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 Grand Forks Human Nutrition Research Center: Grand Forks, ND
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ARS Home Plains Area Grand Forks, North Dakota Grand Forks Human Nutrition Research Center People





- Scientists
- Derek Bussan
- Jay Cao
- Shanon Casperson
- Julie Hess
- Forrest Nielsen
- James Roemmich
- Lin Yan
- Huawei Zeng

Huawei  Zeng    Research Molecular Biologist /ARSUserFiles/12326/images/Hauwei-Zeng-2022.jpg
 Huawei Zeng, Ph.D.  Contact information (701) 795-8465huawei.zeng@usda.gov
 **Biography** Dr. Zeng was born and grew up in Xiamen, China. He obtained B.S. and M.S. degrees in Biology from Xiamen University. He attended the University of Wyoming, where he earned a Doctor of Philosophy degree in Molecular Biology in 1996. After graduation, Dr. Zeng spent three and half years as a postdoctoral researcher at the National Institutes of Health (Bethesda, MD) investigating steroid hormone-induced gene expression. Dr. Zeng joined the scientific staff of the USDA-ARS Grand Forks Human Nutrition Research Center (GFHNRC) as a Research Molecular Biologist in November1999.
 **Research Interests** Obesity related colon cancer is a significant global health concern and the impact of specific dietary components on colon cancer risk has been well recognized. Dr. Zeng's main area of research is to determine the molecular mechanisms of cancer-preventive nutrients in foods. This focus presently centers on dietary fiber / diet timing and gut microbiome, and the development of new molecular biomarkers for obesity related colon cancer prevention. Currently, Dr. Zeng is studying the effects of secondary bile acids and short chain fatty acids in the colon: a focus on colonic microbiome, cell proliferation, inflammation, and cancer. Dr. Zeng is also investigating the impact of human genetic variation on optimal nutritional intake. Single nucleotide polymorphisms (SNPs) are a primary component of human genetic variation. To determine the diet that best fits certain SNPs, He examines the effects of hemochromatosis, selenoproteins and vitamin D receptor genotypes on the absorption and utilization of iron, selenium, calcium and other nutrients.
 **Research Accomplishments** Molecular Nutrition & Cancer Biology:  Demonstrated for the first time that through the activation of certain pro-apoptotic genes linked to p53, NFkB, and stress signal pathways, mice fed a selenium-enriched broccoli had stronger apoptotic ability in response to spontaneous colon tumor development caused by a genetic defect. This contributes to our incomplete knowledge about how nutrients affect gene expression and reduce obesity-related cancer risk. The findings are important because sensitive gene markers are needed to evaluate the anticancer effect of functional foods.
Demonstrated that both methylselenol and butyrate inhibit tumor cell migration and invasion, and that they exerted secondary cancer prevention through the inhibition of pro-MMP-2 activation. These findings provide the molecular evidence that secondary cancer prevention can be achieved by the high dietary intakes of selenium-enriched or high fiber foods. In addition, these data lay the groundwork for screening sensitive gene markers that are needed to evaluate the anticancer foods such as selenium-enriched or high fiber foods.
Determined the gut microbiome signature related to fatty liver, colonic inflammation in the context of obesity; and demonstrated that consumption of a high-fat diet increased colonic and liver inflammation which are associated with an increase of Lachnospiraceae, Streptococcaceae and Lactobacillus acidophilus bacteria. This work was the first to identify the connection of these three bacterial taxa and the colonic / liver inflammation. Because Lachnospiraceae, Streptococcaceae and Lactobacillus acidophilus are associated with colonic/liver inflammation, these findings provide the opportunity for the development of potential non-invasive markers for assessing the health status of the colon and liver.
Identified a potential pathway linking dietary fiber to cancer prevention; demonstrated that butyrate inhibits deoxycholic-acid resistant cell proliferation at the cellular and molecular level. These data provide a proof of concept that butyrate can protect against colon carcinogenesis through a specific targeting of DCA-resistant colonic cells. The finding provides new avenues to study dietary fiber and colon cancer prevention at the cellular and molecular levels.
 Curriculum Vitae (PDF)
 ProjectsModification of Diurnal Patterns to Promote Health in Models for Human Metabolic DysfunctionIn-House Appropriated (D)Accession Number:436804Clinical ResearchNon-Assistance Cooperative Agreement (S)Accession Number:438433
 Publications(Clicking on the reprint iconReprint Icon  will take you to the publication reprint.)Efficacy of butyrate to inhibit colonic cancer cell growth is cell type-specific and apoptosis-dependent-(Peer Reviewed Journal) Oncel, S., Safratowich, B.D., Lindlauf, J., Liu, Z., Palmer, D., Briske Anderson, M.J., Zeng, H. 2024. Efficacy of butyrate to inhibit colonic cancer cell growth is cell type-specific and apoptosis-dependent. Nutrients. 16(4). Article 529. https://doi.org/10.3390/nu16040529.Tumor necrosis factor-a knockout mitigates intestinal inflammation and tumorigenesis in obese Apc1638N mice-(Peer Reviewed Journal) Li, J., Tang, Y., Lin, T., Zeng, H., Mason, J.B., Lui, Z. 2023. Tumor necrosis factor-a knockout mitigates intestinal inflammation and tumorigenesis in obese Apc1638N mice. Journal of Nutritional Biochemistry. 117. Article 109355. https://doi.org/10.1016/j.jnutbio.2023.109355.Time-restricted feeding modifies the fecal lipidome and the gut microbiota-(Peer Reviewed Journal) Rust, B.M., Picklo, M.J., Yan, L., Mehus, A.A., Zeng, H. 2023. Time-restricted feeding modifies the fecal lipidome and the gut microbiota. Nutrients. 