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                    U.S. DEPARTMENT OF AGRICULTURE
 Virus and Prion Research: Ames, IA
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ARS Home Midwest Area Ames, Iowa National Animal Disease Center Virus and Prion Research People & Locations







Justin  Greenlee
                        Virus and Prion Research

                        




                        
                        Research Veterinary Medical Officer
                        Phone: (515) 337-7191
                        
                        
                        Fax: (515) 337-7149(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            ProjectsElucidating the Pathobiology and Transmission of Transmissible Spongiform Encephalopathies
                                                    In-House Appropriated
                                                                    (D)Accession Number: 440677Assessing the Potential Transmissibility of Bovine and Cervid Prions with a Human Prion Protein-based Model
                                                    Non-Assistance Cooperative Agreement
                                                                    (S)Accession Number: 442757Investigation of a PRNP Polymorphism on Susceptibility to Bovine Spongiform Encephalopathy (BSE)
                                                    Non-Assistance Cooperative Agreement
                                                                    (S)Accession Number: 437152Development of a Transgenic Mouse that Expresses the Bovine Prion Polymorphism T231
                                                    Non-Assistance Cooperative Agreement
                                                                    (S)Accession Number: 437176**Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)Differentiation of scrapie from chronic wasting disease in white-tailed deer

- (Peer Reviewed Journal)Temporal serum neurofilament light chain concentrations in sheep inoculated with the agent of classical scrapie
                                                        

- (Peer Reviewed Journal)Lathrop, Q.L., Nicholson, E.M., Wang, C., Greenlee, J.J., Seger, H., Veneziano, S.E., Cassmann, E.D. 2024. Temporal serum neurofilament light chain concentrations in sheep inoculated with the agent of classical scrapie. PLOS ONE. https://doi.org/10.1371/journal.pone.0299038.Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases
                                                        

- (Peer Reviewed Journal)Zhang, W., Orru, C.D., Foutz, A., Ding, M., Yuan, J., Shah, S., Zhang, J., Kotobelli, K., Gerasimenko, M., Gilliland, T., Chen, W., Tang, M., Cohen, M., Safar, J., Xu, B., Hong, D., Ciu, L., Hughson, A.G., Schonberger, L.B., Tatsuoka, C., Chen, S.G., Greenlee, J.J., Wang, Z., Appleby, B.S., Caughey, B., Zou, W. 2024. Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases. Acta Neuropathologica. https://doi.org/10.1007/s00401-023-02661-2.Disease phenotype of classical sheep scrapie is changed upon experimental passage through white-tailed deer
                                                        

- (Peer Reviewed Journal)Kokemuller, R., Moore, S., Bian, J., West Greenlee, H.M., Greenlee, J.J. 2023. Disease phenotype of classical sheep scrapie is changed upon experimental passage through white-tailed deer. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1011815.Update: CWD genetic resistance project at NADC

- (Trade Journal)Cassmann, E.D., Greenlee, J.J. 2023. Update: CWD genetic resistance project at NADC. North American Deer Farmer. P. 83.Short incubation periods of atypical H-BSE to cattle with EK211 and KK211 prion protein genotypes after intracranial inoculation
                                                        

- (Peer Reviewed Journal)Cassmann, E.D., Freese, L.J., Becky, K.A., Greenlee, J.J. 2023. Short incubation periods of atypical H-BSE to cattle with EK211 and KK211 prion protein genotypes after intracranial inoculation. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2023.1301998.Is there a risk of transmission of the CWD agent to non-cervid species

- (Trade Journal)A comparison of CWD and scrapie in white-tailed deer and sheep

- (Abstract Only)Greenlee, J.J., Lambert, Z.J., Bian, J., West Greenlee, H.M. 2023. A comparison of CWD and scrapie in white-tailed deer and sheep (abstract). Chronic Wasting Disease Symposium Proceedings. 4th International Chronic Wasting Disease Symposium, May 30-June 3, 2023, Denver, Colorado.The chronic wasting disease agent from white-tailed deer is highly infectious to humanized mice after passage through raccoons

- (Abstract Only)Cassmann, E.D., Qi, X., Kong, Q., Greenlee, J.J. 2023. The chronic wasting disease agent from white-tailed deer is highly infectious to humanized mice after passage through raccoons (abstract). Meeting Abstract. 4th International Chronic Wasting Disease Symposium, May 30-June 3, 2023, Denver, Colorado.The chronic wasting disease agent from white-tailed deer fails to adapt to sheep upon second passage

- (Abstract Only)Frese, A.J., Cassmann, E.D., West Greenlee, H.M., Greenlee, J.J. 2023. The chronic wasting disease agent from white-tailed deer fails to adapt to sheep upon second passage (abstract). Meeting Abstract. 4th International Chronic Wasting Disease Symposium, May 30-June 3, 2023, Denver, Colorado.Preliminary results for neurofilament light chain as a serum biomarker for chronic wasting disease in white-tailed deer

- (Abstract Only)Cassmann, E.D., Quazetta, B., Lambert, Z., Frese, L., Greenlee, J.J. 2023. Preliminary results for neurofilament light chain as a serum biomarker for chronic wasting disease in white-tailed deer (abstract). Chronic Wasting Disease Symposium Proceedings. 4th International Chronic Wasting Disease Symposium, May 30-June 3, 2023, Denver, Colorado.Scrapie as the potential origin of chronic wasting disease in white-tailed deer

- (Abstract Only)Lambert, Z.J., West Greenlee, H.M., Bian, J., Cassmann, E.D., Greenlee, J.J. 2023. Scrapie as the potential origin of chronic wasting disease in white-tailed deer (abstract). Chronic Wasting Disease Symposium Proceedings. 4th International Chronic Wasting Disease Symposium, May 30-June 3, 2023, Denver, Colorado.A mass spectrometry-based method of quantifying the contribution of the lysine polymorphism at position 171 in sheep PrP
                                                        

- (Peer Reviewed Journal)Silva, C.J., Cassmann, E.D., Greenlee, J.J., Erickson-Beltran, M.L., Requena, J.R. 2023. A mass spectrometry-based method of quantifying the contribution of the lysine polymorphism at position 171 in sheep PrP. Journal of American Society for Mass Spectrometry. 34(2):245-254. https://doi.org/10.1021/jasms.2c00277.Characterization of classical sheep scrapie in white-tailed deer after experimental oronasal exposure
                                                        

- (Peer Reviewed Journal)Greenlee, J.J., Moore, S.J., Cassmann, E.D., Lambert, Z.J., Kokemuller, R., Smith, J.D., Kunkle, R.A., Kong, Q., West Greenlee, H.M. 2022. Characterization of classical sheep scrapie in white-tailed deer after experimental oronasal exposure. Journal of Infectious Diseases. 227(12):1386-1395. Article jiac443. https://doi.org/10.1093/infdis/jiac443.Effect of inoculation with prion dilutions within the dynamic range of ELISA absorbance on prion incubation period
                                                        

- (Peer Reviewed Journal)Cassmann, E.D., Brown, Q.L., Frese, A.J., Lambert, Z.J., West Greenlee, H.M., Greenlee, J.J. 2022. Effect of inoculation with prion dilutions within the dynamic range of ELISA absorbance on prion incubation period. Veterinary Research Communications. 46(4):1377-1380. https://doi.org/10.1007/s11259-022-10013-w.Combinatorial treatment of brain samples from sheep with scrapie using sodium percarbonate, sodium dodecyl sulfate, and proteinase K increases survival time in inoculated susceptible sheep
                                                        

