Federal Register / Vol. 86, No. 157 / Wednesday, August 18, 2021 / Notices 46259 

global disease burden is hampered by 

remarkably high treatment costs and a 

high number of undiagnosed infections. 

Moreover, a significant number of 

patients develop resistance and 

additional treatment modalities may be 

needed to dramatically reduce the 

worldwide incidence of HCV infection. 

The subject cell line may be a useful 

tool for studying the mechanism of HCV 

cellular entry and replication and could 

be incorporated into an in vitro assay to 

measure the effectiveness of novel HCV 

targeted therapies or as a system for 

improved propagation of HCV in 

culture. 

By overexpressing TACSTD2 in 

Huh7.5 cells, scientists at the National 

Institute of Allergy and Infectious 

Diseases (NIAID) discovered that they 

could restore the cellular localization of 

two host cell HCV-entry factors that 

become dysregulated in hepatocellular 

carcinoma (HCC) cells. Overexpression 

of TACSTD2 makes Huh7.5 cells more 

broadly permissive to infection and 

replication by multiple HCV genotypes 

in comparison to the canonical Huh7.5 

cell model. HCV does not replicate in 

malignant HCC cells, possibly caused in 

part by downregulation of TACSTD2 

expression. 

This technology is available for 

licensing for commercial development 

in accordance with 35 U.S.C. 209 and 37 

CFR part 404. 

Potential Commercial Applications 

• Cell line to study hepatitis C virus

infection and replication or propagate 

HCV in culture. 

• Cell line to study cancer.

Development Stage 

• Material.

Inventors: Patrizia Farci and Vandana

Sekhar (NIAID). 

Publication: Sekhar V, Pollicino T, 

Diaz G, Engle RE, Alayli F, Melis M, 

Kabat J, Tice A, Pomerenke A, AltanBonnet N, Zamboni F, Lusso P, Emerson 

SU, and Farci P. (2018) Infection with 

hepatitis C virus depends on TACSTD2, 

a regulator of claudin-1 and occludin 

highly downregulated in hepatocellular 

carcinoma. PLoS Pathog 14: e1006916. 

doi: 10.1371/journal.ppat.1006916. 

Licensing Contact: To license this 

technology, please contact Elizabeth 

Pitts, Ph.D., 240–669–5299; 

elizabeth.pitts@nih.gov, and reference 

E–040–2020. 

Dated: August 12, 2021. 

Surekha Vathyam, 

Deputy Director, Technology Transfer and 

Intellectual Property Office, National Institute 

of Allergy and Infectious Diseases. 

[FR Doc. 2021–17687 Filed 8–17–21; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Cancer Institute; Notice of 

Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended, notice is hereby given of a 

meeting of the National Cancer 

Advisory Board. 

The meeting will be held as a virtual 

meeting and is open to the public as 

indicated below. Individuals who plan 

to view the virtual meeting and need 

special assistance or other reasonable 

accommodations to view the meeting 

should notify the Contact Person listed 

below in advance of the meeting. The 

meeting will be videocast and can be 

accessed from the NIH Videocasting and 

Podcasting website (http://

videocast.nih.gov/). 

A portion of the National Cancer 

Advisory Board meeting will be closed 

to the public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Cancer 

Advisory Board. 

Date: August 31, 2021. 

Open: 1:00 p.m. to 3:10 p.m. 

Agenda: NCAB Subcommittee Meetings— 

Subcommittee on Planning and Budget and 

Ad Hoc Subcommittee on Global Cancer 

Research. 

Place: National Cancer Institute—Shady 

Grove, 9609 Medical Center Drive, Rockville, 

MD 20850 (Virtual Meeting). 

Name of Committee: National Cancer 

Advisory Board. 

Date: September 1, 2021. 

Open: 1:00 p.m. to 4:15 p.m. 

Agenda: Director’s and Program reports 

and presentations; business of the Board. 

Closed: 4:25 p.m. to 5:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Cancer Institute—Shady 

Grove, 9609 Medical Center Drive, Rockville, 

MD 20850 (Virtual Meeting). 

Contact Person: Paulette S. Gray, Ph.D., 

Director, Division of Extramural Activities, 

National Cancer Institute—Shady Grove, 

National Institutes of Health, 9609 Medical 

Center Drive, 7th Floor, Room 7W444, 

Bethesda, MD 20892, 240–276–6340, grayp@

mail.nih.gov. 