15(7):1-17. https://doi.org/10.3390/nu15071562.Consumption of a high-fat diet alters transcriptional rhythmicity in liver from pube pubertal mice-(Peer Reviewed Journal) Yan, L., Sundaram, S., Rust, B., Daniel, P., Luann, J., Zeng, H. 2023. Consumption of a high-fat diet alters transcriptional rhythmicity in liver from pube pubertal mice. Frontiers in Nutrition. 9. Article 1068350. https://doi.org/10.3389/fnut.2022.1068350.Changes of the fecal metabolome accompany an increase in aberrant crypt foci in the colon of C57BL/6 mice fed a high-fat diet-(Peer Reviewed Journal) Zeng, H., Safratowich, B.D., Cheng, W., Magnuson, A.D., Picklo, M.J. 2022. Changes of the fecal metabolome accompany an increase in aberrant crypt foci in the colon of C57BL/6 mice fed a high-fat diet. Biomedicines. 10(11). Article 2891. https://doi.org/10.3390/biomedicines10112891.Identification of fecal oncogenic signatures in the inflammatory colon of C57BL/6 mice fed a high fat diet-(Peer Reviewed Journal) Zeng, H., Safratowich, B.D., Cheng, W., Bukowski, M.R. 2022. Identification of fecal oncogenic signatures in the inflammatory colon of C57BL/6 mice fed a high fat diet. Journal of Nutritional Biochemistry. 111. https://doi.org/10.1016/j.jnutbio.2022.109188.Selenium status and type 2 diabetes risk-(Peer Reviewed Journal) Huang, Y., Combs, G., Wu, T., Zeng, H., Cheng, W. 2022. Selenium status and type 2 diabetes risk. Archives of Biochemistry and Biophysics. 730. https://doi.org/10.1016/j.abb.2022.109400.Deoxycholic acid modulates cell-junction gene expression and increases intestinal barrier dysfunction in Caco-2 cell monolayers-(Peer Reviewed Journal) Zeng, H., Safratowich, B.D., Cheng, W., Larson, K.J., Briske Anderson, M.J. 2022. Deoxycholic acid modulates cell-junction gene expression and increases intestinal barrier dysfunction in Caco-2 cell monolayers. Molecular Nutrition and Food Research. https://doi.org/10.3390/molecules27030723.Azoxymethane alters the plasma metabolome to a greater extent in mice fed a high fat diet compared to an AIN-93 diet-(Peer Reviewed Journal) Zeng, H., Umar, S., Liu, Z., Bukowski, M.R. 2021. Azoxymethane alters the plasma metabolome to a greater extent in mice fed a high fat diet compared to an AIN-93 diet. International Journal of Molecular Sciences. https://doi.org/10.3390/metabo11070448.Dietary selenium requirement for the prevention of glucose intolerance and insulin resistance in middle-aged mice-(Peer Reviewed Journal) Huang, Y., Zeng, H., Wu, T., Cheng, W. 2021. Dietary selenium requirement for the prevention of glucose intolerance and insulin resistance in middle-aged mice. Journal of Nutrition. 151:1894-1900. https://doi.org/10.1093/jn/nxab053.Adequacy of calcium and vitamin D reduces inflammation, beta-catenin signaling and dysbiotic Parasutterela bacteria in the colon of C57BL/6 mice fed a Western-style diet-(Peer Reviewed Journal) Zeng, H., Safratowich, B.D., Liu, Z., Bukowski, M.R., Ishaq, S. 2021. Adequacy of calcium and vitamin D reduces inflammation, beta-catenin signaling and dysbiotic Parasutterela bacteria in the colon of C57BL/6 mice fed a Western-style diet. Journal of Nutritional Biochemistry. 92. Article 108613. https://doi.org/10.1016/j.jnutbio.2021.108613.Time-restricted feeding mice a high-fat diet induces a unique lipidomic profile-(Peer Reviewed Journal) Mehus, A.A., Rust, B.M., Idso, J.P., Hanson, B.K., Zeng, H., Yan, L., Bukowski, M.R., Picklo, M.J. 2020. Time-restricted feeding mice a high-fat diet induces a unique lipidomic profile. Journal of Nutritional Biochemistry. 88. Article 108531. https://doi.org/10.1016/j.jnutbio.2020.108531.Superior inhibitory efficacy of butyrate over propionate and acetate against human colon cancer cell proliferation via cell cycle arrest and apoptosis-(Peer Reviewed Journal) Zeng, H., Hamlin, S.K., Safratowich, B.D., Cheng, W., Johnson, L.K. 2020. Superior inhibitory efficacy of butyrate over propionate and acetate against human colon cancer cell proliferation via cell cycle arrest and apoptosis. Nutrition Research. 83:63-72. https://doi.org/10.1016/j.nutres.2020.08.009.Butyrate inhibits deoxycholic-acid-resistant colonic cell proliferation via cell cycle arrest and apoptosis-(Peer Reviewed Journal) Zeng, H., Safratowich, B.D., Wang, T.T., Hamlin, S., Johnson, L. 2020. Butyrate inhibits deoxycholic-acid-resistant colonic cell proliferation via cell cycle arrest and apoptosis. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201901014.Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic secondary bile acids and Lactobacillaceae/Lachnospiraceae bacteria in C57BL/6 mice fed a high-fat diet-(Peer Reviewed Journal) Zeng, H., Larson, K.J., Cheng, W., Bukowski, M.R., Safratowich, B.D., Liu, Z., Hakkak, R. 2020. Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic secondary bile acids and lactobacillaceae/lachnospiraceae bacteria in C57BL/6 mice fed a high-fat diet. Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2019.108336.Genetic ablation of tumor necrosis factor-alpha attenuates colonic Wnt-signaling associated with obesity-(Peer Reviewed Journal) Guo, C., Kim, S.J., Frederick, A., Li, J., Jin, Y., Zeng, H., Mason, J.B., Liu, Z. 2019. Genetic ablation of tumor necrosis factor-alpha attenuates colonic Wnt-signaling associated with obesity. Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2019.108302.Dietary saturated fatty acid type impacts obesity-induced metabolic dysfunction and plasma lipidomic signatures in mice-(Peer Reviewed Journal) Zacek, P., Bukowski, M.R., Mehus, A.A., Johnson, L., Zeng, H., Raatz, S.K., Idso, J.P., Picklo, M.J. 2018. Dietary saturated fatty acid type impacts obesity-induced metabolic dysfunction and plasma lipidomic signatures in mice. Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2018.10.005.Secondary bile acids and short chain fatty acids in the colon:  a focus on colonic microbiome, cell proliferation, inflammation and cancer-(Review Article) Zeng, H., Shahid, U., Rust, B., Darina, L., Michael, B. 2019. Secondary bile acids and short chain fatty acids in the colon:  a focus on colonic microbiome, cell proliferation, inflammation and cancer. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20051214.Fecal fermentation products of common bean-derived fiber inhibit C/EBP alpha and PPAR gamma expression and lipid accumulation but stimulate PPAR delta and UCP2 expression in the adipogenesis of 3T3-L1 cells-(Peer Reviewed Journal) Lu, H., Zeng, H., Zhang, L., Porres, J.M., Cheng, W. 2018. Fecal fermentation products of common bean-derived fiber inhibit C/EBP alpha and PPAR gamma expression and lipid accumulation but stimulate PPAR delta and UCP2 expression in the adipogenesis of 3T3-L1 cells. Journal of Nutritional Biochemistry. 60:9-15. https://doi.org/10.1016/j.jnutbio.2018.06.004.Beneficial and paradoxical roles of selenium at nutritional levels of intake in healthspan and longevity-(Review Article) Zhang, L., Zeng, H., Cheng, W. 2018. Beneficial and paradoxical roles of selenium at nutritional levels of intake in healthspan and longevity. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2018.05.067.Aberrant crypt formation accompanies an increase of opportunistic pathogens/bacteria in the inflammatory gut of C57BL/6 mice fed a high-fat diet-(Abstract Only) Zeng, H., Ishaq, S.L., Liu, Z., Keehr, K.A., Bukowski, M.R. 2017. Aberrant crypt formation accompanies an increase of opportunistic pathogens/bacteria in the inflammatory gut of C57BL/6 mice fed a high-fat diet [abstract]. Journal of Federation of American Societies for Experimental Biology. 31:435.5.Coconut oil prevents hepatic steatitis but not adipose inflammation in obese mice-(Abstract Only) Picklo, M.J., Idso, J.P., Zeng, H. 2017. Coconut oil prevents hepatic steatitis but not adipose inflammation in obese mice [abstract]. Journal of Federation of American Societies for Experimental Biology. 31:971.25.Effects of a-high- and low-diadzein diet on liver steatosis and serum adipokines in female obese Zucker rats-(Abstract Only) Bell, A., Korourian, S., Zeng, H., Phelps, J., Crook, T., Gurley, B., Feresin, R.G., Hakka, R. 2017. Effects of a-high- and low-diadzein diet on liver steatosis and serum adipokines in female obese Zucker rats [abstract]. Journal of Federation of American Societies for Experimental Biology. 31:793.1.Colonic aberrant crypt formation accompanies an increase of opportunistic pathogenic bacteria in C57BL/6 mice fed a high-fat diet-(Peer Reviewed Journal) Zeng, H., Ishaq, S.L., Liu, Z., Bukowski, M.R. 2017. Colonic aberrant crypt formation accompanies an increase of opportunistic pathogenic bacteria in C57BL/6 mice fed a high-fat diet. Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2017.11.001.Analyses of selenotranscriptomes and selenium concentrations in response to dietary selenium deficiency and age reveal common and distinct patterns by tissue and sex in telomere-dysfunctional mice-(Peer Reviewed Journal) Cao, L., Zeng, H., Wu, R.T., Wu, T., Cheng, W. 2017. Analyses of selenotranscriptomes and selenium concentrations in response to dietary selenium deficiency and age reveal common and distinct patterns by tissue and sex in telomere-dysfunctional mice. Journal of Nutrition. 147(10):1858-1866.A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model-(Peer Reviewed Journal) Bell, A., Korourian, S., Zeng, H., Phelps, J., Hakkak, R. 2017. A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model. Food & Function. 8(3):1293-1298.High fat diet alters gut microbiota and the expression of Paneth cell-antimicrobial peptides preceding changes of circulating inflammatory cytokines-(Peer Reviewed Journal) Guo, Z., Li, J., Tang, T., Zeng, H., Wood, R., Liu, Z. 2017. High fat diet alters gut microbiota and the expression of Paneth cell-antimicrobial peptides preceding changes of circulating inflammatory cytokines. Mediators of Inflammation. doi:10.1155/2017/9474896.Butyrate inhibits cancerous HCT116 cell proliferation but to a lesser extent in noncancerous NCM460 colon cells-(Peer Reviewed Journal) Zeng, H., Taussig, D., Cheng, W., Johnson, L., Hakkak, R. 2017. Butyrate inhibits cancerous HCT116 cell proliferation but to a lesser extent in noncancerous NCM460 colon cells. Nutrients. 9(1):25-38.Opposing impacts on healthspan and longevity by limiting dietary selenium in Telomere Dysfunctional mice-(Peer Reviewed Journal) Wu, R.T., Cao, L., Mattson, E., Witwer, K.W., Cao, J.J., Zeng, H., He, X., Combs, G.F., Cheng, W. 2017. Opposing impacts on healthspan and longevity by limiting dietary selenium in Telomere Dysfunctional mice. Aging Cell. 16(1):125-135.Trifluoroselenomethionine: A new unnatural amino acid-(Peer Reviewed Journal) Block, E., Booker, S., Flores-Penalba, S., George, G., Landgraf, B., Li, F., Lodge, S.N., Pushie, J., Rozovsky, S., Vattekkatte, A., Yaghi, R., Zeng, H. 2016. Trifluoroselenomethionine: A new unnatural amino acid. ChemBioChem. 17(18):1738-1751.Loss of selenium-binding protein 1 decreases sensitivity to clastogens and intracellular selenium content in HeLa cells-(Peer Reviewed Journal) Zhai, C., Wu, R., Zeng, H., Cheng, W. 2016. Loss of selenium-binding protein 1 decreases sensitivity to clastogens and intracellular selenium content in HeLa cells. PLoS One. 11(7):e0158650. doi:10.1371/journal.pone.01586.Colonic inflammation and enhanced-beta-catenin signaling accompany an increase of the Lachnospiraceae/Streptococcaceae in the hind gut of high-fat diet-fed mice-(Peer Reviewed Journal) Zeng, H., Ishaq, S.L., Zhao, F., Wright, A.G. 2016. Colonic inflammation and enhanced-beta-catenin signaling accompany an increase of the Lachnospiraceae/Streptococcaceae in the hind gut of high-fat diet-fed mice. Journal of Nutritional Biochemistry. (35)30-36.Novel correlations between microbial taxa and amino acid metabolites in mouse cecal contents-(Abstract Only) Taussig, D.P., Jackson, M., Zeng, H., Combs, Jr., G.F. 2016. Novel correlations between microbial taxa and amino acid metabolites in mouse cecal contents [abstract]. Keystone Symposia: Microbiota, Metabollic Disorders and Beyond, April 17-21, 2016, Newport, Rhode Island. p 75.Butyrate plays differential roles in cellular signaling in cancerous HCT116 and noncancerous NCM460 colon cells-(Abstract Only) Zeng, H., Taussig, D.P., Cheng, W., Hakkak, R. 2016. Butyrate plays differential roles in cellular signaling in cancerous HCT116 and noncancerous NCM460 colon cells [abstract]. Federation of American Societies for Experimental Biology Conference, April 1-6, 2016, San Diego, California. 