- (Peer Reviewed Journal)Harm, T.A., Smith, J.D., Cassmann, E.D., Greenlee, J.J. 2022. Combinatorial treatment of brain samples from sheep with scrapie using sodium percarbonate, sodium dodecyl sulfate, and proteinase K increases survival time in inoculated susceptible sheep. Research in Veterinary Science. 152:497-503. https://doi.org/10.1016/j.rvsc.2022.09.002.Comparison of protein hallmarks of ferroptosis in mice with prion disease

- (Abstract Only)Mathias, C.E., Greenlee, H.W., Greenlee, J.J., Cassmann, E.D. 2022. Comparison of protein hallmarks of ferroptosis in mice with prion disease (abstract). Meeting Abstract. p.198.Transmission of raccoon passaged chronic wasting disease agent to white-tailed deer
                                                        

- (Peer Reviewed Journal)Cassmann, E.D., Frese, A.J., Moore, S.J., Greenlee, J.J. 2022. Transmission of raccoon passaged chronic wasting disease agent to white-tailed deer. Viruses. 14(7). Article 1578. https://doi.org/10.3390/v14071578.Exploring the possibility of CWD transmission through artificial insemination of semen from CWD positive bucks

- (Trade Journal)Cassmann, E.D., Greenlee, J.J. 2022. Exploring the possibility of CWD transmission through artificial insemination of semen from CWD positive bucks. North American Deer Farmer. p. 107-109.Cattle with the EK211 PRNP polymorphism are susceptible to the H-type bovine spongiform encephalopathy agent from either E211K or wild type donors after oronasal inoculation
                                                        

- (Abstract Only)Greenlee, J.J., Cassmann, E.D., Moore, S., West Greenlee, H.M. 2022. Cattle with the EK211 PRNP polymorphism are susceptible to the H-type bovine spongiform encephalopathy agent from either E211K or wild type donors after oronasal inoculation. Prion 2022 Conference abstracts: pushing the boundaries. 16(1):150. https://doi.org/10.1080/19336896.2022.2091286.The chronic wasting disease agent from white-tailed deer is highly infectious to humanized mice after passage through raccoons
                                                        

- (Abstract Only)Cassmann, E.D., Qi, X., Kong, Q., Greenlee, J.J. 2022. The chronic wasting disease agent from white-tailed deer is highly infectious to humanized mice after passage through raccoons. Prion 2022 Conference abstracts: pushing the boundaries. 16(1):120. https://doi.org/10.1080/19336896.2022.2091286.The chronic wasting disease agent from white-tailed deer fails to adapt to sheep upon second passage
                                                        

- (Abstract Only)Frese, A.J., Cassmann, E.D., West Greenlee, H.M., Greenlee, J.J. 2022. The chronic wasting disease agent from white-tailed deer fails to adapt to sheep upon second passage. Prion 2022 Conference abstracts: pushing the boundaries. 16(1):144. https://doi.org/10.1080/19336896.2022.2091286.Application of PMCA to understand CWD prion strains, species barrier and zoonotic potential
                                                        

- (Abstract Only)Pritzkow, S., Gorski, D., Ramirez, F., Wang, F., Telling, G.C., Greenlee, J.J., Benestad, S.L., Soto, C. 2022. Application of PMCA to understand CWD prion strains, species barrier and zoonotic potential. Prion 2022 Conference abstracts: pushing the boundaries. 16(1):209. https://doi.org/10.1080/19336896.2022.2091286.ATYPRION project: assessing the zoonotic potential of interspecies transmission of CWD isolates to livestock (preliminary results)
                                                        

- (Abstract Only)Vidal, E., Espinosa, J., Giler, S., Ordonez, M., Cantero, G., Beringue, V., Greenlee, J.J., Torres, J. 2022. ATYPRION project: assessing the zoonotic potential of interspecies transmission of CWD isolates to livestock (preliminary results). Prion 2022 Conference abstracts: pushing the boundaries. 16(1):240. https://doi.org/10.1080/19336896.2022.2091286.Generation of human chronic wasting disease in transgenic mice
                                                        

- (Abstract Only)Wang, Z., Qin, K., Camacho, M.V., Cali, I., Yuan, J., Shen, P., Gilliland, T., Shah, S., Gerasimenko, M., Tang, M., Rajamanickam, S., Yadati, A., Schonberger, L.B., Greenlee, J.J., Kong, Q., Mastrianni, J.A., Zou, W. 2022. Generation of human chronic wasting disease in transgenic mice. Prion 2022 Conference abstracts: pushing the boundaries. 16(1):243. https://doi.org/10.1080/19336896.2022.2091286.Second passage of scrapie in white-tailed deer is discernable from chronic wasting disease
                                                        

- (Abstract Only)Lambert, Z., West Greenlee, H.M., Cassmann, E.D., Greenlee, J.J. 2022. Second passage of scrapie in white-tailed deer is discernable from chronic wasting disease. Prion 2022 Conference abstracts: pushing the boundaries. 16(1):181. https://doi.org/10.1080/19336896.2022.2091286.Generation of human chronic wasting disease in transgenic mice

- (Proceedings)Wang, Z., Qin, K., Camacho, M.V., Cali, I., Yuan, J., Shen, P., Greenlee, J.J., Kong, Q., Mastrianni, J.A., Zou, W. 2022. Generation of human chronic wasting disease in transgenic mice. Proceedings of 10th Iberian Congress on Prions, May 19-20, 2022, Vila Real, Portugal.Chronic wasting disease isolates from Norway and North America lack evidence of common strain characteristics

- (Trade Journal)Cassmann, E.D., Greenlee, J.J. 2022. Chronic wasting disease isolates from Norway and North America lack evidence of common strain characteristics. North American Deer Farmer. p. 112.Increased attack rates and decreased incubation periods in raccoons with chronic wasting disease passaged through meadow voles
                                                        

- (Peer Reviewed Journal)Moore, S., Carlson, C., Schneider, J., Johnson, C., Greenlee, J.J. 2022. Increased attack rates and decreased incubation periods in raccoons with chronic wasting disease passaged through meadow voles. Emerging Infectious Diseases. 28(4). Article 210271. https://doi.org/10.3201/eid2804.210271.Differential accumulation of misfolded prion strains in natural hosts of prion diseases
                                                        

- (Review Article)Lambert, Z., Greenlee, J.J., Cassmann, E.D., West Greenlee, H.M. 2021. Differential accumulation of misfolded prion strains in natural hosts of prion diseases. Viruses. 13(12). Article 2453. https://doi.org/10.3390/v13122453.Why are specific tissue samples required for detection of chronic wasting disease prions

- (Trade Journal)Harm, T., Cassmann, E.D., Greenlee, J.J. 2021. Why are specific tissue samples required for detection of chronic wasting disease prions. North American Deer Farmer. p. 40-43.Attempted transmission of the CWD agent to deer with potentially resistant prion protein genotypes

- (Trade Journal)Greenlee, J.J., Cassmann, E.D. 2022. Attempted transmission of the CWD agent to deer with potentially resistant prion protein genotypes. North American Deer Farmer. p. 117.Generation of human chronic wasting disease in transgenic mice
                                                        

- (Peer Reviewed Journal)Wang, Z., Qin, K., Camacho, M., Ignazio, C., Yuan, J., Shen, P., Greenlee, J.J., Kong, Q., Mastrianni, J., Zou, W. 2021. Generation of human chronic wasting disease in transgenic mice. Acta Neuropathologica. 9. Article 158. https://doi.org/10.1186/s40478-021-01262-y.Experimental oronasal transmission of chronic wasting disease agent from white-tailed deer to Suffolk sheep
                                                        

