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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-K/A

(Amendment No. 1)







|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended December 31, 2015

OR



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from
 to

Commission File number 1-10352





Juniper
Pharmaceuticals, Inc.

(Exact name of registrant as specified in its charter)







|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 59-2758596                          
|(State or other jurisdiction of
incorporation or organization) |  | (I.R.S. Employer
Identification No.)



|                                                                                                             |  |           
|------------------------------------------------------------------------------------------------------------ |  | ----------
|33 Arch Street
Boston, Massachusetts                                                                         |  | 02110     
|(Address of principal executive offices)
 Registrants telephone number, including area
code: (617) 639-1500 |  | (Zip Code)

Securities registered pursuant to Section 12(b) of the Act:



|                             |  |                                       
|---------------------------- |  | --------------------------------------
|Common Stock, $.01 par value |  | NASDAQ Capital Market                 
|(Title of each class)        |  | (Name of exchange on which registered)

Securities registered pursuant to Section 12(g) of the Act: None





Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities
Act.    Yes   ̈    No  x

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the
Act.    Yes   ̈    No  x

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  x    No   ̈

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive
Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such
files).    Yes  x    No   ̈

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K (§229.405 of this chapter) is not
contained herein, and will not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form
10-K.     ̈

Indicate by check mark whether the registrant is a large
accelerated filer, an accelerated filer or a non-accelerated filer or a smaller reporting company. See the definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2
of the Exchange Act.



|                        |  |   |  |                           |  |  
|----------------------- |  | - |  | ------------------------- |  | -
|Large accelerated filer |  |  ̈ |  | Accelerated filer         |  | x
|                        |  |   | 
|Non-accelerated filer   |  |  ̈ |  | Smaller reporting company |  |  ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the
Act).    Yes   ̈    No  x

The aggregate market value of Common Stock held by non-affiliates of the registrant on June 30, 2015, the last business day of the
registrants most recently completed second fiscal quarter, based on the adjusted closing price on that date of $9.15, was $92,533,227.

Number of shares of Common Stock of Juniper Pharmaceuticals, Inc. issued and outstanding as of March 7, 2016 is 10,801,549.

Explanatory Note

The
purpose of this amendment is to include the information required by Part III of Form 10-K, which was omitted from Juniper Pharmaceutical, Inc.s Annual Report on Form 10-K for the fiscal year ended December 31, 2015, as originally filed on
March 10, 2016. Except as otherwise expressly set forth in this amendment, no portion of the Annual Report on Form 10-K filed on March 10, 2016 is being amended or updated by this amendment.









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Table of contents



|           |  |                                                                                                 |    |      |    | 
|---------- |  | ----------------------------------------------------------------------------------------------- | -- | ---- | -- | 
|           |  |                                                                                                 |    | Page |   
|Part III   |  |                                                                                                 |    |      | 3  | 
|           |  |                                                                                                
|Item 10    |  | Directors, Executive Officers and Corporate Governance                                          |    |      | 3  | 
|Item 11    |  | Executive Compensation                                                                          |    |      | 8  | 
|Item 12    |  | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder
 Matters |    |      | 29 | 
|Item 13    |  | Certain Relationships and Related Transactions and Director Independence                        |    |      | 31 | 
|Item 14    |  | Principal Accountant Fees and Services                                                          |    |      | 31 | 
|           |  |                                                                                                
|Part IV    |  |                                                                                                 |    |      | 32 | 
|           |  |                                                                                                
|Item 15    |  | Exhibits and Financial Statement Schedules                                                      |    |      | 32 | 
|           | 
|SIGNATURES |  |                                                                                                 | 36 |     



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PART III



|Item 10. | Directors, Executive Officers and Corporate Governance
|-------- | ------------------------------------------------------

The Board in General

Our board of
directors (the Board) is currently comprised of seven members, each of whose current term of office as a director expires at our 2016 annual meeting of stockholders. The Board can fill vacancies and newly created directorships, as well
as provide for a greater or lesser number of directors.

Biographical information with respect to our directors is provided in the table
below.

There are no arrangements or understandings between any of our directors and any other persons pursuant to which such directors
was selected as a director. There are no family relationships among any of the executive officers and directors of the Company.



|                       |  |                                      |  |     |    |  |                |  |      | 
|---------------------- |  | ------------------------------------ |  | --- | -- |  | -------------- |  | ---- | 
|Name                   |  | Position with the Company            |  | Age |    |  | Director Since | 
|Dr. Frank M. Armstrong |  | Director                             |  |     | 59 |  |                |  | 2013 | 
|Frank C. Condella, Jr. |  | Director and Chief Executive Officer |  |     | 61 |  |                |  | 2009 | 
|Dr. Cristina Csimma    |  | Director                             |  |     | 57 |  |                |  | 2010 | 
|James A. Geraghty      |  | Chairman of the Board                |  |     | 61 |  |                |  | 2015 | 
|Dr. Mary Ann Gray      |  | Director                             |  |     | 63 |  |                |  | 2016 | 
|Ann Merrifield         |  | Director                             |  |     | 65 |  |                |  | 2015 | 
|Dr. Nikin Patel        |  | Director and Chief Operating Officer |  |     | 43 |  |                |  | 2013 | 

Dr. Frank M. ArmstrongFRCPE, FFPM has been a director of the Company since September 2013. Dr.
Armstrong led Medical Science and Innovation in R&D at Merck Serono from December 2010 to December 2011 and previously led Worldwide Product Development at Bayer AG from 1998 to 2001 and the Worldwide Medical Organization at Zeneca from 1996 to
1998. He also served as Chief Executive Officer of Fulcrum Pharma plc (professional services/CRO) from 2008 to 2010; President and Chief Executive Officer of CuraGen Corp. (oncology therapeutics) from 2006 to 2007; Chief Executive Officer of
Bioaccelerate from 2005 to 2006; Chief Executive Officer of Provensis Pharmaceuticals, a subsidiary of BTG PLC (healthcare) from 2003 to 2004; and Chief Executive Officer of Phoqus Pharmaceuticals plc. (drug delivery) from 2002 to 2003. Dr.
Armstrong holds an honours degree and MBChB in Biochemistry and Medicine from the University of Edinburgh in Scotland. He was elected as a Fellow of the Faculty of Pharmaceutical Physicians (FFPM) in 1994, and Fellow of Royal College of Physicians,
Edinburgh (FRCPE) in 1993. Dr. Armstrong is currently the non-executive Chairman of Caldan Therapeutics, a position he has held since February 2016; the non-executive Chairman of Faron Pharmaceuticals, a position he has held since September 2015; a
non-executive Director for Mereo Pharma, a position he has held since April 2015; the non-executive Chairman of Summit plc (drug discovery and development), a position he has held since June 2013; Chairman of Xceleron Inc. (bioanalytical services),
a position he has held since April 2012; and a non-executive Director of Actino Pharma, a position he has held since November 2009. He is also a member of the Strategic Advisory Board of Healthcare Royalty Partners, a position he has held since 2009
and Chairman of the U.K.- based Love Africa Charitable Trust, a position he has held since 2009.

Qualifications: Dr. Armstrong is an experienced, medically qualified, pharmaceutical executive with over 20 years of experience
in development and management at major pharmaceutical and leading biotechnology companies in the U.K., U.S., Switzerland and Germany. Dr. Armstrongs experience spans all aspects of the drug evaluation, development and commercialization
processes.



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Frank C. Condella, Jr.has served as Chief Executive Officer since December 2009 and has
been a Director of Juniper since March 2009. Mr. Condella has over 30 years of experience in the pharmaceutical industry. He was Chief Executive Officer of Skyepharma plc from March 2006 to September 2008, President of European Operations and
Managing Director, UK at IVAX Corporation from 2002 to February 2006, and President and Chief Executive Officer of Faulding Pharmaceuticals, Vice-President of Specialty Care Products at Roche and Vice-President and General Manager of Lederle
(Pfizer) Standard Products. Mr. Condella is currently the non-executive Chairman of Skyepharma plc, and Vice Chairman of the Board of Trustees of the PKD Foundation. Mr. Condella holds a MBA degree and a B.S. degree in pharmacy from Northeastern
University.

Qualifications: Mr. Condella has a wide-ranging business background, including senior leadership roles in the
pharmaceutical and healthcare industry, with particular experience in marketing, sales, manufacturing, product development, licensing and acquisitions.

Dr. Cristina Csimma, PharmD, MHPhas been a director of the Company since September 2010. She is also a director of Vtesse Inc., a rare
disease company, and has been engaged in strategic advisory roles with the biopharmaceutical and venture capital industries, as well as government and patient organizations. Dr. Csimma has been a President and the founding Chief Executive Officer of
Cydan Development, Inc. (therapeutics for orphan diseases) from November 2012 until April 2014, and a director of the company until December 2014. Prior to that she served as Vice President, Drug Development, of Virdante Pharmaceuticals, Inc., from
January 2009 to May 2011. She was a principal of Clarus Ventures, LLC (life sciences venture capital) from 2006 through 2008. She was Senior Director/Director, Experimental Medicine and Translational Research, Wyeth Research (pharmaceuticals) from
2001 to 2006, and Director, Clinical Research and Development, Wyeth Research (pharmaceuticals) from 2000 to 2001. Previously, Dr. Csimma held various positions, including Associate Director, Clinical Research, with Genetics Institute from 1988 to
2000, and was a Clinical Pharmacist with Dana-Farber Cancer Institute from 1983 to 1988. Dr. Csimma holds B.S. and Doctor of Pharmacy degrees from the Massachusetts College of Pharmacy and Allied Health Sciences, and a Master of Health Professions
from Northeastern University.

Qualifications: Dr. Csimma has extensive experience in drug development, fund raising and
company building in the biopharmaceutical industry, and venture capital, and has led global programs in multiple therapeutic areas.

James A. Geraghty has served as the Chairman of the Board since May 2015. Since May 2013, Mr. Geraghty has served as an
Entrepreneur in Residence at Third Rock Ventures, a leading biotech venture and company-formation fund. From April 2011 to December 2012, Mr. Geraghty served as Senior Vice President, North America Strategy and Business Development at
Sanofi, which he joined upon its acquisition of Genzyme. Mr. Geraghty spent the 20 prior years at Genzyme, where his roles included Senior Vice President International Development, President of Genzyme Europe, and General Manager of
Genzymes cardiovascular business. Mr. Geraghty has served as Chairman of the Board of Idera Pharmaceuticals (biotechnology) since 2013 and as a member of the board of directors of Voyager Therapeutics, Inc. since 2014. Mr. Geraghty
is also a member of the Joslin Diabetes Center Board of Trustees, and of the BIO Ventures for Global Health board. He started his career in healthcare strategy consulting at Bain and Company. A graduate of the Yale Law School, Mr. Geraghty
holds a M.S. from the University of Pennsylvania and a B.A. from Georgetown University.

Qualifications: Mr. Geraghty
is an industry leader with 30 years of strategic and leadership experience, including more than 20 years as a senior member of executive teams at biotechnology companies developing and commercializing innovative therapies.

Dr. Mary Ann Gray has been a director of the Company since March 2016. Since 2003, Dr. Gray has served as President of Gray Strategic
Advisors, LLC, which provides strategic advice to both public and private biotechnology companies. Previously, she spent three and a half years with the Federated Kaufmann Fund focusing on both public and private healthcare
investments. Prior to joining the Kaufmann Fund, Dr. Gray was a sell-side biotechnology analyst for nine years with Kidder Peabody, Dillon Read and Raymond James. She also held



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scientific positions at Schering Plough and NeoRx. Dr. Gray has also served on the board of directors of three public biotechnology companies, Acadia Pharmaceuticals, Inc. (Acadia)
since 2005, Senomyx, Inc. (Senomyx) since 2010, and TetraLogic Pharmaceuticals Corporation (TetraLogic), since 2014. At Acadia she serves as chairman of the audit committee and also serves on the compensation committee. At
Senomyx she is a member of the compensation committee. At TetraLogic she is chairman of the audit committee. Dr. Gray also served on the board of directors of Dyax Corp., beginning in 2001, and served as its lead director from 2010 until January
2016, when Dyax Corp. was acquired by Shire plc. Dr. Gray has a Ph.D. in Pharmacology from the University of Vermont where she focused on novel chemotherapeutic agents for the treatment of cancer. She did post-doctoral work at Northwestern
University Medical School and Yale University School of Medicine. Earlier in her career, Dr. Gray managed pre-clinical toxicology studies for the National Cancer Institute through Battelle Memorial Institute and worked in hospital laboratory.

Qualifications: Dr. Gray has a strong dual background as a scientist and financial analyst and portfolio manager in the
biotechnology industry, as well as public company board experience.

Ann Merrifield has been a director of the Company since July
2015. She was previously the President and Chief Executive Officer of genomics company, PathoGenetix, Inc., a privately held health technology company, from December 2012 to July 2014. Prior to joining PathoGenetix, Inc., Ms. Merrifield served an
18-year tenure at Genzyme Corporation (now owned by Sanofi S.A.), a diversified, global biotechnology company. During her time at Genzyme Corporation, Ms. Merrifield served, among other roles, as Senior Vice President, Business Excellence, President
of Genzyme Biosurgery, and President of Genzyme Genetics. Prior to joining Genzyme, Ms. Merrifield was a Partner at Bain and Company, a global strategy consulting firm, and an Investment Officer at Aetna Life & Casualty. Ms. Merrifield earned a
Bachelor of Arts in Zoology and a Master of Education from the University of Maine, and a Master of Business Administration from the Amos Tuck School of Business at Dartmouth College. She is also a Director of Flexion Therapeutics and InVivo
Therapeutics, and a Trustee of two MassMutual investment funds.

Qualifications: Ms. Merrifield has broad expertise in
the biotechnology sector and extensive management experience.

Dr. Nikin Patelhas served as our Chief Operating Officer since
April 2015. Dr Patel co-founded and served as the Chief Executive Officer of Juniper Pharma Services (f/k/a Molecular Profiles, Ltd.) from 1998 until April 2015. He has served as President of Juniper Pharma Services since April 2015. Dr.
Patel joined our board of directors in September 2013, when Juniper Pharma Services was acquired by us. Dr. Patel has over 15 years technical experience centered on pharmaceutical analysis and formulation development. His leadership was
recognized externally through the U.K.s most prestigious industry accolade, the Queens Award for Enterprise, won by Molecular Profiles in both 2007 and 2011 in the Innovation category.

Qualifications: Dr. Patel holds a first class honours degree and PhD in Pharmacy from the University of Nottingham, and is a
Member of the Royal Pharmaceutical Society (MRPharmS). Dr. Patel is also a co-founder of Locate Therapeutics, a specialist regenerative medicine and device company.

Executive Officers

Our Executive
Officers as of the date of this report are as follows:



|                       |  |     |  |                                      
|---------------------- |  | --- |  | -------------------------------------
|Name                   |  | Age |  | Position with the Company            
|Frank C. Condella, Jr. |  | 61  |  | President and Chief Executive Officer
|George O. Elston       |  | 51  |  | Chief Financial Officer              
|Dr. Nikin Patel        |  | 43  |  | Chief Operating Officer              
|Dr. Bridget Martell    |  | 50  |  | Chief Medical Officer                



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Officers serve at the discretion of the Board. There is no family relationship between any of
the executive officers or between any of the executive officers and the Companys directors. There is no arrangement or understanding between any executive officer and any other person pursuant to which the executive officer was selected.

Frank C. Condella, Jr.For Mr. Condellas biography, please see above under The Board in General.

