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                    U.S. DEPARTMENT OF AGRICULTURE
 Endemic Poultry Viral Diseases Research: Athens, GA
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                        Richard B Russell Center
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ARS Home Southeast Area Athens, Georgia U.S. National Poultry Research Center Endemic Poultry Viral Diseases Research People & Locations







Cari  Hearn
                        Endemic Poultry Viral Diseases Research

                        




                        
                        Veterinary Medical Officer
                        Phone: (269) 325-1023
                        
                        
                        Fax: (Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            ProjectsInfluence of Vaccines, Host Genetics and Pathogen Mutation Rates on the Evolutionary Dynamics of Infectious Diseases - Purdue
                                                    Cooperative Agreement
                                                                    (A)Accession Number: 439583Elucidation of Molecular Determinants of Avian Herpesviruses Virulence and Evolution to Inform the Development of Safe and Effective Vaccines
                                                    In-House Appropriated
                                                                    (D)Accession Number: 441124Enhancing Genetic Resistance and Vaccinal Response to Control Marek's Disease, Infectious Laryngotracheitis, and Infectious Bursal Disease in Chicken
                                                    In-House Appropriated
                                                                    (D)Accession Number: 443180Influence of Vaccines, Host Genetics, and Pathogen Mutation Rates on the Evolutionary Dynamics of Infectious Diseases - Berlin
                                                    Non-Assistance Cooperative Agreement
                                                                    (S)Accession Number: 439572**Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)Efficacy of recombinant Marek’s disease vaccine 301B/1 expressing membrane-anchored chicken interleukin-15

- (Peer Reviewed Journal)Phenotypic characterization of recombinant Marek’s disease virus in live birds validates polymorphisms associated with virulence
                                                        

- (Peer Reviewed Journal)Kim, T.N., Hearn, C.J., Mays, J.K., Velez-Irizarry, D., Reddy, S.M., Spatz, S.J., Cheng, H.H., Dunn, J.R. 2023. Phenotypic characterization of recombinant Marek’s disease virus in live birds validates polymorphisms associated with virulence. Viruses. 15(11):2263. https://doi.org/10.3390/v15112263.A pangenome graph reference of 30 chicken genomes allows genotyping of large and complex structural variants
                                                        

- (Peer Reviewed Journal)Rice, E.S., Alberdi, A., Alfieri, J., Athery, G., Balacco, J.R., Bardou, P., Blackmon, H., Charles, M., Cheng, H.H., Fedrigo, O., Fiddaman, S., Formenti, G., Frantz, L., M. Thomas, G.P., Hearn, C.J., Jarvis, E.D., Klopp, C., Marcos, S., Velez-Irizarry, D., Xu, L., Warren, W.C., Mason, A.S. 2023. A pangenome graph reference of 30 chicken genomes allows genotyping of large and complex structural variants. BMC Biology. 21(267). https://doi.org/10.1186/s12915-023-01758-0.The immune cell landscape and response of Marek's disease resistant and susceptible chickens infected with Marek's disease virus
                                                        

- (Peer Reviewed Journal)Warren, W.C., Rice, E.S., Meyer, A., Hearn, C.J., Steep, A., Hunt, H.D., Monson, M.S., Lamont, S.J., Cheng, H.H. 2023. The immune cell landscape and response of Marek's disease resistant and susceptible chickens infected with Marek's disease virus. Scientific Reports. 13. Article 5355. https://doi.org/10.1038/s41598-023-32308-x.Contribution of the TCR beta repertoire to Marek's disease genetic resistance in chicken
                                                        

- (Peer Reviewed Journal)Hearn, C.J., Cheng, H.H. 2023. Contribution of the TCR beta repertoire to Marek's disease genetic resistance in chicken. Viruses. 15(3):607. https://doi.org/10.3390/v15030607.Progress toward an immune cell atlas in the chicken

- (Abstract Only)Targeted ablation of exon 2 of the Avian Leukosis Virus-A (ALV-A)receptor gene in a chicken fibroblast cell line by CRISPR abrogates ALV-A infection
                                                        

- (Peer Reviewed Journal)Conrad, S.J., Mays, J.K., Hearn, C.J., Dunn, J.R. 2023. Targeted ablation of exon 2 of the Avian Leukosis Virus-A (ALV-A)receptor gene in a chicken fibroblast cell line by CRISPR abrogates ALV-A infection. Avian Diseases. 67(1):102-107. https://doi.org/10.1637/aviandiseases-D-22-00072.Fast forwarding evolution – accelerated adaptation in a proofreading deficient hypermutator herpesvirus
                                                        