- (Peer Reviewed Journal)Cassmann, E.D., Moore, S., Greenlee, J.J. 2021. Experimental oronasal transmission of chronic wasting disease agent from white-tailed deer to Suffolk sheep. Emerging Infectious Diseases. 27(12). https://doi.org/10.3201/eid2712.204978.Decrease in skin prion-seeding activity of prion-infected mice treated with a compound against human and animal prions: a first possible biomarker for prion therapeutics
                                                        

- (Peer Reviewed Journal)Ding, M., Teruya, K., Zhang, W., Lee, H., Yuan, J., Oguma, A., Camacho, M., Mitchell, M., Greenlee, J.J., Zou, W., Kong, Q., Doh-Ura, K., Cui, L. 2021. Decrease in skin prion-seeding activity of prion-infected mice treated with a compound against human and animal prions: a first possible biomarker for prion therapeutics. Molecular Neurobiology. https://doi.org/10.1007/s12035-021-02418-6.RT-QuIC detection of PrPsc in fecal samples from CWD infected White-tailed Deer using Bank Vole Substrate
                                                        

- (Peer Reviewed Journal)Hwang, S., Greenlee, J.J., Nicholson, E.M. 2021. RT-QuIC detection of PrPsc in fecal samples from CWD infected White-tailed Deer using Bank Vole Substrate. Frontiers in Veterinary Science. 8. Article 643754. https://doi.org/10.3389/fvets.2021.643754.Transmission of the atypical/nor98 scrapie agent to suffolk sheep with VRQ/ARQ, ARQ/ARQ, and ARQ/ARR genotypes
                                                        

- (Peer Reviewed Journal)Cassmann, E.D., Mammadova, J., Benestad, S., Moore, S., Greenlee, J.J. 2021. Transmission of the atypical/nor98 scrapie agent to suffolk sheep with VRQ/ARQ, ARQ/ARQ, and ARQ/ARR genotypes. PLoS ONE. 16(2). Article e0246503. https://doi.org/10.1371/journal.pone.0246503.Second passage of chronic wasting disease of mule deer in sheep compared to classical scrapie after intracranial inoculation
                                                        

- (Peer Reviewed Journal)Cassmann, E.D., Frese, R., Greenlee, J.J. 2021. Second passage of chronic wasting disease of mule deer in sheep compared to classical scrapie after intracranial inoculation. Journal of Veterinary Diagnostic Investigation. 33(4):711-720. https://doi.org/10.1177/10406387211017615.Autoclave treatment of the classical scrapie agent US No. 13-7 and experimental inoculation to susceptible VRQ/ARQ sheep via the oral route results in decreased transmission efficiency
                                                        

- (Peer Reviewed Journal)Cassmann, E.D., Mammadova, N., Greenlee, J.J. 2020. Autoclave treatment of the classical scrapie agent US No. 13-7 and experimental inoculation to susceptible VRQ/ARQ sheep via the oral route results in decreased transmission efficiency. PLoS ONE. 15(12). Article e0243009. https://doi.org/10.1371/journal.pone.0243009.Successful transmission of the chronic wasting disease (CWD) agent to white-tailed deer by intravenous blood transfusion
                                                        

- (Peer Reviewed Journal)Mammadova, N., Cassman, E., Greenlee, J.J. 2020. Successful transmission of the chronic wasting disease (CWD) agent to white-tailed deer by intravenous blood transfusion. Research in Veterinary Science. 133:304-306. https://doi.org/10.1016/j.rvsc.2020.10.009.Evaluation of antemortem diagnostic techniques in goats naturally infected with scrapie
                                                        

- (Peer Reviewed Journal)Mammadova, N., West Greenlee, H.M., Moore, J.S., Hwang, S., Lehmkuhl, A.D., Nicholson, E.M., Greenlee, J.J. 2020. Evaluation of antemortem diagnostic techniques in goats naturally infected with scrapie. Frontiers in Veterinary Science. 7. Article 517862. https://doi.org/10.3389/fvets.2020.517862.Bovine adapted transmissible mink encephalopathy is similar to L-BSE after passage through sheep with the VRQ/VRQ genotype but not VRQ/ARQ
                                                        

- (Peer Reviewed Journal)Cassmann, E.D., Moore, Sara, J, S.J., Kokemullar, R.D., Balkema-Buschman, A., Groschup, M., Nicholson, E.M., Greenlee, J.J. 2020. Bovine adapted transmissible mink encephalopathy is similar to L-BSE after passage through sheep with the VRQ/VRQ genotype but not VRQ/ARQ. BMC Veterinary Research. 16. Article 383. https://doi.org/10.1186/s12917-020-02611-0.CWD research update from NADC

- (Trade Journal)Cassmann, E.D., Greenlee, J.J. 2020. CWD research update from NADC. North American Deer Farmer. p.72-73.Experimental inoculation of CD11c+ B1 lymphocytes, CD68+ macrophages, or platelet-rich plasma from scrapie-infected sheep into susceptible sheep results in variable infectivity
                                                        

- (Peer Reviewed Journal)Mammadova, N., Cassmann, E., Moore, S., Nicholson, E.M., Greenlee, J.J. 2020. Experimental inoculation of CD11c+ B1 lymphocytes, CD68+ macrophages, or platelet-rich plasma from scrapie-infected sheep into susceptible sheep results in variable infectivity. Access Microbiology. 2(9). https://doi.org/10.1099/acmi.0.000155.Efficient transmission of US scrapie agent by intralingual route to genetically susceptible sheep with a low dose inoculum
                                                        

- (Peer Reviewed Journal)Mammadova, N., Cassmann, E., Greenlee, J.J. 2020. Efficient transmission of US scrapie agent by intralingual route to genetically susceptible sheep with a low dose inoculum. Research in Veterinary Science. 132:217-220. https://doi.org/10.1016/j.rvsc.2020.06.010.Ex-vivo brain slice culture model for chronic wasting disease
                                                        

- (Peer Reviewed Journal)Kondru, N., Manne, S., Kokemuller, R., Greenlee, J.J., West Greenlee, M.H., Nichols, T., Kong, Q., Anantharam, V., Kanthasamy, A., Halbur, P., Kanthasamy, A. 2020. Ex-vivo brain slice culture model for chronic wasting disease. Scientific Reports. 10:7640. https://doi.org/10.1038/s41598-020-64456-9.An ex vivo brain slice culture model of chronic wasting disease: implications for disease pathogenesis and therapeutic development
                                                        

- (Peer Reviewed Journal)Kondru, N., Manne, S., Kokemuller, R., Greenlee, J.J., West Greenlee, M.H., Nichols, T., Kong, Q., Anantharam, V., Kanthasamy, A., Halbur, P., Kanthasamy, A. 2020. An ex vivo brain slice culture model of chronic wasting disease: implications for disease pathogenesis and therapeutic development. Scientific Reports. 10. Article 7640. https://doi.org/10.1038/s41598-020-64456-9.Experimental study using multiple strains of prion disease in cattle reveals an inverse relationship between incubation time and misfolded prion accumulation, neuroinflammation, and autophagy
                                                        