George O. Elston.Mr. Elston has served as our Chief Financial Officer since September 2014.Mr. Elston has over 20 years
of experience as a senior financial executive. Prior to joining the Company, Mr. Elston was the Senior Vice President and Chief Financial Officer of KBI Biopharma, Inc., a contract research firm to the biopharmaceutical industry, from February 2013
through September 2014. He has served as the Managing Partner of Chatham Street Partners, a strategic advisory firm to the life science industry since January 2010. From January 2008 to January 2010, Mr. Elston was Chief Financial Officer of
Optherion, Inc., a privately held biopharmaceutical company. From May 2000 to September 2007, Mr. Elston held several senior executive roles at Elusys Therapeutics, Inc., a privately held biopharmaceutical company. Before joining Elusys, Mr. Elston
was Chief Financial Officer of Trillium USA, Inc., prior to which, he was with C.R. Bard, Inc., an international manufacturer and distributor of medical devices, and with PricewaterhouseCoopers. Mr. Elston has served on the board of directors of
Celldex Therapeutics, Inc. since 2004, which became a public reporting company in 2008, and has been Chairman of its audit committee since 2004. He has also served as a trustee for the Deutsche Bank DBX ETF Trust since October 2010, where he also
serves as Chairman of the audit committee. He received his B.B.A in Public Accounting from Pace University and is a Certified Public Accountant.

Dr. Nikin Patel. For Dr. Patels biography, please see above under The Board in General.

Dr. Bridget Martell.Dr. Martell has served as our Chief Medical Officer since January 2015. Dr. Martell
brings more than15 years experience in clinical development, medical affairs and academia to the Company, including expertise in
establishing regulatory strategy for clinical programs and creating submission readiness packages. She has overseen the product development activities of numerous
pharmaceutical companies, including Purdue Pharma and several business units within Pfizer Worldwides biopharmaceutical business. At Purdue Pharma, where she served
from October 2011 to April 2013, Dr. Martell led and built a new medical affairs organization to support the in-line and developing medications portfolio. Prior to
her time at Purdue Pharma, Dr. Martell was the Biosimilars medical head at Pfizer, where she served from August 2010 to August 2011, responsible for clinical development and
medical affairs activities. She also held senior clinical development roles in other business units within Pfizers biopharmaceutical business. Most recently, Dr.
Martell was the founder and managing director of BAM Consultants. Dr. Martell holds a Bachelors of Science in Microbiology from Cornell University, a Master of Arts in Molecular Immunology from Boston University,
and a Doctor of Medicine degree from The Chicago Medical School. She completed her internship and residency in Internal Medicine, was a Chief Resident, and a Robert Wood Johnson Clinical Scholar at Yale University School of Medicine. She is board
certified in both Internal and Addiction Medicine.

Audit Committee

The current members of our Audit Committee are Dr. Mary Ann Gray (Chair), Dr. Frank M. Armstrong, and James A. Geraghty. Each of
these individuals has been determined by the Board to be independent within the meaning of applicable Securities and Exchange Commission (SEC) rules and NASDAQ Marketplace Rules.

The committee meets at regularly scheduled times during the year and on an ad hoc basis as business needs necessitate. In 2015 the
committee held 9 meetings. The primary function of the Audit Committee is to oversee Junipers reporting processes on behalf of the Board and to report the results of its activities to the Board. The Audit Committees primary duties and
responsibilities are to:



| |  |  | Serve as an independent and objective party to monitor the Companys financial reporting process, including
the review of the financial reports and other financial information provided by the
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | Company to governmental or regulatory bodies, the public or other users, and internal control systems (including any material weaknesses, significant deficiencies and significant changes in
internal controls reported to the Audit Committee by the outside auditor or management);
| | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Approve the engagement of the Companys independent registered public accounting firm;
| | - |  | --------------------------------------------------------------------------------------



| |  |  | Review and appraise the audit efforts of the Companys independent registered public accounting firm;
| | - |  | -----------------------------------------------------------------------------------------------------



| |  |  | Provide an open avenue of communication among the Companys independent registered public accounting firm and financial and senior management of the Company;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Review financial press releases;
| | - |  | --------------------------------



| |  |  | Review and address conflicts of interests of the Companys directors and executive officers;
| | - |  | --------------------------------------------------------------------------------------------



| |  |  | Review materials to identify and address the status of major risks to the Company; and
| | - |  | --------------------------------------------------------------------------------------



| |  |  | Monitor, review, and recommend actions relating to transactions and dealings with related parties.
| | - |  | --------------------------------------------------------------------------------------------------

The Audit Committee acts pursuant to the Audit Committee Charter. While the Audit Committee has the powers and responsibilities set forth in
its charter, it is not the responsibility of the Audit Committee to plan or conduct audits, or to determine that Junipers financial statements are complete and accurate or are in compliance with generally accepted accounting principles. This
is the responsibility of management and the Companys independent registered public accounting firm.

All of the members of the Audit
Committee have been determined by the Board to be independent within the meaning of the applicable Nasdaq Marketplace Rules and Section 10A-3(b)(1) of the Exchange Act of 1934, as amended (the Exchange Act). The Company has
identified Dr. Gray as an audit committee financial expert as that term is defined under applicable regulations of the SEC.

Code of
Business Conduct and Ethics

The Board has adopted a Code of Business Conduct and Ethics that applies to all of our directors,
executive officers (including our Chief Executive Officer and our Chief Financial Officer), and employees of the Company. Our Code of Business Conduct and Ethics is posted on our corporate website, www.juniperpharma.com.We will provide an
electronic or paper copy of this document free of charge upon request. If, in the future, we should amend our Code of Business Conduct and Ethics or grant a waiver to our Chief Executive Officer or our Chief Financial Officer and principal
accounting officer with respect to our Code of Business Conduct and Ethics, then we will post the amendment or a description of the waiver in the Investor section of our corporate website, www.juniperpharma.com,or in a Current
Report on Form 8-K.

Section 16(a) Beneficial Ownership Reporting Compliance

Section 16(a) of the Exchange Act, and the rules issued thereunder, requires our directors and executive officers and beneficial owners of
more than 10% of the outstanding shares of our equity securities to file reports of ownership and changes in beneficial ownership of our equity securities with the SEC. Copies of these reports are furnished to the Company. The Company is required to
identify any of those individuals who failed to file such reports on a timely basis. Based solely on our review of the copies of such reports furnished to us, and representations from the persons subject to Section 16(a) of the Exchange Act with
respect to our Company, we believe that during 2015 all of our executive officers, directors and 10% stockholders complied with the Section 16(a) requirements except that Mr. Geraghty filed one late Form 4 reporting one transaction and Ms.
Merrifield filed a late Form 3.



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|Item 11. | Executive Compensation
|-------- | ----------------------

Compensation Discussion and
Analysis

Introduction

Our Compensation Committee provides assistance to the Board in fulfilling its responsibility to oversee and participate in the creation and
administration of executive compensation programs and practices. Responsibilities of the Compensation Committee include, among other things:



| |  |  | Review and determination of the annual salary of the Companys chief executive officer and other executive officers;
| | - |  | --------------------------------------------------------------------------------------------------------------------



| |  |  | Review and approval of the Companys management incentive compensation policies and programs; and
| | - |  | -------------------------------------------------------------------------------------------------



| |  |  | Review and approval of equity compensation programs for the Companys employees, directors and consultants, including grants of options, restricted stock and other awards thereunder.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The Compensation Committee acts pursuant to the Compensation Committee Charter. This Charter can be found on our corporate website,www.juniperpharma.com.

The current members of our Compensation Committee are Dr. Frank M. Armstrong (Chair), Dr. Cristina
Csimma and Ms. Ann Merrifield. Each of these individuals has been determined by the Board to be independent within the meaning of the applicable Nasdaq Marketplace Rules.

The Compensation Committee meets at regularly scheduled times during the year and on an ad hoc basis as business needs necessitate. In
2015, the Compensation Committee held 9 meetings. The Compensation Committee has the authority under its charter to retain independent consultants and legal counsel to provide guidance on matters related to executive compensation and other related
matters; provided, however, that the Compensation Committee must take into account certain independence factors outlined in the Nasdaq Marketplace Rules in making their selections.

Risk Assessment

The Compensation
Committee regularly undertakes a qualitative assessment of the extent to which the Companys compensation program encourages or may aggravate or mitigate unnecessary or excessive risk-taking behavior by executive officers. The Compensation
Committee has concluded that the Companys executive compensation program maintains an appropriate balance between risks and rewards.

Executive Compensation Philosophy and Objectives

Our compensation program for the individuals named in the Summary Compensation Table (the named executive officers) is designed
and implemented based on our pay-for-performance compensation philosophy. Our named executive officers for 2015 were Frank C. Condella Jr., President and Chief Executive Officer (CEO); George O. Elston, Chief Financial Officer;
Dr. Nikin Patel, Chief Operating Officer; and Dr. Bridget Martell, Chief Medical Officer.

We strive to adhere to our
pay-for-performance philosophy by differentiating the pay and rewards of our executive officers based on their demonstrated performance and potential to contribute to the long-term success of the Company. Competing for talent in the rapidly changing
and increasingly competitive pharmaceutical industry is both challenging and critical to our success. We need and want the best people to be excited and motivated to work at Juniper and to understand that their rewards are driven by the
Companys performance and by their individual contributions to the Companys performance. The quality of the Companys talent is a key component of long-term stockholder value.

The Company has entered into employment agreements with each of Messrs. Condella and Elston and Drs. Patel and Martell because we
believe that they are a fair and effective way to maintain focus on our business in the face of market and other volatility in our industry. These employment agreements contain certain confidentiality and non-competition provisions.



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We have established a total rewards framework that supports our compensation philosophy through
the following objectives:



| |  |  | to afford our executives a competitive total rewards opportunity comparable to organizations with which we compete for executive talent;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------



| |  |  | to allow us to attract and retain executives who can perform and succeed in our fast-paced and challenging environment; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------



| |  |  | to deliver compensation in a cost-efficient manner that aligns employees rewards with stockholders long-term interests.
| | - |  | -------------------------------------------------------------------------------------------------------------------------

Compensation Program Elements and Pay Level Determination

The Compensation Committee undertakes discussions and assessments of compensation-related programs and the performance of management
throughout the year. Early in the Companys fiscal year, the Compensation Committee reviews and recommends base salaries, annual cash incentive bonuses, and equity incentives for all executive officers based on the prior years
performance, which are then approved by all non-employee directors.

As part of the review process, the CEO provides to the Compensation
Committee an individual assessment of the major accomplishments of each executive officer over the prior year and recommends compensation for each such executive officer. The Compensation Committee evaluates the performance of our CEO and recommends
to the Board for its approval all compensation elements and amounts to be awarded to our CEO. Our CEO, who is a member of the Board of Directors, does not participate in Board decisions relating to his own compensation. The key metrics we use to
measure the performance of our executive officers can be grouped into the following categories:



| |  |  | FinancialWe evaluate measures of our financial performance such as revenue, expense management and cash flow metrics.
| | - |  | ----------------------------------------------------------------------------------------------------------------------



| |  |  | OperationalWe evaluate operational measures to determine that the Company is operating effectively and efficiently.
| | - |  | --------------------------------------------------------------------------------------------------------------------



| |  |  | StrategicWe evaluate strategic measures to determine our executive officers effectiveness in developing and implementing a long-term plan for the Company that is expected to increase the market
capitalization of the Company over time.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The Compensation Committee considers the recommendations of the CEO and other
information (including each executives significant accomplishments, external competitiveness, Company performance, progress towards strategic objectives, and internal equity among executive officers) and applies its knowledge and discretion to
determine the compensation for each executive officer.

Public Company Peer Group

To understand external competitiveness, the Compensation Committee compares each element of total compensation against a peer group of
publicly traded pharmaceutical and biotechnology companies. Company management first recommends a list of companies as the peer group, including specialty pharmaceuticals/drug delivery companies and companies providing products and services to the
life sciences industry. Management also considers the types of products sold or developed by such companies, as well as their market capitalization, revenues, and number of employees. The Compensation Committee then reviews the list of companies
proposed by management and selects the peer group as it deems appropriate and reasonable.



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The following companies comprised our public company peer group for 2015:



|                                                                         |  |  |      | 
|------------------------------------------------------------------------ |  |  | ---- | 
|Alexza Pharmaceuticals                                                   |  |  | ALXA | 
|ANI Pharmaceuticals, Inc.                                                |  |  | ANIP | 
|Antares Pharma, Inc.                                                     |  |  | ATRS | 
|BioDelivery Sciences International, Inc.                                 |  |  | BDSI | 
|Caladrius BioSciences (formerly NeoStem, Inc.)                           |  |  | CLBS | 
|Codexis, Inc.                                                            |  |  | CDXS | 
|Elite Pharmaceuticals, Inc.                                              |  |  | ELTP | 
|Epirus Biopharmaceuticals, Inc. (formerly Zalicus, Inc.)                 |  |  | EPRS | 
|NovaBay Pharmaceuticals, Inc.                                            |  |  | NBY  | 
|Ocera Therapeutics, Inc.                                                 |  |  | OCRX | 
|Pain Therapeutics, Inc.                                                  |  |  | PTIE | 
|Paratek Pharmaceuticals, Inc. (formerly Transcept Pharmaceuticals, Inc.) |  |  | PRTK | 
|Pozen, Inc.                                                              |  |  | POZN | 

The Role of Stockholder Say-on-Pay Votes

As required by Section 14A of the Exchange Act, the Company provides its stockholders with the opportunity to cast an annual advisory
vote on executive compensation (a say-on-pay proposal). At the Companys annual meeting of stockholders held in July 2015, a substantial majority of the votes cast on the say-on-pay proposal at that meeting were voted in favor of
the proposal. The Compensation Committee believes that this result affirms the stockholders support for the Companys approach to executive compensation, and, therefore, the Company did not make any changes to its approach to executive
compensation in 2016. The Compensation Committee will continue to consider the outcome of the Companys say-on-pay votes when making future decisions regarding the compensation of its executive officers.

Components of our Executive Compensation Program

Total compensation for our named executive officers generally consists of a mix of cash and equity awards. Base salaries and discretionary
annual incentive bonuses are paid in cash. Long-term incentives are provided in the form of stock option awards. Named executive officers also receive standard employee benefits.

Each component of compensation and selected benefits is summarized in the table below.



|                       |  |                                                                                                                                                                        
|---------------------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Component              |  | Purpose/Description                                                                                                                                                    
|Base salary            |  | Competitive fixed income for performance of day-to-day responsibilities. Paid semi-monthly for U.S. employees; monthly for UK employees.                               
|                       | 
|Annual incentive bonus |  | Rewards achievement of annual goals that support short-term (annual) business objectives. Paid in cash after the relevant fiscal year.                                 
|                       | 
|Equity compensation    |  | Fosters a culture of ownership, aligns compensation with stockholder interests, and promotes long-term retention with the Company. Consists primarily of stock options.
|                       | 
|Benefits               |  | Standard employee benefits, such as health, dental, vision, short- and long-term disability, and life insurance.                                                       



10



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##### Table of Contents

|                    |  |                                                                                                                                                                                
|------------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Component           |  | Purpose/Description                                                                                                                                                            
|Retirement Benefits |  | Standard employee 401(k) Plan. The Companys safe harbor non-elective contribution to the savings plan is in the amount equal to 3% of base salary up to the statutory maximum.
|Perquisites         |  | None.                                                                                                                                                                          

While the general mix of each compensation component is considered in the design of our total compensation
program, the Compensation Committee does not target a specific mix of pay either in its program design or in its compensation determinations. By design, our executive officers have more variability in their compensation than non-executives, to more
closely tie their compensation to the Companys overall performance. The Compensation Committee considers each element of total compensation offered by the Company against each element of total compensation provided by our peer group companies.

Base Salary

We pay our executive
officers base salaries to provide a baseline level of compensation that is both competitive with the external market and our peer group, and commensurate with each executive officers past performance, experience, responsibilities, and skills.
The base salary levels of our executive officers may be increased from time to time to recognize external competitive compensation levels, internal pay equity, and individual contributions and performance.

