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                    U.S. DEPARTMENT OF AGRICULTURE
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Gisselle  Medina
                        Foreign Animal Disease Research

                        




                        
                        RESEARCH SCIENTIST
                        Phone:    
                        
                        
                        Fax: (Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            ProjectsIntervention Strategies to Control and Eradicate Foreign Animal Diseases of Swine
                                                    In-House Appropriated
                                                                    (D)Accession Number: 441308Development of a Novel Epitope-based Vaccine Candidate for FMDV
                                                    Non-Assistance Cooperative Agreement
                                                                    (S)Accession Number: 444597Increasing the Efficacy of the Ad5-FMD Vaccine Using a Multi-Gene Delivery System
                                                    Non-Assistance Cooperative Agreement
                                                                    (S)Accession Number: 436872Generation of Replication Competent Adenovirus Type 5 Foot-and-Mouth Disease Vaccine with Increased Efficacy
                                                    Non-Assistance Cooperative Agreement
                                                                    (S)Accession Number: 438042**Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)Exploring the molecular basis of vesicular stomatitis virus pathogenesis in swine: insights from expression profiling of primary macrophages infected with M51R mutant virus
                                                        

- (Peer Reviewed Journal)Velazquez Salinas, L., Medina, G.N., Valdez, F., Collinson, S., Zarate, S., Zhu, J.J., Rodriguez, L.L. 2023. Exploring the molecular basis of vesicular stomatitis virus pathogenesis in swine: insights from expression profiling of primary macrophages infected with M51R mutant virus. Pathogens. 12(7). Article 896. https://doi.org/10.3390/pathogens12070896.Understanding the molecular mechanisms of attenuation in codon deoptimized FMDV strains
                                                        

- (Abstract Only)Medina, G.N., Spinard Iii, E.J., Azzinaro, P.A., Rodriguez-Calzada, M., Rieder, A.E., Diaz San Segundo, F.C., De Los Santos, T.B. 2023. Understanding the molecular mechanisms of attenuation in codon deoptimized FMDV strains. Meeting Abstract. https://doi.org/10.3390/v15061332.Deoptimization of FMDV P1 region results in robust serotype-independent viral attenuation
                                                        

- (Peer Reviewed Journal)Medina, G.N., Diaz-San Segundo, F., Spinard III, E.J., Azzinaro, P.A., Rodriguez-Calzada, M., Gutkoska, J.R., Kloc, A., Rieder, A.E., Mueller, S., De Los Santos, T.B. 2023. Deoptimization of FMDV P1 region results in robust serotype-independent viral attenuation. Viruses. 15(6). https://doi.org/10.3390/v15061332.Recoding the genome of FMDV: A path for the development of live attenuated vaccine (LAV) candidates against FMD
                                                        

- (Proceedings)Medina, G.N., Diaz San Segundo, F.C., De Los Santos, T.B. 2023. Recoding the genome of FMDV: A path for the development of live attenuated vaccine (LAV) candidates against FMD. Global Foot-and Mouth Disease Research Alliance (GFRA). https://doi.org/10.3390/v15061332.Evaluation of potential in vitro recombination events in codon deoptimized FMDV strains
                                                        

- (Peer Reviewed Journal)Spinard III, E.J., Fish, I., Azzinaro, P.A., Rodriguez-Calzada, M., Hartwig, E.J., Smoliga, G.R., Arzt, J., De Los Santos, T.B., Medina, G.N. 2022. Evaluation of potential in vitro recombination events in codon deoptimized FMDV strains. Viruses. 15(3). https://doi.org/10.3390/v15030670.Evaluation of potential recombination events in codon deoptimized FMDV strains
                                                        

- (Abstract Only)Spinard, E., Fish, I., Azzinaro, P.A., Hartwig, E.J., Smoliga, G.R., Mogulothu, A., Rodriguez-Calzada, M., Arzt, J., De Los Santos, T.B., Medina, G.N. 2023. Evaluation of potential recombination events in codon deoptimized FMDV strains. Meeting Abstract. https://doi.org/10.3390/v15030670.Mutation of FMDV Lpro H138 reside outside substrate binding domain drives viral attenuation in vitro and in swine
                                                        

