stimulated monocyte-derived macrophages from Ovis canadensis and Ovis aries. Comparative Immunology Microbiology and Infectious Diseases. 29(1):1-11.NEONATAL LAMB RESPIRATORY TRACT DENDRITIC CELLS AND THE EFFECTS OF RSV INFECTION

- (Abstract Only)Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2005. Neonatal lamb respiratory tract dendritic cells and the effects of RSV infection [abstract]. Federation of American Societies for Experimental Biology Conference. 19:A403.PRRS VIRUS PRODUCTIVELY INFECTS MONOCYTE-DERIVED DENDRITIC CELLS AND INDUCES PRODUCTION OF INNATE ANTIVIRAL MEDIATORS

- (Abstract Only)Loving, C.L., Brockmeier, S., Sacco, R.E. 2005. Prrs virus productively infects monocyte-derived dendritic cells and induces production of innate antiviral mediators. Federation of American Societies for Experimental Biology Conference. 19:A404.EFFECT OF BRSV INFECTION IN NEONATAL LAMBS ON RESPIRATORY TRACT DENDRITIC CELLS

- (Abstract Only)Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2004. Effect of BRSV infection in neonatal lambs on respiratory tract dendritic cells [abstract]. Autumn Immunology Conference. p. 52.INNATE IMMUNITY OF RESPIRATORY EPITHELIA:  EFFECTS OF PRETERM BIRTH AND RESPIRATORY SYNCYTIAL VIRUS INFECTION

- (Abstract Only)Ackermann, M.R., Meyerholz, D.K., Grubor, B., Lehmkuhl, H.D., Sacco, R.E., Gallup, J.M., Derscheid, R., Lazic, T., Fach, S., Kawashima, K. 2004. Innate immunity of respiratory epithelia: effects of preterm birth and respiratory syncytial virus infection [abstract]. Conference of Research Workers in Animal Diseases. p. 136.INCREASED SEVERITY OF BOVINE RESPIRATORY SYNCYTIAL VIRUS INFECTION IN PRETERM LAMBS

- (Abstract Only)Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. 2004. Increased severity of bovine respiratory syncytial virus infection in preterm lambs [abstract]. Bi-Annual All-Iowa Virology Symposium. Paper No. 12.COMPARISON OF THE EXPRESSED PORCINE VBETA AND JBETA REPERTOIRE OF THYMOCYTES AND PERIPHERAL T-CELLS

- (Peer Reviewed Journal)Butler, J.E., Wertz, N., Sun, J., Sacco, R.E. 2005. Comparison of the expressed porcine vbeta and jbeta repertoire of thymocytes and peripheral t-cells. Immunology. 114:184-193.REDUCED CLEARANCE OF RESPIRATORY SYNCYTIAL VIRUS IN A PRETERM LAMB MODEL

- (Peer Reviewed Journal)Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. 2004. Reduced clearance of respiratory syncytial virus in a preterm lamb model. Microbes and Infection. 6(14):1312-1319.IMMUNE RESPONSE TO A DNA VACCINE DERIVED FROM THE PASTEURELLA MULTOCIDA TOXIN GENE

- (Proceedings)Register, K.B., Sacco, R.E., Brockmeier, S. 2004.  Immune response to a dna vaccine derived from the pasteurella multocida toxin gene. Pig Veterinary Society International Congress Proceedings. p. 200.RESPIRATORY SYNCYTIAL VIRUS INFECTION IN PRETERM LAMBS

- (Abstract Only)Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Ensley, D., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. Respiratory syncytial virus infection in preterm lambs. 2004. Presented at FASEB Meeting. Abstract No. 1074.THE EFFECTS OF PASTEURELLA MULTOCIDA TOXIN (PMT) ON EARLY MURINE B-LINEAGE CELLS

- (Abstract Only)Loving, C.L., Sacco, R.E. 2003. The effects of pasteurella multocida toxin (pmt) on early murine b-lineage cells. Autumn Immunology Conference Proceedings.  Abstract No. 140, p. 54.THE EFFECTS OF PASTEURELLA MULTOCIDA TOXIN (PMT) ON EARLY MURINE B-LINEAGE CELLS

- (Abstract Only)Loving, C.L., Sacco, R.E. 2003. The effects of Pasteurella multocida toxin (pmt) on early murine b-lineage cells. Immunology Research Workshop. December 2, 2003.ANALYSIS OF LYMPHOCYTES ISOLATED FROM WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FAWNS