Generally, the Compensation Committee compares our executive officers base salaries with base salaries of individuals in comparable
positions at the peer group companies. In connection with determining the base salary levels for the Companys executive officers, the Compensation Committee compares their total cash compensation (i.e. base salary plus target annual bonus) to
total cash compensation of individuals in comparable positions at the peer group companies.

The 2015 base salaries of each of our named
executive officers were as follows: Mr. Condella$340,000; Mr. Elston$300,000; Dr. Patel£183,266; and Dr. Martell$280,000.

Annual Cash Incentive Bonus

We maintain
an annual cash incentive program (the Incentive Plan), the purpose of which is to motivate and reward the attainment of annual Company and individual performance goals. For our named executive officers, annual incentive opportunities,
which are expressed as a percentage of base salary, can range from 0% to 150% of targeted levels, depending on the degree of attainment of pre-established Company goals and individual goals for the particular year. In order for any named executive
officer to be eligible to receive an annual incentive bonus, the Company must achieve 50% of the pre-established target corporate goals (as described below).

Actual payouts under the Incentive Plan are recommended by the Compensation Committee to the Board based on achievement of corporate goals,
overall individual performance, and the broad discretion of the Compensation Committee and the Board. Our corporate goals are jointly established at the beginning of each year by management and the Compensation Committee and are approved by the
Compensation Committee and the Board. Once the corporate goals are finalized and approved by the Board, they are clearly communicated to executives. Executives are aware of the overall bonus program, targets, annual goals, and performance measures
that impact the annual bonus payout.

The extent to which corporate goals are achieved is assessed by the Compensation Committee with
input from the CEO and other members of management. The Compensation Committee considers the following in assessing cash bonuses:



| |  |  | The extent to which corporate goals are achieved or exceeded; and
| | - |  | -----------------------------------------------------------------



| |  |  | The overall success of the Company throughout the year as determined by factors such as progress in key programs, execution of the strategic plan, and share price.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------



11



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##### Table of Contents

2015 Annual Cash Incentive Bonuses

Bonus targets for 2015 for Messrs. Condella and Elston and Drs. Patel and Martell were 70%, 40%, 70% and 40% of their base salary,
respectively, pursuant to their individual employment agreements.

The following table summarizes the Companys goals for 2015 and
the Compensation Committees determination with respect to the achievement level of each such goal.



|                                                                     |  |        |     |   |         |                   |             |  |    |  
|-------------------------------------------------------------------- |  | ------ | --- | - | ------- | ----------------- | ----------- |  | -- | -
|Company Goal                                                         |  | Weight |     |   | Results |                   | Achievement | 
|Financial Goals                                                      |  |        |     |   |         |                   |             |  |    |  
|Achieve fiscal year EBITDA target of $1.67 million (1)               |  |        | 10  | % |         | Goal Achieved     |             |  | 10 | %
|Gain coverage by at least one additional research analyst            |  |        | 5   | % |         | Goal Achieved     |             |  | 5  | %
|Institutional investors targeted ownership of outstanding shares    |  |        | 5   | % |         | Goal Achieved     |             |  | 5  | %
|Operational Goals                                                    |  |        |     |   |         |                   |             |  |    |  
|Maintain or surpass target CRINONE service supply chain levels       |  |        | 10  | % |         | Goal Overachieved |             |  | 15 | %
|Achieve fiscal year service revenue target of at least $10.4 million |  |        | 20  | % |         | Goal Overachieved |             |  | 25 | %
|Strategic Goals                                                      |  |        |     |   |         |                   |             |  |    |  
|Complete targeted enrollment for POC study for COL-1077              |  |        | 20  | % |         | Goal Not Achieved |             |  | 0  | %
|Request pre-IND meeting with the FDA for second product by year end. |  |        | 20  | % |         | Goal Achieved     |             |  | 20 | %
|Implement SAB and have initial meeting by end of second quarter 2015 |  |        | 10  | % |         | Goal Achieved     |             |  | 10 | %
|                                                                     |  |        |     |   |         |                   |             |  |    |  
|Total                                                                |  |        | 100 | % |         |                   |             |  | 90 | %



|(1) | EBITDA was calculated as follows: Net (loss) income plus depreciation and amortization, stock-based compensation expense, and interest expense, net, less (benefit from) provision for income taxes as reported in the
Companys earnings release. For purposes of calculating achievement of this goal for 2015, EBITDA was adjusted for certain exceptional expenses that were approved by the Compensation Committee.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The Compensation Committee recognized the Companys achievement of the 2015 goals at 90% in the aggregate, which was more than the
required 50% minimum achievement level for corporate goals.

Individual performance goals were established for each of the named
executive officers in the first quarter of 2015. The Compensation Committee recognized achievement of the individual 2015 goals as follows: Messrs. Condella and Elston100%; and Drs. Patel and Martell115%.

Based on this determination, the 2015 annual cash incentive bonuses payments made to the named executive officers were as follows:



|                       |  |                                       |  |                                   |         |  |                                 |   |         |    
|---------------------- |  | ------------------------------------- |  | --------------------------------- | ------- |  | ------------------------------- | - | ------- | ---
|Name                   |  | Position                              |  | 2015 Target AnnualIncentive Bonus |         |  | 2015 Annual IncentiveBonus Paid |  
|                       |  |                                       | 
|Frank C. Condella, Jr. |  | President and Chief Executive Officer |  | $                                 | 238,000 |  |                                 | $ | 218,960 |    
|George O. Elston       |  | Chief Financial Officer               |  | $                                 | 120,000 |  |                                 | $ | 110,400 |    
|Dr. Nikin Patel        |  | Chief Operating Officer               |  | $                                 | 178,019 |  |                                 | $ | 169,085 | (1)
|Dr. Bridget Martell    |  | Chief Medical Officer                 |  | $                                 | 112,000 |  |                                 | $ | 106,400 |    



|(1) | The amount shown for Dr. Patel represents the amount that was paid in British pound (£121,848) and converted to U.S. dollars for purposes of this table, using an exchange rate as of February 29, 2016 of 1.38767
U.S. dollars for each British pound.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



12



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Equity Compensation

An equity compensation program is provided to all executives and certain key employees to foster a culture of ownership, align compensation
with stockholder interests, and promote long-term retention with the organization. Each year the Compensation Committee determines the types of awards to be used for equity compensation. In doing so, the Compensation Committee considers the ability
of each type of award to achieve key compensation objectives (such as employee retention, motivation, and attraction), the needs of the business, competitive market practices, dilution, and expense constraints, as well as tax and accounting
implications.

Stock options awarded under the Juniper Pharmaceuticals, Inc. 2015 Long-Term Performance Plan (the 2015 Plan)
must be equal to or greater than the fair market value (i.e., the closing price) of the Companys Common Stock on the Nasdaq Global Market on the date of grant. Stock option grants are normally approved at Board and Compensation Committee
meetings that are generally scheduled a year in advance. Scheduling decisions are made without regard to anticipated financial reporting dates or other major announcements by the Company.

Newly hired employees, including executive officers, may be granted options effective on the first day of employment, with such options
having an exercise price set at the fair market value (i.e., the closing price) of our Common Stock on the Nasdaq Global Market on the employment start date. Our employees start dates are scheduled without regard to anticipated financial
reporting dates or other major announcements by the Company.

We have historically made an annual grant of employee stock options at the
time of the annual review of each executives performance, usually in February or early March of each year. Stock option grants typically vest over four years to provide an incentive for employees to remain with the Company and to increase
stockholder value.

In determining the equity awards for 2015, the Compensation Committee concluded as follows: (1) the equity
awards should be comparable to those provided by our peer group of companies; (2) the aggregate grants should be limited, so as not to exceed a predetermined dilution effect; and (3) the grants to executive officers should be within a
range that is appropriate from a Company-wide internal fairness perspective.

Based on these determinations, on February 11, 2015, Mr.
Condella was granted a stock option to purchase 40,000 shares, and Dr. Patel was granted a stock option to purchase 32, 000 shares. Each of the stock options granted to Mr. Condella and Dr. Patel vests in increments of 6.25% every three months
beginning on the date that is three months after the grant date. Dr. Martell was granted a stock option to purchase 60,000 shares on January 6, 2015, in connection with her joining the Company. This option vests at a rate of 25% per year on each
anniversary of the grant date. Mr. Elston received a new hire stock option grant in October 2014 and did not, therefore, receive a stock option grant in 2015.

Benefits and Perquisites

All named
executive officers are offered the standard benefits that are offered to other full-time employees of the Company. For U.S. employees, these standard benefits include health, dental, vision, and life insurance, and both short- and long-term
disability. UK employees receive health insurance and life insurance.

In addition, the Company offers a 401(k) plan to its U.S.
employees and contributes a safe harbor non-elective contribution in an amount equal to 3% of the employees base salary up to the statutory maximum. UK employees are entitled to a matching 3% retirement plan contribution (of gross annual
salary) from the Company.

The Company does not provide perquisites for our executive officers.



13



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##### Table of Contents

Compensation Policy Implementation in 2016

As noted elsewhere in this Compensation Discussion and Analysis section, the Compensation Committee believes that it is important when making
compensation decisions to be informed as to the current practices of comparable, publicly-held companies. In the late summer of 2015, the Compensation Committee engaged Radford Associates (Radford) as compensation consultants to provide
executive and non-employee director compensation consulting services.

Before retaining Radford, the Compensation Committee considered the
independence of Radford in accordance with applicable NASDAQ Marketplace Rules, and determined that Radford is independent under applicable NASDAQ rules. Radford did not provide any services to the Company in 2015, other than to the Compensation
Committee.

At the Compensation Committees request, Radford undertook a review of the Companys peer group and provided
recommendations to the Compensation Committee based on their findings. Based, in part, on Radfords recommendations, the Compensation Committee revised the Companys peer group, based on the following key factors: market capitalization,
industry focus (defined as commercial biotechnology and pharmaceutical companies), stage of development (defined as Phase 2 or Phase 3 products), revenue and number of employees.

The following 20 companies were selected for our 2016 peer group:



|                                                |  |                                       
|----------------------------------------------- |  | --------------------------------------
|Alimera Sciences, Inc. (ALIM)                   |  | Endocyte, Inc. (ECYT)                 
|                                                | 
|Antares Pharma, Inc. (ATRS)                     |  | EPIRUS Biopharmaceuticals, Inc. (EPRS)
|                                                | 
|Argos Therapeutics (ARGS)                       |  | Ocera Therapeutics, Inc. (OCRX)       
|                                                | 
|Athersys, Inc. (ATHX)                           |  | OncoGenex Pharmaceuticals, Inc. (OGXI)
|                                                | 
|BioDelivery Sciences International, Inc. (BDSI) |  | Pain Therapeutics Inc. (PTIE)         
|                                                | 
|Caladrius Biosciences, Inc. (CLBS)              |  | Paratek Pharmaceuticals, Inc. (PRTK)  
|                                                | 
|Codexis, Inc. (CDXS)                            |  | Pozen Inc. (POZN)                     
|                                                | 
|CTI BioPharma Corp. (CTIC)                      |  | Rigel Pharmaceuticals, Inc. (RIGL)    
|                                                | 
|Cytokinetics, Incorporated (CYTK)               |  | XOMA Corporation (XOMA)               
|                                                | 
|Elite Pharmaceuticals, Inc. (ELTP)              |  | Zogenix, Inc. (ZGNX)                  

Following its review of the executive compensation paid by the Companys peer group companies and other
survey information provided by Radford with respect to compensation paid by biopharmaceutical companies generally, the Compensation Committee determined that an increase in the base salaries of our named executive officers was advisable,
particularly with respect to Mr. Condellas base salary, which has not been adjusted since 2013 and was found to be well below the 25th percentile of base salary paid to the chief executive
officers at our previous and new peer group companies. The Compensation Committee recommended, and the Board approved, the following adjustments to base salary for 2016: Mr. Condella$410,000; Mr. Elston$320,000; Dr.
Patel£205,218; and Dr. Martell$320,000.

Based on its review of overall compensation paid to the chief operating
officers of the peer group companies, with input from Radford, and after considering the adjustment made to Dr. Patels base salary and internal equity considerations with respect to the Companys other executive officers, the Compensation
Committee also recommended, and the Board approved, an adjustment to the target bonus opportunity payable to Dr. Patel for 2016 from 70% of base salary to 55% of base salary.



14



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##### Table of Contents

The Compensation Committee also determined, based on its review of overall compensation, and
equity compensation specifically, and with input from Radford, that an increase in the annual equity grants to our executive officers, which were found to be well below the 25th percentile of the
equity grants made to executive officers at our previous and new peer group companies, was advisable. The Compensation Committee recommended, and the Board approved, the following annual equity grants for 2016: Mr. Condella  110,000
shares, Mr. Elston  50,000 shares, Dr. Patel  50,000 shares, and Dr. Martell  50,000 shares.

Termination or Change in Control

We have entered into employment agreements with each of Messrs. Condella and Elston and Drs. Patel and Martell. The employment agreements
provide for payments to be made to the executives if their employment is terminated under certain circumstances. We believe agreements of this type can be important components of our effort to recruit and retain senior executives, particularly for
companies at our stage of development and in our relatively high-risk industry.

In addition, our 2015 Plan provides for the acceleration
and vesting of equity awards granted under the plan in the event of a Change of Control.

A further discussion of the potential payments
to be made to our executive officers upon the termination of their employment and/or a Change in Control is set forth below under the heading Potential Payments upon Termination or Change in Control.

Tax Considerations

Section 162(m)
of the Internal Revenue Code limits to $1 million the deductibility for federal income tax purposes of annual compensation paid by a publicly held company to its chief executive officer and its other named executive officers (other than its chief
financial officer), unless certain conditions are met. To the extent feasible, we structure executive compensation to preserve deductibility for federal income tax purposes. In this regard, our equity incentive plans are designed to preserve, to the
extent otherwise available, the deductibility of income realized pursuant to these plans. Nevertheless, we retain the flexibility to authorize compensation that may not be deductible if we believe it is in the best interest of the Company.



