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ARS Home Pacific West Area Davis, California Western Human Nutrition Research Center Obesity and Metabolism Research People





John William Newman    Research Chemist **RESEARCH SCIENTIST**
430 West Health Sciences Drive
University of California, Davis
Davis, CA 95616

Phone:(530) 752-1009
/ARSUserFiles/37206/Newman/Research Team/2.jpg   **NEWMAN LAB**
 Biography
                              Dr. John Newman is an avid collaborator with researchers in the WHNRC, the U.S., and abroad who brings expertise in analytical biochemistry, state-of-the-art analytical instrumentation and the use of metabolomics to the WHNRC.  Dr. Newman is applying these tools to determine the impact of diet and dietary components on human health, with a special emphasis given to the obesity problem, its complications associated with the high fat "Western" diet and the variability in individual responses to dietary factors.

Dr. Newman is a California native who has received higher education in Colorado and California.  He obtained a baccalaureate degree in biochemistry and molecular biology from the University of California Santa Cruz in 1991, worked extensively in the field of environmental analytical chemistry until 1996, obtained a Ph.D. in pharmacology and toxicology from the University of California, Davis in 2002, and worked as a Research Associate at UC Davis until 2005 exploring the biomedical applications of eicosanoid metabolic profiling. He has extensive experience in trace organic quantitative chemistry,  data quality assessment and quality control, analytical method development, as well as modest skills in chemical synthesis and technical experience with a range of state-of-the-art analytical instrumentation: NMR spectroscopy (1H, 13C, 15N, 19F); gas and liquid chromatographic systems (GC, GPC/SEC, FPLC, GPLC, UPLC); gel electrophoresis; mass spectroscopy (MALDI-TOF-MS, API-TOF-MS, API-MS, API/MS/MS).  He has applied spectroscopic analysis to support structural confirmation of synthetic products, structural elucidation of unknown products, identification of protein modification, and quantitation of both exogenous and endogenous molecules isolated from an array of biological matrices.  Dr. Newman has focused these efforts on the development and application of analytical tools to profile a broad range of lipids with important roles in the regulation of inflammation, vascular and renal function, and cellular growth.

Investigations surrounding the endogenous role of the soluble epoxide hydrolase were at the root of these investigations. They have since expanded to encompass products of the major lipid oxygenases including prostanoids and various eicosanoids as well as analogous materials generated for eighteen and twenty-two carbon lipids.  These analytical profiling efforts have more recently broadened to investigate other bioactive lipid mediators involved in the regulation of energy balance and body mass, including a suite of endocannabinoids.  The role of these regulatory pathways have been explored in inflammation, renal function, vascular regulation and disease, blood pressure regulation and both male and female reproductive physiology.  More recently, these tools have been turned on the lipoprotein particle, and subtle structural changes in these particles are beginning to be observed.

During his research career, Dr. Newman has written or supported more than 150 articles in peer-reviewed journals.  He has served as a peer reviewer for an array of journals including the American Journal of Clinical Nutrition, the British Journal of Nutrition, the Journal of Chromatography, Archives in Biochemistry and Biophysics, Chemosphere, Proteomics, and Metabolomics.  In addition, Dr. Newman is a member in good standing in the Metabolomics Society and the American Chemical Society.
 Publications(Clicking on the reprint iconReprint Icon  will take you to the publication reprint.)Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders-(Literature Review) Liang, N., Harsch, B.A., Zhou, S., Borkowska, A.G., Shearer, G.C., Kaddurah-Daouk, R., Newman, J.W., Borkowski, K. 2023. Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders. Progress in Lipid Research. 93. Article 101265. https://doi.org/10.1016/j.plipres.2023.101265.Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans-(Peer Reviewed Journal) U-Din, M., De Mello, V.D., Tuomainen, M., Raiko, J., Niemi, T., Fromme, T., Klavus, A., Gautier, N., Haimilahti, K., Lehtonen, M., Kristiansen, K., Newman, J.W., Pietiläinen, K.H., Pihlajamäki, J., Amri, E., Klingenspor, M., Nuutila, P., Pirinen, E., Hanhineva, K., Virtanen, K.A. 2023. Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans. Cell Reports. 42(9). https://doi.org/10.1016/j.celrep.2023.113131.Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism-(Peer Reviewed Journal) Borkowski, K., Seyfried, N.T., Arnold, M., Lah, J.J., Levey, A.I., Hales, C.M., Dammer, E.B., Blach, C., Louie, G., Kaddurah-Daouk, R., Newman, J.W. 2023. Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism. Scientific Reports. 13. Article 13752. https://doi.org/10.1038/s41598-023-39737-8.Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis-(Peer Reviewed Journal) Mukherjee, A., Bezwada, D., Greco, F., Zandbergen, M., Shen, T., Chiang, C., Tasdemir, M., Fahrmann, J., Grapov, D., La Frano, M.R., Vu, H.S., Faubert, B., Newman, J.W., Mcdonnell, L.A., Nezi, L., Fiehn, O., Deberardinis, R., Lengyel, E. 2023. Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis. Cell Metabolism. https://doi.org/10.1038/s42255-023-00879-8.Tai Chi exercise reduces circulating levels of inflammatory oxylipins in postmenopausal women with knee osteoarthritis: results from a pilot study-(Peer Reviewed Journal) Shen, C., Newman, J.W., Elmassry, M.M., Borkowski, K., Chyu, M., Kahathuduwa, C., Neugebauer, V., Watkins, B.A. 2023. Tai Chi exercise reduces circulating levels of inflammatory oxylipins in postmenopausal women with knee osteoarthritis: results from a pilot study. Frontiers in Medicine. 10. https://doi.org/10.3389/fmed.2023.1210170.The impacts of slc19a3 deletion and intestinal SLC19A3 insertion on thiamine distribution and brain metabolism in the mouse-(Peer Reviewed Journal) Wen, A., Zhu, Y., Yee, S., Park, B., Giacomini, K.M., Greenberg, A.S., Newman, J.W. 2023. The impacts of slc19a3 deletion and intestinal SLC19A3 insertion on thiamine distribution and brain metabolism in the mouse. Metabolites. https://doi.org/10.3390/metabo13080885.Dietary docosahexaenoic acid and glucose systemic metabolic changes in the mouse-(Peer Reviewed Journal) Watkins, B., Newman, J.W., Kuchel, G.A., Fiehn, O., Kim, J. 2023. Dietary docosahexaenoic acid and glucose systemic metabolic changes in the mouse. Nutrients. 15(12). Article 2679. https://doi.org/10.3390/nu15122679.The effect of trimethoprim on thiamine absorption: A transporter-mediated drug-nutrient interaction-(Peer Reviewed Journal) Vora, B., Wen, A., Yee, S., Trinh, K., Azimi, M., Green, E.A., Sirota, M., Greenberg, A.S., Newman, J.W., Giacomini, K.M. 2023. The effect of trimethoprim on thiamine absorption: A transporter-mediated drug-nutrient interaction. Clinical Pharmacology and Therapeutics. 114(2):381-392. https://doi.org/10.1002/cpt.2932.Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis-(Peer Reviewed Journal) Virupakshaiah, A., Ladakis, D., Nourbakhsh, B., Bhargava, P., Dilwali, S., Schoeps, V., Borkowski, K., Newman, J.W., Waubant, E. 2023. Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis. Multiple Sclerosis Journal. 29(8). https://doi.org/10.1177/13524585231171517.Effects of a genetic variant rs13266634 in the zinc transporter 8 gene (SLC30A8) on insulin and lipid levels before and after a high-fat mixed macronutrient tolerance test in U.S. adults-(Peer Reviewed Journal) Yang, Z., Wang, Y.E., Kirschke-Schneide, C.P., Stephensen, C.B., Newman, J.W., Keim, N.L., Cai, Y., Huang, L. 2023. Effects of a genetic variant rs13266634 in the zinc transporter 8 gene (SLC30A8) on insulin and lipid levels before and after a high-fat mixed macronutrient tolerance test in U.S. adults. Journal of Trace Elements in Medicine and Biology. 77. Article 127142. https://doi.org/10.1016/j.jtemb.2023.127142.Prospective placebo-controlled assessment of spore-based probiotic supplementation on sebum production, skin barrier function, and acne-(Peer Reviewed Journal) Rybak, I., Haas, K., Dhaliwal, S., Burney, W., Pourang, A., Sandhu, S.S., Maloh, J., Newman, J.W., Crawford, R., Sivamani, R.K. 2023. Prospective placebo-controlled assessment of spore-based probiotic supplementation on sebum production, skin barrier function, and acne. Journal of Clinical Medicine. 12(3). Article 895. https://doi.org/10.3390/jcm12030895.Trimethylamine N-Oxide response to a mixed macronutrient tolerance test in a cohort of United States adults-(Peer Reviewed Journal) James, K.L., Gertz, E.R., Kirschke-Schneide, C.P., Allayee, H., Huang, L., Kable, M.E., Newman, J.W., Stephensen, C.B., Bennett, B.J. 2023. Trimethylamine N-Oxide response to a mixed macronutrient tolerance test in a cohort of United States adults. International Journal of Molecular Sciences. 24(3). Article 2074. https://doi.org/10.3390/ijms24032074.Editorial: Postprandial physiology-(Other) Fiamonici, J., Newman, J.W., Brennan, L. 2022. Editorial: Postprandial physiology. Frontiers in Nutrition. 9. https://doi.org/10.3389/fnut.2022.1107480.Metabolite patterns associated with individual response to supervised exercise therapy in patients with intermittent claudication-(Peer Reviewed Journal) Bellomo, T.R., Tsao, N.L., Johnston-Cox, H., Borkowski, K., Shakt, G., Judy, R., Moore, J., Ratcliffe, S., Fiehn, O., Floyd, T.F., Wehrli, F.W., Mohler, E., Newman, J.W., Damrauer, S.M. 2022. Metabolite patterns associated with individual response to supervised exercise therapy in patients with intermittent claudication. Journal of Vascular Science. 