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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549





FORM 10-K







|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended December 31, 2010

or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from  to

Commission file number: 033-17264-NY





IMMUNOCELLULAR THERAPEUTICS, LTD.

(Exact name of registrant as specified in its charter)







|                                                               |  |                                       
|-------------------------------------------------------------- |  | --------------------------------------
|Delaware                                                       |  | 93-1301885                            
|(State or other jurisdiction of incorporation or organization) |  | (I.R.S. EmployerIdentification Number)
|                                                               | 
|21900 Burbank Boulevard, 3rdFloor Woodland Hills, California   |  | 91367                                 
|(Address of principal executive offices)                       |  | (Zip Code)                            

Registrants telephone number, including area code: (818) 992-2907





Securities registered pursuant to Section 12(b) of the Exchange Act: None

Securities registered pursuant to Section 12(g) of the Exchange Act: None





Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities
Act.     ̈  Yes    x  No

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Exchange
Act.     ̈  Yes    x  No

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Exchange Act during the past 12 months (or for such shorter period that
the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    x  Yes     ̈  No

Indicate by check mark whether the registrant has submitted electronically and
posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit
and post such files).     ̈  Yes     ̈  No

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained,
to the best of the registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K.  x

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller
reporting company. See the definitions of large accelerated filer, accelerated filer, and smaller reporting company in Rule 12b-2 of the Exchange Act (Check one):



|                           |  |                      |  |                          |  |                             
|-------------------------- |  | -------------------- |  | ------------------------ |  | ----------------------------
|Large accelerated filer   ̈ |  | Accelerated filer   ̈ |  | Non-accelerated filer   ̈ |  | Smaller reporting company  x

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act):     ̈  Yes    x  No

The aggregate market value of the common stock held by non-affiliates of the registrant as of June 30, 2010 (the last business day of the registrants most recently completed second fiscal
quarter) was approximately $23,065,468.

There were 28,725,624 shares of the registrants common stock outstanding on March 1, 2011.

Documents incorporated by reference: None









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Table of Contents

Form 10-K





|         |  |                                                                                                              |  |      |    | 
|-------- |  | ------------------------------------------------------------------------------------------------------------ |  | ---- | -- | 
|         |  |                                                                                                              |  | Page |   
|         |  |                                                                                                             
|         |  | PART I                                                                                                       |  |      | 1  | 
|         |  |                                                                                                             
|Item 1.  |  | Business                                                                                                     |  |      | 1  | 
|Item 1A. |  | Risk Factors                                                                                                 |  |      | 14 | 
|Item 1B. |  | Unresolved Staff Comments                                                                                    |  |      | 28 | 
|Item 2.  |  | Properties                                                                                                   |  |      | 28 | 
|Item 3.  |  | Legal Proceedings                                                                                            |  |      | 28 | 
|Item 4.  |  | (Removed and Reserved)                                                                                       |  |      | 28 | 
|         |  |                                                                                                             
|         |  | PART II                                                                                                      |  |      | 28 | 
|         |  |                                                                                                             
|Item 5.  |  | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities |  |      | 28 | 
|Item 6.  |  | Selected Financial Data                                                                                      |  |      | 29 | 
|Item 7.  |  | Managements Discussion and Analysis of Financial Condition and Results of Operations                        |  |      | 29 | 
|Item 7A. |  | Quantitative and Qualitative Disclosures About Market Risk                                                   |  |      | 34 | 
|Item 8.  |  | Financial Statements and Supplementary Data                                                                  |  |      | 34 | 
|Item 9.  |  | Changes in and Disagreements with Accountants on Accounting and Financial Disclosure                         |  |      | 34 | 
|Item 9A. |  | Controls and Procedures                                                                                      |  |      | 34 | 
|Item 9B. |  | Other Information                                                                                            |  |      | 35 | 
|         |  |                                                                                                             
|         |  | PART III                                                                                                     |  |      | 35 | 
|         |  |                                                                                                             
|Item 10. |  | Directors, Executive Officers and Corporate Governance                                                       |  |      | 35 | 
|Item 11. |  | Executive Compensation                                                                                       |  |      | 42 | 
|Item 12. |  | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters               |  |      | 52 | 
|Item 13. |  | Certain Relationships and Related Transactions, and Director Independence                                    |  |      | 54 | 
|Item 14. |  | Principal Accounting Fees and Services                                                                       |  |      | 54 | 
|         |  |                                                                                                             
|         |  | PART IV                                                                                                      |  |      | 55 | 
|         |  |                                                                                                             
|Item 15. |  | Exhibits and Financial Statement Schedules                                                                   |  |      | 55 | 



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Introductory Comment

Throughout this Annual Report on Form 10-K, the terms we, us, our, our company,
Company and the Registrant refer to ImmunoCellular Therapeutics, Ltd., a Delaware corporation, formerly known as Optical Molecular Imaging, Inc. and Patco Industries, Ltd., and, unless the context indicates otherwise, also
include our former subsidiary, Spectral Molecular Imaging, Inc., a Nevada corporation, which we sold in September 2006.

Safe Harbor Statement

From time to time, we make oral and written statements that may constitute forward-looking statements (rather than historical facts) as defined in the Private Securities Litigation Reform Act
of 1995 or by the Securities and Exchange Commission (the SEC) in its rules, regulations and releases, including Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as
amended (the Exchange Act). We desire to take advantage of the safe harbor provisions in the Private Securities Litigation Reform Act of 1995 for forward-looking statements made from time to time, including the
forward-looking statements made in this Annual Report, as well as those made in our other filings with the SEC.

All
statements in this Annual Report, including under the captions Business, Risk Factors, and Managements Discussion and Analysis of Financial Condition and Results of Operations, other than statements of
historical fact are forward-looking statements for purposes of these provisions, including statements of our current views with respect to our business strategy, business plan and research and development activities, our future financial results,
and other future events. These statements include forward-looking statements both with respect to us, specifically, and the biotechnology industry, in general. In some cases, forward-looking statements can be identified by the use of terminology
such as may, will, expects, plans, anticipates, estimates, potential or could or the negative thereof or other comparable terminology. Although we
believe that the expectations reflected in the forward-looking statements contained herein are reasonable, there can be no assurance that such expectations or any of the forward-looking statements will prove to be correct, and actual results could
differ materially from those projected or assumed in the forward-looking statements.

All forward-looking statements involve
inherent risks and uncertainties, and there are or will be important factors that could cause actual results to differ materially from those indicated in these statements. We believe that these factors include, but are not limited to, those factors
set forth in this Annual Report under the captions Business, Risk Factors, and Managements Discussion and Analysis of Financial Condition and Results of Operations, all of which you should review carefully.
If one or more of these or other risks or uncertainties materialize, or if our underlying assumptions prove to be incorrect, actual results may vary materially from what we anticipate. Please consider our forward-looking statements in light of those
risks as you read this Annual Report. We undertake no obligation to publicly update or review any forward-looking statement, whether as a result of new information, future developments or otherwise.

PART I



|Item 1. | Business.
|------- | ---------

Overview

ImmunoCellular Therapeutics, Ltd. is a development stage company that is seeking to develop and commercialize new therapeutics to fight
cancer using the immune system. Our product candidate portfolio includes cellular immunotherapies targeting cancer and cancer stem cell antigens, peptide based immunotherapies targeting cancer stem cells, and monoclonal antibodies to diagnose and
treat several different cancers. We have completed a Phase I clinical trial of our dendritic cell based vaccine product candidate (ICT-107) to treat newly diagnosed glioblastoma multiforme (GBM) that was initiated in May 2007, and we initiated a
multicenter Phase II clinical trial of this vaccine in January 2011. This product candidate may also



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be efficacious in the treatment of recurrent GBM, and we are planning to initiate a pilot trial of this vaccine for this indication in 2011. Another one of our vaccine product candidates is a
peptide based off-the-shelf vaccine (ICT-121) to target multiple solid tumors which is undergoing preclinical development. This vaccine targets cancer stem cells, which are believed by many scientists to be roots of cancer, and may be applicable in
multiple cancer indications. In addition, we have several monoclonal antibody product candidates targeting small cell lung cancer, pancreatic cancer, multiple myeloma and ovarian cancer. Through two important acquisitions in the last five years, we
are building capabilities to develop new cancer immunotherapeutic products harnessing mechanisms of immune system surveillance in the human body.

In November 2006, we acquired an exclusive, worldwide license from Cedars-Sinai Medical Center to certain technology for use as cellular-based therapies, including dendritic cell-based vaccines for
neurological disorders that include brain tumors and neurodegenerative disorders and other cancers. This technology is covered by a number of pending U.S. and foreign patent applications. In June 2008, we licensed an additional technology from
Cedars-Sinai to target cancer stem cells that may be applicable for brain tumors as well as several other cancer indications.

In February 2008, we entered into an agreement with Molecular Discoveries LLC, a New York limited liability company, covering our
acquisition of certain monoclonal antibody related technology owned by Molecular Discoveries and completed the acquisition of the technology on that date. The technology acquired under the Molecular Discoveries agreement and now owned by us consists
of (i) a platform technology referred to by Molecular Discoveries as DIAAD for the potentially rapid discovery of targets (antigens) and monoclonal antibodies for diagnosis and treatment of diverse human diseases and (ii) certain
monoclonal antibody candidates for the potential detection and treatment of multiple myeloma, small cell lung, pancreatic and ovarian cancers. The monoclonal antibodies are covered by issued patents and pending patent applications in the fields of
multiple myeloma, small cell lung and ovarian cancers.

We do not currently anticipate that we will derive any revenues from
either product sales or licensing during the foreseeable future. We do not have any bank credit lines and have financed substantially all of our prior operations through the sale of securities, including a private placement of our securities that we
completed in February 2011 that generated $8,090,644 of proceeds for us (before commissions and offering expenses).

The
estimated cost of completing the development of either of our current vaccine product candidates and of obtaining all required regulatory approvals to market either of those product candidates is substantially greater than the amount of funds we
currently have available. We believe that our existing cash balances, together with potential proceeds from our preferred stock purchase arrangement with Socius Capital Group, LLC, will be sufficient to fund our currently planned level of operations
for at least the next twelve months. We will seek to obtain additional funds through various financing sources, including possible sales of our securities, and in the longer term through strategic alliances with other pharmaceutical or
biopharmaceutical companies, but there can be no assurance that we will be able to obtain any additional funding from any potential financing sources, or create any such alliances, or that the terms under which we would obtain any funding will be
sufficient to fund our operations.

Company History

We filed our original Certificate of Incorporation with the Secretary of State of Delaware on March 20, 1987 under the name Redwing Capital Corp. On June 16, 1989, we changed our name to Patco
Industries, Ltd. and conducted an unrelated business under that name until 1994. On January 30, 2006, we amended our Certificate of Incorporation to change our name to Optical Molecular Imaging, Inc. in connection with our merger on
January 31, 2006 with Spectral Molecular Imaging, Inc. On November 2, 2006, we amended our Certificate of Incorporation to change our name to ImmunoCellular Therapeutics, Ltd. to reflect our disposition of our Spectral Molecular Imaging
subsidiary and our acquisition of our cellular-based technology from Cedars-Sinai.

Our principal
executive offices are located at 21900 Burbank Boulevard,
3rdFloor, Woodland Hills, California 91367, and our
telephone number at that address is (818) 992-2907.



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Technology and Proposed Products

Overview

The table below summarizes the status of our product candidates



|                                                                     |  |                                                               |  |                 
|-------------------------------------------------------------------- |  | ------------------------------------------------------------- |  | ----------------
|Product candidate                                                    |  | Target Indication                                             |  | Status          
|                                                                     |  |                                                              
|Active Immunotherapy:                                                |  |                                                               |  |                 
|                                                                     |  |                                                              
|ICT-107 (DC vaccine targeting cancer stem cells and cancer antigens) |  | Newly Diagnosed Glioblastoma                                  |  | Phase II ongoing
|                                                                     |  |                                                              
|ICT-121 (off-the-shelf cancer stem cell vaccine)                     |  | Glioblastoma, Pancreatic cancer and other solid tumor cancers |  | Pre-clinical    
|                                                                     |  |                                                              
|Monoclonal Antibodies:                                               |  |                                                               |  |                 
|                                                                     |  |                                                              
|ICT-109 (Monoclonal Antibody)                                        |  | Lung and pancreatic and colon cancer therapeutic              |  | Pre-clinical    
|                                                                     |  |                                                              
|ICT-037 (Monoclonal Antibody)                                        |  | Colon, ovarian, multiple myeloma therapeutic and diagnostic   |  | Pre-clinical    
|                                                                     |  |                                                              
|ICT-69 (Monoclonal Antibody)                                         |  | Multiple myeloma and ovarian cancer                           |  | Pre-clinical    
|                                                                     |  |                                                              
|ICT-Diagnostic-SCLC                                                  |  | Diagnostic/Prognostic for small cell lung cancer              |  | Pre-clinical    

Cancer is caused by abnormal
cells that grow in an uncontrolled manner. These cells proliferate and metastasize throughout the body causing tumors which can cause organ failure and death. The current treatments such as surgery, radiation and chemotherapy have limited
therapeutic effects and significant undesirable side effects. Our approach is to harness the bodys immune system to provide therapeutics with the ability to fight cancer. There are two arms of the immune system that provide natural protection
to the body: the cellular immune system (T-cell based) and the humoral immune system (B-cell based), which uses antibodies to fight foreign invaders. Our strategy is to utilize both of these mechanisms in our product development programs. We believe
that the synergy between the two types of immunity can be powerful. Elicitation of a cellular immune response has the potential of long-term protection against malignant diseases, while infusion of monoclonal antibodies (concentrated product of the
humoral response) has the capacity to confer an immediate shield against the disease. The latter is especially important in cases where the patients immune system is compromised due to toxic treatment of the disease and cannot mount an
adequate response to the active vaccine. In some situations a combination of a passive vaccine (monoclonal antibodies) aimed at halting the dissemination of cancer cells through the blood followed by an active vaccine when the patient recuperates
may constitute an effective synergistic approach.

Active Immunotherapy

One of our product strategies is the development of cell-based vaccine products that could bolster the bodys natural tendency
through its immune system to defend it against malignant brain tumors. We have been developing two forms of these vaccines, one based on cancer stem cells and one based on dendritic cells.

The high rate of mortality of patients diagnosed with brain cancers and in particular with glioblastoma multiforme (the most lethal and
devastating form) is driving the scientific community to discover and develop improved treatments that could increase the survival time and enhance the quality of life of patients. Of the approximately 19,000 cases of malignant brain and spinal cord
tumors that are diagnosed each year in the



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United States, there currently is no satisfactory treatment, and the two-year survival rates are only in the range of 26%. Neither surgery, radiation nor anti-cancer drugs, the standard treatment
modalities, have shown to date any prospect of meaningful extension of patients lives. We and others in the medical research community believe that immunotherapy has the potential, in the not too distant future, to be teamed with other
treatment modalities to become an integral part of mainstream medical practice in the treatment of patients with brain tumors.

Dendritic Cell Vaccines

Dendritic cells (human derived cells
responsible for antigen processing and presentation to the immune system) play a central role in the bodys immune response. They trigger the systems that help the body fight infection or foreign bodies, by initiating a T cell or
T cell response to the infection or foreign body. The dendritic cells do this by recognizing, processing and presenting foreign antigens (substances that stimulate the production of antibodies and combine specifically with them) to the
T cells, which then effectuate the immune response. The goal of a cell-based vaccine is to (i) make use of and enhance the dendritic cells ability to trigger the T cell response and (ii) to stimulate the dendritic cell to
focus the T cell response to specifically target the cancer cells for destruction.

Even though dendritic cells can be
very potent, they are usually not present in sufficient numbers to permit an adequately potent immune response to fight cancer. What is more, dendritic cells often do not react aggressively to malignant tumors; they do not treat the tumor as a
foreign body that needs to be destroyed or neutralized. Dendritic cells are powerful potentiators of acquired immunity through an effective presentation of the cancer antigens to T cells which subsequently mediate the killing of the cancer cells.
Thus, dendritic cells are critical facilitators of T cell response. Dendritic cell therapy generally involves harvesting dendritic cells from a patient, then culturing and processing them in a laboratory to produce more numerous and effective
dendritic cells. In the laboratory, the dendritic cells are cultured with specific antigens that are on tumor cells to enable the dendritic cells to recognize cancer cells as targets for attack. When the newly cultured dendritic cells are injected
back into the patient, they seek out remaining tumor cells and signal the T cells to destroy them.

Peptide Vaccines Targeting Cancer Stem Cells

Cancer stem cells are considered as a subset of cancerous cells which are responsible for the growth and re-growth of the primary and
metastatic tumors. Complete eradication of tumor masses requires elimination of these cells, which are resistant to standard chemotherapy and radiation therapy. There are a number of markers that have been identified on various cancer stem cells
which could be exploited for targeting these cells. We are utilizing peptides in combination with an adjuvant that can elicit an immune response in the body by triggering T cells to identify and destroy these cancer stem cells. These peptides were
specifically designed to elicit a T cell response targeting CD133 positive cancer stem cells that have been identified in a number of cancer types, including gliomas, colon cancer and pancreatic cancer.

Antibody Immunotherapy

Another strategy for our product development is to harness the other arm of the immune system, which uses antibodies that can bind and neutralize any foreign antigen. These antibodies are produced by the
B-lymphocytes (B-cells), and each antibody recognizes only one antigen. The antibodies we have acquired from Molecular Discoveries have been created to recognize certain antigens primarily expressed on the cancer cells and not expressed on the
normal cells, such that binding to those antigens can lead to death of the tumor cells. We also have acquired an antibody development platform called DIAAD from our technology acquisition from Molecular Discoveries, which may enable us to discover
and develop novel antigens and antibodies for cancer cells.



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ICT-107: Dendritic Cell-Based Vaccine Targeting Tumor Associated Antigens

Current treatment of glioblastoma multiforme and other brain cancers involves a combination of surgery, radiation treatment, and
chemotherapy. A significant issue with chemotherapy is that even as the chemicals become more powerful and more specifically targeted at a tumors DNA, the tumors cells may outmaneuver the chemotherapy by mutating or otherwise
repulsing the attack. However, by combining chemotherapy with a cell-based immunotherapy treatment regimen, it appears that this could potentially enhance chemotherapy sensitivity and thereby improve patient treatment.

In a number of laboratory and clinical trials, dendritic cell immunotherapy has succeeded in eliciting a powerful immune response against
brain tumor cells, but without achieving significant improvement in length of survival. Similarly, chemotherapy, even using agents specifically designed to attack the DNA of tumor cells and prevent their replication, becomes ineffective as the tumor
cells develop drug resistance.

By combining chemotherapy and immunotherapy in a two wave approach, we believe
that more promising results may be achievable. This would combine a first wave of a dendritic cell-based vaccine that is specifically formulated using highly immunogenic tumor antigens designed to destroy tumor cells and their ability to mutate,
followed by a second wave of targeted chemotherapy targeted against the remaining cancer cells that have had their ability to mutate significantly impaired or destroyed by the vaccine.

Dr. Yu completed two clinical trials at Cedars-Sinai prior to his association with our company using dendritic cells loaded with
tumor lysates derived from the patients cancer to generate an immune response against intracranial tumors. The results of these early studies preliminarily demonstrated the safety of dendritic cell vaccination as well as biological efficacy in
generating specific anti-tumor T cell responses. Based upon some additional pre-clinical research, Dr. Yu and his Cedars-Sinai team have developed what they believe could be a new, improved dendritic cell-based therapeutic vaccine, ICT-107.

ICT-107 is a new generation dendritic cell-based therapeutic vaccine that consists of a number of specific tumor antigens
which, when loaded onto the dendritic cells, are expected to stimulate the bodys T cells to target only these specific proteins on the patients tumor cells. This product candidate is an intradermal dendritic cell-based therapeutic
vaccine that we plan to use with chemotherapy concomitantly or subsequent to conventional therapy in patients with first diagnosed or recurrent glioblastoma.

We have tested ICT-107 in a Phase I clinical trial at Cedars-Sinai in patients with glioblastoma. The trial enrolled 19 patients and the vaccine was well tolerated, with no significant adverse events
reported. Of the 16 newly diagnosed GBM patients treated in this trial, 11 patients are still alive, with 3 patients surviving at least 3 years after the surgery that preceded their vaccine treatment. Of the 11 patients who are still alive, 3 of the
patients are completely free of the disease after 3 years, and an additional 3 of these patients are completely free of the disease after 2 years. The median progression free survival in the 16 newly diagnosed patients enrolled in the trial was 17
months and 6 of these 16 patients continue to show no signs of tumor recurrence at the present time.

In January 2010, we
reported the results of a study in which it was shown that certain specific antigens are highly expressed on cancer stem cells. This suggests that ICT-107, which targets those antigens, potentially may effectively target not only the cells that make
up the bulk of certain cancerous tumors, but also the cancer stem cells that are widely believed to give rise to them and to cause their recurrence.

In June 2010, ICT-107 was granted Orphan Drug status by the FDA, making this product candidate eligible, under certain circumstances, for marketing exclusivity and other potential benefits.

On September 1, 2010, we entered into a Master Services Agreement (the MSA) with Averion International Corp., a clinical
research organization (Averion). Under the MSA, Averion will provide us with clinical trial support services in connection with and over the course of our Phase II clinical trial for ICT-107, our lead product candidate for the treatment
of brain cancer. Under the MSA, Averion will oversee the enrollment of patients and execution of our Phase II trial. The MSA, which may be terminated by us at any



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time, provides for a limit of approximately $3.5 million on the fees that we will be obligated to pay Averion if all of the planned services are actually provided.

In January 2011, we entered into a sponsored research and vaccine production agreement with the University of Pennsylvania under which
that institution, which has assisted us in optimizing the formulation of ICT-107 that we are using in our Phase II trial of that vaccine, will assist us in the GMP production of supplies of that vaccine for this trial.

ICT-121: Cancer Stem Cell Vaccine For Glioblastoma Multiforme

The laboratory at Cedars-Sinai Medical Center of Dr. John Yu, our Chairman of the Board and the Director of Surgical Neurooncology at
the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai, was instrumental in identifying the cancer stem cells in glioblastoma. The characterization of cancer stem cells from glioblastoma has provided an opportunity to study the etiology of this
dreaded disease and to be engaged in the development of product candidates that would be able to target the cancer stem cells which are believed to be responsible for the initiation and maintenance of glioblastoma. Dr. Yu and his team have
identified several peptides that can elicit an immune response targeting CD133, a common marker present on most cancer stem cells. These peptides are specific to certain HLA markers in humans.

Our vaccine product candidate, ICT-121, is a peptide that can elicit an immune response in a HLA-A*0201 serotype patient population to
target CD133 positive cancer stem cells in brain tumors and other cancers. HLA is the molecule by which protein segments are presented to the immune system by antigen presenting cells. HLA-A2 represents the most prevalent HLA Class I type in North
America. The current treatment of glioblastoma and other brain cancers involves a combination of surgery, radiation treatment and chemotherapy. One of the significant issues with this treatment is the recurrence of tumors after a few months of
treatment, which may be due to cancer stem cells left intact as these cells are resistant to chemotherapy as well as radiation therapy. By combining conventional treatment with a vaccine to target remaining cancer stem cells, one could potentially
significantly delay or eliminate recurrence of these tumors.

We are currently conducting additional preclinical studies to
support an IND filing that we are targeting for ICT-121 in 2011. Subject to successfully obtaining the necessary preclinical data, we plan to initiate a Phase I clinical trial for this vaccine after the IND filing has been cleared by the FDA.
This trial will be a multi-center clinical trial in both recurrent as well as newly diagnosed patients with clinical as well as immunological response as the end points. We plan to enroll 15-20 patients for this trial.

Monoclonal Antibodies Targeting Cancer

We acquired from Molecular Discoveries several monoclonal antibodies that react with small cell lung cancer cells, bind to the molecular structure and kill those cells in vitro. The survival rate is
significantly higher when the disease is still localized, but only 16% of lung cancers are diagnosed at this early stage according to the American Cancer Society. Thus, the creation of new screening, monitoring and diagnostic tests for early
detection and disease follow-up of small cell lung cancer may save many lives and prolong the survival of patients afflicted with this devastating disease.

In collaboration with George Mason University, we recently completed a pilot study evaluating the cancer detection abilities of one of our monoclonal antibody product candidates, ICT-109. Data from this
study demonstrated that ICT-109 had a statistically significant ability to discriminate between cancerous and non-cancerous samples, suggesting the potential to detect pancreatic and lung cancer in plasma and serum study sets. The study used reverse
phase micro array technology to determine serum and plasma expression levels of glycosylated CEA, and was performed in collaboration with Dr. Emanuel Petricoin at George Mason University. Researchers at George Mason University investigated the
ability of ICT-109 to detect pancreatic and lung cancer by binding specifically to glycosylated epitopes of CEA-CAM6 and CEA-CAM5, two common markers that are overly expressed in a majority of cancers. Glycosylated CEA is highly expressed in
patients with pancreatic and lung cancers, and can be used to detect these cancers using a direct blood test. As CEA-CAM5 and CEA-CAM6 are also present on the normal tissue, any commercial product would require adding additional markers for
developing a test with higher sensitivity and specificity.



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Small cell lung cancer is the most aggressive form of lung cancer tethered with cigarette
smoking. Small cell lung cancer cases are estimated to constitute about 13% of all lung cancer cases. In the United States, the American Cancer Society estimated 210,000 new lung cancer cases, as well as 161,000 deaths, occurred in 2008. Early
diagnosis of small cell lung cancer is very difficult, and consequently, the vast majority of patients manifest an established cancer with metastasis at the time of diagnosis.

DIAAD utilizes immunological tolerization to accelerate the discovery of the molecular differences between diseased cells and their normal counterparts. The monoclonal antibodies produced by DIAAD provide
the basis for the discovery and development of our potential diagnostic and therapeutic products.

DIAAD enhances the antibody
response of laboratory animals to disease-specific antigens. Antibodies are proteins produced by the bodys immune system that target and selectively bind antigens found on the surface of cancer cells or cells invaded by pathogens such as
bacteria and viruses. There are billions of antibodies, each capable of recognizing and binding a different and specific antigen. Antibodies produced from a single B cell are termed monoclonal and represent one unique protein sequence
with a unique specificity and affinity.

Conventional methods of monoclonal antibody discovery involve immunizing a laboratory
animal with diseased cells. Since the majority of the antigens expressed by the diseased cells are also present on normal cells, the vast majority of the antibodies produced also bind to the normal cells. The discovery of antibodies that bind only
to the diseased cell involves a lengthy screening process to remove antibodies reacting with normal tissues. Thus, the screen for such an antibody is often exhaustive and time consuming and entails testing thousands of antibodies for their ability
to bind selectively to the diseased cell.

DIAAD focuses the immune response on the tumor antigens by first eliminating the
immune response directed against antigens on the normal cells. This is done by a process immunologists call tolerization, which is followed by immunizing the tolerized animals with prostate cancer cells. This directs the immune response towards only
those antigens that are present on the cancerous but not on the normal cells.

We have conducted limited development
activities for our monoclonal antibody product candidates, ICT-37 and ICT-109, for the diagnosis and treatment of small cell lung cancer and pancreatic cancer. We initiated a collaboration with Antitope, Ltd (UK) to humanize these antibodies by
using their proprietary technologies, which was completed in August 2009. In light of the potential need to access other technology to combine our antibodies with other cancer killing technologies and the significant projected pre-clinical
development costs for these antibodies, we plan during 2011 to continue to seek partners or licensees to develop these product candidates.

We also have another antibody product candidate, ICT-69, which targets ovarian cancer and multiple myeloma. ICT-69 was designed using our DIAAD (differential immunization for antigen and antibody
discovery) technology with the purpose of targeting human multiple myeloma and ovarian cancer cells. In September 2009, we entered into a research and option license agreement with Roche Group, a leading global pharmaceutical company, giving them an
option to acquire a license to develop and commercialize ICT-69, our monoclonal antibody product candidate targeting multiple myeloma and ovarian cancer. In September 2010, the Roche Group advised us that it had elected to not exercise this option
to acquire a license to develop and commercialize ICT-69.

These monoclonal antibody programs are at a pre-clinical stage of
development and will require further development before an IND can be potentially filed for human testing. We expect our potential partners or licensees to do this development work.

Cedars-Sinai Agreements

In November 2006, we entered into a license agreement with Cedars-Sinai under which we acquired an exclusive, worldwide license to our technology for use as cellular therapies, including dendritic
cell-based vaccines for neurological disorders that include brain tumors and neurodegenerative disorders and other



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cancers. This technology is covered by a number of pending U.S. and foreign patent applications, and the term of the license will be until the last to expire of any patents that are issued
covering this technology.

As an upfront licensing fee, we issued Cedars-Sinai 694,000 shares of our common stock and paid
Cedars-Sinai $62,000. Additional specified milestone payments will be required to be paid by us to Cedars-Sinai with respect to our first product when we initiate patient enrollment in our first Phase III clinical trial and when we receive FDA
marketing approval for our first product. If both of these milestones are met, the required milestone payments will total $1,250,000.

In June 2008, we licensed through an amendment to our original license agreement with Cedars-Sinai an additional cancer stem cell vaccine technology from Cedars-Sinai for which we paid 100,000 shares of
our common stock.

We have agreed to pay Cedars-Sinai specified percentages of our gross revenues from sales of products (a
percentage in the mid-single digits) and of all of our sublicensing income based on the licensed technology, subject to a reduction if we must make any payments to any third party whose proprietary rights would be infringed by sale of the products.
To maintain our rights to the licensed technology, we must meet certain development and funding milestones.

In September
2010, we entered into a sponsored research agreement with Cedars-Sinai under which Cedars-Sinai will provide services to us in developing standard operating procedures for dendritic cell vaccine preparations at a total cost of up to $446,000.

Molecular Discoveries Agreement

In February 2008, we entered into an agreement with Molecular Discoveries covering our acquisition of certain monoclonal antibody related technology owned by Molecular Discoveries and completed the
acquisition of the technology on that date. The Molecular Discoveries Agreement also was acknowledged and agreed to by Dr. Cohava Gelber, an inventor of the technology acquired by us under this agreement and an equity owner of Molecular
Discoveries. We have retained Dr. Gelber as a consultant to assist us in developing the acquired technology.

The
technology acquired under the Molecular Discoveries agreement and now owned by us consists of (i) a platform technology referred to by Molecular Discoveries as DIAAD for the potentially rapid discovery of monoclonal antibodies to detect and
treat cancer and other chronic diseases and (ii) certain monoclonal antibody candidates for the potential detection and treatment of multiple myeloma, small cell lung, pancreatic and ovarian cancers. The monoclonal antibodies are covered by
issued patents and pending patent applications in the fields of multiple myeloma, small cell lung and ovarian cancers. The consideration that we paid for the acquired technology consisted of (i) the issuance of 800,000 shares of our common
stock to Molecular Discoveries and (ii) our reimbursement to Molecular Discoveries or its managing member of $250,000 of previously incurred patent expenses.

Competition

The pharmaceutical and biopharmaceutical industry is
characterized by intense competition and rapid and significant technological changes and advancements. Many companies, research institutions and universities are doing research and development work in a number of areas similar to those that we focus
on that could lead to the development of new products which could compete with and be superior to our product candidates.

Most of the companies with which we compete have substantially greater financial, technical, manufacturing, marketing, distribution and
other resources than those of ours. A number of these companies may have or may develop technologies for developing products for treating various diseases that could prove to be superior to ours. We expect technological developments in the
pharmaceutical and biopharmaceutical and related fields to occur at a rapid rate, and we believe competition will intensify as advances in these fields are made. Accordingly, we will be required to continue to devote substantial resources and
efforts to research



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and development activities in order to potentially achieve and maintain a competitive position in this field. Products that we develop may become obsolete before we are able to market them or to
recover all or any portion of our research and development expenses. We will be competing with respect to our products with companies that have significantly more experience in undertaking preclinical testing and human clinical trials with new or
improved therapeutic products and obtaining regulatory approvals of such products. A number of these companies already market and may be in advanced phases of clinical testing of various drugs that may compete with our lead product candidate or any
future product candidates. Our competitors may develop or commercialize products more rapidly than we do or with significant advantages over any products we develop. Our competitors may therefore be more successful in commercializing their products
than we are, which could adversely affect our competitive position and business.

In addition to larger pharmaceutical or
biopharmaceutical companies that may develop different competing technologies or technologies within the stem cell field, we will be competing with a number of smaller biotechnology companies that are focused on cellular therapy technologies, which
may include among others Dendreon, Northwest Biotherapeutics, Antigenics, Celldex Therapeutics, NeuralStem, Geron, NeuroNova, ReNeuron, Stemcells, Inc., Advanced Cell Technology and Osiris Therapeutics. Dendreon has received FDA marketing approval
for a prostrate cancer vaccine utilizing dendritic cells, Northwest Biotherapeutics is developing a dendritic cell-based vaccine treating brain tumors, and Celldex Therapeutics has recently completed a Phase II clinical trial to treat glioblastoma
with their cancer vaccines, and other companies may also be developing vaccines of this type.

A number of
monoclonal antibody products currently are being marketed for the treatment of cancer, including Rituxan®,
Herceptin®, Compath®, Avastin®, Erbitux®, Vectibix®, Zevatin®, and Bexxar®, and numerous other monoclonal antibody based products are under development for the treatment of cancer. In the
monoclonal antibody space, we will be directly competing against a number of other well-established pharmaceutical and biotech companies such as Genentech, Seattle Genetics, Immunomedica, Medarex, Immunogen and others. Several of these companies are
also targeting lung, pancreatic and colon cancer.

Colleges, universities, governmental agencies and other public and private
research organizations are becoming more active in seeking patent protection and licensing arrangements to collect royalties for use of technologies that they have developed, some of which may be directly competitive with our lead product candidate
or any future product candidates. The governments of a number of foreign countries are aggressively investing in cellular therapy research and promoting such research by public and private institutions within those countries. These domestic and
foreign institutions and governmental agencies, along with pharmaceutical and specialized biotechnology companies, can be expected to compete with us in recruiting qualified scientific personnel.

Our competitive position will be significantly impacted by the following factors, among others:



| |  |  | our ability to obtain FDA marketing approval for our product candidates on a timely basis
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | the level of acceptance of our products by physicians, compared to those of competing products or therapies
| | - |  | -----------------------------------------------------------------------------------------------------------



| |  |  | our ability to have our products manufactured on a commercial scale
| | - |  | -------------------------------------------------------------------



| |  |  | the effectiveness of sales and marketing efforts on behalf of our products
| | - |  | --------------------------------------------------------------------------



| |  |  | our ability to meet demand for our products
| | - |  | -------------------------------------------



| |  |  | our ability to secure insurance reimbursement for our products candidates
| | - |  | -------------------------------------------------------------------------



| |  |  | the price of our products relative to competing products or therapies
| | - |  | ---------------------------------------------------------------------



| |  |  | our ability to recruit and retain appropriate management and scientific personnel
| | - |  | ---------------------------------------------------------------------------------



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| |  |  | our ability to develop a commercial scale research and development, manufacturing and marketing infrastructure either on our own or with one or more
future strategic partners.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Intellectual Property

Our dendritic cell based vaccine and cancer stem cell vaccine product candidates are currently covered by seven patent applications that
have been filed in the United States and by patent applications that have been filed in certain foreign countries.

In
addition, we have acquired exclusive worldwide ownership rights to eight granted U.S. and ten other patents for various European and Asian territories as well as several U.S. and foreign patent applications through our acquisition of the monoclonal
antibody related technology from Molecular Discoveries. The issued patents relate to monoclonal antibodies targeting various cancers, including human myeloma, ovarian cancer and small cell lung cancer and have expiration dates ranging from 2019 to
2023.

Employees

We have three full-time employees, including our President and Chief Executive Officer and our Vice-President  Product Development and Manufacturing. Our Chairman of the Board and Chief Financial
Officer are part-time employees. In addition, we have a number of consulting agreements for clinical development, regulatory affairs, investor relations and business development.

Government Regulation

The United States and other developed countries
extensively regulate the preclinical and clinical testing, manufacturing, labeling, storage, record-keeping, advertising, promotion, export, marketing and distribution of drugs and biologic products. The United States Food and Drug Administration,
under the Federal Food, Drug, and Cosmetic Act, the Public Health Service Act and other federal statutes and regulations, regulates pharmaceutical and biologic products.

To obtain approval of our product candidates from the FDA, we must, among other requirements, submit data supporting safety and efficacy for the intended indication as well as detailed information on the
manufacture and composition of the product candidate. In most cases, this will require extensive laboratory tests and preclinical and clinical trials. The collection of these data, as well as the preparation of applications for review by the FDA
involve significant time and expense. The FDA also may require post-marketing testing to monitor the safety and efficacy of approved products or place conditions on any approvals that could restrict the therapeutic claims and commercial applications
of these products. Regulatory authorities may withdraw product approvals if we fail to comply with regulatory standards or if we encounter problems at any time following initial marketing of our products.

The first stage of the FDA approval process for a new biologic or drug involves completion of preclinical studies and the submission of
the results of these studies to the FDA. This data, together with proposed clinical protocols, manufacturing information, analytical data and other information submitted to the FDA, in an investigational new drug application (IND), must
become effective before human clinical trials may commence. Preclinical studies generally involve FDA regulated laboratory evaluation of product characteristics and animal studies to assess the efficacy and safety of the product candidate.

After the IND becomes effective, a company may commence human clinical trials. These are typically conducted in three
sequential phases, but the phases may overlap. Phase I trials consist of testing of the product candidate in a small number of patients or healthy volunteers, primarily for safety at one or more doses. Phase I trials in cancer are often conducted
with patients who are not healthy and who have end-stage or metastatic cancer. Phase II trials, in addition to safety, evaluate the efficacy of the product candidate in a patient population somewhat larger than Phase I trials. Phase III trials
typically involve additional testing for safety and clinical efficacy in an expanded population at multiple test sites. A company must submit to the



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FDA a clinical protocol, accompanied by the approval of the Institutional Review Boards at the institutions participating in the trials, prior to commencement of each clinical trial.

To obtain FDA marketing authorization, a company must submit to the FDA the results of the preclinical and clinical testing, together
with, among other things, detailed information on the manufacture and composition of the product candidate, in the form of a new drug application (NDA) or, in the case of a biologic, like dendritic cell-based vaccines for neurological
disorders, a biologics license application (BLA).

The amount of time taken by the FDA for approval of an NDA or
BLA will depend upon a number of factors, including whether the product candidate has received priority review, the quality of the submission and studies presented, the potential contribution that the compound will make in improving the treatment of
the disease in question, and the workload at the FDA. The FDA has committed to reviewing standard BLAs in 10 months and priority BLAs in six months, but the actual time it takes to review any BLA that we may file could be substantially longer.

The FDA may, during its review of an NDA or BLA, ask for additional test data that may require the conduct of additional
clinical trials. If the FDA does ultimately approve the product candidate for marketing, it may require post-marketing testing to monitor the safety and effectiveness of the product. The FDA also may in some circumstances impose restrictions on the
use of the product, which may be difficult and expensive to administer and may require prior approval of promotional materials.

The FDA may, in some cases, confer upon an investigational product the status of a fast track product. A fast track product is defined as
a new drug or biologic intended for the treatment of a serious or life-threatening condition that demonstrates the potential to address unmet medical needs for this condition. The FDA can base approval of an NDA or BLA for a fast track product on an
effect on a surrogate endpoint, or on another endpoint that is reasonably likely to predict clinical benefit. If a preliminary review of clinical data suggests that a fast track product may be effective, the FDA may initiate review of entire
sections of a marketing application for a fast track product before the sponsor completes the application.