Any interested person may file written 

comments with the committee by forwarding 

the statement to the Contact Person listed on 

this notice. The statement should include the 

name, address, telephone number and when 

applicable, the business or professional 

affiliation of the interested person. 

Information is also available on the 

Institute’s/Center’s home page: NCAB: 

https://deainfo.nci.nih.gov/advisory/ncab/ 

ncabmeetings.htm, where an agenda and any 

additional information for the meetings will 

be posted when available. 

This notice is being published less than 15 

days prior to the meeting due to scheduling 

difficulties. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.392, Cancer Construction; 

93.393, Cancer Cause and Prevention 

Research; 93.394, Cancer Detection and 

Diagnosis Research; 93.395, Cancer 

Treatment Research; 93.396, Cancer Biology 

Research; 93.397, Cancer Centers Support; 

93.398, Cancer Research Manpower; 93.399, 

Cancer Control, National Institutes of Health, 

HHS) 

Dated: August 13, 2021. 

Melanie J. Pantoja, 

Program Analyst, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2021–17742 Filed 8–17–21; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Nursing Research; 

Notice of Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended, notice is hereby given of a 

meeting of the National Advisory 

Council for Nursing Research. 

The meeting will be open to the 

public as indicated below via videocast. 

The URL link to this meeting is https:// 

videocast.nih.gov/watch=42425. 

Individuals who plan to attend and 

need special assistance, such as sign 

language interpretation or other 

reasonable accommodations, should 

notify the Contact Person listed below 

in advance of the meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Advisory 

Council for Nursing Research. 

Date: September 14, 2021. 

Open: 11:00 a.m. to 3:30 p.m. 


jbell on DSKJLSW7X2PROD with NOTICES
46260 Federal Register / Vol. 86, No. 157 / Wednesday, August 18, 2021 / Notices 

Agenda: Discussion of Program Policies 

and Issues. 

Place: National Institutes of Health, 

Building 31, 9000 Rockville Pike, Bethesda, 

MD 20892 (Virtual Meeting). 

Closed: 3:30 p.m. to 5:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 

Building 31, 9000 Rockville Pike, Bethesda, 

MD 20892 (Virtual Meeting). 

Contact Person: Susan E. Old, Ph.D., 

Acting Director, Division of Extramural 

Science Programs, National Institutes of 

Health, NINR, Bethesda, MD 20892–9824, 

(301) 496–7291, oldse@mail.nih.gov. 

Any interested person may file written 

comments with the committee by forwarding 

the statement to the Contact Person listed on 

this notice. The statement should include the 

name, address, telephone number and when 

applicable, the business or professional 

affiliation of the interested person. 

Information is also available on the 

Institute’s/Center’s home page: https://

www.ninr.nih.gov/aboutninr/nacnr where an 

agenda and any additional information for 

the meeting will be posted when available. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.361, Nursing Research, 

National Institutes of Health, HHS) 

Dated: August 13, 2021. 

Melanie J. Pantoja, 

Program Analyst, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2021–17744 Filed 8–17–21; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HOMELAND 

SECURITY 

U.S. Citizenship and Immigration 

Services 

[OMB Control Number 1615–NEW] 

Agency Information Collection 

Activities; New Collection: Petition for 

Nonimmigrant Worker: H–2A 

Classification and Petition for 

Nonimmigrant Worker: H–2B 

Classification 

AGENCY: U.S. Citizenship and 

Immigration Services, Department of 

Homeland Security. 

ACTION: 60-Day notice. 

SUMMARY: The Department of Homeland 

Security (DHS), U.S. Citizenship and 

Immigration Services (USCIS) invites 

the general public and other Federal 

agencies to comment upon this 

proposed new collection of information. 

In accordance with the Paperwork 

Reduction Act (PRA) of 1995, the 

information collection notice is 

published in the Federal Register to 

obtain comments regarding the nature of 

the information collection, the 

categories of respondents, the estimated 

burden (i.e., the time, effort, and 

resources used by the respondents to 

respond), the estimated cost to the 

respondent, and the actual information 

collection instruments. 