- (Peer Reviewed Journal)Azzinaro, P.A., Medina, G.N., Rai, D., Ramirez Medina, E., Spinard Iii, E.J., Zhu, J.J., Rieder, A.E., De Los Santos, T.B., Diaz San Segundo, F.C. 2022. Mutation of FMDV Lpro H138 reside outside substrate binding domain drives viral attenuation in vitro and in swine. Frontiers in Veterinary Science. https://www.frontiersin.org/articles/10.3389/fvets.2022.1028077/full.Mutation of FMDV Lpro residues outside substrate binding domain drives viral attenuation
                                                        

- (Abstract Only)Diaz San Segundo, F.C., Azzinaro, P.A., Zhu, J.J., Medina, G.N., De Los Santos, T.B. 2022. Mutation of FMDV Lpro residues outside substrate binding domain drives viral attenuation. Meeting Abstract. https://doi.org/10.3389/fvets.2022.1028077.Foot-and-Mouth Disease virus interserotypic recombination in superinfected carrier cattle
                                                        

- (Peer Reviewed Journal)Fish, I., Bertram, M.R., Stenfeldt, C., Smoliga, G.R., Hartwig, E.J., Holinka-Patterson, L.G., De Los Santos, T.B., Spinard III, E.J., Medina, G.N., Arzt, J., Azzinaro, P.A. 2022. Foot-and-Mouth Disease virus interserotypic recombination in superinfected carrier cattle. Pathogens.  https://doi.org/10.3390/pathogens11060644.Pegylated Interferon vs Standard Interferon: a promising biotherapeutic platform to get strong and long-lasting antiviral activity against FMDV
                                                        

- (Proceedings)Diaz San Segundo, F.C., Medina, G.N., De Los Santos, T.B. 2021. Pegylated Interferon vs Standard Interferon: a promising biotherapeutic platform to get strong and long-lasting antiviral activity against FMDV. Global Foot-and Mouth Disease Research Alliance (GFRA). https://doi.org//10.3389/fmicb.2021.668890.FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation
                                                        

- (Peer Reviewed Journal)Visser, L.J., Medina, G.N., Rabouw, H.H., De Groot, R.J., Langereis, M.A., De los Santos, T.B., Van Kuppeveld, F.J. 2018. FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation. Journal of Virology. https://doi.org/10.1128/JVI.00922-18.Control of foot-and-mouth disease by using replication-defective human adenoviruses to deliver vaccines and biotherapeutics

- (Book / Chapter)Evaluation of fiber-modified adenovirus vector-vaccine against foot-and-mouth diseaes in cattle

- (Peer Reviewed Journal)Montiel, N., Medina, G.N., Sturza, D., Diaz-San Segundo, F., Ramirez-Medina, E., Grubman, M.J., De Los Santos, T.B. 2016. Evaluation of fiber-modified adenovirus vector-vaccine against foot-and-mouth diseaes in cattle. Clinical and Vaccine Immunology. 23:125-136. doi: 10.1128/CVI.00426-15.Synonymous deoptimization of the foot-and-mouth disease virus P1 coding region causes attenuation in vivo while inducing a strong neutralizing antibody response

- (Peer Reviewed Journal)Diaz-San Segundo, F., Koster, M.J., Ramirez-Medina, E., Medina, G.N., Velazquez-Salinas, L., Grubman, M.J., De Los Santos, T.B. 2015. Synonymous deoptimization of the foot-and-mouth disease virus P1 coding region causes attenuation in vivo while inducing a strong neutralizing antibody response. Journal of Virology. 90:1298-1310. doi:10.1128/JVI.02167-15.Animal health: foot-and-mouth disease

- (Book / Chapter)Diaz San Segundo, F.C., Medina, G.N., Grubman, M.J., De Los Santos, T.B. 2014. Animal health: Foot-and-Mouth Disease. In: Van Alfen, N.K., editor. Encyclopedia of Agriculture and Food Systems. 2nd edition. United States of America: Elsevier/Academic Press. p. 327-345.


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