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ARS Home Plains Area Grand Forks, North Dakota Grand Forks Human Nutrition Research Center People





- Scientists
- Derek Bussan
- Jay Cao
- Shanon Casperson
- Julie Hess
- Forrest Nielsen
- James Roemmich
- Lin Yan
- Huawei Zeng

Lin  Yan    Nutritionist /ARSUserFiles/41193/Images/Yan headshot_1.jpg
 Lin Yan, Ph.D.  Contact information (701) 795-8499lin.yan@usda.gov
 **Biography** Dr. Yan attended graduate school at Texas Tech University, where he earned his doctoral degree in Human Nutrition. Dr. Yan completed his post-doctoral training in selenium and cancer biology at Rutgers University. After that, he was a research faculty member at Creighton University School of Medicine and a Nutrition Scientist at DuPont/Solae Company. In 2007, Dr. Yan joined the staff at the Grand Forks Human Nutrition Research Center as a Research Nutritionist. Dr. Yan conducts research in diet, physical exercise, cancer prevention, and metabolic health.
 **Research Interests** Dr. Yan's research interests are in the area of diet, physical exercise, and cancer prevention. The prevalence of obesity in Western countries, including the United States, has reached epidemic proportions. Obesity is associated with a low-grade proinflammatory metabolic state that contributes to chronic diseases including cancer. Dr. Yan has investigated the roles of dietary modification (for example, energy balance and selenium supplementation) and physical exercise in prevention of obesity-enhanced primary tumorigenesis and metastasis in models for human cancer. Dr. Yan’s recent research focuses on the impact of lifestyle changes on metabolic health. Physiological functions of humans (for example, eating/fasting and wake/sleep patterns) are controlled by the internal biological clock that cycles for approximately every 24 hours. Lifestyle changes in modern world (for example, erratic eating behavior, sleep deprivation, and sedentariness) disrupt the clock and contribute to modern disorders including metabolic dysfunction and obesity. Currently, Dr. Yan works on how changes in dietary practice and physical activity alter the biological clock in major organs (for example, liver and fat tissues) and their effects on the regulation of metabolism. Outcomes from these investigations contribute to the knowledge of the extent to which dietary modification and exercise can improve quality life and promote health and well-being in humans.
 **Research Accomplishments** Selenium is an essential nutrient to humans. It is a nutrient with cancer prevention potentials. Adequate selenium intake has been associated with lower risk of cancer in both epidemiological studies and clinical intervention trials. Dr. Yan investigated the roles of selenium in secondary cancer prevention – the prevention of malignant spread, using models for human cancer. Metastasis is the most devastating aspect of cancer. Dr. Yan demonstrated that dietary supplementation of selenium reduces pulmonary metastasis in a spontaneous metastasis model of Lewis lung carcinoma. This protection can be also observed in mice with the high-fat diet-enhanced metastasis. Furthermore, Dr. Yan found that dietary selenium supplementation reduces primary mammary tumor growth and its spread to the lungs in a model for male breast cancer. Male breast cancer is a rare but aggressive disease in men. It remains an unexplored area in cancer prevention research. Findings from Dr. Yan’s investigation provide laboratory evidence of usefulness of selenium in secondary cancer prevention.
Adipose tissue produces biologically active inflammatory cytokines that contribute to chronic diseases, including cancer. Diet-induced obesity enhances primary mammary tumorigenesis in models for breast cancer and pulmonary metastasis in models for lung cancer. These enhancements occur with increases in body fat mass and elevations in adipokines in blood (for example, monocyte chemotactic protein-1 (MCP1) and plasminogen activator inhibitor-1 (PAI1)). Dr. Yan demonstrated that knockout of MCP1 or PAI1 from the body significantly reduces the high-fat diet-enhanced malignant spread to the lung in a mouse model of Lewis lung carcinoma. Furthermore, Dr. Yan found that depletion of MCP1 from adipose tissues results in fewer and smaller lung metastases in the Lewis lung carcinoma model and a slower growth rate of primary mammary tumorigenesis in the MMTV-PyMT breast cancer model. These findings are laboratory evidence that adipose-produced adipokines directly contribute to malignant progression. It strengthens our knowledge of obesity in cancer promotion and emphasizes the importance of obesity prevention for health maintenance and cancer prevention.
