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ARS Home Pacific West Area Davis, California Western Human Nutrition Research Center Obesity and Metabolism Research People





Liping  Huang    Research Geneticist **RESEARCH SCIENTIST**
430 West Health Sciences Drive
University of California, Davis
Davis, CA 95616
Phone:(530) 752-5756
/ARSUserFiles/2635/Huang, Liping_001.jpg **HUANG LAB**
 Biography
                              Dr. Liping Huang joined the Western Human Nutrition Research Center in February, 2000. Before joining WHNRC, Dr. Huang worked at the Howard Hughes Medical Institute (HHMI), University of California San Francisco (UCSF) as a post-doctoral associate. Dr. Huang obtained a M.D. degree in Medicine and Public Health at Shanghai Medical University (now Fudan University Shanghai Medical College) in China in 1983 and a Ph.D. degree in molecular biology and virology at University of Iowa College of Medicine in 1995. Dr. Huang has primarily focused on mammalian zinc transporter proteins and their roles in maintaining body zinc homeostasis, regulating body adiposity, insulin metabolism in pancreatic beta-cells, and insulin resistance in muscle and fat.
 Publications(Clicking on the reprint iconReprint Icon  will take you to the publication reprint.)Submission of genetic variant information of the human ZNT7 gene and updating the ClinVar database-(Database / Dataset) Huang, L., Ziegler, A. 2023. Submission of genetic variant information of the human ZNT7 gene and updating the ClinVar database. Clin Var. VCV001711192.3. https://www.ncbi.nlm.nih.gov/clinvar/variation/1711192/?oq=SCV002578244&m=NM_133496.5(SLC30A7):c.21dup%20(p.Asp8fs)Submission of information on a newly discovered genetic genetic disease, namely Zieglar-Huang Syndrome, to the OMIM database-(Database / Dataset) Huang, L., Ziegler, A. 2023. Submission of information on a newly discovered genetic genetic disease, namely Zieglar-Huang Syndrome, to the OMIM database. An Online Catalog of Human Genes and Genetic Disorders (OMIM). 620501. https://www.omim.org/entry/620501?search=slc30a7&highlight=slc30a7.Effects of a genetic variant rs13266634 in the zinc transporter 8 gene (SLC30A8) on insulin and lipid levels before and after a high-fat mixed macronutrient tolerance test in U.S. adults-(Peer Reviewed Journal) Yang, Z., Wang, Y.E., Kirschke-Schneide, C.P., Stephensen, C.B., Newman, J.W., Keim, N.L., Cai, Y., Huang, L. 2023. Effects of a genetic variant rs13266634 in the zinc transporter 8 gene (SLC30A8) on insulin and lipid levels before and after a high-fat mixed macronutrient tolerance test in U.S. adults. Journal of Trace Elements in Medicine and Biology. 77. Article 127142. https://doi.org/10.1016/j.jtemb.2023.127142.Identification of novel compound heterozygous variants in the SLC30A7 (ZNT7) gene in two French brothers with stunted growth, testicular hypoplasia and bone marrow failure-(Peer Reviewed Journal) Huang, L., Yang, Z., Kirschke-Schneide, C.P., Prouteau, C., Copin, M., Bonneau, D., Pellier, I., Coutant, R., Miot, C., Ziegler, A. 2023. Identification of novel compound heterozygous variants in the SLC30A7 (ZNT7) gene in two French brothers with stunted growth, testicular hypoplasia and bone marrow failure. Human Molecular Genetics. 32(12):2016-2031. https://doi.org/10.1093/hmg/ddad033.Trimethylamine N-Oxide response to a mixed macronutrient tolerance test in a cohort of United States adults-(Peer Reviewed Journal) James, K.L., Gertz, E.R., Kirschke-Schneide, C.P., Allayee, H., Huang, L., Kable, M.E., Newman, J.W., Stephensen, C.B., Bennett, B.J. 2023. Trimethylamine N-Oxide response to a mixed macronutrient tolerance test in a cohort of United States adults. International Journal of Molecular Sciences. 