- (Peer Reviewed Journal)Mammadova, N., West Greenlee, M.H., Moore, S.J., Sakaguchi, D.S., Greenlee, J.J. 2020. Experimental study using multiple strains of prion disease in cattle reveals an inverse relationship between incubation time and misfolded prion accumulation, neuroinflammation, and autophagy. American Journal of Pathology. 190(7):1461-1473. https://doi.org/10.1016/j.ajpath.2020.03.006.Experimental study using multiple strains of prion disease in cattle reveals an inverse relationship between incubation time and misfolded prion accumulation, neuroinflammation and autophagy
                                                        

- (Peer Reviewed Journal)Mammadova, N., West Greenlee, M.H., Moore, S.J., Sakaguchi, D.S., Greenlee, J.J. 2020. Experimental study using multiple strains of prion disease in cattle reveals an inverse relationship between incubation time and misfolded prion accumulation, neuroinflammation and autophagy. Scientific Reports. 190(7):1461-1473. https://doi.org/10.1016/j.ajpath.2020.03.006.Retina as a model to study in vivo transmission of alpha-synuclein in the A53T mouse model of Parkinson’s disease
                                                        

- (Book / Chapter)Mammadova, N., Baron, T., Verchere, J., Greenlee, J.J., West Greenlee, M.H. 2021. Retina as a model to study in vivo transmission of alpha-synuclein in the A53T mouse model of Parkinson’s disease. In: Singh S.R., Hoffman R.M., Singh A. (eds) Mouse Genetics. Methods in Molecular Biology. New York, NY: Humana. p.75-85. https://doi.org/10.1007/978-1-0716-1008-4_5.Novel strain of the chronic wasting disease agent isolated from experimentally inoculated elk with LL132 prion protein
                                                        

- (Peer Reviewed Journal)Moore, S.J., Tatum, T.L., Hwang, S., Vrentas, C.E., West Greenlee, M.H., Kong, Q., Nicholson, E.M., Greenlee, J.J. 2020. Novel strain of the chronic wasting disease agent isolated from experimentally inoculated elk with LL132 prion protein. Scientific Reports. 10(3148). https://doi.org/10.1038/s41598-020-59819-1.Novel strain of the chronic wasting disease agent isolated from experimentally inoculated elk with LL132 prion protein
                                                        

- (Peer Reviewed Journal)Moore, S., Tatum, T.L., Hwang, S., Vrentas, C.E., West Greenlee, M.H., Kong, Q., Nicholson, E.M., Greenlee, J.J. 2020. Novel strain of the chronic wasting disease agent isolated from experimentally inoculated elk with LL132 prion protein. Nature Scientific Reports. 10:1-13. Article 3148. https://doi.org/10.1038/s41598-020-59819-1.Pathogenesis, detection, and control of scrapie in sheep
                                                        

- (Review Article)Cassman, E.D., Greenlee, J.J. 2020. Pathogenesis, detection, and control of scrapie in sheep. American Journal of Veterinary Research. 81(7):600-614. https://doi.org/10.2460/ajvr.81.7.600.Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates
                                                        

- (Peer Reviewed Journal)Hwang, S., Greenlee, J.J., Nicholson, E.M. 2020. Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates. Scientific Reports. 15(1):e0227487. https://doi.org/10.1371/journal.pone.0227487.The pathogenesis, detection, and control of scrapie in sheep
                                                        

- (Review Article)Cassmann, E.D., Greenlee, J.J. 2020. The pathogenesis, detection, and control of scrapie in sheep. American Journal of Veterinary Research. 81(7):600-614. https://doi.org/10.2460/ajvr.81.7.600.Sheep are susceptible to the agent of TME by intracranial inoculation and have evidence of infectivity in lymphoid tissues
                                                        

- (Peer Reviewed Journal)Cassmann, E.D., Moore, S.J., Smith, J.D., Greenlee, J.J. 2019. Sheep are susceptible to the agent of TME by intracranial inoculation and have evidence of infectivity in lymphoid tissues. Frontiers in Veterinary Science. 6:430. https://doi.org/10.3389/fvets.2019.00430.Sheep are susceptible to the bovine adapted transmissible mink
encephalopathy agent by intracranial inoculation and have evidence of
infectivity in lymphoid tissues
                                                        

- (Peer Reviewed Journal)Cassmann, E.D., Moore, S.J., Smith, J.D., Greenlee, J.J. 2019. Sheep are susceptible to the bovine adapted transmissible mink encephalopathy agent by intracranial inoculation and have evidence of infectivity in lymphoid tissues. Frontiers in Veterinary Science. 6. https://doi.org/10.3389/fvets.2019.00430.The chronic wasting disease agent from mule deer has widespread lymphoid distribution in sheep after second passage intracranial inoculation

- (Abstract Only)Cassmann, E., Frese, R.D., Greenlee, J.J. 2019. The chronic wasting disease agent from mule deer has widespread lymphoid distribution in sheep after second passage intracranial inoculation. 2019 American College of Veterinary Pathologists Annual Meeting. Paper No. EY-56.In-situ temporospatial characterization of the glial response to prion infection
                                                        

- (Peer Reviewed Journal)Michael, A.V., Greenlee, J.J., Harm, T.A., Moore, S.J., Zhang, M., Lind, M.S., West Greenlee, M.H., Smith, J.D. 2019. In-situ temporospatial characterization of the glial response to prion infection. Veterinary Pathology. 57(1):90-107. https://doi.org/10.1177/0300985819861708.Scrapie in white-tailed deer: a strain of the CWD agent that efficiently transmits to sheep?
                                                        

- (Abstract Only)Greenlee, J.J., Kokemuller, R.D., Moore, S.J., West Greenlee, M.H. 2019. Scrapie in white-tailed deer: a strain of the CWD agent that efficiently transmits to sheep? Prion. 13. Article 223. https://doi.org/10.1080/19336896.2019.1615197.The agent of transmissible mink encephalopathy passaged in sheep is similar to BSE-L
                                                        

- (Abstract Only)Cassmann, E.D., Greenlee, J.J., Balkema-Buschmann, A., Groschup, M.H., Moore, S.J., Kokemuller, R. 2019. The agent of transmissible mink encephalopathy passaged in sheep is similar to BSE-L. Prion. 13. Article 49. https://doi.org/10.1080/19336896.2019.1615197.Incubation periods of classical and atypical bovine spongiform encephalopathies (BSE) reflect an inverse relationship between PrPSc-associated neuroinflammation and autophagy
                                                        

- (Abstract Only)Mammadova, N., West Greenlee, M.H., Moore, S.J., Sakaguchi, D.S., Greenlee, J.J. 2019. Incubation periods of classical and atypical bovine spongiform encephalopathies (BSE) reflect an inverse relationship between PrPSc-associated neuroinflammation and autophagy. Prion. 13. Article 242. https://doi.org/10.1080/19336896.2019.1615197.The diagnosis of the prion diseases of animals

- (Abstract Only)Greenlee, J.J. 2019. The diagnosis of the prion diseases of animals [abstract].2019 Tri-State plus One Histology Symposium. 05/08/2019.Raccoons accumulate PrPSc after intracranial inoculation with the agents of chronic wasting disease (CWD) or transmissible mink encephalopathy (TME) but not atypical scrapie
                                                        

- (Peer Reviewed Journal)Moore, S.J., Smith, J.D., Richt, J., Greenlee, J.J. 2019. Raccoons accumulate PrPSc after intracranial inoculation with the agents of chronic wasting disease (CWD) or transmissible mink encephalopathy (TME) but not atypical scrapie. Journal of Veterinary Diagnostic Investigation. 31(2):200-209. https://doi.org/10.1177/1040638718825290.Scrapie agent from different genotypes of sheep show different seeding activity with elk recombinant prion proteins in RT-QuIC
                                                        

