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ARS Home Southeast Area New Orleans, Louisiana Southern Regional Research Center Commodity Utilization Research People & Locations







Kandan  Sethumadhavan
                        Commodity Utilization Research

                        




                        
                        Chemist
                        Phone: (504) 286-4368
                        
                        
                        Fax: (504) 286-4217(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            **Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)Improvement of the solubility of glandless cottonseed protein isolate for fortified beverage applications

- (Abstract Only)Selection of qPCR reference gene for human colon cancer cells in cottonseed bioactive research

- (Abstract Only)Plant polyphenol gossypol induced cell death and its association with gene expression in mouse macrophages
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K. 2023. Plant polyphenol gossypol induced cell death and its association with gene expression in mouse macrophages. Biomolecules. 13(4). Article 624. https://doi.org/10.3390/biom13040624.Characterization of the solubility of proteins from glandless cottonseeds

- (Proceedings)Cao H., Sethumadhavan, K., and Pelitire. S.M., 2023. Characterization of protein solubility from glandless cottonseed. In: Proceedings of Beltwide Cotton Conferences, January 10-12, 2023, New Orleans, Louisiana. p. 47-52.Characterization of protein solubility from glandless cottonseed

- (Abstract Only)Bioactivity of cottonseed-derived materials for nutrition and health

- (Abstract Only)Identification of Bcl2 as a stably expressed qPCR reference gene for human colon cancer cells treated with cottonseed-derived gossypol and bioactive extracts and bacteria-derived lipopolysaccharides
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K. 2022. Identification of Bcl2 as a stably expressed qPCR reference gene for human colon cancer cells treated with cottonseed-derived gossypol and bioactive extracts and bacteria-derived lipopolysaccharides. Molecules. https://doi.org/10.3390/molecules27217560.Cottonseed kernel extracts downregulate proinflammatory cytokine gene expression in mouse macrophages

- (Abstract Only)Survey of cottonseed extracts on gene expression in human colon cancer cells

- (Proceedings)Cao, H., Sethumadhavan, K. 2022. Survey of cottonseed extracts on gene expression in human colon cancer cells. In: Proceedings of the National Cotton Council Beltwide Cotton Conferences, January 4-6, 2022, San Antonio, Texas. p. 478-491.Gossypol effects on mammalian cell growth and gene expression

- (Abstract Only)Cottonseed extracts regulate gene expression in human colon cancer cells
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K., Wu, X., Zeng, X., Zhang, L. 2022. Cottonseed extracts regulate gene expression in human colon cancer cells. Scientific Reports. 12:1039. https://doi.org/10.1038/s41598-022-05030-3.Survey of cottonseed extracts on gene expression in mammalian cells

- (Abstract Only)Cottonseed-derived gossypol and ethanol extracts differentially regulate cell viability and VEGF gene expression in mouse macrophages
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K., Wu, X., Zeng, X. 2021. Cottonseed-derived gossypol and ethanol extracts differentially regulate cell viability and VEGF gene expression in mouse macrophages. Scientific Reports. 11:15700. https://doi.org/10.1038/s41598-021-95248-4.Evidence for glandless cottonseed kernel extract down-regulating gene expression in human colon cancer cells

- (Abstract Only)Gossypol: friend or foe for human nutrition and health?

- (Abstract Only)Cottonseed extracts regulate cell viability and gene expression in human colon cancer cells

- (Abstract Only)Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells

- (Abstract Only)Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K., Cao, F., Wang, T.T.Y. 2021. Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells. Scientific Reports. 11:5922. https://doi.org/10.1038/s41598-021-84970-8.Cottonseed bioactive compounds and peptides