15



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##### Table of Contents

Executive and Director Compensation

Summary Compensation Table (for Fiscal Years 2015, 2014 and 2013)



|                                                            |  |      |              |  |           |  |                       |                    |  |  |                                            |  |  |                             |                   |  |          |  |                 |  |  |  |                       | 
|----------------------------------------------------------- |  | ---- | ------------ |  | --------- |  | --------------------- | ------------------ |  |  | ------------------------------------------ |  |  | --------------------------- | ----------------- |  | -------- |  | --------------- |  |  |  | --------------------- | 
|Name and principal position                                 |  | Year |              |  | Salary($) |  |                       | OptionAwards(1)($) |  |  | Non-EquityIncentive PlanCompensation(2)($) |  |  | All OtherCompensation(3)($) |                   |  | Total($) | 
|Frank C. Condella, Jr.President and Chief Executive Officer |  |      | 201520142013 |  |           |  | 340,000340,000340,000 |                    |  |  | 133,040180,258132,375                      |  |  |                             | 218,960  214,200 |  |          |  | 9,3507,6507,650 |  |  |  | 701,350527,908694,225 | 
|                                                            |  |      |              |  |           | 
|George O. ElstonChief Financial Officer                     |  |      | 20152014     |  |           |  | 300,00075,000         |                    |  |  |   275,416                                 |  |  |                             | 110,400          |  |          |  | 8,25051,500     |  |  |  | 418,650401,916        | 
|                                                            |  |      |              |  |           | 
|Dr. Nikin Patel(4)Chief Operating Officer                   |  |      | 201520142013 |  |           |  | 271,270284,64986,017  |                    |  |  | 106,432144,206                            |  |  |                             | 169,085  87,743  |  |          |  | 8,1388,5397,987 |  |  |  | 554,925437,394181,747 | 
|                                                            |  |      |              |  |           | 
|Dr. Bridget MartellChief Medical Officer                    |  |      | 2015         |  |           |  | 284,649               |                    |  |  | 205,353                                    |  |  |                             | 106,400           |  |          |  | 7,000           |  |  |  | 603,402               | 



|(1) | This column represents the grant date fair values of the stock options awarded in 2015, 2014 and 2013, computed in accordance with Financial Accounting Standards Board Accounting Standards Codification Topic 718
(ASC Topic 718). See Note 2 to the consolidated financial statements included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2015 (2015 Annual
Report), as originally filed on March 10, 2016, regarding the assumptions underlying the valuation of our equity awards.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | This column represents incentive compensation earned under the Companys Incentive Plan. See Compensation Discussion and Analysis2015 Annual Cash Incentive Bonuses for information concerning the
determination of these awards.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | The amounts reported in this column include the Companys safe harbor non-elective contribution to the named executive officers 401(k) savings account in the amount equal to 3% of base salary.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(4) | For Dr. Patel, the amounts shown (other than for non-equity incentive plan compensation) represent amounts that were paid in British pound and converted to U.S. dollars using an exchange rate as of
December 31, 2015, 2014 and 2013 of 1.4802, 1.5532 and 1.649077 U.S. dollars, respectively, for each British pound. The amounts shown for non-equity incentive plan compensation represent the amounts that were paid in British pound and converted
to U.S. dollar using an exchange rate as of the date they were paid, which was 1.38767 for his 2015 award which was paid on February 29, 2016, and 1.67109 for his 2013 award which was paid on February 28, 2014. For 2013, these amounts are a
representation of compensation paid or earned from September 12, 2013 to December 31, 2013.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Total Realized Compensation

To supplement the SEC-required disclosure in the Summary Compensation Tableset forth above, we have included the
additional table below, which shows Total Realized Compensation representing the total compensation realized by each named executive officer in each of the years shown. Total compensation as calculated under SEC rules and, as shown in
the Summary Compensation Table, includes several items that are driven by accounting assumptions, which are not necessarily reflective of compensation actually realized by the named executives in a particular year. The amounts reported in the
Total Realized Compensation column differ substantially from the amounts reported in the Total column required under SEC rules and are not a substitute for those Total amounts. Total Realized Compensation represents: (1) Total compensation, as
determined under



16



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##### Table of Contents

applicable SEC rules, minus (2) the aggregate grant-date fair value of restricted stock awards and stock option awards (as reflected in the Stock Awards columns and Option Awards column),
plus (3) the value realized in the applicable year from the vesting of restricted stock and exercises of stock options.



|                                                            |  |      |              |  |                            |     |                       | 
|----------------------------------------------------------- |  | ---- | ------------ |  | -------------------------- | --- | --------------------- | 
|Name and Principal Position                                 |  | Year |              |  | Total RealizedCompensation |    
|Frank C. Condella, Jr.President and Chief Executive Officer |  |      | 201520142013 |  |                            | $$$ | 568,310347,650561,850 | 
|                                                            |  |     
|George O. ElstonChief Financial Officer                     |  |      | 20152014     |  |                            | $$  | 418,650126,500        | 
|                                                            |  |     
|Dr. Nikin Patel(1)Chief Operating Officer                   |  |      | 201520142013 |  |                            | $$$ | 448,493293,188181,747 | 
|                                                            |  |     
|Dr. Bridget MartellChief Medical Officer                    |  |      | 2015         |  |                            | $   | 398,049               | 



|(1) | The amount shown in the table above for Dr. Patel have been converted from British pounds to U.S. dollars using an exchange rate as of December 31, 2015, 2014 and 2013 of 1.4802, 1.5532 and 1.649077 U.S.
dollars, respectively, for each British pound. The amounts shown for 2013 are a representation of compensation paid or earned from September 12, 2013 to December 31, 2013.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2015 Grants of Plan-Based Awards Table

The following table provides information about annual incentive bonus and equity awards granted to the named executive officers in 2015.



|                                                            |  |            |              |  |                                                                     |  |      |                                                                   |  |  |                                                 |  |  |                                                 |          |  |  |  |           |  |  |  |         |  |  |  |            | 
|----------------------------------------------------------- |  | ---------- | ------------ |  | ------------------------------------------------------------------- |  | ---- | ----------------------------------------------------------------- |  |  | ----------------------------------------------- |  |  | ----------------------------------------------- | -------- |  |  |  | --------- |  |  |  | ------- |  |  |  | ---------- | 
|                                                            |  |            |              |  | Estimated Possible Payouts UnderNon-Equity Incentive Plan Awards(1) |  |      | All
OtherOptionAwards:Number ofSecuritiesUnderlyingOptions (#)(2) |  |  | Exerciseor BasePriceof OptionAwards($/share)(3) |  |  | Grant DateFair Value ofStock andOptionAwards(4) |         
|Name                                                        |  | Grant Date |              |  | Threshold($)                                                        |  |      | Target($)                                                         |  |  | Maximum($)                                      |  |  |                                                 |          |  |  |  |           |  | 
|Frank C. Condella, Jr.President and Chief Executive Officer |  |            |   2/11/2015 |  |                                                                     |  |    |                                                                   |  |  | 238,000                                        |  |  |                                                 | 357,000 |  |  |  |   40,000 |  |  |  |   5.56 |  |  |  |   133,040 | 
|                                                            |  |            |              |  |                                                                     |  |     
|George O. ElstonChief Financial Officer                     |  |            |             |  |                                                                     |  |     |                                                                   |  |  | 120,000                                         |  |  |                                                 | 180,000  |  |  |  |          |  |  |  |        |  |  |  |           | 
|                                                            |  |            |              |  |                                                                     |  |     
|Dr. Nikin PatelChief Operating Officer(5)                   |  |            |   2/11/2015 |  |                                                                     |  |    |                                                                   |  |  | 189,889                                        |  |  |                                                 | 284,834 |  |  |  |   32,000 |  |  |  |   5.56 |  |  |  |   106,432 | 
|                                                            |  |            |              |  |                                                                     |  |     
|Dr. Bridget MartellChief Medical Officer                    |  |            |   1/6/2015  |  |                                                                     |  |    |                                                                   |  |  | 112,000                                        |  |  |                                                 | 168,000 |  |  |  |   60,000 |  |  |  |   5.63 |  |  |  |   205,353 | 



|(1) | These columns show the range of possible payouts for 2015 annual incentive compensation granted under the Incentive Plan. For a description of the 2015 annual incentive program, see Compensation Discussion and
Analysis2015 Annual Cash Incentive Bonuses. The actual amounts paid to our named executive officers under the 2015 annual incentive program were as follows  Mr. Condella, $218,960; Mr. Elston, $110,400; Dr. Patel, $169,085; and Dr.
Martell, $106,400.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



17



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|(2) | Represents the number of shares underlying stock option awards that were granted to the named executive officers in 2015 under the 2015 Plan. Each of these awards has a seven year term. The stock options granted to Mr.
Condella and Dr. Patel vest in increments of 6.25% every three months beginning on the date that is three months after the grant date. Dr. Martells stock option vests at a rate of 25% per year on each anniversary of the grant date.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | The exercise price is the closing price on the Nasdaq Global Market on the date of grant.
|--- | -----------------------------------------------------------------------------------------

|(4) | These amounts represent the grant date fair value of the stock option awards granted to the named executive officers in 2015, computed in accordance with the ASC Topic 718. See Note 2 to the consolidated financial
statements included in our 2015 Annual Report as originally filed on March 10, 2016, regarding the assumptions underlying the valuation of our equity awards.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | The amount shown in the table above for Dr. Patels non-equity incentive plan award has been converted from British pounds to U.S. dollars using an exchange rate as of December 31, 2015, 2014 and 2013 of
1.4802, 1.5532 and 1.649077 U.S. dollars, respectively, for each British pound. For 2013, these amounts are a representation of compensation paid or earned from September 12, 2013 to December 31, 2013.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



18



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##### Table of Contents

Outstanding Equity Awards at 2015 Fiscal Year-End

The following table provides information on the holdings of stock options and stock awards by the named executive officers as of
December 31, 2015. The table includes unexercised and unvested option awards. Each equity grant is shown separately for each named executive officer. The vesting schedule for each grant is shown following this table, based on the option or
stock award grant date.



|                                                            |  |                  |                                                                |  |                                                               |  |                                          |                                                                    |  |  |                                 |  |  |                      |                               |  |  |  |                                                                | 
|----------------------------------------------------------- |  | ---------------- | -------------------------------------------------------------- |  | ------------------------------------------------------------- |  | ---------------------------------------- | ------------------------------------------------------------------ |  |  | ------------------------------- |  |  | -------------------- | ----------------------------- |  |  |  | -------------------------------------------------------------- | 
|                                                            |  | Option Awards    |                                                               
|Name                                                        |  | Option GrantDate |                                                                |  | Number ofSecuritiesUnderlyingUnexercisedOptions(#)Exercisable |  |                                          | Number ofSecuritiesUnderlyingUnexercisedOptions(#)Unexercisable(1) |  |  | OptionExercisePrice($)          |  |  | OptionExpirationDate |                              
|Frank C. Condella, Jr.President and Chief Executive Officer |  |                  | 12/11/20099/15/20102/7/20112/29/20123/1/20133/10/20142/11/2015 |  |                                                               |  | 12,50043,74839,37429,5309,37510,0007,500 |                                                                    |  |  |   
  9,84418,75030,00032,500 |  |  |                      | 6.968.5620.725.284.967.055.56 |  |  |  | 12/11/20169/15/20172/7/20182/29/20193/1/20203/10/20212/11/2022 | 
|                                                            |  |                  |                                                                |  |                                                              
|George O. ElstonChief Financial Officer                     |  |                  | 10/1/2014                                                      |  |                                                               |  | 18,750                                   |                                                                    |  |  | 56,250                          |  |  |                      | 5.97                          |  |  |  | 10/1/2021                                                      | 
|                                                            |  |                  |                                                                |  |                                                              
|Dr. Nikin PatelChief Operating Officer                      |  |                  | 3/10/20142/11/2015                                             |  |                                                               |  | 8,0006,000                               |                                                                    |  |  | 24,00026,000                    |  |  |                      | 7.055.56                      |  |  |  | 3/10/20212/11/2022                                             | 
|                                                            |  |                  |                                                                |  |                                                              
|Dr. Bridget MartellChief Medical Officer                    |  |                  | 1/6/2015                                                       |  |                                                               |  |                                         |                                                                    |  |  | 60,000                          |  |  |                      | 5.63                          |  |  |  | 1/6/2022                                                       | 



|(1) | Option Awards Vesting Schedule:
|--- | -------------------------------



|           |  |                                                                                                                                                                                   
|---------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Grant Date |  | Vesting Schedule                                                                                                                                                                  
|           | 
|2/29/2012  |  | The remaining shares vested as follows: 9,844 shares on 2/29/2016.                                                                                                                
|           | 
|3/1/2013   |  | The remaining shares vested/vest as follows: 9,375 shares on 3/1/2016 and 9,375 shares on 3/1/2017.                                                                               
|           | 
|3/10/2014  |  | The remaining shares vested/vest as follows:                                                                                                                                      
|           | 
|           |  |      Mr. Condella10,000 shares on 3/10/2016, 10,000 shares on 3/10/2017, and 10,000 shares on 3/10/2018.                                                                        
|           | 
|           |  |      Dr. Patel8,000 shares on 3/10/2016, 8,000 shares on 3/10/2017 and 8,000 shares on 3/10/2018.                                                                               
|           | 
|10/1/2014  |  | The remaining shares vest as follows: 18,750 shares on 10/1/2016, 18,750 shares on 10/1/2017, and 18,750 shares on 10/1/2018.                                                     
|           | 
|1/6/2015   |  | The remaining shares vested/vest as follows: 15,000 shares on 1/6/2016, 15,000 shares on 1/6/2017, 15,000 shares on 1/6/2018 and 15,000 shares on 1/6/2019.                       
|           | 
|2/11/2015  |  | The remaining shares vested/vest in increments of 6.25% every three months as follows: Mr. Condella 2,500 shares every three months and Dr. Patel 2,000 shares every three months.



19



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##### Table of Contents

Option Exercises and Stock Vested in 2015



|                                      |  |                                          |       |  |                               |  |        | 
|------------------------------------- |  | ---------------------------------------- | ----- |  | ----------------------------- |  | ------ | 
|                                      |  | Option Awards                            |      
|Name                                  |  | Number of Shares Acquiredon Exercise (#) |       |  | Value Realizedon Exercise ($) | 
|Frank C. Condella, Jr.                |  |                                          | 9,375 |  |                               |  | 46,406 | 
|President and Chief Executive Officer |  |                                          |       |  |                               |  |        | 
|                                      |  |                                         
|George O. Elston                      |  |                                          |      |  |                               |  |       | 
|Chief Financial Officer               |  |                                          |       |  |                               |  |        | 
|                                      |  |                                         
|Dr. Nikin Patel                       |  |                                          |      |  |                               |  |       | 
|Chief Operating Officer               |  |                                          |       |  |                               |  |        | 
|                                      |  |                                         
|Dr. Bridget Martell                   |  |                                          |      |  |                               |  |       | 
|Chief Medical Officer                 |  |                                          |       |  |                               |  |        | 

Payments upon Termination or Change in Control

We have entered into employment agreements with each of Messrs. Condella and Elston and Drs. Patel and Martell, which require us to
provide to them cash compensation, benefits, and/or the acceleration of the vesting of equity awards in the event of their termination of employment, as described below. The severance payments described below are subject to the executives
execution of a general release of the Company, as described in the various agreements.

In addition, our 2015 Plan provides that in the
event of a Change of Control, any outstanding and unexercised stock option award will become immediately and fully exercisable, and will remain exercisable until it would otherwise expire or be forfeited, and all other outstanding awards
granted under the 2015 Plan will become immediately and fully vested.

The 2015 Plan defines Change of Control as:

(i) The acquisition by any Person (as such term is defined in Section 3(a) (9) of the Exchange Act and used in Sections 13(d) and
14(d) thereof, including a group as defined in Section 13(d) thereof) of Beneficial Ownership (within the meaning of Rule 13d-3 under the Exchange Act) of more than 50% of either (A) the then-outstanding Shares
(Outstanding Company Common Stock) or (B) the combined voting power of the then-outstanding voting securities of the Company entitled to vote generally in the election of directors (the Outstanding Company Voting Securities);
provided, however, that, the following acquisitions will not constitute a Change in Control: (1) any acquisition by the Company, (2) any acquisition by any employee benefit plan (or related trust) sponsored or maintained by the Company, (3) any
acquisition by any entity controlled by the Company, or (4) any acquisition by any entity pursuant to a transaction that complies with Section 13(f)(ii)(A), (B) or (C);

(ii) Consummation of a reorganization, merger, statutory share exchange or consolidation or similar corporate transaction involving the
Company and/or any entity controlled by the Company, or a sale or other disposition of all or substantially all of the assets of the Company, or the acquisition of assets or stock of another entity by the Company or any entity controlled by the
Company (each, a Business Combination), in each case, provided, however, that, for purposes of this Section 13(f)(ii), a Business Combination will not constitute a Change of Control if following such Business Combination: (A) all or
substantially all of the individuals and entities that were the Beneficial Owners of the Outstanding Company Common Stock and Outstanding Company Voting



20



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##### Table of Contents

Securities immediately prior to such Business Combination beneficially own, directly or indirectly, more than 50% of the then-outstanding shares of common stock and the combined voting power of
the then-outstanding voting securities entitled to vote generally in the election of directors, as the case may be, of the corporation resulting from such Business Combination (including, without limitation, an entity that, as a result of such
transaction, owns the Company or all or substantially all of the Companys assets either directly or through one or more subsidiaries) in substantially the same proportions as their ownership, immediately prior to such Business Combination of
the Outstanding Company Common Stock and Outstanding Company Voting Securities, as the case may be; and (B) no Person (excluding any entity resulting from such Business Combination or any employee benefit plan (or related trust) of the Company or
such entity resulting from such Business Combination) beneficially owns, directly or indirectly, 50% or more of, respectively, the then-outstanding shares of common stock of the corporation resulting from such Business Combination or the combined
voting power of the then-outstanding voting securities of such corporation, except to the extent that such ownership existed prior to the Business Combination; and (C) at least a majority of the members of the board of directors of the entity
resulting from such Business Combination were members of the Board at the time of the execution of the initial agreement, or of the action of the Board, providing for such Business Combination (but excluding any member of the Board whose initial
assumption of office occurs as a result of an actual or threatened election contest with respect to the election or removal of Directors or other actual or threatened solicitation of proxies or consents by or on behalf of a Person other than the
Board; or

(iii) Approval by the shareholders of the Company of a complete liquidation or dissolution of the Company.