3:379-388. https://doi.org/10.1016/j.jvssci.2022.10.002.The plasma oxylipin signature provides a deep phenotyping of metabolic syndrome complementary to the clinical criteria-(Peer Reviewed Journal) Dalle, C., Tournayre, J., Mainka, M., Basiak-Rasala, A., Pétéra, M., Lefèvre-Arbogast, S., Dalloux-Chioccioli, J., Deschasaux-Tanguy, M., Lecuyer, L., Kesse-Guyot, E., Fezeu, L., Hercberg, S., Galan, P., Samieri, C., Zatonska, K., Calder, P.C., Hjorth, M., Astrup, A., Mazur, A., Bertand-Michel, J., Schebb, N.H., Szuba, A., Touvier, M., Newman, J.W., Gladine, C. 2022. The plasma oxylipin signature provides a deep phenotyping of metabolic syndrome complementary to the clinical criteria. International Journal of Molecular Sciences. 23(19). Article 11688. https://doi.org/10.3390/ijms231911688.Potential cardioprotective effects and lipid mediator differences in long-chain omega-3 polyunsaturated fatty acid supplemented mice given chemotherapy-(Peer Reviewed Journal) Angelotti, A., Snoke, D., Ormiston, K., Cole, R., Borkowski, K., Newman, J.W., Orchard, T., Belury, M.A. 2022. Potential cardioprotective effects and lipid mediator differences in long-chain omega-3 polyunsaturated fatty acid supplemented mice given chemotherapy. Metabolites. 12(9). Article 782. https://doi.org/10.3390/metabo12090782.SNPs in apolipoproteins contribute to sex-dependent differences in blood lipids before and after a high-fat dietary challenge in healthy U.S. adults-(Peer Reviewed Journal) Wang, Y.E., Kirschke-Schneide, C.P., Woodhouse, L.R., Bonnel, E.L., Stephensen, C.B., Bennett, B.J., Newman, J.W., Keim, N.L., Huang, L. 2022. SNPs in apolipoproteins contribute to sex-dependent differences in blood lipids before and after a high-fat dietary challenge in healthy U.S. adults. Biomed Central (BMC) Nutrition. 8. Article 95. https://doi.org/10.1186/s40795-022-00592-x.Associations of microbial and indoleamine-2,3-dioxygenase-derived tryptophan metabolites with immune activation in healthy adults-(Peer Reviewed Journal) Riazati, N., Kable, M.E., Newman, J.W., Adkins, Y.C., Freytag, T.L., Jiang, X., Stephensen, C.B. 2022. Associations of microbial and indoleamine-2,3-dioxygenase-derived tryptophan metabolites with immune activation in healthy adults. Frontiers in Immunology. 13. Article 917966. https://doi.org/10.3389/fimmu.2022.917966.Blood levels of endocannabinoids, oxylipins, and metabolites are altered in hemodialysis patients-(Peer Reviewed Journal) Watkins, B.A., Friedman, A.N., Kim, J., Borkowski, K., Kaiser, S., Fiehn, O., Newman, J.W. 2022. Blood levels of endocannabinoids, oxylipins, and metabolites are altered in hemodialysis patients. International Journal of Molecular Sciences. 23(17).  https://doi.org/10.3390/ijms23179781.Linoleate-rich safflower oil diet increases linoleate-derived bioactive lipid mediators in plasma, and brown and white adipose depots of healthy mice-(Peer Reviewed Journal) Snoke, D., Angelotti, A., Borkowski, K., Cole, R., Newman, J.W., Belury, M.A. 2022. Linoleate-rich safflower oil diet increases linoleate-derived bioactive lipid mediators in plasma, and brown and white adipose depots of healthy mice. Metabolites. 12(8). Article 743. https://doi.org/10.3390/metabo12080743.Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures-(Peer Reviewed Journal) Sotak, M., Rajan, M., Clark, M., Harms, M., Rani, A., Kraft, J.D., Tandio, D., Shen, T., Borkowski, K., Fiehn, O., Newman, J.W., Quiding-Jarbrink, M., Biorserud, C., Apelgren, P., Staalesen, T., Hagberg, C., Boucher, J., Wallenius, V., Lange, S., Borgeson, E. 2022. Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures. iScience. 25(7). Article 104602. https://doi.org/10.1016/j.isci.2022.104602.Association of microbial tryptophan metabolites and indoleamine-2,3-dioxygenase with immune activity in healthy adults-(Abstract Only) Riazati, N., Kable, M.E., Newman, J.W., Stephensen, C.B. 2022. Association of microbial tryptophan metabolites and indoleamine-2,3-dioxygenase with immune activity in healthy adults. Current Developments in Nutrition. 6/993. https://doi.org/10.1093/cdn/nzac068.022.Multiassay nutritional metabolomics profiling of low vitamin A status versus adequacy is characterized by reduced plasma lipid mediators among lactating women in the Philippines: A pilot study-(Peer Reviewed Journal) Johnson, C.M., Rosario, R., Brito, A., Agrawal, K., Fanter, R., Lietz, G., Haskell, M., Engle-Stone, R., Newman, J.W., La Frano, M.R. 2022. Multiassay nutritional metabolomics profiling of low vitamin A status versus adequacy is characterized by reduced plasma lipid mediators among lactating women in the Philippines: A pilot study. Nutrition Research. 104:118-127. https://doi.org/10.1016/j.nutres.2022.05.007.Assessing insulin sensitivity and postprandial triglyceridemic response phenotypes with a mixed macronutrient tolerance test-(Peer Reviewed Journal) Newman, J.W., Krishnan, S., Borkowski, K., Adams, S.H., Stephensen, C.B., Keim, N.L. 2022. Assessing insulin sensitivity and postprandial triglyceridemic response phenotypes with a mixed macronutrient tolerance test. Frontiers in Nutrition. 9. Article 877696. https://doi.org/10.3389/fnut.2022.877696.Plasma oxylipin profile discriminates ethnicities in subjects with non-alcoholic steatohepatitis: An exploratory analysis-(Peer Reviewed Journal) Mazi, T.A., Borkowski, K., Fiehn, O., Bowlus, C.L., Sarkar, S., Matsukuma, K., Ali, M.R., Kieffer, D.A., Wan, Y.Y., Stanhope, K.L., Havel, P.J., Newman, J.W., Medici, V. 2022. Plasma oxylipin profile discriminates ethnicities in subjects with non-alcoholic steatohepatitis: An exploratory analysis. Metabolites. 12(2). Article 192. https://doi.org/10.3390/metabo12020192.The omega-3 index response to an 8 week randomized intervention containing three fatty fish meals per week is influenced by adiposity in overweight to obese women-(Peer Reviewed Journal) Richardson, C.E., Krishnan, S., Gray, I.J., Keim, N.L., Newman, J.W. 2022. The omega-3 index response to an 8 week randomized intervention containing three fatty fish meals per week is influenced by adiposity in overweight to obese women. Frontiers in Nutrition. 9. Article 810003. https://doi.org/10.3389/fnut.2022.810003.Almond consumption for 8 weeks altered host and microbial metabolism in comparison to a control snack in young adults-(Peer Reviewed Journal) Dhillon, J., Newman, J.W., Fiehn, O., Ortiz, R.M. 2022. Almond consumption for 8 weeks altered host and microbial metabolism in comparison to a control snack in young adults. Journal of the American Nutrition Association. Article 2025168. https://doi.org/10.1080/07315724.2021.2025168.Non-invasive metabolomics biomarkers of production efficiency and beef carcass quality traits-(Peer Reviewed Journal) Artegoitia, V.M., Newman, J.W., Foote, A.P., Shackelford, S.D., King, D.A., Wheeler, T.L., Lewis, R.M., Freetly, H.C. 2022. Non-invasive metabolomics biomarkers of production efficiency and beef carcass quality traits. Scientific Reports. 12. Article 231. https://doi.org/10.1038/s41598-021-04049-2.Resistant starch wheat increases PYY and decreases GIP but has no effect on self-reported perceptions of satiety-(Peer Reviewed Journal) Hughes, R., Horn, W.F., Wen, A., Rust, B., Woodhouse, L.R., Newman, J.W., Keim, N.L. 2021. Resistant starch wheat increases PYY and decreases GIP but has no effect on self-reported perceptions of satiety. Appetite. 168. Article 105802. https://doi.org/10.1016/j.appet.2021.105802.Improving LC-MS analysis of human milk B-vitamins by lactose removal-(Peer Reviewed Journal) Hampel, D., Shahab-Ferdows, S., Newman, J.W., Allen, L.H. 2021. Improving LC-MS analysis of human milk B-vitamins by lactose removal. Journal of Chromatography B. 1183. Article 122968. https://doi.org/10.1016/j.jchromb.2021.122968.Effects of a diet based on the Dietary Guidelines on vascular health and TMAO in women with cardiometabolic risk factors-(Peer Reviewed Journal) Krishnan, S., Gertz, E.R., Adams, S.H., Newman, J.W., Pedersen, T.L., Keim, N.L., Bennett, B.J. 2021. Effects of a diet based on the Dietary Guidelines on vascular health and TMAO in women with cardiometabolic risk factors. Nutrition Metabolism and Cardiovascular Disease. 32(1):210-219. https://doi.org/10.1016/j.numecd.2021.09.013.Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification-(Peer Reviewed Journal) Borkowski, K., Taha, A.Y., Pedersen, T.L., De Jager, P.L., Bennett, D.A., Arnold, M., Kaddurah-Daouk, R., Newman, J.W. 2021. Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification. Scientific Reports. 11. Article 18964. https://doi.org/10.1038/s41598-021-98640-2.Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease-(Peer Reviewed Journal) Borkowski, K., Pedersen, T.L., Seyfried, N.T., Lah, J.J., Levey, A.I., Hales, C.M., Dammer, E.B., Blach, C., Louie, G., Kaddurah-Daouk, R., Newman, J.W. 2021. Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease. Alzheimer's Research & Therapy. 13. Article 149. https://doi.org/10.1186/s13195-021-00893-6.Genetic and environmental influences on serum oxylipins, endocannabinoids, bile acids and steroids-(Peer Reviewed Journal) Bermingham, K.M., Brennan, L., Segurado, R., Gray, I.J., Barron, R.E., Gibney, E.R., Ryan, M.F., Gibney, M.J., Newman, J.W., O'Sullivan, A.M. 2021. Genetic and environmental influences on serum oxylipins, endocannabinoids, bile acids and steroids. Prostaglandins Leukotrienes and Essential Fatty Acids. 