| Columbia      Laboratories, Inc.                                                                                                                                                                                                                                                                                                                |
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| 2008                                                                                                                                                                                                                                                                                                                                            |
| Name:                                                                                                                                                                                                                                                                                                                                           |
| Address:                                                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                            |
| City      & State:                                                                                                                                                                                                                                                                                                                          |
| Grant      Number:                                                                                                                                                                                                                                                                                                                              |   | Grant      Date: | /2008 | Yearly      Vesting Schedule |
|                                                                                                                                                                                                                                                                                                                                            | Beginning | Percent | Shares |
| Option      Type:                                                                                                                                                                                                                                                                                                                               | ISO      or NQSO | Shares      Granted: |   | Year      1 | 25% | 25,000 |
|                                                                                                                                                                                                                                                                                                                                            | Year      2 | 25% | 25,000 |
| Grant      Price:                                                                                                                                                                                                                                                                                                                               |   |   |   | Year      3 | 25% | 25,000 |
|                                                                                                                                                                                                                                                                                                                                            | Year      4 | 25% | 25,000 |
| Vesting      Update:                                                                                                                                                                                                                                                                                                                            | /09      @ 25.00% | Expiration      Date: | /2015 |   |
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|                                                                                                                                                                                                                                                                                                                                            |
| NOTICE      OF GRANT OF A STOCK OPTION FOR THE                                                                                                                                                                                                                                                                                                  |
| PURCHASE      OF SHARES OF THE COMMON STOCK OF                                                                                                                                                                                                                                                                                                  |
|                                                                                                                                                                                                                                                                                                                                            |
| Columbia      Laboratories, Inc.                                                                                                                                                                                                                                                                                                                |
|                                                                                                                                                                                                                                                                                                                                            |
| Robert      S. Mills or James A. Meer                                                                                                                                                                                                                                                                                                           |
| CEO      / President/ Sr. Vice President CFO & Treasurer                                                                                                                                                                                                                                                                                    |
|                                                                                                                                                                                                                                                                                                                                            |
| By      affixing your signature to this Notice, you acknowledge receipt of a copy      of the Agreement and the Plan to which the Agreement and this Stock Option      Grant is subject and agree that the Options Granted hereunder shall be      subject to such Plan and Agreement and shall be governed by their terms      and provisions. |
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| ___________________________                                                                                                                                                                                                                                                                                                                     |   | ___________ |   |
| Name:                                                                                                                                                                                                                                                                                                                                           |   | Date |
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