All mammals exhibit daily rhythms in physiological and biological functions. Disruption of the daily rhythms by eating at a “wrong” time may alter the rhythms of energy metabolism and lead to metabolic disorders including obesity. Dr. Yan investigated the effects of timing of food intake on high-fat diet-induced metabolic disturbance and obesity-enhanced primary tumorigenesis and metastasis in models for human cancer. Time-restricted feeding is a tool used to study timing of food intake in rodents that temporally controlling the eating/fasting pattern to a fixed time of the day. Dr. Yan found that time-restricted feeding, which does not affect food intake compared to mice with unrestricted feeding, restores the rhythm of energy expenditure, reduces body adiposity, and improves insulin sensitivity. Furthermore, Dr. Yan demonstrated that time-restricted feeding reduces high-fat diet-enhanced mammary tumorigenesis in the MMTV-PyMT breast cancer model and lung metastasis in the Lewis lung carcinoma model. These findings indicate that maintenance of a healthy eating pattern is beneficial in health promotion and cancer prevention.
 Curriculum Vitae (PDF)
 ProjectsModification of Diurnal Patterns to Promote Health in Models for Human Metabolic DysfunctionIn-House Appropriated (D)Accession Number:436804Clinical ResearchNon-Assistance Cooperative Agreement (S)Accession Number:438433
 Publications(Clicking on the reprint iconReprint Icon  will take you to the publication reprint.)Time-restricted feeding restores metabolic flexibility in adult mice with excess adiposity-(Peer Reviewed Journal) Yan, L., Rust, B., Palmer, D. 2024. Time-restricted feeding restores metabolic flexibility in adult mice with excess adiposity. Frontiers in Nutrition. 11:1-14. https://doi.org/10.3389/fnut.2024.1340735.Time-restricted feeding modifies the fecal lipidome and the gut microbiota-(Peer Reviewed Journal) Rust, B.M., Picklo, M.J., Yan, L., Mehus, A.A., Zeng, H. 2023. Time-restricted feeding modifies the fecal lipidome and the gut microbiota. Nutrients. 15(7):1-17. https://doi.org/10.3390/nu15071562.Metabolomic alteration in mammary glands of pubertal mice fed a high-fat diet-(Peer Reviewed Journal) Yan, L., Rust, B., Sundaram, S., Bukowski, M.R. 2023. Metabolomic alteration in mammary glands of pubertal mice fed a high-fat diet. Nutrition and Metabolic Insights. 16:1-10. https://doi.org/10.1177/11786388221148858.Consumption of a high-fat diet alters transcriptional rhythmicity in liver from pube pubertal mice-(Peer Reviewed Journal) Yan, L., Sundaram, S., Rust, B., Daniel, P., Luann, J., Zeng, H. 2023. Consumption of a high-fat diet alters transcriptional rhythmicity in liver from pube pubertal mice. Frontiers in Nutrition. 9. Article 1068350. https://doi.org/10.3389/fnut.2022.1068350.Alteration in plasma metabolome in high-fat diet-fed monocyte chemotactic protein-1 knockout mice bearing pulmonary metastasis of Lewis lung carcinoma-(Peer Reviewed Journal) Yan, L., Rust, B.M., Sundaram, S., Picklo, M.J., Bukowski, M.R. 2022. Alteration in plasma metabolome in high-fat diet-fed monocyte chemotactic protein-1 knockout mice bearing pulmonary metastasis of Lewis lung carcinoma. Nutrition and Metabolic Insights. 107. Article 109051. https://doi.org/10.1016/j.jnutbio.2022.109051.Metabolomes of Lewis lung carcinoma metastases and normal lung tissue from mice fed different diets-(Peer Reviewed Journal) Yan, L., Sundaram, S., Rust, B., Picklo, M.J., Bukowski, M.R. 2022. Metabolomes of Lewis lung carcinoma metastases and normal lung tissue from mice fed different diets. Journal of Nutritional Biochemistry. 