DATES: Comments are encouraged and 

will be accepted for 60 days until 

October 18, 2021. 

ADDRESSES: All submissions received 

must include the OMB Control Number 

1615–NEW in the body of the letter, the 

agency name and Docket ID USCIS– 

2021–0017. Submit comments via the 

Federal eRulemaking Portal website at 

https://www.regulations.gov under eDocket ID number USCIS–2021–0017. 

FOR FURTHER INFORMATION CONTACT: 

USCIS, Office of Policy and Strategy, 

Regulatory Coordination Division, 

Samantha Deshommes, Chief, telephone 

number (240) 721–3000 (This is not a 

toll-free number. Comments are not 

accepted via telephone message). Please 

note contact information provided here 

is solely for questions regarding this 

notice. It is not for individual case 

status inquiries. Applicants seeking 

information about the status of their 

individual cases can check Case Status 

Online, available at the USCIS website 

at https://www.uscis.gov, or call the 

USCIS Contact Center at 800–375–5283 

(TTY 800–767–1833). 

SUPPLEMENTARY INFORMATION: 

Comments 

USCIS is separating Form I–129, 

Petition for Nonimmigrant Worker, 

(OMB control number 1615–0009) into 

several individual forms. These new 

forms will combine information from 

the main Form I–129 with information 

from the current Supplements to create 

unique forms tailored to specific 

nonimmigrant classifications. USCIS 

believes separating the current Form I– 

129 into several individual forms will 

consolidate and simplify the 

information collection requirements for 

respondents. 

USCIS is creating Form I–129H2A, 

Petition for Nonimmigrant Worker: H– 

2A Classification, and Form I–129H2B, 

Petition for Nonimmigrant Worker: H– 

2B Classification. 

Form I–129H2A will collect 

information for the H–2A nonimmigrant 

program. The H–2A program allows 

U.S. employers or U.S. agents who meet 

specific regulatory requirements to bring 

noncitizens to the United States to fill 

temporary agricultural jobs. 

Form I–129H2B will collect 

information for the H–2B nonimmigrant 

program. The H–2B program allows U.S. 

employers or U.S. agents who meet 

specific regulatory requirements to bring 

noncitizens to the United States to fill 

temporary nonagricultural jobs. 

USCIS will request approval of Form 

I–129H2A and Form I–129H2B from 

OMB as a new information collection. 

USCIS previously submitted these forms 

to OMB for approval during the 2020 

USCIS Fee Rule; however, this rule was 

enjoined and therefore the approval is 

not in effect. USCIS has determined that 

the creation of this new information 

collection does not require rulemaking 

and is therefore proceeding to seek 

public comments on Form I–129H2A 

and Form I–129H2B via a notice of 

information collection published in the 

Federal Register in accordance with the 

Paperwork Reduction Act, 44 U.S.C. 

3501–3521. 

You may access the information 

collection instrument with instructions 

or additional information by visiting the 

Federal eRulemaking Portal site at: 

https://www.regulations.gov and 

entering USCIS–2021–0017 in the 

search box. All submissions will be 

posted, without change, to the Federal 

eRulemaking Portal at https://

www.regulations.gov, and will include 

any personal information you provide. 

Therefore, submitting this information 

makes it public. You may wish to 

consider limiting the amount of 

personal information that you provide 

in any voluntary submission you make 

to DHS. DHS may withhold information 

provided in comments from public 

viewing that it determines may impact 

the privacy of an individual or is 

offensive. For additional information, 

please read the Privacy Act notice that 

is available via the link in the footer of 

https://www.regulations.gov. 

Written comments and suggestions 

from the public and affected agencies 

should address one or more of the 

following four points: 

(1) Evaluate whether the proposed 

collection of information is necessary 

for the proper performance of the 

functions of the agency, including 

whether the information will have 

practical utility; 

(2) Evaluate the accuracy of the 

agency’s estimate of the burden of the 

proposed collection of information, 

including the validity of the 

methodology and assumptions used; 

(3) Enhance the quality, utility, and 

clarity of the information to be 

collected; and 

(4) Minimize the burden of the 

collection of information on those who 

are to respond, including through the 

use of appropriate automated, 

electronic, mechanical, or other 

technological collection techniques or 

other forms of information technology, 


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