- (Abstract Only)Fach, S.J., Waters, W.R., Palmer, M.V., Davis, W.C., Sacco, R.E. 2003. Analysis of lymphocytes isolated from white-tailed deer (odocoileus virginianus) fawns. Immunology Research Workshop. December 2, 2003.RE-EMERGENCE OF BORDETELLA BRONCHISPETICA DURING THE RECENT SEAL MORBILLIVIRUS OUTBREAK

- (Proceedings)FOSTER, G., REGISTER, K.B., SACCO, R.E., PATTERSON, I.P. RE-EMERGENCE OF BORDETELLA BRONCHISPETICA DURING THE RECENT SEAL MORBILLIVIRUS OUTBREAK. PROCEEDINGS OF THE SCOTTISH AGRICULTURAL COLLEGE OF VETERINARY SCIENCES CONFERENCE. SEPTEMBER 10-11, 2003. p. 21.DEFENSIN-INDUCED ADAPTIVE IMMUNITY IN MICE AND ITS POTENTIAL IN PREVENTING PERIODONTAL DISEASE

- (Peer Reviewed Journal)Brogden, K.A., Heidari, M., Sacco, R.E., Palmquist, D.E., Guthmiller, J.M., Johnson, G.K., Jia, H.P., Tack, B.F., Mccray, P.B. 2003. Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease. Oral Microbiology and Immunology. Vol. 18:95-99.COMPARISON BETWEEN RIBOTYPING AND RESTRICTION ENZYME ANALYSIS FOR INTER- AND INTRASPECIES DISCRIMINATION OF BORDETELLA AVIUM AND BORDETELLA HINZII

- (Peer Reviewed Journal)REGISTER, K.B., SACCO, R.E., NORDHOLM, G.E. COMPARISON OF RIBOTYPING AND RESTRICTION ENZYME ANALYSIS FOR INTER- AND INTRASPECIES DISCRIMINATION OF BORDETELLA AVIUM AND BORDETELLA HINZII. JOURNAL OF CLINICAL MICROBIOLOGY. 2003. v. 41(4). p. 1512-1519.IMMUNE RESPONSES OF ELK TO MYCOBACTERIUM BOVIS BACILLUS CALMETTE GUERIN VACCINATION

- (Peer Reviewed Journal)Waters, W.R., Palmer, M.V., Olsen, S.C., Sacco, R.E., Whipple, D.L. 2003. Immune responses of elk to mycobacterium bovis bacillus calmette guerin vaccination. Vaccine.  Vol. 21(13-14), p. 1518-1526.DEFENSIN INDUCED ADAPTIVE IMMUNITY IN MICE AND ITS POTENTIAL IN PREVENTING PERIODONTAL DISEASE

- (Peer Reviewed Journal)BROGDEN, K.A., HEIDARI, M., SACCO, R.E., PALMQUIST, D.E., GUTHMILLER, J.M., JOHNSON, G.K., JIA, H.P., TACK, B.F., MCCRAY, JR., P.B. DEFENSIN-INDUCED ADAPTIVE IMMUNITY IN MICE AND ITS POTENTIAL IN PREVENTING PERIODONTAL DISEASE. ORAL MICROBIOLOGY AND IMMUNOLOGY. 2003. v. 18. p. 95-99.ANALYSIS OF LYMPHOCYTES ISOLATED FROM WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FAWNS

- (Abstract Only)BHUR, A VIRULENCE-ASSOCIATED OUTER MEMBRANE PROTEIN OF BORDETELLA AVIUM, IS REQUIRED FOR THE ACQUISITION OF IRON FROM HEME AND HEMOPROTEINS

- (Peer Reviewed Journal)MURPHY, E.R., SACCO, R.E., DICKENSON, A., METZGER, D.J., HU, Y., ORNDORFF, P.E., CONNELL, T.D. BHUR, A VIRULENCE-ASSOCIATED OUTER MEMBRANE PROTEIN OF BORDETELLA AVIUM, IS REQUIRED FOR THE ACQUISITION OF IRON FROM HEME AND HEMOPROTEINS. INFECTION AND IMMUNITY. 2002. v. 70(10). p. 5390-5403.INDUCTION OF TH2-LIKE IMMUNE RESPONSES BY C3H MICE BEARING A DEFINED FLORA FOLLOWING ONSET OF COLITIS

- (Abstract Only)ESTABLISHED TH1 GRANULOMATOUS RESPONSES INDUCED BY ACTIVE MYCOBACTERIUM AVIUM INFECTION SWITCH TO TH2 FOLLOWING CHALLENGE WITH SCHISTOSOMA MANSONI