107. Article 109051. https://doi.org/10.1016/j.jnutbio.2022.109051.Mammary tumorigenesis and metabolome in adipose specific monocyte chemotactic protein-1 deficient male MMTV-PyMT mice fed a high-fat diet-(Peer Reviewed Journal) Yan, L., Sundaram, S., Rust, B.M., Picklo, M.J., Bukowski, M.R. 2021. Mammary tumorigenesis and metabolome in adipose specific monocyte chemotactic protein-1 deficient male MMTV-PyMT mice fed a high-fat diet. Frontiers in Oncology. 11. Article 667843. https://doi.org/10.3389/fonc.2021.667843.Voluntary running of defined distances alters bone microstructure in C57BL6 mice fed a high-fat diet-(Peer Reviewed Journal) Yan, L., Nielsen, F.H., Sundaram, S., Cao, J.J. 2021. Voluntary running of defined distances alters bone microstructure in C57BL6 mice fed a high-fat diet. Applied Physiology, Nutrition & Metabolism. 46(11):1337-1344. https://doi.org/10.1139/apnm-2021-0061.Time-restricted feeding mice a high-fat diet induces a unique lipidomic profile-(Peer Reviewed Journal) Mehus, A.A., Rust, B.M., Idso, J.P., Hanson, B.K., Zeng, H., Yan, L., Bukowski, M.R., Picklo, M.J. 2020. Time-restricted feeding mice a high-fat diet induces a unique lipidomic profile. Journal of Nutritional Biochemistry. 88. Article 108531. https://doi.org/10.1016/j.jnutbio.2020.108531.The Metabolome of Mammary Tumors Differs from Normal Mammary Glands but Is not Altered by Time-restricted Feeding under Obesogenic Conditions-(Peer Reviewed Journal) Yan, L., Sundaram, S., Rust, B.M., Picklo, M.J., Bukowski, M.R. 2020. The metabolome of mammary tumors differs from normal mammary glands but is not altered by time-restricted feeding under obesogenic conditions. Anticancer Research. https://doi.org/10.21873/anticanres.14358.High-fat diet disrupts diurnal expression of circadian genes in mammary glands of prepubertal mice-(Peer Reviewed Journal) Sundaram, S., Johnson, L., Yan, L. 2020. High-fat diet disrupts diurnal expression of circadian genes in mammary glands of prepubertal mice. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2020.00349.Plasma metabolomic changes in mice with time-restricted feeding-attenuated spontaneous metastasis of Lewis lung carcinoma-(Peer Reviewed Journal) Yan, L., Rust, B.M., Picklo, M.J. 2020. Plasma metabolomic changes in mice with time-restricted feeding-attenuated spontaneous metastasis of Lewis lung carcinoma. Anticancer Research. https://doi.org/10.21873/anticanres.14137.Adipose monocyte chemotactic protein–1 deficiency reduces high-fat diet-enhanced mammary tumorigenesis in MMTV-PyMT mice-(Peer Reviewed Journal) Sundaram, S., Yan, L. 2019. Adipose monocyte chemotactic protein–1 deficiency reduces high-fat diet-enhanced mammary tumorigenesis in MMTV-PyMT mice. Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2019.108313.Dietary selenium supplementation does not attenuate mammary tumorigenesis-mediated bone loss in male MMTV-PyMT mice-(Peer Reviewed Journal) Yan, L., Nielsen, F., Sundaram, S., Cao, J.J. 2019. Dietary selenium supplementation does not attenuate mammary tumorigenesis-mediated bone loss in male MMTV-PyMT mice. Biological Trace Element Research. https://doi.org/10.1007/s12011-019-01767-7.Time-restricted feeding attenuates high-fat diet-enhanced spontaneous metastasis of Lewis lung carcinoma in mice-(Peer Reviewed Journal) Yan, L., Sundaram, S., Mehus, A.A., Picklo, M.J. 2019. Time-restricted feeding attenuates high-fat diet-enhanced spontaneous metastasis of Lewis lung carcinoma in mice. Anticancer Research. https://doi.org/10.21873/anticanres.13280.Adipose-specific monocyte chemotactic protein-1 deficiency reduces pulmonary metastasis of Lewis lung carcinoma in mice-(Peer Reviewed Journal) Yan, L., Sundaram, S. 2019. Adipose-specific monocyte chemotactic protein-1 deficiency reduces pulmonary metastasis of Lewis lung carcinoma in mice. Anticancer Research. https://doi.org/10.21873/anticanres.13279.Time-restricted feeding mitigates high-fat diet-enhanced mammary tumorigenesis in MMTV-PyMT mice-(Peer Reviewed Journal) Sundaram, S., Yan, L. 2018. Time-restricted feeding