173. Article 102338. https://doi.org/10.1016/j.plefa.2021.102338.Oxylipin responses to fasting and insulin infusion in a large mammalian model of fasting-induced insulin resistance, the northern elephant seal-(Peer Reviewed Journal) Wright, D.N., Katundu, K.G., Viscarra, J.A., Crocker, D.E., Newman, J.W., La Frano, M.R., Ortiz, R.M. 2021. Oxylipin responses to fasting and insulin infusion in a large mammalian model of fasting-induced insulin resistance, the northern elephant seal. American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 321(4):R537-R546. https://doi.org/10.1152/ajpregu.00016.2021.Host lipidome and tuberculosis treatment failure-(Peer Reviewed Journal) Shivakoti, R., Newman, J.W., Hanna, L.E., Queiroz, A.T., Borkowski, K., Gupte, A.N., Paradkar, M., Satyamurthi, P., Kulkarni, V., Selva, M., Pradhan, N., Shivakumar, S.V., Natarajan, S., Karunaianantham, R., Gupte, N., Thiruvengadam, K., Fiehn, O., Bharadwaj, R., Kagal, A., Gaikwad, S., Sangle, S., Golub, J.E., Andrade, B.B., Mave, V., Gupta, A., Padmapriyadarsini, C. 2022. Host lipidome and tuberculosis treatment failure. European Respiratory Journal. 59. Article 2004532. https://doi.org/10.1183/13993003.04532-2020.Healthy eating index patterns in adults by sex and age predict cardiometabolic risk factors in a cross-sectional study-(Peer Reviewed Journal) Artegoitia Etchev, V.M., Krishnan, S., Bonnel, E.L., Stephensen, C.B., Keim, N.L., Newman, J.W. 2021. Healthy eating index patterns in adults by sex and age predict cardiometabolic risk factors in a cross-sectional study. Biomed Central (BMC) Nutrition. 7. Article 30. https://doi.org/10.1186/s40795-021-00432-4.Ethnicity-specific alterations of plasma and hepatic lipidomic profiles are related to high NAFLD rate and severity in Hispanic Americans, a pilot study-(Peer Reviewed Journal) Mazi, T.A., Borkowski, K., Newman, J.W., Fiehn, O., Bowlus, C., Srkar, S., Matsukuma, K., Ali, M.R., Kieffer, D.A., Wan, Y.Y., Stanhope, K.L., Havel, P.J., Medici, V. 2021. Ethnicity-specific alterations of plasma and hepatic lipidomic profiles are related to high NAFLD rate and severity in Hispanic Americans, a pilot study. Free Radical Biology and Medicine. https://doi.org/10.1101/2021.04.08.21254907.Resistant starch type 2 from wheat reduces postprandial glycemic response with concurrent alterations in gut microbiota composition-(Peer Reviewed Journal) Hughes, R.L., Horn, W.F., Finnegan, P., Newman, J.W., Marco, M.L., Keim, N.L., Kable, M.E. 2021. Resistant starch type 2 from wheat reduces postprandial glycemic response with concurrent alterations in gut microbiota composition. Nutrients. 13(2):645. https://doi.org/10.3390/nu13020645.Gestational long-term hypoxia induces metabolomic reprogramming and phenotypic transformations in fetal sheep pulmonary arteries-(Peer Reviewed Journal) Leslie, E., Lopez, V., Anti, N., Alvarez, R., Kafeero, I., Welsh, D.G., Romero, M., Kaushal, S., Johnson, C.M., Bosviel, R., Blazenovic, I., Song, R., Brito, A., La Frano, M.R., Zhang, L., Newman, J.W., Fiehn, O., Wilson, S. 2021. Gestational long-term hypoxia induces metabolomic reprogramming and phenotypic transformations in fetal sheep pulmonary arteries. American Journal of Physiology - Lung Cellular and Molecular Physiology. 320(5):L770-L784. https://doi.org/10.1152/ajplung.00469.2020.Exogenous GLP-1 stimulates TCA cycle and suppresses gluconeogenesis and ketogenesis in late-fasted northern elephant seals pups-(Peer Reviewed Journal) Dhillon, J., Viscarra, J.A., Newman, J.W., Fiehn, O., Crocker, D.E., Ortiz, R.M. 2021. Exogenous GLP-1 stimulates TCA cycle and suppresses gluconeogenesis and ketogenesis in late-fasted northern elephant seals pups. American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 320(4):R393-R401. https://doi.org/10.1152/ajpregu.00211.2020.N-3 PUFA improved post-menopausal depression induced by maternal separation and chronic mild stress through serotonergic pathway in rats – effect associated with lipid mediators-(Peer Reviewed Journal) Choi, J., Borkowski, K., Newman, J.W., Park, Y. 2021. N-3 PUFA improved post-menopausal depression induced by maternal separation and chronic mild stress through serotonergic pathway in rats – effect associated with lipid mediators. Journal of Nutritional Biochemistry. 91. Article 108599. https://doi.org/10.1016/j.jnutbio.2021.108599.Plasma and serum oxylipin, endocannabinoid, bile acid, steroid, fatty acid and nonsteroidal anti-inflammatory drug quantification in a 96-well plate format-(Peer Reviewed Journal) Pedersen, T.L., Gray, I.J., Newman, J.W. 2020. Plasma and serum oxylipin, endocannabinoid, bile acid, steroid, fatty acid and nonsteroidal anti-inflammatory drug quantification in a 96-well plate format. Analytica Chimica Acta. 1143:189-200. https://doi.org/10.1016/j.aca.2020.11.019.Pre-analytical sample handling conditions and their effects on the human serum metabolome in epidemiologic studies-(Peer Reviewed Journal) McClain, K., Moore, S.C., Sampson, J.N., Henderson, T.R., Gebauer, S.K., Newman, J.W., Ross, S., Pedersen, T.L., Baer, D.J., Zanetti, K.A. 2021. Pre-analytical sample handling conditions and their effects on the human serum metabolome in epidemiologic studies. American Journal of Epidemiology. 190(3):459-467. https://doi.org/10.1093/aje/kwaa202.Mid-gestation serum lipidomic profile associations with spontaneous preterm birth are influenced by body mass index-(Peer Reviewed Journal) Borkowski, K., Newman, J.W., Aghaeepour, N., Mayo, J.A., Blazenovic, I., Fiehn, O., Stevenson, D.K., Shaw, G.M., Carmichael, S.L. 2020. Mid-gestation serum lipidomic profile associations with spontaneous preterm birth are influenced by body mass index. PLoS ONE. 15(11). Article e0239115. https://doi.org/10.1371/journal.pone.0239115.Harmonized procedures lead to comparable quantification of total oxylipins across laboratories-(Peer Reviewed Journal) Mainka, M., Dalle, C., Petera, M., Dalloux-Chioccioli, J., Kampschulte, N., Ostermann, A.I., Rothe, M., Bertrand-Michel, J., Newman, J.W., Gladine, C., Schebb, N.H. 2020. Harmonized procedures lead to comparable quantification of total oxylipins across laboratories. Journal of Lipid Research. 61(11):1424-1436. https://doi.org/10.1194/jlr.RA120000991.Linoleic acid-rich oil supplementation increases total and high-molecular-weight adiponectin and alters plasma oxylipins in postmenopausal women with metabolic syndrome-(Peer Reviewed Journal) Cole, R.M., Puchala, S., Ke, J., Abdel-Rasoul, M., Harlow, K., O'Donnell, B., Bradley, D., Andridge, R., Borkowski, K., Newman, J.W., Belury, M.A. 2020. Linoleic acid-rich oil supplementation increases total and high-molecular-weight adiponectin and alters plasma oxylipins in postmenopausal women with metabolic syndrome. Current Developments in Nutrition. 4(9). Article nzaa136. https://doi.org/10.1093/cdn/nzaa136.Impact of a weight loss and fitness intervention on exercise-associated plasma oxylipin patterns in obese, insulin-resistant, sedentary women-(Peer Reviewed Journal) Grapov, D., Fiehn, O., Campbell, C., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Keim, N.L., Hunter, G.R., Fernandez, J.R., Garvey, T., Hoppel, C.L., Harper, M., Newman, J.W., Adams, S.H. 2020. Impact of a weight loss and fitness intervention on exercise-associated plasma oxylipin patterns in obese, insulin-resistant, sedentary women. Physiological Reports. 8(17). Article e14547. https://doi.org/10.14814/phy2.14547.Metabolomics reveals altered hepatic bile acids, gut microbiome metabolites, and cell membrane lipids associated with marginal vitamin A deficiency in a Mongolian gerbil model-(Peer Reviewed Journal) La Frano, M.R., Brito, A., Johnson, C.M., Wilhelmson, B., Gannon, B., Fanter, R.K., Pedersen, T.L., Tanumihardjo, S.A., Newman, J.W. 2020. Metabolomics reveals altered hepatic bile acids, gut microbiome metabolites, and cell membrane lipids associated with marginal vitamin A deficiency in a Mongolian gerbil model. Molecular Nutrition and Food Research. 64(13). https://doi.org/10.1002/mnfr.201901319.Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low-density lipoproteins in isolated perfused rat livers-(Peer Reviewed Journal) Walker, R.E., Savinova, O.V., Pedersen, T.L., Newman, J.W., Shearer, G.C. 2021. Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low-density lipoproteins in isolated perfused rat livers. Physiological Reports. 9(4). Article e14480. https://doi.org/10.14814/phy2.14480.Urine metabolomics analysis associated with feed efficiency on crossbred steers during the growing and finishing period on forage- and concentrate-based diets-(Abstract Only) Artegoitia, V., Newman, J., Lewis, R., Foote, A.P., Freetly, H.C. 2020. Urine metabolomics analysis associated with feed efficiency on crossbred steers during the growing and finishing period on forage- and concentrate-based diets [abstract]. Journal of Animal Science. 98(Supplement 4):442. https://doi.org/10.1093/jas/skaa278.770.Gestational high-altitude hypoxia and metabolomic reprogramming in pulmonary arteries from fetal sheep-(Abstract Only) Leslie, E., Jones, B., Alvarez, R., Dasgupta, C., Fiehn, O., Bosviel, R., Newman, J.W., La Frano, M., Zhang, L., Wilson, S.M. 2020. Gestational high-altitude hypoxia and metabolomic reprogramming in pulmonary arteries from fetal sheep. Journal of Federation of American Societies for Experimental Biology. 34(S1). https://doi.org/10.1096/fasebj.2020.34.s1.03778.Alpha-Linolenic acid-enriched butter attenuated high fat diet-induced insulin resistance and inflammation by promoting bioconversion of n-3 PUFA and subsequent oxylipin formation-(Peer Reviewed Journal) Fan, R., Kim, J., You, M., Giraud, D., Toney, A.M., Shin, S., Kim, S., Borkowski, K., Newman, J.W., Chung, S. 2019. Alpha-Linolenic acid-enriched butter attenuated high fat diet-induced insulin resistance and inflammation by promoting bioconversion of n-3 PUFA and subsequent oxylipin formation. Journal of Nutritional Biochemistry. 76. https://doi.org/10.1016/j.jnutbio.2019.108285.Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum-(Peer Reviewed Journal) Rajan, M., Sotak, M., Barrenas, F., Shen, T., Borkowski, K., Ashton, N., Biorserud, C., Lindahl, T.L., Ramstrom, S., Scholl, M., Lindahl, P., Fiehn, O., Newman, J.W., Perkins, R., Wallenius, V., Lange, S., Borgeson, E. 2019. Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum. Scientific Reports. 9. https://doi.org/10.1038/s41598-019-51673-0.Luteal lipids regulate progesterone production and may modulate immune cell function during the estrous cycle and pregnancy-(Peer Reviewed Journal) Hughes, C.H., Bosviel, R., Newman, J.W., Pate, J.L. 2019. Luteal lipids regulate progesterone production and may modulate immune cell function during the estrous cycle and pregnancy. Frontiers in Endocrinology. 10. https://doi.org/10.3389/fendo.2019.00662.Acute hypercapnia/ischemia alters the esterification of arachidonic acid and docosahexaenoic acid epoxide metabolites in rat brain neutral lipids-(Peer Reviewed Journal) Otoki, Y., Metherel, A.H., Pedersen, T., Yang, J., Hammock, B.D., Bazinet, R.P., Newman, J.W., Taha, A.Y. 2019. Acute hypercapnia/ischemia alters the esterification of arachidonic acid and docosahexaenoic acid epoxide metabolites in rat brain neutral lipids. Lipids. 55(1):7-22. https://doi.org/10.1002/lipd.12197.Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles-(Peer Reviewed Journal) Foolad, N., Vaughn, A.R., Rybak, I., Burney, W., Chodur, G., Newman, J.W., Steinberg, F.M., Sivamani, R.K. 2019. Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles. Phytotherapy Research. 33(12):3212-3217. https://doi.org/10.1002/ptr.6495.Predicting the effects of supplemental EPA and DHA on the omega-3 index-(Peer Reviewed Journal) Walker, R.E., Harris Jackson, K., Tintle, N.L., Shearer, G.C., Bernasconi, A., Masson, S., Latini, R., Heydari, B., Kwong, R.Y., Flock, M., Kris-Etherton, P., Nedergaard Hedengran, A., Carney, R.M., Skulas-Ray, A., Gidding, S.S., Dewell, A., Gardner, C., Grenon, M.S., Sarter, B., Newman, J.W., Pedersen, T.L., Larson, M., Harris, W.S. 2019. Predicting the effects of supplemental EPA and DHA on the omega-3 index. American Journal of Clinical Nutrition. 110(4):1034-1040. https://doi.org/10.1093/ajcn/nqz161.A randomized controlled-feeding trial based on the Dietary Guidelines for Americans does not affect plasma trimethylamine N-oxide levels in women-(Abstract Only) Gertz, E.R., Krishnan, S., Peerson, J.M., Adams, S.H., Laugero, K.D., Newman, J.W., Keim, N.L., Bennett, B.J. 2019. A randomized controlled-feeding trial based on the Dietary Guidelines for Americans does not affect plasma trimethylamine N-oxide levels in women. Meeting Abstract. (3)1. https://doi.org/10.1093/cdn/nzz044.P08-031-19.Oxylipins in triglyceride-rich lipoproteins of dyslipidemic subjects promote endothelial inflammation following a high fat meal-(Peer Reviewed Journal) Rajamani, A., Borkowski, K., Akre, S., Fernandez, A., Newman, J.W., Simon, S.I., Passerini, A.G. 2019. Oxylipins in triglyceride-rich lipoproteins of dyslipidemic subjects promote endothelial inflammation following a high fat meal. Scientific Reports. 9:8655. https://doi.org/10.1038/s41598-019-45005-5.MS-based targeted metabolomics of eicosanoids and other oxylipins: analytical and inter-individual variabilities-(Peer Reviewed Journal) Gladine, C., Ostermann, A.I., Newman, J.W., Schebb, N.H. 2019. MS-based targeted metabolomics of eicosanoids and other oxylipins: analytical and inter-individual variabilities. Journal of Free Radical Biology and Medicine. 144:72-89. https://doi.org/10.1016/j.freeradbiomed.2019.05.012.Walnuts change lipoprotein composition suppressing TNFa-stimulated cytokine production by diabetic adipocyte-(Peer Reviewed Journal) Borkowski, K., Yim, S.J., Holt, R.R., Hackman, R.M., Keen, C.L., Newman, J.W., Shearer, G.C. 2019. Walnuts change lipoprotein composition suppressing TNFa-stimulated cytokine production by diabetic adipocyte. Journal of Nutritional Biochemistry. 68:51-58. https://doi.org/10.1016/j.jnutbio.2019.03.004.Weight loss and fitness intervention increases markers of hepatic bile acid (BA) synthesis, while reducing serum total BA concentrations in sedentary, obese insulin resistant women-(Abstract Only)Impact of post-collection freezing delay on the reliability of serum metabolomics in samples reflecting the California mid-term pregnancy biobank-(Peer Reviewed Journal) La Frano, M.R., Carmichael, S.L., Ma, C., Hardley, M., Shen, T., Wong, R., Rosales, L., Borlowski, K., Pedersen, T.L., Shaw, G., Stevenson, D.K., Fiehn, O., Newman, J.W. 2018. Impact of post-collection freezing delay on the reliability of serum metabolomics in samples reflecting the California mid-term pregnancy biobank. Metabolomics. 14:151. https://doi.org/10.1007/s11306-018-1450-9.Diet induced-obesity and weight loss alter bile acid profiles and gene expression in insulin target tissues-(Peer Reviewed Journal) Lafrano, M.R., Hernandez-Carretero, A., Weber, N., Borkowski, K., Pedersen, T.L., Newman, J.W., Osborn, O. 2018.  Diet induced-obesity and weight loss alter bile acid profiles and gene expression in insulin target tissues. Nutrition Research. 46:11-21. https://doi.org/10.1016/j.nutres.2017.07.006.Structural equation modeling of food craving across the menstrual cycle using behavioral, neuroendocrine, and metabolic factors-(Peer Reviewed Journal) Krishnan, S., Tryon, R.R., Agrawal, K., Welch, L.C., Horn, W.F., Newman, J.W., Keim, N.L. 2018. Structural equation modeling of food craving across the menstrual cycle using behavioral, neuroendocrine, and metabolic factors. Physiology and Behavior. 195:28-36. https://doi.org/10.1016/j.physbeh.2018.07.011.Non-invasive profiling of sweat-derived lipid mediators for cutaneous research-(Review Article) Agrawal, K., Sivamani, R., Newman, J.W. 2018. Non-invasive profiling of sweat-derived lipid mediators for cutaneous research. Skin Research and Technology. 58:188-195. https://doi: 10.1194/jlr.M071738.Oral ibuprofen differentially affects plasma and sweat lipid mediator profiles in healthy adult males-(Peer Reviewed Journal) Agrawal, K., Bosviel, R., Piccolo, B.D., Newman, J.W. 2018. Oral ibuprofen differentially affects plasma and sweat lipid mediator profiles in healthy adult males. Prostaglandins & Other Lipid Mediators. 137:1-8. https://doi.org/10.1016/j.prostaglandins.2018.05.009.Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles-(Peer Reviewed Journal) Agrawal, K., Hassoun, L.A., Foolad, N., Pedersen, T.L., Sivamani, R.K., Newman, J.W. 2018. Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles. Prostaglandins Leukotrienes and Essential Fatty Acids. 134:7-16. https://doi:10.1016/j.plefa.2018.05.001.Impact of an 8-week controlled feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indices-(Peer Reviewed Journal) Krishnan, S., Adams, S.H., Allen, L.H., Laugero, K.D., Newman, J.W., Stephensen, C.B., Burnett, D.J., Witbracht, M.G., Welch, L.C., Que, E.S., Keim, N.L. 2018. Impact of an 8-week controlled feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indices. American Journal of Clinical Nutrition. 108(2):266-278. https://doi.org/10.1093/ajcn/nqy113.A randomized controlled-feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indexes-(Peer Reviewed Journal) Krishnan, S., Adams, S.H., Allen, L.H., Laugero, K.D., Newman, J.W., Stephensen, C.B., Burnett, D.J., Witbracht, M., Welch, L.C., Que, E.S., Keim, N.L. 2018. A randomized controlled-feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indexes. American Journal of Clinical Nutrition. 108(2):266-278. https://doi.org/10.1093/ajcn/nqy113.A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction-(Peer Reviewed Journal) Killion, E.A., Reeves, A.R., El Azzouny, M.A., Yan, Q., Surujon, D., Griffin, J.D., Bowman, T.A., Wang, C., Matthan, N.R., Klett, E.L., Kong, D., Newman, J.W., Han, X., Lee, M., Coleman, R.A., Greenberg, A.S. 2018. A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction. Molecular Metabolism. 9:43-46. https://doi.org/10.1016/j.molmet.2018.01.012.A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction-(Peer Reviewed Journal) Killion, E.A., Reeves, A.R., El Azzouny, M.A., Yan, Q., Surujon, D., Griffin, J.D., Bowman, T.A., Wang, C., Matthan, N.R., Klett, E.L., Kong, D., Newman, J.W., Han, X., Lee, M., Coleman, R.A., Greenberg, A.S. 2018. A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction. Molecular Metabolism. 9:43-56. https://doi.org/10.1016/j.molmet.2018.01.012.Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids-(Peer Reviewed Journal) Shearer, G.C., Borkowski, K., Puumala, S.L., Harris, W.S., Pedersen, T.L., Newman, J.W. 2017. Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids. Prostaglandins Leukotrienes and Essential Fatty Acids. 128:1-10. https://doi.org/10.1016/j.plefa.2017.10.006.Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults-(Peer Reviewed Journal) Baldiviez, L.M., Keim, N.L., Laugero, K.D., Hwang, D.H., Huang, L., Woodhouse, L.R., Burnett, D.J., Zerofsky, M., Bonnel, E., Allen, L.H., Newman, J.W., Stephensen, C.B. 2017. Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults. Biomed Central (BMC) Nutrition. 3(79):1-13. https://doi.org/10.1186/s40795-017-0197-4.Establishing and performing targeted multi-residue analysis for lipid mediators and fatty acids in small clinical plasma samples.-(Book / Chapter) Pedersen, T.L., Newman, J.W. 2018. Establishing and performing targeted multi-residue analysis for lipid mediators and fatty acids in small clinical plasma samples. In: Giera, M, editor. Clinical Metabolomics. Methods in Molecular Biology. Volume 1730. New York, NY: Humana Press. p. 175-212. https://doi.org/10.1007/978-1-4939-7592-1_13Aberrant fatty acid metabolism in the skeletal muscle contributes to insulin resistance in zinc transporter 7 (Znt7) knockout mice-(Peer Reviewed Journal) Huang, L., Tepaamorndech, S., Kirschke, C.P., Newman, J.W., Keyes, W.R., Pedersen, T.L. 2018. Aberrant fatty acid metabolism in the skeletal muscle contributes to insulin resistance in zinc transporter 7 (Znt7) knockout mice. Journal of Biological Chemistry. 