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ARS Home Northeast Area Beltsville, Maryland (BHNRC) Beltsville Human Nutrition Research Center Diet, Genomics and Immunology Laboratory People & Locations







Jae B Park
                        Diet, Genomics and Immunology Laboratory

                        




                        
                        Research Chemist
                        Phone: (301) 504-8365
                         ext. 240
                        
                        Fax: (301) 504-9062(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            ProjectsImpact of Genetics, Growing Condition or Processing on Bioactive Components in Coffee and Microgreens: Influences on Health
                                                    In-House Appropriated
                                                                    (D)Accession Number: 445803Impact of Food and Particulates on Metabolic Risk
                                                    Non-Assistance Cooperative Agreement
                                                                    (S)Accession Number: 438888Biological Effects of Particles Generated by Biodiesel Fuels and Wildfires
                                                    Non-Assistance Cooperative Agreement
                                                                    (S)Accession Number: 445096**Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)Comparative Compositional Analysis of Regular and Decaf Coffees by LC/MS and HPLC and Potential Effects on Inflammatory Cytokines Produced during Bacterial Infections.
                                                        

- (Peer Reviewed Journal)Park, J.B., Peters, R.C., Pham, Q., Wang, T.T. 2024. Comparative compositional analysis of regular and decaf coffees by LC/MS and HPLC and potential effects on inflammatory Cytokines produced during bacterial infections. Food & Function. https://doi.org/10.1021/acsfoodscitech.3c00599.Methyl 2-[3-(4-hydroxyphenyl)prop-2-enoylamino]-3-phenylpropanoate is a potent cell-permeable anti-cytokine compound to inhibit inflammatory cytokines in monocyte/macrophage-like cells
                                                        

- (Peer Reviewed Journal)Park, J.B. 2024. Methyl 2-[3-(4-hydroxyphenyl)prop-2-enoylamino]-3-phenylpropanoate is a potent cell-permeable anti-cytokine compound to inhibit inflammatory cytokines in monocyte/macrophage-like cells. Journal of Pharmacology and Experimental Therapeutics. 388 (1) 181-189. https://doi.org/10.1124/jpet.123.001830.Impact of roasting on javamide-I/-II in Arabica and Robusta coffee beans
                                                        

- (Peer Reviewed Journal)Park, J.B., Peters, R.C., Novotny Dura, J. 2023. Impact of roasting on javamide-I/-II in Arabica and Robusta coffee beans. Food Chemistry. 412:135586. https://doi.org//10.1016/j.foodchem.2023.135586.Finding a cell-permeable compound to inhibit inflammatory cytokines: Uptake, biotransformation, and anti-cytokine activity of javamide-I/-II esters
                                                        

- (Peer Reviewed Journal)Park, J.B. 2022. Finding a cell-permeable compound to inhibit inflammatory cytokines: Uptake, biotransformation, and anti-cytokine activity of javamide-I/-II esters. Life Sciences. 291:120280. https://doi.org/10.1016/j.lfs.2021.120280.In vivo effects of coffee containing javamide-I/-II on body weight, LDL, HDL, total cholesterol, triglycerides, leptin, adiponectin, C-reactive protein, sE-selectin, TNF-alpha, and MCP-1
                                                        

- (Peer Reviewed Journal)Park, J.B. 2021. In vivo effects of coffee containing javamide-I/-II on body weight, LDL, HDL, total cholesterol, triglycerides, leptin, adiponectin, C-reactive protein, sE-selectin, TNF-alpha, and MCP-1. Current Developments in Nutrition. 6(1). https://doi.org/10.1093/cdn/nzab145.Soybean callus - a potential source of tocopherols
                                                        

- (Peer Reviewed Journal)Muresan, L., Clapa, D., Rusu, T., Wang, T.Y., Park, J.B. 2021. Soybean callus - a potential source of tocopherols. Plants. 10:2571. https://doi.org/10.3390/plants10122571.Potential impacts of soil tillage system on isoflavone concentration of soybean as functional food ingredients
                                                        

- (Peer Reviewed Journal)Muresan, L., Clapa, D., Borsal, O., Teodor, R., Wang, T.T., Park, J.B. 2020. Potential impacts of soil tillage system on isoflavone concentration of soybean as functional food ingredients. Land. 9(10):386. https://doi.org/10.3390/land9100386.Kahweol Found in Coffee Inhibits IL-2 Production Via Suppressing the Phosphorylations of ERK and c-Fos in Lymphocytic Jurkat Cells
                                                        