30:688.9.Colonic inflammation and enhanced-beta-catenin signaling accompany an increase of the Lachnospiraceae/Streptococcaceae in the hind gut of high-fat diet-fed mice-(Abstract Only) Zeng, H., Ishaq, S.L., Zhao, F., Wright, A.G. 2016. Colonic inflammation and enhanced-beta-catenin signaling accompany an increase of the Lachnospiraceae/Streptococcaceae in the hind gut of high-fat diet-fed mice [abstract]. Federation of American Societies for Experimental Biology Conference, April 1-6, 2016, San Diego, California. 30:1166.4.Climatic thresholds for concentrations of minerals and heavy metals in Argentinean soybeans-(Peer Reviewed Journal) Marioli Nobile, C.G., Balzarini, M., Aguate, F.M., Grosso, N., Soldini, D.O., Zeng, H., Cheng, W., Martinez, M. 2016. Climatic thresholds for concentrations of minerals and heavy metals in Argentinean soybeans. Agronomy Journal. 108(2):532-539.Integrating multiple analytical datasets to compare metabolite profiles of mouse colonic-cecal contents and feces-(Peer Reviewed Journal) Zeng, H., Grapov, D., Fahrmann, J., Fiehn, O., Combs, G.F. 2015. Integrating multiple analytical datasets to compare metabolite profiles of mouse colonic-cecal contents and feces. Metabolites. 5:489-501.Short and long-term soy diet vs. casein protects liver steatosis independent of the arginine content-(Peer Reviewed Journal) Hakkak, R., Zeng, H., Korourian, S. 2015. Short and long-term soy diet vs. casein protects liver steatosis independent of the arginine content. British Journal of Nutrition [epub ahead of print]. http://online.liebertpub.com/doi/10.1089/jmf.2015.0002.Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation-(Peer Reviewed Journal) Zeng, H., Claycombe, K.J., Reindl, K.M. 2015. Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation. Journal of Nutritional Biochemistry. 26:1022-1028.The inhibitory efficacy of methylseleninic acid against colon cancer xenografts in C57BL/6 mice-(Peer Reviewed Journal) Zeng, H., Wu, M. 2015. The inhibitory efficacy of methylseleninic acid against colon cancer xenografts in C57BL/6 mice. Nutrition and Cancer. 67(5):831-838.Integrated datasets characterize metabolic interactions between mouse’s colonic mucosa, colonic-cecal contents and feces-(Abstract Only) Zeng, H., Grapov, D., Jackson, M.I., Fahrmann, J., Fiehn, O., Combs, G.F. 2015. Integrated datasets characterize metabolic interactions between mouse’s colonic mucosa, colonic-cecal contents and feces [abstract]. Journal of Federation of American Societies for Experimental Biology. 29:748.7.Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation-(Abstract Only) Zeng, H., Claycombe, K.J., Reindl, K.M. 2015. Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation [abstract]. Journal of Federation of American Societies for Experimental Biology. 29:752.4.Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin-(Peer Reviewed Journal) Tzeng, T.J., Fu, Y., Zeng, H., Cheng, W. 2014. Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin. PLoS One. 9(7):e101664.Methylselenol, a selenium metabolite, inhibits colon cancer cell growth and cancer xenografts in C57BL/6 mice-(Abstract Only) Zeng, H. 2014. Methylselenol, a selenium metabolite, inhibits colon cancer cell growth and cancer xenografts in C57BL/6 mice [abstract]. Federation of American Societies for Experimental Biology Conference. 28(1):374.2.Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention-(Peer Reviewed Journal) Zeng, H., Lazarova, D.L., Bordonaro, M. 2014. Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention. World Journal of Gastrointestinal Oncology. 6(2):41-51.Dietary effects on adipocyte metabolism and epigenetics-(Book / Chapter) Claycombe, K.J., Zeng, H., Combs, G.F. 2015. Dietary effects on adipocyte metabolism and epigenetics. In: Ho, E. Domann, F. Nutrition and Epigenetics.  Boca Raton, FL. CRC Press. p. 323-335.Decreased levels of miR-224 and the passenger strand of miR-221
increase MBD2, suppressing maspin and promoting colorectal tumor
growth and metastasis in mice-(Peer Reviewed Journal) Yuan, K., Xie, K., Fox, J., Zeng, H., Gao, H., Huang, C., Wu, M. 2013. Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice. Gastroenterology. 145:853–864.Methylselenol, a selenium metabolite, modulates p53 pathway and inhibits the growth of MC-26 colon cancer xenografts in balb/c mice-(Peer Reviewed Journal) Zeng, H., Cheng, W., Johnson, L.K. 2012. Methylselenol, a selenium metabolite, modulates p53 pathway and inhibits the growth of MC-26 colon cancer xenografts in balb/c mice. Journal of Nutritional Biochemistry. DOI:10.1016/j.nutbio.2012.04.008.Activation of ERK signaling and induction of colon cancer cell death by piperlongumine-(Peer Reviewed Journal) Randhawa, H., Kibble, K., Zeng, H., Mayer, M.P., Reindl, K.M. 2013. Activation of ERK signaling and induction of colon cancer cell death by piperlongumine. Toxicology In Vitro. 27:1626-1633.Fatty liver accompanies an increase in Lactobacillus species in the hind gut of C57BL/6 mice fed a high-fat diet-(Peer Reviewed Journal) Zeng, H., Liu, J., Jackson, M.I., Zhao, F., Yan, L., Combs, G.F. 2013. Fatty liver accompanies an increase in Lactobacillus species in the hind gut of C57BL/6 mice fed a high-fat diet. Journal of Nutrition. doi:10.3945/jn.112.172460.Selenium in bone health: roles in antioxidant protection and cell proliferation-(Peer Reviewed Journal) Zeng, H., Cao, J.J., Combs, G.F. 2013. Selenium in bone health: roles in antioxidant protection and cell proliferation. Nutrients. 5:97-110.Methylselenol, a selenium metabolite, inhibits colon cancer cell growth in vitro and in vivo-(Abstract Only) Zeng, H. 2013. Methylselenol, a selenium metabolite, inhibits colon cancer cell growth in vitro and in vivo. Federation of American Societies for Experimental Biology Conference. 27:860.13.Fatty liver accompanies an increase of Lactobacillus acidophilus in the hind gut of C57/BL mice fed a high-fat diet-(Abstract Only) Zeng, H., Liu, J., Jackson, M.I., Yan, L., Combs, G.F. 2013. Fatty liver accompanies an increase of Lactobacillus acidophilus in the hind gut of C57/BL mice fed a high-fat diet. Federation of American Societies for Experimental Biology Conference. 27:1067.4.S-Adenosylmethionine-dependent protein methylation Is