Frank C. Condella

Mr. Condellas amended and restated employment agreement, effective May 4, 2010, as amended on March 1, 2011, provides for
the following payments and/or benefits upon termination of his employment:



|                                             |  |                                                                                                                                                                                                                                                                                                                                                                                                        
|-------------------------------------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Type of Termination                          |  | Description of Payments/Benefits                                                                                                                                                                                                                                                                                                                                                                       
|                                             | 
|Death                                        |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; (ii) the pro-rated portion of the $2,000 monthly expense allowance through the effective date of termination; and (iii)
immediate vesting of any unvested restricted stock earned as part of executives annual performance bonus.                                                        
|                                             | 
|Resignation by employee withoutGood Reason   |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; and (ii) the pro-rated portion of the $2,000 monthly expense allowance through the effective date of termination.                                                                                                                                                                         
|                                             | 
|Termination by the Company with Cause        |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; and (ii) the pro-rated portion of the $2,000 monthly expense allowance through the effective date of termination.                                                                                                                                                                         
|                                             | 
|Termination by the Company without Cause     |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; (ii) the pro-rated portion of the $2,000 monthly expense allowance through the effective date of termination; (iii)
immediate vesting of any unvested restricted stock earned as part of executives annual performance bonus; and (iv) vesting of any unvested long-term incentive award.
|                                             | 
|Resignation by the employee with Good Reason |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; (ii) the pro-rated portion of the $2,000 monthly expense allowance through the effective date of termination; (iii)
immediate vesting of any unvested restricted stock earned as part of executives annual performance bonus; and (iv) vesting of any unvested long-term incentive award.



21



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##### Table of Contents

|                                                                                                                                     |  |                                                                                                                                                                                                                                                                                                                                                                                                                                       
|------------------------------------------------------------------------------------------------------------------------------------ |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Termination by the Company without Cause or Resignation by the Employee with Good Reason within six months after a Change of Control |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; (ii) the pro-rated portion of the $2,000 monthly expense allowance through the effective date of termination; (iii)
immediate vesting of any unvested restricted stock earned as part of executives annual performance bonus; (iv) vesting of any unvested long-term incentive award; and (v) six months of base salary.

The employment agreement defines Cause as (i) willful misconduct by the executive which is
seriously harmful to the Companys current and lawful business interests, (ii) executives conviction of a felony or misdemeanor, or (iii) executives refusal to carry out the directives of the Board of Directors.

The employment agreement defines Good Reason as (i) the failure of the Company to comply with any material provision of the
agreement, or (ii) a material reduction in the executives job duties or responsibilities, or (iii) a change in executives job title, or (iv) a change in executives reporting relationship to the Board of Directors, or
(v) a material diminution in executives status within the Company, and the Company has not cured such failure within 30 days after written notice of such noncompliance has been given by executive to the Company, or if such failure is not
capable of being cured in such time, a cure shall not have been diligently initiated by the Company within such 30 calendar day period and the Company shall not have cured such failure within 60 calendar days thereafter.

The employment agreement defines Change of Control as the acquisition of control by an entity, or a group of entities acting
together, of 50% or more of the Companys voting securities with the power to elect a majority of the Board of Directors.

The
following table describes the potential payments and benefits that Mr. Condella would have been entitled to receive under the terms of his employment agreement had his employment terminated on December 31, 2015 and under the terms of our
2015 Plan had a Change of Control (as defined by the 2015 Plan) occurred on December 31, 2015 .



|                                                                                                              |  |                |         |  |          |   |        |                  |  |   |                   |  |  |   |         | 
|------------------------------------------------------------------------------------------------------------- |  | -------------- | ------- |  | -------- | - | ------ | ---------------- |  | - | ----------------- |  |  | - | ------- | 
|                                                                                                              |  | Cash
Severance |         |  | Vacation |   |        | Acceleration of  |  |   | Total
Termination | 
|                                                                                                              |  | Payment(1)     |         |  | Pay(2)   |   |        | Equity Awards(3) |  |   | Benefits          | 
|Death                                                                                                         |  |                | N/A     |  |          | $ | 26,154 |                  |  |   | N/A               |  |  | $ | 26,154  | 
|Resignation by employee without Good Reason                                                                   |  |                | N/A     |  |          | $ | 26,154 |                  |  |   | N/A               |  |  | $ | 26,154  | 
|Termination by the Company with Cause                                                                         |  |                | N/A     |  |          | $ | 26,154 |                  |  |   | N/A               |  |  | $ | 26,154  | 
|Termination by the Company without Cause                                                                      |  |                | N/A     |  |          | $ | 26,154 |                  |  | $ | 401,279           |  |  | $ | 427,433 | 
|Resignation by employee with Good Reason                                                                      |  |                | N/A     |  |          | $ | 26,154 |                  |  | $ | 401,279           |  |  | $ | 427,433 | 
|Termination by the Company without Cause or Resignation by employee for Good Reason after a Change
of Control |  | $              | 170,000 |  |          | $ | 26,154 |                  |  | $ | 401,279           |  |  | $ | 597,433 | 
|Change of Control                                                                                             |  |                | N/A     |  |          |   | N/A    |                  |  | $ | 401,279           |  |  | $ | 401,279 | 



N/ANot
Applicable

|(1) | Payment of the amount of base salary for six months following the date of termination.
|--- | --------------------------------------------------------------------------------------

|(2) | Assumes 20 vacation days. Unused and accrued vacation benefits are paid in a lump sum.
|--- | --------------------------------------------------------------------------------------

|(3) | Represents the intrinsic value of unvested stock options on December 31, 2015, based on the difference between the closing market price of the Companys Common Stock on December 31, 2015 ($10.30) and the
applicable exercise price of all such stock options. Upon vesting, these stock options will be exercisable for 180 days after the date of termination (along with any previously vested stock options awards).
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



22



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##### Table of Contents

George O. Elston

Mr. Elstons employment agreement, effective September 23, 2014, provides for the following payments and/or benefits upon termination
of his employment:



|                                                                                                                                     |  |                                                                                                                                                                                                                                                                                               
|------------------------------------------------------------------------------------------------------------------------------------ |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Type of Termination                                                                                                                  |  | Description of Payments/Benefits                                                                                                                                                                                                                                                              
|                                                                                                                                     | 
|Death                                                                                                                                |  | Base salary through the effective date of termination together with any accrued but unused vacation pay.                                                                                                                                                                                      
|                                                                                                                                     | 
|Resignation by employee without Good Reason                                                                                          |  | Base salary through the effective date of termination together with any accrued but unused vacation pay.                                                                                                                                                                                      
|                                                                                                                                     | 
|Termination by the Company with Cause                                                                                                |  | Base salary through the effective date of termination together with any accrued but unused vacation pay.                                                                                                                                                                                      
|                                                                                                                                     | 
|Termination by the Company without Cause                                                                                             |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; (ii) six months of base salary; and (iii) an amount equal to six months of the Companys portion of medical and dental
benefits if these benefits were elected.                  
|                                                                                                                                     | 
|Resignation by the employee with Good Reason                                                                                         |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; (ii) six months of base salary; and (iii) an amount equal to six months of the Companys portion of medical and dental
benefits if these benefits were elected.                  
|                                                                                                                                     | 
|Termination by the Company without Cause or Resignation by the Employee with Good Reason within six months after a Change of Control |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; (ii) six months of base salary and accrued bonus; and (iii) an amount equal to six months of the Companys portion of
medical and dental benefits if these benefits were elected.

The employment agreement defines Good Reason as: (i) a material breach of the employment
agreement by the Company or (ii) a material reduction in Mr. Elstons responsibilities, authority or duties as outlined in the employment agreement.

The employment agreement defines Cause as (i) willful misconduct by the executive which is seriously harmful to the
Companys current and lawful business interests, (ii) executives conviction of a felony or misdemeanor, or (iii) executives refusal to carry out the directives of the Companys chief executive officer.

The employment agreement defines Change of Control as the acquisition of control by an entity, or a group of entities acting
together, of 50% or more of the Companys voting securities with the power to elect a majority of the Board of Directors.



23



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##### Table of Contents

The following table describes the potential payments and benefits that Mr. Elston would have
been entitled to receive under the terms of his employment agreement had his employment terminated on December 31, 2015 and under the terms of our 2015 Plan had a Change of Control (as defined by the 2015 Plan) occurred on December 31, 2015 .



|                                                                                                              |  |                |         |  |          |   |        |                                          |  |  |                                  |  |  |                   |         |  |  |   |         | 
|------------------------------------------------------------------------------------------------------------- |  | -------------- | ------- |  | -------- | - | ------ | ---------------------------------------- |  |  | -------------------------------- |  |  | ----------------- | ------- |  |  | - | ------- | 
|                                                                                                              |  | Cash
Severance |         |  | Vacation |   |        | Continuation of
Medical/Welfare Benefits |  |  | Acceleration and
Continuation of |  |  | Total
Termination |        
|                                                                                                              |  | Payment(1)     |         |  | Pay(2)   |   |        | (present value)                          |  |  | Equity Awards(3)                 |  |  | Benefits          |        
|Death                                                                                                         |  |                | N/A     |  |          | $ | 23,077 |                                          |  |  | N/A                              |  |  |                   | N/A     |  |  | $ | 23,077  | 
|Resignation by employee without Good Reason                                                                   |  |                | N/A     |  |          | $ | 23,077 |                                          |  |  | N/A                              |  |  |                   | N/A     |  |  | $ | 23,077  | 
|Termination by Company with Cause                                                                             |  |                | N/A     |  |          | $ | 23,077 |                                          |  |  | N/A                              |  |  |                   | N/A     |  |  | $ | 23,077  | 
|Termination by the Company without Cause or                                                                   |  | $              | 150,000 |  |          | $ | 23,077 |                                          |  |  | 5,910                            |  |  |                   | N/A     |  |  | $ | 178,987 | 
|Resignation by employee with Good Reason                                                                      |  | $              | 150,000 |  |          | $ | 23,077 |                                          |  |  | 5,910                            |  |  |                   | N/A     |  |  | $ | 178,987 | 
|Termination by the Company without Cause or Resignation by employee for Good Reason after a Change
of Control |  | $              | 150,000 |  |          | $ | 23,077 |                                          |  |  | 5,910                            |  |  |                   | N/A     |  |  | $ | 178,987 | 
|Change of Control                                                                                             |  |                | N/A     |  |          |   | N/A    |                                          |  |  | N/A                              |  |  | $                 | 324,750 |  |  | $ | 324,750 | 



N/ANot
Applicable

|(1) | Payment of the amount of base salary for six months following the date of termination.
|--- | --------------------------------------------------------------------------------------

|(2) | Assumes 20 vacation days. Unused and accrued vacation benefits are paid in a lump sum.
|--- | --------------------------------------------------------------------------------------

|(3) | Represents the intrinsic value of both vested and unvested stock options on December 31, 2015, based on the difference between the closing market price of the Companys Common Stock on December 31, 2015
($10.30) and the applicable exercise price of all such stock options. Upon vesting, these stock options will be exercisable for 180 days after the date of termination (along with any previously vested stock option awards).
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Dr. Patel

Dr. Patels employment agreement provides for severance in the event the Company elects to terminate his employment with less than
six months prior written notice. Had the Company elected to terminate his employment on December 31, 2015, with no prior written notice, Dr. Patel would have been entitled to receive £101,14 (or $149,721), the equivalent of six
months of base salary.

In addition, had a Change of Control (as defined under the 2015 Plan) occurred on December 31, 2015, Dr.
Patels outstanding equity awards (with an intrinsic value of $255,680) would have become immediately and fully vested and exercisable.



24



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##### Table of Contents

Dr. Martell

Dr. Martells employment agreement, effective January 5, 2015, provides for the following payments and/or benefits upon termination of his
employment:



|                                                                                                                                     |  |                                                                                                                                                                                                                                                                                               
|------------------------------------------------------------------------------------------------------------------------------------ |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Type of Termination                                                                                                                  |  | Description of Payments/Benefits                                                                                                                                                                                                                                                              
|                                                                                                                                     | 
|Death                                                                                                                                |  | Base salary through the effective date of termination together with any accrued but unused vacation pay.                                                                                                                                                                                      
|                                                                                                                                     | 
|Resignation by employee without Good Reason                                                                                          |  | Base salary through the effective date of termination together with any accrued but unused vacation pay.                                                                                                                                                                                      
|                                                                                                                                     | 
|Termination by the Company with Cause                                                                                                |  | Base salary through the effective date of termination together with any accrued but unused vacation pay.                                                                                                                                                                                      
|                                                                                                                                     | 
|Termination by the Company without Cause                                                                                             |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; (ii) six months of base salary; and (iii) an amount equal to six months of the Companys portion of medical and dental
benefits if these benefits were elected.                  
|                                                                                                                                     | 
|Resignation by the employee with Good Reason                                                                                         |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; (ii) six months of base salary; and (iii) an amount equal to six months of the Companys portion of medical and dental
benefits if these benefits were elected.                  
|                                                                                                                                     | 
|Termination by the Company without Cause or Resignation by the Employee with Good Reason within six months after a Change of Control |  | (i) Base salary through the effective date of termination together with any accrued but unused vacation pay; (ii) six months of base salary and accrued bonus; and (iii) an amount equal to six months of the Companys portion of
medical and dental benefits if these benefits were elected.

The employment agreement defines Good Reason as: (i) a material breach of the employment
agreement by the Company, (ii) a material reduction in Dr. Martells responsibilities, authority or duties as outlined in the employment agreement, or (iii) a requirement for permanent relocation.

The employment agreement defines Cause as (i) willful misconduct by the executive which is seriously harmful to the
Companys current and lawful business interests, (ii) executives conviction of a felony or misdemeanor, or (iii) executives refusal to carry out the directives of the Companys chief executive officer.

The employment agreement defines Change of Control as the acquisition of control by an entity, or a group of entities acting
together, of 50% or more of the Companys voting securities with the power to elect a majority of the Board of Directors.