- (Peer Reviewed Journal)Xing, N., Hofler, T., Hearn, C.J., Nascimento, M., Camps Paradell, G., Mcmahon, D.P., Kunec, D., Cheng, H.H., Trimpert, J., Osterrieder, N. 2022. Fast forwarding evolution – accelerated adaptation in a proofreading deficient hypermutator herpesvirus. Virus Evolution. 8(2):veac099. https://doi.org/10.1093/ve/veac099.Identification and validation of Ikaros (IKZF1) as a cancer driver gene for Marek’s disease virus-induced lymphomas
                                                        

- (Peer Reviewed Journal)Steep, A., Hildebrandt, E.C., Xu, H., Hearn, C.J., Frishman, D., Niikura, M., Dunn, J.R., Kim, T.N., Conrad, S.J., Muir, W.M., Cheng, H.H. 2022. Identification and validation of Ikaros (IKZF1) as a cancer driver gene for Marek’s disease virus-induced lymphomas. Microorganisms. 10(2):401. https://doi.org/10.3390/microorganisms10020401.Vaccinal efficacy of recombinant Marek’s disease vaccine 301B/1 expressing chicken interleukin-15
                                                        

- (Peer Reviewed Journal)Kim, T.N., Hearn, C.J. 2022. Vaccinal efficacy of recombinant Marek’s disease vaccine 301B/1 expressing chicken interleukin-15. Avian Diseases. 66(1):79-84. https://doi.org/10.1637/21-00089.B cells do not play a role in vaccine-mediated immunity against Marek's disease
                                                        

- (Peer Reviewed Journal)Heidari, M., Zhang, H., Hearn, C.J., Sunkara, L. 2021. B cells do not play a role in vaccine-mediated immunity against Marek's disease. Vaccine. 10:100128. https://doi.org/10.1016/j.jvacx.2021.100128.Comparison of Marek's disease virus challenge strains and bird types for vaccine licensing
                                                        

- (Peer Reviewed Journal)Dunn, J.R., Mays, J.K., Hearn, C.J., Hartman, A. 2021. Comparison of Marek's disease virus challenge strains and bird types for vaccine licensing. Avian Diseases. 65(2):241-249. https://doi.org/10.1637/aviandiseases-D-20-00122.Immune-tolerance mediated neuropathogenicity of Marek's disease vaccines

- (Abstract Only)The Secretion of Type I Interferons as a Primary Determinant of Susceptibility to Marek’s Disease Virus in Chickens

- (Abstract Only)Codon deoptimization of UL54 in meq-deleted Marek's disease vaccine candidate eliminates lymphoid atrophy but reduces vaccinal protection
                                                        

- (Peer Reviewed Journal)Conrad, S.J., Hearn, C.J., Silva, R.F., Dunn, J.R. 2020. Codon deoptimization of UL54 in meq-deleted Marek's disease vaccine candidate eliminates lymphoid atrophy but reduces vaccinal protection. Avian Diseases. 64(3):243-246. https://doi.org/10.1637/aviandiseases-D-19-00166.Role of the Chicken T Cell Receptor-Beta Repertoire in Genetic Resistance to Marek's Disease

- (Abstract Only)Attenuation of Marek’s disease virus by codon pair deoptimization of core herpesvirus genes
                                                        

- (Peer Reviewed Journal)Conrad, S.J., Silva, R.F., Hearn, C.J., Climans, M., Dunn, J.R. 2018. Attenuation of Marek’s disease virus by codon pair deoptimization of core herpesvirus genes. Virology. 516:219-226. https://doi.org/10.1016/j.virol.2018.01.020.Differential TCR Vbeta Usage in the Peripheral T Cells of Chickens Resistant and Susceptible to Marek’s Disease

- (Abstract Only)Expression of Marek's disease virus oncoprotein Meq during infection in the natural host
                                                        

- (Peer Reviewed Journal)Tai, S., Hearn, C.J., Umthong, S., Agafitei, O., Cheng, H.H., Dunn, J.R., Niikura, M. 2017. Expression of Marek's disease virus oncoprotein Meq during infection in the natural host. Virology. 503:103-113. doi:10.1016/j.virol.2017.01.011.


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