We will also be
subject to a variety of regulations governing clinical trials and sales of our products outside the United States. Whether or not FDA approval has been obtained, approval of a product candidate by the comparable regulatory authorities of foreign
countries and regions must be obtained prior to the commencement of marketing the product in those countries. The approval process varies from one regulatory authority to another and the time may be longer or shorter than that required for FDA
approval. In the European Union, Canada and Australia, regulatory requirements and approval processes are similar, in principle, to those in the United States.

Before approving a BLA, the FDA will inspect the facilities at which the product is manufactured and will not approve the product unless the manufacturing facilities are in compliance with the FDAs
cGMP, which are regulations that govern the manufacture, holding and distribution of a product. Manufacturers of biologics also must comply with the FDAs general biological product standards. Following approval, the FDA periodically inspects
drug and biologic manufacturing facilities to ensure continued compliance with the good manufacturing practices regulations. We must ensure that any third-party manufacturers continue to comply with those requirements. Failure to comply with these
requirements subjects the manufacturer to possible legal or regulatory action, such as suspension of manufacturing or recall or seizure of product. Adverse patient experiences with the product must be reported to the FDA and could result in the
imposition of marketing restrictions through labeling changes or market removal. Product approvals may be withdrawn if compliance with regulatory requirements is not maintained or if problems concerning safety or efficacy of the product occur
following approval.

The labeling, advertising, promotion, marketing and distribution of a drug or biologic product also must
be in compliance with FDA and Federal Trade Commission, requirements, which include, among others, standards and regulations for off-label promotion, industry sponsored scientific and educational activities, promotional activities involving the
internet, and direct-to-consumer advertising. We also will be subject to a variety of federal, state and local regulations relating to the use, handling, storage and disposal of hazardous materials, including chemicals and radioactive and biological
materials. In addition, we will be subject to



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various laws and regulations governing laboratory practices and the experimental use of animals. In each of these areas, as above, the FDA has broad regulatory and enforcement powers, including
the ability to levy fines and civil penalties, suspend or delay issuance of product approvals, seize or recall products, and deny or withdraw approvals.

We also will be subject to federal regulation by the Occupational Safety and Health Administration and the Environmental Protection Agency and to regulation under the Toxic Substances Control Act, the
Resource Conservation and Recovery Act and other federal and state regulatory statutes, and may in the future be subject to other federal, state or local regulations.

Research and Development

Research and development expenditures for the
years ended December 31, 2009 and December 31, 2010 were $962,526 and $2,292,630, respectively.



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GLOSSARY OF TERMS



|                               |  |                                                                                                                                                                                                                                                                                                                                                                                                                                        
|------------------------------ |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Antibody:                      |  | any of a large body of proteins normally present in the body or produced in response to an antigen that it neutralizes, thus producing an immune response.                                                                                                                                                                                                                                                                             
|                               | 
|Antigen:                       |  | any substance that when introduced into the body can stimulate the production of antibodies and combine specifically with them.                                                                                                                                                                                                                                                                                                        
|                               | 
|Cancer Stem Cell:              |  | cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types
found in a particular cancer sample.                                                                                                                                                                                                               
|                               | 
|Cellular differentiation:      |  | the process by which a cell becomes specialized in order to perform a specific function.                                                                                                                                                                                                                                                                                                                                               
|                               | 
|Cytokine:                      |  | any of a class of immunoregulatory proteins (such as interleukin, tumor necrosis factor, and interferon) that are released by cells of the immune system and act as intercellular
mediators in the generation of an immune response. Also called chemokine.                                                                                                                                                                            
|                               | 
|Dendritic cell:                |  | a highly specialized white blood cell found in the skin, mucosa and lymphoid tissues that initiates a primary immune response by activating lymphocytes and secreting
cytokines.                                                                                                                                                                                                                                                       
|                               | 
|DNA:                           |  | a nucleic acid that carries the genetic information in the cell and is capable of self-replication and synthesis of RNA, which determines protein synthesis and the transmission of
genetic information.                                                                                                                                                                                                                               
|                               | 
|Epitope:                       |  | a localized region on the surface of an antigen that is capable of eliciting an immune response and of combining with a specific antibody to counter that response.                                                                                                                                                                                                                                                                    
|                               | 
|Glioblastoma multiforme (GBM): |  | the most common and most aggressive type of primary brain tumor in humans                                                                                                                                                                                                                                                                                                                                                              
|                               | 
|Immunogenic:                   |  | capable of inducing an immune response.                                                                                                                                                                                                                                                                                                                                                                                                
|                               | 
|Lymphocyte:                    |  | any of various white blood cells, including B cells and T cells, that function in the bodys immune system by recognizing and deactivating antigens. B cells act by
stimulating the production of antibodies. T cells contain receptors on their cell surfaces that are capable of recognizing and binding to specific antigens. Lymphocytes are found in the lymph nodes and spleen and circulate continuously in the
blood and lymph.
|                               | 
|Lysate:                        |  | the cellular debris and fluid produced by the disintegration of a cell resulting from the destruction of its membrane by a chemical substance, especially an antibody or
enzyme.                                                                                                                                                                                                                                                       
|                               | 
|Peptide:                       |  | a compound containing two or more amino acids in which the carboxyl group of one acid is linked to the amino group of the other                                                                                                                                                                                                                                                                                                        
|                               | 
|Stem cell:                     |  | an unspecified cell that upon division replaces its own numbers and also gives rise to cells that differentiate further into one or more specialized cell type.                                                                                                                                                                                                                                                                        
|                               | 
|T cell:                        |  | any of several closely related lymphocytes, developed in the thymus, which circulate in the blood and lymph and orchestrate the immune systems response to infected or
malignant cells.                                                                                                                                                                                                                                               



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|Item 1A. | Risk Factors.
|-------- | -------------

The
risks described below may not be the only ones relating to our company. Additional risks that we currently believe are immaterial may also impair our business operations. Our business, financial conditions and future prospects and the trading price
of our common stock could be harmed as a result of any of these risks. Investors should also refer to the other information contained or incorporated by reference in this Annual Report on Form 10-K for the year ended December 31, 2010,
including our financial statements and related notes, and our other filings from time to time with the Securities and Exchange Commission.

Risks Related To Our Business

We are a development-stage company subject to all
of the risks and uncertainties of a new business, including the risk that we may never market any products or generate revenues.

We are a development-stage company that has only recently commenced any significant research and development activity. There is no assurance that we will be able to satisfactorily develop or market any of
our current or proposed product candidates or that those product candidates will generate revenues or that any revenues generated will be sufficient for us to become profitable or thereafter maintain profitability. Only one of our product candidates
has been clinically tested in an early stage trial. We have not generated any recurring revenues to date, and we do not expect to generate any such revenues for a number of years.

Our cell-based vaccine technologies are our primary platform technologies, and our commercial prospects will be heavily dependent on the
outcome of the contemplated clinical trials for our current lead vaccine product candidate (ICT-107). We have only three full-time employees, including our President and Chief Executive Officer and our Vice-President  Product Development and
Manufacturing, have limited resources and may not possess the ability to successfully overcome many of the risks and uncertainties frequently encountered by early stage companies involved in the new and rapidly evolving field of biotechnology in
general and cancer immunotherapies and monoclonal antibodies in particular. You must consider that we may not be able to:



| |  |  | obtain additional financial resources necessary to develop, test, manufacture and market our vaccine product candidates, our monoclonal antibody
product candidates or any future product candidates;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | engage corporate partners to assist in developing, testing, manufacturing and marketing our vaccine product candidates, our monoclonal antibody product
candidates or any future product candidates;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | satisfy the requirements of acceptable pre-clinical and clinical trial protocols, including timely patient enrollment;
| | - |  | ----------------------------------------------------------------------------------------------------------------------



| |  |  | establish and demonstrate or satisfactorily complete the research to demonstrate at various stages the pre-clinical and clinical efficacy and safety of
our vaccine product candidates, our monoclonal antibody product candidates or any future product candidates; and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | market our vaccine product candidates, our monoclonal antibody product candidates or any future product candidates to achieve acceptance and use by the
medical community and patients in general and produce revenues.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We have a history of losses, expect future losses and
cannot assure you that we will ever become or remain profitable.

With the exception of a one-time licensing fee payment
that we previously received in connection with our entering into a research and license option agreement covering one of our monoclonal antibody product candidates with a third party who did not subsequently exercise that option, we have not
generated any revenues and have incurred operating losses since our inception, and we expect to continue to incur operating losses for the foreseeable future. There is no assurance that we will be able to develop or market products in



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the future that will generate revenues or that any revenues generated will be sufficient for us to become profitable or thereafter maintain profitability. In the event that our operating losses
are greater than anticipated or continue for longer than anticipated, we will need to raise significant additional capital sooner, or in greater amounts, than otherwise anticipated in order to be able to continue development of our present or future
product candidates and maintain our operations.

We will need to obtain significant additional capital, which additional funding may dilute
our existing stockholders.

We believe that our existing cash balances will be sufficient to fund our currently planned
level of operations for at least the next twelve months. We will need significant funding to carry out all of our development work on our vaccine product candidates, our monoclonal antibody product candidates and future product candidates and to
expand the scope of our operations (including seeking to employ additional support personnel on a full-time basis). If we are unable to obtain sufficient capital on a timely basis, the development of our current or any future product candidates is
likely to be delayed, and we could be forced to reduce the scope of our research and development projects or otherwise limit or terminate our operations altogether.

In December 2009, we entered into an agreement with Socius Capital under which Socius Capital has agreed to purchase from time to time an aggregate of up to $10 million of our preferred stock and sold
$4 million of these shares to them in May 2010. However, Socius Capitals obligation to purchase the remaining shares of our preferred stock is subject to our satisfying certain conditions at that time. There is no assurance that we will
be able to satisfy those conditions if we wish to sell shares of our preferred stock to Socius Capital or that Socius Capital will have the ability to complete these purchases. In connection with each sale of preferred stock to Socius Capital, a pro
rata portion of a warrant held by an affiliate of Socius Capital to purchase shares of our common stock will become exercisable. Should the Socius Capital affiliate sell substantial amounts of the underlying shares of our common stock, those sales
could have a material adverse effect on the trading market for our common stock and make it impractical for us to make future sales of preferred stock to Socius Capital without substantial dilution to our existing shareholders.

Except for our financing agreement with Socius Capital, we have not identified the sources for the additional financing that we will
require, and we do not have commitments from any third parties to provide this financing. Certain investors may be unwilling to invest in our securities since we are traded on the OTC Bulletin Board and not on a national securities exchange,
particularly if there is only limited trading in our common stock on the OTC Bulletin Board at the time we seek financing. The volume and frequency of such trading has been limited to date. There is no assurance that sufficient funding through a
financing will be available to us at acceptable terms or at all. Any additional funding that we obtain in a financing is likely to reduce the percentage ownership of the company held by our existing securityholders. The amount of this dilution may
be substantially increased if the trading price of our common stock has declined at the time of any financing from its current levels. We may seek SBIR or other government grants to conduct a portion of our planned research and development work in
addition to certain equity financing. Except for one recently awarded grant under a federal tax credit/grant program for pharmaceutical research and development companies and one recently submitted grant application under the Orphan Drug Act, we
have not yet submitted any requests for these grants, the competition for obtaining these grants is intense and there is no assurance that we will secure any grant funding on a timely basis or at all.

Our access to Dr. Yus research laboratory at Cedars-Sinai may be limited.

We are heavily dependent upon Dr. John Yu, both for past research and as we develop our lead vaccine product candidates or any other
or future vaccine product candidates. His laboratory at Cedars-Sinai has been financed in part by Cedars-Sinai (which is the licensor of our cellular-based therapy technology) and the National Institutes of Health (NIH). Cedars-Sinai or
the NIH or other governmental agencies could promulgate new rules and regulations that might interfere with our product development or ownership rights if we wish to access on a contractual basis Dr. Yus laboratory at Cedars-Sinai in
connection with our research and development activities.



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Our current product candidates and any future product candidates will be based on novel technologies and
are inherently risky.

We are subject to the risks of failure inherent in the development of products based on new
technologies. The novel nature of our therapies creates significant challenges in regards to product development and optimization, manufacturing, government regulation, third-party reimbursement and market acceptance. For example, the FDA has
limited experience with cancer stem cell or dendritic cell-based therapeutics and, with the exception of one dendritic cell-based vaccine for the treatment of prostrate cancer, has not yet approved any of these therapeutics for marketing, and the
pathway to regulatory approval for our vaccine product candidates or any future vaccine product candidates may accordingly be more uncertain, complex and lengthy than the pathway for new conventional drugs. The targeting of cancer stem cells as a
potential therapy is a recent development that may not become broadly accepted by scientists or pharmaceutical companies. In addition, the manufacture of biological products, including cancer stem cell or dendritic cell-based vaccines, could be more
complex and difficult, and therefore, these potential challenges may prevent us from developing and commercializing products on a timely or profitable basis or at all.

We may elect to delay or discontinue preclinical studies or clinical trials based on unfavorable results. Any product candidate using a cellular therapeutic technology may fail to:



| |  |  | survive and persist in the desired location;
| | - |  | --------------------------------------------



| |  |  | provide the intended therapeutic benefits;
| | - |  | ------------------------------------------



| |  |  | properly integrate into existing tissue in the desired manner; or
| | - |  | -----------------------------------------------------------------



| |  |  | achieve therapeutic benefits equal to or better than the standard of treatment at the time of testing.
| | - |  | ------------------------------------------------------------------------------------------------------

In addition, our product candidates may cause undesirable side effects. Results of preclinical research with our vaccine product
candidates or any other or future product candidates or clinical results with formulations used in earlier trials that are similar but not identical to our product candidate formulations may not be indicative of the results that will be obtained in
later stages of preclinical or clinical research on our product candidates. In particular, the results generated in our Phase I trial of ICT-107 covered a small number of patients at a single trial site and may not be indicative of the results that
will be obtained in our current multi-center Phase II trial of a new, optimized formulation of ICT-107. If regulatory authorities do not approve our products or if we fail to maintain regulatory compliance, we would be unable to commercialize our
products, and our business and results of operations would be harmed. Furthermore, because cancer stem cell and dendritic cell based products represent new forms of therapy, the marketplace may not accept any products we may develop that utilize
these technologies. If we do succeed in developing products, we will face many potential obstacles, such as the need to obtain regulatory approvals and to develop or obtain manufacturing, marketing and distribution capabilities. In addition, we will
face substantial additional risks, such as product liability claims.

Because of the early stage of development of our vaccine
product candidates, we do not know if we will be able to generate data that will support the filing of a biologics license or new drug application for these product candidates or the FDAs approval thereof. If we experience substantial delays,
we may not have the financial resources to continue development of these product candidates or the development of any of our other or future product candidates. Delays in clinical trials could reduce the commercial viability of our vaccine product
candidates and any other or future product candidates. Delays in patient enrollment may be caused by a number of factors, including patient reluctance to participate in blinded trials where the patient is not assured of receiving the treatment being
tested in the trial.



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We are required to pay substantial royalties under our license agreement with Cedars-Sinai, and we must
meet certain milestones to maintain our license rights.

Under our license agreement with Cedars-Sinai for our
cellular-based therapy technology, we will be required to pay substantial royalties to that institution based on our revenues from sales of our products utilizing this technology, and these royalty payments could adversely affect the overall
profitability for us of any products that we may seek to commercialize. In order to maintain our license rights under the Cedars-Sinai license agreement, we will need to meet certain specified milestones, subject to certain cure provisions, in the
development of our vaccine product candidates and in the raising of funding. There is no assurance that we will be successful in meeting all of the milestones in the future on a timely basis or at all.

Before we can market our vaccine product candidates or any other or future product candidates, we must obtain governmental approval for each of these
product candidates, the application and receipt of which is time-consuming, costly and uncertain.

Our current product
candidates and any future product candidates that we will be developing will require approval of the U.S. Food and Drug Administration (FDA) before they can be marketed in the U.S. Although our focus at this time is primarily on the U.S.
market, in the future similar approvals will need to be obtained from foreign regulatory agencies before we can market our current and proposed product candidates in other countries. The process for filing and obtaining FDA approval to market
therapeutic products is both time-consuming and costly, with no certainty of a successful outcome. The historical failure rate for companies seeking to obtain FDA approval of therapeutic products is high and, with the exception of Dendreon
Corp.s dendritic cell vaccine for the treatment of prostate cancer, no cancer stem cell or dendritic cell-based cancer vaccine has to date been approved by the FDA. This process includes conducting extensive pre-clinical research and clinical
testing, which may take longer and cost more than we initially anticipate due to numerous factors, including without limitation, difficulty in securing appropriate centers to conduct trials, difficulty in enrolling patients in conformity with
required protocols in a timely manner, unexpected adverse reactions by patients in the trials to our proposed product candidates and changes in the FDAs requirements for our testing during the course of that testing.

The FDA may require pre-clinical work for our monoclonal antibody product candidates beyond what we currently plan to conduct, which
could necessitate significant expenditures on our part that we have not budgeted and which could significantly delay the commencement of clinical trials for these product candidates. The formulation of our cancer stem cell vaccine product candidate
needs to be completed and certain animal testing must be successfully completed with this formulation before we can test this product candidate in humans. Our cancer stem cell vaccine product candidate has not been previously tested in patients, and
we may encounter unexpected and adverse immune responses or other side effects in the patients whom we test with this product candidate.

The time required to obtain FDA and other approvals is unpredictable but often can exceed five years following the commencement of clinical trials, depending upon the complexity of the product and
other factors. Any analysis we perform of data from preclinical and clinical activities is subject to confirmation and interpretation by regulatory authorities, which could delay, limit or prevent regulatory approval. We may also encounter
unexpected delays or increased costs due to a variety of reasons, including new government regulations from future legislation or administrative action, or from changes in FDA policy during the period of product development, clinical trials and FDA
regulatory review.

Any delay or failure in our clinical trial program and in obtaining required approvals would have a
material adverse effect on our ability to generate revenues from the particular product. Furthermore, any regulatory approval to market a product may be subject to limitations on the indicated uses for which we may market the product. These
limitations may limit the size of the market for the product.



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Certain of our current product candidates may not be eligible for Orphan Drug status.

The United States and Europe may designate drugs for relatively small patient populations as orphan drugs. Orphan drug designation does
not convey any advantage in, or shorten the duration of, the regulatory review and approval process, but does make the product eligible for orphan drug exclusivity, reduced filing fees and specific tax credits. Generally, if a company receives the
first marketing approval for a product with an orphan drug designation in the clinical indication for which it has such designation, the product is entitled to orphan drug exclusivity. Orphan drug exclusivity means that the FDA will not approve
another application to market the same drug for the same indication, except in limited circumstances, for a period of seven years in the United States. This exclusivity, however, could block the approval of our proposed product candidates if a
competitor obtains marketing approval before us. We have obtained orphan drug status for our dendritic cell vaccine (ICT-107) to treat glioblastoma multiforme and may also seek this status for our cancer stem cell vaccine to treat glioblastoma
multiforme and other diseases if we meet the eligibility criteria. However, even if we obtain orphan drug exclusivity for any of our proposed product candidates, we may not be able to maintain it. For example, if a competitive product is shown to be
clinically superior to our product, any orphan drug exclusivity we have will not block the approval of such competitive product.

Fast
Track designation for development of our vaccine product candidates or any other potential product candidate may not lead to a faster development or regulatory review or approval process, and it does not increase the likelihood that our product
candidates will receive marketing approval.

If a drug is intended for the treatment of a serious or life-threatening
condition and the drug demonstrates the potential to address unmet medical needs for this condition, the drug sponsor may apply for FDA Fast Track designation for a particular indication. Marketing applications filed by sponsors of products in Fast
Track development may qualify for priority review under the policies and procedures offered by the FDA, but the Fast Track designation does not assure any such qualification or ultimate marketing approval by the FDA. Receipt of Fast Track
designation may not result in a faster development process, review or approval compared to drugs considered for approval under conventional FDA procedures. In addition, the FDA may withdraw any Fast Track designation at any time. We may seek Fast
Track designation for our vaccine product candidates or any other product candidates, but there is no assurance that the FDA will grant this status to any of our proposed product candidates.

Because our current product candidates represent and our other future potential product candidates will represent novel approaches to the treatment of disease, there are many uncertainties regarding
the development, the market acceptance, third-party reimbursement coverage and the commercial potential of our product candidates.

There is no assurance that the approaches offered by our current product candidates or any future product candidates will gain broad acceptance among doctors or patients or that governmental agencies or
third-party medical insurers will be willing to provide reimbursement coverage for proposed product candidates. Moreover, we do not have internal marketing data research resources and are not certain of and have not attempted to independently verify
the potential size of the commercial markets for our current product candidates or any future product candidates. Since our current product candidates and any future product candidates will represent new approaches to treating various conditions, it
may be difficult, in any event, to accurately estimate the potential revenues from these product candidates. We may spend large amounts of money trying to obtain approval for these product candidates, and never succeed in doing so. In addition,
these product candidates may not demonstrate in large sets of patients the pharmacological properties ascribed to them in the laboratory studies or smaller groups of patients, and they may interact with human biological systems in unforeseen,
ineffective or even harmful ways either before or after they are approved to be marketed. We do not yet have sufficient information to reliably estimate what it will cost to commercially manufacture our current product candidates or any future
product candidates, and the actual cost to manufacture these products could materially and adversely affect the commercial viability of these products. Certain of our cell-based vaccine product candidates may be formulated with cells harvested and
processed from individual target patients, which could limit the target patient population for these vaccines and could require complex and costly manufacturing processes to produce these vaccines on a commercial basis. As a



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result, we may never succeed in developing a marketable product. If we do not successfully develop and commercialize products based upon our approach, we will not become profitable, which would
materially and adversely affect the value of our common stock.

Other factors that are presently unknown to us that we believe
will materially affect market acceptance of our current product candidates or any future product candidates include:



| |  |  | the timing of our receipt of any marketing approvals, the terms of any approvals and the countries in which approvals are obtained;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------



| |  |  | the safety, efficacy and ease of administration;
| | - |  | ------------------------------------------------



| |  |  | the availability of government and third-party payor reimbursement;
| | - |  | -------------------------------------------------------------------



| |  |  | the pricing of our product candidates, particularly as compared to alternative treatments; and
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | the availability of alternative effective forms of treatments, at that time, for the diseases that the product candidates we are developing are
intended to treat.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------

Adverse publicity regarding cellular therapies could impact our business.

Although we are not utilizing embryonic stem cells, adverse publicity due to the ethical and social controversies surrounding the use of
such cells or any adverse reported side effects from any stem cell, dendritic or other cell therapy clinical trials or to the failure of such trials to demonstrate that these therapies are efficacious could materially and adversely affect our
ability to raise capital or recruit managerial or scientific personnel or obtain research grants.

As an early stage small company that
will be competing against numerous large, established companies that have substantially greater financial, technical, manufacturing, marketing, distribution and other resources than we have, we will be at a significant competitive disadvantage.

The pharmaceutical and biopharmaceutical industry is characterized by intense competition and rapid and significant
technological changes and advancements. Many companies, research institutions and universities are doing research and development work in a number of areas similar to those that we focus on that could lead to the development of new products which
could compete with and be superior to our product candidates.

Most of the companies with which we compete have substantially
greater financial, technical, research, manufacturing, marketing, distribution and other resources than those of ours. A number of these companies may have or may develop technologies for developing products for treating various diseases, including
brain cancers, that could prove to be superior to ours. We expect technological developments in the pharmaceutical and biopharmaceutical and related fields to occur at a rapid rate, and we believe competition will intensify as advances in these
fields are made. Accordingly, we will be required to continue to devote substantial resources and efforts to research and development activities in order to potentially achieve and maintain a competitive position in this field. Products that we
develop may become obsolete before we are able to market them or to recover all or any portion of our research and development expenses. We will be competing with respect to our products with companies that have significantly more experience and
expertise in undertaking preclinical testing and human clinical trials with new or improved therapeutic products and obtaining regulatory approvals of such products. A number of these companies already market and may be in advanced phases of
clinical testing of various drugs that will or may compete with our current product candidates or other future potential product candidates. Our competitors may develop or commercialize products more rapidly than we do or with significant advantages
over any products we develop. Our competitors may therefore be more successful in commercializing their products than we are, which could adversely affect our competitive position and business.



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In addition to larger pharmaceutical or biopharmaceutical companies that may develop
different competing technologies or technologies within the cellular and stem cell field, we will be competing with a number of smaller biotechnology companies that are focused on cellular therapy and cancer vaccine technologies, which may include
among others Dendreon, Northwest Biotherapeutics, Antigenics, Celldex Therapeutics, NeuralStem, Geron, NeuroNova, ReNeuron, Stemcells, Inc., Advanced Cell Technology and Osiris Therapeutics. Dendreon has received FDA marketing approval for a
prostate cancer vaccine utilizing dendritic cells, Northwest Biotherapeutics is developing a dendritic cell-based vaccine for treating brain tumors, and Celldex Therapeutics has recently completed a Phase II clinical trial to treat glioblastoma with
their cancer vaccine. Other existing and new companies that may enter the field may also be developing vaccines of this type.

Drugs targeting cancer stem cells is a new emerging field, and a number of companies are developing products that are in various stages
of clinical or preclinical development. We will be competing with these companies, which may have more resources than we have. This list may include among others ChemGenex, GlaxoSmithKline, Geron, Stemline Therapeutics, OncoMed Pharmaceuticals,
Raven and Arius Research. In addition, a number of academic and research centers are doing research in this area which may be commercialized by new or existing companies.

A number of monoclonal antibody products currently are being marketed for the treatment of cancer, including Rituxan®, Herceptin®, Compath®, Avastin®, Erbitux®, Vectibix®, Zevatin®, and Bexxar®, and numerous other monoclonal antibody based products are under development for the treatment of cancer. Accordingly, our monoclonal antibody products, if marketed,
can be expected to compete with a number of monoclonal antibody products (as well as other products for the treatment of cancer) that are well established and marketed by substantial organizations.

Colleges, universities, governmental agencies and other public and private research organizations are becoming more active in seeking
patent protection and licensing arrangements to collect royalties for use of technologies that they have developed, some of which may be directly competitive with our lead product candidate or any future product candidates. The governments of a
number of foreign countries are aggressively investing in cellular therapy research and promoting such research by public and private institutions within those countries. These domestic and foreign institutions and governmental agencies, along with
pharmaceutical and specialized biotechnology companies, also can be expected to compete with us in recruiting qualified scientific personnel.

We will need to outsource and rely on third parties for the clinical development and manufacture, sales and marketing of our current product
candidates or any future product candidates, and our future success will be dependent on the timeliness and effectiveness of the efforts of these third parties.

We do not have the required financial and human resources to carry out on our own all the pre-clinical and clinical development for our vaccine product candidates or any other or future product
candidates, and do not have the capability and resources to manufacture, market or sell our current product candidates or any future product candidates. Vaccines are often administered with one or more adjuvants, which if necessary we will have to
procure from a third-party source. We will need to rely on a firm with expertise in producing a humanized form of our monoclonal antibody product candidates. Our business model calls for the outsourcing of the clinical and other development and
manufacturing, sales and marketing of our product candidates in order to reduce our capital and infrastructure costs as a means of potentially improving our financial position. We currently are seeking a partner or licensee to be responsible for the
early stage development of our monoclonal antibody product candidates. Since we do not have any significant efficacy data for these product candidates, it will be more difficult for us to obtain partners or licensees on attractive terms or at all at
this stage. Accordingly, we will seek to enter, at the appropriate time, into agreements with other companies that can assist us and provide certain capabilities that we do not possess. Even if we do succeed in securing these alliances, we may not
be able to maintain them if, for example, development results are disappointing or approval of a product is delayed or sales of an approved product are below expectations. Furthermore, any delay in entering into agreements could delay the
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reduce their competitiveness even if they reach the market. Any such delay related to our agreements could adversely affect our business.

If any party to which we have outsourced certain functions fails to perform its obligations under agreements with us, the development and commercialization of our lead product candidate and any future
product candidates could be delayed or terminated.

To the extent that we rely on third-party individuals or other
companies to manage the day-to-day conduct of our clinical trials or to manufacture, sell or market our current product candidates or any future product candidates, we will be dependent on the timeliness and effectiveness of their efforts. If a
clinical research management organization that we might utilize is unable to allocate sufficient qualified personnel to our studies or if the work performed by it does not fully satisfy the rigorous requirements of the FDA, we may encounter
substantial delays and increased costs in completing our clinical trials. If a firm producing humanized forms of our monoclonal antibody product candidates or a manufacturer of the raw material or finished product for our clinical trials is unable
to meet our time schedules or cost parameters, the timing of our clinical trials and development of our product candidates may be adversely affected. Any manufacturer that we select may encounter difficulties in scaling-up the manufacture of new
products in commercial quantities, including problems involving product yields, product stability or shelf life, quality control, adequacy of control procedures and policies, compliance with FDA regulations and the need for further FDA approval of
any new manufacturing processes and facilities. The manufacture of clinical supplies for studies and commercial quantities of our current product candidates and any future product candidates are likely to be inherently more difficult and costly than
typical chemical pharmaceuticals. This could delay commercialization of any of our product candidates or reduce the profitability of these candidates for us. If any of these occur, the development and commercialization of our product candidates
could be delayed, curtailed or terminated because we may not have sufficient financial resources or capabilities to continue such development and commercialization on our own.

If we or our manufacturers or service providers fail to comply with regulatory laws and regulations, we or they could be subject to enforcement actions, which could affect our ability to market and
sell our vaccine product candidates and any other or future product candidates and may harm our reputation.

If we or our
collaborators, manufacturers or service providers fail to comply with applicable federal, state or foreign laws or regulations, we could be subject to enforcement actions, which could affect our ability to develop, market and sell our current
product candidates or any future product candidates under development successfully and could harm our reputation and lead to reduced or non-acceptance of our proposed product candidates by the market. Even technical recommendations or evidence by
the FDA through letters, site visits, and overall recommendations to academia or biotechnology companies may make the manufacturing of a clinical product extremely labor intensive or expensive, making the product candidate no longer viable to
manufacture in a cost efficient manner. The very nature of the product may make the product candidate not commercially viable. The required testing of the product candidate may make that candidate no longer commercially viable. The conduct of
clinical trials may be critiqued by the FDA, or a clinical trial sites Institutional Review Board or Institutional Biosafety Committee; which may delay or make impossible clinical testing of a product candidate. The Data Safety Monitoring
Committee for a clinical trial established by us may stop a trial or deem a product candidate unsafe to continue testing. This may have significant negative repercussions on the value of the product candidate and may have negative repercussions on
the company and on the shareholders.

Even if we obtain regulatory approvals, our products will be subject to ongoing regulatory review.

Following any initial regulatory approval of any products we may develop, we will also be subject to continuing
regulatory review, including the review of adverse drug experiences and clinical results that are reported after our products are made commercially available. This would include results from any post-marketing tests or vigilance required as a
condition of approval. The manufacturer and manufacturing facilities we use to make any of our products will also be subject to periodic review and inspection by the FDA. The



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discovery of any previously unknown problems with the product, manufacturer or facility may result in restrictions on the product or manufacturer or facility, including withdrawal of the product
from the market. We do not have, and currently do not intend to develop, the ability to manufacture material for our clinical trials or on a commercial scale. Reliance on third-party manufacturers entails risks, including the continuation of a
contractual or other relationship with the third-party manufacturer, and reliance on the third-party manufacturer for regulatory compliance. Our product promotion and advertising also will be subject to regulatory requirements and continuing FDA
review.

The potential ramifications are far-reaching if there are areas identified as out of compliance by regulatory
agencies, including, but not limited to, significant financial penalties, manufacturing and clinical trial consent decrees, commercialization restrictions or other restrictions and litigation.

Our patents may not protect the proprietorship of our products.

Our ability to compete successfully will depend significantly on our ability to defend patents that may have issued, obtain new patents, protect trade secrets and operate without infringing the
proprietary rights of others or others infringing on our proprietary rights. Although Cedars-Sinai as our licensor has filed applications relative to our cancer vaccine technology, we are responsible going forward to prosecute these patent
applications. We do not currently own or have licensed rights to any issued patents covering our cancer vaccine technology, and there is no guarantee that these patent applications will lead to issued patents.

Issuance of patents based upon the various patent applications licensed from Cedars-Sinai will depend upon the U.S. and foreign patent
agencies being able to determine that the claims made in these applications were not already publicly known or were not obvious from prior published patents and literature, including the extensive previous vaccine work performed and published by
Dr. John Yu and other researchers at Cedars-Sinai. We have recently filed a provisional patent application covering our cancer stem cell vaccine product candidate. Another patent application that we licensed from Cedars-Sinai and that we have
been pursuing was rejected by the U.S. Patent and Trademark Office based on prior art. This patent application covers the treatment of brain and other cancers by a combination of a dendritic cell-based vaccine and chemotherapy. We are seeking patent
protection for our dendritic cell-based vaccine product candidate primarily through our licensed multiple antigen patent application. We are not dependent on any of the claims in the combination therapy application being granted in order to complete
the development of or to commercialize either of our cancer vaccine product candidates. We may in the future elect to abandon one of more of our pending patent applications that do not provide significant coverage for the product candidates or
technologies that we have focused on for strategic purposes.

Even if we are able to obtain patent protection for our vaccine
product candidates or any of our other or future product candidates, there is no guarantee that the coverage of these patents or the existing patents we own covering our monoclonal antibody based technology will be sufficiently broad to protect us
from competitors or that we will be able to enforce our patents against potential infringement by third parties. Patent litigation is expensive, and we may not be able to afford the costs. We may not become aware on a timely basis that products we
are developing or marketing infringe the rights of others, nor may we be able to detect unauthorized use or take appropriate and timely steps to enforce our own intellectual property rights. Protecting our intellectual property rights may also
consume significant management time and resources.

Dr. John Yu, a co-inventor of our cellular-based therapy technology
who serves as our Chairman of the Board, is employed by Cedars-Sinai, which may assert that future intellectual property generated by Dr. Yu belongs to that institution rather than to us, and we may be required to seek a license from
Cedars-Sinai for any such rights. We acquired our monoclonal antibody related technology from Molecular Discoveries, but third parties who previously employed that companys lead scientist could potentially assert ownership claims to the
technology. We do not have any issued patents or patent applications covering DIAAD and may not be able to protect this technology through any trade secrets that we may hold or future patents, if any, that we may seek to obtain.



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Nondisclosure agreements with employees and third parties may not adequately prevent disclosure of trade
secrets and other proprietary information.

In order to protect our proprietary technology and processes, we will also
rely in part on nondisclosure agreements with our employees, licensing partners, consultants, agents and other organizations to which we disclose our proprietary information. These agreements may not effectively prevent disclosure of confidential
information, may be limited as to their term, and may not provide an adequate remedy in the event of unauthorized disclosure of confidential information. In addition, others may independently discover trade secrets and proprietary information, and
in such cases we could not assert any trade secret rights against such party. Costly and time-consuming litigation could be necessary to enforce and determine the scope of our proprietary rights, and failure to obtain or maintain trade secret
protection could adversely affect our competitive business position. Since we will rely on trade secrets and nondisclosure agreements, in addition to patents, to protect some of our intellectual property, there is a risk that third parties may
obtain and improperly utilize our proprietary information to our competitive disadvantage. We may not be able to detect unauthorized use or take appropriate and timely steps to enforce our intellectual property rights.

The manufacture, use or sale of our current product candidates or any future product candidates may infringe on the patent rights of others, and we
may be forced to litigate if an intellectual property dispute arises.

Should third parties patent specific cells,
systems, receptors, monoclonal antibodies or other items that we are seeking to utilize in our development activities, we may be forced to license rights from these parties or abandon our development activities if we are unable to secure these
rights on attractive terms or at all. In light of the large number of companies and institutions engaged in research and development in the cellular therapy and monoclonal antibody fields, we anticipate that many parties will be seeking patent
rights for many cellular or monoclonal antibody based technologies and that licensing and cross licensing of these rights among various competitors may arise. Our dendritic cell-based vaccine product candidate utilizes six antigens for which we will
be required to obtain licenses from one or more other parties before we can commercialize this product candidate. There is no assurance that we will be able to obtain all of the licenses that we may need on attractive terms or at all, which could
result in our having to reformulate or abandon this product candidate. In addition, Cedars-Sinai has previously granted another institution rights to the use of certain peptide materials that we may seek to incorporate into one or more of our
cellular-based therapy product candidates. We may be required to obtain a license from that other institution if we wish to use these materials. If we are unable to obtain this license, we would be required to develop vaccine products without the
potential enhanced benefits that could be provided by these materials.

If we infringe or are alleged to have infringed
another partys patent rights, we may be required to defend an infringement action or challenge the validity of the patents in court. Patent litigation is costly and time consuming. We may not have sufficient resources to bring these actions to
a successful conclusion. In addition, if we do not obtain a license, do not successfully defend an infringement action or are unable to have infringed patents declared invalid, we may:



| |  |  | incur substantial monetary damages;
| | - |  | -----------------------------------



| |  |  | encounter significant delays in marketing our current product candidates or any future product candidates;
| | - |  | ----------------------------------------------------------------------------------------------------------



| |  |  | be unable to conduct or participate in the manufacture, use or sale of product candidates or methods of treatment requiring licenses;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------



| |  |  | lose patent protection for our inventions and products; or
| | - |  | ----------------------------------------------------------



| |  |  | find our patents are unenforceable, invalid, or have a reduced scope of protection.
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Parties making such claims may be able to obtain injunctive relief that could effectively
block our ability to further develop or commercialize our current product candidates or any future product candidates in the United States and abroad and could result in the award of substantial damages. Defense of any lawsuit or failure to obtain
any such license could substantially harm us. Litigation, regardless of outcome, could result in substantial cost to and a diversion of efforts by us.

We will be dependent on our key personnel, and the loss of one or more of our key personnel would materially and adversely affect our business and prospects.

Except for our President and Chief Executive Officer and our Vice President  Product Development and Manufacturing, we do not have
any full-time management personnel. We are dependent on our officers and directors for their scientific or managerial skills, including Dr. John Yu, our Chairman of the Board, and Dr. Manish Singh, our President and Chief Executive
Officer. However, these individuals (with the exception of Dr. Singh and our Vice President  Product Development and Manufacturing) are associated with us on a part-time basis only. We do not currently maintain key man life insurance on
Drs. Yu and Singh. The terms of the current employment agreement for Dr. Singh and the agreement for Dr. Yu have expired and they have continued to serve as our President and Chief Executive Officer and Chief Scientific Officer,
respectively, under the terms of the foregoing agreements pending the negotiation of new agreements. Although we anticipate concluding these new agreements in the near future, there can be no assurance that we will be successful in entering into
these agreements on satisfactory terms or at all. Our employment contract with Dr. Singh and our agreement with Dr. Yu under which he serves as our Chief Scientific Officer permit them to terminate providing their services to us without
cause. The loss of the services of either Dr. Singh or Dr. Yu would materially and adversely affect our business.

As we retain additional full-time senior personnel, our overhead expenses for salaries and related items will increase substantially from
current levels. Competition for such personnel is intense, and there is no assurance that we will be able to attract or retain qualified senior personnel and our failure to do so could have an adverse effect on our ability to implement our business
plan.

The market success of our current product candidates and any future product candidates will be dependent in part upon third-party
reimbursement policies that have not yet been established for our product candidates.

