THIS NOTE IS SUBJECT TO THE TERMS OF A SUBORDINATION  AGREEMENT DATED AS OF JUNE
26,  2002 IN  FAVOR  OF  LASALLE  BUSINESS  CREDIT,  INC.,  WHICH  SUBORDINATION
AGREEMENT IS  INCORPORATED  HEREIN BY  REFERENCE.  NOTWITHSTANDING  ANY CONTRARY
STATEMENT CONTAINED HEREIN, NO PAYMENT ON ACCOUNT OF THE PRINCIPAL,  INTEREST OR
OTHER OBLIGATIONS ARISING HEREUNDER,  AND NO RIGHTS GRANTED HEREIN, SHALL BECOME
DUE OR BE  PAID  OR  EXERCIED  EXCEPT  IN  ACCORDANCE  WITH  THE  TERMS  OF SUCH
SUBORDINATION AGREEMENT.

THE SECURITIES  REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED (THE "1933 ACT"),  OR THE  SECURITIES  LAWS OF ANY STATE
AND MAY NOT BE  OFFERED,  SOLD,  PLEDGED OR  OTHERWISE  TRANSFERRED  UNLESS SUCH
OFFER,  SALE,  PLEDGE OR TRANSFER IS REGISTERED UNDER THE 1933 ACT OR APPLICABLE
STATE  SECURITIES  LAWS OR IS EXEMPT FROM SUCH  REGISTRATION.  TRANSFER OF THESE
SECURITIES IS ALSO SUBJECT TO CERTAIN RESTRICTIONS UNDER THE SECURITIES PURCHASE
AGREEMENT DATED JUNE 26, 2002 BETWEEN THE COMPANY AND EUREKA I, L.P.

                        Medical Technology Systems, Inc.

                          14% SENIOR SUBORDINATED NOTE

Note No. 1                                                            $4,000,000


     FOR  VALUE  RECEIVED,   Medical  Technology   Systems,   Inc.,  a  Delaware
corporation  (herein called the "Company"),  hereby promises to pay to Eureka I,
L.P. or its registered assigns (the "Holder"), the principal sum of four million
dollars ($4,000,000),  and to pay interest on the unpaid principal amount hereof
at the rate of fourteen  percent  (14%) per annum,  calculated on the basis of a
360-day year and the actual number of days elapsed,  until the principal  hereof
is paid.  The principal of and interest on this Note shall be paid at such times
as are specified herein. Upon surrender hereof,  payment of the principal of and
interest on this Note, including any prepayment fee if applicable,  will be made
by wire transfer of immediately available funds to the bank account specified by
the Holder.

     This Note is issued pursuant to a Securities  Purchase Agreement dated June
26,  2002 (the  "Purchase  Agreement")  among the  Company,  Eureka I,  L.P.,  a
Delaware limited  partnership,  and Eureka I, L.P., as Collateral  Agent, and is
secured by the Security  Documents,  encumbering  property identified therein as
more  particularly  described  in the  Security  Documents.  The term  "Security
Documents"  has the meaning  specified  in the  Purchase  Agreement.  All of the
terms,  conditions  and  provisions  of the Purchase  Agreement and the Security
Documents  (including the definitions set forth therein) are incorporated herein
by  reference  and are hereby made a part  hereof,  and any breach or  violation

<PAGE>
                                       2

thereof  shall  constitute  a breach or  violation  of this  Note.  This Note is
subject to the terms of a Subordination  Agreement referred to herein. This Note
is subject to the following additional provisions:

     1. Repayment. The principal of this Note shall be paid on June 26, 2007.

     2.  Mandatory and Optional  Prepayment.  The rights and  obligations of the
Company to prepay this Note are set forth in the Purchase Agreement.

     3. Interest. Interest at the rate stated above shall be payable on the last
day of each calendar  month,  beginning  with the first such date to occur after
the date of this Note.

     4.  Indemnification.  The Company and its subsidiaries shall indemnify,  to
the fullest  extent  permitted  by law, the Holder  against all losses,  claims,
damages,  liabilities and expenses (including reasonable attorneys' fees) caused
by, resulting from, arising out of or related to (a) any amendments,  waivers or
consents pursuant to the provisions hereof, (b) the enforcement of this Note, or
the  collection  of amounts due  hereunder or the proof or  allowability  of any
claim arising under this Note, whether in bankruptcy or receivership proceedings
or otherwise,  and (c) in any workout,  restructuring  or in connection with the
protection,  preservation, exercise or enforcement of any of the terms hereof or
of any rights  hereunder or in connection  with any  foreclosure,  collection or
bankruptcy proceedings.

     5.  Subordination.  The  indebtedness  evidenced  by this Note is expressly
subordinated  and junior in right of payment to the prior payment in full of all
Senior Debt (as defined  below),  to the extent and in the manner  provided in a
Subordination   Agreement  dated  as  of  June  26,  2002  (the   "Subordination
Agreement"), among the Company, MTS Packaging Systems, Inc., Eureka I, L.P., and
LaSalle Business Credit,  Inc., and the Holder, by accepting the same, agrees to
and shall be bound by such subordination and by the Subordination Agreement. The
term "Senior Debt" has the meaning specified in the Subordination Agreement.

     6. Amendment and Waiver.  The rights and obligations of the Company and the
rights of the Holder of the Note may be amended or  modified  as provided in the
Purchase Agreement. Defaults and their consequences may be waived as provided in
the  Purchase  Agreement.  Any such consent or waiver  shall be  conclusive  and
binding  upon such  Holder and upon all  future  Holders of this Note and of any
Note issued upon the  registration of transfer hereof or in exchange  herefor or
in lieu  hereof,  whether or not notation of such consent or waiver is made upon
this Note.

