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                    U.S. DEPARTMENT OF AGRICULTURE
 Natural Products Utilization Research: Oxford, MS
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ARS Home Southeast Area Oxford, Mississippi Natural Products Utilization Research People & Locations







Mei  Wang
                        Natural Products Utilization Research

                        




                        
                        Research Chemist
                        Phone: (662) 915-1046
                        
                        
                        Fax: (Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            ProjectsBiobased Pesticide Discovery and Product Optimization and Enhancement from Medicinal and Aromatic Crops
                                                    In-House Appropriated
                                                                    (D)Accession Number: 438514**Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)Comprehensive quality assessment of peppermint oils and commercial products: An integrated approach involving conventional and chiral GC/MS coupled with chemometrics

- (Peer Reviewed Journal)Investigation of morpho-anatomical, molecular, GC/QToF, and LC/QToF characterization of Salvia mellifera (black sage), Saliva apiana (white sage) and their varieties
                                                        

- (Peer Reviewed Journal)Adams, S.J., Lee, J., Avula, B., Katragunta, K., Wang, M., Parveen, I., Techen, N., Chittiboyina, A., Khab, I. 2023. Investigation of morpho-anatomical, molecular, GC/QToF, and LC/QToF characterization of Salvia mellifera (black sage), Saliva apiana (white sage) and their varieties. South African Journal of Botany. 164:77-90. https://doi.org/10.1016/j.sajb.2023.11.038.Proximate composition and nutritional analysis of selected bananas cultivated in Hainan, China
                                                        

- (Peer Reviewed Journal)Tan, L., He, Y., Li, S., Deng, J., Avula, B., Zhang, J., Nirmal, P.D., Solis-Sainz, J., Wang, M. 2023. Proximate composition and nutritional analysis of selected bananas cultivated in Hainan, China. Journal of Food Composition and Analysis. https://doi.org/10.1016/j.jfca.2023.105798.6-Oxofurostane and (iso)spirostane type of saponins in Smilax sieboldii: UHPLC-QToF-MS/MS and GNPS-molecular networking approach for the rapid dereplication and biodistribution of specialized metabolites
                                                        

- (Peer Reviewed Journal)Avula, B., Bae, J., Ahn, J., Wang, Y., Wang, M., Kwon, Y., Chittiboyina, A.G., Khan, I.A. 2023. 6-Oxofurostane and (iso)spirostane type of saponins in Smilax sieboldii: UHPLC-QToF-MS/MS and GNPS-molecular networking approach for the rapid dereplication and biodistribution of specialized metabolites. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms241411487.Chemical characterization and quantitative determination of flavonoids and phenolic acids in yerba santa (Eriodictyon spp.) using UHPLC/DAD/Q-ToF
                                                        

- (Peer Reviewed Journal)Wang, M., Zhao, J., Avula, B., Lee, J., Upton, R., Khan, I. 2023. Chemical characterization and quantitative determination of flavonoids and phenolic acids in yerba santa (Eriodictyon spp.) using UHPLC/DAD/Q-ToF. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2023.115570.Cannabinoid receptor type II  ligands from sandalwood oil and synthetic alpha-santalol derivatives
                                                        

- (Peer Reviewed Journal)Paudel, P., Pandey, P., Paris, J.J., Ashpole, N.M., Mahdi, F., Tian, J., Lee, J., Wang, M., Xu, M., Chittiboyina, A.G., Khan, I.A., Ross, S.A., Li, X. 2023. Cannabinoid receptor type II  ligands from sandalwood oil and synthetic alpha-santalol derivatives. Journal of Natural Products. https://doi.org/10.1021/acs.jnatprod.3c00282.Chemical characterization and quality assessment of copaiba oil-resin using GS/MS and SFC/MS
                                                        