25



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##### Table of Contents

The following table describes the potential payments and benefits that Dr. Martell would have
been entitled to receive under the terms of her employment agreement had her employment terminated on December 31, 2015 and under the terms of our 2015 Plan had a Change of Control occurred on December 31, 2015.



|                                                                                                              |  |                         |         |  |                |   |        |                                                       |  |   |                                                 |  |  |                          |         |  |  |   |         | 
|------------------------------------------------------------------------------------------------------------- |  | ----------------------- | ------- |  | -------------- | - | ------ | ----------------------------------------------------- |  | - | ----------------------------------------------- |  |  | ------------------------ | ------- |  |  | - | ------- | 
|                                                                                                              |  | CashSeverancePayment(1) |         |  | VacationPay(2) |   |        | Continuation ofMedical/WelfareBenefits(present value) |  |   | Acceleration andContinuation ofEquity Awards(3) |  |  | TotalTerminationBenefits |        
|Death                                                                                                         |  |                         | N/A     |  |                | $ | 21,538 |                                                       |  |   | N/A                                             |  |  |                          | N/A     |  |  | $ | 21,538  | 
|Resignation by employee without Good Reason                                                                   |  |                         | N/A     |  |                | $ | 21,538 |                                                       |  |   | N/A                                             |  |  |                          | N/A     |  |  | $ | 21,538  | 
|Termination by Company with Cause                                                                             |  |                         | N/A     |  |                | $ | 21,538 |                                                       |  |   | N/A                                             |  |  |                          | N/A     |  |  | $ | 21,538  | 
|Termination by the Company without Cause or                                                                   |  | $                       | 140,000 |  |                | $ | 21,538 |                                                       |  | $ | 5,910                                           |  |  |                          | N/A     |  |  | $ | 167,448 | 
|Resignation by employee with Good Reason                                                                      |  | $                       | 140,000 |  |                | $ | 21,538 |                                                       |  | $ | 5,910                                           |  |  |                          | N/A     |  |  | $ | 167,448 | 
|Termination by the Company without Cause or Resignation by employee for Good Reason after a Change
of Control |  | $                       | 140,000 |  |                | $ | 21,538 |                                                       |  | $ | 5,910                                           |  |  |                          | N/A     |  |  | $ | 167,448 | 
|Change of Control                                                                                             |  |                         | N/A     |  |                |   | N/A    |                                                       |  |   | N/A                                             |  |  | $                        | 280,200 |  |  | $ | 280,200 | 



N/ANot
Applicable

|(1) | Payment of the amount of base salary for six months following the date of termination.
|--- | --------------------------------------------------------------------------------------

|(2) | Assumes 20 vacation days. Unused and accrued vacation benefits are paid in a lump sum.
|--- | --------------------------------------------------------------------------------------

|(3) | Represents the intrinsic value of both vested and unvested stock options on December 31, 2015, based on the difference between the closing market price of the Companys Common Stock on December 31, 2015
($10.30) and the applicable exercise price of all such stock options. Upon vesting, these stock options will be exercisable for 180 days after the date of termination (along with any previously vested stock option awards).
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Director Compensation Program for 2015

The Company currently provides to non-employee directors reimbursement for expenses and the following compensation. A Board Chair who also
serves as a committee Chair does not receive the committee Chair retainer.



|                                            |  |   |        | 
|------------------------------------------- |  | - | ------ | 
|Annual Director Retainer                    |  | $ | 40,000 | 
|Additional Annual Retainer, Board Chair     |  | $ | 30,000 | 
|Additional Annual Retainer, Committee Chair |  | $ | 15,000 | 
|Annual Equity Award (1)                     |  | $ | 30,000 | 



|(1) | Consists of a grant of the number of shares of restricted stock under the Companys Long-Term Performance Plan determined by dividing $30,000 by the fair market value of the Companys Common Stock on the date
of grant. Provided, however, if an insufficient number of shares of restricted stock are available for issuance under the Companys 2015 Plan, the balance of the value will consist of a grant of stock options to purchase shares of the
Companys Common Stock at the fair market value of the Companys Common Stock on the date of grant determined by dividing the balance of the value by the fair value of a stock option on that date using the Black-Scholes option pricing
model. The restricted stock and stock options vest at the next annual meeting of stockholders.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



26



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##### Table of Contents

2015 Director Compensation

Directors who are employees (Mr. Condella and Dr. Patel), receive no additional compensation for serving on the Board. In 2015, we
provided the following annual compensation to our non-employee directors.



|                       |  |                                   |        |  |                   |   |        |                 |  |   |          |     |  |   |         | 
|---------------------- |  | --------------------------------- | ------ |  | ----------------- | - | ------ | --------------- |  | - | -------- | --- |  | - | ------- | 
|Name of
Director(1)    |  | Fees Earned andPaid in Cash(2)($) |        |  | StockAwards(3)($) |   |        | OptionAwards($) |  |   | Total($) |    
|Valerie Andrews(4)     |  | $                                 | 27,500 |  |                   | $ |       |                 |  | $ |         |     |  | $ | 27,500  | 
|Dr. Frank M. Armstrong |  | $                                 | 47,500 |  |                   | $ | 30,000 |                 |  | $ |         |     |  | $ | 77,500  | 
|Cristina Csimma        |  | $                                 | 40,000 |  |                   | $ | 30,000 |                 |  | $ |         |     |  | $ | 70,000  | 
|James A. Geraghty      |  | $                                 | 38,736 |  |                   | $ | 33,462 |                 |  | $ | 317,878  | (5) |  | $ | 390,076 | 
|Donald H. Hunter(6)    |  | $                                 | 55,000 |  |                   | $ | 30,000 |                 |  | $ |         |     |  | $ | 85,000  | 
|Stephen Kasnet(7)      |  | $                                 | 36,332 |  |                   | $ |       |                 |  | $ |         |     |  | $ | 36,332  | 
|Ann Merrifield         |  | $                                 | 20,000 |  |                   | $ | 30,000 |                 |  | $ |         |     |  | $ | 50,000  | 



|(1) | Dr. Gray did not join the Board until March 2016 and is, therefore, not included in this table.
|--- | -----------------------------------------------------------------------------------------------

|(2) | This column reports the amount of cash compensation earned or paid in 2015 for Board and committee service.
|--- | -----------------------------------------------------------------------------------------------------------

|(3) | This column represents the aggregate grant date fair value of awards of restricted stock granted during the 2015 fiscal year, computed in accordance with ASC Topic 718. The aggregate grant date fair value for the
restricted stock awards granted to each director upon his or her reelection to the Board at the 2015 Annual Meeting of Stockholders was $30,000. The number of shares underlying each such award was determined by dividing $30,000 by the fair market
value of the Companys Common Stock on the date of the grant.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

In addition Mr. Geraghty received a pro-rated grant of
restricted stock for his Board service beginning on the date he joined the Board to the date of the 2015 annual meeting of stockholders.



|(4) | Ms. Andrews resigned from the Board on July 7, 2015.
|--- | ----------------------------------------------------

|(5) | Represents the aggregate grant date fair value of a stock option award grated to Mr. Geraghty upon his joining the Board, computed in accordance with ASC Topic 718.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Mr. Hunter resigned from the Board, effective March 23, 2016.
|--- | -------------------------------------------------------------

|(7) | Mr. Kasnet did not stand for reelection at the 2015 annual meeting of stockholders.
|--- | -----------------------------------------------------------------------------------



27



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##### Table of Contents

The aggregate total number of shares underlying stock option awards and restricted stock awards
outstanding at 2015 fiscal year-end for the non-employee directors are shown below:



|                       |  |                                    |        |  |                            |  |       | 
|---------------------- |  | ---------------------------------- | ------ |  | -------------------------- |  | ----- | 
|Name(1)                |  | Number of SharesUnderlying Options |        |  | Number ofRestricted Shares | 
|Valerie Andrews(2)     |  |                                    |       |  |                            |  |      | 
|Dr. Frank M. Armstrong |  |                                    |       |  |                            |  | 2,529 | 
|Cristina Csimma        |  |                                    |       |  |                            |  | 2,529 | 
|James A. Geraghty      |  |                                    | 70,000 |  |                            |  | 2,529 | 
|Donald H. Hunter(3)    |  |                                    |       |  |                            |  | 2,529 | 
|Stephen Kasnet(4)      |  |                                    |       |  |                            |  |      | 
|Ann Merrifield         |  |                                    |       |  |                            |  | 2,529 | 



|(1) | Dr. Gray did not join the Board until March 2016 and is, therefore, not included in this table.
|--- | -----------------------------------------------------------------------------------------------

|(2) | Ms. Andrews resigned from the Board on July 7, 2015.
|--- | ----------------------------------------------------

|(3) | Mr. Hunter resigned from the Board, effective March 23, 2016.
|--- | -------------------------------------------------------------

|(4) | Mr. Kasnet did not stand for reelection at the 2015 annual meeting of stockholders.
|--- | -----------------------------------------------------------------------------------

Compensation
Committee Interlocks and Insider Participation

None of the Companys executive officers served during fiscal year 2015 or
currently serve, and the Company anticipates that none will serve, as a member of the Board of Directors or compensation committee of any entity (other than the Company) that has one or more executive officers that serves on the Companys Board
or the Compensation Committee.

Compensation Committee Report

The Compensation Committee evaluates and establishes compensation for executive officers and oversees the Companys compensation
policies, the Long-term Performance Plans, Incentive Plan, and other benefit programs. Management has the primary responsibility for the Companys financial statements and reporting process, including the disclosure of executive compensation.
We have reviewed and discussed with management the Compensation Discussion and Analysis. Based on the review and discussion with management, the Compensation Committee recommended to the Board of Directors that the Compensation Discussion and
Analysis should be included in this report.



COMPENSATION COMMITTEE:Dr. Frank M. Armstrong, ChairDr. Cristina CsimmaAnn Merrifield




28



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##### Table of Contents

|Item 12. | Security Ownership of Certain Beneficial Owners and Management and Related StockholderMatters
|-------- | ---------------------------------------------------------------------------------------------

Common Stock. The following table sets forth, as of April 21, 2016, information with respect to the beneficial ownership of Junipers Common Stock
by:



| |  |  | each person known to us to be the beneficial owner of more than 5% of Junipers Common Stock;
| | - |  | ---------------------------------------------------------------------------------------------



| |  |  | each of Junipers directors and director nominees;
| | - |  | --------------------------------------------------



| |  |  | each of the individuals included in the Summary Compensation Table (collectively, the named executive officers); and
| | - |  | ----------------------------------------------------------------------------------------------------------------------



| |  |  | all of Junipers current directors and executive officers as a group.
| | - |  | ---------------------------------------------------------------------

The number of
shares beneficially owned by each person, director, director nominee, or named executive officer is determined under rules of the SEC; this information is not necessarily indicative of beneficial ownership for any other purpose. Under these rules,
beneficial ownership includes any shares for which the individual has sole or shared voting power or investment power and also any shares with respect to which the person has the right to acquire sole or shared voting or investment power on or
before June 20, 2016 (60 days after April 21, 2016) through the conversion of shares of convertible preferred stock or the exercise of any stock option, warrant or other right. Unless we indicate otherwise, each person has sole investment
and/or voting power with respect to the shares set forth in the following tables.



|                                                                              |  |                                       |           |  |                       |  |      |  
|----------------------------------------------------------------------------- |  | ------------------------------------- | --------- |  | --------------------- |  | ---- | -
|Name and Address of Beneficial Owner                                          |  | Number of SharesBeneficially Owned(1) |           |  | Percentage ofTotal(1) | 
|                                                                              |  |                                      
|5% Stockholders:                                                              |  |                                       |           |  |                       |  |      |  
|BlackRock, Inc.(2)                                                            |  |                                       | 620,317   |  |                       |  | 5.7  | %
|                                                                              |  |                                      
|Directors and Named Executive Officers:                                       |  |                                       |           |  |                       |  |      |  
|Dr. Frank M. Armstrong(4)                                                     |  |                                       | 12,241    |  |                       |  |      | *
|Frank C. Condella, Jr.(3)(4)                                                  |  |                                       | 265,967   |  |                       |  | 2.5  | %
|Dr. Cristina Csimma(4)                                                        |  |                                       | 21,135    |  |                       |  |      | *
|George O. Elston(3)(4)                                                        |  |                                       | 18,750    |  |                       |  |      | *
|James A. Geraghty(3)(4)                                                       |  |                                       | 66,872    |  |                       |  |      | *
|Dr. Mary Ann Gray(4)                                                          |  |                                       | 1,270     |  |                       |  |      | *
|Dr. Bridget Martell(3)(4)                                                     |  |                                       | 15,000    |  |                       |  |      | *
|Ann Merrifield(4)                                                             |  |                                       | 7,129     |  |                       |  |      | *
|Dr. Nikin Patel(3)(4)                                                         |  |                                       | 215,384   |  |                       |  | 2.0  | %
|All 5% Stockholders, Directors and Executive Officers as a Group (10 persons) |  |                                       | 1,244,065 |  |                       |  | 11.5 | %



|* | Signifies less than 1%
|- | ----------------------

|(1) | Based on 10,802,819 shares outstanding at April 21, 2016. In calculating the percentage of ownership, all shares of Common Stock of which the identified person or group has the right to acquire beneficial ownership on
or before June 20, 2016, are deemed to be outstanding for the purpose of computing the percentage of the shares of Common Stock owned by that person or group. These shares are not, however, deemed to be outstanding for the purpose of computing the
percentage of the shares of Common Stock owned by any other person or group.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Based upon information contained in a Schedule 13G filed with the SEC on January 28, 2016 by BlackRock, Inc. According to the Schedule 13G, BlackRock, Inc. has sole voting power with respect to 609,117 shares and sole
dispositive power with respect to 620,317 shares. The address of BlackRock, Inc. is 55 East 52nd Street, New York, NY 10055.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

|(3) | Includes shares of Common Stock that may be acquired upon the exercise of options exercisable within 60 days after April 21, 2016, as follows: Mr. Condella, 186,247 shares; shares; Mr. Elston, 18,750 shares;
Mr. Geraghty, 23,332 shares; Dr. Martell, 15,000 shares; and Dr. Patel, 26,000 shares.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(4) | Address: c/o Juniper Pharmaceuticals, Inc., 33 Arch Street, Suite 3110, Boston, Massachusetts 02110.
|--- | ----------------------------------------------------------------------------------------------------

Series B Preferred Stock. Michael Nissan and Marla S. Nissan of 876 Park Avenue, New York, New York 10021, hold all 130 outstanding
shares of the Series B Preferred Stock as of April 21, 2016.

Equity Compensation Plan Information

The following table sets forth aggregate information for the fiscal year ended December 31, 2015, regarding the Companys compensation
plans, including individual compensation agreements, under which equity securities of the Company are authorized for issuance:



|                                                           |  |                                                                                          |           |  |                                                                          |   |      |                                                                                                                                        |  |  |         | 
|---------------------------------------------------------- |  | ---------------------------------------------------------------------------------------- | --------- |  | ------------------------------------------------------------------------ | - | ---- | -------------------------------------------------------------------------------------------------------------------------------------- |  |  | ------- | 
|Plan Category                                              |  | Number of securities tobe issued upon exerciseof outstanding options,warrants and
rights |           |  | Weighted averageexercise price ofoutstanding options,warrants and rights |   |      | Number of securities remainingavailable for future issuanceunder
equitycompensation plans(excluding securities reflectedin column (a)) | 
|                                                           |  | (a)                                                                                      |           |  | (b)                                                                      |   |      | (c)                                                                                                                                    | 
|                                                           |  |                                                                                          |          
|Equity compensation plans approved by security holders     |  |                                                                                          | 1,019,684 |  |                                                                          | $ | 7.30 |                                                                                                                                        |  |  | 745,375 | 
|Equity compensation plans not approved by security holders |  |                                                                                          |          |  |                                                                          | $ |     |                                                                                                                                        |  |  |        | 
|                                                           |  |                                                                                          |           |  |                                                                          |   |      |                                                                                                                                        |  |  |         | 
|Total                                                      |  |                                                                                          | 1,019,684 |  |                                                                          | $ | 7.30 |                                                                                                                                        |  |  | 745,375 | 

The Company has three shareholder-approved equity compensation plans. The 1996 Long-Term Performance Plan
(the 1996 Plan), adopted in October 1996, provided for the grant of stock options, stock appreciation rights and restricted stock to certain designated employees of the Company, non-employee directors of the Company and certain other
persons performing significant services for the Company as designated by the Compensation Committee of the Board of Directors. On May 13, 2008, the stockholders of the Company approved the 2008 Long-Term Incentive Plan (the 2008
Plan), which was subsequently amended at the 2013 annual meeting of stockholders. The 2008 Plan, as amended, provides for the grant of stock options, stock appreciation rights and restricted stock to certain designated employees of the
Company, non-employee directors of the Company and certain other persons performing significant services for the Company as designated by the Compensation Committee. Upon approval of the 2008 Plan, the Company stopped making grants under the 1996
Plan. On July 7, 2015, the stockholders of the Company approved the 2015 Plan. Upon approval of the 2015 Plan, the Company stopped making grants under the 2008 Plan.



