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 Animal Biosciences & Biotechnology Laboratory: Beltsville, MD
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ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Animal Biosciences & Biotechnology Laboratory People & Locations







Charles  Li
                        Animal Biosciences & Biotechnology Laboratory

                        




                        
                        Veterinary Medical Officer
                        Phone: (301) 504-8187
                        
                        
                        Fax: (Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            ProjectsAlternatives to Antibiotics Strategies to Control Enteric Diseases of Poultry
                                                    In-House Appropriated
                                                                    (D)Accession Number: 441270**Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)Editorial; immunosuppressive diseases in poultry
                                                        

- (Peer Reviewed Journal)Li, C.Z., Wang, L., Zhang, S. 2023. Editorial; immunosuppressive diseases in poultry. Frontiers in Immunology. 14:1215513. https://doi.org/10.3389/fimmu.2023.1215513.Characterization of collagen binding capability of clostridium perfringens isolate collections from broiler chickens
                                                        

- (Peer Reviewed Journal)Sun, Z., Lu, M., Lillehoj, H.S., Lee, Y., Doo, D., Yuan, B., Yan, X., Li, C.Z. 2023. Characterization of collagen binding capability of clostridium perfringens isolate collections from broiler chickens . Pathogens. 12:778. https://doi.org/10.3390/pathogens12060778.Collagen adhesin protein and necrotic enteritis B-like toxin as biomarkers for early diagnosis of necrotic enteritis in commercial broiler chickens
                                                        

- (Peer Reviewed Journal)Goo, D., Park, I., Nam, H., Lee, Y., Sawall, J., Smith, X., Li, C.Z., Lillehoj, H.S. 2023. Collagen adhesin protein and necrotic enteritis B-like toxin as biomarkers for early diagnosis of necrotic enteritis in commercial broiler chickens. Poultry Science. https://doi.org/10.1016/j.psj.2023.102647.Immunization with pooled antigens for Clostridium perfringens conferred partial protection against experimental necrotic enteritis in broiler chickens
                                                        

- (Peer Reviewed Journal)Yuan, B., Sun, Z., Lu, M., Lillehoj, H.S., Lee, Y., Liu, L., Yan, X., Li, C.Z. 2022. Immunization with pooled antigens for Clostridium perfringens conferred partial protection against experimental necrotic enteritis in broiler chickens. Vaccines. 10(6):979. https://doi.org/10.3390/vaccines10060979.Immunological characterization of chicken tumor necrosis factor-a (TNF-a) using new sets of monoclonal antibodies specific for poultry TNF
                                                        

- (Peer Reviewed Journal)Lu, M., Lee, Y., Li, C.Z., Lillehoj, H.S. 2022. Immunological characterization of chicken tumor necrosis factor-a (TNF-a) using new sets of monoclonal antibodies specific for poultry TNF. Developmental and Comparative Immunology. https://doi.org/10.1016/j.dci.2022.104374.Immunization with recombinant haemonchus contortus Y75B8A.8 partially protects local crossbred female goats from haemonchus contortus infection
                                                        

- (Peer Reviewed Journal)Tian, X., Lu, M., Bu, Y., Zhang, Y., Aimulajiang, K., Liang, M., Li, C.Z., Yan, R., Xu, L., Song, X., Li, X. 2022. Immunization with recombinant haemonchus contortus Y75B8A.8 partially protects local crossbred female goats from haemonchus contortus infection. Frontiers in Veterinary Science. 9:765700. https://doi.org/10.3389/fvets.2022.765700.Clostridium perfringens-induced host-pathogen transcriptional changes in the small intestine of broiler chickens
                                                        

- (Peer Reviewed Journal)Qu, G., Xu, Z., Tuo, W., Li, C.Z., Wan, G., Lillehoj, H.S., Gong, H., Huang, J., Tian, G., Li, S., Liu, Y., Liu, L. 2021. Clostridium perfringens-induced host-pathogen transcriptional changes in the small intestine of broiler chickens. Frontiers in Veterinary Science. https://doi.org/10.1016/j.vetpar.2021.109642.Clostridium perfringens-Induced Host-Pathogen Transcriptional Changes in the Small Intestine of Broiler Chickens
                                                        