- (Peer Reviewed Journal)Lee, J., Wang, M., Zhao, J., Ali, Z., Hawwal, M., Khan, I. 2023. Chemical characterization and quality assessment of copaiba oil-resin using GS/MS and SFC/MS. Plants. https://doi.org/10.3390/plants12081619.Yerba santa leaves and tops eriodictyon californicum and related species-standards of identity, purity, analysis, and quality control

- (Monograph)Wang, M. 2023. Yerba santa leaves and tops eriodictyon californicum and related species-standards of identity, purity, analysis, and quality control. American Herbal Pharmacopoeia and Therapeutic Compendium. 1.Antiplasmodial and antimicrobial activities of ent-abietane diterpenoids from the roots of Suregada zanzibariensis
                                                        

- (Peer Reviewed Journal)Matundura, J.O., Midiwo, J.O., Yenesew, A., Omosa, L., Kumarihamy, M., Zhao, J., Wang, M., Tripathi, S., Khan, S., Masila, V.M., Nchiozem-Ngnitedem, V., Muhammad, I. 2022. Antiplasmodial and antimicrobial activities of ent-abietane diterpenoids from the roots of Suregada zanzibariensis. Natural Product Research. https://doi.org/10.1080/14786419.2022.2158463.Development of a GC/Q-ToF method coupled with headspace solid-phase microextraction  to evaluate the in vitro metabolism of ß-Caryophyllene
                                                        

- (Peer Reviewed Journal)Lee, J., Wang, M., Mondal, G., Khan, I.A., Yates, C.R. 2022. Development of a GC/Q-ToF method coupled with headspace solid-phase microextraction  to evaluate the in vitro metabolism of ß-Caryophyllene. Molecules. https://doi.org/10.3390/molecules27217441.Synthesis and inhibitory activity of machaeridiol- based novel anti-MRSA and anti-VRE compounds and their profiling for cancer- related signaling pathways
                                                        

- (Peer Reviewed Journal)Kumarihamy, M., Tripathi, S., Balachandran, P., Avula, B., Zhao, J., Wang, M., Bennett, M., Carr, M.A., Micheal, L., Ocean, W.I., Marquart, M.E., Nanayakkara, D., Muhammad, I. 2022. Synthesis and inhibitory activity of machaeridiol- based novel anti-MRSA and anti-VRE compounds and their profiling for cancer- related signaling pathways. Molecules. https://doi.org/10.3390/molecules27196604.Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and traditional sliced mate-rials
                                                        

- (Peer Reviewed Journal)Cao, L., Wang, M., Zhao, J., Peng, L., Cheng, J., Qiu, S., Khan, I., Li, X. 2022. Comparative analysis of chemical profiles of Radix Astragali between ultrafine granular powder and traditional sliced mate-rials. Medicinal Plant Biology. https://doi.org/10.48130/MPB-2022-0004.Utility of fatty acid profile and in vitro immune cell activation for chemical and biological standardization of Arthrospira/Limnospira
                                                        

- (Peer Reviewed Journal)Huh, J., Zhang, J., Hauerová, R., Lee, J., Haider, S., Wang, M., Hauer, T., Khan, I., Chittiboyina, A., Pugh, N. 2022. Utility of fatty acid profile and in vitro immune cell activation for chemical and biological standardization of Arthrospira/Limnospira. Scientific Reports. https://doi.org/10.1038/s41598-022-19590-x.Phytochemical investigation of Egyptian Spinach leaves, a potential
source for antileukemic metabolites: in vitro and in silico study
                                                        

- (Peer Reviewed Journal)Abdelgawad, S.M., Hetta, M.H., Ibrahim, M.A., Balachandran, P., Zhang, J., Wang, M., Fawzy, G.A., El-Askary, H.I., Ross, S.A. 2022. Phytochemical investigation of Egyptian Spinach leaves, a potential source for antileukemic metabolites: in vitro and in silico study. Revista Brasileira de Farmacognosia. https://doi.org/10.1007/s43450-022-00307-0.Metabolite variation and discrimination of five licorice (Glycyrrhiza) species: HPTLC and NMR explorations
                                                        