- (Peer Reviewed Journal)Park, J.B. 2020. Kahweol found in coffee inhibits IL-2 production via suppressing the phosphorylations of ERK and c-Fos in lymphocytic jurkat cells. Journal of Dietary Supplement. 18{1-11). https://doi.org/10.1080/19390211.2020.1784347.Javamide-II inhibits IL-6 without significant impact on TNF-alpha and IL-1beta in macrophage-like cells
                                                        

- (Peer Reviewed Journal)Park, J.B., Peters, R.C., Pham, Q., Wang, T.T. 2020. Javamide-II inhibits IL-6 without significant impact on TNF-alpha and IL-1beta in macrophage-like cells. BioMedical Journal. 8(6);138. https://doi.org/10.3390/biomedicines8060138.Concurrent HPLC detection of javamide-I/-II, caffeine, 3- O-caffeoylquinic acid, 4-O-caffeoylquinic acid and 5-O-caffeoylquinic acid; their comparative quantification and disparity in ground and instant coffees
                                                        

- (Peer Reviewed Journal)Park, J.B. 2019. Concurrent HPLC detection of javamide-I/-II, caffeine, 3- O-caffeoylquinic acid, 4-O-caffeoylquinic acid and 5-O-caffeoylquinic acid; their comparative quantification and disparity in ground and instant coffees. Separation Science Plus. 1-7. https://doi.org/10.1002/sscp.201900022.HPLC Quantification and MS/NMR confirmation of Javamide-I/-II in Arabica and Robusta coffee beans from different regions for finding better bean sources for Javamide-I/-II
                                                        

- (Peer Reviewed Journal)Park, J.B., Wang, T.T., Zhang, D., Vega, F.E., Meinhardt, L.W. 2019. HPLC Quantification and MS/NMR confirmation of Javamide-I/-II in Arabica and Robusta coffee beans from different regions for finding better bean sources for Javamide-I/-II. Austin Chromatography. 6(1):1051. https://doi.org/10.26420/austinchromatogrl.2019.1051.Javamide-II found in coffee suppresses TNF-alpha production more effectively than caffeine in PMA/PHA-treated lymphocytic Jurkat cells
                                                        

- (Peer Reviewed Journal)Park, J.B. 2018. Javamide-II found in coffee suppresses TNF-alpha production more effectively than caffeine in PMA/PHA-treated lymphocytic Jurkat cells. Journal of Agricultural and Food Chemistry. 66(26):6782-6789. https://doi.org/10.1021/acs.jafc.8b01885.In silico screening and in vitro activity measurement of javamide analogues as potential p38 MAP kinase inhibitors.
                                                        

- (Peer Reviewed Journal)Park, J.B. 2017. In silico screening and in vitro activity measurement of javamide analogues as potential p38 MAP kinase inhibitors. International Journal of Molecular Sciences. 18(12)pii:E2704. https://doi.org/10.3390/ijms ijms18122704.NMR confirmation and HPLC quantification of javamide-I and -II in green coffee products available in the market
                                                        

- (Peer Reviewed Journal)Park, J.B. 2017. NMR confirmation and HPLC quantification of javamide-I and -II in green coffee products available in the market. International Journal of Analytical Chemistry. 1927983. https://doi.org/10.1155/2017/1927983.Reactive oxidative species formation and unregulated particulate emissions from blended diesel and biodiesel light-duty engine emissions

- (Peer Reviewed Journal)Park, J.B. 2017. Reactive oxidative species formation and unregulated particulate emissions from blended diesel and biodiesel light-duty engine emissions. Journal of Environmental Science and Technology. doi: 10.1021/acs.energyfuels.7b00698.Methyl (E)-(3,4-dihydroxyphenyl)acryloyl)tryptophanate can suppress MCP-1 expression by inhibiting p38 MAP kinase and NF-kB in LPS-stimulated differentiated THP-1 cells
                                                        

- (Peer Reviewed Journal)Park, J.B., Wang, T.T. 2017. Methyl (E)-(3,4-dihydroxyphenyl)acryloyl)tryptophanate can suppress MCP-1 expression by inhibiting p38 MAP kinase and NF-kB in LPS-stimulated differentiated THP-1 cells. European Journal of Pharmacology. 8(10):149-155.. https://doi.org/10.1016/j.ejphar.2017.07.006.N-caffeoyltryptomine, a potent anti-inflammatory phenolic amide, suppressed MCP-1 expression in LPS-stimulated THP-1 cells and rats fed with a high fat diet
                                                        