- (Peer Reviewed Journal)Lu, M., Yuan, B., Yan, X., Sun, Z., Lillehoj, H.S., Lee, Y., Li, C.Z. 2021. Clostridium perfringens-Induced Host-Pathogen Transcriptional Changes in the Small Intestine of Broiler Chickens. Pathogens. 10(12):1607. https://doi.org/10.3390/pathogens10121607.Comparison of the pathogenicity of five clostridium perfringens isolates using an eimeria maxima coinfection necrotic enteritis disease model in commercial broiler chickens
                                                        

- (Peer Reviewed Journal)Liu, L., Yan, X., Lillehoj, H.S., Sun, Z., Zhao, H., Xianyu, Z., Lee, Y., Melville, S., Gu, C., Li, C.Z. 2021. Comparison of the pathogenicity of five clostridium perfringens isolates using an eimeria maxima coinfection necrotic enteritis disease model in commercial broiler chickens. Avian Diseases. https://doi.org/10.1637/aviandiseases-D-19-00098.First report on detection of necrotic enteritis (NE) B-like toxin in biological samples from NE-afflicted chickens by capture enzyme-linked immunosorbent assay
                                                        

- (Peer Reviewed Journal)Lee, K., Lillehoj, H.S., Kim, W., Park, I., Li, C.Z., Lu, M., Hofacre, C.L. 2021. First report on detection of necrotic enteritis (NE) B-like toxin in biological samples from NE-afflicted chickens by capture enzyme-linked immunosorbent assay. Poultry Science. https://doi.org/10.1016/j.psj.2021.101190.Development and characterization of novel mouse monoclonal antibodies against chicken chemokine CC motif ligand 4
                                                        

- (Peer Reviewed Journal)Lu, M., Kim, W., Lillehoj, H.S., Li, C.Z. 2020. Development and characterization of novel mouse monoclonal antibodies against chicken chemokine CC motif ligand 4. Veterinary Immunology and Immunopathology. https://doi.org/10.1016/j.vetimm.2020.110091.Identification of enterobacteria in viscera of pigs afflicted with porcine reproductive and respiratory syndrome and other viral co-infections

- (Peer Reviewed Journal)Zhao, G., Zhang, L., Li, C.Z., Zhao, J., Liu, N., Li, Y., Wang, J., Liu, L. 2020. Identification of enterobacteria in viscera of pigs afflicted with porcine reproductive and respiratory syndrome and other viral co-infections. Microbial Pathogenesis. 147:10385.Detection of Necrotic Enteritis B-like toxin secreted by Clostridium perfringens using capture Enzyme-Linked Immunosorbent Assay
                                                        

- (Peer Reviewed Journal)Lee, K., Kim, W., Li, C.Z., Lillehoj, H.S. 2020. Detection of Necrotic Enteritis B-like toxin secreted by Clostridium perfringens using capture Enzyme-Linked Immunosorbent Assay. Avian Diseases. 64(4):490-495. https://doi.org/10.1637/0005-2086-64.4.490.A novel a/ß hydrolase domain protein derived from Haemonchus Contortus acts at the parasite-host interface
                                                        

- (Peer Reviewed Journal)Lu, M., Tian, X., Tian, A., Li, C.Z., Yan, R., Xu, L., Song, X., Li, X. 2020. A novel a/ß hydrolase domain protein derived from Haemonchus Contortus acts at the parasite-host interface. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2020.01388.Unveiling the immunomodulatory properties of Haemonchus contortus adhesion regulating molecule 1 in the parasite-host interactions
                                                        

- (Peer Reviewed Journal)Lu, M., Tian, X., Zhang, Y., Aimulajiang, K., Wang, W., Ehsan, M., Li, C.Z., Yan, R., Xu, L., Lu, X. 2020. Unveiling the immunomodulatory properties of Haemonchus contortus adhesion regulating molecule 1 in the parasite-host interactions. Parasites & Vectors. https://doi.org/10.1186/s13071-020-04297-7.Effects of Eimeria maxima and Clostridium perfringens infections on cecal microbiome components and correlation with body weight in broiler chickens
                                                        