- (Peer Reviewed Journal)Zhao, J., Wang, M., Sabastian, J.A., Lee, J., Chittiboyina, A.G., Avula, B., Ali, Z., Li, J., Wu, C., Khan, I. 2022. Metabolite variation and discrimination of five licorice (Glycyrrhiza) species: HPTLC and NMR explorations. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2022.115012.Chemical authentication and speciation of Salvia botanicals: an investigation utilizing GC/Q-ToF and chemometrics
                                                        

- (Peer Reviewed Journal)Lee, J., Wang, M., Jianping, Z., Avula, B., Chittiboyinaa, A.G., Khan, I.A. 2022. Chemical authentication and speciation of Salvia botanicals: an investigation utilizing GC/Q-ToF and chemometrics. Foods. https://doi.org/10.3390/foods11142132.Phytochemical investigation of Egyptian riverhemp: a potential
source of antileukemic metabolites
                                                        

- (Peer Reviewed Journal)Abdelgawad, S.M., Hett, M.H., Ibrahima, M.A., Balachandran, P., Zhang, J., Wang, M., Fawzy, G.A., El-Askary, H.I., Ross, S.A. 2022. Phytochemical investigation of Egyptian riverhemp: a potential source of antileukemic metabolites. Journal of Natural Medicine. https://doi.org/10.1155/2022/8766625.Chemometric analysis and chemical characterization for the botanical identification of Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, G. echinata and G. lepidota) using liquid chromatography-quadrupole time of flig
                                                        

- (Peer Reviewed Journal)Avula, B., Bae, J., Chittiboyina, A.G., Wang, Y., Wang, M., Zhao, J., Zulfiqar, A., Li, J., Wu, C., Khan, I.A. 2022. Chemometric analysis and chemical characterization for the botanical identification of Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, G. echinata and G. lepidota) using liquid chromatography-quadrupole time of flig. Journal of Agricultural and Food Chemistry. https://doi.org/10.1016/j.jfca.2022.104679.Agronomy, chemical analysis, and antidiabetic activity of basil (Ocimum species)
                                                        

- (Peer Reviewed Journal)Wang, M., Cantrell, C.L., Matthews, S.T., Paudel, P., Lee, J., Mentreddy, S.R. 2022. Agronomy, chemical analysis, and antidiabetic activity of basil (Ocimum species). Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acsfoodscitech.2c00100?urlappend=%3Fref%3DPDF&jav=VoR&rel=cite-as.A new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculata
                                                        

- (Peer Reviewed Journal)Kamau, R.W., Midiwo, J.O., Mgani, Q.A., Masila, V.M., Kumarihamy, M., Wang, M., Zhao, J., Muhamma, I. 2022. A new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculata. Natural Product Research. https://doi.org/10.1080/14786419.2022.2062349.Comparative analysis of five salvia species using LC-DAD-QToF
                                                        

- (Peer Reviewed Journal)Avula, B., Bae, J., Chittiboyinaa, A.A., Wang, Y., Wang, M., Srivedavyasasri, R., Ali, Z., Li, J., Wu, C., Khan, I.A. 2021. Comparative analysis of five salvia species using LC-DAD-QToF. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114520.Are atranols the only skin sensitizers in oakmoss, a systematic investigation using non-animal methods
                                                        

- (Peer Reviewed Journal)Avonto, C., Chittiboyina, A.G., Khan, S.I., Dale, O.R., Parcher, J.F., Wang, M., Khan, I.A. 2020. Are atranols the only skin sensitizers in oakmoss, a systematic investigation using non-animal methods. Toxicology In Vitro. 70. Article e105053. https://doi.org/10.1016/j.tiv.2020.105053.NMR technique and methodology in botanical health product analysis and quality control
                                                        