- (Peer Reviewed Journal)Park, J.B. 2017. N-caffeoyltryptomine, a potent anti-inflammatory phenolic amide, suppressed MCP-1 expression in LPS-stimulated THP-1 cells and rats fed with a high fat diet. International Journal of Molecular Sciences. 18(6). pii:E1148. https://doi.org/10.3390/ijms18061148.Javamide-I-O-methyl ester increases p53 acetylation and induces cell death via activating caspase 3/7 in monocytic THP-1 cells

- (Peer Reviewed Journal)Park, J.B. 2016. Javamide-I-O-methyl ester increases p53 acetylation and induces cell death via activating caspase 3/7 in monocytic THP-1 cells. Phytomedicine. 23(13):1647-1652. doi: 10.1016/j.phymed.2016.10.004.Activity-guided isolation of a sirtuin2 inhibiting compound from coffee: structural and activity confirmation of Javamide-II (N-caffeoyltryptophan)and its cellular effects on histone H3 and alpha-tubulin

- (Peer Reviewed Journal)Park, J.B. 2016. Activity-guided isolation of a sirtuin2 inhibiting compound from coffee: structural and activity confirmation of Javamide-II (N-caffeoyltryptophan)and its cellular effects on histone H3 and alpha-tubulin. PLoS One. 11(3):e0150392.Potential biological activities and bioavailability of alfrutamide and caffedymine

- (Peer Reviewed Journal)Park, J.B. 2016. Potential biological activities and bioavailability of alfrutamide and caffedymine. Journal of Nutrition. 146(2):437S-4435.Becatamide Found in Houttuynia cordata suppresses P-selectin expression via inhibiting COX enzyme, not increasing cAMP in platelets

- (Peer Reviewed Journal)Park, J.B. 2015. Becatamide found in Houttuynia cordata suppresses P-selectin expression via inhibiting COX enzyme, not increasing cAMP in platelets. Phytotherapy Research. DOI: 10.1002/ptr.5391Synthesis and characterization of norbelladine, a precursor of Amaryllidaceae alkaloid, as an anti-inflammatory/anti-COX compound

- (Peer Reviewed Journal)Park, J.B. 2014. Synthesis and characterization of norbelladine, a precursor of Amaryllidaceae alkaloid, as a potent anti-inflammatory/anti-COX compound. Bioorganic and Medicinal Chemistry Letters. 1:24(23):5381-5384.Potential effects of chlorogenic acids on platelet activiation
                                                        

- (Book / Chapter)Park, J.B. 2014.  Potential effects of chlorogenic acids on platelet activiation. In: Preedy, V.R., editor. Coffee in Health and Disease. Academic Press. Amersterdam, Boston, New York. Book Chapter. p709-715.Synthesis, HPLC measurement and bioavailability of the phenolic amide amkamide

- (Peer Reviewed Journal)Park, J.B. 2013. Synthesis, HPLC measurement and bioavailability of the phenolic amide amkamide. Journal of Chromatographic Science. DOI: 10.1093/chromsci/bmt055. Epub 2013 May 27..Flaxseed lignan and visceral obesity: a closer look at its chemical properties, absorption, metabolism, bioavailability and effects on visceral fat, lipid profile, systemic inflammation and hypertension

- (Book / Chapter)Park, J.B. 2014. Flaxseed lignan and visceral obesity: a closer look at its chemical properties, absorption, metabolism, bioavailability and effects on visceral fat, lipid profile, systemic inflammation and hypertension.  In: Watson, R.R., Academic Press.  Nutrition in the Prevention and Treatment of Abdominal Obesity. 1st edition.  San Diego, CA: Academic Press. p317-328.Isolation and quantification of major chlorogenic acids in three major instant coffee brands and their potential effects on H2O2-induced mitochondrial membrane depolarization and apoptosis in PC-12 cells

- (Peer Reviewed Journal)Park, J.B. 2013. Isolation and quantification of major chlorogenic acids in three major instant coffee brands and their potential effects on H2O2-induced mitochondrial membrane depolarization and apoptosis in PC-12 cells. Food and Function. 4(11):1632-1638Food Funct. doi: 10.1039/c3fo60138b..Synthesis, biological activity, and bioavailability of moschamine, a safflomide-type phenylpropenoic acid amide found in Centaurea cyanus

- (Peer Reviewed Journal)Park, J.B. 2012. Synthesis, biological activity, and bioavailability of moschamine, a safflomide-type phenylpropenoic acid amide found in Centaurea cyanus. Natural Product Research. 26(16):1465-72.Effects of secoisolariciresinol diglucoside lignan-enriched flaxseed powder on body weight, visceral fat, lipid profile, adipokines, and blood pressure in rats fed a high-fructose and high-fat diet