Our ability to successfully
commercialize and penetrate the market for our current product candidates and any future product candidates is likely to depend significantly on the availability of reimbursement for our lead product candidate or any other or future product
candidates from third-party payers, such as governmental agencies, private insurers and private health plans. Even if we are successful in bringing a proposed product candidate to the market, these product candidates may not be considered
cost-effective, and the amount reimbursed for our products may be insufficient to allow us to sell any of our products on a competitive basis. We cannot predict whether levels of reimbursement for our product candidates, if any, will be high enough
to allow the price of our product candidates to include a reasonable profit margin. Even with FDA approval, third-party payers may deny reimbursement if the payer determines that our particular product candidates are unnecessary, inappropriate or
not cost effective. If patients are not entitled to receive reimbursements similar to reimbursements for competing products which currently are reimbursable, they may be unwilling to use our product candidates since they will have to pay for the
unreimbursed amounts. The reimbursement status of newly approved health care products is highly uncertain. If levels of reimbursement are decreased in the future, the demand for our lead proposed product candidate and any future product candidates
could diminish or our ability to sell our products on a profitable basis could be adversely affected.

We believe that the
efforts of governments and third-party payors to contain or reduce the cost of healthcare will continue to affect the business and financial condition of pharmaceutical and biopharmaceutical companies. Comprehensive health care reform legislation
that was enacted in 2010 could adversely affect our business and financial condition. Among other provisions, the legislation provides that a biosimilar product may be approved by the FDA on the basis of analytical tests and certain
clinical studies demonstrating that such product is highly similar to an existing, approved product and that switching between an existing product



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and the biosimilar product will not result in diminished safety or efficacy. This abbreviated regulatory approval process may result in increased competition if we are able to bring a
biopharmaceutical product to market. The legislation also includes more stringent compliance programs for companies in various sectors of the life sciences industry with which we may need to comply and enhanced penalties for non-compliance with the
new health care regulations. Complying with new regulations may divert management resources, and inadvertent failure to comply with new regulations may result in penalties being imposed on us.

Some states and localities have established drug importation programs for their citizens, and federal drug import legislation has been
introduced in Congress. The Medicare Prescription Drug Plan legislation, which became law in December 2003, required the Secretary of Health and Human Services to promulgate regulations for drug reimportation from Canada into the United States under
some circumstances, including when the drugs are sold at a lower price than in the United States. The Secretary, however, retained the discretion not to implement a drug reimportation plan if he finds that the benefits do not outweigh the costs, and
has so far declined to approve a reimportation plan. Proponents of drug reimportation may attempt to pass legislation that would directly allow reimportation under certain circumstances. Legislation or regulations allowing the reimportation of
drugs, if enacted, could decrease the price we receive for any products that we may develop and adversely affect our future revenues and prospects for profitability.

A number of legislative and regulatory proposals to change the healthcare system in the United States and other major healthcare markets have been proposed in recent years. These proposals have included
prescription drug benefit legislation recently enacted in the United States and healthcare reform legislation recently enacted by certain states. Further federal and state legislative and regulatory developments are possible, and we expect ongoing
initiatives in the United States to increase pressure on drug pricing. Such reforms could have an adverse effect on anticipated revenues from any products that we may successfully develop.

We may be subject to product liability and other claims that could have a material negative effect on our operations and on our financial condition.

The development and sale of medical products in general, and vaccines in particular, expose us to the risk of significant damages from
product liability and other claims. Product liability claims could delay or prevent completion of our clinical development programs. If we succeed in marketing our current lead products candidate or any future product candidates, such claims could
result in an FDA investigation of the safety and effectiveness of our products or our marketing programs, and potentially a recall of our products or more serious enforcement action, or limitations on the indications for which they may be used, or
suspension or withdrawal of approval. We plan to obtain and maintain product liability insurance for coverage of our clinical trial activities and obtained this coverage for the recently completed and current clinical trials of our dendritic
cell-based vaccine product candidate. There is no assurance that we will be able to secure such insurance in the amounts we are seeking or at all for any of the future trials for our current product candidates or any future product candidates. We
intend to obtain coverage for our products when they enter the marketplace (as well as requiring the manufacturers of our products to maintain insurance), but we do not know if insurance will be available to us at acceptable costs or at all. The
costs for many forms of liability insurance have risen substantially in recent years and the costs for insuring a vaccine type product may be higher than other pharmaceutical products, and such costs may continue to increase in the future, which
could materially impact our costs for clinical or product liability insurance. If the cost is too high, we will have to self-insure, and we may have inadequate financial resources to pay the costs of any claims. A successful claim in excess of our
product liability coverage could have a material adverse effect on our business, financial condition and results of operations.

We may
encounter delays and difficulties in the development of technologies or operations of any other businesses we may acquire.

We may, from time to time, acquire technologies or businesses that are complimentary to our existing technologies or operations or that
we otherwise believe offer an attractive opportunity for us in the future. We may encounter various types of unanticipated difficulties in connection with developing these technologies or



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operating these businesses; the risk of these occurring potentially being greater if these technologies or businesses are not directly related to any existing technology of operations. Any such
difficulties could have a material adverse effect on our financial performance and condition.

Risks Related to Our
Securities

Our stock may be traded infrequently and in low volumes, so you may be unable to sell your shares at or near the quoted
bid prices if you need to sell your shares.

The shares of our common stock may trade infrequently and in low volumes on
the OTC Bulletin Board, meaning that the number of persons interested in purchasing our common shares at or near bid prices at any given time may be relatively small or non-existent. This situation may be attributable to a number of factors,
including the fact that we are a small early stage company which is relatively unknown to stock analysts, stock brokers, institutional investors and others in the investment community who can generate or influence sales volume, and that even if we
came to the attention of such institutionally oriented persons, they tend to be risk-averse in this environment and would be reluctant to follow an early stage company such as ours or purchase or recommend the purchase of our shares until such time
as we became more seasoned and viable. As a consequence, there may be periods of several days or more when trading activity in our shares is minimal or non-existent, as compared to a seasoned issuer which has a large and steady volume of trading
activity that will generally support continuous sales without an adverse effect on share price. We cannot give you any assurance that a broader or more active public trading market for our common shares will develop or be sustained. Due to these
conditions, we can give you no assurance that you will be able to sell your shares at or near bid prices or at all if you need money or otherwise desire to liquidate your shares. As a result, investors could lose all or part of their investment.

You may have difficulty selling our shares because they are deemed penny stocks.

Since our common stock is not listed on a national securities exchange, if the trading price of our common stock remains below $5.00 per
share, trading in our common stock will be subject to the requirements of certain rules promulgated under the Exchange Act, which require additional disclosure by broker-dealers in connection with any trades involving a stock defined as a penny
stock (generally, any non-national securities exchange equity security that has a market price of less than $5.00 per share, subject to certain exceptions). Such rules require the delivery, prior to any penny stock transaction, of a disclosure
schedule explaining the penny stock market and the risks associated therewith and impose various sales practice requirements on broker-dealers who sell penny stocks to persons other than established customers and accredited investors (generally
defined as an investor with a net worth in excess of $1,000,000 or annual income exceeding $200,000 individually or $300,000 together with a spouse). For these types of transactions, the broker-dealer must make a special suitability determination
for the purchaser and have received the purchasers written consent to the transaction prior to the sale. The broker-dealer also must disclose the commissions payable to the broker-dealer, current bid and offer quotations for the penny stock
and, if the broker-dealer is the sole market-maker, the broker-dealer must disclose this fact and the broker-dealers presumed control over the market. Such information must be provided to the customer orally or in writing before or with the
written confirmation of trade sent to the customer. Monthly statements must be sent disclosing recent price information for the penny stock held in the account and information on the limited market in penny stocks. The additional burdens imposed
upon broker-dealers by such requirements could discourage broker-dealers from effecting transactions in our common stock, which could severely limit the market liquidity of the common stock and the ability of holders of the common stock to sell
their shares.

Our existing directors, executive officers and principal stockholders hold a substantial amount of our common stock and may
be able to prevent other stockholders from influencing significant corporate decisions.

As of March 1, 2011, our
directors and executive officers beneficially owned approximately 25% of our outstanding common stock. Dr. John Yu also currently is entitled to serve as a director and to designate two of our other directors. These stockholders, if they act
together, and Dr. Yu, through his right to name three



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of our directors, may be able to direct the outcome of matters, including the election of our directors and other corporate actions such as:



| |  |  | our merger with or into another company;
| | - |  | ----------------------------------------



| |  |  | a sale of substantially all of our assets; and
| | - |  | ----------------------------------------------



| |  |  | amendments to our certificate of incorporation.
| | - |  | -----------------------------------------------

The decisions of these stockholders may conflict with our interests or those of our other stockholders.

Potential conflicts of interest could arise for certain members of our management team in the performance of their services for us.

Dr. John Yu, our Chairman of the Board, and Dr. Keith Black, the Chairman of our Scientific Advisory Board, are full-time
employees of Cedars-Sinai, which owns shares of our common stock and where we plan to conduct certain research and development work, including clinical trials of our vaccine product candidates. Potential conflicts of interest could arise as a
result, including for Dr. Yu and Dr. Black in performing services for us and for Cedars-Sinai, in establishing the terms under which Cedars-Sinai performs work for us, and in Cedars-Sinai conducting the research. Dr. Yu and other
scientists associated with Dr. Yu at Cedars-Sinai may perform research in the field of brain tumors that is sponsored by other third parties. We will not acquire any interest in the intellectual property generated by this research, including
several clinical trials with dendritic cell based vaccines that have been completed or are planned to be initiated. These studies may compete for patients to be enrolled in clinical trials with our current or future clinical trials.

Substantial sales of our common stock could cause our common stock price to fall.

There are currently 23,505,856 outstanding shares of our common stock and another 13,629,428 shares of our common stock issuable upon
exercise of currently exercisable options or warrants that are eligible to be sold pursuant to Rule 144 or currently effective registration statements. We have also agreed to register the 5,219,768 shares of our common stock that were issued in
connection with the private placement that we completed in February 2011 as well as the 2,609,898 shares to investors and 208,791 shares to placement agents of our common stock currently issuable upon exercise of the warrants that were issued in
that private placement. The possibility that substantial amounts of our common stock may be sold in the public market may adversely affect prevailing market prices for our common stock and could impair our ability to raise capital through the sale
of our equity securities.

Our securities are quoted on the OTC Bulletin Board, which may limit the liquidity and price of our securities
more than if our securities were quoted or listed on or a national securities exchange.

Our securities are currently
quoted on the OTC Bulletin Board, an NASD-sponsored and operated inter-dealer automated quotation system for equity securities not listed on a national securities exchange. Quotation of our securities on the OTC Bulletin Board may limit the
liquidity and price of our securities more than if our securities were quoted or listed on a national securities exchange. Some investors may perceive our securities to be less attractive because they are traded in the over-the-counter market. In
addition, as an OTC Bulletin Board listed company, we do not attract the extensive analyst coverage that accompanies companies listed on a national securities exchange. Further, institutional and other investors may have investment guidelines that
restrict or prohibit investing in securities traded in the over-the-counter market. These factors may have an adverse impact on the trading and price of our securities.

The market price of our stock may be adversely affected by market volatility.

The market price of our common stock is likely to be volatile and could fluctuate widely in response to many factors, including:



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| |  |  | announcements of the results of clinical trials by us or our competitors;
| | - |  | -------------------------------------------------------------------------



| |  |  | developments with respect to patents or proprietary rights;
| | - |  | -----------------------------------------------------------



| |  |  | announcements of technological innovations by us or our competitors;
| | - |  | --------------------------------------------------------------------



| |  |  | announcements of new products or new contracts by us or our competitors;
| | - |  | ------------------------------------------------------------------------



| |  |  | actual or anticipated variations in our operating results due to the level of development expenses and other factors;
| | - |  | ---------------------------------------------------------------------------------------------------------------------



| |  |  | changes in financial estimates by securities analysts and whether our earnings meet or exceed such estimates;
| | - |  | -------------------------------------------------------------------------------------------------------------



| |  |  | conditions and trends in the pharmaceutical and other industries;
| | - |  | -----------------------------------------------------------------



| |  |  | new accounting standards;
| | - |  | -------------------------



| |  |  | general economic, political and market conditions and other factors; and
| | - |  | ------------------------------------------------------------------------



| |  |  | the occurrence of any of the risks described in this report.
| | - |  | ------------------------------------------------------------



|Item 1B. | Unresolved Staff Comments.
|-------- | --------------------------

Not applicable.



|Item 2. | Properties.
|------- | -----------

We currently
maintain our corporate office in Woodland Hills, California under a month-to-month lease at a monthly rental rate of $3,493. We do not lease or own any other real property.



|Item 3. | Legal Proceedings.
|------- | ------------------

We
are not a party to any material legal proceedings. We may occasionally become subject to legal proceedings and claims that arise in the ordinary course of our business. It is impossible for us to predict with any certainty the outcome of any
disputes that may arise, and we cannot predict whether any liability arising from claims and litigation will be material in relation to our consolidated financial position or results of operations.



|Item 4. | (Removed and Reserved).
|------- | -----------------------

PART II



|Item 5. | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities.
|------- | -------------------------------------------------------------------------------------------------------------

Market Information

Our
common stock has been traded on the OTC Bulletin Board over-the-counter market since December 7, 2006, under the symbol IMUC. The following price information reflects inter-dealer prices, without retail mark-up, mark-down or
commission and may not represent actual transactions:



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|                   |  |      |      |  |     |  |      | 
|------------------ |  | ---- | ---- |  | --- |  | ---- | 
|Quarter Ended      |  | High |      |  | Low | 
|March 31, 2009     |  |      | 0.35 |  |     |  | 0.15 | 
|June 30, 2009      |  |      | 0.59 |  |     |  | 0.22 | 
|September 30, 2009 |  |      | 1.38 |  |     |  | 0.28 | 
|December 31, 2009  |  |      | 1.22 |  |     |  | 0.61 | 
|March 31, 2010     |  |      | 1.10 |  |     |  | 0.82 | 
|June 30, 2010      |  |      | 2.44 |  |     |  | 0.97 | 
|September 30, 2010 |  |      | 1.18 |  |     |  | 0.84 | 
|December 31, 2010  |  |      | 1.58 |  |     |  | 0.87 | 

Stockholders

As of March 1, 2011, there were approximately 259 holders of record of our common stock, not including any persons who hold their
stock in street name.

Dividend Policy

We have not paid any dividends on our common stock to date and do not anticipate that we will pay dividends in the foreseeable future. Any payment of cash dividends on our common stock in the future will
be dependent upon the amount of funds legally available, our earnings, if any, our financial condition, our anticipated capital requirements and other factors that the Board of Directors may think are relevant. However, we currently intend for the
foreseeable future to follow a policy of retaining all of our earnings, if any, to finance the development and expansion of our business and, therefore, do not expect to pay any dividends on our common stock in the foreseeable future.

Issuances of Unregistered Securities; Purchases of Securities

We did not issue any unregistered securities during the three-month period ended December 31, 2010 that were not previously reported in a Current Report on Form 8-K, and we did not repurchase any
securities during that period.

Equity Compensation Plan Information

See Part III, Item 12, Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters, of this Annual
Report on Form 10-K for information regarding securities authorized for issuance under our equity compensation plans.



|Item 6. | Selected Financial Data.
|------- | ------------------------

Not applicable to a smaller reporting company as defined in Item 10(f)(1) of SEC Regulation S-K.



|Item 7. | Managements Discussion and Analysis of Financial Condition and Results of Operations.
|------- | --------------------------------------------------------------------------------------

You should read the information in this Item 7 together with our consolidated financial statements and notes thereto that appear
elsewhere in this Annual Report. This Annual Report contains forward-looking statements that involve risks, uncertainties, and assumptions. Actual results may differ materially from those anticipated in these forward-looking statements as a result
of various factors, including, but not limited to, those presented under Risk Factors included in Item 1.A of Part I and elsewhere in this Annual Report.

Overview

On January 31, 2006, we completed a merger pursuant to which
Spectral Molecular Imaging, Inc. became our wholly owned subsidiary. At the time of the merger, we had virtually no assets or liabilities, and we had not conducted any business operations for several years. In connection with the merger, we changed
our name from Patco Industries, Ltd. to Optical Molecular Imaging, Inc. and replaced our officers and



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directors with those of Spectral Molecular Imaging. Although we acquired Spectral Molecular Imaging in the merger, for accounting purposes the merger was treated as a reverse merger since the
stockholders of Spectral Molecular Imaging acquired a majority of our outstanding shares of common stock and the directors and executive officers of Spectral Molecular Imaging became our directors and executive officers. Accordingly, our financial
statements contained in this Annual Report and the description of our results of operations and financial condition reflect the operations of Spectral Molecular Imaging.

In May 2006, we decided to suspend our research and development activities on Spectral Molecular Imagings spectral imaging technology, and on September 11, 2006, we sold all of the outstanding
capital stock of Spectral Molecular Imaging to Dr. Daniel Farkas, a co-founder of Spectral Molecular Imaging and inventor of its technology.

In November 2006, we acquired an exclusive, worldwide license from Cedars-Sinai Medical Center for certain cellular-based therapy technology that we are developing for the potential treatment of brain
tumors and other forms of cancer and neurodegenerative disorders. We recently completed a Phase I clinical trial of a vaccine product candidate for the treatment of glioblastoma multiforme based on this technology.

In February 2008, we acquired certain monoclonal antibody related technology owned by Molecular Discoveries LLC. This technology consists
of (1) a platform technology referred to by Molecular Discoveries as DIAAD for the potentially rapid discovery of targets (antigens) and monoclonal antibodies for diagnosis and treatment of diverse human diseases and (2) certain monoclonal
antibody candidates for the potential detection and treatment of multiple myeloma, small cell lung, pancreatic and ovarian cancers.

Plan
of Operation

We are a development stage company that is seeking to develop and commercialize new therapeutics to fight
cancer using the immune system.

Since our companys inception on February 25, 2004, we have been primarily engaged
in the acquisition of certain intellectual property, together with the recent clinical testing activities for one of our vaccine product candidates, and have not generated any recurring revenues. As a result, we have incurred operating losses and,
as of December 31, 2010, we had an accumulated deficit of $22,953,788. We expect to incur significant research, development and administrative expenses before any of our products can be launched and recurring revenues, if ever, are generated.

For additional information about our plan of business operation, see the Business section of this Annual Report
included in Item 1 of Part I.

Critical Accounting Policies

Managements discussion and analysis of our financial condition and results of operations are based on our consolidated financial
statements, which have been prepared in accordance with accounting principles generally accepted in the United States. The preparation of these financial statements requires management to make estimates and judgments that affect the reported amounts
of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. On an ongoing basis, management evaluates its estimates, including those related to impairment of long-lived assets, including finite lived
intangible assets, accrued liabilities and certain expenses. We base our estimates on historical experience and on various other assumptions that we believe to be reasonable under the circumstances, the results of which form the basis for making
judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results may differ materially from these estimates under different assumptions or conditions.

Our significant accounting policies are summarized in Note 2 of our financial statements for the period from February 25, 2004
to December 31, 2010. We believe the following critical accounting policies affect our more significant judgments and estimates used in the preparation of our financial statements:



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Development Stage Enterprise

We are a development stage enterprise as defined by FASB ASC Topic 915, Accounting and Reporting by Development Stage
Enterprises. We are devoting substantially all of our present efforts to research and development. All losses accumulated since inception are considered as part of our development stage activities.

Research and Development Costs

Although we believe that our research and development activities and underlying technologies have continuing value, the amount of future benefits to be derived from them is uncertain. Research and
development costs are therefore expensed as incurred rather than capitalized. During the year ended December 31, 2009 and December 31, 2010, we recorded an expense of $962,526 and $2,292,630, respectively, related to research and
development activities.

Stock-Based Compensation

Stock-based compensation expense is estimated as of the grant date based on the fair value of the award and is recognized as expense over
the requisite service period, which generally equals the vesting period, based on the number of awards that are expected to vest. Estimating the fair value for stock options requires judgment, including the expected term of our stock options,
volatility of our stock, expected dividends, risk-free interest rates over the expected term of the options and the expected forfeiture rate. In connection with our performance based programs, we make assumptions principally related to the number of
awards that are expected to vest after assessing the probability that certain performance criteria will be met.

Results of Operations

For the Twelve Months Ended December 31, 2009 and 2010

Revenues

We had $300,000 in revenues during the period for the twelve months ended December 31, 2009 related to a license fee payment we
received under a research and license option agreement regarding our ICT-69 antibody product candidate with the Roche Group and no revenues during the period for the twelve months ended December 31, 2010. We do not expect to generate any
additional operating revenues during 2011.

Expenses

General and administrative expenses for the twelve months ended December 31, 2009 and for the twelve months ended December 31,
2010 were $1,677,421 and $2,035,526, respectively. During 2009 and 2010, the Company accrued $84,667 and $158,750 in bonuses that are contingent on reaching certain clinical development milestones. Research and development expenses for the twelve
months ended December 31, 2009 and for the twelve months ended December 31, 2010 were $962,526 and $2,292,630, respectively. We had $311,700 of non-cash expense for the twelve months ended December 31, 2009, consisting of $308,303 in
stock based compensation and $3,397 in depreciation expense. We had $1,829,724 of non-cash expense for the twelve months ended December 31, 2010, including $1,018,238 in change in warrant liability expense, $807,853 in stock based compensation
and $3,633 in depreciation expense. On November 10, 2010, the Company received a grant under the Patent Protection and Affordable Care Act of 2010. The grant, which totaled $244,479, will be used to fund ongoing projects, including the
continued development of ICT-107 and was recorded as an offset to research and development costs for fiscal year ended December 31, 2010.

We expect the amount of our general and administrative cash expenses in 2011 to be higher than those cash expenses incurred in 2010, primarily due to increased employee compensation and costs associated
with our phase II clinic trial. We estimate that the cost of our research and development work to be approximately $5,000,000 in 2011, and we may incur significant additional research and development expenses should we



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expand our research and development work on additional potential applications for our existing technologies or should we acquire additional technologies from one or more third parties.

Loss

We incurred a net loss of $2,626,205 for the twelve months ended December 31, 2009 and a net loss of $6,150,142 for the twelve months ended December 31, 2010.

For the Twelve Months Ended December 31, 2008 and 2009

Revenues

We had no revenues during the period for the twelve months ended December 31, 2008 and $300,000 in revenues during the period for the
twelve months ended December 31, 2009 related to a license fee payment we received under a research and license option agreement regarding our ICT-69 antibody product candidate with the Roche Group. We do not expect to generate any additional
operating revenues during 2010.

Expenses

General and administrative expenses for the twelve months ended December 31, 2008 and for the twelve months ended December 31, 2009 were $1,366,146 and $1,677,421, respectively. During 2008 and
2009, the Company accrued $34,952 and $84,667 in bonuses that are contingent on reaching certain clinical development milestones. Research and development expenses for the twelve months ended December 31, 2008 and for the twelve months ended
December 31, 2009 were $1,296,772 and $962,526, respectively. We had $1,004,432 of non-cash expense for the twelve months ended December 31, 2008, consisting of $513,357 in stock based compensation, $489,000 paid in common stock for in
process research and development and $2,075 in depreciation expense. We had $311,700 of non-cash expense for the twelve months ended December 31, 2009, including $308,303 in stock based compensation and $3,397 in depreciation expense.

We expect the amount of our general and administrative cash expenses in 2010 to be higher than those cash expenses incurred
in 2009, primarily due to increased employee compensation and costs associated with financing and investor relations activities. We estimate that the cost of our research and development work to be approximately $3,000,000 in 2010, and we may incur
significant additional research and development expenses should we expand our research and development work on additional potential applications for our existing technologies or should we acquire additional technologies from one or more third
parties.

Loss

We incurred a net loss of $3,059,730 for the twelve months ended December 31, 2008 and a net loss of $2,626,205 for the twelve months ended December 31, 2009.

Liquidity and Capital Resources

As of December 31, 2010, we had working capital of $4,896,360, compared to working capital of $1,053,438 as of December 31, 2009.

The estimated cost of completing the development of either of our current vaccine product candidates and of obtaining all required
regulatory approvals to market either of those product candidates is substantially greater than the amount of funds we currently have available. However, we believe that our existing cash balances, together with the $8 million in proceeds, before
offering costs, from our February 2011 private placement and potential proceeds under our preferred stock purchase arrangement with Socius Capital Group, LLC, will be sufficient to fund our currently planned level of operations through at least the
third quarter of 2012, although there is no assurance that such proceeds will be sufficient for this purpose.



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We do not have any bank credit lines. In February 2011, we completed an $8,090,644 private
placement, before commissions and costs, of 5,219,768 units at a price of $1.55 per unit, with each unit consisting of one share of our common stock and a warrant to purchase 0.5 of a share of our common stock at an exercise price of $2.25 per
share. We may also in the future seek to obtain funding through strategic alliances with larger pharmaceutical or biomedical companies. In December 2009, we entered into an agreement with Socius Capital under which Socius Capital has agreed to
purchase our preferred stock from us from time to time with an aggregate of up to $6 million remaining. However, Socius Capitals obligation to purchase shares of our preferred stock is subject to our satisfying certain conditions at that
time. There is no assurance that we will be able to satisfy those conditions if we wish to sell shares of our preferred stock to Socius Capital or that Socius Capital will have ability to complete these purchases. We cannot be sure that we will be
able to obtain any additional funding from either financings or alliances, or that the terms under which we may be able to obtain such funding will be beneficial to us. If we are unsuccessful or only partly successful in our efforts to secure
additional financing, we may find it necessary to suspend or terminate some or all of our product development and other activities.

As of December 31, 2010, we had no long-term debt obligations, no capital lease obligations, no material purchase obligations or other similar long-term liabilities. In addition, we have no financial
guarantees, debt or lease agreements or other arrangements that could trigger a requirement for an early payment or that could change the value of our assets, and we do not engage in trading activities involving non-exchange traded contracts.

Cash Flows

For the Twelve Months Ended December 31, 2009 and 2010

We used $4,253,560 of cash in our operations for the twelve months ended December 31, 2010, compared to $2,151,781 for the twelve
months ended December 31, 2009, as the non-cash portion of our net loss for the 2010 period was $1,829,724 and the non-cash portion of our net loss for the 2009 period was $311,700.

We provided $1,065,331 of cash from our investing activities for the twelve months ended December 31, 2010, consisting of $1,075,903
in sales of certificates of deposit offset by $10,572 in purchases of equipment and $1,923,284 of cash in our investing activities for the twelve months ended December 31, 2009, consisting of $1,924,097 in sales of certificates of deposit
offset by $813 in purchases of equipment.

We received $8,176,652 of cash from financing activities for the twelve months
ended December 31, 2010, consisting of $26,500 from the exercise of stock options, $3,779,158 from sales of preferred stock and $4,370,994 from the sale of common stock and $474,560 of cash from financing activities for the twelve months ended
December 31, 2009, consisting of $11,812 from the exercise of stock options and $462,748 from the exercise of warrants.

For the Twelve Months Ended December 31, 2008 and 2009

We used $2,151,781 of cash in our operations for the twelve months ended December 31, 2009, compared to $1,945,447 for the twelve
months ended December 31, 2008, as the non-cash portion of our net loss for the 2009 period was $311,700 and the non-cash portion of our net loss for the 2008 period was $1,004,432.

We provided $1,923,284 of cash from our investing activities for the twelve months ended December 31, 2009, consisting of $1,924,097
in sales of certificates of deposit offset by $813 in purchases of equipment and $3,010,087 of cash in our investing activities for the twelve months ended December 31, 2008, consisting of $3,000,000 in purchases of certificates of deposit and
$10,087 in purchases of equipment.

We received $474,560 of cash from financing activities for the twelve months ended
December 31, 2009, consisting of $11,812 from the exercise of stock options and $462,748 from the exercise of warrants and no cash from financing activities for the twelve months ended December 31, 2008.



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|Item 7A. | Quantitative and Qualitative Disclosures About Market Risk.
|-------- | -----------------------------------------------------------

Not applicable to a smaller reporting company as defined in Item 10(f)(1) of SEC Regulation S-K.



|Item 8. | Financial Statements and Supplementary Data.
|------- | --------------------------------------------

Our consolidated financial statements and notes thereto and the related report of Stonefield Josephson, Inc. are included in this Annual Report on Form 10-K beginning at page F-1 and are incorporated
herein by reference.



|Item 9. | Changes in and Disagreements with Accountants on Accounting and Financial Disclosure.
|------- | -------------------------------------------------------------------------------------

Not applicable.



|Item 9A. | Controls and Procedures.
|-------- | ------------------------

Evaluation
of Disclosure Controls and Procedures

We maintain disclosure controls and procedures that are designed to ensure that
information required to be disclosed in the reports that we file with the SEC under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SECs rules and forms and that such information is
accumulated and communicated to our management, including our principal executive and financial officers, as appropriate, to allow for timely decisions regarding required disclosure. As required by SEC Rule 15d-15(b), we carried out an evaluation,
under the supervision and with the participation of our management, including our principal executive and financial officers, of the effectiveness of the design and operation of our disclosure controls and procedures as of December 31, 2010,
which is the end of the period covered by this report. Based on the foregoing, our principal executive and financial officers concluded that our disclosure controls and procedures were effective as of December 31, 2010.

Managements Report on Internal Control Over Financial Reporting

Our management is responsible for establishing and maintaining adequate internal control over financial reporting, as defined in Rule 15d-15(f) under the Exchange Act, and for assessing the effectiveness
of internal control over financial reporting.

Internal control over financial reporting is intended to provide reasonable
assurance regarding the reliability of our financial reporting and the preparation of financial statements for external purposes in accordance with accounting principles generally accepted in the United States. Internal control over financial
reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of our assets, (2) provide reasonable assurance
that transactions are recorded as necessary to permit preparation of financial statements in accordance with accounting principles generally accepted in the United States and that our receipts and expenditures are being made only in accordance with
authorizations of our management and directors, and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisitions, use, or disposition of our assets that could have a material effect on our financial
statements.

Management, with the participation of our principal executive and financial officers, conducted an evaluation of
the effectiveness of our internal control over financial reporting, as of December 31, 2010, based on criteria established in Internal ControlIntegrated Framework issued by the Committee of Sponsoring Organizations of the Treadway
Commission (COSO). Based on that evaluation, management concluded that, as of December 31, 2010, our internal control over financial reporting was effective.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject
to the risk that



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controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

Pursuant to applicable law, this annual report is not required to include an attestation report of our independent registered public
accounting firm regarding internal control over financial reporting.

Changes in Internal Control Over Financial Reporting

There was no change in our internal control over financial reporting during the most recent fiscal quarter that materially affected, or is
reasonably likely to materially affect, our internal control over financial reporting.



|Item 9B. | Other Information.
|-------- | ------------------

None.

PART III



|Item 10. | Directors, Executive Officers and Corporate Governance.
|-------- | -------------------------------------------------------

Executive Officers and Directors

The following table sets forth the name,
age and position held by each of our executive officers and directors. Directors are elected for a period of one year and thereafter serve until the next annual meeting at which their successors are duly elected by the stockholders.



|                                    |  |  |  |     |  |  |  |                                                       
|----------------------------------- |  |  |  | --- |  |  |  | ------------------------------------------------------
|Name                                |  |  |  | Age |  |  |  | Position                                              
|John S. Yu, M.D.                    |  |  |  | 47  |  |  |  | Chairman of the Board                                 
|Manish Singh, Ph.D.(4)              |  |  |  | 42  |  |  |  | President, Chief Executive Officer and Director       
|James Bender, Ph.D.                 |  |  |  | 61  |  |  |  | Vice President  Product Development and Manufacturing
|C. Kirk Peacock                     |  |  |  | 42  |  |  |  | Treasurer and Chief Financial Officer                 
|Rahul Singhvi, Sc.D.(1)(2)(3)(4)    |  |  |  | 46  |  |  |  | Lead Director                                         
|Jacqueline Brandwynne(1)(2)         |  |  |  | 73  |  |  |  | Director                                              
|Richard A. Cowell(2)(3)             |  |  |  | 63  |  |  |  | Director                                              
|Navdeep Jaikaria, Ph.D.(1)(2)(3)(4) |  |  |  | 48  |  |  |  | Director                                              



|(1) | Member of our Compensation Committee
|--- | ------------------------------------

|(2) | Member of our Nominating and Corporate Governance Committee
|--- | -----------------------------------------------------------

|(3) | Member of our Audit Committee
|--- | -----------------------------

|(4) | Member of Our Finance Committee
|--- | -------------------------------

Business Experience and Directorships

The following describes the
backgrounds of current executive officers and directors. Our Board of Directors has determined that (1) all of our directors other than Dr. Singh are independent directors as defined in the Nasdaq rules governing members of boards of
directors and (2) the members of our Audit Committee are independent under applicable SEC rules. Under his current right to designate two other members of our Board of Directors, Dr. Yu designated Dr. Robert Martuza in December 2006
and Jacqueline Brandwynne in January 2007 to serve as two of our directors. Dr. Martuza resigned as a director in February 2011.

John S. Yu, M.D., Chairman of the Board

Dr. Yu served as our
Chief Scientific Officer and as a director from November 2006 to January 2007, when he became our Chairman of the Board. He is a member of the full-time faculty in the Department of Neurosurgery at Cedars-Sinai Medical Center. An internationally
renowned neurosurgeon, Dr. Yus clinical focus is on the treatment of malignant and benign brain and spinal tumors. He is also conducting extensive



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research in immune and gene therapy for brain tumors. He has also done extensive research in the use of neural stem cells as delivery vehicles for brain cancers and neurodegenerative diseases. He
was inducted into Castle and Connellys Americas Top Doctors in 2005. Dr. Yu has published articles in a number of prestigious journals, including The Lancet, Cancer Research, Cancer Gene Therapy, Human Gene Therapy, Journal of
Neuroimmunology, Journal of Neurological Science and Journal of Neurosurgery. Dr. Yu earned his bachelors degree in French literature and biological sciences from Stanford University and spent a year at the Sorbonne in Paris studying
French literature. He also pursued a fellowship in immunology at the Institut Pasteur in Paris. He earned his medical degree from Harvard Medical School and masters degree from the Harvard Universitys Department of Genetics. He completed
his neurosurgical residency at Massachusetts General Hospital in Boston. In addition, he was a Neuroscience Fellow at the National Institutes of Mental Health in the Neuroimmunology Unit at Massachusetts General Hospital from 1988 to 1989 and was a
Culpepper Scholar at the Molecular Neurogenetics Unit at that hospital from 1993 to 1995. His other honors include the Preuss Award, Joint Section on Tumors, American Association of Neurological Surgeons and Congress of Neurologic Surgeons in 1995.
He received the Academy Award from the American Academy of Neurological Surgery at its 1996 annual meeting. Other honors include the Young Investigator Award from the Congress of Neurological Surgeons in 2000, the National Brain Tumor Foundation
Grant in 2001, and the Mahaley Clinical Research award from the American Association of Neurological Surgeons in 2005.

Dr. Yu, as a recognized leader in the field of neurosurgery, has extensive knowledge of current therapies and therapies under
development for the treatment of brain tumors and has participated in numerous clinical trials for potential therapies in this field. As our Chief Scientific Officer and the co-inventor of our brain tumor vaccine technologies, Dr. Yu brings to
the Board significant scientific expertise directly relevant to our product research and development activities.

Manish
Singh, Ph.D., President, Chief Executive Officer and Director

Dr. Singh has served as our President, Chief
Executive Officer and as a director since February 2008. Dr. Singh served as a Director at California Technology Ventures, a venture capital firm from June 2003 to December 2007. He managed investments made by that venture capital firm in a
number of medical device and biotechnology companies and served as a board director or board observer for several of the firms portfolio companies. From October 1995 to June 2002, he held various management and scientific positions with
Odysseus Solutions, Cell Genesys, Chiron Corporation and Genetic Therapy, Inc. Dr. Singh has an MBA from UCLA, a Ph.D. in Chemical and Biochemical Engineering from the University of Maryland Baltimore County, an M.S. in Chemical Engineering
from Worcester Polytechnic Institute and a B.S. in Chemical Engineering from the Indian Institute of Technology, Roorkee.

Dr. Singh has had extensive prior experience as both an operating executive and board member in the biotechnology field. He also
brings to the Board extensive knowledge and experience in the area of financing early stage healthcare companies through his prior work in the venture capital field.

James Bender, Vice President  Product Development and Manufacturing

Dr. Bender served as our Vice President  Clinical Development on a part time basis from September 2008 to February 2010 and has served as our Vice President  Product Development and
Manufacturing on a full-time basis since February 2010. From 2002 through 2008 Dr. Bender held various positions at IDM Pharma, most recently as director of product development where he led that companys efforts relating to the
clinical development of a cancer vaccine for the treatment of lung cancer. Prior to that, he held various positions at Nexell Therapeutics relating to the development of therapeutic stem cell and cancer vaccine products. Prior to that,
Dr. Bender spent 10 years with Baxter Healthcare Corporation, eight years with the University of New Mexico School of Medicine and five years with St. Josephs Hospital in Albuquerque, New Mexico. He has over 75 scientific publications, is
an inventor of 11 U.S. patents and holds a Ph.D. degree in immunology from the University of New Mexico and an M.P.H. in laboratory management from the University of Michigan.



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C. Kirk Peacock, Treasurer and Chief Financial Officer

Mr. Peacock has served as our Treasurer and Chief Financial Officer on a part-time basis since January 2006 and previously served in
that capacity from May 2005 until September 2006 for our predecessor company on a part-time basis. He also served on a part-time basis as our interim President from November 2007 to February 2008. Mr. Peacock is a Certified Public Accountant
and previously was Chief Financial Officer with CytRx Corporation, a ribonucleic acid interference and biopharmaceutical company focused on the development and commercialization of high-value human therapeutics from August 2003 through July 2004.
Mr. Peacock has experience as Chief Financial Officer with several start-up companies, including DigitalMed, Inc., a venture-backed subsidiary of Tenet Healthcare, and Ants.Com, Inc., a venture-backed company of Bertelsmann Ventures.
Mr. Peacock was also a manager with a large, international accounting firm for a number of years. Mr. Peacock serves as a director on the Board of Directors and a member of the Audit Committee of Laird Norton Company LLC. Mr. Peacock
is a graduate of Claremont McKenna College.

Rahul Singhvi, Sc.D., Lead Director

Dr. Singhvi has served as a director since June 2010 and as Lead Director since December 2010. He has been with
Novavax, Inc., a biopharmaceutical company focused on developing novel, highly potent recombinant vaccines since 2004 and has served as President, Chief Executive Officer and Director of Novavax since August 2005. Dr. Singhvi was the Senior
Vice President and Chief Operating Officer of Novavax from April 2005 to August 2005 and Vice President - Pharmaceutical Development and Manufacturing Operations from April 2004 to April 2005. For ten years prior to joining Novavax, he served in
various positions with Merck & Co., Inc., culminating as Director of the Merck Manufacturing Division., where he helped develop several vaccines including Zostavax®, the only vaccine on the market to prevent shingles. Dr. Singhvi received his M.S. and Sc.D. degree in Chemical Engineering from the Massachusetts Institute of
Technology. He also holds an M.B.A. from the Wharton School.

Dr. Singhvi currently serves as the President and Chief
Executive Officer of a public biopharmaceutical company and brings to the Board experience and knowledge in the operation and leadership of early stage public healthcare companies. He also has extensive expertise and experience in the development
and manufacturing of vaccines, which may assist the Board in its oversight of our cancer vaccine programs.

Jacqueline
Brandwynne, Director

Ms. Brandwynne has served as a director since January 2007. Since 1981, Ms. Brandwynne
has served as President and CEO of Brandwynne Corporation, which has co-founded and assisted in the development of several healthcare and biotech companies. Ms. Brandwynne is a business strategist with more than 25 years of experience working
with companies such as American Cyanimid, Bristol Myers/Clairol, National Liberty Life, Seagram & Sons and Neutrogena. From 1974 to 1981 she was in charge of developing Citicorps global business strategy. From 2000 to 2006,
Ms. Brandwynne was a director of Microvision, Inc., a public company that develops sophisticated miniature displays. She has served in multiple advisory roles in several administrations, including as an Advisor to the Council of Economic
Advisors, a member of the US Trade Representatives Services Policy Advisory Committee, a negotiator of the North American Trade Agreement, a participant in GATT negotiations and a member of The Committee on Critical Choices for America, and Chair of
an Economic Summit at the White House. She currently serves on the board of the Proteus Venture Biotech Fund and on several non-profit boards, including the Cedars-Sinai Health Systems Board of Governors. Ms. Brandwynne also serves on the Board
of Advisors of Histogen, Inc.