24(3). Article 2074. https://doi.org/10.3390/ijms24032074.SNPs in apolipoproteins contribute to sex-dependent differences in blood lipids before and after a high-fat dietary challenge in healthy U.S. adults-(Peer Reviewed Journal) Wang, Y.E., Kirschke-Schneide, C.P., Woodhouse, L.R., Bonnel, E.L., Stephensen, C.B., Bennett, B.J., Newman, J.W., Keim, N.L., Huang, L. 2022. SNPs in apolipoproteins contribute to sex-dependent differences in blood lipids before and after a high-fat dietary challenge in healthy U.S. adults. Biomed Central (BMC) Nutrition. 8. Article 95. https://doi.org/10.1186/s40795-022-00592-x.The Znt7-null mutation has sex dependent effects on the gut microbiota and goblet cell population in the mouse colon-(Peer Reviewed Journal) Kable, M.E., Riazati, N., Kirschke, C.P., Zhao, J., Tepaamorndech, S., Huang, L. 2020. The Znt7-null mutation has sex dependent effects on the gut microbiota and goblet cell population in the mouse colon. PLoS ONE. 15(9). Article e0239681. https://doi.org/10.1371/journal.pone.0239681.Association of estimated daily lactose consumption, lactase persistence genotype (rs4988235), and gut microbiota in healthy U.S. adults-(Abstract Only) Kable, M.E., Chin, E.L., Huang, L., Stephensen, C.B., Lemay, D.G. 2020. Association of estimated daily lactose consumption, lactase persistence genotype (rs4988235), and gut microbiota in healthy U.S. adults. Current Developments in Nutrition. 4/2/1566. https://doi.org/10.1093/cdn/nzaa062_023.Estimated daily Lactose consumption in healthy U.S. adults in relation to lactase persistence genotype (rs4988235)-(Abstract Only)Association of lactase persistence genotypes (rs4988235) and ethnicity with dairy intake in a healthy U.S. population-(Peer Reviewed Journal) Chin, E.L., Huang, L., Bouzid, Y.Y., Kirschke, C.P., Durbin-Johnson, B., Baldiviez, L.M., Bonnel, E.L., Keim, N.L., Korf, I., Stephensen, C.B., Lemay, D.G. 2019. Association of lactase persistence genotypes (rs4988235) and ethnicity with dairy intake in a healthy U.S. population. Nutrients. 11(8):1860. https://doi.org/10.3390/nu11081860.Temporal changes in postprandial blood transcriptomes reveal subject-specific pattern of expression of innate immunity genes after a high-fat meal-(Peer Reviewed Journal) Lemay, D.G., Huang, S., Huang, L., Alkan, Z., Kirschke, C.P., Burnett, D.J., Wang, Y., Hwang, D.H. 2019. Temporal changes in postprandial blood transcriptomes reveal subject-specific pattern of expression of innate immunity genes after a high-fat meal. Journal of Nutritional Biochemistry. 72:108209. https://doi.org/10.1016/j.jnutbio.2019.06.007.Subcongenic analysis of a quantitative trait locus affecting body weight and glucose metabolism in zinc transporter 7 (znt7)-knockout mice-(Peer Reviewed Journal) Huang, L., Tepaamorndech, S., Kirschke, C.P., Cai, Y., Zhao, J., Cao, X., Rao, A. 2019. Subcongenic analysis of a quantitative trait locus affecting body weight and glucose metabolism in zinc transporter 7 (znt7)-knockout mice. BioMed Central (BMC) Genetics. 20:19. https://doi.org/10.1186/s12863-019-0715-2.SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the ß-cells-(Peer Reviewed Journal) Cai, Y., Kirschke, C.P., Huang, L. 2018. SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the ß-cells. Journal of Molecular Histology. 49(2):133-145. https://doi.org/10.1007/s10735-017-9753-0.Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults-(Peer Reviewed Journal) Baldiviez, L.M., Keim, N.L., Laugero, K.D., Hwang, D.H., Huang, L., Woodhouse, L.R., Burnett, D.J., Zerofsky, M., Bonnel, E., Allen, L.H., Newman, J.W., Stephensen, C.B. 2017. Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults. Biomed Central (BMC) Nutrition. 3(79):1-13. https://doi.org/10.1186/s40795-017-0197-4.Aberrant fatty acid metabolism in the skeletal muscle contributes to insulin resistance in zinc transporter 7 (Znt7) knockout mice-(Peer Reviewed Journal) Huang, L., Tepaamorndech, S., Kirschke, C.P., Newman, J.W., Keyes, W.R., Pedersen, T.L. 2018. Aberrant fatty acid metabolism in the skeletal muscle contributes to insulin resistance in zinc transporter 7 (Znt7) knockout mice. Journal of Biological Chemistry. 293(20):7549-7563. doi:10.1074/jbc.M117.817692.ZNT7 binds to CD40 and influences CD154-triggered p38 MAPK activity in B lymphocytes-a possible regulatory mechanism for zinc in immune function-(Peer Reviewed Journal) Tepaamorndech, S., Oort, P.J., Kirschke, C.P., Yimeng, C., Huang, L. 2017. ZNT7 binds to CD40 and influences CD154-triggered p38 MAPK activity in B lymphocytes-a possible regulatory mechanism for zinc in immune function. FEBS Open Bio. 7(5):675–690. doi: 10.1002/2211-5463.12211.Down-regulation of zinc transporter 8 (SLC30A8) in pancreatic beta-cells promotes cell survival-(Peer Reviewed Journal) Huang, L., Kirschke, C.P. 2016. Down-regulation of zinc transporter 8 (SLC30A8) in pancreatic beta-cells promotes cell survival. Austin Journal of Endocrinology and Diabetes. 3:1037.Down-regulation of zinc transporter 8 (SLC30A8) in pancreatic beta-cells promotes cell survival.-(Peer Reviewed Journal) Huang, L., Kirschke, C.P. 2016. Down-regulation of zinc transporter 8 (SLC30A8) in pancreatic beta-cells promotes cell survival.. Austin Journal of Endocrinology and Diabetes. 3(1):1-8.Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activity and glucose uptake-(Peer Reviewed Journal) Tepaamorndech, S., Kirschke, C.P., Pedersen, T.L., Keyes, W.R., Newman, J.W., Huang, L. 2015. Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activity and glucose uptake. FEBS Journal. 283(2):378-394. doi: 10.1111/febs.13582.Linking cellular zinc status to body weight and fat mass: mapping quantitative trait loci in Znt7 knockout mice-(Peer Reviewed Journal)Zinc-(Peer Reviewed Journal) Huang, L., Drake, V.J., Ho, E. 2015. Zinc. Advances in Nutrition. 6:224-226.Zinc and its transporters, pancreatic beta cells, and insulin metabolism-(Book / Chapter) Huang, L. 2014. Zinc and its transporters, pancreatic beta cells, and insulin metabolism. In: Litwack, G. editor. Vitamins and Hormones. Atlanta, GA: Elsevier. p.365-390.The SLC30 family of zinc transporters – a review of current understanding of their biological and pathophysiological roles-(Peer Reviewed Journal) Huang, L., Tepaamorndech, S. 2013. The SLC30 family of zinc transporters – a review of current understanding of their biological and pathophysiological roles. European Journal of Applied Physiology. 34(2-3):548-560.Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice and selectively lowers plasma C-reactive protein in lean mice-(Peer Reviewed Journal) Parelman, M.A., Storms, D.H., Kirschke, C.P., Huang, L., Zunino, S.J. 2012. Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice and selectively lowers plasma C-reactive protein in lean mice. British Journal of Nutrition. 