- (Peer Reviewed Journal)Park, J.B., Velasquez, M.T. 2012. Effects of secoisolariciresinol diglucoside lignan-enriched flaxseed powder on body weight, visceral fat, lipid profile, adipokines, and blood pressure in rats fed a high-fructose and high-fat diet. Fitoterapia. 83(5):941-6.Safflomide increases the expression of adiponectin in vitro and in vivo: Implication for hypoadiponectemia, visceral obesity, and insulin resistance

- (Peer Reviewed Journal)Park, J.B., Wang, T.T. 2012. Safflomide increases the expression of adiponectin in vitro and in vivo: Implication for hypoadiponectemia, visceral obesity, and insulin resistance. Journal of Agricultural and Food Chemistry. 25(60):4048-52.Identification and quantification of a major anti-oxidant and anti-inflammatory phenolic compound found in basil, lemon, thyme, mint, oregano, rosemary, sage, and thyme

- (Peer Reviewed Journal)Park, J.B. 2011. Identification and quantification of a major anti-oxidant and anti-inflammatory phenolic compound found in basil, lemon, thyme, mint, oregano, rosemary, sage, and thyme. International Journal of Food Sciences and Nutrition. 62(6):577-584.Protective effects of veskamide, enferamide, becatamide, and oretamide on H2O2-induced apoptosis of PC-12 cells

- (Peer Reviewed Journal)Park, J.B. 2011. Protective effects of veskamide, enferamide, becatamide, and oretamide on H2O2-induced apoptosis of PC-12 cells. Phytomedicine. 18(10):843-847.Isolation and characterization of N-feruloyltyramine as the P-selectin expression suppressor from garlic (Allium sativum)

- (Peer Reviewed Journal)Park, J.B. 2009. Isolation and characterization of N-feruloyltyramine as the P-selectin expression suppressor from garlic (Allium sativum). Journal of Agricultural Food & Chemistry. 57(19):8868-8872.Serotomide and Safflomide Modulate Forskolin-Stimulated cAMP Formation via 5-HT1 Receptor

- (Peer Reviewed Journal)Park, J.B. 2008. Serotomide and safflomide modulate forskolin-stimulated cAMP formation via 5-HT1 receptor. Phytomedicine. http://dx.doi.org/10.1016/j.phymed.2008.04.009.5-Caffeoylquinic acid and caffeic acid orally administered suppresses P-selectin expression on mouse platelets

- (Peer Reviewed Journal)Park, J.B. 2008. 5-Caffeoylquinic acid and caffeic acid orally administered suppresses P-selectin expression on mouse platelets. Journal of Nutritional Biochemistry. 20(10):800-805. Available http://dx.doi.org/10.1016/j.jnutbio.2008.07.009.Caffedymine from cocoa has COX inhibitory activity suppressing the expression of a platelet activation marker, P-Selectin

- (Peer Reviewed Journal)Park, J.B. 2007. Caffedymine from cocoa has COX inhibitory activity suppressing the expression of a platelet activation marker, P-selectin. Journal of Agricultural and Food Chemistry.(6):2171-5.Synthesis of safflomide and its HPLC measurement in mouse plasma after oral administration

- (Peer Reviewed Journal)Park, J.B., Chen, P. 2007. Synthesis of safflomide and its HPLC measurement in mouse plasma after oral administration. Journal of Chromatography B: Biomedical Applications. 852(1-2):398-402.CLOVAMIDE-TYPE PHENYLPROPENOIC ACID AMIDES, N-COUMAROYLDOPAMINE AND N-CAFFEOYLDEPAMINE, INHIBIT PLATELET-LEUKOCYTE INTERACTIONS VIA SUPPRESSING P-SELECTIN EXPRESSION

- (Peer Reviewed Journal)Park, J.B., Schoene, N.W. 2006. Clovamide-type phenylpropenoic acid amides, n-coumaroyldopamine and n-caffeoyldepamine, inhibit platelet-leukocyte interactions via suppressing p-selectin expression. Journal of Pharmacology and Experimental Therapeutics.  317(2):813-819.QUANTITATION OF CLOVAMIDE-TYPE PHENYLPROPENIC ACID AMIDES IN CELLS AND PLASMA USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH A COULOMETRIC ELECTROCHEMICAL DETECTOR

- (Peer Reviewed Journal)Park, J.B. 2005. Quantitation of clovamide-type phenylpropenic acid amides in cells and plasma using high performance liquid chromatography with a coulometric electrochemical detector. Journal of Agricultural and Food Chemistry. 53:8135-8140.QUERCITIN

- (Book / Chapter)Park, J.B. 2005. Quercetin. In: Coates, P., Blackman, M.R., Cragg, G., Levine, M., Moss, J., White, J., editors. Encyclopedia of Dietary Supplements. New York, NY. Marcell Dekker Press. p. 577-585.N-COUMAROYLDOPAMINE AND ITS ANALOGUES FOUND IN COCOA (THEOBROMA CACAO L.) ARE POTENT BETA-ADRENOCEPTOR AGONISTS SUPPRESSING PLATELET ACTIVITION VIA INCREASING CAMP PRODUCTION.