- (Peer Reviewed Journal)Hwang, S., Greenlee, J.J., Vance, N.M., Nicholson, E.M. 2018. Source genotype influence on cross species transmission of transmissible spongiform encephalopathies evaluated by RT-QuIC. PLoS One. 13(12):e0209106. https://doi.org/10.1371/journal.pone.0209106.Sheep with the homozygous lysine-171 prion protein genotype are resistant to classical scrapie after experimental oronasal inoculation
                                                        

- (Peer Reviewed Journal)Cassmann, E.D., Moore, S.J., Smith, J.D., Greenlee, J.J. 2018. Sheep with the homozygous lysine-171 prion protein genotype are resistant to classical scrapie after experimental oronasal inoculation. Veterinary Pathology. 56(3):409-417. https://doi.org/10.1177/0300985818817066.Accelerated accumulation of retinal alpha-synuclein (pSer129) and tau, neuroinflammation, and autophagic dysregulation in a seeded mouse model of Parkinson's disease
                                                        

- (Peer Reviewed Journal)Mammadova, N., Summers, C.M., Kokemuller, R.D., He, Q., Ding, S., Baron, T., Yu, C., Valentine, R.J., Sakaguchi, D.S., Kanthasamy, A.G., Greenlee, J.J., West Greenlee, M.H. 2019. Accelerated accumulation of retinal alpha-synuclein (pSer129) and tau, neuroinflammation, and autophagic dysregulation in a seeded mouse model of Parkinson's disease. Neurobiology of Disease. 121:1-16. https://doi.org/10.1016/j.nbd.2018.09.013.Sheep are susceptible to the agent of transmissible mink encephalopathy after intracranial inoculation

- (Abstract Only)Distribution of atypical porcine pestivirus in the cerebellum of newborn piglets following in utero inoculation

- (Abstract Only)Review: update on classical and atypical scrapie in sheep and goats
                                                        

- (Review Article)Greenlee, J.J. 2018. Review: update on classical and atypical scrapie in sheep and goats. Veterinary Pathology. 56(1):6-16. https://doi.org/10.1177/0300985818794247.The agent of H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism transmits after oronasal challenge

- (Abstract Only)Greenlee, J.J., Moore, S.J., West Greenlee, M.H. 2018. The agent of H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism transmits after oronasal challenge. Prion 2018, May 22-25, 2018, Santiago de Compostela, Spain. Paper No. P98, page 116.Retinopathy in a mouse model of Parkinson’s disease: seeding of synucleinopathy induces accumulation of phosphorylated alpha-synuclein (pSer129) and tau, neuroinflammation, metabolic dysregulation, and cell death

- (Abstract Only)Mammadova, N., Kokemuller, R., Summers, C.M., He, Q., Ding, S., Baron, T., Yu, C., Valentine, R.J., Sakaguchi, D.S., Kanthasamy, A.G., Greenlee, J.J., West Greenlee, M.H. 2018. Retinopathy in a mouse model of Parkinson's disease: seeding of synucleinopathy induces accumulation of phosphorylated alpha-synuclein (pSer129) and tau, neuroinflammation, metabolic dysregulation, and cell death. Prion 2018, May 22-25, 2018, Santiago de Compostela, Spain. Paper No. P144. p. 149-150.The agent of chronic wasting disease from pigs is infectious in transgenic mice expressing human PRNP

- (Abstract Only)Moore, S.J., Kokemuller, R.D., West-Greenlee, M.H., Balkema-Buschmann, A., Groschup, M.H., Greenlee, J.J. 2018. The agent of chronic wasting disease from pigs is infectious in transgenic mice expressing human PRNP. Prion 2018, Santiago de Compostela, Spain, May 22-25, 2018. Paper No. WA15, page 44.RT-QuIC seeding activity using elk recombinant prion proteins discriminates scrapie isolates

- (Abstract Only)Hwang, S., Greenlee, J.J., Vance, N.M., Nicholson, E.M. 2018. RT-QuIC seeding activity using elk recombinant prion proteins discriminates scrapie isolates. Prion 2018. Poster No. P58, p. 85.Pathologic and biochemical characterization of PrPSc from elk with PRNP polymorphisms at codon 132 after experimental infection with the chronic wasting disease agent
                                                        

- (Peer Reviewed Journal)Moore, S.J., Vrentas, C.E., Hwang, S., West Greenlee, M.H., Nicholson, E.M., Greenlee, J.J. 2018. Pathologic and biochemical characterization of PrPSc from elk with PRNP polymorphisms at codon 132 after experimental infection with the chronic wasting disease agent. BMC Veterinary Research. 14(1):80. https://doi.org/10.1186/s12917-018-1400-9.Detection of BSE prions by RT-QuIC in cattle with subclinical BSE
                                                        

- (Peer Reviewed Journal)Hwang, S., West Greenlee, M.H., Balkema-Buschmann, A., Groschup, M.H., Nicholson, E.M., Greenlee, J.J. 2018. Real-time quaking-induced conversion detection of bovine spongiform encephalopathy prions in a subclinical steer. Frontiers in Veterinary Science. 4:242. https://doi.org/10.3389/fvets.2017.00242.Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species

- (Peer Reviewed Journal)Vrentas, C.E., Greenlee, J.J., Foster, G.H., West, J., Jahnke, M.M., Schmidt, M.T., Nicholson, E.M. 2017. Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species. BMC Research Notes. 10:759. https://doi.org/10.1186/s13104-017-3085-8.Experimental transmission of the chronic wasting disease agent to swine after oral or intracranial inoculation

- (Peer Reviewed Journal)Moore, S.J., West Greenlee, M.H., Kondru, N., Manne, S., Smith, J.D., Kunkle, R.A., Kanthasamy, A., Greenlee, J.J. 2017. Experimental transmission of the chronic wasting disease agent to swine after oral or intracranial inoculation. Journal of Virology. 91(19):e00926-17. https://doi.org/10.1128/JVI.00926-17.Pathology in practice: pituitary adenoma in a sheep
                                                        

- (Peer Reviewed Journal)Smith, J.D., Harm, T.A., Greenlee, J.J. 2019. Pathology in practice: pituitary adenoma in a sheep. Journal of the American Veterinary Medical Association. 254(7):819-821. https://doi.org/10.2460/javma.254.7.819.Passage of scrapie to deer results in a new phenotype upon return passage to sheep

- (Abstract Only)Accumulation of phosphorylated alpha-synuclein (p129S) and retinal pathology in a mouse model of Parkinson's disease

- (Abstract Only)Disease-associated prion protein detected in lymphoid tissues from pigs challenged with the agent of chronic wasting disease

- (Abstract Only)Lasting retinal injury in a mouse model of blast-induced trauma

- (Peer Reviewed Journal)Mammadova, N., Ghaisas, S., Zenitsky, G., Sakaguchi, D.S., Kanthasamy, A.G., Greenlee, J.J., West Greenlee, M.H. 2017. Lasting retinal injury in a mouse model of blast-induced trauma. American Journal of Pathology. 187(7):1459-1472. doi:10.1016/j.ajpath.2017.03.005.Use of bovine recombinant prion protein and real-time quaking-induced conversion to detect transmissible mink encephalopathy prions and discriminate classical and atypical L- and H-type bovine spongiform encephalopathy