- (Peer Reviewed Journal)Lu, M., Li, R., Zhao, H., Yan, X., Lillehoj, H.S., Sun, Z., Oh, S., Wang, Y., Li, C.Z. 2020. Effects of Eimeria maxima and Clostridium perfringens infections on cecal microbiome components and correlation with body weight in broiler chickens. Research in Veterinary Science. https://doi.org/10.1016/j.rvsc.2020.05.013.Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins
                                                        

- (Peer Reviewed Journal)Lu, M., Tian, X., Yang, Z., Wang, W., Tian, A., Li, C.Z., Yan, R., Xu, L., Song, X., Li, X. 2020. Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins. Veterinary Research. https://doi.org/10.1186/s13567-020-00790-0.Immunization with a subunit of housekeeping proteins provide partial protection against experimental necrotic enteritis in broiler chickens

- (Abstract Only)Putting antimicrobial resistance in the corner
                                                        

- (Review Article)Li, C.Z., Lu, M. 2020. Putting antimicrobial resistance in the corner. Nature Food. https://doi.org/10.1038/s43016-020-0034-9.Haemonchus contortus transthyretin domain - containing protein (HcTTR): A promising vaccine candidate against Haemonchus contortus infection
                                                        

- (Peer Reviewed Journal)Tian, X., Lu, M., Jia, C., Bu, Y., Aimulajiang, K., Zhang, Y., Li, C.Z., Yan, R., Xu, L., Li, X. 2020. Haemonchus contortus transthyretin domain - containing protein (HcTTR): A promising vaccine candidate against Haemonchus contortus infection. Veterinary Parasitology. https://doi.org/10.1016/j.vetpar.2020.109045."Detection of necrotic enteritis (NE) B-like toxin in biological samples of NE-afflicted chickens by capture Enzyme-Linked Immunosorbent Assay"

- (Abstract Only)"Development and characterization of novel mouse monoclonal antibodies against chicken chemokine CC motif ligand 4"

- (Abstract Only)Immunization with subunits of important virulence factors produced by virulent Clostridium perfringens strains conferred partial protection against necrotic enteritis in broiler chickens

- (Abstract Only)Submission of genome sequences of Clostridium perfringens strain LLY_Tpel17  into genBank database

- (Database / Dataset)Eimeria maxima-induced transcriptional changes in the chicken intestine
                                                        

- (Peer Reviewed Journal)Li, C.Z., Yan, X., Lillehoj, H.S., Gu, C., Sun, Z., Oh, S., Lee, Y., Xianyu, Z., Zhao, H., Liu, L. 2019. Eimeria maxima-induced transcriptional changes in the chicken intestine. Frontiers in Immunology. 12:285. https://doi.org/10.1186/s13071-019-3534-4.Eimeria maxima-induced transcriptional changes in the cecal mucosa of broiler chickens
                                                        

- (Peer Reviewed Journal)Li, C.Z., Yan, X., Lillehoj, H.S., Gu, C., Sun, Z., Oh, S., Lee, Y., Xianyu, Z., Zhao, H., Liu, L. 2019. Eimeria maxima-induced transcriptional changes in the cecal mucosa of broiler chickens. Parasites & Vectors. https://doi.org/10.1186/s13071-019-3534-4.Development of poultry-specific immune reagents

- (Abstract Only)The transcriptional changes in chicken intestines in response to C. perfringens infection

- (Abstract Only)Expression and characterization of chicken perforin and granzyme a

- (Abstract Only)Development of poultry immune reagent

- (Abstract Only)Comparison of pathogenicity of several Clostridium perfringens strains with Eimeria maxima co-infection in inducing necrotic enteritis lesions in broiler chickens