mitigates high-fat diet-enhanced mammary tumorigenesis in MMTV-PyMT mice. Nutrition Research. http://doi.org/10.1016/j.nutres.2018.07.014.A high-sucrose diet does not enhance spontaneous metastasis of Lewis lung carcinoma in mice-(Peer Reviewed Journal) Yan, L., Sundaram, S. 2018. A high-sucrose diet does not enhance spontaneous metastasis of Lewis lung carcinoma in mice. Nutrition Research. https://doi.org/10.1016/j.nutres.2018.07.001.Lipidomic impacts of an obesogenic diet upon Lewis lung carcinoma in mice-(Peer Reviewed Journal) Sundaram, S., Zacek, P., Bukowski, M.R., Mehus, A.A., Yan, L., Picklo, M.J. 2018. Lipidomic impacts of an obesogenic diet upon Lewis lung carcinoma in mice. Frontiers in Oncology. 8:134. https://doi.org/10.3389/fonc.2018.00134.Paternal exercise protects mouse offspring from high-fat-diet-induced type 2 diabetes risk by increasing skeletal muscle insulin signaling-(Peer Reviewed Journal) Krout, D.P., Roemmich, J.N., Garcia, R.A., Bundy, A.N., Yan, L., Larson, K.J. 2018. Paternal exercise protects mouse offspring from high-fat-diet-induced type 2 diabetes risk by increasing skeletal muscle insulin signaling. Journal of Nutritional Biochemistry. 57:35-44. https://doi.org/10.1016/j.jnutbio.2018.03.013.Changes in body adiposity and its associated inflammation affect metastasis of Lewis lung carcinoma in mice-(Abstract Only) Yan, L., Sundaram, S. 2017. Changes in body adiposity and its associated inflammation affect metastasis of Lewis lung carcinoma in mice [abstract]. Journal of Federation of American Societies for Experimental Biology. 31:435.6.Dietary supplementation with methylseleninic acid inhibits mammary tumorigenesis and metastasis in male MMTV-PyMT mice-(Peer Reviewed Journal) Sundaram, S., Yan, L. 2017. Dietary supplementation with methylseleninic acid inhibits mammary tumorigenesis and metastasis in male MMTV-PyMT mice. Biological Trace Element Research. https://doi.org/10.1007/s12011-017-1188-7.Voluntary running of defined distances reduces body adiposity and its associated inflammation in C57BL/6 mice fed a high-fat diet-(Peer Reviewed Journal) Yan, L., Sundaram, S. 2017. Voluntary running of defined distances reduces body adiposity and its associated inflammation in C57BL/6 mice fed a high-fat diet. Applied Physiology, Nutrition & Metabolism. http://dx.doi.org/10.1139/apnm-2017-0285.Monocyte chemotactic protein-1 attenuates and high-fat diet exacerbates bone loss in mice with pulmonary metastasis of Lewis lung carcinoma-(Peer Reviewed Journal) Yan, L., Nielsen, F.H., Sundaram, S., Cao, J.J. 2017. Monocyte chemotactic protein-1 attenuates and high-fat diet exacerbates bone loss in mice with pulmonary metastasis of Lewis lung carcinoma. Oncotarget. doi:10.18632/oncotarget.15055.Mammary tumorigenesis causes bone loss and dietary selenium supplementation does not affect such bone loss in male MMTV-PyMT mice-(Abstract Only) Yan, L., Sundaram, S. 2017. Mammary tumorigenesis causes bone loss and dietary selenium supplementation does not affect such bone loss in male MMTV-PyMT mice [abstract]. American Association of Cancer Research. 58:65.Effects of voluntary running with defined distances on body adiposity and its associated inflammation in mice fed a high-fat diet-(Abstract Only) Yan, L., Sundaram, S. 2017. Effects of voluntary running with defined distances on body adiposity and its associated inflammation in mice fed a high-fat diet [abstract]. Federation of American Societies for Experimental Biology Conference. 31:794.7.Dietary supplementation with methylseleninic acid reduces male mammary tumorigenesis in MMTV-PyMT mice-(Abstract Only) Sundaram, S., Yan, L. 2017. Dietary supplementation with methylseleninic acid reduces male mammary tumorigenesis in MMTV-PyMT mice [abstract]. American Association of Cancer Research. 