293(20):7549-7563. doi:10.1074/jbc.M117.817692.Effects of stimulation technique, anatomical region and time on human sweat lipid mediator profiles.-(Peer Reviewed Journal) Agrawal, K., Waller, J.D., Pedersen, T.L., Newman, J.W. 2017. Effects of stimulation technique, anatomical region and time on human sweat lipid mediator profiles. Prostaglandins & Other Lipid Mediators. 134:84-92. https://doi.org/10.1016/j.prostaglandins.2017.09.007.Obesity-induced changes in lipid mediators persist after weight loss-(Peer Reviewed Journal) Hernandez-Carretero, A., Weber, N., La Frano, M.R., Ying, M., Lantero Rodriguez, J., Sears, D.D., Wallenius, V., Borgeson, E., Newman, J.W., Osborn, O. 2017. Obesity-induced changes in lipid mediators persist after weight loss. International Journal of Obesity. 46:11-21. https://doi.org/10.1016/j.nutres.2017.07.006.Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation-(Peer Reviewed Journal) Tian, J., Zhu, J., Yi, Y., Li, C., Zhang, Y., Zhao, Y., Pan, C., Xiang, S., Li, X., Li, J., Newman, J.W., Feng, X., Liu, J., Han, J., Wang, L., La Frano, M.R., Liang, A. 2017. Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. Scientific Reports. 7:8938. https://doi.org/10.1038/s41598-017-09131-2.Associations among fatty acids, desaturase and elongase, and insulin resistance in children-(Peer Reviewed Journal) Beccarelil, L.M., Scheer, R.E., Newman, J.W., Borkowska, A.G., Gray, I.J., Linnell, J.D., Keen, C., Young, H. 2017. Associations among fatty acids, desaturase and elongase, and insulin resistance in children. Journal of American College of Nutrition. 37:44-50. https://doi.org/10.1080/07315724.2017.1347908.The human serum metabolome of vitamin B-12 deficiency and repletion, and associations with neurological function-(Peer Reviewed Journal) Brito, A., Grapov, D., Fahrmann, J., Harvey, D., Green, R., Miller, J.W., Fedosov, S.N., Shahab-Ferdows, S., Hampel, D., Pedersen, T.L., Fiehn, O., Newman, J.W., Uauy, R., Allen, L.H. 2017. The human serum metabolome of vitamin B-12 deficiency and repletion, and associations with neurological function. Journal of Nutrition. 147(10):1839-1849. https://doi.org/10.3945/jn.117.248278.Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial-(Peer Reviewed Journal) Agrawal, K., Melliou, E., Li, X., Pedersen, T.L., Wang, S.C., Magiatis, P., Newman, J.W., Holt, R.R. 2017. Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial. Journal of Functional Foods. 36:84-93. doi: 10.1016/j.jff.2017.06.046.Dietary docosahexaenoic acid and trans-10, cis-12-conjugated linoleic acid alter oxylipins profiles in mouse adipose tissue-(Peer Reviewed Journal) Adkins, Y.C., Belda, B.J., Pedersen, T.L., Mackey, B.E., Newman, J.W., Kelley, D.S. 2017. Dietary docosahexaenoic acid and trans-10, cis-12-conjugated linoleic acid alter oxylipins profiles in mouse adipose tissue. Lipids. 52(5):399-413.Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability, and microbial dysbiosis in high fat-fed mice-(Peer Reviewed Journal) Hamilton, K.M., Ronveaux, C.C., Rust, B., Newman, J.W., Hawley, M., Barile, D., Mills, D., Raybould, H.E. 2017. Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability, and microbial dysbiosis in high fat-fed mice. American Journal of Physiology - Gastrointestinal and Liver Physiology. 312:G474–G487. https://doi.org/10.1152/ajpgi.00427.2016.Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance-(Peer Reviewed Journal) Olmstead, K.I., Lafrano, M.R., Fahrmann, J., Grapov, D., Viscarra, J.A., Newman, J.W., Oliver, F., Crocker, D.E., Filipp, F.V., Ortiz, R.M. 2017. Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance. Metabolomics. 13:60. doi: 10.1007/s11306-017-1186-y.Metabolic perturbations of postnatal growth restriction and hyperoxia-induced pulmonary hypertension in a bronchopulmonary dysplasia model-(Peer Reviewed Journal) La Frano, M.R., Fahrmann, J.F., Grapov, D., Fiehn, O., Pedersen, T.L., Newman, J.W., Underwood, M.A., Steinhorn, R.H., Wedgwood, S. 2017. Metabolic perturbations of postnatal growth restriction and hyperoxia-induced pulmonary hypertension in a bronchopulmonary dysplasia model. Metabolomics. 13:32. https://doi.org/10.1007/s11306-017-1170-6.Metabolic perturbations of postnatal growth restriction and hyperoxia-induced pulmonary hypertension in a bronchopulmonary dysplasia model-(Peer Reviewed Journal) La Frano, M.R., Fahrmann, J.F., Grapov, D., Fiehn, O., Pedersen, T.L., Newman, J.W., Underwood, M.A., Steinhorn, R.H., Wedgwood, S. 2017. Metabolic perturbations of postnatal growth restriction and hyperoxia-induced pulmonary hypertension in a bronchopulmonary dysplasia model. Metabolomics. 32:13.Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons-(Peer Reviewed Journal) Zhang, J., Light, A.R., Hoppel, C.L., Campbell, C., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Hughen, R.W., Keim, N.L., Newman, J.W., Hunter, G.R., Fernandez, J.R., Garvey, W.T., Harper, M., Fiehn, O., Adams, S.H. 2017. Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons. Experimental Physiology. 102(1):48-69. doi:10.1113/EP086019.Sweat lipid mediator profiling: a non-invasive approach for cutaneous research-(Abstract Only) Agrawal, K., Hassoun, L., Notay, M., Foolad, N., Sivamani, R.K., Newman, J.W. 2016. Inflammatory Mediator Profiling in Sweat: A Potential Noninvasive Diagnostic for Inflammatory Skin Diseases. Meeting Abstract. LIPID MAPS Annual Meeting 2016, May 17-18, 2016, La Jolla, CA.Circulating levels of endocannabinoids and oxylipins altered by dietary lipids in older women are likely associated with previously identified gene targets-(Peer Reviewed Journal) Watkins, B.A., Kim, J., Kenny, A., Pedersen, T.L., Pappan, K.L., Newman, J.W. 2016. Circulating levels of endocannabinoids and oxylipins altered by dietary lipids in older women are likely associated with previously identified gene targets. BBA Molecular and Cell Biology of Lipids. 1861(11). doi: 10.1016/j.bbalip.2016.07.007.Perinatal triphenyl phosphate exposure accelerates type 2 diabetesonset and increases adipose accumulation in UCD-type 2 diabetesmellitus rats-(Peer Reviewed Journal) Green, A.J., Graham, J.L., Gonzalez, E.A., Lafrano, M.R., He, G., Pertopoulou, S.E., Park, J., Denison, M., Newman, J.W. 2016. Perinatal exposure to the flame retardant triphenyl phosphate accelerates the onset of type 2 diabetes and causes adipose accumulation in UCD-type 2 diabetes mellitus rats. Reproductive Toxicology. pii: S0890-6238(16)30266-0. doi: 10.1016/j.reprotox.2016.07.009.Using a lipidomics approach for nutritional phenotyping in response to a test meal containing gamma-linolenic acid-(Peer Reviewed Journal) Cajka, T., Davis, R., Austin, K.J., Newman, J.W., German, J., Fiehn, O., Smilowitz, J.T. 2016. Using a lipidomics approach for nutritional phenotyping in response to a test meal containing gamma-linolenic acid. Journal of Proteome Research. 12:127. doi: 10.1007/s11306-016-1075-9.Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese health study-(Peer Reviewed Journal) Sun, Y., Koh, H.W., Choi, H., Koh, W., Yuan, J., Newman, J.W., Su, J., Fang, J., Ong, C., Van Dam, R.M. 2016. Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese health study. Journal of Lipid Research. 57:1300-1307.Association between plasma endocannabinoids and appetite in hemodialysis patients: a pilot study-(Peer Reviewed Journal) Freidman, A.N., Kim, J., Kaiser, S., Pedersen, T., Newman, J.W., Watkins, B.A. 2016. Association between plasma endocannabinoids and appetite in hemodialysis patients: a pilot study. American Journal of Kidney Diseases. 36(7):658-662. doi: 10.1016/j.nutres.2016.03.009.A randomized placebo controlled trial of ibuprofen for respiratory syncytial infection in a bovine model study-(Peer Reviewed Journal) Walsh, P., Behrens, N., Crvallo Chaigneau, F.R., Mcelligot, H., Agrawal, K., Newman, J.W., Andersen, M., Gershwin, L.J. 2016. A randomized placebo controlled trial of ibuprofen for respiratory syncytial infection in a bovine model study. PLoS One. 11(4):e0152913. doi: 10.1371/journal.pone.0152913.Bile Acid Responses in Methane and Non-Methane Producers to Standard Breakfast Meals-(Abstract Only) Rust, B., La Frano, M., Newman, J.W., Agrawal, K., Horn, W.F., Welch, L., Marco, M., Martin, R., Keim, N.L. 2016. Bile Acid Responses in Methane and Non-Methane Producers to Standard Breakfast Meals. Meeting Abstract. Experimental Biology 2016, San Diego, CA April 2-6, 2016.Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice-(Peer Reviewed Journal) Midtbø, L.K., Borkowska, A.G., Bernhard, A., Rønnevik, A.K., Lock, E., Fitzgerald, M.L., Torstensen, B.E., Liaset, B., Brattelid, T., Pedersen, T.L., Newman, J.W., Kristiansen, K., Madsen, L. 2015. Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice. Journal of Nutritional Biochemistry. 26(6):585-595. doi: 10.1016/j.jnutbio.2014.12.005.The elusive endogenous adipogenic PPARy agonists: lining up the suspects-(Review Article) Hallenborg, P., Petersen, R.K., Newman, J.W., Madsen, L., Kristiansen, K. 2015. The elusive endogenous adipogenic PPARy agonists: lining up the suspects. Cell Metabolism. 61:149-162. doi: 10.1016/j.plipres.2015.11.002.Effects of Extra Virgin Olive Oil (EVOO) Oleocanthal and Oleacein Content on Platelet Reactivity in Healthy Adults-(Abstract Only) Holt, R.R., Agarwal, K., Li, X., Melliou, E., Pedersen, T., Wang, S., Flynn, D., Magiatis, P., Newman, J.W. 2016. Effects of Extra Virgin Olive Oil (EVOO) Oleocanthal and Oleacein Content on Platelet Reactivity in Healthy Adults. Meeting Abstract. Experimental Biology 2016, San Diego CA Apr. 2-6.Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activity and glucose uptake-(Peer Reviewed Journal) Tepaamorndech, S., Kirschke, C.P., Pedersen, T.L., Keyes, W.R., Newman, J.W., Huang, L. 2015. Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activity and glucose uptake. FEBS Journal. 283(2):378-394. doi: 10.1111/febs.13582.Antioxidant supplementation and obesity have independent effects on hepatic oxylipin profiles in insulin resistant, obese-prone rats-(Peer Reviewed Journal) Picklo, M.J., Newman, J.W. 2015. Antioxidant supplementation and obesity have independent effects on hepatic oxylipin profiles in insulin resistant, obese-prone rats. Free Radical Biology and Medicine. 89:182-191.Effects of short-term walnut consumption on human microvascular function and its relationship to plasma epoxide content-(Review Article) Holt, R.R., Yim, S., Shearer, G.C., Hackman, R.M., Djurica, D., Newman, J.W., Shindel, A.W., Keen, C.L. 2015. Effects of short-term walnut consumption on human microvascular function and its relationship to plasma epoxide content. Journal of Nutritional Biochemistry. 26(12):1458-1466. https://doi.org/10.1016/j.jnutbio.2015.07.012.Dietary DHA reduced downstream endocannabinoid and inflammatory gene expression, epididymal fat mass, and improved aspects of glucose use in muscle in C57BL/6J mice-(Peer Reviewed Journal) Kim, J., Carlson, M.E., Kuchel, G.A., Newman, J.W., Watkins, B.A. 2015. Dietary DHA reduced downstream endocannabinoid and inflammatory gene expression, epididymal fat mass, and improved aspects of glucose use in muscle in C57BL/6J mice. International Journal of Obesity. 40:129–37; doi: 10.1038/ijo.2015.135.Mutations in durum wheat SBEII genes conferring increased amylose and resistant starch affect grain yield components, semolina and pasta quality and fermentation responses in rats-(Peer Reviewed Journal) Hazard, B., Zhang, X., Naemeh, R., Hamilton, K.M., Rust, B., Raybould, H.E., Newman, J.W., Martin, R., Dubcovsky, J. 2015. Mutations in durum wheat SBEII genes conferring increased amylose and resistant starch affect grain yield components, semolina and pasta quality and fermentation responses in rats. Crop Science. 55(6):2813–2825. doi: 10.2135/cropsci2015.03.0179.A novel approach to identify optimal metabotypes of elongase and desaturase activities in prevention of acute coronary syndrome-(Peer Reviewed Journal) Tintle, N.L., Newman, J.W., Shearer, G.C. 2015. A novel approach to identify optimal metabotypes of elongase and desaturase activities in prevention of acute coronary syndrome. Metabolomics. 11(1):1-11. doi: 10.1007/s11306-015-0787-6.Hepatic oxylipin profiles in obese rats: Effect of antioxidant supplementation-(Abstract Only) Picklo, M.J., Newman, J.W. 2015. Hepatic oxylipin profiles in obese rats: Effect of antioxidant supplementation [abstract]. Journal of Federation of American Societies for Experimental Biology. 29:389.2.Short chain fatty acid production and glucose responses by methane producers-(Abstract Only) Rust, B., Gray, I.J., Keifer, D., Newman, J.W., Cooper, D., Welch, L., Horn, W.F., Marco, M., Pelkman, C., Keim, N.L. 2014. Short chain fatty acid production and glucose responses by methane producers. Meeting Abstract. Experimental Biology Meeting, Boston MA, March 28-April 1, 2015.The omega-3 fatty acid DHA dose-dependently reduces atherosclerosis: a putative role for F4-neuroprostanes a specific class of peroxidized metabolites-(Peer Reviewed Journal) Gladine, C., Newman, J.W., Durand, T., Pedersen, T.L., Galano, J., Demougeot, C., Berdeaux, O., Pujos-Guillot, E., Mazur, A., Comte, B. 2014. The omega-3 fatty acid DHA dose-dependently reduces atherosclerosis: a putative role for F4-neuroprostanes a specific class of peroxidized metabolites. PLoS One. 9(11):e111471.Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin-(Peer Reviewed Journal) Campbell, C., Grapov, D., Fiehn, O., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Gustafson, M.B., Keim, N.L., Newman, J.W., Hunter, G.R., Fernandez, J.R., W. Timothy, G., Harper, M., Hoppel, C.L., Meissen, J.K., Takeuchi, K., Adams, S.H. 2014. Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin. PLoS One. 9(1):e84260. DOI: 10.1371/journal.pone.0084260.Habitual physical activity and plasma metabolomics patterns distinguish individuals with low- versus high-weight loss during controlled energy restriction-(Peer Reviewed Journal) Piccolo, B., Van Loan, M.D., Gertz, E.R., Woodhouse, L.R., Souza, E., Gustafson, M.B., Campbell, C., Fiehn, O., Keim, N.L., Adams, S.H., Newman, J.W. 2015. Habitual physical activity and plasma metabolomics patterns distinguish individuals with low- versus high-weight loss during controlled energy restriction. Journal of Nutrition. 145(4):681-690. doi: 10.3945/jn.114.201574.Effect of omega-3 fatty acids on the oxylipin composition of lipoproteins in hypertriglyceridemic, statin-treated subjects-(Peer Reviewed Journal) Newman, J.W., Pedersen, T.L., Brandenburg, V.R., Harris, W.S., Shearer, G.C. 2014. Effect of omega-3 fatty acids on the oxylipin composition of lipoproteins in hypertriglyceridemic, statin-treated subjects. PLoS One. 9(11):e111471. doi: 10.1371/journal.pone.0111471.Perinatal exposure to the pesticide DDT impairs energy expenditure and metabolism in adult female mice-(Peer Reviewed Journal) La Merrill, M., Karey, E., Moshier, E., Lindtner, C., La Frano, M., Newman, J.W., Buettner, C. 2014. Perinatal exposure to the pesticide DDT impairs energy expenditure and metabolism in adult female mice. PLoS One. 9(7):e103337. doi: 10.1371/journal.pone.0103337.Metabolomics:  Insulin Resistance and Type 2 Diabetes Mellitus-(Book / Chapter) Adams, S.H., Newman, J.W. 2015. Metabolomics:  Insulin Resistance and Type 2 Diabetes Mellitus. Book Chapter. DOI: 10.1002/9781118387658.ch18.A diet containing a nonfat dry milk matrix significantly alters systemic endocannabinoids and oxylipins in diet-induced obese mice-(Peer Reviewed Journal) Dunn, T.N., Keenan, A.H., Thomas, A.P., Newman, J.W., Adams, S.H. 2014. A diet containing a nonfat dry milk matrix significantly alters systemic endocannabinoids and oxylipins in diet-induced obese mice. Nutrition and Metabolism. 11:1-12.Indomethacin treatment prevents diet-induced obesity and insulin resistance, but not glucose intolerance in C57BL/6J mice-(Peer Reviewed Journal) Fjaere, E., Aune, U., Keenan, A., Ma, T., Lillefosse, H., Xi, Y., Newman, J.W., Haj, F., Liaset, B., Kristiansen, K., Madsen, L. 2014. Indomethacin treatment prevents diet-induced obesity and insulin resistance, but not glucose intolerance in C57BL/6J mice. Journal of Biological Chemistry. DOI: 10.1074/jbc.M113525220.Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice-(Peer Reviewed Journal) Schuster, G.U., Bratt, J., Jiang, X., Pedersen, T.L., Grapov, D., Adkins, Y.C., Kelley, D.S., Newman, J.W., Kenyon, N.J., Stephensen, C.B. 2014. Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. American Journal of Respiratory Cell and Molecular Biology. doi: 10.1165/rcmb.2013-0136OC.Association between subcutaneous white adipose tissue and serum 25-hydroxyvitamin D in overweight and obese adults-(Peer Reviewed Journal) Piccolo, B.D., Dolnikowski, G., Seyoum, E., Thomas, A., Gertz, E.R., Souza, E.C., Keim, N.L., Adams, S.H., Newman, J.W., Woodhouse, L.R., Van Loan, M.D. 2013. Association between subcutaneous white adipose tissue and serum 25-hydroxyvitamin D in overweight and obese adults. American Journal of Clinical Nutrition. 5(9), 3352-3366. DOI:10.3390/nu5093352.Direct comparison of fatty acid ratios in single cellular lipid droplets as determined by Raman spectroscopy and gas chromatography-(Peer Reviewed Journal) Schie, I.W., Pedersen, T.L., Smith, Z., Wu, J., Newman, J.W., Huser, T., Noltel, L., Yahiatene, I. 2013. Direct comparison of fatty acid ratios in single cellular lipid droplets as determined by Raman spectroscopy and gas chromatography. Analyst. doi: 10.1039/C3AN00970J.High dose simvastatin exhibits enhanced lipid lowering effects relative to simvastatin/ezetimibe combination therapy-(Peer Reviewed Journal) Snowden, S.G., Grapov, D., Nygren, H., Settergren, M., D'Alexandri, F.L., Haeggstrom, J.Z., Hyotylainen, T., Oresic, M., Pedersen, T.L., Newman, J.W., Pernow, J., Wheelock, C.E. 2014. High dose simvastatin exhibits enhanced lipid lowering effects relative to simvastatin/ezetimibe combination therapy. Circulation: Cardiovascular Genetics. 7:955-964. doi: 10.1161/CIRCGENETICS.114.000606.Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets-(Peer Reviewed Journal) Bruins, M.J., Dane, A.D., Strassburg, K., Vreeken, R.J., Newman, J.W., Salem, Jr, N., Tyburczy, C., Brenna, J.T. 2013. Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets. Journal of Lipid Research. 54(6):1598-1607.Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model-(Peer Reviewed Journal) Zunino, S.J., Storms, D.H., Newman, J.W., Pedersen, T.L., Keen, C.L., Ducore, J.M. 2013. Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model. International Journal of Oncology. 42:741-748. DOI: 10.3892/ijo.2012.1734.The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose and muscle-(Peer Reviewed Journal) Fedor, D.M., Adkins, Y.C., Newman, J.W., Mackey, B.E., Kelley, D.S. 2013. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose and muscle. Metabolic Syndrome and Disorders. 