- (Peer Reviewed Journal)SACCO, R.E., HAGEN, M., SANDOR, M., WEINSTOCK, J.V., LYNCH, R.G. ESTABLISHED TH1 GRANULOMATOUS RESPONSES INDUCED BY ACTIVE MYCOBACTERIUM AVIUM INFECTION SWITCH TO TH2 FOLLOWING CHALLENGE WITH SCHISTOSOMA MANSONI. Clinical Immunology. 2002. v. 104(3). p. 274-281.ANALYSIS OF MITOGEN-STIMULATED LYMPHOCYTE SUBSET PROLIFERATION AND NITRIC  OXIDE PRODUCTION BY PERIPHERAL BLOOD MONONUCLEAR CELLS OF CAPTIVE ELK      (CERVUS ELAPHUS)

- (Peer Reviewed Journal)NITRIC OXIDE PRODUCTION AS AN INDICATION OF MYCOBACTERIUM BOVIS INFECTION  OF WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS)

- (Abstract Only)NITRIC OXIDE PRODUCTION AS AN INDICATION OF MYCOBACTERIUM BOVIS INFECTION  OF WHITE-TAILED DEER

- (Peer Reviewed Journal)CHARACTERIZATION OF BIGHORN SHEEP (OVIS CANADENSIS) MACROPHAGES USING      IMMUNOHISTOCHEMICAL, FLOW CYTOMETRIC AND FUNCTIONAL ASSAYS (POSTER         PRESENTATION FOR THE 82ND CONFERENCE OF RESEARCH WORKERS IN ANIMAL DISEASE)

- (Abstract Only)PHENOTYPIC ANALYSIS OF LYMPHOCYTES ISOLATED FROM WHITE-TAILED DEER         (ODOCOILEUS VIRGINIANUS) FAWNS USING THREE-COLOR FLOW CYTOMETRY (POSTER    PRESENTATION AT THE 82ND CONFERENCE OF RESEARCH WORKERS IN ANIMAL DISEASE)

- (Abstract Only)BETA DEFENSIN-INDUCED ADAPTIVE IMMUNE RESPONSE TO OVALBUMIN IN MICE        (POSTER PRESENTATION FOR THE 101ST ASM ANNUAL MEETING, MAY 20-24, 2001)

- (Abstract Only)IDENTIFICATION OF NEW MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II            RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN A CLOSED EXPERIMENTAL         LINE OF BELTSVILLE SMALL WHITE TURKEYS

- (Research Notes)GALLINACIN-3, AN INDUCIBLE EPITHELIAL BETA DEFENSIN OF THE CHICKEN

- (Peer Reviewed Journal)RESTRICTION ENDONUCLEASE ANALYSIS DISCRIMNATES BORDETELLA BRONCHISEPTICA   ISOLATES

- (Peer Reviewed Journal)FLOW CYTOMETRIC ANALYSIS OF COLONIC AND SMALL INTESTINAL MUCOSAL           LYMPHOCYTES OBTAINED BY ENDOSCOPIC BIOPSY IN THE HEALTHY DOG

- (Peer Reviewed Journal)ANTIGEN-SPECIFIC PROLIFERATION OF PORCINE CD8 ALPHA ALPHA CELLS TO AN      EXTRACELLULAR BACTERIAL PATHOGEN

- (Peer Reviewed Journal)REDUCTION IN INFLAMMATION FOLLOWING BLOCKADE OF CD18 OR CD29 ADHESIVE      PATHWAYS DURING THE ACUTE PHASE OF A SPIROCHETAL-INDUCED COLITIS IN MICE

- (Peer Reviewed Journal)RIBOTYPING AND RESTRICTION ENDONUCLEASE ANALYSIS REVEAL A NOVEL CLONE      OF BORDETELLA BRONCHISEPTICA IN SEALS

- (Peer Reviewed Journal)B CELLS ARE REQUIRED FOR THE INDUCTION OF INTESTINAL INFLAMMATORY LESIONS  IN TCR ALPHA-DEFICIENT MICE PERSISTENTLY INFECTED WITH CRYPTOSPORIDIUM     PARVUM

- (Peer Reviewed Journal)RESTRICTION ENZYME ANALYSIS OF BORDETELLA BRONCHISPETICA ISOLATES

- (Abstract Only)BORDETELLA AVIUM DERMONECROTIC TOXIN INDUCES APOPTOSIS IN LYMPHOID TISSUES

- (Abstract Only)ANTIGEN-SPECIFIC PROLIFERATION OF PORCINE CD8 ALPHA ALPHA T CELLS

- (Abstract Only)POULT NEPHROPATHY INDUCED BY A BORDETELLA AVIUM TOXIN

- (Proceedings)RESTRICTION ENZYME ANALYSIS AND RIBOTYPING DISTINGUISH BORDETELLA AVIUM    AND BORDETELLA HINZII ISOLATES

- (Peer Reviewed Journal)GENETIC VARIATION IN RESPONSE OF TURKEYS TO EXPERIMENTAL INFECTION         WITH BORDETELLA AVIUM (RESEARCH NOTE)