58:64.High-fat diet enhances mammary tumorigenesis and pulmonary metastasis and alters inflammatory and angiogenic profiles in MMTV-PyMT mice-(Peer Reviewed Journal) Sundaram, S., Yan, L. 2016. High-fat diet enhances mammary tumorigenesis and pulmonary metastasis and alters inflammatory and angiogenic profiles in MMTV-PyMT mice. Anticancer Research. 36(12):6279-6288.High-fat diet enhances and monocyte chemoattractant protein-1 deficiency reduces bone loss in mice with pulmonary metastases of Lewis lung carcinoma-(Abstract Only) Sundaram, S., Yan, L. 2016. High-fat diet enhances and monocyte chemoattractant protein-1 deficiency reduces bone loss in mice with pulmonary metastases of Lewis lung carcinoma [abstract]. 2016 Annual Meeting of the American Association of Cancer Research, New Orleans, Louisiana, April 16-20, 2016. 76(14):4325.Dietary energy restriction reduces high-fat diet-enhanced metastasis of Lewis lung carcinoma in mice-(Peer Reviewed Journal) Sundaram, S., Yan, L. 2016. Dietary energy restriction reduces high-fat diet-enhanced metastasis of Lewis lung carcinoma in mice. Oncotarget. 7:65669-65675. doi:10.18632/oncotarget.11598.Effect of irrigation, intercrop and cultivar on agronomic and nutritional characteristics of quinoa-(Peer Reviewed Journal) Walters, H., Carpenter-Boggs, L., Desta, K., Yan, L., Matanguihan, J., Murphy, K. 2016. Effect of irrigation, intercrop and cultivar on agronomic and nutritional characteristics of quinoa. Agroecology and Sustainable Food Systems. 40(8):783-803.Monocyte chemotactic protein-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma in mice fed a high-fat diet-(Peer Reviewed Journal) Yan, L., Sundaram, S. 2016. Monocyte chemotactic protein-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma in mice fed a high-fat diet. Oncotarget. 7(17):24792-24799.Time-restricted feeding reduces adiposity in mice fed a high-fat diet-(Peer Reviewed Journal) Sundaram, S., Yan, L. 2016. Time-restricted feeding reduces adiposity in mice fed a high-fat diet. Nutrition Research. 36(6):603-611.Status of selenium in cancer prevention-(Book / Chapter) Combs, Jr., G.F., Yan, L. 2016. Status of selenium in cancer prevention. In: Hatfield, D.L., Berry, M.J., Gladyshev, V.N., editors. Selenium: Its Molecular Biology and Role in Human Health. Edition 4. New York, New York. Springer-Verlag. p. 321-332.  doi:10.1007/978-3-319-41283-2.Restricted feeding of a high-fat diet reduces spontaneous metastases of Lewis lung carcinoma in C57BL/6 mice-(Abstract Only) Yan, L., Sundaram, S. 2016. Restricted feeding of a high-fat diet reduces spontaneous metastases of Lewis lung carcinoma in C57BL/6 mice [abstract]. Federation of American Societies for Experimental Biology Conference, April 1-6, 2016, San Diego, California. 30:1167.10.Time-restricted feeding of a high-fat diet reduces adiposity and inflammatory cytokine production in mice-(Abstract Only) Sundaram, S., Yan, L. 2016. Time-restricted feeding of a high-fat diet reduces adiposity and inflammatory cytokine production in mice [abstract]. Federation of American Societies for Experimental Biology Conference, April 1-6, 2016, San Diego, California. 30:915.31.High-fat diets containing different amounts of n-3 polyunsaturated acids modulate adipokine production in mice-(Peer Reviewed Journal) Sundaram, S., Bukowski, M.R., Lie, W., Picklo, M.J., Yan, L. 2016. High-fat diets containing different amounts of n-3 polyunsaturated acids modulate adipokine production in mice. Lipids. 51(5):571-582.High-fat diet enhances and plasminogen activator inhibitor-1 deficiency attenuates bone loss in mice with Lewis Lung carcinoma-(Peer Reviewed Journal) Yan, L., Nielsen, F.H., Sundaram, S., Cao, J.J. 2015. High-fat diet enhances and plasminogen activator inhibitor-1 deficiency attenuates bone loss in mice with Lewis Lung carcinoma. Anticancer Research. 