Ms. Brandwynnes extensive involvement with early stage healthcare and biotech
companies provides the Board with valuable expertise in the operation and development of the Company. With an extensive background as a business strategist for major corporations she also assists the Board in its strategic planning activities.



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Mr. Richard A. Cowell, USA, (Ret.), Director

Mr. Richard A. Cowell, USA, (Ret.) has served as a director since June 2007. Mr. Cowell is a Principal at Booz Allen
Hamilton, Inc., where he is involved in advanced concepts, technology experimentation and integration, and establishing new business operations. Prior to joining Booz Allen Hamilton in March 1996, Mr. Cowell served in the United States Army for
25 years. Mr. Cowell serves as a director and Chair of the Audit Committee for Microvision, Inc. He holds a Top Secret security clearance with special accesses based on a special background investigation. Mr. Cowell holds a B.S. degree in
accounting from Ohio State University.

Mr. Cowell brings to the Board both financial and accounting expertise as well as
experience in the handling of Audit Committee matters for a public company. As consultant with a major consulting firm in the fields of technology experimentation and establishing new business operations, he brings to the Board strategic and
business planning experience.

Navdeep Jaikaria, Ph.D., Director

Dr. Jaikaria has served as a director since June 2008. He currently is CEO of SGN Advisors, Inc., an advisory firm that conducts
global biopharmaceutical due diligence for private equity funds and hedge funds as well as companies. Dr. Jaikaria held various positions with Rodman & Renshaw from 2003 until 2008, when he retired as Managing Director, Senior Equity
Research Analyst  Biotechnology. Dr. Jaikaria previously held positions in equity research with Leerink Swann and Mehta Partners from 2000 to 2003 and consulting positions with Merck & Co. and Antigenics, Inc. from 1996 until
1999. Dr. Jaikaria holds a Ph.D. in Cell Biology and Anatomy from New York Medical College, conducted a research fellowship at Rockefeller University and holds a B.S. in Human Biology from All India Institute of Medical Sciences.

As a highly regarded and experienced former healthcare analyst for major healthcare investment banks, Dr. Jaikaria brings to the
Board extensive healthcare industry knowledge in the area of capital raising and investment banking as well as a broad understanding of the healthcare market and competitive conditions.

Committees of the Board

Our Board of Directors has established an Audit
Committee currently consisting of Mr. Cowell, as Chairman, and Drs. Jaikaria and Singhvi.

The Audit Committee
assists the Board of Directors in fulfilling its oversight responsibilities relating to:



| |  |  | the quality and integrity of our financial statements and reports;
| | - |  | ------------------------------------------------------------------



| |  |  | the independent auditors qualifications and independence; and
| | - |  | --------------------------------------------------------------



| |  |  | the performance of our internal audit function and independent auditors.
| | - |  | ------------------------------------------------------------------------

The Audit Committee appoints the independent auditors, reviews with the independent auditors the plans and results of the audit
engagement, approves permitted non-audit services provided by our independent auditors and reviews the independence of the auditors. The Audit Committee currently consists of Mr. Cowell, as Chairman, and Drs. Jaikaria and Singhvi.
Mr. Cowell has been designated as an audit committee financial expert as defined under Item 407(d)(5) of Regulation S-K of the Exchange Act.

Our Board of Directors has established a Compensation Committee currently consisting of Dr. Jaikaria, as Chairman, Ms. Brandwynne, and Dr. Singhvi. The Compensation Committee reviews, and
makes recommendations to the full Board of Directors relating to, the compensation of our officers and directors, including our officers annual salaries and bonuses and the terms and conditions of option grants to our officers and directors
under our stock incentive plan.



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Our Board of Directors has established a Nominating and Corporate Governance Committee
currently consisting of Ms. Brandwynne, as Chairwoman, Mr. Cowell, Dr. Jaikaria and Dr. Singhvi. The Nominating and Corporate Governance Committee develops and recommends corporate governance guidelines to the Board, selects or
recommends for selection nominees to serve on the Board, and oversees the evaluation of the Board and its committees.

Our
Board of Directors has established a Finance Committee currently consisting of Dr. Singhvi, as Chairman, and Dr. Jaikaria and Dr. Singh. The Finance Committee has oversight responsibility for all material financial matters affecting
the Company, including capital management, funding strategy and investing activities related to our financial position and financing activities.

Scientific Advisory Board

We have established a Scientific Advisory Board
(SAB) currently consisting of Dr. Keith Black, as Chairman, Dr. Peter Brooks, Dr. Sherie Morrison, Dr. Cohava Gelber, Dr. George Peoples, Dr. Constantine Ioannides and Dr. Zvi Ram to assist our
management in the areas of expertise of the members of our SAB. We have compensated the members of our SAB from time to time through the grant of options to purchase our stock. In September 2009, we granted a five-year non-qualified option to
purchase 10,000 shares of our common stock to each of four members of our SAB for service as members on the SAB for the coming year at an exercise price of $0.95 per share, with such option to vest quarterly for the one-year period following the
date of grant. In May 2010, we also granted a five-year non-qualified option to purchase 10,000 shares of our common stock to another member of our SAB for services as a member for the coming year at an exercise price of $1.20 per share, with such
option to vest quarterly for the one-year period following the date of grant.

Keith L. Black, M.D.

Dr. Black has served on our Scientific Advisory Board since January 2007. Dr. Black serves as Chairman of the Department of
Neurosurgery and Director of the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center. An internationally renowned neurosurgeon and scientist, Dr. Black joined Cedars-Sinai Medical Center in July 1997 and was awarded the Ruth
and Lawrence Harvey Chair in Neurosciences in November of that year. Prior to joining Cedars-Sinai, Dr. Black served on the University of California, Los Angeles (UCLA) faculty for 10 years where he was a Professor of Neurosurgery. In 1992 he
was awarded the Ruth and Raymond Stotter Chair in the Department of Surgery and was Head of the UCLA Comprehensive Brain Tumor Program.

Dr. Black serves on the editorial boards of Neurological Research, Gene Therapyand Molecular Biology, Neurosurgery Quarterly and Frontiers In Bioscience. He was on the National
Institutes of Healths Board of Scientific Counselors for Neurological Disorders and Stroke and was appointed to the National Advisory Neurological Disorders and Stroke Council of the National Institutes of Health from 2000 to 2004. He was also
selected as a committee member of the California Institute for Regenerative Medicine Independent Citizens Oversight Committee from 2004-2006.

Dr. Black pioneered research on designing ways to open the blood-brain barrier, enabling chemotherapeutic drugs to be delivered directly into the tumor for which he received the Jacob Javits award
from the National Advisory Neurological Disorders and Stroke Council of the National Institutes of Health in June 2000. Other groundbreaking research done by Dr. Black focused on developing a vaccine to enhance the bodys immune response
to brain tumors, use of gene arrays to develop molecular profiles of tumors, the use of optical technology for brain mapping, and the use of focused microwave energy to noninvasively destroy brain tumors.

Dr. Black has published extensively and has five patents issued or pending. Dr. Black was featured on the cover of Time
magazine in the Fall 1997 special edition Heroes of Medicine and was profiled in 1996 on the PBS program, The New Explorers, in an episode called Outsmarting the Brain.



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John Boockvar, M.D.

Dr. Boockvar currently is Co-Director of the Brain and Spinal Tumor Program at Weill Cornell Medical College. Dr. Boockvar heads
the Brain Tumor and Stem Cell Research Laboratory and directs the institutions Brain Tumor Research Group. Dr. Boockvars laboratory interests have focused on studying adult human neural stem cell biology to investigate brain tumor
formation and brain tumor and stem cell migration and survival. Dr. Boockvar served as Editor-in-Chief of the journal Current Stem Cell Research and Therapy and is an editorial board member of the journal Neurosurgery, and Recent Patents on
Anti-Cancer Drug Discovery. He is an ad-hoc reviewer for Neurosurgery, Brain Research and Human Gene Therapy. He is a member of the Executive Committee (2009-2011) of the Joint Section of Brain Tumors of the American Association of Neurological
Surgeons and Congress of Neurological Surgeons. Dr. Boockvar is the principal investigator of new clinical trials using super selective intraarterial infusion techniques for the delivery of novel therapeutics such as Avastin or Cetuximab for
the treatment of malignant brain cancer. Dr. Boockvar received a B.A. and graduated Cum Laude from the University of Pennsylvania. Dr. Boockvar received an M.D. from SUNY Brooklyn-Downstate Medical Center where he graduated Summa Cum Laude
with Distinction in Research. Dr. Boockvar did his surgical internship and neurosurgical residency at the Hospital of the University of Pennsylvania. Dr. Boockvar did specialized NIH/National Cancer Institute supported fellowship training
in Neuro-oncology (Brain and Spinal Tumors) at the University of Pennsylvania Cancer Center.

Peter Brooks, Ph.D.

Dr. Brooks has served on our Scientific Advisory Board since October 2008. Dr. Brooks serves as a Senior
Scientist at the Maine Medical Center Research Institute, where he is focused on studying mechanisms that regulate angiogenesis, tumor growth and metastasis. Prior to joining that Institute, Dr. Brooks served as associate professor and director
of Antiogenesis and Radiation Research at New York University (NYU) School of Medicine. Prior to association with NYU, Dr. Brooks was an assistant professor at the USC School of Medicine, during which time he co-founded Cell Matrix
Incorporated, a biotechnology company focuses on anti-antiogenic drugs targeting cryptic ECM epitopes. Dr. Brooks studies have led to a recent clinical trial to evaluate the effects of D93, a humanized antibody directed to a cryptic
collagen epitope for the treatment of malignant tumors. Dr. Books obtained his Ph.D. in Cell and Developmental Biology from the State University of New York at Stony Brook.

Cohava Gelber, Ph.D.

Dr. Gelber currently serves as the Chief Scientific & Technology Officer of ATCC, a position she has held since 2005. In this capacity she is responsible for a large group of scientists in
numerous disciplines. Prior to joining ATCC, she served as Vice President - Research and Development for MannKind Corp., a public company developing therapeutics for diabetes, cancer and autoimmune diseases. She was responsible at that company for
non clinical development and clinical immune safety of drugs from pre IND through phase III clinical trials. Dr. Gelber received her Ph.D. from the Weizmann Institute, her MBA degree from Cornell University and post doctorate training at
Stanford University. Dr. Gelber has published numerous scientific manuscripts and textbook chapters and is the inventor of 7 granted patents and 49 patent applications. Dr. Gelber is one of the inventors of several monoclonal antibodies
that we are developing, including ICT-69 and ICT-109, and has served as a consultant to our company in the past two years.

Constantine Ioannides, Ph.D.

Dr. Ioannides is a well-known and highly respected cancer immunologist, with over one hundred peer-reviewed articles in the scientific literature. Dr. Ioannidess current primary research
interests are focused specifically on cancer stem cells. Dr. Ioannides has been involved with some of the most important advancements in the field of cancer immunology over the past 20 years and is the co-discoverer of the NeuVaxT (E75)
vaccine. We recently entered into an option agreement with M.D. Anderson Cancer Center for some of the cancer stem cell technologies that were developed at Dr. Ioannidess laboratory.



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Sherie Morrison, Ph.D.

Dr. Morrison is a distinguished professor of Microbiology, Immunology and Molecular Genetics at the University of California, Los
Angeles. Dr. Morrison joined the faculty of UCLA in 1988 and acted as department chair for 10 years. Prior to that, Dr. Morrison served as professor in the Department of Microbiology at Columbia University College of Physicians and
Surgeons, which followed various post-doctoral fellowships at Columbia University, University of California, Berkeley and Albert Einstein College of Medicine. Her long-time research interest has been the functional properties of antibodies and novel
antibody-related proteins, and she is well published in this area. Dr. Morrison holds Ph.D. and B.A. degrees from Stanford University.

George Peoples, M.D.

Dr. Peoples is the Director of the Cancer
Vaccine Development Program and Deputy Director of the United States Military Cancer Institute. Prior to being appointed to that position, Dr. Peoples held positions as Chief of Surgical Oncology at the Walter Reed Army Medical Center and
Director of the Cancer Vaccine Developmental Laboratory. He received his medical degree from the Johns Hopkins School of Medicine prior to receiving surgical training at Harvard Medical Schools Brigham and Womens Hospital, where he was
also a research fellow. In addition to his appointments at some of the militarys most prestigious cancer research institutions, Dr. Peoples has significant research experience in the oncology field, with multiple peer-reviewed
publications to his credit, including co-discovery credits on HER2/neu vaccines and a number of other anti-cancer vaccines from his time at the M.D. Anderson Cancer Center, where he completed training in surgical oncology.

Zvi Ram, M.D.

Dr. Ram serves as the Chairman of the Department of Neurosurgery at Tel Aviv Medical Center in Israel. His emphasis is on brain tumor therapy, pituitary surgery, and technology development projects
with various companies. Dr. Ram is the Chairman of the European Association of Neurosurgical Societies (EANS) Neurooncology Committee, member of the Executive Steering Committees and lead PI for several pharmaceuticals companies conducting
multicenter international phase III clinical studies, scientific advisor for a number of biotechnology groups, and a member of editorial boards and reviewer for leading scientific journals in his areas of expertise. Dr. Ram previously led a
variety of basic and clinical research projects, including leading the first gene therapy trial for patients with brain tumors, at the Surgical Neurology Branch at the National Institutes of Health in Bethesda, MD.

Code of Ethics

Our
Board of Directors has adopted a code of ethics covering all of our executive officers and key employees. A copy of our code of ethics will be furnished without charge to any person upon written request. Requests should be sent to: Secretary,
ImmunoCellular Therapeutics, Ltd., 21900 Burbank Boulevard, Woodland Hills, California 91367.

Section 16(a) Beneficial Ownership
Reporting Compliance

Because we have not registered our common stock under Section 12 of the Exchange Act, our
directors and executive officers and owners of more than ten percent of our common stock are not required to file with the SEC reports under Section 16(a) of the Exchange Act regarding their ownership and changes in ownership of our common
stock.



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##### Table of Contents

|Item 11. | Executive Compensation
|-------- | ----------------------

Compensation
of Executive Officers

The following table sets forth the compensation for services paid in all capacities for the two
fiscal years ended December 31, 2010 to Dr. Manish Singh, who has served as our President and Chief Executive Officer since February 18, 2008, and to C. Kirk Peacock, who served as our Interim President from November 5, 2007 to
February 17, 2008 and who has served as our Chief Financial Officer since May 16, 2005.

Summary Compensation
Table



|                                                                     |  |      |          |  |           |    |                |          |  |   |                |  |  |                    |         |      |                                         |    |               |                                             |  |  |                          |  |  |          |   |  |  |  |   |  |  |    |                | 
|-------------------------------------------------------------------- |  | ---- | -------- |  | --------- | -- | -------------- | -------- |  | - | -------------- |  |  | ------------------ | ------- | ---- | --------------------------------------- | -- | ------------- | ------------------------------------------- |  |  | ------------------------ |  |  | -------- | - |  |  |  | - |  |  | -- | -------------- | 
|Name and Principal Position                                          |  | Year |          |  | Salary($) |    |                | Bonus($) |  |   | StockAwards($) |  |  | OptionAwards($)(6) |         |      | Non-EquityIncentive PlanCompensation($) |    |               | NonqualifiedDeferredCompensationEarnings($) |  |  | All OtherCompensation($) |  |  | Total($) |  
|Manish Singh, Ph.D. President
and Chief Executive Officer            |  |      | 20092010 |  |           | $$ | 243,750293,287 | (1)(2)   |  | $ | 100,000       |  |  |                    |       |      |                                         | $$ | 87,500222,500 | (7)(8)                                      |  |  |                         |  |  |          |  |  |  |  |  |  |  | $$ | 331,250615,787 | 
|James Bender, Vice President  Product Development and Manufacturing |  |      | 2010     |  |           | $  | 155,833        | (3)      |  | $ | 15,000         |  |  |                    |        |      |                                         |    | 73,625        | (9)                                         |  |  |                          |  |  |          |   |  |  |  |   |  |  | $  | 244,458        | 
|C. Kirk Peacock Chief
Financial Officer                              |  |      | 20092010 |  |           | $$ | 80,00076,000   | (4)(5)   |  |   |              |  |  | $                  | 20,390 | (11) |                                         | $  | 15,194       | (10)                                        |  |  |                         |  |  |          |  |  |  |  |  |  |  | $$ | 95,19496,390   | 



|(1) | Includes $16,667 per month for the period from January 1, 2009 through February 17, 2009 and $20,833 from February 18, 2009 through December 31,
2009 for services rendered to us as President and Chief Executive Officer.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Includes $20,833 per month for the period from January 1, 2010 through February 17, 2010 and $25,000 from February 18, 2010 through December 31,
2010 for services rendered to us as President and Chief Executive Officer.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Includes $14,167 per month for the period from February 1, 2010 through December 31, 2010 for services as Vice President  Product Development and
Manufacturing.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------

|(4) | Includes $8,000 per month for the period from January 1, 2009 through April 30, 2009 and $6,000 from May 1, 2009 through December 31, 2009 for
services rendered to us as Chief Financial Officer and Treasurer.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | Includes $6,000 per month for the period from January 1, 2009 through October 31, 2010 and $8,000 per month from November 1, 2010 through
December 31, 2010 for services as Chief Financial Officer and Treasurer.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | This column represents option awards computed in accordance with FASB ASC Topic 718, excluding the effect of estimated forfeitures related to service-based vesting
conditions. For additional information on the valuation assumptions with respect to the option grants, refer to Note 2 of our financial statements in this Annual Report. These amounts do not correspond to the actual value that will be recognized by
the named executives from these awards.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(7) | Includes (i) a seven-year option to purchase 600,000 shares of our common stock granted February 18, 2008 at an exercise price of $1.00 per
share, vesting monthly over a one-year period following the date of grant and (ii) a seven-year option to purchase 300,000 shares of our common stock granted February 18, 2009 at an exercise price of $0.15 per share, vesting monthly over a
one-year period following the date of grant and (iii) a seven-
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | year option to purchase 200,000 shares of our common stock granted February 18, 2009 at an exercise price of $0.15 per share, vesting if the Company achieves during term of the agreement
either (a) a volume weighted average trading price for its common stock of greater than $1.00 for any 30-day period during the term of the agreement on average daily trading volume of at least 10,000 shares, or (b) working capital at the
end of the term of the agreement of at least $5,000,000, for services rendered as President and Chief Executive Officer.
| | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(8) | Includes (i) a seven-year option to purchase 300,000 shares of our common stock granted February 18, 2009 at an exercise price of $0.15 per share, vesting
monthly over a one-year period following the date of grant, (ii) a seven-year option to purchase 360,000 shares of our common stock granted February 18, 2010 at an exercise price of $0.90 per share, vesting monthly over a one-year period
following the date of grant, (iii) a seven-year option to purchase 240,000 shares of our common stock granted February 18, 2010 at an exercise price of $0.90 per share, vesting in certain increments if the Company achieves during term of
the agreement (a) vesting of 30,000 shares for a volume weighted average trading price for its common stock of greater than $1.60 for any 15-day period during the term of the agreement on average daily trading volume of at least 20,000 shares,
or (b) vesting of 90,000 shares for a volume weighted average trading price for its common stock of greater than $2.00 for any 15-day period during the term of the agreement on average daily trading volume of at least 20,000 shares, or
(c) vesting of 30,000 shares for treating the first patient in a phase II clinical trial, or (d) vesting of 90,000 shares if the Corporation completes a financing, a strategic alliance or licensing agreement with upfront licensing payments
to the Corporation or a merger or acquisition that generates at least $5,000,000 of net proceeds, for services rendered as President and Chief Executive Officer.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(9) | Includes (i) a seven-year option to purchase 75,000 shares of our common stock granted February 1, 2010 at an exercise price of $0.90 per share, vesting
monthly over a one-year period following the date of grant, (ii) a seven-year option to purchase 25,000 shares of our common stock granted February 1, 2010 at an exercise price of $0.90 per share, vesting if the Company completes by
September 30, 2010 the tech transfer to a contract manufacturer organization for ICT-107, including without limitation validation/qualification runs, (iii) a seven-year option to purchase 25,000 shares of our common stock granted
February 1, 2010 at an exercise price of $0.90 per share, vesting if the Company completes by December 31, 2010 FDA acceptance of a Phase II clinical trial plan for ICT-107, and (iv) a seven-year option to purchase 25,000 shares of
our common stock granted February 1, 2010 at an exercise price of $0.90 per share, vesting if the Company completes by December 31, 2010 enrollment of the first patient into the Phase II clinical trial for ICT-107, for services as Vice
President  Product Development and Manufacturing.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(10) | Includes (i) a seven-year option to purchase 50,000 shares of our common stock granted October 30, 2008 at an exercise price of $0.30 per share, vesting
monthly over a one-year period following the date of grant, for services rendered as Chief Financial Officer and Treasurer commencing October 30, 2008 and (ii) a seven-year option to purchase 50,000 shares of our common stock granted
October 30, 2009, at an exercise price of $0.80 per share, vesting monthly over a one-year period following the date of grant, for services rendered as Chief Financial Officer and Treasurer commencing October 30, 2009 and (iii) a
seven-year option to purchase 6,000 shares of our common stock granted October 30, 2009, at an exercise price of $0.80 per share, vesting upon the completion of the Companys internal documentation and internal testing necessary to
subsequently complete the Companys Sarbanes-Oxley Section 404 audit.
|---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(11) | Includes 19, 231 shares of restricted common stock, vesting monthly over a five-month period following the date of grant, for services rendered as Chief Financial
Officer and Treasurer.
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Stock Option Grants

The following table sets forth information as of December 31, 2010 concerning unexercised options, unvested stock and equity incentive plan awards for the executive officers named in the Summary
Compensation Table.



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OUTSTANDING EQUITY AWARDS AT YEAR ENDED DECEMBER 31, 2010



|                    |  |                                                               |         |      |                                                                 |  |         |                                                                                       |  |  |                        |  |  |                      |      |  |                                                       |  |          |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|------------------- |  | ------------------------------------------------------------- | ------- | ---- | --------------------------------------------------------------- |  | ------- | ------------------------------------------------------------------------------------- |  |  | ---------------------- |  |  | -------------------- | ---- |  | ----------------------------------------------------- |  | -------- | ---------------------------------------------------------- |  |  | ------------------------------------------------------------------------------------------- |  |  | --------------------------------------------------------------------------------------------------------- |  |  |  |  |  |  |  |  |  | 
|                    |  | Option Awards                                                 |         |      | Stock Awards                                                    | 
|Name                |  | Number ofSecuritiesUnderlyingUnexercisedOptions(#)Exercisable |         |      | Number ofSecuritiesUnderlyingUnexercisedOptions(#)Unexercisable |  |         | EquityIncentivePlanAwards:Number
ofSecuritiesUnderlyingUnexercisedUnearnedOptions (#) |  |  | OptionExercisePrice($) |  |  | OptionExpirationDate |      |  | Number ofShares orUnits ofStock ThatHave NotVested(#) |  |          | MarketValue ofShares orUnits ofStock ThatHave
NotVested($) |  |  | EquityIncentivePlanAwards:Number ofUnearnedShares,Units
orOtherRights ThatHave NotVested(#) |  |  | EquityIncentivePlanAwards:Market orPayoutValue ofUnearnedShares,Units
orOtherRights ThatHave NotVested($) | 
|Manish Singh, Ph.D. |  |                                                               | 700,000 | (1)  |                                                                 |  |         |                                                                                       |  |  |                        |  |  | $                    | 1.00 |  |                                                       |  | 02-17-15 |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 25,000  | (2)  |                                                                 |  |         |                                                                                       |  |  |                        |  |  |                      | 0.27 |  |                                                       |  | 09-28-15 |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 250,000 | (8)  |                                                                 |  | 50,000  | (8)                                                                                   |  |  |                        |  |  |                      | 0.15 |  |                                                       |  | 02-17-16 |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               |         |      |                                                                 |  | 400,000 | (9)                                                                                   |  |  |                        |  |  |                      | 0.15 |  |                                                       |  | 02-17-16 |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 7,846   | (10) |                                                                 |  | 23,538  | (10)                                                                                  |  |  |                        |  |  |                      | 0.95 |  |                                                       |  | 09-13-16 |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|C. Kirk Peacock     |  |                                                               | 50,181  | (3)  |                                                                 |  |        |                                                                                       |  |  |                        |  |  |                      | 0.35 |  |                                                       |  | 05-15-10 |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 25,000  | (4)  |                                                                 |  |        |                                                                                       |  |  |                        |  |  |                      | 1.00 |  |                                                       |  | 10-29-13 |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 50,000  | (5)  |                                                                 |  |        |                                                                                       |  |  |                        |  |  |                      | 1.00 |  |                                                       |  | 10-29-13 |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 50,000  | (6)  |                                                                 |  |        |                                                                                       |  |  |                        |  |  |                      | 1.30 |  |                                                       |  | 10-29-14 |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 50,000  | (7)  |                                                                 |  |         |                                                                                       |  |  |                        |  |  |                      | 0.30 |  |                                                       |  | 10-29-15 |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 50,000  | (11) |                                                                 |  |         |                                                                                       |  |  |                        |  |  |                      | 0.80 |  |                                                       |  | 10-29-16 |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|James Bender        |  |                                                               | 36,000  | (12) |                                                                 |  |         |                                                                                       |  |  |                        |  |  |                      | 0.68 |  |                                                       |  | 8-31-15  |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 15,000  | (13) |                                                                 |  |         |                                                                                       |  |  |                        |  |  |                      | 0.95 |  |                                                       |  | 8-31-16  |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 5,000   | (14) |                                                                 |  | 5,000   | (15)                                                                                  |  |  |                        |  |  |                      | 0.95 |  |                                                       |  | 8-31-16  |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 68,750  | (16) |                                                                 |  | 6,250   | (16)                                                                                  |  |  |                        |  |  |                      | 0.90 |  |                                                       |  | 1-31-17  |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 
|                    |  |                                                               | 50,000  | (17) |                                                                 |  |         |                                                                                       |  |  |                        |  |  |                      | 0.90 |  |                                                       |  | 1-31-17  |                                                            |  |  |                                                                                             |  |  |                                                                                                           |  |  |  |  |  |  |  |  |  | 



|(1) | Vested monthly following grant on February 18, 2008
|--- | ---------------------------------------------------

|(2) | Vested 25% quarterly following grant on September 29, 2008
|--- | ----------------------------------------------------------

|(3) | Vested monthly following grant on May 16, 2005.
|--- | -----------------------------------------------

|(4) | Vested upon grant, October 30, 2006.
|--- | ------------------------------------

|(5) | Vested 25% quarterly following grant on October 30, 2006.
|--- | ---------------------------------------------------------

|(6) | Vested monthly following grant on October 30, 2007.
|--- | ---------------------------------------------------

|(7) | Vested monthly following grant on October 30, 2008.
|--- | ---------------------------------------------------

|(8) | Vested monthly following grant on February 18, 2009 as to 300,000 shares.
|--- | -------------------------------------------------------------------------

|(9) | Vests upon completion of milestones pursuant to contract.
|--- | ---------------------------------------------------------

|(10) | Vests 25% quarterly following grant on September 14, 2009.
|---- | ----------------------------------------------------------

|(11) | Vests monthly following grant on October 30, 2009.
|---- | --------------------------------------------------

|(12) | Vested monthly following grant on September 1, 2008.
|---- | ----------------------------------------------------

|(13) | Vests 3,000 shares monthly following grant on September 1, 2009
|---- | ---------------------------------------------------------------

|(14) | Vested upon achievement of milestone pursuant to contract.
|---- | ----------------------------------------------------------

|(15) | Vests upon completion of milestones pursuant to contract.
|---- | ---------------------------------------------------------

|(16) | Vests monthly following grant on February 1, 2010.
|---- | --------------------------------------------------

|(17) | Vests upon completion of milestones pursuant to contract.
|---- | ---------------------------------------------------------



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Compensation of Directors

The following table sets forth information concerning the compensation paid to each of our non-employee directors during 2010 for their services rendered as directors. The non-employee directors also each
received 10,000 shares of our restricted common stock as part of their annual compensation with such grant to vest 25% on January 4, 2011, 25% on March 27, 2011, 25% on June 27, 2011 and 25% on September 27, 2011. The
compensation of Dr. Singh, who serves as a director and as our President and Chief Executive Officer, is described above in the Summary Compensation Table.

DIRECTOR COMPENSATION FOR FISCAL YEAR 2010



|                      |  |                          |        |  |             |  |   |                    |  |   |                                      |     |  |                                          |   |  |                       |  |   |       |  |  |   |  |  |   |        | 
|--------------------- |  | ------------------------ | ------ |  | ----------- |  | - | ------------------ |  | - | ------------------------------------ | --- |  | ---------------------------------------- | - |  | --------------------- |  | - | ----- |  |  | - |  |  | - | ------ | 
|Name                  |  | FeesEarnedor Paidin Cash |        |  | StockAwards |  |   | OptionAwards(1)(7) |  |   | Non-EquityIncentive PlanCompensation |     |  | NonqualifiedDeferredCompensationEarnings |   |  | All OtherCompensation |  |   | Total | 
|Jacqueline Brandwynne |  | $                        | 20,500 |  |             |  |  |                    |  | $ | 27,900                               | (2) |  |                                          |  |  |                       |  |  |       |  |  |  |  |  | $ | 48,400 | 
|Richard A. Cowell     |  | $                        | 24,500 |  |             |  |  |                    |  | $ | 34,100                               | (3) |  |                                          |  |  |                       |  |  |       |  |  |  |  |  | $ | 58,600 | 
|Navdeep Jaikaria      |  | $                        | 24,250 |  |             |  |  |                    |  | $ | 34,100                               | (4) |  |                                          |  |  |                       |  |  |       |  |  |  |  |  | $ | 58,350 | 
|Robert L. Martuza     |  | $                        | 27,000 |  |             |  |  |                    |  |   |                                     |     |  |                                          |  |  |                       |  |  |       |  |  |  |  |  | $ | 27,000 | 
|Rahul Singhvi         |  | $                        | 13,861 |  |             |  |  |                    |  | $ | 41,900                               | (5) |  |                                          |  |  |                       |  |  |       |  |  |  |  |  | $ | 55,761 | 
|John Yu               |  | $                        | 30,750 |  |             |  |  |                    |  | $ | 31,000                               | (6) |  |                                          |  |  |                       |  |  |       |  |  |  |  |  | $ | 61,750 | 



|(1) | This column represents the aggregate grant date fair value of options awarded computed in accordance with FASB ASC Topic 718, excluding the effect of estimated
forfeitures related to service-based vesting conditions. For additional information on the valuation assumptions with respect to the option grants, refer to Note 2 of our financial statements in this Annual Report. These amounts do not
correspond to the actual value that will be recognized by the named directors from these awards.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | On September 27, 2010 we granted to Ms. Brandwynne a seven-year non-qualified option to purchase 45,000 shares of the Companys common stock at an
exercise price of $0.90 per share, vesting quarterly over a one-year period for her services as a director.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | On September 27, 2010 we granted to Mr. Cowell a seven-year non-qualified option to purchase 55,000 shares of the Companys common stock at an exercise
price of $0.90 per share, vesting quarterly over a one-year period for his services as a director.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(4) | On September 27, 2010 we granted to Dr. Jaikaria a seven-year non-qualified option to purchase 55,000 shares of the Companys common stock at an exercise
price of $0.90 per share, vesting quarterly over a one-year period for his services as a director.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | On September 27, 2010 we granted to Dr. Yu a seven-year non-qualified option to purchase 50,000 shares of the Companys common stock at an exercise price
of $0.90 per share, vesting quarterly over a one-year period for his services as a director.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | As of December 31, 2010, our non-employee directors held vested and unvested options, which they received as compensation for their services as directors, to
purchase the following number of shares of our common stock: Jacqueline Brandwynne  170,401 shares; Richard A. Cowell  218,301 shares; Navdeep Jaikaria  55,000 shares; Robert L. Martuza  137,767 shares; and John Yu 
176,068 shares.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Stock Incentive Plan

We have adopted an equity incentive plan, the 2006 Equity Incentive Plan, as amended (the Equity Plan), pursuant to which we are authorized to grant options, restricted stock and stock
appreciation rights to purchase up to 6,000,000 shares of common stock to our employees, officers, directors, consultants and advisors. Awards under the plan may consist of stock options (both non- qualified options and options intended to qualify
as Incentive Stock Options under Section 422 of the Internal Revenue Code of 1986, as amended), restricted stock awards and stock appreciation rights.



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The Equity Plan is administered by our Board of Directors or a committee appointed by the
Board, which determines the persons to whom awards will be granted, the type of award to be granted, the number of awards to be granted and the specific terms of each grant, including the vesting thereof, subject to the provisions of the plan.

The Equity Plan provides that the exercise price of each incentive stock option may not be less than the fair market value of
our common stock on the date of grant (or 110% of the fair market value in the case of a grantee holding more than 10% of our outstanding common stock). The exercise price of a non-qualified stock option shall be no less than the fair market value
of the common stock on the date of grant. The maximum number of options that may be granted in any fiscal year to any participant is 725,000.

The plan also permits the grant of freestanding stock appreciation rights or in tandem with option awards. The grant price of a stock appreciation right shall be no less than the fair market value of a
share on the date of grant of the stock appreciation right. No stock appreciation right shall be exercisable later than the tenth anniversary of its grant. Upon the exercise of a stock appreciation right, a participant shall be entitled to receive
common stock at a fair market value equal to the benefit to be received by the exercise.

The plan also provides us with the
ability to grant or sell shares of common stock that are subject to certain transferability, forfeiture, repurchase or other restrictions. The type of restriction, the number of shares of restricted stock granted and other such provisions shall be
determined by our Board of Directors or its committee.

Unless otherwise determined by our Board of Directors or its
committee, awards granted under the Equity Plan are not transferable other than by will or by the laws of descent and distribution.

The Equity Plan provides that, except as set forth in an individual award agreement, upon the occurrence of a corporate transaction: (i) our Board of Directors or its committee shall notify each
participant at least 30 days prior to the consummation of the corporate transaction or as soon as may be practicable and (ii) all options and stock appreciation rights shall terminate and all restricted stock shall be forfeited immediately
prior to the consummation of such corporate transaction unless the committee determines otherwise in its sole discretion. A corporate transaction means (i) a liquidation or dissolution of the company; (ii) a merger or
consolidation of the company with or into another corporation or entity (other than a merger with a wholly-owned subsidiary); (iii) a sale of all or substantially all of the assets of the company; or (iv) a purchase or other acquisition of
more than 50% of the outstanding stock of the company by one person or by more than one person acting in concert.

Our Board
of Directors may alter, amend or terminate the plan in any respect at any time, but no alteration, amendment or termination will adversely affect in any material way any award previously granted under the plan, without the written consent of the
participant holding such award.

As of December 31, 2010, there were outstanding options under the Equity Plan to
purchase approximately 3,761,421 shares of our common stock at a weighted average exercise price of approximately $0.78 per share and 61,537 shares of unvested restricted stock. The grants of options and restricted stock under the Equity Plan during
2010 are described below.

In December 2010, we granted 10,000 restricted shares of our common stock to each of five of our
non-employee directors as part of their compensation for services as a director with such shares to vest in four equal installments on January 4, 2011, March 27, 2011, June 27, 2011, and September 27, 2011.

In September 2010, we granted a non-qualified option to purchase shares of common stock to each of our directors for their service
as a director for the one-year period commencing September 27, 2010. Each of the options granted to the directors has a term of seven years, has an exercise price of $0.90 per share, vests in four equal quarterly installments following the date
of grant, and may be exercised within their term during the period the grantee provides services to us and for 24 months after the grantee ceases providing services for any reason other than termination by us for cause. The amounts of the annual
grants were: Jacqueline



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Brandwynne, 45,000 shares; Richard Cowell, 55,000 shares; Dr. Navdeep Jaikaria, 55,000 shares; Dr. Manish Singh, 30,000 shares; Dr. Rahul Singhvi, 55,000 shares and Dr. John
Yu, 65,000 shares.

In June 2010, we granted a non-qualified option to purchase 12,500 shares of common stock at an exercise
price of $1.14 per share to Dr. Rahul Singhvi for his service on our board until the next annual grant, with such option to vest in four equal quarterly installments following the date of grant, and may be exercised within its term during the
period the grantee provides services to us and for 24 months after the grantee ceases providing services for any reason other than termination by us for cause.

In June 2010, we granted a five-year non-qualified option to purchase 10,000 shares of our common stock at an exercise price of $1.10 per share to Dr. John Boockvar for service as a member of our
Scientific Advisory Board, with such option to vest in four equal quarterly installments for the one-year period following the date of grant.

In May 2010, we granted a five-year non-qualified option to purchase 10,000 shares of our common stock at an exercise price of $1.20 per share to Dr. Ram Zvi for service as a member of our Scientific
Advisory Board, with such option to vest in four equal quarterly installments for the one-year period following the date of grant.

In March 2010, we granted a five-year non-qualified option to purchase 150,000 shares of our common stock at an exercise price of $0.90 to Dr. Elma Hawkins for services as Consultant  Clinical
Affairs, with such option to vest as to 100,000 shares in equal monthly installments for one year following the date of grant, and 50,000 shares to vest upon the achievement of certain specified milestones.

In March 2010, we granted a seven-year non-qualified option to purchase 125,000 shares of our common stock at an exercise price of $0.90
to Dr. John Yu for services rendered as our Chief Scientific Officer, with 75,000 shares of such option to vest in four equal quarterly installments following the date of grant and with 50,000 shares of such option to vest in accordance with
the achievement of milestones contained in his employment agreement, and such option may be exercised within its term during the period the grantee provides services to us and for 24 months after the grantee ceases providing services for any reason
other than termination by us for cause.

In February 2010, we granted a seven-year incentive option to purchase 600,000 shares
of our common stock at an exercise price of $0.90 per share to Dr. Manish Singh upon the renewal of his employment as our President and Chief Executive Officer, with 360,000 of the shares to vest at the rate of 30,000 shares per month during
the term of his agreement and with the remaining 240,000 shares to vest in accordance with the achievement of milestones contained in his employment agreement, and such option may be exercised within its term during the period the grantee provides
services to us and for 24 months after the grantee ceases providing services for any reason other than termination by us for cause.

In February 2010, we granted a seven-year non-qualified option to purchase 150,000 shares of our common stock at an exercise price of $0.90 per share to James Bender in accordance with his employment
agreement to serve as our Vice President  Product Development and Manufacturing for a one-year term, with such option to vest at the rate of 6,250 shares per month during the term of the employment agreement and with the remaining 75,000
shares to vest in accordance with the achievement of milestones contained in his employment agreement.

Employment Agreements

John S. Yu, M.D.

Dr. John Yu and the Company entered into an Agreement, dated as of November 17, 2006, and a related Securities Purchase Agreement, dated as of November 17, 2006, Non-qualified Stock Option
Agreement, dated as of November 17, 2006 and Registration Rights Agreement, dated as of November 17, 2006. Under that Agreement, Dr. Yu agreed to serve as our Chief Scientific Officer for an initial one-year term on a part-time basis.
Pursuant to that Agreement, the Company agreed that (i) for so long as Dr. Yu owns



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Company shares or fully vested immediately exercisable options to purchase Company shares totaling at least 2,000,000 shares, the Company will use commercially reasonable efforts to enable
Dr. Yu to continue to serve on its Board of Directors and (ii) for so long as Dr. Yu owns shares of the Companys common stock or fully vested immediately exercisable options to purchase shares of the Companys common stock
totaling at least 4,000,000 shares or at least 5,000,000 shares, the Company will use commercially reasonable efforts to enable Dr. Yu and either one or two, respectively, of his designees to serve on its Board of Directors.