- (Abstract Only)Park, J.B. 2005. N-coumaroyldopamine and its analogues found in cocoa (theobroma cacao l.) are potent beta-adrenoceptor agonists suppressing platelet activition via increasing camp production. [Abstract]. Experimental Biology 566(2): 566.PHENYLPROPENIC ACID AMIDE, N-CAFFEOYLTYRAMINE, INCREASES CAMP VIA BETA 2-ADRENOCEPTORS IN HUMAN MONOCYTIC U937 CELLS; ITS EFFECTS ON MONOCYTE ACTIVATION

- (Abstract Only)Park, J.B., Schoene, N.W. 2005. Phenylpropenic acid amide, n-caffeoyltyramine, increases camp via beta 2-adrenoceptors in human monocytic u937 cells; its effects on monocyte activation. [Abstract]. Experimental Biology 830(5):830.N-COUMAROYLDOPAMINE AND N-CAFFEOYLDEPAMINE INCREASE CAMP VIA BETA 2-ADRENOCEPTORS IN MYCLOCYTIC U937 CELLS

- (Peer Reviewed Journal)Park, J.B. 2005. N-coumaroyldopamine and n-caffeoyldepamine increase camp via beta 2-adrenoceptors in myelocytic U937 cells. Federation of American Societies for Experimental Biology Journal. 19:497-502.CLONING, SEQUENCING, AND CHARACTERIZATION OF ALTERNATIVELY SPLICED GLUTAREDOXIN CDNA AND ITS GENOMIC GENE

- (Peer Reviewed Journal)Park, J.B., Levin, M. 2005. Cloning, sequencing, and characterization of alternatively spliced glutaredoxin cDNA and its genomic gene. Journal of Biological Chemistry. 280:10427-10434.A PHENYLPROPENOIC ACID DERIVATIVE, N-CAFFEOLYTYRAMINE, IS A POTENT PHYTOCHEMICAL TO INDUCE APOPTOSIS OF HUMAN TRANSFORMED MYEOLOCYTIC U937 AND HL-60 AND LYMPHOCYTIC JURKAT CELLS

- (Peer Reviewed Journal)Park, J.B., Schoene, N.W. 2003. A phenylpropenoic acid derivative, n-caffeolytyramine, is a potent phytochemical to induce apoptosis of human transformed myeolocytic u937 and hl-60 and lymphocytic jurkat cells. Journal of Natural Products.FLAVONOID INHIBITION OF THE INTESTINAL VITAMIN C TRANSPORTER SVCT1(H)

- (Peer Reviewed Journal)N-COUMAROYLTYRAMINE IS A POTENT PHYTOCHEMICAL TO ARREST MEYLOCYTIC U937 AND LYMPHOCYTIC JURKAT CELLS AT THE S PHASE OF CELL CYCLE

- (Peer Reviewed Journal)Park, J.B., Schoene, N.W. 2003. N-coumaroyltyramine is a potent phytochemical to arrest meylocytic u937 and lymphocytic jurkat cells at the s phase of cell cycle. Cancer Letters. 202:161-171.CONCURRENT MEASUREMENTS OF PROMOTER ACTIVITY AND TRANSFECTION EFFICIENCY   USING A NEW REPORT VECTOR CONTAINING BOTH PHOTINUS PYRALIS AND RENILLA     RENIFORMIS LUCIFERARE GENES

- (Peer Reviewed Journal)REDUCTION OF DEHYDROASCORBIC ACID BY HOMOCYSTEINE

- (Peer Reviewed Journal)INTRACELLULAR ACCUMULATION OF ASCORBIC ACID IS INHIBITED BY FLAVONOIDS     VIA BLOCKING OF DEHYOHROASCORBIC ACID AND ASCORBIC ACID UPTAKES IN HL-60,  U937, AND JARKAT CELLS.

- (Peer Reviewed Journal)FLAVONOIDS ARE THE POTENTIAL INHIBITORS OF THE GLUCOSE UPTAKE IN U937

- (Peer Reviewed Journal)CRITERIA AND RECOMMENDATIONS FOR VITAMIN C INTAKE

- (Peer Reviewed Journal)
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