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##### Table of Contents

|Item 13. | Certain Relationships and Related Transactions, and Director Independence
|-------- | -------------------------------------------------------------------------

Director Independence

The Board has
analyzed the independence of each director who served on the Board during 2015 and has determined that, with the exception of Mr. Condella and Dr. Patel, each director qualifies as an independent director under the applicable Nasdaq
Marketplace Rules, including that each such director is free (or was free) of any relationship that would interfere with his or her individual exercise of independent judgment. All of the Companys committees are comprised solely of independent
directors.

Certain Relationships and Related Party Transactions

We have a policy against our directors, officers, employees, and consultants entering into transactions that present actual or potential
conflicts of interests. A conflict of interest can arise when a director, officer, employee, or consultant takes an action or has an interest that may make it difficult for him or her to perform his or her work objectively and effectively. Conflicts
of interest may also arise when a director, officer, employee, or consultant (or his or her family members) receives improper personal benefits as a result of the directors, officers, employees, or consultants relationship to
us. This policy is reflected in our Code of Business Conduct and Ethics. In addition, the Audit Committee of the Board, pursuant to its charter, is responsible for reviewing and addressing conflicts of interest of directors and executive officers;
as well as monitoring and reviewing (including discussing with management and the independent auditor) and, if appropriate, recommending to the full Board the approval or ratification of any transactions or courses of dealing with related parties
that are required to be disclosed pursuant to SEC Regulation S-K, Item 404.



|Item 14. | Principal Accountant Fees and Services
|-------- | --------------------------------------

The following table sets forth the aggregate fees billed to the Company by BDO for the fiscal years ended December 31, 2015 and 2014:



|                      |  |      |         |  |      |   |         | 
|--------------------- |  | ---- | ------- |  | ---- | - | ------- | 
|                      |  | 2015 |         |  | 2014 |  
|Audit Fees(1)         |  | $    | 639,795 |  |      | $ | 663,989 | 
|Audit-Related Fees(2) |  |      |        |  |      |   |        | 
|Tax Fees(3)           |  |      | 30,900  |  |      |   | 30,435  | 
|                      |  |      |         |  |      |   |         | 
|Total                 |  | $    | 670,695 |  |      | $ | 694,424 | 



|(1) | Audit fees consisted of fees for audit work performed in the audit of financial statements, as well as fees for quarterly reviews and registration statements.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Audit-related fees consisted principally of fees for consulting on financial accounting and reporting standards for certain transactions and related matters.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Tax fees consisted principally of fees for work performed with respect to tax compliance and tax planning.
|--- | ----------------------------------------------------------------------------------------------------------

The Audit Committee has adopted a formal policy on auditor independence requiring the advance approval by the Audit Committee of all audit
and non-audit services provided by our independent registered public accounting firm. In determining whether to approve any services by our independent registered public accounting firm, the Audit Committee reviews the services and the estimated
fees, and considers whether approval of the proposed services will have a detrimental impact on the auditors independence. On an annual basis, our management reports to the Audit Committee all audit and non-audit services performed during the
previous 12 months and all fees billed by our independent registered public accounting firm for such services.

In fiscal 2015 and 2014,
all audit, audit related and non-audit services and the corresponding fees were approved by the Audit Committee.



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##### Table of Contents

PART IV



|Item 15. | Exhibits and Financial Statement Schedules
|-------- | ------------------------------------------



|        |  |                                                                                                                                                                                                                                                                                                                     
|------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit |  | Index Description of Exhibit                                                                                                                                                                                                                                                                                        
|        | 
|2.1     |  | Purchase and Collaboration Agreement, dated March 3, 2010, by and between Juniper Pharmaceuticals, Inc. and Coventry Acquisition, Inc. (incorporated by reference to Exhibit 2.1 to the Registrants Current Report on Form
8-K (File No. 001-10352), filed on March 4, 2010)                                       
|        | 
|2.2     |  | Share Purchase Agreement, dated September 2013, between the Sellers, Juniper Pharmaceuticals, Inc. and Juniper Pharma Services Limited (incorporated by reference to Exhibit 2.1 to the Registrants Current Report on Form
8-K (File No. 001-10352), filed on September 18, 2013)                                  
|        | 
|2.3     |  | Stock Purchase Agreement, dated March 6, 2014, by and between Juniper Pharmaceuticals, Inc. and Coventry Acquisition, Inc. (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on Form 8-K (File No.
001-10352), filed on March 7, 2014)                                                  
|        | 
|3.1     |  | Restated Certificate of Incorporation of the Company, as amended (incorporated by reference to Exhibit 3.1 to the Registrants Annual Report on Form 10-K (File No. 001-10352) for the year
ended December 31, 2005, filed on March 13, 2006)                                                                       
|        | 
|3.2     |  | Certificate of Amendment of Restated Certificate of Incorporation of the Company (incorporated by reference to Exhibit 3.1 to the Registrants Current Report on Form 8-K (File No.
001-10352), filed on July 6, 2010)                                                                                              
|        | 
|3.3     |  | Certificate of Amendment of Restated Certificate of Incorporation of the Company (incorporated by reference to Exhibit 3.1 to the Registrants Current Report on Form 8-K (File No.
001-10352), filed on August 8, 2013)                                                                                            
|        | 
|3.4     |  | Certificate of Amendment of Restated Certificate of Incorporation of the Company (incorporated by reference to Exhibit 3.1 to the Registrants Current Report on Form 8-K (File No.
001-10352), filed on April 3, 2015)                                                                                             
|        | 
|3.5     |  | Amended and Restated By-laws of Company (incorporated by reference to Exhibit 3.2 to the Registrants Current Report on Form 8-K (File No. 001-10352), filed on January 12,
2015)                                                                                                                                   
|        | 
|3.6     |  | Amendment No. 1 to the Amended and Restated By-laws of the Company (incorporated by reference to Exhibit 3.2 to the Registrants Current Report on Form 8-K (File No. 001-10352),
filed on April 3, 2015)                                                                                                           
|        | 
|4.1     |  | Certificate of Designations, Preferences and Rights of Series C Convertible Preferred Stock of the Company, dated as of January 7, 1999 (incorporated by reference to Exhibit 4.1 to the Registrants Annual Report on Form 10-K
(File No. 001-10352) for the year ended December 31, 1998, filed on March 25, 1999)
|        | 
|4.2*    |  | Form of Option Agreement (incorporated by reference to Exhibit 4.10 to the Registrants Annual Report on Form 10-K (File No. 001-10352) for the year ended December 31, 2008, filed on March 16, 2009)                                                                                                              
|        | 
|4.3     |  | Amended and Restated Rights Agreement by and between Juniper Pharmaceuticals, Inc. and American Stock Transfer & Trust Company, LLC dated January 28, 2015 (incorporated by reference to Exhibit 4.1 to the Registrants
Current Report on Form 8-K (File No. 001-10352), filed on January 30, 2015)                
|        | 
|10.1*   |  | 1996 Long-term Performance Plan, as amended, of the Company (incorporated by reference to Annex A to the Registrants Proxy Statement (File No. 001-10352), filed on May 10,
2000)                                                                                                                                  
|        | 
|10.2*   |  | Form of Restricted Stock Agreement under the 1996 Long-Term Performance Plan (incorporated by reference to Exhibit 10.62 of the Registrants Current Report on Form 8-K (File No.
001-10352), filed on May 17, 2006)                                                                                                



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|        |  |                                                                                                                                                                                                                                                                                                                                    
|------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit |  | Index Description of Exhibit                                                                                                                                                                                                                                                                                                       
|        | 
|10.3    |  | License Agreement, dated April 18, 2000, between the Company and Lil Drug Store Products, Inc. (incorporated by reference to Exhibit 10.23 to the Registrants Quarterly Report on Form 10-Q (File No. 001-10352) for the quarter ended March 31, 2000, filed on May 15, 2000)                                                    
|        | 
|10.4*   |  | Form of Indemnification Agreement for Officers and Directors (incorporated by reference to Exhibit 10.46 to the Registrants Annual Report on Form 10-K (File No. 001-10352) for the year ended December 31, 2003, filed on
March 15, 2004)                                                                                        
|        | 
|10.5    |  | Packaging Agreement, dated October 28, 1993, between Juniper Pharmaceuticals (Ireland) Ltd. and Maropack AG (incorporated by reference to Exhibit 10.32 to the Registrants Annual Report on Form 10-K (File No. 001-10352) for the year ended December 31, 2007, filed on March 28, 2008)                                         
|        | 
|10.6*   |  | Juniper Pharmaceuticals, Inc. Amended and Restated 2008 Long-Term Incentive Plan (incorporated by reference to Appendix B to the Registrants Proxy Statement (File No. 001-10352), filed on March 22, 2013)                                                                                                                       
|        | 
|10.7*   |  | Form of Award Agreement under the Amended and Restated 2008 Long-term Incentive Plan of Juniper Pharmaceuticals, Inc. (incorporated by reference to Exhibit 4.4 to the Registrants Registration Statement on Form S-8 (File No. 333-18647), filed on May 16, 2013)                                                                
|        | 
|10.8*   |  | Juniper Pharmaceuticals, Inc. 2015 Long-Term Incentive Plan (incorporated by reference to Exhibit 4.5 to the Registrants Registration Statement on Form S-8 (File No. 333-205723), filed
on July 17, 2015)                                                                                                                        
|        | 
|10.9*   |  | Form of Nonqualified Stock Option Award Agreement under the Juniper Pharmaceuticals, Inc. 2015 Long-Term Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrants Quarterly Report on Form 10-Q (File No.
001-10352), filed on August 4, 2015)                                                                
|        | 
|10.10*  |  | Form of Incentive Stock Option Award Agreement under the Juniper Pharmaceuticals, Inc. 2015 Long-Term Incentive Plan (incorporated by reference to Exhibit 10.2 to the Registrants Quarterly Report on Form 10-Q (File No. 001-10352), filed on August 4, 2015)                                                                   
|        | 
|10.11*  |  | Form of Restricted Stock Award Agreement under the Juniper Pharmaceuticals, Inc. 2015 Long-Term Incentive Plan (incorporated by reference to Exhibit 10.3 to the Registrants Quarterly Report on Form 10-Q (File No. 001-10352),
filed on August 4, 2015)                                                                         
|        | 
|10.12*  |  | Form of Executive Change of Control Severance Agreement (incorporated by reference to Exhibit 10.25 to the Registrants Annual Report on Form 10-K (File No. 001-10352) for the year ended December 31, 2008, filed on
March 16, 2009)                                                                                             
|        | 
|10.13   |  | Manufacturing and Supply Agreement, dated December 8, 2009, between Fleet Laboratories and Juniper Pharmaceuticals (Bermuda), Ltd. (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on Form 8-K
(File No. 001-10352), filed on December 9, 2009)                                                      
|        | 
|10.14   |  | Note Purchase and Amendment Agreement, dated March 3, 2010, by and between Juniper Pharmaceuticals, Inc. and holders listed on Schedule I thereto (incorporated by reference to Exhibit 10.1 to the Registrants Current
Report on Form 8-K (File No. 001-10352), filed on March 4, 2010)                                          
|        | 
|10.15*  |  | Amended and Restated Employment Agreement, dated May 4, 2010, by and between Juniper Pharmaceuticals, Inc. and Frank C. Condella, Jr. (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on Form
8-K (File No. 001-10352), filed on May 5, 2010)                                                        
|        | 
|10.16*  |  | Addendum to Amended and Restated Employment Agreement, dated March 1, 2011, by and between Juniper Pharmaceuticals, Inc., and Frank C. Condella, Jr. (incorporated by reference to Exhibit 10.46 to the Registrants Annual
Report on Form 10-K (File No. 001-10352) for the year ended December 31, 2010, filed on March 10, 2011)
|        | 
|10.17   |  | Second Amended and Restated License and Supply Agreement, dated May 14, 2010, between Juniper Pharmaceuticals, Inc. and Ares Trading S.A. (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on
Form 8-K (File No. 001-10352), filed on May 18, 2010)                                                   



33



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##### Table of Contents

|        |  |                                                                                                                                                                                                                                                                                                                                                        
|------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit |  | Index Description of Exhibit                                                                                                                                                                                                                                                                                                                           
|        | 
|10.18   |  | Amendment No. 1 to the Second Amended and Restated License and Supply Agreement, dated April 4, 2013, between Juniper Pharmaceuticals, Inc. and Ares Trading S.A. (incorporated by reference to Exhibit 10.1 to the
Registrants Current Report on Form 8-K (File No. 001-10352), filed on April 9, 2013)                                              
|        | 
|10.19   |  | Parent Guarantee of Juniper Pharmaceuticals, Inc., dated September 12, 2013 (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on Form 8-K (File No. 001-10352), filed on September 18,
2013)                                                                                                                               
|        | 
|10.20*  |  | Employment Agreement, dated September 12, 2013, between Dr. Nikin Patel and Juniper Pharmaceuticals, Inc. (incorporated by reference to Exhibit 10.2 to the Registrants Current Report on Form 8-K (File No. 001-10352),
filed on September 18, 2013)                                                                                                 
|        | 
|10.21   |  | Bank Loan Agreement, dated January 6, 2012, between Juniper Pharma Services Limited and Lloyds TSB Bank plc (incorporated by reference to Exhibit 10.3 the Registrants Quarterly Report on Form 10-Q (File No. 001-10352) for the quarter ended September 30, 2013, filed on November 7, 2013)                                                        
|        | 
|10.22   |  | Amendment letter, dated September 16, 2013, between Juniper Pharma Services Limited and Lloyds TSB Bank plc (incorporated by reference to Exhibit 10.4 the Registrants Quarterly Report on Form 10-Q (File No. 001-10352) for the quarter ended September 30, 2013, filed on November 7, 2013)                                                        
|        | 
|10.23   |  | Amendment to Manufacturing and Supply Agreement, effective as of December 31, 2013, between Juniper Pharmaceuticals (Bermuda) Ltd., and Fleet Laboratories Limited (incorporated by reference to Exhibit 10.1 to the
Registrants Current Report on Form 8-K (File No. 001-10352), filed on February 6, 2014)                                          
|        | 
|10.24*  |  | Employment Agreement, dated September 23, 2014, by and between Juniper Pharmaceuticals, Inc. and George O. Elston (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on Form 8-K (File No. 001-10352), filed on September 26, 2014)                                                                                         
|        | 
|10.25   |  | Exclusive Patent License Agreement, dated as of March 27, 2015, by and between Juniper Pharmaceuticals, Inc. (f/k/a Columbia Laboratories, Inc.) and The General Hospital Corporation, d/b/a Massachusetts General Hospital
(incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q (File No. 001-10352), filed on May 6, 2015)
|        | 
|10.26   |  | Office Lease by and between T-C 33 Arch Street LLC and Juniper Pharmaceuticals, Inc. dated October 15, 2015 (incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q (File No. 001-10352), filed on
November 12, 2015)                                                                                                          
|        | 
|21      |  | Subsidiaries of the Company (incorporated by reference to Exhibit 21 to the Annual Report on Form 10-K (File No. 001-10352), filed on March 10, 2016)                                                                                                                                                                                                  
|        | 
|23.1    |  | Consent of BDO USA, LLP, Independent Registered Public Accounting Firm (incorporated by reference to Exhibit 23.1 to the Annual Report on Form 10-K (File No. 001-10352), filed on
March 10, 2016)                                                                                                                                                     
|        | 
|31(i).1 |  | Certification of Chief Executive Officer of the Company                                                                                                                                                                                                                                                                                                
|        | 
|31(i).2 |  | Certification of Chief Financial Officer of the Company                                                                                                                                                                                                                                                                                                
|        | 
|32.1    |  | Certification of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 32.1 to the Annual Report on Form 10-K (File No.
001-10352), filed on March 10, 2016)                                                                          
|        | 
|32.2    |  | Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 32.2 to the Annual Report on Form 10-K (File No.
001-10352), filed on March 10, 2016)                                                                          
|        | 
|101     |  | The following materials from the Juniper Pharmaceuticals, Inc. Annual Report on Form 10-K for the year ended December 31, 2015, formatted in XBRL (eXtensible Business Reporting Language): (i) Consolidated Balance Sheets at
December 31, 2015 and December 31, 2014, (ii) Consolidated                                                              