- (Proceedings)Cao, H., Sethumadhavan, K. 2020. Cottonseed bioactive compounds and peptides. Proceedings of 2020 Beltwide Cotton Conferences. p. 270-281.Regulation of cell viability and anti-inflammatory tristetraprolin family gene expression in mouse macrophages by cottonseed extracts
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K. 2020. Regulation of cell viability and anti-inflammatory tristetraprolin family gene expression in mouse macrophages by cottonseed extracts. Scientific Reports. 10:775. https://doi.org/10.1038/s41598-020-57584-9.Gossypol but not cottonseed extracts or lipopolysaccharides stimulates HuR gene expression in mouse cells
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K. 2019. Gossypol but not cottonseed extracts or lipopolysaccharides stimulates HuR gene expression in mouse cells. Journal of Functional Foods. 59:25-29. https://doi.org/10.1016/j.jff.2019.05.022.Cinnamon polyphenol extract and insulin regulate diacylglycerol acyltransferase gene expression in mouse adipocytes and macrophages
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K., Li, K., Boue, S.M., Anderson, R.A. 2019. Cinnamon polyphenol extract and insulin regulate diacylglycerol acyltransferase gene expression in mouse adipocytes and macrophages. Plant Foods for Human Nutrition. 74(1):115-121. https://doi.org/10.1007/s11130-018-0709-7.Isolation of cottonseed extracts that affect human cancer cell growth
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K., Bland, J.M. 2018. Isolation of cottonseed extracts that affect human cancer cell growth. Scientific Reports. 8:10458. https://doi.org/10.1038/s41598-018-28773-4.Cottonseed extracts and gossypol regulate diacylglycerol acyltransferase gene expression in mouse macrophages
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K. Cottonseed extracts and gossypol regulate diacylglycerol acyltransferase gene expression in mouse macrophages. Journal of Agricultural and Food Chemistry. 66(24):6022-6030. https://doi.org/10.1021/acs.jafc.8b01240Aspergillus flavus growth and aflatoxin production as influenced by total lipid content during growth and development of cottonseed
                                                        

- (Peer Reviewed Journal)Rajasekaran, K., Ford, G., Sethumadhavan, K., Carter Wientjes, C., Bland, J., Cao, H., Bhatnagar, D. 2016. Aspergillus flavus growth and aflatoxin production as influenced by total lipid content during growth and development of cottonseed. Journal of Crop Improvement. 31(1):91-99. https://doi.org/10.1080/15427528.2016.1263811.Identification of an Mg2+-independent soluble phosphatidate phosphatase in cottonseed (Gossypium hirsutum L.)
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K., Rajasekaran, K. 2016. Identification of an Mg2+-independent soluble phosphatidate phosphatase in cottonseed (Gossypium hirsutum L.). Advances in Biological Chemistry. 6(6):169-179.Characterization of a soluble phosphatidic acid phosphatase in bitter melon (Momordica charantia)
                                                        

- (Peer Reviewed Journal)Cao, H., Sethumadhavan, K., Grimm, C.C., Ullah, H.J. 2014. Characterization of a soluble phosphatidic acid phosphatase in bitter melon (Momordica charantia). PLoS One. 9(9):e106403.Peptide conjugated cellulose nanocrystals with sensitive
human neutrophil elastase sensor activity

- (Peer Reviewed Journal)Edwards, J.V., Prevost, N.T., Sethumadhavan, K., Ullah, A.H., Condon, B.D. 2013. Peptide conjugated cellulose nanocrystals with sensitive human neutrophil elastase sensor activity. Cellulose. 20(3):1223-1235.Molecular properties of the class III subfamily of acyl-coenyzme A binding proteins from tung tree (Vernicia fordii)

- (Peer Reviewed Journal)Pastor, S., Sethumadhavan, K., Ullah, A.H., Gidda, S., Cao, H., Mason, C., Chapital, D., Scheffler, B., Mullen, R., Dyer, J., Shockey, J. 2013. Molecular properties of the class III subfamily of acyl-coenyzme A binding proteins from tung tree (Vernicia fordii). Plant Science. 203-204:79-88.Colorimetric elastase sensor with peptide conjugated cellulose nanocrystals is interfaced to dialysis membranes

- (Abstract Only)Identification of a soluble phosphatidate phosphohydrolase in the developing cotyledons of Morordica charantia

- (Peer Reviewed Journal)Ullah, A.H.J., Sethumadhavan, K. 2013. Identification of a soluble phosphatidate phosphohydrolase in the developing cotyledons of Morordica charantia. Advances in Biological Chemistry. (3):11-17.Measuring phosphatidic acid phosphatase (EC 3.1.3.4) activity using two phosphomolybdate-based colorimetric methods

- (Peer Reviewed Journal)Ullah, A.H.J., Sethumadhavan, K., Shockey, J. 2012. Measuring phosphatidic acid phosphatase (EC 3.1.3.4) activity using two phosphomolybdate-based colorimetric methods. Advances in Biological Chemistry. 2:416-421.Purification, characterization, and bioinformatics studies of phosphatidic acid phosphohydrolase from Lagenaria siceraria

- (Peer Reviewed Journal)Ullah, A.H.J., Sethumadhavan, K., Grimm, C., Shockey, J. 2012. Purification, characterization, and bioinformatics studies of phosphatidic acid phosphohydrolase from Lagenaria siceraria. Advances in Biological Chemistry.  2(4):403-410.Purification, characterization, and bioinformatics studies of phosphatidic acid phosphohydrolase from Lagenaria siceraria