35(7):3839-3847.Time-restricted feeding of a high-fat diet reduces diet-induced obesity-(Abstract Only) Sundaram, S., Yan, L. 2015. Time-restricted feeding of a high-fat diet reduces diet-induced obesity [abstract]. Canadian Nutrition Society, Lipid Nutrition and Metabolism in Human Health Workshop Proceedings. 28.Effects of high-fat diets composed of different oils on adipokine production in mice-(Abstract Only) Sundaram, S., Bukowski, M.R., Picklo, M.J., Yan, L. 2015. Effects of high-fat diets composed of different oils on adipokine production in mice. Workshop Proceedings. 27.Soy protein is beneficial but high-fat diet and voluntary running are detrimental to bone structure in mice-(Peer Reviewed Journal) Yan, L., Graef, G.L., Nielsen, F.H., Johnson, L.K., Cao, J.J. 2015. Soy protein is beneficial but high-fat diet and voluntary running are detrimental to bone structure in mice. Nutrition Research. 35(6):523-531.Effects of Lewis lung carcinoma on trabecular microstructural changes in wild-type and plasminogen activator inhibitor-1 deficient mice fed a high-fat diet-(Abstract Only) Yan, L. 2015. Effects of Lewis lung carcinoma on trabecular microstructural changes in wild-type and plasminogen activator inhibitor-1 deficient mice fed a high-fat diet [abstract]. Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; April 18-22, 2015; Philadelphia, PA. Philadelphia (PA). Abstract number 890.Adipokine production in mice fed high-fat diets containing different types of dietary fats-(Abstract Only) Yan, L., Wen-Rong 2015. Adipokine production in mice fed high-fat diets containing different types of dietary fats [abstract]. Federation of American Societies for Experimental Biology Conference. 29:598.2.Effects of a high-fat diet on spontaneous metastasis of Lewis lung carcinoma in plasminogen activator inhibitor-1 deficient and wild-type mice-(Peer Reviewed Journal) Yan, L., Demars, L.C. 2014. Effects of a high-fat diet on spontaneous metastasis of Lewis lung carcinoma in plasminogen activator inhibitor-1 deficient and wild-type mice. PLoS One. 9(10):e110869.Consumption of a high-fat diet abrogates inhibitory effects of methylseleninic acid on spontaneous metastasis of Lewis lung carcinoma in mice-(Peer Reviewed Journal) Yan, L., Combs, G.F. 2014. Consumption of a high-fat diet abrogates inhibitory effects of methylseleninic acid on spontaneous metastasis of Lewis lung carcinoma in mice. Carcinogenesis. 35(10):2308-2313.Effects of voluntary running and soy supplementation on diet-induced metabolic disturbances and inflammation in mice-(Peer Reviewed Journal) Yan, L., Graef, G.L., Claycombe, K.J., Johnson, L.K. 2013. Effects of voluntary running and soy supplementation on diet-induced metabolic disturbances and inflammation in mice. Journal of Agricultural and Food Chemistry. 61:9373-9379.Curcumin reduces trabecular and cortical bone in naive and Lewis lung carcinoma-bearing mice-(Peer Reviewed Journal) Yan, L., Yee, J.A., Cao, J.J. 2013. Curcumin reduces trabecular and cortical bone in naive and Lewis lung carcinoma-bearing mice. Anticancer Research. 33:3153-3162.Fatty liver accompanies an increase in Lactobacillus species in the hind gut of C57BL/6 mice fed a high-fat diet-(Peer Reviewed Journal) Zeng, H., Liu, J., Jackson, M.I., Zhao, F., Yan, L., Combs, G.F. 2013. Fatty liver accompanies an increase in Lactobacillus species in the hind gut of C57BL/6 mice fed a high-fat diet. Journal of Nutrition. doi:10.3945/jn.112.172460.Quantitative protein profiling of tumor angiogenesis and metastasis biomarkers in mouse and human models-(Abstract Only) Lie, W., Lipsey, J., Warmke, T., Yan, L., Mistry, J. 2014. Quantitative profiling of angiogenesis and metastasis protein biomarkers in mouse and human models. American Association of Cancer Research Meeting. [abstract] In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; April 