- (Peer Reviewed Journal)Hwang, S., Greenlee, J.J., Nicholson, E.M. 2017. Use of bovine recombinant prion protein and real-time quaking-induced conversion to detect cattle transmissible mink encephalopathy prions and discriminate classical and atypical L- and H-type bovine spongiform encephalopathy. PLoS One. 12(2):e0172391.Integrated organotypic slice cultures and RT-QuIC (OSCAR) assay: implications for translational discovery in protein misfolding diseases

- (Peer Reviewed Journal)Kondru, N., Manne, S., Greenlee, J., West Greenlee, H., Anantharam, V., Halbur, P., Kanthasamy, A., Kanthasamy, A. 2017. Integrated organotypic slice cultures and RT-QuIC (OSCAR) assay: implications for translational discovery in protein misfolding diseases. Scientific Reports. 7:43155. doi:10.1038/srep43155.Transmission of chronic wasting disease of white-tailed deer to Suffolk sheep following intracranial inoculation

- (Abstract Only)Temporospatial distribution of microglial activation in a murine model of scrapie

- (Abstract Only)Survival time and stability properties of disease-associated prion protein in chronic wasting disease of elk

- (Abstract Only)Scrapie in swine: a diagnostic challenge

- (Peer Reviewed Journal)Greenlee, J.J., Kunkle, R.A., Smith, J.D., West Greenlee, M.H. 2016. Scrapie in swine: a diagnostic challenge. Food Safety. 4(4):110-114.A comparison of classical and H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism in wild type and EK211 cattle following intracranial inoculation

- (Peer Reviewed Journal)Moore, S.J., West Greenlee, M.H., Smith, J.D., Vrentas, C.E., Nicholson, E.M., Greenlee, J.J. 2016. A comparison of classical and H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism in wild type and EK211 cattle following intracranial inoculation. Frontiers in Veterinary Science. 3:78.Horizontal transmission of chronic wasting disease in reindeer

- (Peer Reviewed Journal)Moore, S., Kunkle, R., Greenlee, M., Nicholson, E., Richt, J., Hamir, A., Waters, W., Greenlee, J. 2016. Horizontal transmission of chronic wasting disease in reindeer. Emerging Infectious Diseases. 22(12):2142-2145. doi:10.3201/eid2212.160635.Genetic variation of the prion protein gene (PRNP) in alpaca (Vicugna pacos)

- (Peer Reviewed Journal)Vermette, M.S., Schleining, J.A., Greenlee, J.J., Smith, J.D. 2016. Genetic variation of the prion protein gene (PRNP) in alpaca (Vicugna pacos). Gene Reports. 4:213–217.Temporal resolution of misfolded prion protein transport, accumulation, glial activation, and neuronal death in the retinas of mice inoculated with scrapie

- (Peer Reviewed Journal)West Greenlee, M.H., Lind, M., Kokemuller, R., Mammadova, N., Kondru, N., Manne, S., Smith, J., Kanthasamy, A., Greenlee, J. 2016. Temporal resolution of misfolded prion protein transport, accumulation, glial activation, and neuronal death in the retinas of mice inoculated with scrapie. American Journal of Pathology. 186(9):2302–2309.Scrapie in swine: a diagnostic challenge

- (Abstract Only)Prion infectivity detected in swine challenged with chronic wasting disease via the intracerebral or oral route

- (Abstract Only)Temporal resolution of PrPSc transport, PrPSc accumulation, activation of glia and neuronal death in retinas from C57Bl/6 mice inoculated with RML scrapie: Relevance to biomarkers of prion disease progression

- (Abstract Only)Limited amplification of chronic wasting disease prions in the peripheral tissues of intracerebrally inoculated cattle

- (Peer Reviewed Journal)Haley, N.J., Siepker, C., Greenlee, J.J., Richt, J.A. 2016. Limited amplification of chronic wasting disease prions in the peripheral tissues of intracerebrally inoculated cattle. Journal of General Virology. 97:1720-1724.Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrPSc accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype

- (Peer Reviewed Journal)Greenlee, J.J., Smith, J.D., Hamir, A.N. 2016. Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrPSc accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype. Research in Veterinary Science. 105:188–191.Comparison of two US sheep scrapie isolates supports identification as separate strains

- (Peer Reviewed Journal)Moore, S.J., Smith, J.D., West Greenlee, M.H., Nicholson, E.M., Richt, J.A., Greenlee, J.J. 2016. Comparison of two US sheep scrapie isolates supports identification as separate strains. Veterinary Pathology. 53(6):1187-1196. doi: 10.1177/0300985816629712.Antemortem detection of chronic wasting disease prions in nasal brush collections and rectal biopsies from white-tailed deer by real time quaking-induced conversion

- (Peer Reviewed Journal)Haley, N.J., Siepker, C., Walter, W.D., Thomsen, B.V., Greenlee, J.J., Lehmkuhl, A.D., Richt, J.A. 2016. Antemortem detection of chronic wasting disease prions in nasal brush collections and rectal biopsy specimens from white-tailed deer by real time quaking-induced conversion. Journal of Clinical Microbiology. 54(4):1108-1116.Scrapie transmits to white-tailed deer by the oral route and has a molecular profile similar to chronic wasting disease

- (Abstract Only)Transmission of chronic wasting disease to sentinel reindeer (Rangifer tarandus tarandus)

- (Abstract Only)Transmission of scrapie prions to primate after an extended silent incubation period

- (Peer Reviewed Journal)Comoy, E.E., Mikol, J., Luccantoni-Freire, S., Correia, E., Lescoutra-Etchegaray, N., Durand, V., Dehen, C., Andreoletti, O., Casalone, C., Richt, J.A., Greenlee, J.J., Baron, T., Benestad, S., Brown, P., Deslys, J. 2015. Transmission of scrapie prions to primate after an extended silent incubation period. Scientific Reports. 5:11573.Transmission of the agent of sheep scrapie to deer results in PrPSc with two distinct molecular profiles

- (Abstract Only)Greenlee, J., Moore, S.J., Smith, J.., West Greenlee, M.H., Kunkle, R. 2015. Scrapie transmits to white-tailed deer by the oral route and has a molecular profile similar to chronic wasting disease and distinct from the scrapie inoculum. Prion 2015. p. S62.Development and characterization of an ex-vivo brain slice culture model of chronic wasting disease

- (Abstract Only)Kondru, N., Greenlee, J., Greenlee, H., Manne, S., Kong, Q., Halbur, P., Kanthasamy, A., Kanthasamy, A. 2015. Development and characterization of an ex-vivo brain slice culture model of chronic wasting disease. Prion 2015. p. S68.Relationship of PrPSc molecular properties with incubation time in a natural prion disease host: a characterization of three isolates of U.S. sheep scrapie

- (Abstract Only)Vrentas, C., Smith, J., Greenlee, J., Nicholson, E. 2015. Relationship of PrPSc molecular properties with incubation time in a natural prion disease host: a characterization of 3 isolates of US sheep scrapie. Prion 2015. p. S92.H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism: clinical and pathologic features in wild-type and E211K cattle following intracranial inoculation

- (Abstract Only)Moore, S.J., West Greenlee, M.H., Smith, J., Nicholson, E., Vrentas, C., Greenlee, J. 2015. H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism: clinical and pathologic features in wild-type and E211K cattle following intracranial inoculation. Prion 2015. p. S5.Prion peripheralization is a host-driven trait of prion infection, independent of strain