Effective March 1, 2010, the Company entered into an Agreement with Dr. Yu under which he agreed to serve on a part-time basis
as the Companys Chief Scientific Officer for a one-year term. The Agreement provides for an annual base salary of $70,000 and for cash bonuses of $15,000 each if prior to December 31, 2010 (i) the FDA has accepted a Phase II
clinical trial plan for ICT-107 and (ii) a Physicians Investigator IND submission for one of the Companys specified product candidates has been accepted by the FDA. Subsequent to February 28, 2011, Dr. Yu has continued to serve
as the Companys Chief Scientific Officer under the terms of the foregoing Agreement pending the negotiation of a new agreement.

Pursuant to the Agreement, the Company granted to Dr. Yu a seven-year nonqualified stock option under the Companys 2006 Equity Incentive Plan, or a new qualified option plan, to purchase
125,000 shares of the Companys common stock at an exercise price equal to $0.90 per share, which was the closing market price of the common stock on the option grant date. The option grant is subject to the approval by the Companys
stockholders of an increase in the authorized number of shares under the Plan. The option may be exercised during the period that Dr. Yu provides services to the Company and for 24 months after termination for any reason except termination
for cause by the Company, provided that such exercise is within the seven-year term of the option.

The option granted to
Dr. Yu under the Agreement will vest (i) as to 75,000 shares in four equal quarterly installments following the date of grant and (ii) as to the remaining 50,000 shares, 25,000 shares shall each vest upon timely satisfying the two
milestones described above for the payment of cash bonuses to Dr. Yu.

Manish Singh, Ph.D.

Effective February 18, 2009, the Company entered into an Employment Agreement with Dr. Manish Singh (the 2009 Employment
Agreement) pursuant to which Dr. Singh continued to serve on a full-time basis as the Companys President and Chief Executive Officer for a one-year term. The Company was required under the 2009 Employment Agreement to use its
commercially reasonable efforts to have Dr. Singh continue to serve as a member of the Companys Board of Directors during the term of the 2009 Employment Agreement.

The 2009 Employment Agreement provided for an annual base salary of $250,000 and cash bonuses of (1) $50,000 if the Company completed a financing, a strategic alliance or a merger or acquisition that
generates at least $2,500,000 of net proceeds (after commissions) during the term of the agreement; (2) $100,000 if the Company completed a financing, a strategic alliance or a merger or acquisition that generates at least $5,000,000 of net
proceeds (after commissions) during the term of the agreement; or (3) $200,000 if the Company completed a financing, a strategic alliance or a merger or acquisition that generates at least $10,000,000 of net proceeds (after commissions) during
the term of the agreement. The total cash bonus payable would in no event exceed $200,000. Pursuant to the 2009 Employment Agreement, the Company granted Dr. Singh a seven-year non-qualified stock option on February 18, 2009 under the
Equity Plan to purchase 700,000 shares of the Companys common stock at an exercise price of $0.15 per share. The option vests (i) as to 300,000 shares in twelve equal monthly installments of 25,000 shares each over the twelve-month
period from and immediately following the grant date, (ii) as to 200,000 shares if the Company achieved during term of the agreement either (a) a volume weighted average trading price for its common stock of greater than $1.00 for any
30-day period during the term of the agreement on average daily trading volume of at least 10,000 shares, or (b) working capital at the end of the term of the agreement of at least $5,000,000; and (iii) as to 200,000 shares if the Company
achieved during term of the agreement either (a) a volume weighted average trading price for its common stock of greater than $1.50 for any 30-day period during the term of the agreement on average daily trading volume of at least 10,000 shares
or (b) working



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capital at the end of the term of the agreement of at least $8,000,000. The option may be exercised during the period that Dr. Singh provides services to the Company and for 24 months
after termination for any reason except termination for cause by the Company, provided that such exercise is within the seven-year term of the option.

In the event that the Company terminated the 2009 Employment Agreement without cause or did not extend the 2009 Employment Agreement upon its expiration for an additional one-year term or Dr. Singh
terminated the 2009 Employment Agreement due to (1) his principal place of work for the Company being relocated by more than 50 miles, (2) a material change in his duties, (3) a failure by the Company to pay him any of his contractual
compensation, or (4) a constructive termination of Dr. Singh or unlawful harassment or retaliation against him, then the Company upon such termination was required to make a lump sum payment to Dr. Singh equal to six months of his
base annual salary and 50% of the shares covered by his option (or 100% of all such shares if the Company is not the surviving entity in a Corporate Transaction (as defined by the Equity Plan) that had not yet vested would immediately become vested.
In the event the Company completed a merger in which Dr. Singh was offered an executive position with the Company or surviving corporation for at least a one-year term, with an annual base salary of $250,000 and a cash bonus and option
compensation package having an aggregate value of at least $75,000 (as determined in good faith by the Company or surviving corporation), Dr. Singh was not entitled to terminate the 2009 Employment Agreement based on a change in duties and
responsibilities or a location change.

Effective as of February 18, 2010, the Company entered into a new Employment
Agreement with Dr. Manish Singh (the 2010 Employment Agreement) pursuant to which Dr. Singh will continue to serve on a full-time basis as the Companys President and Chief Executive Officer for a one-year term. The
Company is required under the 2010 Employment Agreement to use its commercially reasonable efforts to have Dr. Singh continue to serve as a member of the Companys Board of Directors during the term of the 2010 Employment Agreement. The
2010 Employment Agreement may be extended for an additional one-year period upon the mutual agreement of the Company and Dr. Singh. Subsequent to February 17, 2010, Dr. Singh has continued to serve as the Companys President and
Chief Executive Officer under the terms of the 2010 Employment Agreement pending the negotiation of a new employment agreement.

The 2010 Employment Agreement provides for an annual base salary of $300,000. In addition, provided that Dr. Singh continues to
serve as the Companys President and Chief Executive Officer for the entire one-year term of the 2010 Employment Agreement, the Company will pay Dr. Singh a discretionary cash bonus of up to $50,000 upon completion of the one-year term.

The 2009 Employment Agreement with Dr. Singh provided that Dr. Singh was entitled to receive cash milestone
bonuses, not to exceed an aggregate amount of $200,000, of (1) $50,000 upon the Companys completion of a financing, a strategic alliance or a merger or acquisition generating at least $2,500,000 of net proceeds (after commissions) during
the term of that agreement, (2) $100,000 upon the Companys completion of a financing, a strategic alliance or a merger or acquisition generating at least $5,000,000 of net proceeds (after commissions) during the term of that agreement, or
(3) $200,000 upon the Companys completion of a financing, a strategic alliance or a merger or acquisition generating at least $10,000,000 of net proceeds (after commissions) during the term of that agreement. The 2009 Employment Agreement
also provided that an option granted to Dr. Singh to purchase 200,000 shares of the Companys common stock would vest if the Companys working capital is at least $8,000,000 at the end of the term of that agreement.

The 2010 Employment Agreement amends the 2009 Employment Agreement to provide that the milestones described in the preceding paragraph
may be satisfied by including the net proceeds received by the Company at any time prior to August 17, 2010 from (1) a financing by the Socius Capital Group or (2) any private placement financing that is covered by a signed term sheet
that was entered into by the Company prior to February 18, 2010 or from another source at the same or better terms as contemplated by such signed term sheet. Also, for purposes of determining whether the $8,000,000 working capital milestone in
the preceding paragraph has been satisfied, the 2010 Employment Agreement provides that working capital will be calculated as of the date of the Companys receipt of the proceeds that are being included to satisfy the milestone.



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Pursuant to the 2010 Employment Agreement, the Company granted to Dr. Singh a
seven-year incentive stock option under the Companys 2006 Equity Incentive Plan, or a new qualified option plan, to purchase 600,000 shares of the Companys common stock at an exercise price equal to $0.90 per share, which was the closing
market price of the common stock on the option grant date. The option grant is subject to the approval by the Companys stockholders of an increase in the authorized number of shares under the Plan and an increase in the number of shares that
may be granted to any individual during a twelve-month period. The option may be exercised during the period that Dr. Singh provides services to the Company and for 24 months after termination for any reason except termination for cause by
the Company, provided that such exercise is within the seven-year term of the option.

The option granted to Dr. Singh
under the 2010 Employment Agreement will vest (1) as to 360,000 shares, in twelve equal monthly installments of 30,000 shares each over the twelve-month period from and immediately following the grant date, (2) as to 30,000
shares, if the Company achieves during the term of the that agreement a volume-weighted average trading price for its common stock of greater than $1.60 for any consecutive 15-day trading period during the term of that agreement on average daily
trading volume of at least 20,000 shares, (3) as to 90,000 shares, if the Company achieves during the term of that agreement a volume-weighted average trading price for its common stock of greater than $2.00 for any consecutive 15-day
trading period during the term of that agreement on average daily trading volume of at least 20,000 shares, (4) as to 30,000 shares, upon treating during the term of that agreement the first patient in a Phase II clinical trial, and (5) as
to 90,000 shares, if during the term of the agreement the Company completes a financing, a strategic alliance or a licensing agreement with upfront licensing payments to the Company or a merger or acquisition that generates at least $5,000,000 of
net proceeds (after commissions) for the Company beyond the $10,000,000 achieved by August 17, 2010, with any financing proceeds received by the Company during the first six months of the 2010 Employment Agreement that are used to satisfy
milestones under the 2009 Employment Agreement not being included as proceeds to satisfy the milestones described in this paragraph.

In the event that the Company terminates the 2010 Employment Agreement without cause or does not extend the 2010 Employment Agreement upon its expiration for an additional one-year term, then (1) the
Company upon such termination will be required to make a lump sum payment to Dr. Singh equal to six months of his base annual salary, (2) any stock options granted to Dr. Singh, to the extent vested, will be retained by Dr. Singh
and will be exercisable on the terms described above, and (3) the vesting of an additional number of shares subject to all options granted to Dr. Singh equal to 50% of all shares subject to such options that have not already vested will
immediately accelerate and will be exercisable on the terms described above. If Dr. Singh terminates his employment for good reason as defined in the Employment Agreement, he will receive the severance benefits described in the
preceding sentence, except that 100% of his options will vest if his employment terminates for good reason following a merger or similar corporate transaction in which the Company is not the surviving entity.

James Bender, Ph.D.

Effective February 1, 2010, the Company entered into an Employment Agreement with Dr. James Bender pursuant to which Dr. Bender will serve on a full-time basis as the Companys Vice
President  Product Development and Manufacturing for a one-year term commencing February 1, 2010. Prior to February 1, 2010, Dr. Bender had been serving on a part-time basis as the Companys Vice President  Clinical
Development pursuant to an Agreement dated as of September 1, 2009, as amended on September 14, 2009. Subsequent to January 31, 2011, Dr. Bender has continued to serve as the Companys Vice President  Product
Development and Manufacturing under the terms of the foregoing Employment Agreement pending the negotiation of a new employment agreement.

The Employment Agreement provides for an annual base salary of $170,000. Pursuant to the Employment Agreement, the Company granted to Dr. Bender a seven-year incentive stock option under the
Companys 2006 Equity Incentive Plan to purchase 150,000 shares of the Companys common stock at an exercise price equal to $0.90 per share, which was the closing market price of the common stock on the option grant date. The option grant
is subject to the approval by the Companys stockholders of an increase in the authorized number of shares under the Plan.



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The option granted to Dr. Bender under the Employment Agreement will vest at the rate
of 6,250 shares per month over the term of the Employment Agreement as to 75,000 shares. The option will vest as to the remaining 75,000 shares upon the Companys attainment of the following development milestones, and Dr. Bender will also
be entitled to receive the following cash bonuses upon attainment of these milestones: (1) completion by September 30, 2010 of the technology transfer to a contract manufacturer for the Companys ICT-107 product will result in a
$10,000 cash bonus and the vesting of 25,000 option shares; (2) completion by December 31, 2010 of FDA acceptance of a Phase II clinical trial plan for ICT-107 will result in a $10,000 cash bonus and the vesting of 25,000 option shares;
and (3) completion by December 31, 2010 of the enrollment of the first patient into the Phase II clinical trial for ICT-107 will result in a $10,000 bonus and the vesting of 25,000 option shares.

The Employment Agreement provides that all of the rights and obligations of the Company and Dr. Bender under his prior agreement to
provide services to the Company (including Dr. Benders right to work for another organization) terminated as of January 31, 2010, except that Dr. Benders right under that agreement to receive cash bonuses and the vesting
of options upon the Companys achievement of specified development milestones will remain in effect. The Employment Agreement provides that, except as described in the following sentence, if Dr. Benders employment terminates prior to
the expiration of the one-year term, Dr. Bender will not have any right to receive further compensation under the Employment Agreement other than compensation that was accrued as of his employment termination date. If the Company terminates
Dr. Benders employment without cause as defined in the Employment Agreement, 50% of any unvested options held by Dr. Bender as of the employment termination date will vest, and he will also have the right to receive any
compensation that was accrued as of the employment termination date.

C. Kirk Peacock

Effective October 30, 2008, the Company entered into an Employment Agreement with Mr. Peacock under which he continued to serve
on a part-time basis as the Companys Chief Financial Officer for a one-year term. Under this agreement, Mr. Peacock received a monthly salary of $8,000 and was granted a seven-year non-qualified option to purchase 50,000 shares of the
Companys common stock at a price of $0.30 per share, with such option to vest in equal monthly installments over the one-year term of the agreement, with 50% of any then unvested option shares to become vested if Mr. Peacocks
employment was terminated by the Company without cause and with all vested options to be exercisable for 24 months after termination of Mr. Peacocks employment for any reason other than termination by the Company for cause.

Effective October 30, 2009, the Company entered into a new Employment Agreement with Mr. Peacock under which he
will continue to serve on a part-time basis as the Companys Chief Financial Officer for a one-year term. Under this agreement, Mr. Peacock receives a monthly salary of $6,000 and was granted a seven-year non-qualified option to purchase
56,000 shares of the Companys common stock at a price of $0.80 per share, with 50,000 shares covered by such option to vest in equal monthly installments over the one-year term of the agreement and with 50% of any those then unvested option
shares to become vested if Mr. Peacocks employment is terminated by the Company without cause.

Provided that by
October 29, 2010, all of the Companys internal documentation and internal testing necessary to subsequently complete the Companys Sarbanes-Oxley Section 404 audit has been finished, the Company will pay Mr. Peacock an
additional $6,000 and a further 6,000 of his option shares will become vested. Due to the elimination of the Sarbanes-Oxley Section 404 audit requirement for smaller issuers, this milestone was not met.

Effective October 30, 2010, the Company renewed the Consulting Agreement with Mr. Peacock under which he will continue to serve
on a part-time basis as the Companys Chief Financial Officer for five months. Under this agreement, Mr. Peacock receives a monthly salary of $8,000 and was granted 19,231 shares of restricted common stock, with such shares to vest in
equal monthly installments over the five-month term of the agreement and with 100% of any unearned compensation to become payable and any unvested option shares to become vested if Mr. Peacocks services are terminated by the Company
without cause.

Indemnification of Directors and Officers

Our Amended and Restated Certificate of Incorporation provides that, to the full extent permitted by the Delaware General Corporation Law, no director will be personally liable to us or our stockholders
for or with respect to any acts or omissions in the performance of his or her duties as a director.

Our Amended and Restated
Certificate of Incorporation also provides that each person who is or was or had agreed to become a director or officer, and each such person who is or was serving or who had agreed to



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serve at our request as a director, officer, employee, or agent of another corporation, partnership, joint venture, trust, or other entity, will be indemnified by us to the full extent permitted
by the Delaware General Corporation Law and will be entitled to advancement of expenses in connection therewith. Our Bylaws have similar indemnification provisions.

Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to our directors, officers and controlling persons pursuant to the foregoing provisions, or otherwise,
we have been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.



|Item 12. | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters.
|-------- | -----------------------------------------------------------------------------------------------

The following table sets forth certain information regarding beneficial ownership of our common stock as of March 1, 2011 (a) by
each person known by us to own beneficially 5% or more of any class of our common stock, (b) by each of our executive officers named in the Summary Compensation Table and our directors and (c) by all executive officers and directors of
this company as a group. As of March 1, 2011, there were 28,725,624 shares of our common stock issued and outstanding. Unless otherwise noted, we believe that all persons named in the table have sole voting and investment power with respect to
all the shares beneficially owned by them.



|                                                                                                                                             |  |                             |           |      |                    |  |       |  
|-------------------------------------------------------------------------------------------------------------------------------------------- |  | --------------------------- | --------- | ---- | ------------------ |  | ----- | -
|Name and Address of Beneficial Owner
(1)                                                                                                     |  | SharesBeneficiallyOwned
(2) |           |      | Percentageof Class | 
|John S. Yu, M.D.                                                                                                                             |  |                             | 6,489,492 | (3)  |                    |  | 18.43 | %
|Socius CG II, Ltd.
Socius Capital Group, LLC
Terren S. Peizer Patricia Peizer 11150 Santa Monica Boulevard, Suite 1500 Los Angeles, CA 90025 |  |                             | 3,073,000 | (5)  |                    |  | 9.99  | %
|Donald R. Scifres 2010 Annuity Trust R One First Street, Ste. 14 Los Altos, CA 94022                                                         |  |                             | 1,789,784 | (5)  |                    |  | 6.09  | %
|Keith Black, M.D. 8631 West Third Street, Suite 800E Los Angeles, CA 90048                                                                   |  |                             | 1,400,000 | (3)  |                    |  | 4.65  | %
|Dr. Manish Singh                                                                                                                             |  |                             | 1,725,223 | (7)  |                    |  | 5.79  | %
|James Bender                                                                                                                                 |  |                             | 164,000   | (3)  |                    |  | *     |  
|C. Kirk Peacock                                                                                                                              |  |                             | 174,262   | (8)  |                    |  | *     |  
|Jacqueline Brandwynne                                                                                                                        |  |                             | 267,901   | (9)  |                    |  | *     |  
|Richard A. Cowell                                                                                                                            |  |                             | 195,801   | (10) |                    |  | *     |  
|Navdeep Jaikaria                                                                                                                             |  |                             | 18,750    | (11) |                    |  | *     |  
|Rahul Singhvi                                                                                                                                |  |                             | 26,932    | (12) |                    |  | *     |  
|All executive officers and directors as a group (8 persons)                                                                                  |  |                             | 9,200,128 |      |                    |  | 24.81 | %



|* | Less than 1%.
|- | -------------



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##### Table of Contents

|(1) | Unless otherwise indicated, the address of each of the persons shown is c/o ImmunoCellular Therapeutics, Ltd., 21900 Burbank Boulevard, 3rdFloor, Woodland Hills, California 91367.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Beneficial ownership is determined in accordance with the rules of the Securities and Exchange Commission and generally includes voting or investment power with respect
to securities. Shares of common stock subject to options, warrants and convertible securities currently exercisable or convertible, or exercisable or convertible within 60 days after March 1, 2011, are deemed outstanding, including for purposes
of computing the percentage ownership of the person holding such option, warrant or convertible security, but not for purposes of computing the percentage of any other holder.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | All of the shares shown are subject to options.
|--- | -----------------------------------------------

|(4) | Includes 5,000 shares of our restricted stock and 6,484,492 shares of our common stock issuable upon the exercise of stock options.
|--- | -----------------------------------------------------------------------------------------------------------------------------------

|(5) | Includes 1,025,000 shares owned of record and 2,048,000 shares subject to warrants. Socius CG II, Ltd. holds currently exercisable warrants to exercise up to 2,375,000
shares, but the exercise of these warrants is limited by their terms so that beneficial ownership by Socius CG II, Ltd. shall not exceed at any time 9.99% of our common shares outstanding. The address of Socius CG II, Ltd. is Clarendon House, 2
Church Street, Hamilton HM 11, Bermuda. The address of Socius Capital Group, LLC, Terren S. Peizer and Patricia Peizer is 11150 Santa Monica Boulevard, Suite 1500, Los Angeles, California 90025. Socius Capital Group, LLC, Mr. Peizer and
Mrs. Peizer each disclaims beneficial ownership of the securities described in the first sentence of this note 4, all of which are held of record by Socius CG II, Ltd. Information regarding the entities and individuals described in this note 4
is based upon a Schedule 13G/A filed by such persons with the SEC on February 14, 2011.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Includes 1,107,966 shares owned of record and 681,818 shares of our common stock issuable upon exercise of warrants.
|--- | --------------------------------------------------------------------------------------------------------------------

|(7) | Includes 663,839 shares owned of record and 1,061,384 shares of our common stock issuable upon exercise of options.
|--- | -------------------------------------------------------------------------------------------------------------------

|(8) | Includes 80,031 shares owned of record, 19,231 shares of our restricted stock and 75,000 shares of our common stock issuable upon exercise of options.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------

|(9) | Includes 40,000 shares owned of record, 5,000 shares of our restricted stock and 222,901 shares of our common stock issuable upon exercise of options.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------

|(10) | Includes 5,000 shares of our restricted stock and 190,801 shares of our common stock issuable upon exercise of stock options.
|---- | -----------------------------------------------------------------------------------------------------------------------------

|(11) | Includes 5,000 shares of our restricted stock and 13,750 shares of our common stock issuable upon exercise of stock options.
|---- | ----------------------------------------------------------------------------------------------------------------------------

|(12) | Includes 8,182 shares owned of record, 5,000 shares of our restricted stock and 13,750 shares of our common stock issuable upon exercise of options.
|---- | ----------------------------------------------------------------------------------------------------------------------------------------------------

Equity Compensation Plan Information

The following table summarizes, as of December 31, 2010, (i) the number of shares of our common stock that are issuable under our equity compensation plans upon the exercise of outstanding
options, warrants and other rights, (ii) the weighted-average exercise price of such options, warrants and rights, and (iii) the number of securities remaining available for future issuance under our equity compensation plans.



|                                                       |  |  |  |                                                                                       |            |  |  |  |                                                                          |   |      |  |  |                                                                                                                                       |  |  |           | 
|------------------------------------------------------ |  |  |  | ------------------------------------------------------------------------------------- | ---------- |  |  |  | ------------------------------------------------------------------------ | - | ---- |  |  | ------------------------------------------------------------------------------------------------------------------------------------- |  |  | --------- | 
|Plan Category                                          |  |  |  | Number ofsecurities to beissued uponexercise ofoutstandingoptions, warrantsand rights |            |  |  |  | Weighted-averageexercise price ofoutstanding options,warrants and rights |   |      |  |  | Number ofsecurities 
remainingavailable for futureissuance underequity compensationplans (excludingsecurities reflectedin column (a)) | 
|                                                       |  |  |  | (a)                                                                                   |            |  |  |  | (b)                                                                      |   |      |  |  | (c)                                                                                                                                   | 
|Equity compensation plans approved by stockholders     |  |  |  |                                                                                       | 9,764,076  |  |  |  |                                                                          | $ | 0.91 |  |  |                                                                                                                                       |  |  | 1,541,772 | 
|Equity compensation plans not approved by stockholders |  |  |  |                                                                                       | 1,400,000  |  |  |  |                                                                          | $ | 1.10 |  |  |                                                                                                                                       |  |  |          | 
|                                                       |  |  |  |                                                                                       |            |  |  |  |                                                                          |   |      |  |  |                                                                                                                                       |  |  |           | 
|Total                                                  |  |  |  |                                                                                       | 11,164,076 |  |  |  |                                                                          | $ | 0.94 |  |  |                                                                                                                                       |  |  | 1,541,772 | 



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Our stockholders approved our Equity Plan. The only awards that are outstanding under that
plan as of March 1, 2010 are options to acquire 2,978,671 shares of our common stock and restricted stock totaling 69,231 shares. In September 2008 the shareholders increased the authorized number of shares of our common stock available to be
issued under our Equity Plan from 1,500,000 shares to 3,400,000 shares. In March 2010, our Board approved an increase in the number of shares of our common stock available to be issued under our Equity Plan from 3,400,000 shares to 6,000,000 shares,
which was approved by our shareholders in September 2010.

In January 2007, we granted to Dr. Keith L. Black a
fully-vested, ten-year option to purchase 1,500,000 shares of our common stock at an exercise price of $1.10 per share in consideration for his agreeing to serve as the Chairman of our Scientific Advisory Board. Dr. Black has exercised 100,000
shares of this option.

In November 2006, we granted to Dr. John Yu (1) an option to purchase 150,000 shares of our
common stock in consideration for his relinquishment of his royalty interest in the cellular-based therapy technology that we licensed and (2) an option to purchase 5,783,424 shares of our common stock in consideration of his agreeing to serve
as our Chief Scientific Officer for a one-year term. Both options have an exercise price of $1.00 per share, a term of ten years and were fully vested upon grant. In November 2006, our stockholders approved these option grants to Dr. Yu.

In November 2006, we granted to Technomedics Management & Systems, Inc. an option to purchase 300,000 shares of our
common stock for a term of seven years at an exercise price of $1.00 per share in consideration for Dr. Mosk agreeing to serve as our Non-Executive Chairman of the Board on a part-time basis for one year. Upon grant, 150,000 shares of the
option vested, with the balance of the shares to vest in four equal quarterly installments following the date of grant. Dr. Mosk voluntarily resigned as our Non-Executive Chairman of the Board in January 2007 and resigned as a director on
March 19, 2008. The balance of Technomedics 150,000 unvested option shares were cancelled as a result of Dr. Mosks voluntary resignation: The Technomedics option covering the remaining 150,000 vested option shares expired
unexercised on March 18, 2010.



|Item 13. | Certain Relationships and Related Transactions, and Director Independence.
|-------- | --------------------------------------------------------------------------

Transactions with Related Persons

None

Independent Directors

Information regarding our independent directors is set forth above in Item 10 under the captions Business Experience and
Directorships and Committees of the Board.



|Item 14. | Principal Accounting Fees and Services.
|-------- | ---------------------------------------

On October 1, 2010, the Companys independent registered public accounting firm, Stonefield Josephson, Inc. (Stonefield), combined its practice with Marcum LLP. Accordingly,
effective October 1, 2010, Stonefield effectively resigned as the Companys independent registered public accounting firm and MarcumStonefield, a division of Marcum LLP, became the Companys independent registered public accounting
firm. The Audit Committee has appointed MarcumStonefield as our independent registered public accounting firm for the fiscal year ending December 31, 2010. The following table shows the fees that were paid or accrued by us for audit and other
services provided by Stonefield for the fiscal 2009 and by MarcumStonefield for fiscal year 2010.



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|                       |  |      |        |  |      |   |        | 
|---------------------- |  | ---- | ------ |  | ---- | - | ------ | 
|                       |  | 2009 |        |  | 2010 |  
|Audit Fees (1)         |  | $    | 49,249 |  |      | $ | 54,770 | 
|Audit-Related Fees (2) |  |      |       |  |      |   |       | 
|Tax Fees (3)           |  | $    | 2,915  |  |      | $ | 3,000  | 
|All Other Fees         |  | $    | 13,495 |  |      | $ | 39,650 | 
|                       |  |      |        |  |      |   |        | 
|Total                  |  | $    | 65,659 |  |      | $ | 97,420 | 
|                       |  |      |        |  |      |   |        | 



|(1) | Audit fees represent fees for professional services provided in connection with the audit of our annual financial statements and the review of our financial statements
included in our Form 10-Q quarterly reports and services that are normally provided in connection with statutory or regulatory filings for the 2009 and 2010 fiscal years.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Audit-related fees represent fees for assurance and related services that are reasonably related to the performance of the audit or review of our financial statements
and not reported above under Audit Fees.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Tax fees represent fees for professional services related to tax compliance, tax advice and tax planning.
|--- | ---------------------------------------------------------------------------------------------------------

All audit related services, tax services and other services rendered by Stonefield were pre-approved by our Board of Directors or Audit
Committee. The Audit Committee has adopted a pre-approval policy that provides for the pre-approval of all of the services that were performed for us by Stonefield and that are now performed for us by MarcumStonefield. The policy authorizes the
Audit Committee to delegate to one or more of its members pre-approval authority with respect to permitted services. Pursuant to this policy, the Board delegated such authority to the Chairman of the Audit Committee. All pre-approval decisions must
be reported to the Audit Committee at its next meeting. The Audit Committee has concluded that the provision of the non-audit services listed above was compatible with maintaining the independence of Stonefield and subsequently with maintaining the
independence of MarcumStonefield.

PART IV



|Item 15. | Exhibits and Financial Statement Schedules.
|-------- | -------------------------------------------

The Companys financial statements and related notes thereto are listed and included in this Annual Report beginning on page F-1. The following exhibits are filed with, or are incorporated by
reference into, this Annual Report.



|              |  |                                                                                                                                                                                                                                                        
|------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                                                                            
|2.1           |  | Agreement and Plan of Reorganization dated as of May 5, 2005, as amended, among Patco Industries Subsidiary, Inc., William C. Patridge, and Spectral Molecular Imaging, Inc., as
amended on June 30, 2005, September 26, 2005 and January 20, 2006. (1)
|              | 
|3.1           |  | Amended and Restated Certificate of Incorporation of ImmunoCellular Therapeutics, Ltd. (2)                                                                                                                                                             
|              | 
|3.2           |  | Certificate of Amendment to Amended and Restated Certificate of Incorporation of ImmunoCellular Therapeutics, Ltd. (2)                                                                                                                                 
|              | 
|3.3           |  | Certificate of Amendment to Amended and Restated Certificate of Incorporation of ImmunoCellular Therapeutics, Ltd. (3)                                                                                                                                 
|              | 
|3.4           |  | Amended and Restated Bylaws of ImmunoCellular Therapeutics, Ltd. (4)                                                                                                                                                                                   
|              | 
|3.5           |  | Amended and Restated Bylaws of ImmunoCellular Therapeutics, Ltd. (25)                                                                                                                                                                                  
|              | 
|3.6           |  | Amended and Restated 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (25)                                                                                                                                                              
|              | 
|4.1           |  | Form of Common Stock Certificate for ImmunoCellular Therapeutics, Ltd. (5)                                                                                                                                                                             
|              | 
|4.2           |  | Form of Subscription Agreement containing registration rights issued by Spectral Molecular Imaging, Inc. in January 2006 and assumed by ImmunoCellular Therapeutics, Ltd.
(4)                                                                          



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|     |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|---- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|4.3  |  | Form of Warrant issued in January 2006 to purchase shares of the common stock of Spectral Molecular Imaging, Inc. and assumed by ImmunoCellular Therapeutics, Ltd.
(4)                                                                                                                                                                                                                                                                                                       
|     | 
|4.4  |  | Subscription Agreement dated as of February 16, 2007 between ImmunoCellular Therapeutics, Ltd. and RAB Special Situations (Master) Fund Limited. (6)                                                                                                                                                                                                                                                                                                                         
|     | 
|4.5  |  | Letter Agreement dated as of February 16, 2007 between ImmunoCellular Therapeutics, Ltd. and RAB Special Situations (Master) Fund Limited. (6)                                                                                                                                                                                                                                                                                                                               
|     | 
|4.6  |  | Subscription Agreement dated as of April 19, 2007 between ImmunoCellular Therapeutics, Ltd. and RAB Special Situations (Master) Fund Limited. (6)                                                                                                                                                                                                                                                                                                                            
|     | 
|4.7  |  | Warrant dated as of February 16, 2007 issued by ImmunoCellular Therapeutics, Ltd. to Credit Suisse Client Nominees (UK) Limited, as nominee for RAB Special Situations (Master) Fund
Limited, for the purchase of 800,000 shares of the common stock of ImmunoCellular Therapeutics, Ltd. (6)                                                                                                                                                                                
|     | 
|4.8  |  | Warrant dated as of February 16, 2007 issued by ImmunoCellular Therapeutics, Ltd. to Credit Suisse Client Nominees (UK) Limited, as nominee for RAB Special Situations (Master) Fund
Limited, for the purchase of 533,334 shares of the common stock of ImmunoCellular Therapeutics, Ltd. (6)                                                                                                                                                                                
|     | 
|4.9  |  | Warrant dated as of April 19, 2007 issued by ImmunoCellular Therapeutics, Ltd. to Credit Suisse Client Nominees (UK) Limited, as nominee for RAB Special Situations (Master)
Fund Limited, for the purchase of 200,000 shares of the common stock of ImmunoCellular Therapeutics, Ltd. (6)                                                                                                                                                                                   
|     | 
|4.10 |  | Warrant dated as of April 19, 2007 issued by ImmunoCellular Therapeutics, Ltd. to Credit Suisse Client Nominees (UK) Limited, as nominee for RAB Special Situations (Master)
Fund Limited, for the purchase of 133,334 shares of the common stock of ImmunoCellular Therapeutics, Ltd. (6)                                                                                                                                                                                   
|     | 
|4.11 |  | Form of Subscription Agreement containing registration rights between the participants in the April/May 2007 private placement and ImmunoCellular Therapeutics, Ltd.
(7)                                                                                                                                                                                                                                                                                                     
|     | 
|4.12 |  | Form of Warrant issued to participants in the April/May 2007 private placement to purchase shares of common stock of ImmunoCellular Therapeutics, Ltd. (7)                                                                                                                                                                                                                                                                                                                   
|     | 
|4.13 |  | Form of Notice of Exercise of Warrants delivered by ImmunoCellular Therapeutics, Ltd. in January 2009 in connection with the reduction from $2.50 to $0.25 per share of the exercise
price of warrants to purchase a total of 6,112,583 shares of common stock of ImmunoCellular Therapeutics, Ltd. and in connection with the extension of the expiration date of warrants to purchase a total of 6,412,583 shares of common stock of
ImmunoCellular Therapeutics, Ltd. (17)
|     | 
|4.14 |  | Certificate of Designations of Preferences, Rights and Limitations of Series A Preferred Stock dated December 3, 2009. (20)                                                                                                                                                                                                                                                                                                                                                  
|     | 
|4.15 |  | Warrant dated December 3, 2009 issued by ImmunoCellular Therapeutics, Ltd. to Socius Capital Group, LLC d/b/a Socius Life Sciences Capital Group, LLC (20)                                                                                                                                                                                                                                                                                                                   
|     | 
|4.16 |  | Amended Certificate of Designations of Preferences, Rights and Limitations of Series A Preferred Stock dated May 3, 2010. (22)                                                                                                                                                                                                                                                                                                                                               
|     | 
|4.17 |  | Form of Warrant issued to participants in the March 2010 private placement to purchase shares of common stock of ImmunoCellular Therapeutics, Ltd. (22)                                                                                                                                                                                                                                                                                                                      
|     | 
|4.18 |  | Warrant dated May 2, 2010 for 1,350,000 shares issued by ImmunoCellular Therapeutics, Ltd. to Socius CG II, Ltd. (22)                                                                                                                                                                                                                                                                                                                                                        



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|      |  |                                                                                                                                                              
|----- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------
|4.19  |  | Form of Warrant issued to participants in the February 2011 private placement to purchase shares of common stock of ImmunoCellular Therapeutics, Ltd. (26)   
|      | 
|10.1  |  | Exclusive License Agreement dated as of November 17, 2006 between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd. (8)                     
|      | 
|10.2  |  | First Amendment to Exclusive License Agreement dated as of June 16, 2008 2006, between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd. (9)
|      | 
|10.3  |  | Stock Purchase Agreement dated as of November 17, 2006 between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd. (8)                         
|      | 
|10.4  |  | Registration Rights Agreement dated as of November 17, 2006 between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd. (8)                    
|      | 
|10.5  |  | Securities Purchase Agreement dated as of November 17, 2006 between Dr. John Yu and ImmunoCellular Therapeutics, Ltd. (8)                                    
|      | 
|10.6  |  | Agreement dated as of November 17, 2006 between Dr. John Yu and ImmunoCellular Therapeutics, Ltd.* (8)                                                       
|      | 
|10.7  |  | Nonqualified Stock Option Agreement dated as of November 17, 2006 between Dr. John Yu and ImmunoCellular Therapeutics, Ltd.* (8)                             
|      | 
|10.8  |  | Registration Rights Agreement dated as of November 17, 2006 between Dr. John Yu and ImmunoCellular Therapeutics, Ltd. (8)                                    
|      | 
|10.9  |  | 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (4)                                                                                          
|      | 
|10.10 |  | Amendment No. 1 to the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (10)                                                                  
|      | 
|10.11 |  | Amendment No. 2 to the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (11)                                                                  
|      | 
|10.12 |  | Amendment No. 3 to the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (11)                                                                  
|      | 
|10.13 |  | Amendment No. 4 to the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (9)                                                                   
|      | 
|10.14 |  | Form of Non-Qualified Stock Option Agreement for the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (12)                                    
|      | 
|10.15 |  | Form of Incentive Stock Option Agreement for the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (12)                                        
|      | 
|10.16 |  | Employment Agreement dated as of February 18, 2008 between Dr. Manish Singh and ImmunoCellular Therapeutics, Ltd.* (11)                                      
|      | 
|10.17 |  | Employment Agreement dated as of February 18, 2009 between Dr. Manish Singh and ImmunoCellular Therapeutics, Ltd.* (17)                                      
|      | 
|10.18 |  | Employment Agreement dated as of November 5, 2007 between C. Kirk Peacock and ImmunoCellular Therapeutics, Ltd. (13)                                         
|      | 
|10.19 |  | Employment Agreement dated as of October 30, 2008 between C. Kirk Peacock and ImmunoCellular Therapeutics, Ltd.* (17)                                        
|      | 
|10.20 |  | Agreement dated as of July 7, 2006 between Technomedics Management & Systems, Inc. and ImmunoCellular Therapeutics, Ltd. (14)                                
|      | 
|10.21 |  | Agreement dated as of November 17, 2006 between Technomedics Management & Systems, Inc. and ImmunoCellular Therapeutics, Ltd.* (5)                           