34



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##### Table of Contents

|        |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit |  | Index Description of Exhibit                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|        | 
|        |  | Statements of Operations for the years ended December 31, 2015, 2014 and 2013, (iii) Consolidated Statements of Comprehensive Income for the years ended December 31, 2015, 2014 and 2013, (iv) Consolidated Statements of
Shareholders Equity for the years ended December 31, 2015, 2014 and 2013, (v) Consolidated Statements of Cash Flows for the years ended December 31, 2015, 2014 and 2013, and (vi) Notes to Consolidated Financial Statements
(incorporated by reference to Exhibit 101 to the Annual Report on Form 10-K (File No. 001-10352), filed on March 10, 2016)



| | Confidential treatment has been requested with respect to certain portions of this exhibit. Omitted portions have been filed separately with the SEC.
|- | -----------------------------------------------------------------------------------------------------------------------------------------------------

|* | Management contract or compensatory plans or arrangements
|- | ---------------------------------------------------------



35



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##### Table of Contents

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be
signed on its behalf by the undersigned, thereunto duly authorized.



|                     |  |                               |  |                                      
|-------------------- |  | ----------------------------- |  | -------------------------------------
|                     |  | JUNIPER PHARMACEUTICALS, INC.
|                     |  |                              
|Date: April 22, 2016 |  | By:                           |  | /s/ George O. Elston                 
|                     |  |                               |  | George O. Elston                     
|                     |  |                               |  | Chief Financial Officer and Treasurer



36



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##### Table of Contents

EXHIBIT INDEX



|        |  |                                                                                                                                                                                                                                                                                                                     
|------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit |  | Index Description of Exhibit                                                                                                                                                                                                                                                                                        
|        | 
|2.1     |  | Purchase and Collaboration Agreement, dated March 3, 2010, by and between Juniper Pharmaceuticals, Inc. and Coventry Acquisition, Inc. (incorporated by reference to Exhibit 2.1 to the Registrants Current Report on Form 8-K
(File No. 001-10352), filed on March 4, 2010)                                       
|        | 
|2.2     |  | Share Purchase Agreement, dated September 2013, between the Sellers, Juniper Pharmaceuticals, Inc. and Juniper Pharma Services Limited (incorporated by reference to Exhibit 2.1 to the Registrants Current Report on Form 8-K
(File No. 001-10352), filed on September 18, 2013)                                  
|        | 
|2.3     |  | Stock Purchase Agreement, dated March 6, 2014, by and between Juniper Pharmaceuticals, Inc. and Coventry Acquisition, Inc. (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on Form 8-K (File No.
001-10352), filed on March 7, 2014)                                                  
|        | 
|3.1     |  | Restated Certificate of Incorporation of the Company, as amended (incorporated by reference to Exhibit 3.1 to the Registrants Annual Report on Form 10-K (File No. 001-10352) for the year ended December 31, 2005, filed on
March 13, 2006)                                                                       
|        | 
|3.2     |  | Certificate of Amendment of Restated Certificate of Incorporation of the Company (incorporated by reference to Exhibit 3.1 to the Registrants Current Report on Form 8-K (File No. 001-10352), filed on July 6,
2010)                                                                                              
|        | 
|3.3     |  | Certificate of Amendment of Restated Certificate of Incorporation of the Company (incorporated by reference to Exhibit 3.1 to the Registrants Current Report on Form 8-K (File No. 001-10352), filed on August 8,
2013)                                                                                            
|        | 
|3.4     |  | Certificate of Amendment of Restated Certificate of Incorporation of the Company (incorporated by reference to Exhibit 3.1 to the Registrants Current Report on Form 8-K (File No. 001-10352), filed on April 3,
2015)                                                                                             
|        | 
|3.5     |  | Amended and Restated By-laws of Company (incorporated by reference to Exhibit 3.2 to the Registrants Current Report on Form 8-K (File No. 001-10352), filed on January 12, 2015)                                                                                                                                   
|        | 
|3.6     |  | Amendment No. 1 to the Amended and Restated By-laws of the Company (incorporated by reference to Exhibit 3.2 to the Registrants Current Report on Form 8-K (File No. 001-10352), filed on April 3, 2015)                                                                                                           
|        | 
|4.1     |  | Certificate of Designations, Preferences and Rights of Series C Convertible Preferred Stock of the Company, dated as of January 7, 1999 (incorporated by reference to Exhibit 4.1 to the Registrants Annual Report on Form 10-K
(File No. 001-10352) for the year ended December 31, 1998, filed on March 25, 1999)
|        | 
|4.2*    |  | Form of Option Agreement (incorporated by reference to Exhibit 4.10 to the Registrants Annual Report on Form 10-K (File No. 001-10352) for the year ended December 31, 2008, filed on March 16, 2009)                                                                                                              
|        | 
|4.3     |  | Amended and Restated Rights Agreement by and between Juniper Pharmaceuticals, Inc. and American Stock Transfer & Trust Company, LLC dated January 28, 2015 (incorporated by reference to Exhibit 4.1 to the Registrants
Current Report on Form 8-K (File No. 001-10352), filed on January 30, 2015)                
|        | 
|10.1*   |  | 1996 Long-term Performance Plan, as amended, of the Company (incorporated by reference to Annex A to the Registrants Proxy Statement (File No. 001-10352), filed on May 10, 2000)                                                                                                                                  
|        | 
|10.2*   |  | Form of Restricted Stock Agreement under the 1996 Long-Term Performance Plan (incorporated by reference to Exhibit 10.62 of the Registrants Current Report on Form 8-K (File No. 001-10352), filed on May 17, 2006)                                                                                                
|        | 
|10.3    |  | License Agreement, dated April 18, 2000, between the Company and Lil Drug Store Products, Inc. (incorporated by reference to Exhibit 10.23 to the Registrants Quarterly Report on Form 10-Q (File No. 001-10352) for the
quarter ended March 31, 2000, filed on May 15, 2000)                                     
|        | 
|10.4*   |  | Form of Indemnification Agreement for Officers and Directors (incorporated by reference to Exhibit 10.46 to the Registrants Annual Report on Form 10-K (File No. 001-10352) for the year ended December 31, 2003, filed on
March 15, 2004)                                                                         
|        | 
|10.5    |  | Packaging Agreement, dated October 28, 1993, between Juniper Pharmaceuticals (Ireland) Ltd. and Maropack AG (incorporated by reference to Exhibit 10.32 to the Registrants Annual Report on Form 10-K (File No. 001-10352) for the
year ended December 31, 2007, filed on March 28, 2008)                          



---

##### Table of Contents

|        |  |                                                                                                                                                                                                                                                                                                                                    
|------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit |  | Index Description of Exhibit                                                                                                                                                                                                                                                                                                       
|        | 
|10.6*   |  | Juniper Pharmaceuticals, Inc. Amended and Restated 2008 Long-Term Incentive Plan (incorporated by reference to Appendix B to the Registrants Proxy Statement (File No. 001-10352), filed on March 22, 2013)                                                                                                                       
|        | 
|10.7*   |  | Form of Award Agreement under the Amended and Restated 2008 Long-term Incentive Plan of Juniper Pharmaceuticals, Inc. (incorporated by reference to Exhibit 4.4 to the Registrants Registration Statement on Form S-8 (File No.
333-18647), filed on May 16, 2013)                                                                
|        | 
|10.8*   |  | Juniper Pharmaceuticals, Inc. 2015 Long-Term Incentive Plan (incorporated by reference to Exhibit 4.5 to the Registrants Registration Statement on Form S-8 (File No. 333-205723), filed on July 17, 2015)                                                                                                                        
|        | 
|10.9*   |  | Form of Nonqualified Stock Option Award Agreement under the Juniper Pharmaceuticals, Inc. 2015 Long-Term Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrants Quarterly Report on Form 10-Q (File No.
001-10352), filed on August 4, 2015)                                                                
|        | 
|10.10*  |  | Form of Incentive Stock Option Award Agreement under the Juniper Pharmaceuticals, Inc. 2015 Long-Term Incentive Plan (incorporated by reference to Exhibit 10.2 to the Registrants Quarterly Report on Form 10-Q (File No.
001-10352), filed on August 4, 2015)                                                                   
|        | 
|10.11*  |  | Form of Restricted Stock Award Agreement under the Juniper Pharmaceuticals, Inc. 2015 Long-Term Incentive Plan (incorporated by reference to Exhibit 10.3 to the Registrants Quarterly Report on Form 10-Q (File No. 001-10352),
filed on August 4, 2015)                                                                         
|        | 
|10.12*  |  | Form of Executive Change of Control Severance Agreement (incorporated by reference to Exhibit 10.25 to the Registrants Annual Report on Form 10-K (File No. 001-10352) for the year ended December 31, 2008, filed on March
16, 2009)                                                                                             
|        | 
|10.13   |  | Manufacturing and Supply Agreement, dated December 8, 2009, between Fleet Laboratories and Juniper Pharmaceuticals (Bermuda), Ltd. (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on Form 8-K
(File No. 001-10352), filed on December 9, 2009)                                                      
|        | 
|10.14   |  | Note Purchase and Amendment Agreement, dated March 3, 2010, by and between Juniper Pharmaceuticals, Inc. and holders listed on Schedule I thereto (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on
Form 8-K (File No. 001-10352), filed on March 4, 2010)                                          
|        | 
|10.15*  |  | Amended and Restated Employment Agreement, dated May 4, 2010, by and between Juniper Pharmaceuticals, Inc. and Frank C. Condella, Jr. (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on Form 8-K
(File No. 001-10352), filed on May 5, 2010)                                                        
|        | 
|10.16*  |  | Addendum to Amended and Restated Employment Agreement, dated March 1, 2011, by and between Juniper Pharmaceuticals, Inc., and Frank C. Condella, Jr. (incorporated by reference to Exhibit 10.46 to the Registrants Annual Report
on Form 10-K (File No. 001-10352) for the year ended December 31, 2010, filed on March 10, 2011)
|        | 
|10.17   |  | Second Amended and Restated License and Supply Agreement, dated May 14, 2010, between Juniper Pharmaceuticals, Inc. and Ares Trading S.A. (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on Form 8-K
(File No. 001-10352), filed on May 18, 2010)                                                   
|        | 
|10.18   |  | Amendment No. 1 to the Second Amended and Restated License and Supply Agreement, dated April 4, 2013, between Juniper Pharmaceuticals, Inc. and Ares Trading S.A. (incorporated by reference to Exhibit 10.1 to the
Registrants Current Report on Form 8-K (File No. 001-10352), filed on April 9, 2013)                          
|        | 
|10.19   |  | Parent Guarantee of Juniper Pharmaceuticals, Inc., dated September 12, 2013 (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on Form 8-K (File No. 001-10352), filed on September 18, 2013)                                                                                                           
|        | 
|10.20*  |  | Employment Agreement, dated September 12, 2013, between Dr. Nikin Patel and Juniper Pharmaceuticals, Inc. (incorporated by reference to Exhibit 10.2 to the Registrants Current Report on Form 8-K (File No. 001-10352),
filed on September 18, 2013)                                                                             
|        | 
|10.21   |  | Bank Loan Agreement, dated January 6, 2012, between Juniper Pharma Services Limited and Lloyds TSB Bank plc (incorporated by reference to Exhibit 10.3 the Registrants Quarterly Report on Form 10-Q (File No. 001-10352) for
the quarter ended September 30, 2013, filed on November 7, 2013)                                    
|        | 
|10.22   |  | Amendment letter, dated September 16, 2013, between Juniper Pharma Services Limited and Lloyds TSB Bank plc (incorporated by reference to Exhibit 10.4 the Registrants Quarterly Report on Form 10-Q (File No. 001-10352) for the
quarter ended September 30, 2013, filed on November 7, 2013)                                    



---

##### Table of Contents

|        |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
|------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit |  | Index Description of Exhibit                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
|        | 
|10.23   |  | Amendment to Manufacturing and Supply Agreement, effective as of December 31, 2013, between Juniper Pharmaceuticals (Bermuda) Ltd., and Fleet Laboratories Limited (incorporated by reference to Exhibit 10.1 to the Registrants
Current Report on Form 8-K (File No. 001-10352), filed on February 6, 2014)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
|        | 
|10.24*  |  | Employment Agreement, dated September 23, 2014, by and between Juniper Pharmaceuticals, Inc. and George O. Elston (incorporated by reference to Exhibit 10.1 to the Registrants Current Report on Form 8-K (File No. 001-10352),
filed on September 26, 2014)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
|        | 
|10.25   |  | Exclusive Patent License Agreement, dated as of March 27, 2015, by and between Juniper Pharmaceuticals, Inc. (f/k/a Columbia Laboratories, Inc.) and The General Hospital Corporation, d/b/a Massachusetts General Hospital
(incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q (File No. 001-10352), filed on May 6, 2015)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
|        | 
|10.26   |  | Office Lease by and between T-C 33 Arch Street LLC and Juniper Pharmaceuticals, Inc. dated October 15, 2015 (incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q (File No. 001-10352), filed on November 12,
2015)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
|        | 
|21      |  | Subsidiaries of the Company (incorporated by reference to Exhibit 21 to the Annual Report on Form 10-K (File No. 001-10352), filed on March 10, 2016)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
|        | 
|23.1    |  | Consent of BDO USA, LLP, Independent Registered Public Accounting Firm (incorporated by reference to Exhibit 23.1 to the Annual Report on Form 10-K (File No. 001-10352), filed on March 10, 2016)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
|        | 
|31(i).1 |  | Certification of Chief Executive Officer of the Company                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
|        | 
|31(i).2 |  | Certification of Chief Financial Officer of the Company                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
|        | 
|32.1    |  | Certification of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 32.1 to the Annual Report on Form 10-K (File No.
001-10352), filed on March 10, 2016)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
|        | 
|32.2    |  | Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit 32.2 to the Annual Report on Form 10-K (File No.
001-10352), filed on March 10, 2016)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
|        | 
|101     |  | The following materials from the Juniper Pharmaceuticals, Inc. Annual Report on Form 10-K for the year ended December 31, 2015, formatted in XBRL (eXtensible Business Reporting Language): (i) Consolidated Balance Sheets at December
31, 2015 and December 31, 2014, (ii) Consolidated Statements of Operations for the years ended December 31, 2015, 2014 and 2013, (iii) Consolidated Statements of Comprehensive Income for the years ended December 31, 2015, 2014 and 2013, (iv)
Consolidated Statements of Shareholders Equity for the years ended December 31, 2015, 2014 and 2013, (v) Consolidated Statements of Cash Flows for the years ended December 31, 2015, 2014 and 2013, and (vi) Notes to Consolidated Financial
Statements (incorporated by reference to Exhibit 101 to the Annual Report on Form 10-K (File No. 001-10352), filed on March 10, 2016)



| | Confidential treatment has been requested with respect to certain portions of this exhibit. Omitted portions have been filed separately with the SEC.
|- | -----------------------------------------------------------------------------------------------------------------------------------------------------

|* | Management contract or compensatory plans or arrangements
|- | ---------------------------------------------------------