- (Peer Reviewed Journal)Ullah, A.H.J., Sethumadhavan, K., Grimm, C., Shockey, J. 2012. Purification, characterization, and bioinformatics studies of phosphatidic acid phosphohydrolase from Lagenaria siceraria. Advances in Biological Chemistry. 2(4):403-410.Elimination of a disulfide bridge in Aspergillus niger NRRL 3135 Phytase (PhyA) enhances heat tolerance and optimizes its temperature versus activity profile

- (Peer Reviewed Journal)Mullaney, E., Sethumadhavan, K., Boone, S., Lei, X.G., Ullah, A.H.J. 2012. Elimination of a disulfide bridge in Aspergillus niger NRRL 3135 Phytase (PhyA) enhances heat tolerance and optimizes its temperature versus activity profile. Advances in Biological Chemistry. 2(4):372-378.Ethanol tolerance in Aspergillus niger and Escherichia coli phytase

- (Peer Reviewed Journal)Mullaney, E.J., Sethumadhavan, K., Boone, S., Ullah, A.H.J. 2012. Ethanol tolerance in Aspergillus niger and Escherichia coli phytase. Advances in Microbiology. 2(3):395-398.A single mutation in the hepta-peptide active site of Aspergillus niger PhyA phytase leads to myriad of biochemical changes

- (Peer Reviewed Journal)Ullah, A.H.J., Sethumadhavan, K., Boone, S., Mullaney, E.J. 2012. A single mutation in the hepta-peptide active site of Aspergillus niger PhyA phytase leads to myriad of biochemical changes. Advances in Microbiology. 2(3):388-394.Vanadate inhibition of fungal phyA and bacterial appA2 histidine acid phosphatases

- (Peer Reviewed Journal)Ullah, A.H., Sethumadhavan, K., Mullaney, E.J. 2011. Vanadate inhibition of fungal phyA and bacterial appA2 histidine acid phosphatases. Journal of Agricultural and Food Chemistry. (59)1739-1743.Immobilization of lysozyme on cotton fabrics; synthesis, characterication, and activity

- (Peer Reviewed Journal)Edwards, J.V., Prevost, N.T., Condon, B.D., Sethumadhavan, K., Ullah, A.H. 2011. Immobilization of lysozyme on cotton fabrics; synthesis, characterication, and activity. American Association of Textile Chemists and Colorists Review. 11(3):73-79.Non-essential A69E mutations in the active site of Aspergillus niger phyA phytase leads to myriads of changes

- (Abstract Only)Ullah, A.H., Sethumadhavan, K., Boone, S.A., Mullaney, E.J. Non-essential A69E mutations in the active site of Aspergillus niger phyA phytase leads to myriads of changes (Abstract).Site-directed mutagenesis of disulfide bridges in Aspergillus niger NRRL 3135 phytase (PhyA), their expression in Pichia pastoris and catalytic characterization

- (Peer Reviewed Journal)Mullaney, E.J., Locovare, H., Sethumadhavan, K., Boone, S., Lei, X.G., Ullah, A.H.J. 2010. Site-directed mutagenesis of disulfide bridges in Aspergillus niger NRRL 3135 phytase (PhyA), their expression in Pichia pastoris and catalytic characterization. Applied Microbiology and Biotechnology. 87(4):1367-1372.Impact of Assay conditions on activity estimate and kinetics comparison of Aspergillus niger PhyA and Escherichia coli AppA2 phytases

- (Peer Reviewed Journal)Weaver, J.D., Ullah, A.H., Sethumadhavan, K., Mullaney, E.J., Lei, X.G. 2009. Comparisons of activity assay methods and kinetics of Aspergillus niger PhyA and Escherichia coli AppA2 phytases. Journal of Agriculture and Food Chemistry.  57:5315-5320.Immobilization of lysozyme on cotton fabrics; synthesis, characterization, and activity

- (Proceedings)Prevost, N.T., Edwards, J.V., Condon, B.D., Batiste, S.L., Howley, P.S., Sethumadhavan, K., Ullah, A.H. 2009. Immobilization of lysozyme on cotton fabrics; synthesis, characterization, and activity. Proceedings of the National Cotton Council Beltwide Cotton Conference. 1398-1401.Unfolding and Refolding of Aspergillus Niger PhyB Phytase: Role of Disulfide Bridges

- (Peer Reviewed Journal)Ullah, A.H., Sethumadhavan, K., Mullaney, E.J. 2008. Unfolding and Refolding of Aspergillus Niger PhyB Phytase: Role of Disulfide Bridges. Journal of Agriculture and Food Chemistry. 56(17):8179-8183.Kinetic Characterization of O-Phospho-L-Tyrosine Phosphohydrolase Activity of Two Fungal Phytases.