required for expression of selenoprotein P and
gluconeogenic enzymes in HepG2 human hepatocytes-(Peer Reviewed Journal) Jackson, M.I., Cao, J.J., Zeng, H., Uthus, E.O., Combs, G.F. 2012. S-Adenosylmethionine-dependent protein methylation Is required for expression of selenoprotein P and gluconeogenic enzymes in HepG2 human hepatocytes. Journal of Biological Chemistry. 287(43):36455-36464.Selenium and the regulation of cell cycle and apoptosis-(Book / Chapter)Selenium deficiency decreases antioxidative capacity and is detrimental to bone microarchitecture in mice-(Peer Reviewed Journal) Cao, J.J., Gregoire, B.R., Zeng, H. 2012. Selenium deficiency decreases antioxidative capacity and is detrimental to bone microarchitecture in mice. Journal of Nutrition. 142:1526-1531.8-oxoguanine DNA glycosylase 1-deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice-(Peer Reviewed Journal) Li, G., Yuan, K., Fox, J., Gaid, M., Seeger, D., Weaver, A., Breitwieser, W., Bansal, A.K., Zeng, H., Gao, H., Wu, M. 2012. 8-oxoguanine DNA glycosylase 1-deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice. Free Radicals in Biology and Medicine. 15;52(2):392-401.Effect of dietary selenium and cancer cell xenograft on peripheral T and B lymphocytes in adult nude mice-(Peer Reviewed Journal) Cheng, W., Holmstrom, A., Li, X., Wu, R.T., Zeng, H., Xiao, Z. 2012. Effect of dietary selenium and cancer cell xenograft on peripheral T and B lymphocytes in adult nude mice. Biological Trace Element Research. 146:230-235.Methylselenol, a selenium metabolite, plays common and different roles in cancerous colon HCT116 cell and noncancerous NCM460 colon cell proliferation-(Peer Reviewed Journal) Zeng, H., Briske Anderson, M.J., Wu, M., Moyer, M.P. 2012. Methylselenol, a selenium metabolite, plays common and different roles in cancerous colon HCT116 cell and noncancerous NCM460 colon cell proliferation. Nutrition and Cancer. 64(1):128-135.Differential responses to selenomethioinine supplementation by sex and genotype in healthy adults-(Peer Reviewed Journal) Combs, G.F., Jackson, M.I., Watts, J.J., Johnson, L.K., Zeng, H., Idso, J.P., Schomburg, L., Hoeg, A., Hoefig, C.S., Chiang, E.C., Waters, D.J., Tsuji, P.A., Davis, C.D., Milner, J.A. 2012. Differential responses to selenomethioinine supplementation by sex and genotype in healthy adults. British Journal of Nutrition. 107:1514-1525.Determinants of selenium status in healthy adults-(Peer Reviewed Journal) Combs, G.F., Watts, J.J., Jackson, M.I., Johnson, L.K., Zeng, H., Scheett, A.J., Uthus, E.O., Schomburg, L., Hoeg, A., Hoefig, C.S., Davis, C.D., Milner, J.A. 2011. Determinants of selenium status in healthy adults. Nutrition Journal. 10(75):1-10.Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice-(Peer Reviewed Journal) Holmstrom, A., Zeng, H., Lei, K., Cheng, W., Wu, R. 2012. Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice. Journal of Nutritional Biochemistry. 23(9):1086-91.Methylselenol, a selenium metabolite, plays a critical role in inhibiting colon cancer cell growth in vitro and in vivo-(Abstract Only)Dietary selenium intake increases exon-specific DNA methylation of p53 gene in rat liver and colon mucosa-(Abstract Only)Dietary selenomethionine intake increases exon-specific DNA methylation of p53 gene in rat liver and colon mucosa-(Peer Reviewed Journal) Zeng, H., Yan, L., Cheng, W., Uthus, E.O. 2011. Dietary selenomethionine intake increases exon-specific DNA methylation of p53 gene in rat liver and colon mucosa. Journal of Nutrition. 141(8):1464-1468.Obesity-related colon cancer: dietary factors and their mechanisms of anticancer action-(Peer Reviewed Journal) Zeng, H., Lazarova, D.L. 2011. Obesity-related colon cancer: dietary factors and their mechanisms of anticancer action. Clinical and Experimental Pharmacology and Physiology. 39:161-167.Encapsulation of selenium in chitosan nanoparticles improves selenium availability and protects cells from selenium-induced DNA damage response-(Peer Reviewed Journal) Zhang, S., Luo, Y., Zeng, H., Wang, Q., Tian, F., Song, J., Cheng, W. 2011. Encapsulation of selenium in chitosan nanoparticles improves selenium availability and protects cells from selenium-induced DNA damage response. Journal of Nutritional Biochemistry. 22(12):1137-42.Chemical form of selenium affects its uptake, transport and glutathione peroxidase activity in the human intestinal Caco-2 cell model-(Peer Reviewed Journal) Zeng, H., Jackson, M.I., Cheng, W., Combs, G.F. 2010. Chemical form of selenium affects its uptake, transport and glutathione peroxidase activity in the human intestinal Caco-2 cell model. Biological Trace Element Research. 143:1209-1218.Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep-(Peer Reviewed Journal) Nielsen, F.H., Johnson, L.K., Zeng, H. 2010. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnesium Research. 23(4):158-68.Obesity decreases serum selenium levels in DMBA-induced mammary tumor using Obese Zucker Rat Model-(Abstract Only) Hakkak, R., Zeng, H., Lacher, C.P., Johnson, L.K., Korourian, S. 2011. Obesity decreases serum selenium levels in DMBA-induced mammary tumor using Obese Zucker Rat Model. Federation of American Societies for Experimental Biology Conference. 25:977.12.Effect of dietary selenium on T cell immunity and cancer xenograft in nude mice-(Abstract Only) Holmstrom, A., Li, X., Wu, R.T., Xiao, Z., Zeng, H., Lei, K.Y., Cheng, W. 2011. Effect of dietary selenium on T cell immunity and cancer xenograft in nude mice. Federation of American Societies for Experimental Biology Conference. 25:110.5.Methylselenol, a selenium metabolite, plays a critical role in inhibiting colon cancer cell growth in vitro and in vivo-(Abstract Only) Zeng, H., Briske Anderson, M.J. 2011. Methylselenol, a selenium metabolite, plays a critical role in inhibiting colon cancer cell growth in vitro and in vivo. Federation of American Societies for Experimental Biology Conference. 