5-9, 2014; San Diego, CA. Philadelphia (PA); AACR; Cancer Prev Res 2014;74(19Suppl): Abstract no 3995.Curcumin deteriorates trabecular and cortical bone in mice bearing metastatic Lewis lung carcinoma-(Abstract Only) Yan, L. 2013. Curcumin deteriorates trabecular and cortical bone in mice bearing metastatic Lewis lung carcinoma. American Association of Cancer Research Meeting. [abstract] In: Proceedings of the AACR Special Conference on tumor Invasion and Metastasos; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA); AACR; Cancer Prev Res 2013;73(3 Suppl): Abstract no B77.Fatty liver accompanies an increase of Lactobacillus acidophilus in the hind gut of C57/BL mice fed a high-fat diet-(Abstract Only) Zeng, H., Liu, J., Jackson, M.I., Yan, L., Combs, G.F. 2013. Fatty liver accompanies an increase of Lactobacillus acidophilus in the hind gut of C57/BL mice fed a high-fat diet. Federation of American Societies for Experimental Biology Conference. 27:1067.4.Dietary supplementation with curcumin enhances metastatic growth of Lewis lung carcinoma in mice-(Abstract Only) Yan, L. 2012. Dietary supplementation with curcumin enhances metastatic growth of Lewis lung carcinoma in mice. American Association of Cancer Research. [abstract] In: Proceedings of the Eleventh Annual AACR International Conference on Frontiers in Cancer Research; October 16-19, 2012; Anaheim, CA. Philadelphia (PA); AACR; Cancer Prev Res 2012;5(11Suppl): Abstract no A39.Dietary supplementation with curcumin enhances metastatic growth of Lewis lung carcinoma in mice-(Peer Reviewed Journal) Yan, L. 2012. Dietary supplementation with curcumin enhances metastatic growth of Lewis lung carcinoma in mice. International Journal of Cancer. 132:269-275.Long-term voluntary running improves diet-induced adiposity in young adult mice-(Peer Reviewed Journal) Yan, L., Demars, L.C., Johnson, L.K. 2012. Long-term voluntary running improves diet-induced adiposity in young adult mice. Nutrition Research. 32:458-465.Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice-(Abstract Only) Yan, L., Demars, L.C. 2012. Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice. Federation of American Societies for Experimental Biology Conference. 26:376.2.Non-motorized voluntary running does not affect experimental and spontaneous metastasis in mice-(Abstract Only) Yan L, DeMars LC.  Non-motorized voluntary running does not affect experimental and spontaneous metastasis in mice.  Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 March 31-April 4; Chicago, IL. Philadelphia (PA): AACR; 2012; 2012. Abst nr 595.Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice-(Peer Reviewed Journal) Yan, L., Demars, L.C. 2012. Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice. International Journal of Cancer. 131:1260-1266.Effects of non-motorized voluntary running on experimental and spontaneous metastasis in mice-(Peer Reviewed Journal) Yan, L., Demars, L.C. 2011. Effects of non-motorized voluntary running on experimental and spontaneous metastasis in mice. Anticancer Research. 31:3337-3344.Genotype × Environment interactions for mineral concentration in grain of organically grown spring wheat-(Peer Reviewed Journal) Murphy, K.M., Hoagland, L.A., Yan, L., Colley, M., Jones, S.S. 2011. Genotype × Environment interactions for mineral concentration in grain of organically grown spring wheat. Agronomy Journal. 103:1734–1741.Selenium bioavailability from naturally produced high-selenium peas and oats in selenium-deficient rats-(Peer Reviewed Journal) Yan, L., Johnson, L.K. 2011. Selenium bioavailability from naturally produced high-selenium peas and oats in selenium-deficient rats. Journal of Agricultural and Food Chemistry. 