- (Peer Reviewed Journal)Zhao, J., Wang, M., Saroja, S.G., Khan, I.A. 2021. NMR technique and methodology in botanical health product analysis and quality control. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114376.Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies
                                                        

- (Peer Reviewed Journal)Shankara, V., Wang, M., Ajjarapua, S., Kolimi, P., Avula, B., Murthy, R., Khan, I., Naraisimha, M. 2021. Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpha.2021.08.004.Chemical constituents and anti-gastric ulcer activity of essential oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and their herbal pair
                                                        

- (Peer Reviewed Journal)Huijuan, Q., Lin, K., Li, X., Ou, H., Tan, Y., Wang, M., Wei, N. 2021. Chemical constituents and anti-gastric ulcer activity of essential oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and their herbal pair. Chemistry and Biodiversity. https://doi.org/10.1002/cbdv.202100214.Synthesis and antifungal activity evaluation of phloeodictine analogues
                                                        

- (Peer Reviewed Journal)Ravu, R., Jacob, M.R., Khan, S.I., Wang, M., Cao, L., Agarwal, A.K., Clark, A.M., Li, X. 2021. Synthesis and antifungal activity evaluation of phloeodictine analogues. Journal of Natural Products. 84,2129-2137. https://doi.org/10.1021/acs.jnatprod.1c00116.(E)-2,6,10-Trimethyldodec-8-en-2-ol: An undescribed sesquiterpenoid from copaiba oil
                                                        

- (Peer Reviewed Journal)Hawwal, M.F., Ali, Z., Wang, M., Zhao, J., Lee, J., Fantoukh, O.I., Khan, I.A. 2021. (E)-2,6,10-Trimethyldodec-8-en-2-ol: An undescribed sesquiterpenoid from copaiba oil. Molecules. 2021, 26, 4456. https://doi.org/10.3390/molecules26154456.Chemical profiling and characterization of anthraquinones from two Bulbine species and dietary supplements using liquid chromatography-high resolution mass spectrometry
                                                        

- (Peer Reviewed Journal)Avula, B., Bae, J., Wang, Y., Wang, M., Ali, Z., Khan, I.A. 2021. Chemical profiling and characterization of anthraquinones from two Bulbine species and dietary supplements using liquid chromatography-high resolution mass spectrometry. Nature Product Communications. https://doi.org/10.1093/jaoacint/qsab075.A novel approach for lavender essential oil authentication and quality assessment
                                                        

- (Peer Reviewed Journal)Wang, M., Zhao, J., Ali, Z., Avonto, C., Khan, I. 2021. A novel approach for lavender essential oil authentication and quality assessment. Journal of Pharmaceutical and Biomedical Analysis. 199. Article e114050. https://doi.org/10.1016/j.jpba.2021.114050.Quantitative determination and characterization of polyphenols from Cissus quadrangularis L. and dietary supplements using UHPLC-PDA-MS, LC-QToF and HPTLC
                                                        

- (Peer Reviewed Journal)Avula, B., Bae, J., Zhao, J., Wang, Y., Wang, M., Zhang, Z., Ali, Z., Khan, I. 2021. Quantitative determination and characterization of polyphenols from Cissus quadrangularis L. and dietary supplements using UHPLC-PDA-MS, LC-QToF and HPTLC. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114036.Cross talk of cancer signaling pathways by cyclic hexapeptides and anthraquinones from Rubia cordifolia
                                                        

- (Peer Reviewed Journal)Balachandran, P., Ibrahim, M.A., Zhang, J., Wang, M., Pasco, D.S., Muhammad, I. 2021. Cross talk of cancer signaling pathways by cyclic hexapeptides and anthraquinones from Rubia cordifolia. Molecules. 26/735. https://doi.org/10.3390/molecules26030735.Antimicrobial constituents from Machaerium Pers.: Inhibitory activities and synergism of machaeriols and machaeridiols against methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecium and perm
                                                        