- (Abstract Only)Clinical stage of infection is critical in the antemortem diagnosis of chronic wasting disease in deer and elk

- (Abstract Only)The transmissible spongiform encephalopathies of livestock

- (Review Article)Greenlee, J.J., West Greenlee, M.,H. 2015. The transmissible spongiform encephalopathies of livestock. ILAR Journal. 56(1):7-25.Raman spectroscopy reveals spectroscopic changes in histologically normal retinas in a mouse model of alpha-synucleinopathy

- (Abstract Only)hTERT-immortalized ovine microglia propagate natural scrapie isolates

- (Peer Reviewed Journal)Munoz-Gutierrez, J.F., Schneider, D.A., Baszler, T.V., Dinkel, K.D., Greenlee, J.J., Nicholson, E.M., Stanton, J.J. 2015. hTERT-immortalized ovine microglia propagate natural scrapie isolates. Virus Research. 198:35-43.Lack of prion accumulation in lymphoid tissues of PRNP ARQ/ARR sheep intracranially inoculated with the agent of scrapie

- (Peer Reviewed Journal)Greenlee, J.J., Kunkle, R.A., Richt, J.A., Nicholson, E.M., Hamir, A.N. 2014. Lack of prion accumulation in lymphoid tissues of PRNP ARQ/ARR sheep intracranially inoculated with the agent of scrapie. PLoS One. 9(9):e108029.Bovine Spongiform Encephalopathy: Atypical Pros and Cons

- (Proceedings)Kehrli Jr, M.E., Greenlee, J.J., Nicholson, E.M. 2014. Bovine Spongiform Encephalopathy: Atypical Pros and Cons. Proceedings of the California Animal Nutrition Conference, May 13-16, 2014, Fresno, California. p. 70-81.The prion diseases of animals

- (Book / Chapter)Greenlee J.J. 2014. The prion diseases of animals. In: McManus, L.M., Mitchell, R.N., editors. Pathobiology of Human Disease. San Diego: Elsevier. p. 1124-1133.Time-course study of retinal pathology in C57BL/6 mice infected with RML scrapie

- (Abstract Only)Lind, M., Smith, J.D., Briggie, L., West Greenlee, M., Greenlee, J.J. 2013. Time-course study of retinal pathology in C57BL/6 mice infected with RML scrapie. American College of Veterinary Pathologists Meeting. Available: http://www.acvp.org/index.php/en/2014-11-07-21-58-13/2013-annual-meeting.Stability properties of PrPSc from cattle with experimental transmissible spongiform encephalopathies

- (Peer Reviewed Journal)Vrentas, C.E., Greenlee, J.J., Baron, T., Caramelli, M., Czub, S., Nicholson, E.M. 2013. Stability properties of PrPSc from cattle with experimental transmissible spongiform encephalopathies: use of a rapid whole homogenate, protease-free assay. BMC Veterinary Research. 9:167.Evaluation of the zoonotic potential of transmissible mink encephalopathy

- (Peer Reviewed Journal)Comoy, E.E., Mikol, J., Ruchoux, M., Durand, V., Luccantoni-Freire, S., Dehen, C., Correia, E., Casalone, C., Richt, J.A., Greenlee, J.J., Torres, J.M., Brown, P., Deslys, J. 2013. Evaluation of the zoonotic potential of transmissible mink encephalopathy. Pathogens. 2:(3)520-532.Characterization of the first case of naturally occurring chronic wasting disease in a captive red deer (Cervus elaphus) in North America

- (Abstract Only)Lehmkuhl, A.L., Thomsen, B.V., Greenlee, J.J., Balachandran, A., O'Rourke, K., Hall, S. 2013. Characterization of the first case of naturally occurring chronic wasting disease in a captive red deer (Cervus elaphus) in North America. Prion 2013. AD-12-Prion (2013).7:22.Atypical BSE: role of the E211K prion polymorphism

- (Abstract Only)Greenlee, J.J. 2013. Atypical BSE: role of the E211K prion polymorphism. 2013 American Veterinary Medical Association (AVMA) Annual Convention, July 19-23, 2013, Chicago, Illinois. Paper No. 13920. p. 45.A low molecular-weight ferroxidase is increased in the CSF of sCJD cases: CSF ferroxidase and transferrin as diagnostic biomarkers for sCJD

- (Peer Reviewed Journal)Haldar, S., Beveridge, A.J., Wong, J., Singh, A.J., Galimberti, D., Borroni, D., Zhu, X., Blevins, J., Greenlee, J., Perry, G., Mukhopadhyay, C.K., Schmotzer, C., Singh, N. 2014. A low-molecular-weight ferroxidase is increased in the CSF of sCJD Cases: CSF ferroxidase and transferrin as diagnostic biomarkers for sCJD. Antioxidants & Redox Signaling. 19(14):1662-1675.Detection of PrP(Sc) in peripheral tissues of clinically affected cattle after oral challenge with bovine spongiform encephalopathy

- (Peer Reviewed Journal)Franz, M., Eiden, M., Balkema-Buschmann, A., Greenlee, J., Schatzl, H., Fast, C., Richt, J., Hildebrandt, J.P., Groschup, M.H. 2012. Detection of PrP(Sc) in peripheral tissues of clinically affected cattle after oral challenge with bovine spongiform encephalopathy. Journal of General Virology. 93(Pt12):2740-2748.Relationships between PrPSc stability and incubation time for United States scrapie strains in a natural host system

- (Peer Reviewed Journal)Vrentas, C.E., Greenlee, J.J., Tatum, T.L., Nicholson, E.M. 2012. Relationships between PrPSc stability and incubation time for United States scrapie isolates in a natural host system. PLoS ONE. 7(8):e43060.Comparative aspects of bovine spongiform encephalopathy isolates found in the U.S.

- (Abstract Only)Greenlee, J.J., Smith, J.D., Vrentas, C.E., West Greenlee, M.H., Nicholson, E.M. 2012. Comparative aspects of bovine spongiform encephalopathy isolates found in the U.S. American College of Veterinary Pathologists 63rd Annual Meeting. Paper No. E-16.Susceptibility of cattle to the agent of chronic wasting disease from elk after intracranial inoculation

- (Peer Reviewed Journal)Greenlee, J.J., Nicholson, E.M., Smith, J.D., Kunkle, R.A., Hamir, A.N. 2012. Susceptibility of cattle to the agent of chronic wasting disease from elk after intracranial inoculation. Journal of Veterinary Diagnostic Investigation. 24(6):1087-1093.Use of an ELISA-based stability assay to examine host genotype, PrP**Sc stability, and incubation time relationships in U.S. livestock prion strains

- (Abstract Only)Vrentas, C.E., Nicholson, E.M., Greenlee, J.J. 2012. Use of an ELISA stability assay to examine host genotype, PrPSc stability, and incubation time relationships in U.S. livestock prion strains. 26th Annual Symposium of The Protein Society. p. 211.Stability of PrP**Sc from cattle inoculated with different BSE strains

- (Abstract Only)Nicholson, E.M., Vrentas, C.E., Greenlee, J.J. 2012. Stability of PrPSc from cattle inoculated with different BSE strains. 26th Annual Symposium of The Protein Society. p. 210.Prolonged incubation time in sheep with prion protein containing lysine at position 171

- (Peer Reviewed Journal)Greenlee, J.J., Zhang, Xia, Nicholson, E.M., Kunkle, R.A., Hamir, A.N. 2012. Prolonged incubation time in sheep with prion protein containing lysine at position 171. Journal of Veterinary Diagnostic Investigation. 24(3):554-558.Experimental Interspecies Transmission Studies of the Transmissible Spongiform Encephalopathies to Cattle: Comparison to Bovine Spongiform Encephalopathy in Cattle