1-11. DOI: 10.1017/S0007114512000037.Diet-influenced chromatin modification and expression of chemopreventive genes by the soy peptide, lunasin-(Book / Chapter) Galvez, A., Huang, L., Magbanua, M.M., Dawson, K., Nandi, S., Rodriguez, R.L. 2011. Diet-influenced chromatin modification and expression of chemopreventive genes by the soy peptide, lunasin. In: Bidlack, W.R., Rodriguez, R.L., editors. Nutritional Genomics: The Impact of Dietary Regulation of Gene Function on Human Disease. Taylor and Francis Group. 25-40.A null-mutation in the Znt7 gene accelerates prostate tumor formation in a transgenic adenocarcinoma mouse prostate model-(Peer Reviewed Journal) Tepaamorndech, S., Huang, L., Kirschke, C.P. 2011. A null-mutation in the Znt7 gene accelerates prostate tumor formation in a transgenic adenocarcinoma mouse prostate model. Cancer Letters. 308 (2011) 33-42.Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription-(Peer Reviewed Journal) Huang, L., Mi, Y., Kirschke, C.P. 2010. Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription. Experimental Cell Research. 2010 Volume 316, Issue 16 2630-2643Expression of ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation-(Peer Reviewed Journal) Kirschke, C.P., Huang, L. 2008. Expression of ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation. Journal of Histochemistry and Cytochemistry (2008) 39:359-370.Expression of zinc transporter ZnT7 in mouse superior cervical ganglion-(Peer Reviewed Journal) Gao, H., Xu, H., Wang, X., Dahlstrom, A., Huang, L., Wang, Z. 2008.  Expression of zinc transporter ZnT7 in mouse superior cervical ganglion. Autonomic Neuroscience: Basic & Clinical, 140 (2008) 59-65.The cellular and subcellular localization of zinc transporter 7 in the mouse spinal cord-(Peer Reviewed Journal) Chi, Z., Ren, H., Wang, X., Rong, M., Huang, L., Wang, Z. 2008. The cellular and subcellular localization of zinc transporter 7 in the mouse spinal cord. Histology and Histopathology Cellular and Molecular Biology, Vol.23:781-787Abundant Expression of Zinc Transporters in the Amyloid Plaques of  Alzheimer’s Disease Brain-(Peer Reviewed Journal) Zhang, L., Wang, X., Stoltenberg, M., Danscher, G., Huang, L., Wang, Z. 2008. Abundant Expression of Zinc Transporters in the Amyloid Plaques of  Alzheimer’s Disease Brain. Elsevier. Brain Research Bulletin 77 (2008) 55-60.ALTERED EXPRESSION AND DISTRIBUTION OF ZINC TRANSPORTERS IN APP/PS1 TRANSGENIC MOUSE BRAIN-(Peer Reviewed Journal) Zhang, L., Wang, X., Zheng, Z., Ren, H., Stoltenberg, M., Danscher, G., Huang, L., Rong, M., Wang, Z. 2008. Altered expression and distribution of zinc transporters in app/ps1 transgenic mouse brain. Elsevier, Journal Neurobiology of Aging, Doi:10,1016:1-14, 2008.Znt7 (Slc30a7)-DEFICIENT MICE DISPLAY REDUCED BODY ZINC STATUS AND BODY FAT ACCUMULATION-(Peer Reviewed Journal) Huang, L., Yu, Y., Kirschke, C.P., Gertz, E.R., Kent K.C., L. 2008.   Znt7 (Slc30a7)-Deficient Mice Display Rreduced Body ZincC Status and Body Fat Accumulation. Journal of Biological Chemistry. 282,51:37053-37063, 2007.Imunoreactivity of zinc transporter 7 (ZNT7) in mouse dorsal root ganglia-(Peer Reviewed Journal) Zhang, L., Chi, Z., Ren, H., Rong, M., Dahlstrom, A., Huang, L., Wang, Z. 2007. Imunoreactivity of zinc transporter 7 (ZNT7) in mouse dorsal root ganglia. Elsevier. Brain Research Bulletin 74 (2007) 278-283.A DI-LEUCINE SORTING SIGNAL IN ZIP1 (SLC39A1) MEDIATES ENDOCYTOSIS OF THE PROTEIN-(Peer Reviewed Journal) Huang, L., Kirschke, C.P. A di-leucine sorting signal in zip1 (slc39a1) mediates endocytosis of the protein. FEDERATION OF EUROPEAN BIOCHEMICAL SOCIETY, 274: 3986-3997, 2007.Localization of ZnT7 and zinc ions in mouse retina-Immunohistochemistry and selenium autometallography-(Other) Wang, X., Wang, Z., Gao, H., Danscher, G., Huang, L. Localization of ZnT7 and zinc ions in mouse retina-Immunohistochemistry and selenium autometallography. Brain Research Bulletin, 2006.71:91-96IMMUNOHISTOCHEMICAL ANALYSIS OF ZNT1, 4, 5, 6, AND 7 IN THE MOUSE GASTROINTESTINAL TRACT-(Peer Reviewed Journal) Yu, Y.Y., Kirschke, C.P., Huang, L. 2006. IMMUNOHISTOCHEMICAL ANALYSIS OF ZNT1, 4, 5, 6, AND 7 IN THE MOUSE GASTROINTESTINAL TRACT. Journal of Histochemistry and Cytochemistry.  