- (Peer Reviewed Journal)Muhammad, I., Jacob, M.R., Ibrahim, M.A., Raman, V., Kumarihamy, M., Wang, M., Al-Adhami, T., Hind, C., Clifford, M., Martin, B., Sutton, M., Rahman, M., Zhao, J. 2020. Antimicrobial constituents from Machaerium Pers.: Inhibitory activities and synergism of machaeriols and machaeridiols against methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecium and perm. Molecules. 25/6000. https://doi.org/10.3390/molecules25246000.Phenolic contents, chemical profiling, in silico and in vitro antiinflammatory and anticancer properties of Alnus nitida (Spach) Endl
                                                        

- (Peer Reviewed Journal)Shaukat, U., Ahemad, S., Wang, M., Khan, S.I., Ali, Z., Muhammad I, T.I., Abdallah, H.H., Khan, I.A., Saleem, M., Mahomoodally, M.F. 2021. Phenolic contents, chemical profiling, in silico and in vitro antiinflammatory and anticancer properties of Alnus nitida (Spach) Endl. South African Journal of Botany. 138:148-155. https://doi.org/10.1016/j.sajb.2020.12.010.Newly generated Atractylon derivatives in the processed rhizomes of Atractylodes macrocephala Koidz
                                                        

- (Peer Reviewed Journal)Zhai, C., Zhao, J., Chittiboyina, A.G., Meng, Y., Wang, M., Khan, S.I., Khan, I.A. 2020. Newly generated Atractylon derivatives in the processed rhizomes of Atractylodes macrocephala Koidz. Molecules. https://doi.org/10.3390/molecules25245904.Comparative study and quality evaluation regarding morphology characters, volatile constituents and triglycerides in seeds of five species used in traditional Chinese medicine
                                                        

- (Peer Reviewed Journal)Wei, N., Wang, M., Adams, S.J., Yu, P., Avula, B., Wang, Y., Pan, K., Wang, Y., Khan, I.A. 2020. Comparative study and quality evaluation regarding morphology characters, volatile constituents and triglycerides in seeds of five species used in traditional Chinese medicine. Journal of Pharmaceutical and Biomedical Analysis. 194. Article e113801. https://doi.org/10.1016/j.jpba.2020.113801.Effects of Euphorbia umbellata extracts on complement activation and chemotaxis of neutrophils
                                                        

- (Peer Reviewed Journal)De Oliveira, T.L., Fontana, P.D., Bavia, L., Cruz, L., Crisma, A.R., Sassaki, G.L., Menezes, L.R., Wang, M., Beltrame, F., Messias-Reason, I.J. 2020. Effects of Euphorbia umbellata extracts on complement activation and chemotaxis of neutrophils. Journal of Ethnopharmacology. 265/113348. https://doi.org/10.1016/j.jep.2020.113348.Identification of antifungal bisphosphocholines from medicinal Gentiana species
                                                        

- (Peer Reviewed Journal)Ren, S., Deng, K., Qiu, S., Wang, M., Avula, B., Tripathi, S.K., Jacob, M.R., Gong, L., Wang, W., Khan, I.A., Li, X. 2020. Identification of antifungal Bisphosphocholines from medicinal Gentiana species. Journal of Natural Products. 2020, 83, 10, 3207–3211. https://doi.org/10.1021/acs.jnatprod.0c00584.A comprehensive workflow for the analysis of Bio-Macromolecular supplements: Case Study of 20 Whey protein products
                                                        

- (Peer Reviewed Journal)Avula, B., Parveen, I., Zhao, J., Wang, M., Techen, N., Wang, Y., Riaz, M., Bae, J., Shami, A.A., Chittiboyina, A.G., Khan, I.A., Sharp, J.S. 2021. A comprehensive workflow for the analysis of Bio-Macromolecular supplements: Case Study of 20 Whey protein products. Journal of Dietary Supplement. https://doi.org/10.1080/19390211.2021.1897724.


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