25:110.4.Chemical form of selenium affects its uptake and transport in the human intestinal cell model, Caco-2-(Abstract Only) Zeng, H., Jackson, M.I., Cheng, W., Combs, G.F. 2011. Chemical form of selenium affects its uptake and transport in the human intestinal cell model, Caco-2. Federation of American Societies for Experimental Biology Conference. 25:786.2.Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epitehlial cells and in mice-(Peer Reviewed Journal) Wu, M., Huang, H., Zhang, W., Kannan, S.H., Weaver, A., Mckibben, M., Herington, D., Zeng, H., Gao, H. 2011. Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epitehlial cells and in mice. Infection and Immunity. 79(1):75-87.Sulforaphane plays common and different roles in tumorigenic and nontumorigenic colon cell growth-(Abstract Only) Zeng, H., Trujillo, O., Moyer, M.P., Botnen, J.H. 2010. Sulforaphane plays common and different roles in tumorigenic and nontumorigenic colon cell growth [abstract]. American Institute for Cancer Research . Poster No. 40.Prolonged  sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells-(Peer Reviewed Journal) Zeng, H., Trujillo, O.N., Moyer, M.P., Botnen, J.H. 2011. Prolonged  sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells. Nutrition and Cancer. 63(2):248-255.The von Hippel-Lindau (VHL) tumor-suppressor gene is down-regulated by selenium deficiency in Caco-2 cells and rat colon mucosa-(Peer Reviewed Journal) Uthus, E.O., Begaye, A., Ross, S., Zeng, H. 2010. The von Hippel-Lindau (VHL) tumor-suppressor gene is down-regulated by selenium deficiency in Caco-2 cells and rat colon mucosa. Biological Trace Element Research. 2011 142:223-231.Pinto beans as a course of bioavailable selenium to support bone structure in mice-(Abstract Only) Cao, J.J., Gregoire, B.R., Zeng, H. 2010. Pinto beans as a course of bioavailable selenium to support bone structure in mice [abstract]. Journal of Bone and Mineral Research. 25(Supplement 1).Methylselenol, a Selenium Metabolite, Plays Common and Different Roles in Colonic Cancer and Nontumorigenic Colonic Cell Growth-(Abstract Only) Zeng, H., Briske Anderson, M.J., Moyer, M.P. 2010. Methylselenol, a Selenium Metabolite, Plays Common and Different Roles in Colonic Cancer and Nontumorigenic Colonic Cell Growth. Journal of Federation of American Societies for Experimental Biology. 24:916.5.Prolonged Sulforaphane Treatment Activates Extracellular-Regulated Kinase 1/2  Signaling in Nontumorigenic Colon Cells but not Colon Cancer Cells-(Abstract Only) Zeng, H., Trujillo, O., Moyer, M.P., Botnen, J.H. 2010. Prolonged Sulforaphane Treatment Activates Extracellular-Regulated Kinase 1/2  Signaling in Nontumorigenic Colon Cells but not Colon Cancer Cells. Journal of Federation of American Societies for Experimental Biology. 24:928.4.Effect of Chitosan on the Induction of DNA Damage Response by Selenium Compounds-(Abstract Only) Zhang, S., Zeng, H., Luo, Y., Wang, Q., Cheng, W. 2010. Effect of Chitosan on the Induction of DNA Damage Response by Selenium Compounds. Journal of Federation of American Societies for Experimental Biology. 24:lb251.Methylselenol, a Selenium Metabolite, Induces Cell Cycle Arrest in G1 Phase and Apoptosis via the Extracellular-Regulated Kinase 1/2 Pathway and Other Cancer Signaling Genes-(Peer Reviewed Journal) Zeng, H., Wu, M., Botnen, J.H. 2009. Methylselenol, a Selenium Metabolite, Induces Cell Cycle Arrest in G1 Phase and Apoptosis via the Extracellular-Regulated Kinase 1/2 Pathway and Other Cancer Signaling Genes. Journal of Nutrition. 139:1613-1618.Deoxycholic Acid and Selenium Metabolite Methylselenol Exert Common and Distinct Effects on Cell Cycle, Apoptosis, and MAP Kinase Pathway in HCT116 Human Colon Cancer Cells-(Peer Reviewed Journal) Zeng, H., Botnen, J.H., Briske Anderson, M.J. 2010. Deoxycholic Acid and Selenium Metabolite Methylselenol Exert Common and Distinct Effects on Cell Cycle, Apoptosis, and MAP Kinase Pathway in HCT116 Human Colon Cancer Cells. Nutrition and Cancer. 62(1):85-92.Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis-(Peer Reviewed Journal) Zeng, H. 2009. Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis. Molecules. 14(3):1263-1278.High Dietary Intake of Sodium Selenite Does Not Affect Gene Mutation Frequency in Rat Colon and Liver-(Peer Reviewed Journal) Zeng, H., Uthus, E.O., Ross, S., Davis, C.D. 2009. High Dietary Intake of Sodium Selenite Does Not Affect Gene Mutation Frequency in Rat Colon and Liver. Biological Trace Element Research. DOI 10.0017/s/12011-009-8348-3. Available: http://www.springerlink.com/humana+press/biochemistry.journal/12011.Genetic Determinants of Responses to Selenium Supplementation-(Abstract Only) Combs, G.F., Zeng, H., Jackson, M.I., Johnson, L.K., Hoeg, A., Schomburg, L., Davis, C.D., Milner, J.A. 2009. Genetic Determinants of Responses to Selenium Supplementation. Journal of Federation of American Societies for Experimental Biology. 23:346.3.Deoxycholic acid and selenium metabolite methylselenol  exert common and distinct effects on cell cycle, apoptosis, and MAP kinase pathway in HCT116 human colon cancer cells-(Abstract Only) Zeng, H., Botnen, J.H., Briske Anderson, M.J. 2009. Deoxycholic acid and selenium metabolite methylselenol  exert common and distinct effects on cell cycle, apoptosis, and MAP kinase pathway in HCT116 human colon cancer cells. Journal of Federation of American Societies for Experimental Biology. 23:338.8.Differential effects of deoxycholic acid versus selenium metabolite methylselenol on cell cycle, apoptosis, and MAP kinase pathway in HCT116 human colon cancer cells-(Abstract Only) Zeng, H., Botnen, J.H., Briske Anderson, M.J. 2009. Differential effects of deoxycholic acid versus selenium metabolite methylselenol on cell cycle, apoptosis, and MAP kinase pathway in HCT116 human colon cancer cells. American Association of Cancer Research Meeting. Published in Abstracts of Poster Presentations. No. 4.Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells-(Peer Reviewed Journal) Zeng, H., Botnen, J.H. 2008. Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 31(2007):155-164Molecular mechanisms of cancer prevention by selenium-(Abstract Only) Zeng, H. 2008. Molecular mechanisms of cancer prevention by selenium. [abstract]. BIT Life Sciences' 1st World Cancer Congress. p. 365.Selenium is critical for the regulation of tumor suppressor and pro-inflammatory gene expresssion in human colon Caco-2 cells-(Abstract Only) Zeng, H., Botnen, J.H. 2008. Selenium is critical for the regulation of tumor suppressor and pro-inflammatory gene expresssion in human colon Caco-2 cells. [abstract] Journal of Federation of American Societies for Experimental Biology. 22:696.2.High dietary intake of sodium selenite does not affect gene mutation frequency in rat colon and liver-(Abstract Only) Zeng, H., Uthus, E.O., Ross, S.A., Davis, C.D. 2008. High dietary intake of sodium selenite does not affect gene mutation frequency in rat colon and liver. [abstract] Journal of Federation of American Societies for Experimental Biology. 22:146.7.A selenium-deficient Caco-2 cell model for assessing differential incorporation of chemical or food selenium into glutathione peroxidase-(Peer Reviewed Journal) Zeng, H., Botnen, J.H., Johnson, L.K. 2008. A selenium-deficient Caco-2 cell model for assessing differential incorporation of chemical or food selenium into glutathione peroxidase. Biological Trace Element Research. 123:98-108.Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells-(Abstract Only) Zeng, H., Botnen, J.H. 2007. Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. In: American Association of Cancer Research Meeting, Advances in Colon Cancer Research, November 14-17, Cambridge, MA. p. A6.Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion-(Review Article) Zeng, H., Combs, G.F. 2008. Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion. Journal of Nutritional Biochemistry. 19:1-7.The von Hippel-Lindau (VHL) tumor-suppressor gene is down-regulated in Caco-2 cells incubated in low-selenium (Se) media-(Abstract Only) Uthus, E.O., Begaye, A., Ross, S.A., Zeng, H. 2007. The von Hippel-Lindau (VHL) tumor-suppressor gene is down-regulated in Caco-2 cells incubated in low-selenium (Se) media [abstract]. Journal of Federation of American Societies for Experimental Biology. 21(5):A717.Chemical forms of selenium affect glutatione peroxidase activity in human Caco-2 cell model-(Abstract Only) Zeng, H., Botnen, J.H. 2007. Chemical forms of selenium affect glutatione peroxidase activity in human Caco-2 cell model [abstract]. Journal of Federation of American Societies for Experimental Biology. 21(5):A105.Copper deficiency decreases the protein expression of Complex IV but not Complex I, II, III and V in mitochondrial respiratory chain in rat heart-(Abstract Only) Zeng, H., Saari, J.T., Johnson, W.T. 2007. Copper deficiency decreases the protein expression of Complex IV but not Complex I, II, III and V in mitochondrial respiratory chain in rat heart [abstract]. Journal of Federation of American Societies for Experimental Biology. 21(5):A722.Copper deficiency decreases the protein expression of Complex IV but not Complex I, II, III, or V in mitochondrial respiratory chain in rat heart-(Peer Reviewed Journal) Zeng, H., Saari, J.T., Johnson, W.T. 2007. Copper deficiency decreases complex IV but not complex I, II, III, or V in the mitochondrial respiratory chain in rat heart. Journal of Nutrition. 137:14-18.CARDIAC NITRIC OXIDE SYNTHASES ARE ELEVATED IN DIETARY COPPER DEFICIENCY-(Peer Reviewed Journal) Saari, J.T., Wold, L.E., Duan, J., Ren, J., Carlson, H.L., Bode, A.M., Lentsch, A.B., Zeng, H., Schuschke, D.A. 2006. Cardiac nitric oxide synthases are elevated in dietary copper deficiency. Journal of Nutritional Biochemistry. doi:10.1016/j.jnutbio.2006.07.006.THE SELENIUM METABOLITE METHYLSELENOL INHIBITS THE MIGRATION AND INVASION POTENTIAL OF HT1080 TUMOR CELLS-(Peer Reviewed Journal) Zeng, H., Briske-Anderson, M.J., Idso, J.P., Hunt, C. 2006. The selenium metabolite methylselenol inhibits the migration and invasion potential of HT1080 tumor cells. Journal of Nutrition. 136:1528-1532.NEW FINDINGS ON PROTEIN EXPRESSION ON COPPER DEFICIENT RAT HEART WITH PROTEOMIC APPROACH-(Abstract Only) Zeng, H., Saari, J.T. 2006. New findings on protein expression on copper deficient rat heart with proteomic approach [abstract]. FASEB J. 20(4):A553.SELENIUM METABOLITE METHYLSELENOL INHIBITS MIGRATION AND INVASION POTENTIAL OF HT1080 TUMOR CELLS-(Abstract Only) Zeng, H., Briske Anderson, M.J., Idso, J.P., Hunt, C. 2006. Selenium metabolite methylselenol inhibits migration and invasion potential of HT1080 tumor cells [abstract]. FASEB J. 20(5):A1011.COPPER DEFICIENCY INCREASES FIBULIN-5 (DANCE/EVEC) BUT DECREASES CYTOCHROME C OXIDASE VIB EXPRESSION IN RAT HEART-(Peer Reviewed Journal) Zeng, H., Saari, J.T., Dahlen, G.M. 2005. Copper deficiency increases fibulin-5 (dance/evec) but decreases cytochrome c oxidase vib expression in rat heart. Inorganic Biochemistry. 100:186-91.MECHANISTIC ASPECTS OF THE INTERACTION BETWEEN SELENIUM AND ARSENIC-(Peer Reviewed Journal) Zeng, H., Uthus, E.O., Combs, G.F. 2005. Mechanistic aspects of the interaction between selenium and arsenic. Inorganic Biochemistry. 99:1269-74.INHIBITORY EFFECT OF PROLONGED-BUTYRATE TREATMENT ON MIGRATION AND INVASION OF HT1080 TUMOR CELLS-(Abstract Only) Zeng, H., Briske-Anderson, M. 2005. Inhibitory effect of prolonged-butyrate treatment on migration and invasion of HT1080 tumor cells [abstract]. The Federation of American Societies for Experimental Biology Journal. 19(5):A1693.PROLONGED BUTYRATE TREATMENT INHIBITS THE MIGRATION AND INVASION OF POTENTIAL HT1080 TUMOR CELLS-(Peer Reviewed Journal) Zeng, H., Briske Anderson, M.J. 2005. Prolonged butyrate treatment inhibits the migration and invasion of potential HT1080 tumor cells. Journal of Nutrition. 135:291-295.INCREASED TYPE I COLLAGEN CONTENT AND DNA BINDING ACTIVITY OF A SINGLE-STRANDED CYTOSINE-RICH SEQUENCE IN THE HIGH-SALT BUFFER PROTEIN EXTRACT OF THE COPPER-DEFICIENT RAT HEART-(Peer Reviewed Journal) Zeng, H., Saari, J.T. 2004. Increased type I collagen content and DNA binding activity of a single-stranded, cytosine-rich sequence in the high-salt buffer protein extract of the copper-deficient rat heart. Journal of Nutritional Biochemistry. 