EXHIBIT 10.14

                        AMENDMENT TO EMPLOYMENT AGREEMENT

        This amendment dated as of October 8, 1998 (the "EFFECTIVE DATE"),
between COLUMBIA LABORATORIES, INC., a Delaware corporation and any successor
thereof (the "COMPANY"), and NICHOLAS A. BUONICONTI ("EMPLOYEE"). Capitalized
terms not otherwise defined herein shall have the meanings ascribed to them in
the employment agreement between Employee and the Company dated as of April 15,
1997, as amended by the addendum dated as of September 1, 1997 (the "EMPLOYMENT
AGREEMENT").

                              W I T N E S S E T H :

        WHEREAS, the Company is and will be engaged in the development, testing,
registration, manufacturing, licensing, marketing, and selling of pharmaceutical
products;

        WHEREAS, Employee and the Company are parties to the Employment
Agreement relating to the terms and conditions of Employee's services as an
employee and officer of the Company;

        WHEREAS, the Company and Employee desire to enter into this amendment
(the "AMENDMENT") to the Employment Agreement; and

        WHEREAS, the terms of the Employment Agreement shall be modified only by
the specific terms and conditions set forth herein, which shall either add
additional terms to the Employment Agreement or modify and supercede the
provisions in the Employment Agreement that address the subject matter hereof
and, in the event of any inconsistency between this Amendment and the Employment
Agreement, the provisions of this Amendment shall govern;

        NOW, THEREFORE, in consideration of the premises and the mutual
covenants herein contained, the parties hereto agree as follows:

         1.       EMPLOYMENT; DUTIES. The Company shall employ Employee and
                  Employee hereby agrees to be employed by the Company for the
                  remainder of the Term; provided, however, that as of the
                  Executive Date, Employee hereby resigns from his positions as
                  Chief Operating Officer and Vice Chairman. His duties shall be
                  as directed by the Board of Directors or its designee.
                  Employee shall not be required to provide his services to the
                  Company on a substantially full-time basis, as set forth in
                  Section 5(b) of the Employment Agreement; instead, Employee
                  shall devote approximately five hours per month to his duties
                  to the Company, as requested by the Company.

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         2.       COMPENSATION. The Company shall continue to pay Employee his
                  base salary at the annual rate of $300,000 per year during the
                  period commencing on the day following the Effective Date and
                  ending on December 31, 1998. Such salary payments shall be
                  paid in accordance with the Company's payroll practices
                  commencing on the next payroll date following the Effective
                  Date, in an amount equal to the amount paid to Employee by the
                  Company for the payroll period immediately prior to the
                  Effective Date. For the remainder of the Term after December
                  31, 1998, the Company shall pay Employee a salary of $500 per
                  month.

         3.       FRINGE BENEFITS. Through December 31, 1998 Employee shall
                  continue to be given an automobile allowance or automobile
                  lease plan to the extent provided him immediately before the
                  Effective Date.

         4.       STOCK OPTIONS. The Company and Employee are parties to option
                  agreements (the "OPTION AGREEMENTS") in connection with the
                  Company's 1988 Stock Option Plan, as amended (the "1988
                  PLAN"), and the Company's 1996 Long-Term Performance Plan (the
                  "1996 PLAN" and, together with the 1988 Plan, the "PLANS").
                  Pursuant to the Option Agreements, the Company has granted
                  Employee stock options (the "STOCK OPTIONS") to purchase up to
                  a maximum of 1,360,000 shares of common stock of the Company
                  in accordance with the terms and provisions of the Option
                  Agreements and the Plans.

                  (A) 1988 PLAN. The Company and Employee acknowledge that,
                      as of the Effective Date, all of the 960,000 Stock
                      Options granted pursuant to the 1988 Plan are vested.
                      All Stock Options granted thereunder shall remain
                      exercisable for a period of two and one-half years
                      after the end of the Term.

                  (B) 1996 PLAN. The Company and Employee acknowledge that of

                      the 400,000 Stock Options granted pursuant to the
                      1996 Plan, 287,500 are vested as of the Effective
                      Date. To the extent that on or prior to the tenth day
                      following the Effective Date (the "OPTION
                      CANCELLATION DATE") Employee exercises any Stock
                      Options under the Plans, an equal number of Stock
                      Options that are unvested on the date of such
                      exercise shall immediately vest on a one-for-one
                      basis in the order such options would otherwise vest.
                      Any options under the 1996 Plan which have not vested
                      on or prior to the Option Cancellation Date shall be
                      canceled on such date and be of no further force or
                      effect. The Company and Employee acknowledge that as
                      set forth in the respective Option Agreements issued
                      to Employee pursuant to the 1996 Plan, already vested
                      Stock Options granted under the 1996 Plan shall
                      remain exercisable by Employee until they expire on
                      the tenth anniversary of their respective dates of grant.

         5.       TERMINATION OF EMPLOYMENT WITHOUT CAUSE. During the Term, the
                  Company may not terminate the employment of Employee other
                  than for Cause.

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         6.       INDEMNIFICATION. The Company acknowledges that Employee is
                  entitled to and shall be afforded indemnification in
                  connection with, relating to, or arising about of his service
                  as an officer or director of the Company or any other aspect
                  of his employment with or services for the Company to the
                  fullest extent that such indemnification is provided to
                  officers or directors of the Company.

         7.       COMMENT.

                  (A) BY THE COMPANY. The Company shall refrain from making now
                      or at any time in the future any false or defamatory
                      comment, statement or other communication concerning
                      Employee or Employee's employment relationship with
                      the Company to any third party, including, without
                      limitation, the press, any employee of the Company
                      and any individual or entity with whom Employee or
                      the Company has a current or prospective business
                      relationship.

                  (B) BY THE EMPLOYEE. Employee shall refrain from making now
                       or at any time in the future any false or defamatory
                       comment, statement or other communication concerning
                       the Company, its products, its services or any
                       current or former directors, officers or employees of
                       the Company to any third party, including, without
                       limitation, the press, any employee of the Company
                       and any individual or entity with whom Employee or
                       the Company has a current or prospective business
                       relationship.

         8.       PRESS RELEASE. On or immediately following the Effective Date
                  the Company shall issue a press release regarding the
                  modification of Employee's positions with and duties to the
                  Company in the form attached hereto as Exhibit A.

         9.       ATTORNEY'S FEES AND COSTS. The Company shall promptly pay
                  Employee's attorneys' fees and related costs in the amount of
                  $20,000 incurred in connection with the negotiation, drafting
                  and execution of this Amendment.

         10.      BINDING AGREEMENT; SUCCESSORS. This Amendment and the
                  Employment Agreement shall be binding upon, and inure to the
                  benefit of, the parties hereto, any successors to or assigns
                  of the Company and Employee's heirs and the personal
                  representatives of Employee's estate.

         11.      COUNTERPARTS. This Amendment may be executed by the parties
                  hereto in counterparts, each of which shall be deemed to be an
                  original, but all such counterparts shall together constitute
                  one and the same instrument.

         12.      HEADINGS. The headings of sections herein are included solely
                  for convenience of reference and shall not control the meaning
                  or interpretation of any of the provisions of this Amendment.

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           IN WITNESS WHEREOF, the Company has caused this Amendment to be
           signed by its officer pursuant to the authority of its Board of
           Directors, and Employee has executed this Amendment as of the day and
           year first written above.

                                            COLUMBIA LABORATORIES, INC.

                                            By:
                                                   ---------------------------
                                                   William J. Bologna
                                                   Chairman of the Board

AGREED AND ACCEPTED:


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Nicholas A. Buoniconti