- (Peer Reviewed Journal)BORDETELLA AVIUM DERMONECROTIC TOXIN CAUSES LYMPHOID LESIONS IN MICE       (ORAL PRESENTATION FOR THE AVMA/AAAP MTG., JULY 1999)

- (Abstract Only)CELLULAR IMMUNE RESPONSES OF PIGS INDUCED BY VACCINATION WITH EITHER       A WHOLE CELL SONICATE OR PEPSIN-DIGESTED SERPULINA HYODYSENTERIAE BACTERIN

- (Peer Reviewed Journal)CRYPTOSPORIDIUM PARVUM-INDUCED INFLAMMATORY BOWEL DISEASE OF               TCR-BETA X TCR-DELTA-DEFICIENT MICE

- (Peer Reviewed Journal)SYSTEMIC AND MUCOSAL IMMUNE RESPONSES OF PIGS TO PARENTERAL                IMMUNIZATION WITH A PEPSIN-DIGESTED SERPULINA HYODYSENTERIAE BACTERIN

- (Peer Reviewed Journal)MODULATION OF THE LYMPHOCYTE REPERTOIRE IN MICE FOLLOWING ADMINISTRATION   OF BORDETELLA AVIUM DERMONECROTIC TOXIN (POSTER PRESENTATION FOR THE       99TH ASM GEN. MEETING, MAY 30 - JUNE 3, 1999)

- (Abstract Only)ROLE OF ACUTE PHASE CYTOKINES AND LEUKOCYTIC INFILTRATION IN A MURINE      MODEL OF SPIROCHETE-INDUCED COLITIS (POSTER PRESENTATION AT THE KEYSTONE   SYMPOSIA, SANTA FE, NM, JANUARY 1999)

- (Proceedings)ANTIGEN-SPECIFIC B CELL UNRESPONSIVENESS INDUCED BY CHRONIC MYCOBACTERIUM  AVIUM SUBSP. PARATUBERCULOSIS INFECTION IN CATTLE

- (Peer Reviewed Journal)ANTIGEN-SPECIFIC B CELL UNRESPONSIVENESS INDUCED BY CHRONIC MYCOBACTERIUM  AVIUM SUBSP PARATUBERCULOSIS INFECTION OF CATTLE

- (Abstract Only)UTILITY OF DNA FINGERPRINTING TO DISTINGUISH BORDETELLA AVIUM,             BORDETELLA HINZII AND ALCALIGENES FAECALIS ISOLATES (ORAL PRESENTATION FOR THE 33RD UNITED STATES-JAPAN NATURAL RESOURCES MYCOPLASMOSIS MTG. (UJNR)

- (Abstract Only)USE OF PKH2 TO DEMONSTRATE ANTIGEN-SPECIFIC B CELL UNRESPONSIVENESS        IN CATTLE CHRONICALLY INFECTED WITH MYCOBACTERIUM AVIUM SUBSP.             PARATUBERCULOSIS

- (Abstract Only)CELLULAR IMMUNE RESPONSES OF PIGS TO PARENTERAL VACCINATION WITH           A SERPULINA HYODYSENTERIAE WHOLE CELL SONICATE OR PEPSIN-DIGEST BACTERIN

- (Abstract Only)DNA FINGERPRINTING OF BORDETELLA AVIUM AND BORDETELLA HINZII ISOLATES

- (Abstract Only)CRYPTOSPORIDIUM PARVUM INITIATES INFLAMMATORY BOWEL DISEASE IN GERMFREE    T CELL RECEPTOR-ALPHA-DEFICIENT MICE

- (Peer Reviewed Journal)FLOW CYTOMETRIC ANALYSIS OF CANINE COLONIC MUCOSAL LYMPHOCYTES OBTAINED    FROM ENDOSCOPIC BIOPSIES

- (Peer Reviewed Journal)SUSCEPTIBILITY OF CONVALESCENT TURKEYS TO PULMONARY ASPERGILLOSIS          (RESEARCH NOTE)

- (Research Notes)INFECTION WITH CRYPTOSPORIDIUM PARVUM INITIATES INFLAMMATORY BOWEL DISEASE IN GERM-FREE TCR-ALPHA-DEFICIENT MICE

- (Abstract Only)


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