57



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|      |  |                                                                                                                                                                                            
|----- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|10.22 |  | Memorandum of Agreement dated as of November 21, 2007 between Molecular Discoveries LLC and ImmunoCellular Therapeutics, Ltd. (11)                                                         
|      | 
|10.23 |  | Agreement dated as of February 14, 2008 between Molecular Discoveries, LLC and ImmunoCellular Therapeutics, Ltd. (11)                                                                      
|      | 
|10.24 |  | Registration Rights Agreement dated as of April 14, 2008, between Molecular Discoveries, LLC and ImmunoCellular Therapeutics, Ltd. (15)                                                    
|      | 
|10.25 |  | Agreement dated as of February 14, 2008 between Dr. Cohava Gelber and ImmunoCellular Therapeutics, Ltd. (11)*                                                                              
|      | 
|10.26 |  | Agreement dated as of August 1, 2008 between Dr. Cohava Gelber and ImmunoCellular Therapeutics, Ltd.. * (17)                                                                               
|      | 
|10.27 |  | Agreement dated as of September 1, 2008 between James G. Bender and ImmunoCellular Therapeutics, Ltd. (16) *                                                                               
|      | 
|10.28 |  | Office lease dated April 28, 2008 between Regent Business Centers and ImmunoCellular Therapeutics, Ltd., as amended. (17)                                                                  
|      | 
|10.29 |  | Amendment No. 1 to Agreement dated as of May 1, 2009 to Agreement dated October 30, 2008 between C. Kirk Peacock and ImmunoCellular Therapeutics, Ltd.
*(18)                               
|      | 
|10.30 |  | Second Amendment dated August 1, 2009 to Exclusive License Agreement dated as of November 1, 2006 between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd.
(19)           
|      | 
|10.31 |  | Preferred Stock Purchase Agreement dated as of December 3, 2009 between ImmunoCellular Therapeutics, Ltd. and Socius Capital Group, LLC d/b/a Socius Life Sciences Capital
Group, LLC. (20)
|      | 
|10.32 |  | Employment Agreement dated as of October 30, 2009 between C. Kirk Peacock and ImmunoCellular Therapeutics, Ltd. * (21)                                                                     
|      | 
|10.33 |  | Employment Agreement dated as of February 1, 2010 between James G. Bender and ImmunoCellular Therapeutics, Ltd. * (27)                                                                     
|      | 
|10.34 |  | Employment Agreement dated as of February 18, 2010 between Dr. Manish Singh and ImmunoCellular Therapeutics, Ltd. * (27)                                                                   
|      | 
|10.35 |  | Agreement dated March 1, 2010 between Dr. John Yu and ImmunoCellular Therapeutics, Ltd. * (27)                                                                                             
|      | 
|10.36 |  | Securities Purchase Agreement dated March 29, 2010 between participants in the March 2010 private placement and ImmunoCellular Therapeutics, Ltd. (23)                                     
|      | 
|10.37 |  | Form of Registration Rights Agreement dated as of March 29, 2010 between participants in the March 2010 private placement and ImmunoCellular Therapeutics, Ltd. (22)                       
|      | 
|10.38 |  | Agreement dated as of March 4, 2010 between Dr. Elma Hawkins and ImmunoCellular Therapeutics, Ltd.* (22)                                                                                   
|      | 
|10.39 |  | Office Lease dated April 1, 2010 between Regent Business Centers and ImmunoCellular Therapeutics, Ltd. (22)                                                                                
|      | 
|10.40 |  | Modification Agreement dated May 2, 2010 among Socius CG II, Ltd., Socius Life Sciences Capital Group, LLC and ImmunoCellular Therapeutics, Ltd. (22)                                      
|      | 
|10.41 |  | Third Amendment dated March 26, 2010 to Exclusive License Agreement dated as of November 1, 2006 between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd.
(22)            



58



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|      |  |                                                                                                                                                                            
|----- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|10.42 |  | Securities Purchase Agreement dated May 12, 2010 between participants in the May 2010 private placement and ImmunoCellular Therapeutics, Ltd. (23)                         
|      | 
|10.43 |  | Form of Registration Rights Agreement between participants in the May 2010 private placement and ImmunoCellular Therapeutics, Ltd. (23)                                    
|      | 
|10.44 |  | Employment Agreement dated as of October 30, 2010 between C. Kirk Peacock and ImmunoCellular Therapeutics, Ltd.* (24)                                                      
|      | 
|10.45 |  | Office Lease dated May 7, 2010 between Regent Business Centers and ImmunoCellular Therapeutics, Ltd. (23)                                                                  
|      | 
|10.46 |  | Purchase Agreement, dated as of February 22, 2011, by and between each investor named therein and ImmunoCellular Therapeutics, Ltd. (26)                                   
|      | 
|10.47 |  | Registration Rights Agreement, dated as of February 22, 2011, by and among the investors named therein and ImmunoCellular Therapeutics, Ltd. (26)                          
|      | 
|10.48 |  | Exclusive Sublicense Agreement dated May 28, 2010 between Targepeutics, Inc. and ImmunoCellular Therapeutics, Ltd.  **                                                    
|      | 
|10.49 |  | Sponsored Research and Vaccine Production Agreement dated January 1, 2011 between The Trustees of the University of Pennsylvania and ImmunoCellular Therapeutics, Ltd. 
**
|      | 
|10.50 |  | Placement agent agreement dated March 30, 2010 between Gilford Securities Incorporated and ImmunoCellular Therapeutics, Ltd. **                                            
|      | 
|10.51 |  | Placement agent agreement dated April 7, 2010 between Scarsdale Equities LLC and ImmunoCellular Therapeutics, Ltd. **                                                      
|      | 
|10.52 |  | Consulting Agreement dated October 1, 2010 between JFS Investments and ImmunoCellular Therapeutics, Ltd.. **                                                               
|      | 
|10.53 |  | Advisory services agreement dated October 1, 2010 between Garden State Securities Inc. and ImmunoCellular Therapeutics, Ltd. **                                            
|      | 
|10.54 |  | Co-placement Agents Agreement dated January 31, 2011 among Summer Street Research Partners, Dawson James Securities, Inc. and ImmunoCellular Therapeutics, Ltd. **         
|      | 
|23.1  |  | Consent of Marcum LLP. **                                                                                                                                                  
|      | 
|23.2  |  | Consent of Stonefield Josephson, Inc. **                                                                                                                                   
|      | 
|31.1  |  | Certification of the registrants Principal Executive Officer under Exchange Act Rule 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of
2002.**   
|      | 
|31.2  |  | Certification of the registrants Principal Financial Officer under Exchange Act Rule 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of
2002.**   
|      | 
|32.1  |  | Certification of the registrants Principal Executive Officer under 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
2002.**        
|      | 
|32.2  |  | Certification of the registrants Principal Financial Officer under 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
2002.**        



| | Certain portions of the exhibit have been omitted based upon a request for confidential treatment filed by us with the Securities and Exchange Commission. The omitted
portions of the exhibit have been separately filed by us with the Securities and Exchange Commission.
|- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|* | Indicates a management contract or compensatory plan or arrangement.
|- | --------------------------------------------------------------------

|** | Filed with this Annual Report on Form 10-K.
|-- | -------------------------------------------

|(1) | Previously filed by us on January 26, 2006 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|--- | --------------------------------------------------------------------------------------------------------------------------------



59



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|(2) | Previously filed by us on November 3, 2006 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|--- | --------------------------------------------------------------------------------------------------------------------------------

|(3) | Previously filed by us on May 9, 2007 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|--- | ---------------------------------------------------------------------------------------------------------------------------

|(4) | Previously filed by us on February 6, 2006 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|--- | --------------------------------------------------------------------------------------------------------------------------------

|(5) | Previously filed by us on February 12, 2007 as an exhibit to our Registration Statement on Form SB-2, File No. 333-140598, and incorporated herein by
reference.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Previously filed by us on May 1, 2007 as an exhibit to our Registration Statement on Form SB-2, File No. 333-142480, and incorporated herein by reference.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------

|(7) | Previously filed by us on July 12, 2007 as an exhibit to our Registration Statement on Form SB-2, File No. 333-144521, and incorporated herein by reference
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------

|(8) | Previously filed by us on November 22, 2006 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|--- | ---------------------------------------------------------------------------------------------------------------------------------

|(9) | Previously filed by us on August 14, 2008 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|--- | ----------------------------------------------------------------------------------------------------------------------------------

|(10) | Previously filed by us on September 14, 2007 as an exhibit to our Registration Statement on Form SB-2/A and incorporated herein by reference.
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------

|(11) | Previously filed by us on March 25, 2008 as an exhibit to our Annual Report on Form 10-KSB and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------------------

|(12) | Previously filed by us on November 9, 2007 as an exhibit to our Registration Statement on Form S-8, File No. 333-147278, and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------------------------------------------------

|(13) | Previously filed by us on November 6, 2007 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------------------

|(14) | Previously filed by us on April 2, 2007 as an exhibit to our Annual Report on Form 10-KSB and incorporated herein by reference.
|---- | -------------------------------------------------------------------------------------------------------------------------------

|(15) | Previously filed by us on April 16, 2008 as an exhibit to our Registration Statement on Form S-1, File No. 333-150277, and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------

|(16) | Previously filed by us on November 13, 2008 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------------

|(17) | Previously filed by us on March 30, 2009 as an exhibit to our Annual Report on Form 10-K and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------

|(18) | Previously filed by us on August 14, 2009 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|---- | ----------------------------------------------------------------------------------------------------------------------------------

|(19) | Previously filed by us on November 13, 2009 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------------

|(20) | Previously filed by us on December 7, 2009 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------------------

|(21) | Previously filed by us on December 23, 2009 as an exhibit to our Registration Statement on Form S-1 and incorporated herein by reference.
|---- | -----------------------------------------------------------------------------------------------------------------------------------------

|(22) | Previously filed by us on May 12, 2010 as an exhibit to our Registration Statement on Form S-1 to SB-2, File No. 333-144521 and incorporated herein by
reference.
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------

|(23) | Previously filed by us on May 18, 2010 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|---- | -------------------------------------------------------------------------------------------------------------------------------

|(24) | Previously filed by us on November 15, 2010 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------------

|(25) | Previously filed by us on January 11, 2011 as an exhibit to our Registration Statement on Form S-8 and incorporated herein by reference.
|---- | ----------------------------------------------------------------------------------------------------------------------------------------

|(26) | Previously filed by us on February 25, 2011 as an exhibit to our current report on Form 8-K and incorporated herein by reference.
|---- | ---------------------------------------------------------------------------------------------------------------------------------

|(27) | Previously filed by us on March 31, 2010 as an exhibit to our Annual Report on Form 10-K and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------



60



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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly
authorized.



|                     |  |  |  |                                   |  |                                       |  | 
|-------------------- |  |  |  | --------------------------------- |  | ------------------------------------- |  | 
|                     |  |  |  | IMMUNOCELLULAR THERAPEUTICS, LTD.
|                     |  |  | 
|Date: March 31, 2011 |  |  |  | By:                               |  | /s/ Manish Singh                     
|                     |  |  |  |                                   |  | Manish Singh, Ph.D.                  
|                     |  |  |  |                                   |  | President and Chief Executive Officer

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates
indicated.



|                                                |  |                                                                               |  |               
|----------------------------------------------- |  | ----------------------------------------------------------------------------- |  | --------------
|Signature                                       |  | Title                                                                         |  | Date          
|                                                |  |                                                                              
|/s/ Manish Singh
Manish Singh, Ph.D.            |  | President, Chief Executive Officer and Director (Principal Executive Officer) |  | March 31, 2011
|                                                |  |                                                                              
|/s/ C. Kirk Peacock
C. Kirk Peacock             |  | Chief Financial Officer (Principal Financial and Accounting Officer)          |  | March 31, 2011
|                                                |  |                                                                              
|/s/ Jacqueline Brandwynne
Jacqueline Brandwynne |  | Director                                                                      |  | March 31, 2011
|                                                |  |                                                                              
|/s/ Richard A. Cowell
Richard A. Cowell         |  | Director                                                                      |  | March 31, 2011
|                                                |  |                                                                              
|/s/ Navdeep Jaikaria
Navdeep Jaikaria, Ph.D.    |  | Director                                                                      |  | March 31, 2011
|                                                |  |                                                                              
|/s/ Rahul Singhvi
Rahul Singhvi, Sc.D.          |  | Director                                                                      |  | March 31, 2011
|                                                |  |                                                                              
|/s/ John Yu John Yu, M.D.                       |  | Director                                                                      |  | March 31, 2011



61



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ImmunoCellular Therapeutics, Ltd.

(a Development Stage Company)

Index to Financial Statements



|                                                                                                                                                               |  |      |     | 
|-------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ---- | --- | 
|                                                                                                                                                               |  | Page |    
|Financial Statements:                                                                                                                                          |  |      |     | 
|                                                                                                                                                               | 
|Report of Independent Registered Public Accounting Firm  Marcum LLP                                                                                           |  |      | F-2 | 
|Report of Independent Registered Public Accounting Firm  Stonefield Josephson,
Inc.                                                                           |  |      | F-3 | 
|Balance Sheets as of December 31, 2009 and 2010                                                                                                                |  |      | F-4 | 
|Statements of Operations for each of the three fiscal years in the period ended December 
31, 2010 and from February 25, 2004 (Inception) to December 31, 2010 |  |      | F-5 | 
|Statements of Shareholders Equity (Deficit) from February 25, 2004 (Inception) to December 
31, 2010                                                           |  |      | F-6 | 
|Statements of Cash Flows for each of the three years in the period ended December 
31, 2010 and from February 25, 2004 (Inception) to December 31, 2010        |  |      | F-7 | 
|Notes to Consolidated Financial Statements                                                                                                                     |  |      | F-8 | 



F-1



---

##### Table of Contents

Report of Independent Registered Public Accounting Firm

To the Audit Committee of the

Board of
Directors and Shareholders of ImmunoCellular Therapeutics, Ltd.

We have audited the accompanying balance sheet of ImmunoCellular
Therapeutics, Ltd. (a development stage company) (the Company) as of December 31, 2010, and the related statements of operations, changes in shareholders equity (deficit) and cash flows for the year then ended, and for the
period from February 25, 2004 (inception) to December 31, 2010. These financial statements are the responsibility of the Companys management. Our responsibility is to express an opinion on these financial statements based on our
audit. The accompanying financial statements of the Company for the period from February 25, 2004 (inception) to December 31, 2009 were not audited by us. Those statements were audited by other auditors whose report, dated March 29, 2010
expressed an unqualified opinion on those statements and included an explanatory paragraph regarding the Company s ability to continue as a going concern. The financial statements for the period from February 25, 2004 (inception) to December
31, 2009 reflect a net loss of $14,711,146. Our opinion, insofar as it relates to the amounts included for such prior periods as indicated in the accompanying financial statements for such periods from February 25, 2004 (inception) through December
31, 2009, is based solely on the report of such other auditors.

We conducted our audit in accordance with the standards of the Public Company
Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. The Company is not required to have, nor
were we engaged to perform, an audit of its internal control over financial reporting. Our audit included consideration of internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances,
but not for the purpose of expressing an opinion on the effectiveness of the Companys internal control over financial reporting. Accordingly, we express no such opinion. An audit also includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audit provides a
reasonable basis for our opinion.

In our opinion, based on our audit and the report of the other auditors, the financial statements referred
to above present fairly, in all material respects, the financial position of ImmunoCellular Therapeutics, Ltd. (a development stage company) as of December 31, 2010 and the results of its operations and its cash flows for the year then ended
and for the period from February 25, 2004 (inception) to December 31, 2010 in conformity with accounting principles generally accepted in the United States of America.

Marcum LLP

Los Angeles, California

March 31, 2011



F-2



---

##### Table of Contents

Report of Independent Registered Public Accounting Firm

To the Audit Committee of the

Board of
Directors and Stockholders of ImmunoCellular Therapeutics, Ltd.

We have audited the accompanying balance sheet of ImmunoCellular
Therapeutics, Ltd. (a development stage company) (the Company) as of December 31, 2009, and the related statements of operations, shareholders equity (deficit) and cash flows for the years ended December 31, 2009 and
2008, and for the period from February 25, 2004 (inception) to December 31, 2009. These financial statements are the responsibility of the Companys management. Our responsibility is to express an opinion on these financial statements
based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United
States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. The company is not required to have, nor were we engaged to perform, an
audit of its internal control over financial reporting. Our audit included consideration of internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose of
expressing an opinion on the effectiveness of the companys internal control over financial reporting. Accordingly, we express no such opinion. An audit also includes examining, on a test basis, evidence supporting the amounts and disclosures
in the financial statements, assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our
opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of
ImmunoCellular Therapeutics, Ltd. (a development stage company) as of December 31, 2009, and the results of its operations and its cash flows for the years ended December 31, 2009, and for the period from February 25, 2004 (inception)
to December 31, 2009 in conformity with accounting principles generally accepted in the United States of America.

Stonefield Josephson,
Inc.

Los Angeles, California

March 31, 2010



F-3



---

##### Table of Contents

ImmunoCellular Therapeutics, Ltd.

(A Development Stage Company)

Balance Sheets



|                                                                                                                                                                                          |  |                  |             |   |                  |   |             |  
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ---------------- | ----------- | - | ---------------- | - | ----------- | -
|                                                                                                                                                                                          |  | December 31,2009 |             |   | December 31,2010 |  
|Assets                                                                                                                                                                                    |  |                  |             |   |                  |   |             |  
|Current assets:                                                                                                                                                                           |  |                  |             |   |                  |   |             |  
|Cash and cash equivalents                                                                                                                                                                 |  | $                | 331,353     |   |                  | $ | 5,319,776   |  
|Short-term investments                                                                                                                                                                    |  |                  | 1,075,903   |   |                  |   |            |  
|Other assets                                                                                                                                                                              |  |                  | 21,903      |   |                  |   | 24,033      |  
|                                                                                                                                                                                          |  |                  |             |   |                  |   |             |  
|Total current assets                                                                                                                                                                      |  |                  | 1,429,159   |   |                  |   | 5,343,809   |  
|Fixed assets, net                                                                                                                                                                         |  |                  | 5,428       |   |                  |   | 12,367      |  
|Deferred financing costs                                                                                                                                                                  |  |                  | 30,282      |   |                  |   |            |  
|Other assets                                                                                                                                                                              |  |                  | 7,847       |   |                  |   | 8,974       |  
|                                                                                                                                                                                          |  |                  |             |   |                  |   |             |  
|Total assets                                                                                                                                                                              |  | $                | 1,472,716   |   |                  | $ | 5,365,150   |  
|                                                                                                                                                                                          |  |                  |             |   |                  |   |             |  
|Liability and Shareholders Equity (Deficit)                                                                                                                                              |  |                  |             |   |                  |   |             |  
|Current liabilities:                                                                                                                                                                      |  |                  |             |   |                  |   |             |  
|Accounts payable                                                                                                                                                                          |  | $                | 225,601     |   |                  | $ | 171,065     |  
|Accrued liabilities                                                                                                                                                                       |  |                  | 150,120     |   |                  |   | 276,384     |  
|                                                                                                                                                                                          |  |                  |             |   |                  |   |             |  
|Total current liabilities                                                                                                                                                                 |  |                  | 375,721     |   |                  |   | 447,449     |  
|                                                                                                                                                                                          |  |                  |             |   |                  |   |             |  
|Warrant liabilities                                                                                                                                                                       |  |                  |            |   |                  |   | 2,581,871   |  
|                                                                                                                                                                                          |  |                  |             |   |                  |   |             |  
|Commitments and contingencies (note 5)                                                                                                                                                    |  |                  |            |   |                  |   |            |  
|                                                                                                                                                                                          |  |                  |             |   |                  |   |             |  
|Shareholders equity:                                                                                                                                                                     |  |                  |             |   |                  |   |             |  
|Preferred stock $0.0001 par value, 1,000,000 shares authorized; 0 shares outstanding as of December 31, 2009 and
December 31, 2010                                                        |  |                  |            |   |                  |   |            |  
|Common stock, $0.0001 par value; 74,000,000 shares authorized; 14,867,842 shares and 22,213,602 shares issued and outstanding as
of December 31, 2009 and December 31, 2010, respectively |  |                  | 1,487       |   |                  |   | 2,221       |  
|Additional paid in capital                                                                                                                                                                |  |                  | 15,859,322  |   |                  |   | 25,341,679  |  
|Promissory note                                                                                                                                                                           |  |                  | (52,668     | ) |                  |   | (54,282     | )
|Deficit accumulated during the development stage                                                                                                                                          |  |                  | (14,711,146 | ) |                  |   | (22,953,788 | )
|                                                                                                                                                                                          |  |                  |             |   |                  |   |             |  
|Total shareholders equity                                                                                                                                                                |  |                  | 1,096,995   |   |                  |   | 2,335,830   |  
|                                                                                                                                                                                          |  |                  |             |   |                  |   |             |  
|Total liabilities and shareholders equity                                                                                                                                                |  | $                | 1,472,716   |   |                  | $ | 5,365,150   |  
|                                                                                                                                                                                          |  |                  |             |   |                  |   |             |  

The accompanying notes are an integral part of these financial statements.



F-4



---

##### Table of Contents

ImmunoCellular Therapeutics, Ltd.

(A Development Stage Company)

Statements of Operations



|                                                 |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|------------------------------------------------ |  | --------------------------------- | ---------- | - | --------------------------------- | - | ---------- | --------------------------------- |  | - | ---------------------------------------------- | - |  | - | ----------- | -
|                                                 |  | For the YearEndedDecember 31,2008 |            |   | For the YearEndedDecember 31,2009 |   |            | For the YearEndedDecember 31,2010 |  |   | February 25,2004(Inception) toDecember 31,2010 |  
|Revenues                                         |  | $                                 |           |   |                                   | $ | 300,000    |                                   |  | $ |                                               |   |  | $ | 300,000     |  
|Expenses:                                        |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Research and development                         |  |                                   | 1,296,772  |   |                                   |   | 962,526    |                                   |  |   | 2,292,630                                      |   |  |   | 5,560,267   |  
|Merger costs                                     |  |                                   |           |   |                                   |   |           |                                   |  |   |                                               |   |  |   | 73,977      |  
|Stock-based compensation                         |  |                                   | 513,357    |   |                                   |   | 308,303    |                                   |  |   | 807,853                                        |   |  |   | 7,029,872   |  
|General and administrative                       |  |                                   | 1,366,146  |   |                                   |   | 1,677,421  |                                   |  |   | 2,035,526                                      |   |  |   | 6,544,723   |  
|                                                 |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Total expenses                                   |  |                                   | 3,176,275  |   |                                   |   | 2,948,250  |                                   |  |   | 5,136,009                                      |   |  |   | 19,208,839  |  
|                                                 |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Loss before other income and income taxes        |  |                                   | (3,176,275 | ) |                                   |   | (2,648,250 | )                                 |  |   | (5,136,009                                     | ) |  |   | (18,908,839 | )
|                                                 |  |                                   |            |  
|Other income:                                    |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Interest income                                  |  |                                   | 116,545    |   |                                   |   | 22,045     |                                   |  |   | 4,105                                          |   |  |   | 334,789     |  
|Change in fair value of warrant liability        |  |                                   |           |   |                                   |   |           |                                   |  |   | (1,018,238                                     | ) |  |   | (2,287,238  | )
|                                                 |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|                                                 |  |                                   | (3,059,730 | ) |                                   |   | (2,626,205 | )                                 |  |   | (6,150,142                                     | ) |  |   | (20,861,288 | )
|                                                 |  |                                   |            |  
|Income taxes                                     |  |                                   |           |   |                                   |   |           |                                   |  |   |                                               |   |  |   |            |  
|                                                 |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Net loss                                         |  |                                   | (3,059,730 | ) |                                   |   | (2,626,205 | )                                 |  |   | (6,150,142                                     | ) |  |   | (20,861,288 | )
|Deemed dividend on redemption of preferred stock |  |                                   |           |   |                                   |   |           |                                   |  |   | 2,092,500                                      |   |  |   | 2,092,500   |  
|                                                 |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Net loss attributable to common stock            |  | $                                 | (3,059,730 | ) |                                   | $ | (2,626,205 | )                                 |  | $ | (8,242,642                                     | ) |  | $ | (22,953,788 | )
|                                                 |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Weighted average number of common shares:        |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Basic and diluted                                |  |                                   | 12,540,301 |   |                                   |   | 13,719,991 |                                   |  |   | 19,188,541                                     |   |  |   | 11,295,755  |  
|                                                 |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Earnings (loss) per common share:                |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Basic and diluted                                |  | $                                 | (0.24      | ) |                                   | $ | (0.19      | )                                 |  | $ | (0.43                                          | ) |  | $ | (2.03       | )
|                                                 |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  

The accompanying notes are an integral part of these financial statements.



F-5



---

##### Table of Contents

ImmunoCellular Therapeutics, Ltd.

(A Development Stage Company)

Statements of Shareholders Equity (Deficit)



|                                                                                                      |        |                 |      |        |              |   |        |                   |  |        |            |   |         |                                         |       |      |       |   |            |   |  |   |            |   |  |   |             |   |  |   |            |  
|----------------------------------------------------------------------------------------------------- | ------ | --------------- | ---- | ------ | ------------ | - | ------ | ----------------- |  | ------ | ---------- | - | ------- | --------------------------------------- | ----- | ---- | ----- | - | ---------- | - |  | - | ---------- | - |  | - | ----------- | - |  | - | ---------- | -
|                                                                                                      |        | Preferred Stock |      |        | Common Stock |   |        | AdditionalPaid-In |  |        | Promissory |   |         | DeficitAccumulatedDuring theDevelopment |       |      | Total |  
|                                                                                                      | Shares |                 |      | Amount |              |   | Shares |                   |  | Amount |            |   | Capital |                                         |       | Note |       |   | Stage      |   | 
|Initial capitalization at $0.00002 per share                                                          |        |                 |     |        |              | $ |       |                   |  |        | 6,256,500  |   |         | $                                       | 10    |      |       | $ | 87         |   |  | $ |           |   |  | $ |            |   |  | $ | 97         |  
|                                                                                                      |        |                 |      |        |              |   |        |                  
|Common stock issued for cash during 2004 at $0.00078 per share                                        |        |                 |     |        |              |   |       |                   |  |        | 193,500    |   |         |                                         | 15    |      |       |   | 135        |   |  |   |           |   |  |   |            |   |  |   | 150        |  
|Net loss                                                                                              |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   |           |   |  |   |           |   |  |   | (11,741     | ) |  |   | (11,741    | )
|                                                                                                      |        |                 |      |        |              |   |        |                   |  |        |            |   |         |                                         |       |      |       |   |            |   |  |   |            |   |  |   |             |   |  |   |            |  
|Balance at December 31, 2004                                                                          |        |                 |     |        |              |   |       |                   |  |        | 6,450,000  |   |         |                                         | 25    |      |       |   | 222        |   |  |   |           |   |  |   | (11,741     | ) |  |   | (11,494    | )
|                                                                                                      |        |                 |      |        |              |   |        |                  
|Common stock issued for cash during 2005 at $0.19 per share                                           |        |                 |     |        |              |   |       |                   |  |        | 387,000    |   |         |                                         | 659   |      |       |   | 74,341     |   |  |   |           |   |  |   |            |   |  |   | 75,000     |  
|Common stock issued for cash during 2005 at $0.32 per share                                           |        |                 |     |        |              |   |       |                   |  |        | 154,800    |   |         |                                         | 16    |      |       |   | 49,984     |   |  |   |           |   |  |   |            |   |  |   | 50,000     |  
|Common stock issued for research and development during 2005 at $0.99 per share                       |        |                 |     |        |              |   |       |                   |  |        | 154,800    |   |         |                                         | 15    |      |       |   | 152,745    |   |  |   |           |   |  |   |            |   |  |   | 152,760    |  
|Net loss                                                                                              |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   |           |   |  |   |           |   |  |   | (246,004    | ) |  |   | (246,004   | )
|                                                                                                      |        |                 |      |        |              |   |        |                   |  |        |            |   |         |                                         |       |      |       |   |            |   |  |   |            |   |  |   |             |   |  |   |            |  
|Balance at December 31, 2005                                                                          |        |                 |     |        |              |   |       |                   |  |        | 7,146,600  |   |         |                                         | 715   |      |       |   | 277,292    |   |  |   |           |   |  |   | (257,745    | ) |  |   | 20,262     |  
|                                                                                                      |        |                 |      |        |              |   |        |                  
|Common stock issued for services during 2006 at $0.50 per share                                       |        |                 |     |        |              |   |       |                   |  |        | 73,093     |   |         |                                         | 7     |      |       |   | 36,539     |   |  |   |           |   |  |   |            |   |  |   | 36,546     |  
|Common stock issued for cash during 2006 in private placements at $1.00 per share, net of redemptions |        |                 |     |        |              |   |       |                   |  |        | 1,510,000  |   |         |                                         | 151   |      |       |   | 549,249    |   |  |   |           |   |  |   |            |   |  |   | 549,400    |  
|Common stock issued for research and development during 2006 at $1.00 per share                       |        |                 |     |        |              |   |       |                   |  |        | 694,000    |   |         |                                         | 69    |      |       |   | 693,931    |   |  |   |           |   |  |   |            |   |  |   | 694,000    |  
|Shares issued in connection with reverse merger                                                       |        |                 |     |        |              |   |       |                   |  |        | 825,124    |   |         |                                         | 83    |      |       |   | (83        | ) |  |   |           |   |  |   |            |   |  |   |           |  
|Shares cancelled in connection with the sale of Optical Molecular Imaging, Inc.                       |        |                 |     |        |              |   |       |                   |  |        | (2,059,100 | ) |         |                                         | (206  | )    |       |   | (64,794    | ) |  |   |           |   |  |   |            |   |  |   | (65,000    | )
|Exercise of stock options                                                                             |        |                 |     |        |              |   |       |                   |  |        | 10,062     |   |         |                                         | 1     |      |       |   | 3,521      |   |  |   |           |   |  |   |            |   |  |   | 3,522      |  
|Stock based compensation (options)                                                                    |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   | 4,103,645  |   |  |   |           |   |  |   |            |   |  |   | 4,103,645  |  
|Net loss                                                                                              |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   |           |   |  |   |           |   |  |   | (5,152,713  | ) |  |   | (5,152,713 | )
|                                                                                                      |        |                 |      |        |              |   |        |                   |  |        |            |   |         |                                         |       |      |       |   |            |   |  |   |            |   |  |   |             |   |  |   |            |  
|Balance at December 31, 2006                                                                          |        |                 |     |        |              |   |       |                   |  |        | 8,199,779  |   |         |                                         | 820   |      |       |   | 5,599,300  |   |  |   |           |   |  |   | (5,410,458  | ) |  |   | 189,662    |  
|                                                                                                      |        |                 |      |        |              |   |        |                  
|Common stock issued for cash during 2007 in private placements at $1.50 per share                     |        |                 |     |        |              |   |       |                   |  |        | 3,531,603  |   |         |                                         | 353   |      |       |   | 4,892,133  |   |  |   |           |   |  |   |            |   |  |   | 4,892,486  |  
|Exercise of stock options                                                                             |        |                 |     |        |              |   |       |                   |  |        | 51,111     |   |         |                                         | 5     |      |       |   | (5         | ) |  |   |           |   |  |   |            |   |  |   |           |  
|Reclassification of warrant derivative liability                                                      |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   | 2,233,600  |   |  |   |           |   |  |   |            |   |  |   | 2,233,600  |  
|Stock based compensation (options)                                                                    |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   | 1,296,714  |   |  |   |           |   |  |   |            |   |  |   | 1,296,714  |  
|Net loss                                                                                              |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   |           |   |  |   |           |   |  |   | (3,614,753  | ) |  |   | (3,614,753 | )
|                                                                                                      |        |                 |      |        |              |   |        |                   |  |        |            |   |         |                                         |       |      |       |   |            |   |  |   |            |   |  |   |             |   |  |   |            |  
|Balance at December 31, 2007                                                                          |        |                 |     |        |              |   |       |                   |  |        | 11,782,493 |   |         |                                         | 1,178 |      |       |   | 14,021,742 |   |  |   |           |   |  |   | (9,025,211  | ) |  |   | 4,997,709  |  
|                                                                                                      |        |                 |      |        |              |   |        |                  
|Common stock issued for research and development during 2008 at $0.53 per share                       |        |                 |     |        |              |   |       |                   |  |        | 800,000    |   |         |                                         | 80    |      |       |   | 423,920    |   |  |   |           |   |  |   |            |   |  |   | 424,000    |  
|Common stock issued for research and development during 2008 at $0.65 per share                       |        |                 |     |        |              |   |       |                   |  |        | 100,000    |   |         |                                         | 10    |      |       |   | 64,990     |   |  |   |           |   |  |   |            |   |  |   | 65,000     |  
|Stock based compensation (options)                                                                    |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   | 513,357    |   |  |   |           |   |  |   |            |   |  |   | 513,357    |  
|Net loss                                                                                              |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   |           |   |  |   |           |   |  |   | (3,059,730  | ) |  |   | (3,059,730 | )
|                                                                                                      |        |                 |      |        |              |   |        |                   |  |        |            |   |         |                                         |       |      |       |   |            |   |  |   |            |   |  |   |             |   |  |   |            |  
|Balance at December 31, 2008                                                                          |        |                 |     |        |              |   |       |                   |  |        | 12,682,493 |   |         |                                         | 1,268 |      |       |   | 15,024,009 |   |  |   |           |   |  |   | (12,084,941 | ) |  |   | 2,940,336  |  
|                                                                                                      |        |                 |      |        |              |   |        |                  
|Exercise of warrants                                                                                  |        |                 |     |        |              |   |       |                   |  |        | 1,970,992  |   |         |                                         | 1,97  |      |       |   | 462,551    |   |  |   |           |   |  |   |            |   |  |   | 462,748    |  
|Exercise of stock options                                                                             |        |                 |     |        |              |   |       |                   |  |        | 214,357    |   |         |                                         | 22    |      |       |   | 64,460     |   |  |   | (52,668    | ) |  |   |            |   |  |   | 11,814     |  
|Stock based compensation (options)                                                                    |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   | 308,302    |   |  |   |           |   |  |   |            |   |  |   | 308,302    |  
|Net loss                                                                                              |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   |           |   |  |   |           |   |  |   | (2,626,205  | ) |  |   | (2,626,205 | )
|                                                                                                      |        |                 |      |        |              |   |        |                   |  |        |            |   |         |                                         |       |      |       |   |            |   |  |   |            |   |  |   |             |   |  |   |            |  
|Balance at December 31, 2009                                                                          |        |                 |     |        |              |   |       |                   |  |        | 14,867,842 |   |         |                                         | 1,487 |      |       |   | 15,859,322 |   |  |   | (52,668    | ) |  |   | (14,711,146 | ) |  |   | 1,096,995  |  
|                                                                                                      |        |                 |      |        |              |   |        |                  
|Common stock and warrants issued for cash during 2010 at $1.00 per share, net of offering costs       |        |                 |     |        |              |   |       |                   |  |        | 4,230,910  |   |         |                                         | 423   |      |       |   | 3,248,315  |   |  |   |           |   |  |   |            |   |  |   | 3,248,738  |  
|Preferred stock and warrants issued for cash during 2010 at $10,000 per share, net of offering costs  |        |                 | 400  |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   |           |   |  |   |           |   |  |   |            |   |  |   |           |  
|Exercise of warrants in exchange for promissory note                                                  |        |                 |     |        |              |   |       |                   |  |        | 2,700,000  |   |         |                                         | 270   |      |       |   | 5,399,730  |   |  |   | (5,400,000 | ) |  |   |            |   |  |   |           |  
|Redemption of preferred stock for repayment of promissory note                                        |        |                 | (400 | )      |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   |           |   |  |   | 5,400,000  |   |  |   | (2,092,500  | ) |  |   | 3,307,500  |  
|Exercise of stock options                                                                             |        |                 |     |        |              |   |       |                   |  |        | 50,000     |   |         |                                         | 5     |      |       |   | 26,495     |   |  |   |           |   |  |   |            |   |  |   | 26,500     |  
|Cashless exercise of stock options                                                                    |        |                 |     |        |              |   |       |                   |  |        | 297,156    |   |         |                                         | 30    |      |       |   | (30        | ) |  |   |           |   |  |   |            |   |  |   |           |  
|Common stock issued for services during 2010 at $0.90 per share                                       |        |                 |     |        |              |   |       |                   |  |        | 60,000     |   |         |                                         | 6     |      |       |   | 53,994     |   |  |   |           |   |  |   |            |   |  |   | 54,000     |  
|Common stock issued for services during 2010 at $1.06 per share                                       |        |                 |     |        |              |   |       |                   |  |        | 7,694      |   |         |                                         |      |      |       |   | 8,156      |   |  |   |           |   |  |   |            |   |  |   | 8,156      |  
|Stock based compensation                                                                              |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   | 745,697    |   |  |   |           |   |  |   |            |   |  |   | 745,697    |  
|Interest on promissory note                                                                           |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   |           |   |  |   | (1,614     | ) |  |   |            |   |  |   | (1,614     | )
|Net loss                                                                                              |        |                 |     |        |              |   |       |                   |  |        |           |   |         |                                         |      |      |       |   |           |   |  |   |           |   |  |   | (6,150,142  | ) |  |   | (6,150,142 | )
|                                                                                                      |        |                 |      |        |              |   |        |                   |  |        |            |   |         |                                         |       |      |       |   |            |   |  |   |            |   |  |   |             |   |  |   |            |  
|Balance at December 31, 2010                                                                          |        |                 |     |        |              | $ |       |                   |  |        | 22,213,602 |   |         | $                                       | 2,221 |      |       | $ | 25,341,679 |   |  | $ | (54,282    | ) |  | $ | (22,953,788 | ) |  | $ | 2,335,830  |  
|                                                                                                      |        |                 |      |        |              |   |        |                   |  |        |            |   |         |                                         |       |      |       |   |            |   |  |   |            |   |  |   |             |   |  |   |            |  

The accompanying notes are an integral part of these financial statements.



F-6



---

##### Table of Contents

ImmunoCellular Therapeutics, Ltd.

(A Development Stage Company)

Statements of Cash Flows



|                                                                                         |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|---------------------------------------------------------------------------------------- |  | --------------------------------- | ---------- | - | --------------------------------- | - | ---------- | --------------------------------- |  | - | ---------------------------------------------- | - |  | - | ----------- | -
|                                                                                         |  | For the YearEndedDecember 31,2008 |            |   | For the YearEndedDecember 31,2009 |   |            | For the YearEndedDecember 31,2010 |  |   | February 25,2004(Inception) toDecember 31,2010 |  
|Cash flows from operating activities:                                                    |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Net loss                                                                                 |  | $                                 | (3,059,730 | ) |                                   | $ | (2,626,205 | )                                 |  | $ | (6,150,142                                     | ) |  | $ | (20,861,288 | )
|Adjustments to reconcile net loss to net cash used in operating activities:              |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Depreciation and amortization                                                            |  |                                   | 2,075      |   |                                   |   | 3,397      |                                   |  |   | 3,633                                          |   |  |   | 9,105       |  
|Interest accrued on promissory note                                                      |  |                                   |           |   |                                   |   |           |                                   |  |   | (1,264                                         | ) |  |   | (1,264      | )
|Change in fair value of warrant liability                                                |  |                                   |           |   |                                   |   |           |                                   |  |   | 1,018,238                                      |   |  |   | 2,287,238   |  
|Stock based compensation                                                                 |  |                                   | 513,357    |   |                                   |   | 308,303    |                                   |  |   | 745,697                                        |   |  |   | 6,967,716   |  
|Common stock issued for services                                                         |  |                                   |           |   |                                   |   |           |                                   |  |   | 62,156                                         |   |  |   | 98,703      |  
|Common stock issued for research and development                                         |  |                                   | 489,000    |   |                                   |   |           |                                   |  |   |                                               |   |  |   | 1,335,760   |  
|Changes in assets and liabilities:                                                       |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Other assets                                                                             |  |                                   | (5,440     | ) |                                   |   | (24,951    | )                                 |  |   | (3,256                                         | ) |  |   | (63,288     | )
|Accounts payable                                                                         |  |                                   | 102,753    |   |                                   |   | 92,652     |                                   |  |   | (54,536                                        | ) |  |   | 171,065     |  
|Accrued liabilities                                                                      |  |                                   | 12,538     |   |                                   |   | 95,023     |                                   |  |   | 126,264                                        |   |  |   | 276,384     |  
|                                                                                         |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Net cash used in operating activities:                                                   |  |                                   | (1,945,447 | ) |                                   |   | (2,151,781 | )                                 |  |   | (4,253,560                                     | ) |  |   | (9,780,219  | )
|                                                                                         |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Cash flows from investing activities:                                                    |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Sale (purchase) of short-term investments, net                                           |  |                                   | (3,000,000 | ) |                                   |   | 1,924,097  |                                   |  |   | 1,075,903                                      |   |  |   |            |  
|Purchase of property and equipment                                                       |  |                                   | (10,087    | ) |                                   |   | (813       | )                                 |  |   | (10,572                                        | ) |  |   | (61,472     | )
|Cash paid for sale of OMI                                                                |  |                                   |           |   |                                   |   |           |                                   |  |   |                                               |   |  |   | (25,000     | )
|                                                                                         |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Net cash provided by (used in) investing activities:                                     |  |                                   | (3,010,087 | ) |                                   |   | 1,923,284  |                                   |  |   | 1,065,331                                      |   |  |   | (86,472     | )
|                                                                                         |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Cash flows from financing activities:                                                    |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Exercise of stock options                                                                |  |                                   |           |   |                                   |   | 11,812     |                                   |  |   | 26,500                                         |   |  |   | 41,834      |  
|Exercise of warrant                                                                      |  |                                   |           |   |                                   |   | 462,748    |                                   |  |   |                                               |   |  |   | 462,748     |  
|Proceeds from issuance of common stock under private placement, net of offering costs    |  |                                   |           |   |                                   |   |           |                                   |  |   | 4,370,994                                      |   |  |   | 10,777,480  |  
|Proceeds from issuance of preferred stock under private placement, net of offering costs |  |                                   |           |   |                                   |   |           |                                   |  |   | 3,779,158                                      |   |  |   | 3,779,158   |  
|Proceeds from issuance of common stock                                                   |  |                                   |           |   |                                   |   |           |                                   |  |   |                                               |   |  |   | 125,247     |  
|                                                                                         |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Net cash provided by financing activities                                                |  |                                   |           |   |                                   |   | 474,560    |                                   |  |   | 8,176,652                                      |   |  |   | 15,186,467  |  
|                                                                                         |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Increase in cash and cash equivalents                                                    |  |                                   | 4,955,534  |   |                                   |   | 246,063    |                                   |  |   | 4,988,423                                      |   |  |   | 5,319,776   |  
|Cash and cash equivalents at beginning of period                                         |  |                                   | (5,040,824 | ) |                                   |   | 85,290     |                                   |  |   | 331,353                                        |   |  |   |            |  
|                                                                                         |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Cash and cash equivalents at end of period                                               |  | $                                 | 85,290     |   |                                   | $ | 331,353    |                                   |  | $ | 5,319,776                                      |   |  | $ | 5,319,776   |  
|                                                                                         |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Supplemental cash flows disclosures:                                                     |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Interest expense paid                                                                    |  | $                                 |           |   |                                   | $ |           |                                   |  | $ |                                               |   |  | $ |            |  
|                                                                                         |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  
|Income taxes paid                                                                        |  | $                                 |           |   |                                   | $ |           |                                   |  | $ |                                               |   |  | $ |            |  
|                                                                                         |  |                                   |            |   |                                   |   |            |                                   |  |   |                                                |   |  |   |             |  

The accompanying notes are an integral part of these financial statements.