59:6305-6311.Dietary selenomethionine intake increases exon-specific DNA methylation of p53 gene in rat liver and colon mucosa-(Peer Reviewed Journal) Zeng, H., Yan, L., Cheng, W., Uthus, E.O. 2011. Dietary selenomethionine intake increases exon-specific DNA methylation of p53 gene in rat liver and colon mucosa. Journal of Nutrition. 141(8):1464-1468.Effects of the physical form of the diet on food intake, growth, and body composition changes in mice-(Peer Reviewed Journal) Yan, L., Combs, G.F., Demars, L.C., Johnson, L.K. 2011. Effects of the physical form of the diet on food intake, growth, and body composition changes in mice. Journal of the American Association for Laboratory Animal Science. 50(4):488-494.Effects of diet-induced obesity on secondary tumor development and plasma cytokine expression in mice-(Abstract Only) Yan, L., Demars, L.C. 2011. Effects of diet-induced obesity on secondary tumor development and plasma cytokine expression in mice. Federation of American Societies for Experimental Biology Conference. 25:977.11Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice-(Peer Reviewed Journal) Yan, L., Demars, L.C. 2010. Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice. Clinical and Experimental Metastasis. 27(8):581-590.Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma and changes in plasma cytokine concentrations in mice-(Abstract Only) Yan, L. 2010. Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma and changes in plasma cytokine concentrations in mice. American Association of Cancer Research Meeting. Abstract No.B41 p.107.Assessment of selenium bioavailability from naturally produced high-selenium soy foods in selenium-deficient rats-(Peer Reviewed Journal) Yan, L., Reeves, P.G., Johnson, L.K. 2010. Assessment of selenium bioavailablity from naturally produced high-selenium soy foods in selenium-deficient rats. Journal of Trace Elements in Medicine and Biology. 24:223-229.Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis-(Abstract Only) Yan, L., Spitznagel, E.L., Bosland, M.C. 2010. Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis. Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington DC. Philadelphia (PA): AACR; 2010; 2010. Abst nr. 1893.Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis-(Peer Reviewed Journal) Yan, L., Spitznaagel, E.L., Bosland, M.C. 2010. Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis. Cancer Epidemiology Biomarkers and Prevention. 19(1):148-158.Selenium Bioavailability from Soy Protein Isolate and Tofu in Rats Fed a Torula Yeast-Based Diet-(Peer Reviewed Journal) Yan, L., Graef, G.L., Reeves, P.G., Johnson, L.K. 2009. Selenium Bioavailability from Soy Protein Isolate and Tofu in Rats Fed a Torula Yeast-Based Diet. Journal of Agriculture and Food Chemistry. 57:11575-11580.Soy Consumption and Prostate Cancer Risk in Men: A Revisit of Meta-Analysis-(Peer Reviewed Journal) Yan, L., Spitznagel, E.L. 2009. Soy Consumption and Prostate Cancer Risk in Men: A Revisit of Meta-Analysis. American Journal of Clinical Nutrition.89:1155-1163.Soy, Isoflavones, and Prostate Cancer Risk in Men: A Revisit of Meta-Analysis-(Abstract Only) Yan, L., Spitznagel, E.L. 2009. Soy, Isoflavones, and Prostate Cancer Risk in Men: A Revisit of Meta-Analysis. Journal of American Societies for Experimental Biology. 23:298.1.Selenium Bioavailability from Soybeans in Rats Fed a Modified Torula Yeast Diet-(Abstract Only) Yan, L., Graef, G.L., Reeves, P.G., Johnson, L.K. 2009. Selenium Bioavailability from Soybeans in Rats Fed a Modified Torula Yeast Diet. Journal of Federation of American Societies for Experimental Biology.       23:728.1.Soy Consumption of Prostate Cancer Risk in Men: A Meta-Analysis-(Abstract Only) Yan, L., Spitznagel, E.L. 2008. Soy Consumption of Prostate Cancer Risk in Men: A Meta-Analysis. American Institute for Cancer Research Conference. Abstract will not be published.
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