11(1):63-70. DOI: 10.1089/met.2012.0116.Type 2 diabetes associated changes in the plasma non-esterified fatty acids, oxylipins and endocannabinoids-(Peer Reviewed Journal) Grapov, D., Adams, S.H., Pedersen, T.L., Garvey, W.T., Lok, K.H., Newman, J.W. 2012. Type 2 diabetes associated changes in the plasma non-esterified fatty acids, oxylipins and endocannabinoids. PLoS One. 7(11):e48852.Dietary resveratrol does not delay engraftment, sensitize to vincristine, or inhibit growth of high-risk acute lymphoblastic leukemia cells in NOD/SCID mice-(Peer Reviewed Journal) Zunino, S.J., Storms, D.H., Newman, J.W., Pedersen, T.L., Keen, C.L., Ducore, J.M. 2012. Dietary resveratrol does not delay engraftment, sensitize to vincristine, or inhibit growth of high-risk acute lymphoblastic leukemia cells in NOD/SCID mice. International Journal of Oncology. 41(6):2207-2212. DOI: 10.3892/ijo.2012.1650.Daily consumption of orange-fleshed sweet potato with added fat tends to increase total body vitamin A pool size in vitamin A depleted Bangladeshi women-(Peer Reviewed Journal)IRF-1 and miRNA126 modulate inflammatory VCAM-1 expression in response to a high fat meal-(Peer Reviewed Journal) Sun, C., Alkhoury, K., Wang, Y.I., Foster, G.A., Radecke, C.E., Tam, K., Edwards, C.M., Facciotti, M.T., Armstrong, E.J., Knowlton, A.A., Newman, J.W., Passerini, A.G., Simon, S.I. 2012. IRF-1 and miRNA126 modulate inflammatory VCAM-1 expression in response to a high fat meal. Circulation Research. 111:1054-1064.imDEV: a graphical user interface to R multivariate analysis tools in Microsoft Excel-(Peer Reviewed Journal) Grapov, D., Newman, J.W. 2012. imDEV: a graphical user interface to R multivariate analysis tools in Microsoft Excel. Oxford University Press. doi:10.1093.Vitamin B-12 supplementation of rural Mexican women changes biochemical B-12 status indicators but does not affect hematology or a bone turnover marker-(Peer Reviewed Journal) Shahab-Ferdows, S., Anaya-Loyola, M.A., Vergara-Castaneda, H., Rosado, J., Keyes, W.R., Newman, J.W., Miller, J., Allen, L.H. 5012. Vitamin B-12 supplementation of rural Mexican women changes biochemical B-12 status indicators but does not affect hematology or a bone turnover marker. Journal of Nutrition. vol. 142, no. 10, 1881-1887.Quantitative profiling of oxylipins through comprehensive lc-ms/ms analysis: Application in cardiac surgery-(Peer Reviewed Journal) Strassburg, K., Pedersen, T.L., Huijbrechts, A.M., Kortekaas, K., Lindeman, J., Dane, A., Berger, R., Brenkman, A., Hankemeier, T., Van Duynhoven, J., Kalkhoven, E., Newman, J.W., Vreeken, R. 2012. Quantitative profiling of oxylipins through comprehensive lc-ms/ms analysis: Application in cardiac surgery. Analytical and Bioanalytical Chemistry. 404(5):1413-1426.Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-HUFA in healthy volunteers-(Peer Reviewed Journal) Keenan, A.H., Pedersen, T.L., Fillaus, K., Larson, M.K., Shearer, G.C., Newman, J.W. 2012. Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-HUFA in healthy volunteers. Journal of Lipid Research. doi: 10.1194.Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans-(Peer Reviewed Journal) Armstrong, P., Kelley, D.S., Newman, J.W., Staggers, F., Hartiala, J., Allayee, H., Stephensen, C.B. 2012. Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans. Journal of Nutrition. 142(8):1417-1428. DOI: 10.3945/jn.112.159814.Variations in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful?-(Peer Reviewed Journal) Krishnan, S., Newman, J.W., Hembrooke, T.A., Keim, N.L. 2012. Variations in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful?. Nutrition and Metabolism. 9:26.Variation in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful?-(Peer Reviewed Journal) Krishnan, S., Newman, J.W., Hembrooke, T.A., Keim, N.L. 2012. Variation in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful?. Journal of Nutrition and Metabolism. 9(1):26.Saturated fatty acids activate TLR-mediated pro-inflammatory signaling pathways-(Peer Reviewed Journal) Huang, S., Rutkowsky, J.M., Snodgrass, R.G., Ono-Moore, K., Schneider, D.A., Newman, J.W., Adams, S.H., Hwang, D.H. 2012. Saturated fatty acids activate TLR-mediated pro-inflammatory signaling pathways. Journal of Lipid Research. Epublished. DOI: 10.1194/jlr.D029546.Resveratrol given intraperitoneally does not inhibit growth of high-risk t(4;11) acute lymphoblastic leukemia cells in NOD/SCID mouse model-(Peer Reviewed Journal) Zunino, S.J., Storms, D.H., Newman, J.W., Pedersen, T.L., Keen, C.L., Ducore, J.M. 2012. Resveratrol given intraperitoneally does not inhibit growth of high-risk t(4;11) acute lymphoblastic leukemia cells in NOD/SCID mouse model. International Journal of Oncology. 40(4):1277-84. DOI:10.3892/IJO.2011.1316.An optimized method for measuring methylmalonic acid in low volumes of serum using UPLC-MS/MS-(Peer Reviewed Journal) Pedersen, T.L., Keyes, W.R., Shahab-Ferdows, S., Allen, L.H., Newman, J.W. 2011. An Optimized Method for Measuring Methylmalonic Acid in Low Volumes of Serum Using UPLC-MS/MS. Journal of Chromatography. B. 879, 1502-6.Effects of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women-(Peer Reviewed Journal) Bendensen, N.T., Stender, S., Szecsi, P.B., Pedersen, S.B., Basu, S., Hellgren, L.I., Newman, J.W., Larsen, T.M., Haugaard, S.B., Astrup, A. 2011. Effects of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women. Journal of Lipid Research. doi 10.1194/jlr.M014738.ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation-(Peer Reviewed Journal) Stephensen, C.B., Armstrong, P., Newman, J.W., Pedersen, T.L., Legault, J., Schuster, G., Kelley, D.S., Vikman, S., Hartiala, J., Hooman, A. 2011. ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. Journal of Lipid Research. 52(5):991-1003.The human serum metabolome-(Peer Reviewed Journal) Psychogios, N., Hau, D.D., Peng, J., Guo, A., Mandal, R., Bouatra, S., Sinelnikov, I., Krishnamurthy, R., Eisner, R., Gautam, B., Young, N., Xia, J., Knox, C., Dong, E., Huang, P., Hollander, Z., Pedersen, T.L., Smith, S.R., Bamforth, F., Greiner, R., Mcmanus, B., Newman, J.W., Goodfriend, T., Wishart, D.S. 2011. THE HUMAN SERUM METABOLOME. PLoS One. 6(2): e16957.12- and 15-lipoxygenases in human carotid atherosclerotic lesions: Associations with cerebrovascular symptoms-(Peer Reviewed Journal) Gertow, K., Nobili, E., Folkersen, L., Newman, J.W., Pedersen, T.L., Swedenborg, J., Paulsson-Berne, G., Kuhn, H., Hedin, U., Wheelock, C.E., Hansson, G.K., Haeggstrom, J.Z., Gabrielsen, A. 2011. 12- and 15-lipoxygenases in human carotid atherosclerotic lesions: Associations with cerebrovascular symptoms. Atherosclerosis. 215:411-416.Effects of dynamic exercise on plasma arachidonic acid epoxides and diols in human volunteers-(Peer Reviewed Journal) Giordano, R.M., Newman, J.W., Pedersen, T.L., Ramos, M.I., Stebbins, C. 2011. Effects of dynamic exercise on plasma arachidonic acid epoxides and diols in human volunteers. American Journal of Clinical Nutrition. doi: 21, 471-479.Impact of a UCP3 Loss-of-Function Polymorphism on the Plasma Metabolomic Profile in Obese African-American Women-(Peer Reviewed Journal) Piccolo, B.D., Grapov, D., Adams, S.H., Hoppel, C., Garvey, W., Fiehn, O., Harper, M., Newman, J.W. 2010. Impact of a UCP3 Loss-of-Function Polymorphism on the Plasma Metabolomic Profile in Obese African-American Women. Journal of Federation of American Societies for Experimental Biology. https://doi.org/10.1371/journal.pone.0015234.s002.Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and Type 2 diabetic obese African-American women-(Peer Reviewed Journal) Fiehn, O., Garvey, W., Newman, J.W., Lok, K.H., Hoppel, C.L., Adams, S.H. 2010. Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women. PLoS One. Vol.5(12): e15234.Web-enabled and improved software tools and data are needed to measure nutrient intakes and physical activity for personalized health research-(Peer Reviewed Journal) Stumbo, P.J., Weiss, R., Newman, J.W., Pennington, J.A., Tucker, K.L., Wiesenfield, P., Illner, A., Klurfeld, D.M., Kaput, J. 2010. Web-enabled and improved software tools and data are needed to measure nutrient intakes and physical activity for personalized health research. Journal of Nutrition. 140:2104-2115.Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study-(Peer Reviewed Journal) Van Erk, M.J., Wopereis, S., Rubingh, C., Van Vliet, T., Verheij, E., Cnubben, N., Pedersen, T.L., Newman, J.W., Age, S., Van Der Greef, J., Hendriks, H., Van Ommen, B. 2010. Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study. Biomed Central (BMC) Genomics.  3:5.Trans fatty acids adversely affect blood lipids but not intra-abdominal and liver fat deposition - a randomized trial in overweight postmenopausal women-(Peer Reviewed Journal) Bendsen, N.T., Chabanova, E., Thomsen, H.S., Larsen, T.M., Newman, J.W., Stender, S., Dyerberg, J., Haugaard, S.B., Astrup, A. 2010. Trans fatty acids adversely affect blood lipids but not intra-abdominal and liver fat deposition - a randomized trial in overweight postmenopausal women. Nutrition and Diabetes. 1:e4; 10.1038.Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters-(Peer Reviewed Journal) Shearer, G.C., Harris, W.S., Pedersen, T.L., Newman, J.W. 2010. DETECTION OF OMEGA-3 OXYLIPINS IN HUMAN PLASMA AND RESPONSE TO TREATMENT WITH OMEGA-3 ACID ETHYL ESTERS. Journal of Lipid Research. 51(8):2074-81.Impact of circulating esterified eicosanoids and other oxylipins on endothelial function-(Peer Reviewed Journal) Shearer, G., Newman, J.W. 2009. Impact of circulating esterified eicosanoids and other oxylipins on endothelial function. Current Atherosclerosis Reports. Vol. 11:403-410.INCREASED EXPRESSION OF RECEPTORS FOR OREXIGENIC FACTORS IN NODOSE GANGLION OF DIET-INDUCED OBESE RATS-(Peer Reviewed Journal) Paulino, G., Barbier De La Serre, C., Knotts, T.A., Oort, P.J., Newman, J.W., Adams, S.H., Raybould, H. 2009. INCREASED EXPRESSION OF RECEPTORS FOR OREXIGENIC FACTORS IN NODOSE GANGLION OF DIET-INDUCED OBESE RATS. American Journal of Physiology - Endocrinology and Metabolism, 296:898-903.ADMINISTRATION OF A SUBSTITUTED ADAMANTLY-UREA INHIBITOR OF THE SOLUBLE EPOXIDE HYDROLASE PROTECTS THE KIDNEY FROM DAMAGE IN HYPERTENSIVE GOTO-KAKIZAKI RATS-(Peer Reviewed Journal) Olearczyk, J.J., Quigley, J.E., Mitchell, B.C., Yamamoto, T., Kim, I., Newman, J.W., Luria, A., Hammock, B.D., Imig, J.D. 2010. ADMINISTRATION OF A SUBSTITUTED ADAMANTLY-UREA INHIBITOR OF THE SOLUBLE EPOXIDE HYDROLASE PROTECTS THE KIDNEY FROM DAMAGE IN HYPERTENSIVE GOTO-KAKIZAKI RATS. Trade Journal Publication. 