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ImmunoCellular Therapeutics, Ltd.

(A Development Stage Company)

Notes to Financial Statements

1. Nature of Organization and Development Stage
Operations

ImmunoCellular Therapeutics, Ltd. (the Company) is a development stage company that is seeking to develop and commercialize new
therapeutics to fight cancer using the immune system.

In February 2008, the Company entered into an Agreement with Molecular Discoveries LLC
(Molecular Discoveries), covering the Companys acquisition of certain monoclonal antibody related technology owned by Molecular Discoveries and completed the acquisition of the technology on that date. The Molecular Discoveries
agreement also was acknowledged and agreed to by Dr. Cohava Gelber, an inventor of the technology acquired by the Company under this agreement and an equity owner of Molecular Discoveries.

The technology acquired under the Molecular Discoveries agreement and now owned by the Company consists of (i) a platform technology referred to by
Molecular Discoveries as DIAAD for the potentially rapid discovery of monoclonal antibodies to detect and treat cancer and other chronic diseases and (ii) certain monoclonal antibody candidates for the potential detection and treatment of
multiple myeloma, small cell lung, pancreatic and ovarian cancers. The monoclonal antibodies are covered by issued patents and pending patent applications in the fields of multiple myeloma, small cell lung and ovarian cancers.

As provided in the Molecular Discoveries agreement, the consideration for the intellectual property and related assets comprising the technology acquired
by the Company consisted of (i) the issuance of 800,000 shares of the Companys common stock to Molecular Discoveries and (ii) the reimbursement by the Company to Molecular Discoveries or its managing member of $250,000 of previously
incurred patent expenses. Molecular Discoveries has agreed that it will not publicly resell more than 100,000 shares in any 90-day period.

Since the Companys inception on February 25, 2004, the Company has been primarily engaged in the acquisition of certain intellectual property,
together with development of its product candidates and the recent clinical testing activities for one of its vaccine product candidates, and has not generated any recurring revenues. As a result, the Company has incurred operating losses and, as of
December 31, 2010, the Company had an accumulated deficit of $22,953,788. The Company expects to incur significant research, development and administrative expenses before any of its products can be launched and recurring revenues generated.

2. Summary of Significant Accounting Policies

Development Stage Enterprise  We are a development stage enterprise as defined by Financial Accounting Standard Boards Topic 915, Accounting and Reporting by Development
Stage Enterprises. We are devoting substantially all our present efforts to research and development. All losses accumulated since inception are considered part of our development stage activities.

Liquidity  As of December 31, 2010, we had working capital of $4,896,360, compared to working capital of $1,053,438 as of December
31, 2009. The estimated cost of completing the development of either of our current vaccine product candidates and of obtaining all required regulatory approvals to market either of those product candidates is substantially greater than the amount
of funds we currently have available. However, we believe that our existing cash balances, together with the $8 million in proceeds, before offering costs, from our February 2011 private placement and potential proceeds under our preferred stock
purchase arrangement with Socius Capital Group, LLC, will be sufficient to fund our currently planned level of operations through at least the third quarter of 2012, although there is no assurance that such proceeds will be sufficient for this
purpose.

Cash and cash equivalents  The Company considers all highly liquid debt instruments with an original maturity of 90
days or less to be cash equivalents. As of December 31, 2009 and December 31, 2010, the Company had $0 and $4,500,000, respectively, of certificates of deposit with an original maturity of 90 days or less. These securities were fully
covered by FDIC insurance.

Short-Term Investments  As of December 31, 2009 and December 31, 2010, the Company had
$1,075,903 and $0, respectively, of certificates of deposit which mature within an original maturity of six months. These securities were fully covered by FDIC insurance. They are classified as held-to-maturity and under ASC Topic 320,
Investments in Debt Securities, are measured at cost since the Company has the intent and ability to hold these securities to maturity.

Property and Equipment  Property and equipment are stated at cost and depreciated using the straight-line methods based on the estimated useful lives (generally three to five years) of the
related assets. Computer and computer equipment are depreciated over 3 years. Management continuously monitors and



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evaluates the realizability of recorded long-lived assets to determine whether their carrying values have been impaired. The Company records impairment losses on long-lived assets used in
operations when events and circumstances indicate that the assets might be impaired and the nondiscounted cash flows estimated to be generated by those assets are less than the carrying amount of those assets. Any impairment loss is measured by
comparing the fair value of the asset to its carrying amount. Repairs and maintenance costs are expensed as incurred.

Research and
Development Costs  Research and development expenses consist of costs incurred for direct research and development and are expensed as incurred. On November 10, 2010, the Company received a grant under the Patent Protection and
Affordable Care Act of 2010. The grant, which totaled $244,479, will be used to fund ongoing projects, including the continued development of ICT-107 and was recorded as an offset to research and development costs for fiscal year end
December 31, 2010.

Stock Based Compensation  Stock-based compensation expense is estimated as of the grant date based on
the fair value of the award. The Company uses the Black-Scholes option pricing model to estimate the fair value of stock options and quoted market prices of our common stock to estimate fair value of restricted stock. The expected term is estimated
using the simplified method, as defined in Staff Accounting Bulletin No. 107. The risk free interest rate for each grant is equal to the U.S. Treasury rate in effect at the time of grant for instruments with an expected life similar to the
expected option term. Because of our limited trading history as a public company, the stock volatility assumption is based on an analysis of our historical volatility and the volatility of the common stock of comparable companies in the medical
industry and on the historical volatility of our stock. The dividend yield of zero is based upon the fact that we have not historically granted cash dividends, and do not expect to issue dividends in the foreseeable future.

The Company recognizes stock-based compensation expense over the requisite service period, which generally equals the vesting period. For awards that
vest based on employment, the Company recognizes the associated compensation expense on a straight-line basis. For performance based awards, the Company recognizes expense using the graded vesting methodology based on the number of shares expected
to vest. Compensation expense associated with these performance based awards is adjusted quarterly to reflect subsequent changes in the estimated outcome of performance-related conditions until the date the results are determined.

Fair value was estimated at the date of grant using the Black-Scholes pricing model, with the following weighted average assumptions:



|                        |  |                            |           |   |                            |  |           |                            |  |  |           |  
|----------------------- |  | -------------------------- | --------- | - | -------------------------- |  | --------- | -------------------------- |  |  | --------- | -
|                        |  | Year EndedDecember 31,2008 |           |   | Year EndedDecember 31,2009 |  |           | Year EndedDecember 31,2010 | 
|Risk-free interest rate |  |                            | 2.65      | % |                            |  | 1.40      | %                          |  |  | 1.24      | %
|Expected dividend yield |  |                            | None      |   |                            |  | None      |                            |  |  | None      |  
|Expected term           |  |                            | 3.9 years |   |                            |  | 3.8 years |                            |  |  | 3.7 years |  
|Expected volatility     |  |                            | 100.0     | % |                            |  | 118.0     | %                          |  |  | 102.0     | %

The weighted-average grant-date fair value
of options granted during the years ended December 31, 2008, 2009 and 2010 was $0.35, $0.32 and $0.62, respectively.

The risk-free
interest rate used in the Black-Scholes valuation method is based on the implied yield currently available in U.S. Treasury securities at maturity with an equivalent term. The Company has not declared or paid any dividends and does not currently
expect to do so in the future. The expected term of options represents the period that our stock-based awards are expected to be outstanding and was determined based on projected holding periods for the remaining unexercised shares. Consideration
was given to the contractual terms of our stock-based awards, vesting schedules and expectations of future employee behavior.



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Expected volatility is based on market prices of traded options for comparable entities within our industry and on the historical volatility of our stock.

The Companys stock price volatility and option lives involve managements best estimates, both of which impact the fair value of the option
calculated under the Black-Scholes methodology and, ultimately, the expense that will be recognized over the life of the option.

When options
are exercised, our policy is to issue previously unissued shares of common stock to satisfy share option exercises. As of December 31, 2010, the Company had 51.8 million shares of authorized but unissued common stock.

No tax benefits were attributed to the stock-based compensation expense because a valuation allowance was maintained for substantially all net deferred
tax assets.

Income Taxes  The Company accounts for federal and state income taxes in accordance with ASC Topic 740,
Accounting for Income Taxes. Under the liability method, a deferred tax asset or liability is determined based on the difference between the financial statement and tax basis of assets and liabilities, as measured by the enacted tax
rates. The Companys provision for income taxes represents the amount of taxes currently payable, if any, plus the change in the amount of net deferred tax assets or liabilities. A valuation allowance is provided against net deferred tax assets
if recoverability is uncertain on a more likely than not basis. FASB ASC 740, Income Taxes, (ASC 740), clarifies the accounting for uncertainty in income tax positions (tax positions). The provisions of ASC 740 require
the Company to recognize in its financial statements the impact of a tax position if the position will more likely than not be sustained upon examination by a taxing authority, based on the technical merits of the position. The Company periodically
analyzes its tax positions taken and expected to be taken and has determined that since inception there has been no need to record a liability for uncertain tax positions. The Company recognizes interest and penalties for uncertain tax positions in
income tax expense. There was no accrued interest or penalties related to uncertain tax positions as of December 31, 2008, 2009 or 2010. The Company is neither under examination by any taxing authority, nor has it been notified of an impending
examination. Due to the Companys recognition of losses since inception, all of the Companys reporting periods are effectively open to examination by the applicable taxing authorities.

Fair Value Measurements  The Company measures the fair value of financial assets and liabilities recorded at fair value based on the
guidance of ASC 820, Fair Value Measurements and Disclosures(ASC 820)which defines fair value, establishes a framework for measuring fair value, and expands disclosures about fair value measurements.

ASC 820 defines fair value as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or
most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. ASC 820 also establishes a fair value hierarchy, which requires an entity to maximize the use of observable inputs and
minimize the use of unobservable inputs when measuring fair value. ASC 820 describes three levels of inputs that may be used to measure fair value:

Level 1 - quoted prices in active markets for identical assets or liabilities

Level 2 - quoted prices for similar assets and liabilities in active markets or inputs that are observable

Level 3 - inputs that are unobservable (for example cash flow modeling inputs based on assumptions)

Warrant liabilities represent the only financial assets or liabilities recorded at fair value by the Company. The fair value of warrant liabilities are
determined based on Level 3 inputs.

Use of Estimates  The preparation of financial statements in conformity with accounting
principles generally accepted in the United States requires management to make certain estimates and assumptions about the future outcome of current transactions which may affect the reporting and disclosure of these transactions. Accordingly,
actual results could differ from those estimates used in the preparation of these financial statements.

Basic and Diluted Loss per Common
Share  Basic and diluted loss per common share are computed based on the weighted average number of common shares outstanding. Common share equivalents (which consist of options and warrants) are excluded from the computation of diluted
loss per share since the effect would be antidilutive. Common share equivalents which could potentially dilute basic earnings per share in the future, and which were excluded from the computation of diluted loss per share, totaled 16,113,917 shares,
10,555,927 shares and 12,358,018 shares at December 31, 2008, December 31, 2009 and December 31, 2010, respectively.

Recently Issued Accounting Standards Effective January 1, 2010, the Company adopted an accounting standard update regarding fair value
measurements. As codified under ASC 820, this update



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requires additional disclosures about fair value measurements including transfers in and out of Levels 1 and 2 and a higher level of disaggregation for the different types of financial
instruments. For the reconciliation of Level 3 fair value measurements, information about purchases, sales, issuances and settlements should be presented separately. Because this update addresses disclosure requirements, the adoption of this update
did not impact our financial position, results of operations or cash flows.

Reclassifications  Certain prior year items have
been reclassified to conform to current year presentation.

3. Property and Equipment

As of December 31, 2009 and December 31, 2010, $10,900 and $21,472 of equipment had been purchased, respectively. Depreciation expense was
$2,075, $3,397 and $3,633 for the years ended December 31, 2008, December 31, 2009 and December 31, 2010, respectively. Depreciation expense was $9,105 for the period from February 25, 2004 (date of inception) to
December 31, 2010.

4. Related-Party Transactions

Cedars-Sinai Medical Center License Agreement

In November 2006, the Company entered into a
license agreement with Cedars-Sinai Medical Center (Cedars-Sinai) under which the Company acquired an exclusive, worldwide license to its technology for use as cellular therapies, including cancer stem cell and dendritic cell-based
vaccines for neurological disorders that include brain tumors and neurodegenerative disorders and other cancers. This technology is covered by a number of pending U.S. and foreign patent applications, and the term of the license will be until the
last to expire of any patents that are issued covering this technology.

As an upfront licensing fee, the Company issued Cedars-Sinai 694,000
shares of its common stock and paid Cedars-Sinai $62,000. Additional specified milestone payments will be required to be paid to Cedars-Sinai when the Company initiates patient enrollment in its first Phase III clinical trial and when it
receives FDA marketing approval for its first product.

The Company has agreed to pay Cedars-Sinai specified percentages of all of its
sublicensing income and gross revenues from sales of products based on the licensed technology, subject to a reduction if it must make any payments to any third party whose proprietary rights would be infringed by sale of the products. To maintain
its rights to the licensed technology, the Company must meet certain development and funding milestones. These milestones include, among others, commencing a Phase I clinical trial for a product candidate by March 31, 2007 and raising at
least $5,000,000 in funding from equity or other sources by December 31, 2008. The Company satisfied the foregoing funding requirement in 2007 and commenced a Phase I clinical trial in May 2007, which was within the applicable cure period for
the milestone requirement. Through December 31, 2009, the Company has paid Cedars-Sinai a total of $166,660 in connection with the Phase I clinical trial. The Company also was required to commence a Phase II clinical trial for a
product candidate by December 31, 2008 and a waiver of this requirement was obtained from Cedars-Sinai (see Second Amendment below).

On
June 16, 2008, the Company entered into a First Amendment to Exclusive License Agreement (the Amendment) with Cedars-Sinai. The Amendment amended the License Agreement to include in the Companys exclusive license from
Cedars-Sinai under that agreement an epitope to CD133 and certain related intellectual property. This technology will be covered by a U.S. patent application that will be filed by the parties. Pursuant to the Amendment, the Company issued
Cedars-Sinai 100,000 shares of the Companys common stock as an additional license fee for the licensed CD133 epitope technology, which will be subject to the royalty and other terms of the License Agreement.



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On July 22, 2009, the Company entered into a Second Amendment to Exclusive License Agreement (the
Second Amendment) with Cedars-Sinai to become effective August 1, 2009. The Second Amendment amended the License Agreement to revise the milestones set forth in the License Agreement that the Company must achieve in order to
maintain its license rights under that agreement. The revised milestones include the replacement of a milestone that required commencement of a Phase II clinical trial for the Companys first product candidate by no later than December 31,
2008 with milestones that require commencement of a Phase I clinical trial for the Companys second product candidate by no later than June 30, 2010 and commencement of a Phase II clinical trial for one of the Companys product
candidates by no later than March 31, 2012.

Effective March 23, 2010, the Company entered into a Third Amendment to the Exclusive
License Agreement (the Third Amendment) with Cedars-Sinai. The Third Amendment amended the License Agreement to revise the milestones set forth in the License Agreement that the Company must achieve in order to maintain its license
rights under that agreement. The revised milestones include the replacement of a milestone that required commencement of a Phase I clinical trial for the Companys second product candidate by no later than June 30, 2010 and commencement of
a Phase II clinical trial for one of the Companys product candidates by no later than March 31, 2012 with a requirement that the Company by September 30, 2011 either commence a Phase II clinical trial for its dendritic cell
vaccine candidate or a Phase I clinical trial for its cancer stem cell vaccine candidate. The amendment also added a requirement that the Company obtain certain defined forms of equity or other funding in the amount of at least $2,500,000 by
December 31, 2010 and a total of at least $5,000,000 by September 30, 2011. These funding requirements were fully satisfied as of June 30, 2010.

On September 20, 2010, the Company entered into a sponsored research agreement with Cedars-Sinai to provide services to develop standard operating procedures for dendritic cell vaccine preparation
over the next twelve months for $446,142.

5. Commitments and Contingencies

Operating Lease

Effective March 1, 2010, the Company renewed its lease through
March 31, 2011 at a monthly rental rate of $2,779. In May 2010, the Company amended its lease to a monthly rental rate of $2,320 for three months and to a monthly rental rate of $2,894 for the remaining months through June 30, 2011. In
August 2010, the Company amended its lease to a monthly rental rate of $3,140 for September 2010 and to a monthly rental rate of $3,493 for the remaining months through June 30, 2011.

Employment Agreement with Dr. Manish Singh

On March 4, 2010, the Company entered
into an Employment Agreement, effective as of February 18, 2010, with Dr. Manish Singh pursuant to which Dr. Singh will continue to serve on a full-time basis as the Companys President and Chief Executive Officer for a one-year
term commencing February 18, 2010. The Company is required under the Employment Agreement to use its commercially reasonable efforts to have Dr. Singh continue to serve as a member of the Companys Board of Directors during the term
of the Employment Agreement. The Employment Agreement may be extended for an additional one-year period upon the mutual agreement of the Company and Dr. Singh.

The Employment Agreement provides for an annual base salary of $300,000. In addition, provided that Dr. Singh continues to serve as the Companys President and Chief Executive Officer for the
entire one-year term of the Employment Agreement, the Company will pay Dr. Singh a discretionary cash bonus of up to $50,000 upon completion of the one-year term.

The Employment Agreement dated as of February 18, 2009 between the Company and Dr. Singh (the Prior Agreement) provides that Dr. Singh is entitled to receive cash milestone
bonuses, not to exceed an



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aggregate amount of $200,000, of (i) $50,000 upon the Companys completion of a financing, a strategic alliance or a merger or acquisition generating at least $2,500,000 of net proceeds
(after commissions) during the term of the Prior Agreement, (ii) $100,000 upon the Companys completion of a financing, a strategic alliance or a merger or acquisition generating at least $5,000,000 of net proceeds (after commissions)
during the term of the Prior Agreement, or (iii) $200,000 upon the Companys completion of a financing, a strategic alliance or a merger or acquisition generating at least $10,000,000 of net proceeds (after commissions) during the term of
the Prior Agreement. The Prior Agreement also provides that an option granted to Dr. Singh to purchase 200,000 shares of the Companys common stock will vest if the Companys working capital is at least $8,000,000 at the end of the
term of the Prior Agreement.

The Employment Agreement amends the Prior Agreement to provide that the milestones described in the preceding
paragraph may be satisfied by including the net proceeds received by the Company at any time prior to August 17, 2010 from (i) a financing by the Socius Capital Group or (ii) any private placement financing that is covered by a signed
term sheet that was entered into by the Company prior to February 18, 2010 or from another source at the same or better terms as contemplated by such signed term sheet. Also, for purposes of determining whether the $8,000,000 working capital
milestone in the preceding paragraph has been satisfied, the Employment Agreement provides that working capital will be calculated as of the date of the Companys receipt of the proceeds that are being included to satisfy the milestone. This
funding milestone was fully satisfied as of June 30, 2010.

Pursuant to the Employment Agreement, the Company granted to Dr. Singh a
seven-year incentive stock option under the Companys 2006 Equity Incentive Plan (the Plan), or a new qualified option plan, to purchase 600,000 shares of the Companys common stock at an exercise price equal to $0.90 per
share, which was the closing market price of the common stock on the option grant date. The option grant was subject to the approval by the Companys stockholders of an increase in the authorized number of shares under the Plan and an increase
in the number of shares that may be granted to any individual during a 12-month period, which approval was subsequently obtained. The option may be exercised during the period that Dr. Singh provides services to the Company and for 24 months
after termination for any reason except termination for cause by the Company, provided that such exercise is within the seven-year term of the option.

The option granted to Dr. Singh under the Employment Agreement will vest (i) as to 360,000 shares, in 12 equal monthly installments of 30,000 shares each over the 12-month period from and
immediately following the grant date, (ii) as to 30,000 shares, if the Company achieves during the term of the Employment Agreement a volume-weighted average trading price for its common stock of greater than $1.60 for any consecutive 15-day
trading period during the term of the agreement on average daily trading volume of at least 20,000 shares, (iii) as to 90,000 shares, if the Company achieves during the term of the Employment Agreement a volume-weighted average trading price
for its common stock of greater than $2.00 for any consecutive 15-day trading period during the term of the agreement on average daily trading volume of at least 20,000 shares, (iv) as to 30,000 shares, upon treating the first patient in a
Phase II clinical trial, and (v) as to 90,000 shares, if during the term of the Employment Agreement the Company completes a financing, a strategic alliance or a licensing agreement with upfront licensing payments to the Company or a merger or
acquisition that generates at least $5,000,000 of net proceeds (after commissions) for the Company beyond the $10,000,000 achieved by August 17, 2010, with any financing proceeds received by the Company during the first 6 months of the
Employment Agreement that are used to satisfy milestones under the Prior Agreement not being included as proceeds to satisfy the milestones described in this paragraph.

In the event that the Company terminates the Employment Agreement without cause or does not extend the Employment Agreement upon its expiration for an additional one-year term, then (i) the Company
upon such termination will be required to make a lump sum payment to Dr. Singh equal to 6 months of his base annual salary, (ii) any stock options granted to Dr. Singh, to the extent vested, will be retained by Dr. Singh and will
be exercisable on the terms described above, and (iii) the vesting of an additional number of shares subject to all options granted to Dr. Singh equal to 50% of all shares subject to such options that have not already vested will
immediately accelerate and will be exercisable on the terms described above. If



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Dr. Singh terminates his employment for good reason as defined in the Employment Agreement, he will receive the severance benefits described in the preceding sentence, except
that 100% of his options will vest if his employment terminates for good reason following a merger or similar corporate transaction in which the Company is not the surviving entity.

Employment Agreement with Dr. James Bender

On March 4, 2010, the Company entered
into an Employment Agreement, effective as of February 1, 2010, with Dr. James Bender pursuant to which Dr. Bender will serve on a full-time basis as the Companys Vice President  Product Development and Manufacturing for a
one-year term commencing February 18, 2010. Prior to February 1, 2010, Dr. Bender had been serving on a part-time basis as the Companys Vice President  Clinical Development pursuant to an Agreement dated as of
September 1, 2009, as amended on September 14, 2009 (the Prior Agreement).

The Employment Agreement provides for an
annual base salary of $170,000. Pursuant to the Employment Agreement, the Company granted to Dr. Bender a seven-year incentive stock option under the Companys Plan to purchase 150,000 shares of the Companys common stock at an
exercise price equal to $0.90 per share, which was the closing market price of the common stock on the option grant date. The option grant was subject to the approval by the Companys stockholders of an increase in the authorized number of
shares under the Plan, which approval was subsequently obtained.

The option granted to Dr. Bender under the Employment Agreement will
vest at the rate of 6,250 shares per month over the term of the Employment Agreement as to 75,000 shares. The option will vest as to the remaining 75,000 shares upon the Companys attainment of the following development milestones, and
Dr. Bender will also be entitled to receive the following cash bonuses upon attainment of these milestones: (i) completion by September 30, 2010 of the technology transfer to a contract manufacturer for the Companys ICT-107
product will result in a $10,000 cash bonus and the vesting of 25,000 option shares; (ii) completion by December 31, 2010 of FDA acceptance of a Phase II clinical trial plan for ICT-107 will result in a $10,000 cash bonus and the vesting
of 25,000 option shares; and (iii) completion by December 31, 2010 of the enrollment of the first patient into the Phase II clinical trial for ICT-107 will result in a $10,000 bonus and the vesting of 25,000 option shares.

The Employment Agreement provides that all of the rights and obligations of the Company and Dr. Bender under the Prior Agreement (including
Dr. Benders right to work for another organization) terminated as of January 31, 2010, except that Dr. Benders right under the Prior Agreement to receive cash bonuses and the vesting of options upon the Companys
achievement of specified development milestones will remain in effect.

The Employment Agreement provides that, except as described in the
following sentence, if Dr. Benders employment terminates prior to the expiration of the one-year term, Dr. Bender will not have any right to receive further compensation under the Employment Agreement other than compensation that was
accrued as of his employment termination date. If the Company terminates Dr. Benders employment without cause as defined in the Employment Agreement, 50% of any unvested options held by Dr. Bender as of the employment
termination date will vest, and he will also have the right to receive any compensation that was accrued as of the employment termination date.

Agreement with Dr. John Yu

Effective March 1, 2010, the Company entered into an Agreement with Dr. Yu under which he agreed to serve on a part-time basis as the
Companys Chief Scientific Officer for a one-year term. The Agreement provides for an annual base salary of $70,000 and for cash bonuses of $15,000 each if prior to December 31, 2010 (i) the FDA has accepted a Phase II clinical
trial plan for ICT-107, and (ii) a Physicians Investigator IND submission for one of the Companys specified product candidates has been accepted by the FDA.



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Pursuant to the Agreement, the Company granted to Dr. Yu a seven-year nonqualified stock option under
the Companys 2006 Equity Incentive Plan to purchase 125,000 shares of the Companys common stock at an exercise price equal to $0.90 per share, which was the closing market price of the common stock on the option grant date. The option
grant was subject to the approval by the Companys stockholders of an increase in the authorized number of shares under the Plan, which approval was subsequently obtained. The option may be exercised during the period that Dr. Yu provides
services to the Company and for 24 months after termination for any reason except termination for cause by the Company, provided that such exercise is within the seven-year term of the option.

The option granted to Dr. Yu under the Agreement will vest (i) as to 75,000 shares in four equal quarterly installments following the date of
grant and (ii) as to the remaining 50,000 shares, 25,000 shares shall each vest upon timely satisfying the two milestones described above for the payment of cash bonuses to Dr. Yu.

Agreement with C. Kirk Peacock

Effective as of October 30, 2008, the Company renewed,
under similar terms, the consulting agreement with C. Kirk Peacock under which Mr. Peacock agreed to serve as Chief Financial Officer for a one-year term, subject to earlier termination by the Company or Mr. Peacock on 30 days notice.
Mr. Peacock will provide his services to the Company on a part-time basis. Under the agreement with Mr. Peacock, Mr. Peacock will be paid $8,000 per month and was granted an option to purchase 50,000 shares of common stock, which will
vest monthly over a one-year period, and exercisable within its term during the period Mr. Peacock provides services to the Company and for 24 months after the grantee ceases providing services for any reason other than termination by the
Company for cause. Effective May 2009, the consulting agreement dated October 30, 2008 with C. Kirk Peacock was amended to reduce the amount to be paid to $6,000 per month. No other terms of the agreement were changed.

Effective October 30, 2009, the Company renewed the Consulting Agreement with Mr. Peacock under which he will continue to serve on a part-time
basis as the Companys Chief Financial Officer for a one-year term. Under this agreement, Mr. Peacock receives a monthly salary of $6,000 and was granted a seven-year non-qualified option to purchase 56,000 shares of the Companys
common stock at a price of $0.80 per share, with 50,000 shares covered by such option to vest in equal monthly installments over the one-year term of the agreement and with 50% of any those then unvested option shares to become vested if
Mr. Peacocks services are terminated by the Company without cause.

Provided that by October 29, 2010, all of the
Companys internal documentation and internal testing necessary to subsequently complete the Companys Sarbanes-Oxley Section 404 audit has been finished, the Company will pay Mr. Peacock an additional $6,000 and a further 6,000
of his option shares will become vested. Due to the elimination of the Sarbanes-Oxley Section 404 audit requirement for smaller issuers, this milestone was not met.

Effective October 30, 2010, the Company renewed the Consulting Agreement with Mr. Peacock under which he will continue to serve on a part-time basis as the Companys Chief Financial Officer
for five months. Under this agreement, Mr. Peacock receives a monthly salary of $8,000 and was granted 19,231 shares of restricted common stock, with such shares to vest in equal monthly installments over the five-month term of the agreement
and with 100% of any unearned compensation to become payable and any unvested option shares to become vested if Mr. Peacocks services are terminated by the Company without cause.

Agreements for Financial Advisory Services

On October 1, 2010, the Company entered
into an agreement with JFS Investments to provide certain financial advisory services to the Company on a non-exclusive basis (the JFS Agreement). The Company will issue an aggregate of up to 144,000 shares of the Companys common
stock as follows: 24,000 shares to



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JFS Investments and 12,000 shares to Samel, LLC upon the signing of the JFS Agreement and 108,000 shares to be issued at the rate of 8,000 shares to JFS Investments and 4,000 shares to Samel, LLC
each month for months four through twelve following the signing of the JFS Agreement if the Agreement is in effect and has not been terminated by the Company as of that time. Pursuant to the JFS Agreement, the Company also granted three-year
warrants to purchase 80,000 shares of the Companys common stock at an exercise price of $1.00 per share to JFS Investments to vest as to 20,000 shares upon issuance and 6,667 shares on the first day of each of the fourth through the eleventh
months and 6,664 shares in the twelfth month and 40,000 shares to Samel, LLC to vest as to 10,000 shares upon issuance and 3,333 shares on the first day of each of the fourth through the eleventh months and 3,336 shares in the twelfth month.
Pursuant to the JFS Agreement, the Company also granted three-year warrants to purchase 80,000 shares of the Companys common stock at an exercise price of $2.00 per share to JFS Investments to vest as to 20,000 shares upon issuance and 6,667
shares on the first day of each of the fourth through the eleventh months and 6,664 shares in the twelfth month and 40,000 shares to Samel, LLC to vest as to 10,000 shares upon issuance and 3,333 shares on the first day of each of the fourth through
the eleventh months and 3,336 shares in the twelfth month. The vesting of each of the foregoing warrants will terminate in the event the JFS Agreement is terminated by the Company.

On October 1, 2010, the Company entered into an agreement with Garden State Securities Inc. (GSS) to provide certain financial advisory services to the Company on a non-exclusive basis
(the GSS Agreement). The Company will issue an aggregate of up to 96,000 shares of the Companys common stock as follows: 24,000 shares to GSS upon the signing of the GSS Agreement and 72,000 shares to be issued at the rate of 8,000
shares for months four through twelve following the signing of the GSS Agreement if the GSS Agreement is in effect and has not been terminated by the Company as of that time. Pursuant to the GSS Agreement, the Company also granted a three-year
warrant to purchase 80,000 shares of the Companys common stock at an exercise price of $1.00 per share to GSS to vest as to 20,000 shares upon issuance and 6,667 shares on the first day of each of the fourth through the eleventh months and
6,664 shares in the twelfth month. Pursuant to the GSS Agreement, the Company also granted a three-year warrant to purchase 80,000 shares of the Companys common stock at an exercise price of $2.00 per share to vest as to 20,000 shares upon
issuance and 6,667 shares on the first day of each of the fourth through the eleventh months and 6,664 shares in the twelfth month. The vesting of each of the foregoing warrants will terminate in the event the GSS Agreement is terminated by the
Company.

Research and Development

In connection with the Cedars-Sinai Medical Center License Agreement, the Company has certain commitments as described in Note 4.

In August 2010, the Company entered into a master service agreement with Averion International Corporation, a clinical research contract organization (Averion), to provide us with services in
connection with our planned Phase II clinical study for our dendritic cell-based cancer vaccine product candidate for the treatment of glioblastoma at an estimated total cost for such services during the course of the trial of approximately $3.5
million over the next three years.

6. Shareholders Equity

Common Stock

In March 2010, the Company raised $1,654,686 (after commissions and offering
expenses) from the sale of 1,740,000 shares of common stock and warrants to purchase 696,000 shares of common stock at an exercise price of $1.15 per share, to various investors in a private placement. (See Warrants and Warrant
Liabilities below.)

In May 2010, the Company raised $2,716,308 (after commissions and offering expenses) from the sale of 2,490,910
shares of common stock and warrants to purchase 1,245,455 shares of common stock at an



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exercise price of $1.50 per share, to various investors in a private placement. (See Warrants and Warrant Liabilities below)

Preferred Stock

On December 3, 2009, the Company entered into a Preferred Stock
Purchase Agreement dated as of December 3, 2009 (the Preferred Stock Agreement) with Socius Capital Group, LLC, a Delaware limited liability company d/b/a Socius Life Sciences Capital Group, LLC (the Investor). Pursuant
to the Preferred Stock Agreement, the Company will issue to the Investor up to $10,000,000 of the Companys newly created Series A Preferred Stock (the Preferred Stock). The purchase price of the Preferred Stock is $10,000 per
share. The shares of Preferred Stock that are issued to the Investor will bear a cumulative dividend of 10.0% per annum, payable in shares of Preferred Stock, will be redeemable under certain circumstances and will not be convertible into
shares of the Companys common stock. Subject to the terms and conditions of the Preferred Stock Agreement, the Company has the right to determine (1) the number of shares of Preferred Stock that it will require the Investor to purchase
from the Company, up to a maximum purchase price of $10,000,000, (2) whether it will require the Investor to purchase Preferred Stock in one or more traunches, and (3) the timing of such required purchase or purchases of Preferred Stock.

The terms of the Preferred Stock are set forth in a Certificate of Designations of Preferences, Rights and Limitations of Series A Preferred
Stock that the Company filed with the Delaware Secretary of State on December 3, 2009.

Pursuant to the Preferred Stock Agreement, the
Company agreed to pay the Investor a commitment fee of $500,000 (the Commitment Fee), with $250,000 payable when the Company makes its first election to require the Investor to purchase shares of Preferred Stock and with the remaining
$250,000 payable when the aggregate amount of Preferred Stock purchased by the Investor equals at least $5,000,000; provided, however, that the first $250,000 portion of the Commitment Fee will be due and payable on the six-month anniversary of the
effective date of the registration statement described below even if no sales of Preferred Stock to the Investor have occurred by that date. The Company has the right to elect to pay each installment of the Commitment Fee in immediately available
funds or by issuance of shares of common stock. In January 2010, the Company accrued $250,000 in commitment fees associated with the Preferred Stock Agreement.

Concurrently with its execution of the Preferred Stock Agreement, the Company issued to the Investor a warrant (the Warrant) to purchase shares of common stock with an aggregate exercise price
of up to $13,500,000 depending upon the amount of Preferred Stock that is purchased by the Investor. Each time that the Company requires the Investor to purchase shares of Preferred Stock, a portion of the Warrant will become exercisable by the
Investor over a five-year period for a number of shares of common stock equal to (1) the aggregate purchase price payable by the Investor for such shares of Preferred Stock multiplied by 135%, with such amount divided by (2) the per share
Warrant exercise price. The initial exercise price under the Warrant is $1.04 per share of common stock. Thereafter, the exercise price for each portion of the Warrant that becomes exercisable upon the Companys election to require the Investor
to purchase Preferred Stock will equal the closing price of the common stock on the date that the Company delivers its election notice. The Investor is entitled to pay the Warrant exercise price in immediately available funds, by delivery of a
secured promissory note or, if a registration statement covering the resale of the common stock subject to the Warrant is not in effect, on a cashless basis.

Pursuant to the Preferred Stock Agreement, the Company agreed to file with the Securities and Exchange Commission a registration statement covering the resale of the shares of common stock that are
issuable to the Investor under the Warrant and in satisfaction of the Commitment Fee. The registration statement was deemed effective on January 22, 2010. The 1.2 million shares of common stock registered for the Commitment Fee are held in
escrow by the Company.



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On May 2, 2010, the Company issued and sold 400 shares of the Preferred Stock to Socius Capital Group,
LLC pursuant to the terms of the Preferred Stock Agreement. The aggregate purchase price for the Preferred Stock was $4,000,000 (less $220,842 in Commitment Fees and offering expenses). Under the terms of the Preferred Stock Agreement, Socius
remains obligated, from time to time until December 3, 2012, to purchase up to an additional 600 shares of Preferred Stock at a purchase price of $10,000 per share upon notice from the Company to Socius, and subject to the satisfaction of
certain conditions, as set forth in the Preferred Stock Agreement.

In connection with the foregoing transaction, a portion of the warrants
held by an affiliate of Socius became vested and exercisable covering 2,700,000 shares of the Companys common stock for a five-year period at an exercise price of $2.00 per share under the terms of the Preferred Stock Agreement. In
consideration of Socius agreeing to grant the Company certain waivers under the Preferred Stock Agreement, this affiliate also became entitled to purchase up to an additional 1,350,000 shares of the Companys common stock at an exercise price
of $2.50 per share. On May 2, 2010, the affiliate of Socius exercised a portion of its warrant for 1,675,000 shares and paid the $3,350,000 exercise price for these shares by delivering a four-year full recourse promissory note for this amount,
as permitted by the Preferred Stock Agreement. The Company immediately thereafter redeemed approximately 248 shares of the Preferred Stock by offsetting the $3,350,000 redemption price for these shares against the $3,350,000 owed to the Company
under the note. On December 2, 2010, the affiliate of Socius exercised the remaining portion of its warrant for 1,025,000 shares and paid the $2,050,000 exercise price for these shares by delivering a four-year full recourse promissory note for
this amount, as permitted by the Preferred Stock Agreement. The Company immediately thereafter redeemed approximately 152 shares of the Preferred Stock by offsetting the $2,050,000 redemption price for these shares against the $2,050,000 owed to the
Company under the note. (See Warrants and Warrant Liabilities below.)