- (Abstract Only)Li, C.Z., Liu, L., Yan, X., Lillehoj, H.S., Sun, Z., Zhao, H., Xianyu, Z., Lee, Y. 2018. Comparison of pathogenicity of several Clostridium perfringens strains with Eimeria maxima co-infection in inducing necrotic enteritis lesions in broiler chickens. Meeting Abstract. P19.Characterization of clostridium perfringens netB+tpel+ type A atrains isolated from necrotic enteritis-afflicted broiler chickens

- (Other)Li, C.Z., Lillehoj, H.S., Yan, X., Gu, C., Sun, Z., Lee, Y., Zhao, H., Xianyu, Z., Siragusa, G.R., Grant, A. 2018. Characterization of clostridium perfringens netB+tpel+ type A atrains isolated from necrotic enteritis-afflicted broiler chickens. Meeting Abstract. P52.Growth hormone receptor mutations related to individual dwarfism
                                                        

- (Review Article)Lin, S., Li, C., Li, C.Z., Zhang, X. 2018. Growth hormone receptor mutations related to individual dwarfism. International Journal of Molecular Sciences. 19(5):1433. https://doi.org/10.3390/ijms19051433.Development and characterization of chicken CD127-cpecific antibodies

- (Abstract Only)Immunoproteomic analysis of proteins from unsporulated Oocysts of Eimeria tenella in MALDI TOF/TOF tandem mass spectrometry

- (Peer Reviewed Journal)Li, C.Z., Liu, L., Zhenchao, Z., Shuai, W. 2017. Immunoproteomic analysis of proteins from unsporulated Oocysts of Eimeria tenella in MALDI TOF/TOF tandem mass spectrometry. Parasite. 24:48.Complete genome sequences of slostridium perfringens strain del1 isolated from necrotic enteritis-afflicted chicken farm
                                                        

- (Peer Reviewed Journal)Li, C.Z., Yan, X., Lillehoj, H.S. 2018. Complete genome sequences of slostridium perfringens strain del1 isolated from necrotic enteritis-afflicted chicken farm. Gut Pathogens. 9:69. https://doi.org/10.1186/s13099-017-0217-6.Effects of Eimeria maxima and Clostridium perfringens infections on Cecal Microbiome in Broiler Chickens Analyzed by 16S rRNA Sequencing

- (Abstract Only)Intestinal meta-transcriptome comparison reveals disparate antiviral transcriptional response and its association with Mitochondria in chicken immunity development

- (Abstract Only)Comparative genomic analysis of full genome sequences of two closely related isolates of Clostridium perfringens reveals regions of genome plasticity with prevention potential

- (Other)Characterization of Clostridium perfringens strains isolated from clinically healthy and necrotic enteritis-afflicted broiler chickens

- (Peer Reviewed Journal)Li, C.Z., Lillehoj, H.S., Gadde, U.D., Oh, S., Ritter, D. 2017. Characterization of Clostridium perfringens strains isolated from clinically healthy and necrotic enteritis-afflicted broiler chickens. Avian Diseases. 61:179-186.Draft genome sequences of clostridium perfringens strain LLY_N11, a pathogenic isolate of necrotic enteritis from a healthy chicken
                                                        

- (Peer Reviewed Journal)Li, C.Z., Yan, X., Lillehoj, H.S. 2017. Draft genome sequences of clostridium perfringens strain LLY_N11, a pathogenic isolate of necrotic enteritis from a healthy chicken. Genome Announcements. 5:44. https://doi.org/10.1128/genomeA.01225-17.Clostridium perfringens, necrotic enteritis and its vaccination in broiler chickens

- (Abstract Only)Characterization of virulent netB+/tpeI+ clostridium perfringens strains from necrotic-enteritis-affected broiler chicken farms
                                                        

- (Peer Reviewed Journal)Gu, C., Lillehoj, H.S., Sun, Z., Lee, Y., Zhao, H., Xiangyu, Z., Yan, X., Lin, S., Liu, L., Li, C.Z. 2019. Characterization of virulent netB+/tpeI+ clostridium perfringens strains from necrotic-enteritis-affected broiler chicken farms. Avian Diseases. https://doi.org/10.1637/11973-092018-Reg.1.


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