15:694-99.IRON ABSORPTION BY HETEROZYGOUS CARRIERS OF THE HFE C282Y MUTATION ASSOCIATED WITH HEMOCHROMATOSIS-(Peer Reviewed Journal) Hunt, J.R., Zeng, H. 2004. Iron absorption by heterozygous carriers of the HFE C282Y mutation associated with hemochromatosis. American Journal of Clinical Nutrition. 80:924-31.INCREASED TYPE I COLLAGEN CONTENT AND DNA BINDING ACTIVITY OF A SINGLE-STRANDED CYTOSINE-RICH SEQUENCE IN THE NUCLEAR EXTRACT OF THE COPPER-DEFICIENT RAT HEART-(Abstract Only) Zeng, H., Saari, J.T. 2004. Increased type I collagen content and DNA binding activity of a single-stranded cytosine-rich sequence in the nuclear extract of the copper-deficient rat heart [abstract]. The Federation of American Societies for Experimental Biology Journal. 18:A914.HEME AND NONHEME IRON ABSORPTION IN HUMANS HETEROZYGOUS FOR THE C282Y HFE MUTATION ASSOCIATED WITH HEMOCHROMATOSIS-(Abstract Only) Hunt, J.R., Zeng, H. 2004. Heme and nonheme iron absorption in humans heterozygous for the C282Y HFE mutation associated with hemochromatosis. Journal of Federation of American Societies for Experimental Biology. 18:A766-A767.COPPER INHIBITION OF SELENITE-INDUCED CELL CYCLE ARREST APPEARS TO BE EXTRACELLULAR-(Abstract Only) Zeng, H., Botnen, J.H. 2004. Copper inhibition of selenite-induced cell cycle arrest appears to be extracellular. Journal of Federation of American Societies for Experimental Biology. 18:A914.THIOREDOXIN REDUCTASE IN HUMAN HEPATOMA CELLS IS TRANSCRIPTIONALLY REGULATED BY SULFORAPHANE AND OTHER ELECTROPHILES VIA AN ANTIOXIDANT RESPONSE ELEMENT-(Peer Reviewed Journal) Hintze, K.J., Wald, K., Jeffery, E.H., Finley, J.W., Zeng, H. 2003. Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element. Journal of Nutrition. 133:2721-2727.THIOREDOXIN REDUCTASE IN HUMAN HEPATOMA CELLS IS TRANSCRIPTIONALLY REGULATED BY SULFORAPHANE AND OTHER ELECTROPHILES VIA AN ANTIOXIDANT RESPONSE ELEMENT-(Peer Reviewed Journal) Hintze, K.J., Wald, K.A., Zeng, H., Jeffery, E.H., Finley, J.W. 2003. Thioredoxin reductase by sulforaphane and other electrophiles via an antioxidant response element.  Journal of Nutrition. 133:2721-2727.DOWN-REGULATION OF PROLIFERATING CELL NUCLEAR ANTIGEN GENE EXPRESSION OCCURS DURING CELL CYCLE ARREST INDUCED BY HUMAN FECAL WATER IN COLONIC HT-29 CELLS-(Peer Reviewed Journal) Zeng, H., Davis, C.D. 2003. Down-regulation of proliferating cell nuclear antigen gene expression occurs during cell cycle arrest induced by human fecal water in colonic HT-29 cells. Journal of Nutrition. 133:2682-2687.HEME AND NONHEME IRON ABSORPTION IN HUMANS WITH C282Y AND H63D HFE MUTATIONS ASSOCIATED WITH HEMOCHROMATOSIS-(Abstract Only) Hunt, J.R., Zeng, H. 2003. Heme and nonheme iron absorption in humans with the C282Y and H63D mutations associated with hemochromatosis [abstract]. BioIron 2003 Symposium, May 4-9, 2003, Washington, D.C. Abstract #62. p.166.COPPER MAY INTERACT WITH SELENITE EXTRACELLULARLY IN CULTURED HT-29 CELLS-(Peer Reviewed Journal) Zeng, H. and Botnen, J.H. 2004. Copper may interact with selenite extracellularly in cultured HT-29 cells. Journal of Nutritional Biochemistry. 15:179-184.GENOMIC AND PROTEOMIC TECHNIQUES AND THEIR APPLICATION IN SELENIUM RESEARCH-(Peer Reviewed Journal) Zeng, H. 2003. Genomic and proteomic techniques and their application in selenium research. Current Pharmacogenomics. 1:59-65.IMPACT OF ESTROGEN REPLACEMENT ON VENTRICULAR MYOCYTE CONTRACTILE FUNCTION AND PROTEIN KINASE B/AKT ACTIVATION-(Peer Reviewed Journal) Ren, J., Kinze, K., Roughead, Z.K., Duan, J., Colligan, P.B., Ren, B.H., Lee, K.J., Zeng, H. 2003. Impact of estrogren replacement on ventricular myocyte contractile function and protein kinase B/AKT activation. American Journal of Physiology. 284:H1800-H1807.EFFECT OF SELENIUM-ENRICHED BROCCOLI DIET ON DIFFERENTIAL GENE EXPRESSION IN MIN MOUSE LIVER-(Abstract Only) Zeng, H., Davis, C.D., Finley, J.W. 2003. Effect of selenium-enriched broccoli diet on differential gene expression in min mouse liver [abstract]. Journal of Federation of American Societies for Experimental Biology. 17(5):A1159.THE MOLECULAR BASIS OF SELENITE/SELENO-METHIONINE AT PHYSIOLOGICAL         CONCENTRATIONS IN PROMOTION OF HL-60 CELL CYCLE PROGRESSION-(Abstract Only) Zeng, H. 2002. The molecular basis of selenite/seleno-methionine at physiological concentrations in promotion of HL-60 cell cycle progression [abstract]. The Federation of American Societies for Experimental Biology Journal. 16:A264.SELENITE AND SELENOMETHIONINE PROMOTE HL-60 CELL CYCLE PROGRESSION-(Peer Reviewed Journal) Zeng, H. 2002. Selenite and selenomethionine promote HL-60 cell cycle progression. Journal of Nutrition. 132:674-679.HEME AND NONHEME IRON ABSORPTION BY HUMANS WITH THE C282Y AND H63D HFE     MUTATIONS ASSOCIATED WITH HEMOCHROMATOSIS-(Abstract Only) Hunt, J.R., Zeng, H. 2002. Heme and nonheme iron absorption by humans with the C282Y and H63D HFE mutations associated with hemochromatosis [abstract]. The Federation of American Societies for Experimental Biology Journal. 16:A22.SELENIUM-ENRICHED BROCCOLI DECREASES INTESTINAL TUMORIGENESIS IN MULTIPLE  INTESTINAL NEOPLASIA (MIN) MICE-(Peer Reviewed Journal) Davis, C.D., Zeng, H., Finley, J.W. 2002. Selenium-enriched broccoli decreases intestinal tumorigenesis in multiple intestinal neoplasia (Min) mice. Journal of Nutrition. 132:307-309.ARSENIC SUPPRESSES NECROSIS INDUCED BY SELENITE IN HUMAN LEUKEMIA HL-60    CELLS-(Peer Reviewed Journal) Zeng, H. 2001. Arsenic suppresses necrosis induced by selenite in human leukemia HL-60 cells. Biological Trace Element Research. 83:1-15.THE EFFECT OF ARSENIC ON THE SELENIUM-INDUCED CELL DEATH PATHWAY-(Abstract Only) Zeng, H. 2001. The effect of arsenic on the selenium-induced cell death pathway [abstract]. The Federation of American Societies for Experimental Biology Journal. 15:A604.
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