Stock Options

In February 2005, the Company adopted an Equity Incentive Plan (Plan). Pursuant to the Plan, a committee appointed by the Board of Directors
may grant, at its discretion, qualified or nonqualified stock options, stock appreciation rights and may grant or sell restricted stock to key individuals, including employees, nonemployee directors, consultants and advisors. Option prices for
qualified incentive stock options (which may only be granted to employees) issued under the plan may not be less than 100% of the fair market value of the common stock on the date the option is granted (unless the option is granted to a person who,
at the time of grant, owns more than 10% of the total combined voting power of all classes of stock of the Company; in which case the option price may not be less than 110% of the fair market value of the common stock on the date the option is
granted). Option prices for nonqualified stock options issued under the Plan are at the discretion of the committee and may be equal to, greater or less than fair market value of the common stock on the date the option is granted. The options vest
over periods determined by the Board of Directors and are exercisable no later than ten years from date of grant (unless they are qualified incentive stock options granted to a person owning more than 10% of the total combined voting power of all
classes of stock of the Company, in which case the options are exercisable no later than five years from date of grant). As of December 31, 2010, the Company has reserved 6,000,000 shares of common stock for issuance under the Plan and options
to purchase 3,761,421 common shares have been granted under the Plan that are currently outstanding.

The following is a summary of stock
option grants issued outside the Plan:

In January 2007, the Company granted an option to purchase 1,500,000 shares of its common stock at an
exercise price of $1.10 per share to the Chairman of the Companys Scientific Advisory Board.

In November 2006, the Company granted an
option to purchase 300,000 shares of its common stock at an exercise price of $1.00 per share to an affiliate of the Companys then Chairman of the Board.



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In November 2006, the Company granted an option to purchase 5,933,424 shares of its common stock at an
exercise price of $1.00 per share to a Board member in connection with the Cedars-Sinai license acquisition.

The following table summarizes
stock option activity for the Company during the twelve months ended December 31, 2010:



|                                                |  |         |            |   |                              |   |      |                                         |  |  |                         |  |  |   |           | 
|----------------------------------------------- |  | ------- | ---------- | - | ---------------------------- | - | ---- | --------------------------------------- |  |  | ----------------------- |  |  | - | --------- | 
|                                                |  | Options |            |   | WeightedAverageExercisePrice |   |      | WeightedAverageRemainingContractualTerm |  |  | AggregateIntrinsicValue | 
|Outstanding December 31, 2007                   |  |         | 8,645,084  |   |                              | $ | 1.02 |                                         |  |  |                         |  |  |   |           | 
|Granted                                         |  |         | 1,100,000  |   |                              | $ | 0.77 |                                         |  |  |                         |  |  |   |           | 
|Exercised                                       |  |         |           |   |                              | $ |     |                                         |  |  |                         |  |  |   |           | 
|Forfeited or expired                            |  |         | (43,750    | ) |                              | $ | 0.86 |                                         |  |  |                         |  |  |   |           | 
|                                                |  |         |            |   |                              |   |      |                                         |  |  |                         |  |  |   |           | 
|Outstanding December 31, 2008                   |  |         | 9,701,334  |   |                              | $ | 0.99 |                                         |  |  |                         |  |  |   |           | 
|Granted                                         |  |         | 1,494,822  |   |                              | $ | 0.43 |                                         |  |  |                         |  |  |   |           | 
|Exercised                                       |  |         | (509,229   | ) |                              | $ | 0.69 |                                         |  |  |                         |  |  |   |           | 
|Forfeited or expired                            |  |         | (131,000   | ) |                              | $ | 0.93 |                                         |  |  |                         |  |  |   |           | 
|                                                |  |         |            |   |                              |   |      |                                         |  |  |                         |  |  |   |           | 
|Outstanding December 31, 2009                   |  |         | 10,555,927 |   |                              | $ | 0.92 |                                         |  |  |                         |  |  |   |           | 
|Granted                                         |  |         | 1,347,500  |   |                              | $ | 0.91 |                                         |  |  |                         |  |  |   |           | 
|Exercised                                       |  |         | (455,332   | ) |                              | $ | 0.39 |                                         |  |  |                         |  |  |   |           | 
|Forfeited or expired                            |  |         | (353,250   | ) |                              | $ | 1.04 |                                         |  |  |                         |  |  |   |           | 
|                                                |  |         |            |   |                              |   |      |                                         |  |  |                         |  |  |   |           | 
|Outstanding December 31, 2010                   |  |         | 11,094,845 |   |                              | $ | 0.94 |                                         |  |  | 5.6                     |  |  | $ | 4,690,490 | 
|                                                |  |         |            |   |                              |   |      |                                         |  |  |                         |  |  |   |           | 
|Vested or expected to vest at December 31, 2010 |  |         | 10,488,096 |   |                              | $ | 0.94 |                                         |  |  | 5.9                     |  |  | $ | 4,432,825 | 
|                                                |  |         |            |   |                              |   |      |                                         |  |  |                         |  |  |   |           | 

As of December 31, 2010, the total unrecognized compensation cost related to unvested stock options amounted to
$448,481, which will be amortized over the weighted-average remaining requisite service period of less than one year.

Warrants

In connection with the March 2010 common stock private placement, the Company issued to the investors warrants to purchase 696,000 shares
of the Companys common stock at $1.15 per share. The warrants have a term of 26 months from the date of issuance. On December 31, 2010, warrants to purchase 696,000 shares of the Companys common stock were outstanding related to
this private placement. (See Warrant Liabilities below.)

In connection with the May 2010 common stock private placement, the
Company issued to the investors warrants to purchase 1,245,455 shares of the Companys common stock at $1.50 per share. The warrants have a term of 36 months from the date of issuance. On December 31, 2010, warrants to purchase 1,245,455
shares of the Companys common stock were outstanding related to this private placement. (See Warrant Liabilities below.)

In
connection with the May 2010 Preferred Stock sale, the Company issued warrants to purchase 2,700,000 shares of common stock at an exercise price of $2.00 held by an affiliate of Socius. The warrants



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have a term of five-year from the date of issuance. In consideration of Socius agreeing to grant the Company certain waivers under the Preferred Stock Purchase Agreement, this affiliate also
became entitled to purchase up to an additional 1,350,000 shares of the Companys common stock at an exercise price of $2.50 per share. In May 2010, the affiliate of Socius exercised a portion of its warrant for 1,675,000 shares and paid the
$3,350,000 exercise price for these shares by delivering a four-year full recourse promissory note for this amount, as permitted by the Preferred Stock Purchase Agreement. The Company immediately thereafter redeemed approximately 248 shares of the
Preferred Stock by offsetting the $3,350,000 redemption price for these shares against the $3,350,000 owed to the Company under the note. In December 2010, the affiliate of Socius exercised the remaining portion of its warrant for 1,025,000 shares
and paid the $2,050,000 exercise price for these shares by delivering a four-year full recourse promissory note for this amount, as permitted by the Preferred Stock Purchase Agreement. The Company immediately thereafter redeemed approximately 152
shares of the Preferred Stock by offsetting the $2,050,000 redemption price for these shares against the $2,050,000 owed to the Company under the note. On December 31, 2010, no warrants to purchase of the Companys common stock at $2.00
were outstanding and warrants to purchase 1,350,000 shares of the Companys common stock at $2.50 were outstanding related to this private placement. (See Warrant Liabilities below.)

In connection with an investor relations agreement in December 2010, the Company issued a two-year warrant to purchase 50,000 shares of the
Companys common stock at an exercise price of $1.60.

In January 2009, the Company delivered notice to warrant holders in connection
with the reduction from $2.50 to $0.25 per share of the exercise price of warrants to purchase a total of 6,112,583 shares of the Companys common stock and in connection with the extension of the expiration date of warrants to purchase a total
of 6,412,583 shares of the Companys common stock from earlier dates in 2009 to June 30, 2009. The Company valued the warrant modification at $611,258, using the Black-Scholes pricing model and the following assumptions: contractual term
of 0.45 years, an average risk-free interest rate of 0.29% a dividend yield of 0% and volatility of 118%. In the footnotes to the Companys financial statements included in the Companys Annual Report on Form 10-K for the year ended
December 31, 2008, the Company disclosed that it anticipated taking a non-cash charge of approximately $500,000 in the first quarter of 2009. In the first quarter 2009, the Company determined that the warrant modification should be treated as a
dividend in-kind and not a non-cash charge, and since the Company was in a deficit position at the time of the modification, no dividend was recorded.

On June 30, 2009, the Company issued 1,970,992 shares of its common stock to 58 purchasers upon their exercise of warrants. The exercise price of 1,670,992 shares was $0.25 per share, and the
exercise price of 300,000 shares was $0.15 per share. The Company received an aggregate purchase price of $462,748, and the Company did not pay any underwriting discounts or commissions in the transaction. As of December 31, 2009, the Company
had no outstanding stock purchase warrants issued to investors.

Warrant Liabilities

In connection with the March 2010 common stock private placement, the Company issued to the investors warrants to purchase 696,000 shares of the
Companys common stock at $1.15 per share. Of the total proceeds from the March 2010 common stock private placement, $257,520 was allocated to the freestanding warrants associated with the units based upon the fair value of the warrants
determined under the Black Scholes option pricing model. The warrants contain a provision whereby the warrant exercise price would be decreased in the event that certain future common stock issuances are made at a price less than $1.00.

Under ASC 815 Derivatives and Hedging, the March 2010 warrants do not qualify for equity treatment due to the potential variability of their
exercise price, and therefore are recognized as a liability. The warrant liability will be adjusted to fair value each reporting period, and any changes in value will be recognized in the statement of operations. The warrants contain a provision
whereby the warrant exercise price would be decreased in the event that certain future common stock issuances are made at a price less than $1.00. We have concluded that the value of the conversion feature does not materially differ from the
valuation of such warrants using the Monte Carlo or lattice simulation models, and therefore the use of the Black-Scholes valuation model is considered a reasonable method to value the warrants. The assumptions used in the Black Scholes model for
determining the initial fair value of the warrants were as



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follows: (i) dividend yield of 0%; (ii) expected volatility of 102%, (iii) risk-free interest rate of 1.00%, and (iv) contractual life of 26 months. For the year ended
December 31, 2010, the Company recorded an other expense charge for the change in fair value of warrant liability of $215,760, with a carrying value of $473,280 at December 31, 2010.

In connection with the May 2010 common stock private placement, the Company issued to the investors warrants to purchase 1,245,455 shares of the
Companys common stock at $1.50 per share. Of the total proceeds from the May 2010 common stock private placement, $834,455 was allocated to the freestanding warrants associated with the units based upon the fair value of the warrants
determined under the Black Scholes option pricing model. The warrants contain a provision whereby the warrant exercise price would be decreased in the event that certain future common stock issuances are made at a price less than $1.00.

Under ASC 815 Derivatives and Hedging, the May 2010 warrants do not qualify for equity treatment due to the potential variability of their
exercise price, and therefore are recognized as a liability. The warrant liability will be adjusted to fair value each reporting period, and any changes in value will be recognized in the statement of operations. The warrants contain a provision
whereby the warrant exercise price would be decreased in the event that certain future common stock issuances are made at a price less than $1.00. We have concluded that the value of the conversion feature does not materially differ from the
valuation of such warrants using the Monte Carlo or lattice simulation models, and therefore the use of the Black-Scholes valuation model is considered a reasonable method to value the warrants. The assumptions used in the Black Scholes model for
determining the initial fair value of the warrants were as follows: (i) dividend yield of 0%; (ii) expected volatility of 102%, (iii) risk-free interest rate of 1.375%, and (iv) contractual life of 36 months. For the year ended
December 31, 2010, the Company recorded an other income charge for the change in fair value of warrant liability of $99,636 with a carrying value of $934,091 at December 31, 2010.

In connection with the May 2010 Preferred Stock sale, the Company vested warrants to purchase 2,700,000 shares of common stock at an exercise price of $2.00 held by an affiliate of Socius and issued
warrants to purchase an additional 1,350,000 shares of the Companys common stock at an exercise price of $2.50 per share. Of the total proceeds from the May 2010 preferred stock sale, $5,710,500 was allocated to the freestanding warrants
associated with the units based upon the fair value of these warrants determined under the Black Scholes option pricing model. The excess of the value of the freestanding warrants over the net proceeds of $1,931,342 was charged to change in fair
value of warrant liability in the statement of operations. The warrants contain a provision whereby the warrant may be settled for cash in connection with a change of control with a private company. In May 2010, the affiliate of Socius exercised a
portion of its warrant for 1,675,000 shares, which reduced warrant liabilities by $2,395,250. In December 2010, the affiliate of Socius exercised a portion of its warrant for 1,025,000 shares, which reduced warrant liabilities by $912,250.

Under ASC 815 Derivatives and Hedging, the May 2010 Preferred Stock warrants do not qualify for equity treatment, and are
recognized as a liability. The warrant liability will be adjusted to fair value each reporting period, and any changes in value will be recognized in the statement of operations. The warrants contain a provision whereby the warrant may be settled
for cash in connection with a change of control with a private company. Since settlement feature included in the warrant agreement is calculated using the Black-Scholes valuation model, the Company uses the Black-Scholes valuation model to value the
warrants. The assumptions used in the Black Scholes model for determining the initial fair value of the warrants were as follows: (i) dividend yield of 0%; (ii) expected volatility of 102%, (iii) risk-free interest rate of 2.50%, and
(iv) contractual life of 60 months. For the year ended December 31, 2010, the Company recorded an other income charge for the change in fair value of warrant liability of $1,228,500, with a carrying value of $1,174,500 at December 31,
2010.

The following is a reconciliation of the beginning and ending balances for warrant liabilities measured at fair value on a recurring
basis using significant unobservable inputs (Level 3) during the period ended December 31, 2010:



|                                    |  |                    |            |  
|----------------------------------- |  | ------------------ | ---------- | -
|                                    |  | WarrantLiabilities |           
|Balance  January 1, 2010           |  | $                  |           |  
|Issuance of warrants                |  |                    | 6,907,609  |  
|Exercise of warrants                |  |                    | (3,307,500 | )
|(Gain) or Loss included in earnings |  |                    | (1,018,238 | )
|Transfers in and/or out of Level 3  |  |                    |           |  
|                                    |  |                    |            |  
|Balance  December 31, 2010         |  | $                  | 2,581,871  |  
|                                    |  |                    |            |  

Promissory Note

In October 2009, the Companys former President exercised stock options for 150,479 shares of common stock and as provided under the stock option agreement provided the Company with a full recourse



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five-year promissory note bearing interest of 2.59% per annum. The promissory note is secured by a pledge of shares being acquired with all proceeds of any sale to be applied first to retire
in full the promissory note. The Company recorded the promissory note as an offset against shareholders equity. For the year ended December 31, 2010, the Company recorded interest income of $1,614.

7. Income Taxes

Deferred taxes
represent the net tax effects of the temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes. Temporary differences result primarily from the recording of tax benefits of net operating loss carry
forwards and start-up costs that will be amortized for tax purposes once the Company begins doing business as defined by the Internal Revenue Code.

As of December 31, 2010, the Company has an insufficient history to support the likelihood of ultimate realization of the benefit associated with the deferred tax asset. Accordingly, a valuation
allowance has been established for the full amount of the net deferred tax asset.

The Companys effective income tax rate differs from
the amount computed by applying the federal statutory income tax rate to loss before income taxes as follows:



|                                                      |  |      |     |    |      |  |     |      |  |  |     |   
|----------------------------------------------------- |  | ---- | --- | -- | ---- |  | --- | ---- |  |  | --- | --
|                                                      |  | 2008 |     |    | 2009 |  |     | 2010 | 
|Income tax benefit at the federal statutory rate      |  |      | (34 | %) |      |  | (34 | %)   |  |  | (34 | %)
|State income tax benefit, net of federal tax benefit  |  |      | (6  | %) |      |  | (6  | %)   |  |  | (6  | %)
|Change in fair value of warrant liability             |  |      |    |    |      |  |    |      |  |  | (7  | %)
|Change in valuation allowance for deferred tax assets |  |      | 40  | %  |      |  | 40  | %    |  |  | 47  | % 
|                                                      |  |      |     |    |      |  |     |      |  |  |     |   
|Total                                                 |  |      |    |    |      |  |    |      |  |  |    |   
|                                                      |  |      |     |    |      |  |     |      |  |  |     |   

Deferred taxes consisted of the following:



|                                 |  |                  |            |   |                  |   |            |  
|-------------------------------- |  | ---------------- | ---------- | - | ---------------- | - | ---------- | -
|                                 |  | December 31,2009 |            |   | December 31,2010 |  
|Net operating loss carryforwards |  |                  | $2,888,051 |   |                  | $ | 4,617,671  |  
|Stock-based compensation         |  |                  | 2,488,808  |   |                  |   | 2,811,949  |  
|Less valuation allowance         |  |                  | (5,376,859 | ) |                  |   | (7,429,620 | )
|                                 |  |                  |            |   |                  |   |            |  
|Net deferred tax asset           |  | $                |           |   |                  | $ |           |  
|                                 |  |                  |            |   |                  |   |            |  

At December 31, 2009 and December 31, 2010, the Company had approximately $7,220,127 and $11,544,178,
respectively, of net operating loss carryforwards. Due to our equity financing transactions, and other owner shifts as defined in Section 382 of the Internal Revenue Code of 1986, as amended, or the Code, we incurred ownership
changes pursuant to the Code. Accordingly, our use of net operating loss carryforwards is limited. We are currently studying the impact of Section 382 on the future realization of our various tax attributes. Such losses expire in 2024
through 2030 as of December 31, 2010. The utilization of the carryforwards is dependent upon the Companys ability to generate sufficient taxable income during the carryforward period.

As of the date of adoption of ASC 740 and the years ended December 31, 2010, 2009 and 2008, the tax returns for 2008 through 2010 remain open to
examination by the Internal Revenue Service and state tax authority.

8. Comprehensive Loss

For the year ended December 31, 2010, there was no other comprehensive loss and accordingly a Statement of Other Comprehensive Loss has not been
presented. Comprehensive income would normally include: foreign currency translation adjustments, a change in the market value of a futures contract that qualifies as a hedge of an asset reported at fair value, a net loss recognized as an additional
pension liability not yet recognized as net periodic pension cost, and unrealized holding gains and losses on available-for-sale securities.

9. Subsequent Events

Private
Placement

In February 2011, the Company raised $8,090,664 (before commissions and offering expenses) from the sale of 5,219,768 shares of
common stock and warrants to purchase 2,609,898 shares of common stock at an exercise price of $2.25 per share, to various investors in a private placement. The warrants have a term of



F-22



---

##### Table of Contents

60 months from the date of issuance. As a result of the Financing Transaction, the Company at the Closing issued to Summer Street Research Partners and Dawson James Securities, Inc.
(collectively, the Placement Agents), who served as the placement agents for the Financing Transactions, warrants to purchase up to 208,791 shares of Common Stock (the Placement Agent Warrants) on the same terms and
conditions as the Investor Warrants and paid a commission of $566,345 to the Placement Agents as well as certain of their expenses.

Sponsored Research and Vaccine Production Agreement

In January 2011, the Company entered in to a Sponsored Research and Vaccine Production Agreement with the University of Pennsylvania extending our existing sponsored research agreement with that
institution and providing certain manufacturing services for ICT-107 vaccine for use in our Phase II clinical trial.

Research Agreement

In January 2011, the Company amended the agreement with Averion to provide additional services in connection with our planned Phase II
clinical study for our dendritic cell-based cancer vaccine product candidate for the treatment of glioblastoma for an additional cost of $469,807.



F-23



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##### Table of Contents

Exhibit Index



|              |  |                                                                                                                                                                                                                                                                                              
|------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description                                                                                                                                                                                                                                                                                  
|              | 
|2.1           |  | Agreement and Plan of Reorganization dated as of May 5, 2005, as amended, among Patco Industries Subsidiary, Inc., William C. Patridge, and Spectral Molecular Imaging, Inc., as
amended on June 30, 2005, September 26, 2005 and January 20, 2006. (1)                                      
|              | 
|3.1           |  | Amended and Restated Certificate of Incorporation of ImmunoCellular Therapeutics, Ltd. (2)                                                                                                                                                                                                   
|              | 
|3.2           |  | Certificate of Amendment to Amended and Restated Certificate of Incorporation of ImmunoCellular Therapeutics, Ltd. (2)                                                                                                                                                                       
|              | 
|3.3           |  | Certificate of Amendment to Amended and Restated Certificate of Incorporation of ImmunoCellular Therapeutics, Ltd. (3)                                                                                                                                                                       
|              | 
|3.4           |  | Amended and Restated Bylaws of ImmunoCellular Therapeutics, Ltd. (4)                                                                                                                                                                                                                         
|              | 
|3.5           |  | Amended and Restated Bylaws of ImmunoCellular Therapeutics, Ltd. (25)                                                                                                                                                                                                                        
|              | 
|3.6           |  | Amended and Restated 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (25)                                                                                                                                                                                                    
|              | 
|4.1           |  | Form of Common Stock Certificate for ImmunoCellular Therapeutics, Ltd. (5)                                                                                                                                                                                                                   
|              | 
|4.2           |  | Form of Subscription Agreement containing registration rights issued by Spectral Molecular Imaging, Inc. in January 2006 and assumed by ImmunoCellular Therapeutics, Ltd.
(4)                                                                                                                
|              | 
|4.3           |  | Form of Warrant issued in January 2006 to purchase shares of the common stock of Spectral Molecular Imaging, Inc. and assumed by ImmunoCellular Therapeutics, Ltd.
(4)                                                                                                                       
|              | 
|4.4           |  | Subscription Agreement dated as of February 16, 2007 between ImmunoCellular Therapeutics, Ltd. and RAB Special Situations (Master) Fund Limited. (6)                                                                                                                                         
|              | 
|4.5           |  | Letter Agreement dated as of February 16, 2007 between ImmunoCellular Therapeutics, Ltd. and RAB Special Situations (Master) Fund Limited. (6)                                                                                                                                               
|              | 
|4.6           |  | Subscription Agreement dated as of April 19, 2007 between ImmunoCellular Therapeutics, Ltd. and RAB Special Situations (Master) Fund Limited. (6)                                                                                                                                            
|              | 
|4.7           |  | Warrant dated as of February 16, 2007 issued by ImmunoCellular Therapeutics, Ltd. to Credit Suisse Client Nominees (UK) Limited, as nominee for RAB Special Situations (Master) Fund
Limited, for the purchase of 800,000 shares of the common stock of ImmunoCellular Therapeutics, Ltd. (6)
|              | 
|4.8           |  | Warrant dated as of February 16, 2007 issued by ImmunoCellular Therapeutics, Ltd. to Credit Suisse Client Nominees (UK) Limited, as nominee for RAB Special Situations (Master) Fund
Limited, for the purchase of 533,334 shares of the common stock of ImmunoCellular Therapeutics, Ltd. (6)
|              | 
|4.9           |  | Warrant dated as of April 19, 2007 issued by ImmunoCellular Therapeutics, Ltd. to Credit Suisse Client Nominees (UK) Limited, as nominee for RAB Special Situations (Master)
Fund Limited, for the purchase of 200,000 shares of the common stock of ImmunoCellular Therapeutics, Ltd. (6)   



Ex - 1



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##### Table of Contents

|     |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|---- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|     | 
|4.10 |  | Warrant dated as of April 19, 2007 issued by ImmunoCellular Therapeutics, Ltd. to Credit Suisse Client Nominees (UK) Limited, as nominee for RAB Special Situations (Master)
Fund Limited, for the purchase of 133,334 shares of the common stock of ImmunoCellular Therapeutics, Ltd. (6)                                                                                                                                                                                   
|     | 
|4.11 |  | Form of Subscription Agreement containing registration rights between the participants in the April/May 2007 private placement and ImmunoCellular Therapeutics, Ltd.
(7)                                                                                                                                                                                                                                                                                                     
|     | 
|4.12 |  | Form of Warrant issued to participants in the April/May 2007 private placement to purchase shares of common stock of ImmunoCellular Therapeutics, Ltd. (7)                                                                                                                                                                                                                                                                                                                   
|     | 
|4.13 |  | Form of Notice of Exercise of Warrants delivered by ImmunoCellular Therapeutics, Ltd. in January 2009 in connection with the reduction from $2.50 to $0.25 per share of the exercise
price of warrants to purchase a total of 6,112,583 shares of common stock of ImmunoCellular Therapeutics, Ltd. and in connection with the extension of the expiration date of warrants to purchase a total of 6,412,583 shares of common stock of
ImmunoCellular Therapeutics, Ltd. (17)
|     | 
|4.14 |  | Certificate of Designations of Preferences, Rights and Limitations of Series A Preferred Stock dated December 3, 2009. (20)                                                                                                                                                                                                                                                                                                                                                  
|     | 
|4.15 |  | Warrant dated December 3, 2009 issued by ImmunoCellular Therapeutics, Ltd. to Socius Capital Group, LLC d/b/a Socius Life Sciences Capital Group, LLC (20)                                                                                                                                                                                                                                                                                                                   
|     | 
|4.16 |  | Amended Certificate of Designations of Preferences, Rights and Limitations of Series A Preferred Stock dated May 3, 2010. (22)                                                                                                                                                                                                                                                                                                                                               
|     | 
|4.17 |  | Form of Warrant issued to participants in the March 2010 private placement to purchase shares of common stock of ImmunoCellular Therapeutics, Ltd. (22)                                                                                                                                                                                                                                                                                                                      
|     | 
|4.18 |  | Warrant dated May 2, 2010 for 1,350,000 shares issued by ImmunoCellular Therapeutics, Ltd. to Socius CG II, Ltd. (22)                                                                                                                                                                                                                                                                                                                                                        
|     | 
|4.19 |  | Form of Warrant issued to participants in the February 2011 private placement to purchase shares of common stock of ImmunoCellular Therapeutics, Ltd. (26)                                                                                                                                                                                                                                                                                                                   
|     | 
|10.1 |  | Exclusive License Agreement dated as of November 17, 2006 between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd. (8)                                                                                                                                                                                                                                                                                                                                     
|     | 
|10.2 |  | First Amendment to Exclusive License Agreement dated as of June 16, 2008 2006, between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd. (9)                                                                                                                                                                                                                                                                                                                
|     | 
|10.3 |  | Stock Purchase Agreement dated as of November 17, 2006 between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd. (8)                                                                                                                                                                                                                                                                                                                                         
|     | 
|10.4 |  | Registration Rights Agreement dated as of November 17, 2006 between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd. (8)                                                                                                                                                                                                                                                                                                                                    
|     | 
|10.5 |  | Securities Purchase Agreement dated as of November 17, 2006 between Dr. John Yu and ImmunoCellular Therapeutics, Ltd. (8)                                                                                                                                                                                                                                                                                                                                                    
|     | 
|10.6 |  | Agreement dated as of November 17, 2006 between Dr. John Yu and ImmunoCellular Therapeutics, Ltd.* (8)                                                                                                                                                                                                                                                                                                                                                                       
|     | 
|10.7 |  | Nonqualified Stock Option Agreement dated as of November 17, 2006 between Dr. John Yu and ImmunoCellular Therapeutics, Ltd.* (8)                                                                                                                                                                                                                                                                                                                                             
|     | 
|10.8 |  | Registration Rights Agreement dated as of November 17, 2006 between Dr. John Yu and ImmunoCellular Therapeutics, Ltd. (8)                                                                                                                                                                                                                                                                                                                                                    
|     | 
|10.9 |  | 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (4)                                                                                                                                                                                                                                                                                                                                                                                                          



Ex - 2



---

##### Table of Contents

|      |  |                                                                                                                                                             
|----- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------
|      | 
|10.10 |  | Amendment No. 1 to the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (10)                                                                 
|      | 
|10.11 |  | Amendment No. 2 to the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (11)                                                                 
|      | 
|10.12 |  | Amendment No. 3 to the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (11)                                                                 
|      | 
|10.13 |  | Amendment No. 4 to the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (9)                                                                  
|      | 
|10.14 |  | Form of Non-Qualified Stock Option Agreement for the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (12)                                   
|      | 
|10.15 |  | Form of Incentive Stock Option Agreement for the 2006 Equity Incentive Plan of ImmunoCellular Therapeutics, Ltd. (12)                                       
|      | 
|10.16 |  | Employment Agreement dated as of February 18, 2008 between Dr. Manish Singh and ImmunoCellular Therapeutics, Ltd.* (11)                                     
|      | 
|10.17 |  | Employment Agreement dated as of February 18, 2009 between Dr. Manish Singh and ImmunoCellular Therapeutics, Ltd.* (17)                                     
|      | 
|10.18 |  | Employment Agreement dated as of November 5, 2007 between C. Kirk Peacock and ImmunoCellular Therapeutics, Ltd. (13)                                        
|      | 
|10.19 |  | Employment Agreement dated as of October 30, 2008 between C. Kirk Peacock and ImmunoCellular Therapeutics, Ltd.* (17)                                       
|      | 
|10.20 |  | Agreement dated as of July 7, 2006 between Technomedics Management & Systems, Inc. and ImmunoCellular Therapeutics, Ltd. (14)                               
|      | 
|10.21 |  | Agreement dated as of November 17, 2006 between Technomedics Management & Systems, Inc. and ImmunoCellular Therapeutics, Ltd.* (5)                          
|      | 
|10.22 |  | Memorandum of Agreement dated as of November 21, 2007 between Molecular Discoveries LLC and ImmunoCellular Therapeutics, Ltd. (11)                          
|      | 
|10.23 |  | Agreement dated as of February 14, 2008 between Molecular Discoveries, LLC and ImmunoCellular Therapeutics, Ltd. (11)                                       
|      | 
|10.24 |  | Registration Rights Agreement dated as of April 14, 2008, between Molecular Discoveries, LLC and ImmunoCellular Therapeutics, Ltd. (15)                     
|      | 
|10.25 |  | Agreement dated as of February 14, 2008 between Dr. Cohava Gelber and ImmunoCellular Therapeutics, Ltd. (11)*                                               
|      | 
|10.26 |  | Agreement dated as of August 1, 2008 between Dr. Cohava Gelber and ImmunoCellular Therapeutics, Ltd. * (17)                                                 
|      | 
|10.27 |  | Agreement dated as of September 1, 2008 between James G. Bender and ImmunoCellular Therapeutics, Ltd. (16) *                                                
|      | 
|10.28 |  | Office lease dated April 28, 2008 between Regent Business Centers and ImmunoCellular Therapeutics, Ltd., as amended. (17)                                   
|      | 
|10.29 |  | Amendment No. 1 to Agreement dated as of May 1, 2009 to Agreement dated October 30, 2008 between C. Kirk Peacock and ImmunoCellular Therapeutics, Ltd.
*(18)



Ex - 3



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##### Table of Contents

|      |  |                                                                                                                                                                                            
|----- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|      | 
|10.30 |  | Second Amendment dated August 1, 2009 to Exclusive License Agreement dated as of November 1, 2006 between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd.
(19)           
|      | 
|10.31 |  | Preferred Stock Purchase Agreement dated as of December 3, 2009 between ImmunoCellular Therapeutics, Ltd. and Socius Capital Group, LLC d/b/a Socius Life Sciences Capital
Group, LLC. (20)
|      | 
|10.32 |  | Employment Agreement dated as of October 30, 2009 between C. Kirk Peacock and ImmunoCellular Therapeutics, Ltd. *(21)                                                                      
|      | 
|10.33 |  | Employment Agreement dated as of February 1, 2010 between James G. Bender and ImmunoCellular Therapeutics, Ltd. * (27)                                                                     
|      | 
|10.34 |  | Employment Agreement dated as of February 18, 2010 between Dr. Manish Singh and ImmunoCellular Therapeutics, Ltd. * (27)                                                                   
|      | 
|10.35 |  | Agreement dated March 1, 2010 between Dr. John Yu and ImmunoCellular Therapeutics, Ltd. * (27)                                                                                             
|      | 
|10.36 |  | Securities Purchase Agreement dated March 29, 2010 between participants in the March 2010 private placement and ImmunoCellular Therapeutics, Ltd. (23)                                     
|      | 
|10.37 |  | Form of Registration Rights Agreement dated as of March 29, 2010 between participants in the March 2010 private placement and ImmunoCellular Therapeutics, Ltd. (22)                       
|      | 
|10.38 |  | Agreement dated as of March 4, 2010 between Dr. Elma Hawkins and ImmunoCellular Therapeutics, Ltd.* (22)                                                                                   
|      | 
|10.39 |  | Office Lease dated April 1, 2010 between Regent Business Centers and ImmunoCellular Therapeutics, Ltd. (22)                                                                                
|      | 
|10.40 |  | Modification Agreement dated May 2, 2010 among Socius CG II, Ltd., Socius Life Sciences Capital Group, LLC and ImmunoCellular Therapeutics, Ltd. (22)                                      
|      | 
|10.41 |  | Third Amendment dated March 26, 2010 to Exclusive License Agreement dated as of November 1, 2006 between Cedars-Sinai Medical Center and ImmunoCellular Therapeutics, Ltd.
(22)            
|      | 
|10.42 |  | Securities Purchase Agreement dated May 12, 2010 between participants in the May 2010 private placement and ImmunoCellular Therapeutics, Ltd. (23)                                         
|      | 
|10.43 |  | Form of Registration Rights Agreement between participants in the May 2010 private placement and ImmunoCellular Therapeutics, Ltd. (23)                                                    
|      | 
|10.44 |  | Employment Agreement dated as of October 30, 2010 between C. Kirk Peacock and ImmunoCellular Therapeutics, Ltd.* (24)                                                                      
|      | 
|10.45 |  | Office Lease dated May 7, 2010 between Regent Business Centers and ImmunoCellular Therapeutics, Ltd. (23)                                                                                  
|      | 
|10.46 |  | Purchase Agreement, dated as of February 22, 2011, by and between the Company and each investor named therein. (26)                                                                        
|      | 
|10.47 |  | Registration Rights Agreement, dated as of February 22, 2011, by and among the Company and the investors named therein. (26)                                                               
|      | 
|10.48 |  | Exclusive Sublicense Agreement dated May 28, 2010 between Targepeutics, Inc. and ImmunoCellular Therapeutics, Ltd. 
**                                                                    



Ex - 4



---

##### Table of Contents

|      |  |                                                                                                                                                                            
|----- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|      | 
|10.49 |  | Sponsored Research and Vaccine Production Agreement dated January 1, 2011 between The Trustees of the University of Pennsylvania and ImmunoCellular Therapeutics, Ltd. 
**
|      | 
|10.50 |  | Placement agent agreement dated March 30, 2010 between Gilford Securities Incorporated and ImmunoCellular Therapeutics, Ltd. **                                            
|      | 
|10.51 |  | Placement agent agreement dated April 7, 2010 between Scarsdale Equities LLC and ImmunoCellular Therapeutics, Ltd. **                                                      
|      | 
|10.52 |  | Consulting Agreement dated October 1, 2010 between JFS Investments and ImmunoCellular Therapeutics, Ltd. **                                                                
|      | 
|10.53 |  | Advisory services agreement dated October 1, 2010 between Garden State Securities Inc. and ImmunoCellular Therapeutics, Ltd. **                                            
|      | 
|10.54 |  | Co-placement Agents Agreement dated January 31, 2011 among Summer Street Research Partners, Dawson James Securities, Inc. and ImmunoCellular Therapeutics, Ltd. **         
|      | 
|23.1  |  | Consent of Marcum LLP. **                                                                                                                                                  
|      | 
|23.2  |  | Consent of Stonefield Josephson, Inc. **                                                                                                                                   
|      | 
|31.1  |  | Certification of the registrants Principal Executive Officer under Exchange Act Rule 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of
2002.**   
|      | 
|31.2  |  | Certification of the registrants Principal Financial Officer under Exchange Act Rule 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of
2002.**   
|      | 
|32.1  |  | Certification of the registrants Principal Executive Officer under 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
2002.**        
|      | 
|32.2  |  | Certification of the registrants Principal Financial Officer under 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of
2002.**        



| | Certain portions of the exhibit have been omitted based upon a request for confidential treatment filed by us with the Securities and Exchange Commission. The omitted
portions of the exhibit have been separately filed by us with the Securities and Exchange Commission.
|- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|* | Indicates a management contract or compensatory plan or arrangement.
|- | --------------------------------------------------------------------

|** | Filed with this Annual Report on Form 10-K.
|-- | -------------------------------------------

|(1) | Previously filed by us on January 26, 2006 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|--- | --------------------------------------------------------------------------------------------------------------------------------

|(2) | Previously filed by us on November 3, 2006 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|--- | --------------------------------------------------------------------------------------------------------------------------------

|(3) | Previously filed by us on May 9, 2007 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|--- | ---------------------------------------------------------------------------------------------------------------------------

|(4) | Previously filed by us on February 6, 2006 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|--- | --------------------------------------------------------------------------------------------------------------------------------

|(5) | Previously filed by us on February 12, 2007 as an exhibit to our Registration Statement on Form SB-2, File No. 333-140598, and incorporated herein by
reference.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Previously filed by us on May 1, 2007 as an exhibit to our Registration Statement on Form SB-2, File No. 333-142480, and incorporated herein by reference.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------

|(7) | Previously filed by us on July 12, 2007 as an exhibit to our Registration Statement on Form SB-2, File No. 333-144521, and incorporated herein by reference
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------

|(8) | Previously filed by us on November 22, 2006 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|--- | ---------------------------------------------------------------------------------------------------------------------------------



Ex - 5



---

##### Table of Contents

|(9) | Previously filed by us on August 14, 2008 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|--- | ----------------------------------------------------------------------------------------------------------------------------------

|(10) | Previously filed by us on September 14, 2007 as an exhibit to our Registration Statement on Form SB-2/A and incorporated herein by reference.
|---- | ---------------------------------------------------------------------------------------------------------------------------------------------

|(11) | Previously filed by us on March 25, 2008 as an exhibit to our Annual Report on Form 10-KSB and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------------------

|(12) | Previously filed by us on November 9, 2007 as an exhibit to our Registration Statement on Form S-8, File No. 333-147278, and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------------------------------------------------

|(13) | Previously filed by us on November 6, 2007 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------------------

|(14) | Previously filed by us on April 2, 2007 as an exhibit to our Annual Report on Form 10-KSB and incorporated herein by reference.
|---- | -------------------------------------------------------------------------------------------------------------------------------

|(15) | Previously filed by us on April 16, 2008 as an exhibit to our Registration Statement on Form S-1, File No. 333-150277, and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------

|(16) | Previously filed by us on November 13, 2008 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------------

|(17) | Previously filed by us on March 30, 2009 as an exhibit to our Annual Report on Form 10-K and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------

|(18) | Previously filed by us on August 14, 2009 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|---- | ----------------------------------------------------------------------------------------------------------------------------------

|(19) | Previously filed by us on November 13, 2009 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------------

|(20) | Previously filed by us on December 7, 2009 as an exhibit to our Current Report on Form 8-K and incorporated herein by reference.
|---- | --------------------------------------------------------------------------------------------------------------------------------

|(21) | Previously filed by us on December 23, 2009 as an exhibit to our Registration Statement on Form S-1 and incorporated herein by reference.
|---- | -----------------------------------------------------------------------------------------------------------------------------------------

|(22) | Previously filed by us on May 12, 2010 as an exhibit to our Registration Statement on Form S-1 to SB-2, File No. 333-144521 and incorporated herein by
reference.
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------

|(23) | Previously filed by us on May 18, 2010 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|---- | -------------------------------------------------------------------------------------------------------------------------------

|(24) | Previously filed by us on November 15, 2010 as an exhibit to our Quarterly Report on Form 10-Q and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------------

|(25) | Previously filed by us on January 11, 2011 as an exhibit to our Registration Statement on Form S-8 and incorporated herein by reference.
|---- | ----------------------------------------------------------------------------------------------------------------------------------------

|(26) | Previously filed by us on February 25, 2011 as an exhibit to our current report on Form 8-K and incorporated herein by reference.
|---- | ---------------------------------------------------------------------------------------------------------------------------------

|(27) | Previously filed by us on March 31, 2010 as an exhibit to our Annual Report on Form 10-K and incorporated herein by reference.
|---- | ------------------------------------------------------------------------------------------------------------------------------



Ex - 6