- (Peer Reviewed Journal)Ullah, A.H., Sethumadhavan, K., Mullaney, E.J. 2008. Kinetic characterization of o-phospho-L-tyrosine phosphohydrolase activity of two fungal phytases. Journal of Agriculture and Food Chemistry. 56(16):7467-7471.Salt Effect on the pH Profile and Kinetic Parameters of Microbial Phytases

- (Peer Reviewed Journal)Ullah, A.H., Sethumadhavan, K., Mullaney, E.J.  2008.  Salt effect on the pH profile and kinetic parameters of microbial phytases.  Journal of Agricultural and Food Chemistry. 56:3398-3402.OPTIMIZING THE PH PROFILE OF FUNGAL PHYTASE THROUGH PROTEIN ENGINEERING ALSO ENHANCES ACTIVITY

- (Abstract Only)Mullaney, E.J., Ullah, A.H., Sethumadhavan, K., Lei2, X. 2007. Optimizing the ph profile of fungal phytase through protein engineering also enhances activity (abstract). Society of Industrial Microbiology Annual Meeting. p. 146.Enzymatic Comparisons of Aspergillus niger PhyA and Escherichia coli AppA2 Phytases

- (Abstract Only)Weaver, J.D., Ullah, A.H., Sethumadhavan, K., Mullaney, E.J., Lei, X.G. 2007. Enzymatic comparisons of Aspergillus Niger PhyA and Escherichia Coli AppA2 Phytases (abstract). Journal of Animal Science. 85(Supplement 1):647.New Uses for Immobilized Enzymes and Substrates on Cotton and Cellulose Fibers

- (Book / Chapter)Edwards, J.V., Ullah, A.H., Sethumadhavan, K., Batiste, S.L., Bel, P., Von Hoven, T.M., Goynes Jr, W.R., Condon, B.D., Pierre, S.C. 2007. New Uses for Immobilized Enzymes & Substrates on Cotton & Cellulose Fibers. American Chemical Society Symposium Series. 972:171-185.MONITORING OF UNFOLDING AND REFOLDING IN FUNGAL PHYTASE (PHYA) BY DYNAMIC LIGHT SCATTERING

- (Peer Reviewed Journal)Ullah, A.H., Sethumadhavan, K., Mullaney, E.J.  2005. Monitoring of unfolding and refolding in fungal phytase (phyA) by dynamic light scattering.  Biochemical and Biophysical Research Communications.  327(4):993-998.UNFOLDING AND REFOLDING STUDIES OF FUNGAL PHYTASE USING DYNAMIC LIGHT SCATTERING

- (Abstract Only)Ullah, A.H., Sethumadhavan, K. Unfolding and refolding studies of fungal phytase using dynamic light scattering(abstract). American Society for Biochemistry & Molecular Biology Annual Meeting 2004 FASEB Journal, Enzyme Structure, and Function. 8(18):C24.FUNGAL PHYA GENE EXPRESSED IN POTATO LEAVES PRODUCES ACTIVE AND STABLE PHYTASE

- (Peer Reviewed Journal)Ullah, A.H., Sethumadhavan, K., Mullaney, E.J., Ziegelhoffer, T., Austin-Phillips, S. 2003. Fungal phyA gene expressed in potato leaves produces active and stable phytase. Biochemical and Biophysical Research Communications. 306(2):603-609.PHYA GENE PRODUCT OF ASPERGILLUS FICUUM AND PENIOPHORA LYCII PRODUCES TWO DISSIMILAR PHYTASES

- (Peer Reviewed Journal)Ullah, A.H., Sethumadhavan, K. 2003. Phya gene product of aspergillus ficuum and peniophora lycii produces two dissimilar phytases. Biochemical and Biophysical Research Communications. 303(2):463-468.GENE CLONING AND CHARACTERIZATION OF PHYTASE ACTIVITY IN FOUR ASPERGILLUS  FUMIGATUS ISOLATES

- (Peer Reviewed Journal)BIOCHEMICAL CHARACTERIZATION OF CLONED ASPERGILLUS FUMIGATUS PHYTASE (PHYA)

- (Peer Reviewed Journal)CHARACTERIZATION OF RECOMBINANT FUNGAL PHYTASE (PHYA) EXPRESSED IN TOBACCO LEAVES

- (Peer Reviewed Journal)MYO-INOSITOL HEXASULFATE IS A POTENT INHIBITOR OF ASPERGILLUS FICUUM       PHYTASE

- (Peer Reviewed Journal)DIFFERENCES IN THE ACTIVE SITE ENVIRONMENT OF ASPERGILLUS FICUUM PHYTASES

- (Peer Reviewed Journal)


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