10.1042/CS20080039.Plasma Acylcarnitine Profiles Suggest Incomplete Fatty Acid ß-Oxidation and Altered Tricarboxylic Cycle Activity in Type 2 Diabetic African-American Women-(Peer Reviewed Journal) Adams, S.H., Hoppel, C.L., Lok, K.H., Zhao, L., Wong, S.W., Minkler, P.E., Hwang, D.H., Newman, J.W., Garvey, W.T. 2009. Plasma Acylcarnitine Profiles Suggest Incomplete Fatty Acid ß-Oxidation and Altered Tricarboxylic Cycle Activity in Type 2 Diabetic African-American Women. Journal of Nutrition, 139:1073-1081.TRIGLYCERIDE-RICH LIPOPROTEIN LIPOLYSIS RELEASES NEUTRAL AND OXIDIZED FREE FATTY ACIDS THAT INDUCE ENDOTHELIAL CELL INFLAMMATION-(Peer Reviewed Journal) Wang, L., Gill, R., Pedersen, T.L., Higgins, L.J., Newman, J.W., Rutledge, J.C. 2008. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized free fatty acids that induce endothelial cell inflammation. Journal of Lipid Research.  Papers in press published ahead of print, doi:10.1194/jlr.M700505-JLR200LIPOPROTEIN LIPASE RELEASES ESTERIFIED OXYLIPINS FROM VERY LOW-DENSITY LIPOPROTEINS.-(Peer Reviewed Journal) Shearer, G.C., Newman, J.W. 2008. Lipoprotein lipase releases esterified oxylipins from very low-density lipoproteins. Prostaglandins Leukot. Essent. Fatty Acids. 79:215-222.PHOSPHOLIPASE A2 REDUCTION AMELIORATES COGNITIVE DEFICITS IN MOUSE MODEL OF ALZHEIMER’S DISEASE-(Peer Reviewed Journal) Sanchez-Mejia, R.O., Newman, J.W., Toh, S., Yu, G., Zhou, Y., Scearce-Levie, K., Cheng, I.H., Gan, L., Palop, J.J., Bonventre, J.V., Mucke, L. 2008. PHOSPHOLIPASE A2 REDUCTION AMELIORATES COGNITIVE DEFICITS IN MOUSE MODEL OF ALZHEIMER’S DISEASE. Nature Neuroscience. 11(11): 1311–1318.Isolation and characterization of a low phytic acid rice mutant reveals a mutation in the rice orthologue of maize mik.-(Peer Reviewed Journal) Kim, S., Andaya, C.B., Newman, J.W., Goyal, S.S., Tai, T. 2008. ISOLATION AND CHARACTERIZATION OF A LOW PHYTIC ACID RICE MUTANT REVEALS A MUTATION IN THE RICE ORTHOLOGUE OF MAIZE MIK. Journal of Theoretical and Applied Genetics. 117(8):1291-301.INCREASED BLOOD PRESSURE IN MICE LACKING CYTOCHROME P450 2J5-(Peer Reviewed Journal) Athirakul, K., Bradbury, A.J., Graves, J.P., Degraff, L.M., Ma, J., Zhao, Y., Couse, J.F., Quigley, R., Harder, D.R., Zhao, X., Imig, J.D., Pedersen, T.L., Newman, J.W., Hammock, B.D., Conley, A.J., Korach, K.S., Coffman, T.M., Zeldin, D.C. 2008. INCREASED BLOOD PRESSURE IN MICE LACKING CYTOCHROME P450 2J5. Federation of American Societies for Experimental Biology Conference. 12):4096-108.DEVELOPMENT OF METABOLICALLY STABLE INHIBITORS OF MAMMALIAN MICROSOMAL EPOXIDE HYDROLASE-(Peer Reviewed Journal) Morisseau, C., Newman, J.W., Wheelock, C.E., Hill, Iii, T., Morin, D., Buckpitt, A.R., Hammock, B.D. 2008. Development of metabolically stable inhibitors of mammalian microsomal epoxide hydrolase. Chemical Research in Toxicology. 21:951-957.Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice.-(Peer Reviewed Journal) Wheelock, C.E., Forshed, J., Goto, S., Hammock, B.D., Newman, J.W. 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chemical Research in Toxicology. 21;583-590, 2008.SALT LOADING INCREASES URINARY EXCRETION OF LINOLEIC ACID DIOLS AND TRIOLS IN HEALTHY HUMAN SUBJECTS-(Peer Reviewed Journal) Driesbach, A.W., Rice, J.C., Japa, S., Newman, J.W., Sigel, A., Gill, R., Hess, A.E., Cemo, A.C., Fonseca, J.P., Hammock, B.D., Lertora, J., Hamm, J.P. Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects. 2008 Hypertension. 51:755-761.PATHOGENESIS OF ARYL HYDROCARBON RECEPTOR-MEDIATED DEVELOPMENT OF LYMPHOMA IS ASSOCIATED WITH INCREASED CYCLOOXYGENSE-2 EXPRESSION-(Peer Reviewed Journal) Vogel, C., Li, W., Sciullo, E., Newman, J.W., Hammock, B., Reader, R.J., Tuscano, J., Matsumura, F. Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygense-2 expression. 2007. American Journal of Pathology. Vol.171, No.5;1538-1548.CLOFIBRATE-INDUCED CHANGES IN THE LIVER, HEART, BRAIN AND WHITE ADIPOSE LIPID METABOLOME OF SWISS-WEBSTER MICE.-(Peer Reviewed Journal) Wheelock, C.S., Goto, S., Hammock, B.D., Newman, J.W. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of swiss-webster mice. Metabolomics 3(2):137-145, 2007.Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene disrupted mice-(Peer Reviewed Journal) Luria, A., Weldon, S.M., Kabcenell, A.K., Ingraham, R.H., Matera, D., Jiang, H., Gill, R., Morisseau, C., Newman, J.W., Hammock, B.D. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene disrupted mice. 2007. Journal of Biological Chemistry. Vol.282,No.5:12891-2898.Peptidyl-urea based inhibitors of soluble epoxide hydrolases-(Peer Reviewed Journal) Norisseau, C., Newman, J.W., Tsai, H., Baecker, P.A., Hammock, B.D. Peptidyl-urea based inhibitors of soluble epoxide hydrolases. 2006. Bioorganic and Medicinal Chemistry Letters. Vol.16: 5439-5444.ROLE OF SOLUBLE EPOXIDE HYDROLASE IN POST-ISCHEMIC RECOVERY OF HEART CONTRACTILE FUNCTION-(Peer Reviewed Journal) Seubert, J.M., Sinal, C.J., Graves, J.P., Degraff, L.M., Bradbury, A.J., Lee, C.R., Goralski, K.B., Carey, M.A., Luria, A., Newman, J.W., Hammock, B.D., Roberts, H., Rockman, H.A., Murphy, E., Zeldin, D.C. 2006. Role of soluble epoxide hydrolase in post-ischemic recovery of heart contractile function. Journal of Clinical Investigation. 2006. 99:442-450.Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study-(Peer Reviewed Journal) Lee, C.R., North, K.E., Bray, M.S., Fornage, M., Seubert, J.M., Newman, J.W., Hammock, B.D., Couper, D.J., Heiss, G., Zeldin, D.C. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Human Molecular Genetics. 15(10): 1640-1649, 2006.FATTY ACID PROFILES OF LIVER, ADIPOSE TISSUE, SPLEEN, AND HEART OF MICE FED DIETS CONTAINING T10, C-12-, AND C9, T11-CONJUGATED LINOLEIC ADIC-(Peer Reviewed Journal) Kelley, D.S., Bartolini, G.L., Newman, J.W., Vemuri, M., Mackey, B.E. 2006. FATTY ACID PROFILES OF LIVER, ADIPOSE TISSUE, SPLEEN, AND HEART OF MICE FED DIETS CONTAINING T10, C-12-, AND C9, T11-CONJUGATED LINOLEIC ADIC. Prostaglandins Leukotrienes and Essential Fatty Acids. 74:331-338.ATTENUATION OF VASCULAR SMOOTH MUSCLE CELL PROLIFERATION BY 1-CYCLOHEXYL-3-DODECYL UREA IS INDEPENDENT OF SOLUBLE EPOXIDE HYDROLASE INHIBITION.-(Peer Reviewed Journal) Davis, B.B., Morisseau, C., Pedersen, T., Newman, J.W., Hammock, B.D., Weiss, R.H. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition.. American Society of Pharmacology and Experimental Therapeutics. 2006: Vol.316, No.2:815-821.AN EPOXIDE HYDROLASE INHIBITOR, 12-(3-ADAMANTAN-1-YL-UREIDO) DODECANOIC ACID (AUDA), REDUCES ISCHEMIC CEREBRAL INFARCT SIZE IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS.-(Peer Reviewed Journal) Dorrance, A.M., Rupp, N., Pollock, D.M., Newman, J.W., Hammock, J.D., Imig, J.D. An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido) dodecanoic acid (auda), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. Journal Cardiovasc Pharmacol. 2005; 46(6):842-848.LIPID SULFATES AND SULFONATES ARE ALLOSTERIC COMPETITIVE INHIBITORS OF THE N-TERMINAL PHOSPHATASE ACTIVITY OF THE MAMMALIAN SOLUBLE EPOXIDE HYDROLASE-(Peer Reviewed Journal) Tran, K.L., Aronov, P.A., Tanaka, H., Newman, J.W., Hammock, B.D., Morisseau, C. Lipid sulfates and sulfonates are allosteric competitive inhibitors of the n-terminal phosphatase activity of the mammalian soluble epoxide hydrolase. Journal of Biochemistry. 44:12179-12187, 2005.AN ORALLY ACTIVE EPOXIDE HYDROLASE INHIBITOR LOWERS BLOOD PRESSURE AND PROVIDES RENAL PROTECTION IN SALT-SENSITIVE HYPERTENSION-(Peer Reviewed Journal) Imig, J.D., Zhao, X., Zaharis, C.Z., Olearczyk, J.J., Pollock, D.M., Newman, J.W., Kim, I.H., Watanabe, T., Hammock, B.D. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension. 2005;46(part 2):975-981.SOLUBLE EPOXIDE HYDROLASE IS A THERAPEUTIC TARGET FOR ACUTE INFLAMMATION-(Peer Reviewed Journal) Schmelzer, K.R., Kubala, L., Newman, J.W., Kim, I., Eiserich, J.P., Hammock, B.D. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Journal of the National Academy of Sciences. 102,9772-9777, 2005.THE GRADED EFFECTS OF PROTEINURIA ON HDL STRUCTURE IN NEPHROTIC RATS-(Peer Reviewed Journal) Shearer, G.C., Newman, J.W., Hammock, B.D., Kaysen, G.A. The graded effects of proteinuria on HDL structure in nephrotic rats. Journal of the American Society of Nephrology. 16: 1309-1319, 2005.  ProjectsImproving Public Health by Understanding Metabolic and Bio-Behavioral Effects of Following Recommendations in the Dietary Guidelines for AmericansIn-House Appropriated (D)Accession Number:436165UC Davis West Coast Metabolomics CenterNon-Funded Cooperative Agreement (N)Accession Number:444052Characterizing the Physiological Role of SLC22A24Reimbursable Cooperative Agreement (R)Accession Number:440289UC Davis Dietary Biomarkers Development Center - Metabolomics and Intervention CoresReimbursable Cooperative Agreement (R)Accession Number:441175Identifying the Role of Pulses in a Healthful Diet:  Metabolomic Signatures of Dietary Pulses and their Benefits on Cardiometabolic Risk FactorsNon-Assistance Cooperative Agreement (S)Accession Number:438943  ARS News ArticlesitemResearchers Analyze Metabolites in BlooditemPotential Indicators of Type 2 Diabetes InvestigateditemImproved Vitamin B12 Test May Help Young and Old Alike
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7/23/2020

    

    
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