     7.  Transfer.  Subject to  certain  limitations  set forth in the  Purchase
Agreement,  the transfer of this Note may be transferred at the principal office
of the Company by surrender thereof for cancellation, endorsed or accompanied by
a written instrument of transfer, duly executed by the registered holder thereof
or its attorney  duly  authorized  in writing,  and  thereupon the Company shall
issue and deliver, in the name of the transferee or transferees, a new note, for
a like aggregate  principal  amount,  dated as of the date to which interest has
been paid on the Note so transferred.

     8.  Exchange.  Subject to  certain  limitations  set forth in the  Purchase
Agreement,  this Note is exchangeable at any time upon the request of the Holder
and upon surrender of this Note for such purpose at the principal offices of the

<PAGE>
                                       3

Company,  the Company will execute and register in the Holder's name in exchange
therefor new notes, in such denomination or denominations (in minimum amounts of
$100,000  and  in  multiples  of  $10,000)  as may be  requested,  an  aggregate
principal  amount  equal  to the  unpaid  principal  amount  of  this  Note  and
substantially in the form thereof,  with appropriate  insertions and variations,
and dated,  and bearing  interest from, the date to which interest has been paid
on this Note  unless no interest  has been paid on this Note,  in which case the
new notes shall be dated the date of this Note.

     9. Default Rate. Upon the occurrence and during the continuance of an Event
of Default (as defined in Section 8.5 of the Purchase Agreement), including, but
not limited to, after maturity or after  judgment,  the Company hereby agrees to
pay to the Holder interest on the outstanding principal balance of the Note and,
to the extent  permitted by law, overdue interest thereon at the rate of 16% per
annum.

     10. Certain  Waivers.  The Company hereby waives  presentment  for payment,
protest and demand, and notice of protest, demand and/or dishonor and nonpayment
of this Note,  notice of any  default  under this Note,  except as  specifically
provided herein, and all other notices or demands otherwise required by law that
the undersigned may lawfully waive. The Company expressly agrees that this Note,
or any payment hereunder,  may be extended from time to time, without in any way
affecting the liability of the Company.

     11. Governing Law;  Jurisdiction;  Waiver of Jury Trial. This Note shall be
governed by and construed in  accordance  with the laws of the  Commonwealth  of
Pennsylvania,  without  regard to conflict  of laws.  The Company and the Holder
hereby  agree  that any  action or  proceeding  arising  out of this Note may be
commenced in state or federal court within the Commonwealth of Pennsylvania. The
Company  and the Holder  waive  personal  service  of  process  and agree that a
summons and complaint commencing an action or proceeding in any such court shall
be  properly  served  and  shall  confer  personal  jurisdiction  if  served  by
registered or certified mail in accordance with the notice  provisions set forth
herein.  The Company and the Holder  hereby  waive any and all right to trial by
jury in any legal proceeding arising out of or relating to this Note.

     12.  Severability.  In the  event  that for any  reason  one or more of the
provisions of this Note or their application to any person or circumstance shall
be held to be invalid, illegal or unenforceable in any respect or to any extent,
such provisions shall  nevertheless  remain valid,  legal and enforceable in all
such other respects and to such extent as may be permissible.  In addition,  any
such  invalidity,  illegality  or  unenforceability  shall not  affect any other
provisions  of this Note,  but this Note shall be construed as if such  invalid,
illegal or unenforceable provision had never been contained herein.

     13.  Notice.  All  notices,  requests,  consents  and other  communications
hereunder  to any party  shall be  deemed to be  sufficient  if  contained  in a
written  instrument  delivered  in  person or duly  sent by  overnight  courier,
facsimile   transmission  or  registered  or  certified  mail,   return  receipt
requested,  postage  prepaid,  addressed  to such party at the address set forth
below or such other  address as may  hereafter be  designated  in writing by the
addressee to the other parties:

<PAGE>
                                       4

          Company:           Medical Technology Systems, Inc.
                             12920 Automobile Boulevard
                             Clearwater, FL  33729
                             Attention:  Todd E. Siegal, President
                                         and Chief Executive Officer
                             Fax:  727-540-0547



<PAGE>
                                       5

          With copies to:    Kilpatrick Stockton LLP
                             301 S. College Street, Suite 3500
                             Charlotte, NC  28202-6001
                             Attention:  Francis C. Pray, Jr., Esq.
                             Fax:  704-371-8306

           Holder:           At the address specified in the Purchase Agreement,
                             or otherwise in writing by the Holder

All such notices and communications shall be deemed to have been received in the
case of (a) facsimile transmission,  on the date sent, (b) personal delivery, on
the date of such  delivery,  (c) overnight  courier,  on the first  business day
following  delivery to such courier and (d) mailing,  on the fifth day after the
posting thereof.

     Prior to due  presentment of this Note for  registration  of transfer,  the
Company  and any agent of the  Company  may treat the  Person in whose name this
Note is  registered  as the owner hereof for all  purposes,  whether or not this
Note be overdue, and neither the Company nor any such agent shall be affected by
notice to the contrary.

<PAGE>
                                       S-1

     IN WITNESS WHEREOF, the Company has caused this Note to be duly executed.

                                     MEDICAL TECHNOLOGY SYSTEMS, INC.

                                     By:  /s/ Todd E. Siegel
                                          __________________________________

                                          Name:  Todd E. Siegel
                                          Title:  President, CEO

Attest:_______________________
       Secretary

Dated: June 26, 2002