Vol. 55(3):223-234, 2006.Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells-(Peer Reviewed Journal) Chi, Z., Wang, X., Wang, Z., Gao, H., Dahlstrom, A., Huang, L. 2006. Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells. NeuroReport. 2006. Vol.17:1807-1811.DECREASED INTRACELLULAR ZINC IN HUMAN TUMORIGENIC PROSTATE EPITHELIAL CELLS: A POSSIBLE ROLE IN PROSTATE CANCER PROGRESSION-(Peer Reviewed Journal) Huang, L., Kirschke, C.P., Zhang, Y. Decreased intracellular zinc in human tumorigenic prostate epithelial cells: a possible role in prostate cancer progression. Cancer Cell International 2006, 6:10, 2006.NUTRIENT-GENE INTERACTIONS INVOLVING SOY PEPTIDE AND CHEMOPREVENTIVE GENES IN PROSTATE EPITHELIAL CELLS-(Peer Reviewed Journal) Magvanua, M.J., Dawson, K., Huang, L., Malyj, W., Gregg, J., Galvez, A.F., Rodriguez, R.L. 2006. NUTRIENT-GENE INTERACTIONS INVOLVING SOY PEPTIDE AND CHEMOPREVENTIVE GENES IN PROSTATE EPITHELIAL CELLS. John Wiley & Sons, Inc. Chapter 11:255-276.ZIP7 GENE (SLC39A7) ENCODES A ZINC TRANSPORTER INVOLVED IN ZINC HOMEOSTASIS OF THE GOLGI APPARATUS-(Peer Reviewed Journal) Huang, L., Kirschke, C.P., Zhang, Y., Yu, Y. 2005. ZIP7 GENE (SLC39A7) ENCODES A ZINC TRANSPORTER INVOLVED IN ZINC HOMEOSTASIS OF THE GOLGI APPARATUS. Journal of Biological Chemistry 280(15):15456-15463, 2005.ABUNDANT EXPRESSION OF ZINC TRANSPORTERS IN BERGMAN GLIA OF MOUSE CEREBELLUM-(Peer Reviewed Journal) Wang, Z., Stoltenberg, M., Huang, L., Danscher, G., Dahlstrom, A., Shi, Y., Li, J. 2004. ABUNDANT EXPRESSION OF ZINC TRANSPORTERS IN BERGMAN GLIA OF MOUSE CEREBELLUM. Elsevier.  Bulletin 64:441-44, 2004.INVESTIGATION OF LYMPHOCYTE GENE EXPRESSION FOR USE AS BIOMARKERS FOR ZINC STATUS IN HUMANS-(Peer Reviewed Journal) Andree, K.B., Kim, J., Kirschke, C.P., Gregg, J.P., Paik, H., Joung, H., Woodhouse, L.R., King, J., Huang, L. 2004. Investigation of lymphocyte gene expression for use as biomarkers for zinc status in humans. Journal of Nutrition.  Journal of Nutrition. 134:1716-1723, 2004.DYNAMIC ZINC POOLS IN MOUSE CHOROID PLEXUS-(Peer Reviewed Journal) Wang, Z., Stoltenberg, M., Jo, S.M., Huang, L., Larsen, A., Dahlstrom, A., Danscher, G. 2004. Dynamic zinc pools in mouse choroid plexus. NeuroReport, 15:1801-1804, Lippincott, Williams & Wilkins.ZNT7, A NOVEL MAMMALIAN ZINC TRANSPORTER, ACCUMULATES ZINC IN THE GOLGI APPARATUS-(Peer Reviewed Journal) Kirschke, C.P., Huang, L. 2004. Znt7, a novel mammalian zinc transporter, accumulates zinc in the golgi apparatus. Journal of Biological Chemistry. 278:4096-103, 2004.EFFLUX AND COMPARTMENTALIZATION OF ZINC BY MEMBERS OF THE SLC30 FAMILY OF SOLUTE CARRIERS-(Peer Reviewed Journal) Palmiter, R.D., Huang, L. 2004. Efflux and compartmentalization of zinc by members of the slc30 family of solute carriers. Journal of Physiology (2004) 447:744-51.  ProjectsMolecular Determinants of Energy Metabolism Regulation and Gut Function in Response to Zinc DeficiencyIn-House Appropriated (D)Accession Number:445316 ARS News ArticlesitemTesting Your Zinc: Is the ZIP1 Gene the Best Choice?
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7/23/2020

    

    
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