- (Review Article)Hamir, A.N., Kehrli, Jr., M.E., Kunkle, R.A., Greenlee, J.J., Nicholson, E.M., Richt, J.A., Miller, J.M., Cutlip, R.C. 2011. Experimental interspecies transmission studies of the transmissible spongiform encephalopathies to cattle: comparison to bovine spongiform encephalopathy in cattle. Journal of Veterinary Diagnostic Investigation. 23(3):407-420.PrPSc detection in formalin-fixed paraffin-embedded tissue by ELISA

- (Peer Reviewed Journal)Nicholson, E.M., Greenlee, J.J., Hamir, A.N. 2011. PrPSc detection in formalin-fixed paraffin-embedded tissue by ELISA. BMC Research Notes. 4(1):432.Evaluation of two sets of immunohistochemical and Western blot confirmatory methods in the detection of typical and atypical BSE cases

- (Peer Reviewed Journal)Porcario, C., Hall, S.M., Martucci, F., Corona, C., Iulini, B., Perazzini, A.Z., Acutis, P., Hamir, A.N., Loiacono, C.M., Greenlee, J.J., Richt, J.A., Caramelli, M., Casalone, C. 2011. Evaluation of two sets of immunohistochemical and Western blot confirmatory methods in the detection of typical and atypical BSE cases. BMC Research Notes. 4:376.Salivary prions in sheep and deer

- (Peer Reviewed Journal)Tamguney, G., Richt, J.A., Hamir, A.N., Greenlee, J.J., Miller, M.W., Wolfe, L.L., Sirochman, T.M., Young, A.J., Glidden, D.V., Johnson, N.L., Giles, K., Dearmond, S.J., Prusiner, S.B. 2012. Salivary prions in sheep and deer. Prion. 6(1):52-61.Comparison of Transmissible Mink Encephalopathy Isolates in Raccoons

- (Abstract Only)Smith, J.D., Greenlee, J.J., Hamir, A.N. 2010. Comparison of transmissible mink encephalopathy isolates in raccoons [abstract]. American College of Veterinary Pathologists. Paper No. 145.White-Tailed Deer Susceptible to Scrapie by Natural Route of Infection

- (Abstract Only)Greenlee, J.J., Smith, J.D., Kunkle, R.A. 2010. White-tailed deer susceptible to scrapie by natural route of infection [abstract]. American College of Veterinary Pathologists. Paper No. 81.G-CSF Analogue Treatment Increases Peripheral Neutrophil Numbers in Pigs - a Potential Alternative for In-Feed Antibiotics

- (Abstract Only)Loving, C.L., Brockmeier, S.L., Bayles, D.O., Greenlee, J.J., Lager, K.M., Kehrli, Jr., M.E. 2010. G-CSF analogue treatment increases peripheral neutrophil numbers in pigs - a potential alternative for in-feed antibiotics. Conference of Research Workers in Animal Diseases. Paper No. 140.Bronchial carcinoma in a Red Shouldered Hawk (Buteo lineatus)

- (Peer Reviewed Journal)Greenlee, J.J., Nieves, M.A., Myers, R.K. 2011. Bronchial carcinoma in a red-shouldered hawk (Buteo lineatus). Journal of Zoo and Wildlife Medicine. 42(1):153-155.White-Tailed Deer Susceptible to Scrapie by Natural Route of Infection

- (Abstract Only)Identification of an Amino Acid Domain Encoded by the Capsid Protein Gene of Porcine Circovirus Type 2 that Modulates Viral Protein Distribution During Replication

- (Peer Reviewed Journal)Cheung, A.K., Greenlee, J.J. 2011. Identification of an amino acid domain encoded by the capsid gene of porcine circovirus type 2 that modulates intracellular viral protein distribution during replication. Virus Research. 155(1):358-362.Clinical features in prion protein-deficient and wild-type cattle inoculated with transmissible mink encephalopathy (TME)

- (Abstract Only)Vargas, F., Kuroiwa, Y., Hamir, A.N., Greenlee, J.J., Kunkle, R.A., Kangas, T., Kanthasamy, A., Robl, J., Richt, J. A. 2010. Clinical features in prion protein-deficient and wild-type cattle inoculated with transmissible mink encephalopathy (TME) [abstract]. XXVI World Buiatrics Congress 2010, November 14-18, 2010, Santiago, Chile. Available: http://www.kenes.com/buiatrics/cd/pdf/780.pdf.White-tailed Deer are Susceptible to Sheep Scrapie by Intracerebral Inoculation

- (Abstract Only)Greenlee, J.J., Smith, J.D., Kunkle, R.A. 2010. White-tailed deer are susceptible to sheep scrapie by intracerebral inoculation [abstract]. Prion 4(3):144.Experimental Transmission of Chronic Wasting Disease (CWD) from Elk (Cervus elaphus nelsoni) and White-tailed Deer (Odocoileus virginianus) to Fallow Deer (Dama dama) by Intracerebral Route: Final Report

- (Peer Reviewed Journal)Hamir, A.N., Greenlee, J.J., Nicholson, E.M., Kunkle, R.A., Richt, J.A., Miller, J.M., Hall, M. 2011. Experimental transmission of chronic wasting disease (CWD) from elk and white-tailed deer to fallow deer by intracerebral route: final report. Canadian Journal of Veterinary Research. 75(2):152-156.Experimental Inoculation of Spiroplasma mirum and Transmissible Mink Encephalopathy (TME) into Raccoons (Procyon lotor)

- (Peer Reviewed Journal)Hamir, A.N., Greenlee, J.J., Stanton, T.B., Smith, J.D., Doucette, S., Kunkle, R.A., Stasko, J.A., Richt, J.A., Kehrli, Jr., M.E. 2011. Experimental inoculation of raccoons (Procyon lotor) with Spiroplasma mirum and transmissible mink encephalopathy (TME). Canadian Journal of Veterinary Research. 75(1):18–24.Detection of the Abnormal Isoform of the Prion Protein Associated With Chronic Wasting Disease in the Optic Pathways of the Brain and Retina of Rocky Mountain Elk (Cervus elaphus nelsoni)

- (Peer Reviewed Journal)Spraker, T.R., Orourke, K.I., Gidlewski, T.L., Powers, J., Greenlee, J.J., Wild, M.A. 2010. Detection of the Abnormal Isoform of the Prion Protein Associated With Chronic Wasting Disease in the Optic Pathways of the Brain and Retina of Rocky Mountain Elk (Cervus elaphus nelsoni). Veterinary Pathology. 47(3):536-546.New potentials in TSE diagnostics

- (Abstract Only)Greenlee, J.J., Smith, J.D., Greenlee, M.S. 2009. New potentials in TSE diagnostics [abstract]. International Veterinary Vaccines and Diagnostics Conference. p. 42.Lack of Prion Accumulation in Lymphoid Tissues of Scrapie-affected Sheep with the AA136, QR171 Prion Protein Genotype

- (Abstract Only)Kunkle, R.A., Hamir, A.N., Richt, J., Greenlee, J.J., Nicholson, E.M., Kehrli, Jr., M.E. 2009. Lack of Prion Accumulation in Lymphoid Tissues of Scrapie-affected Sheep with the AA136, QR171 Prion Protein Genotype [abstract]. American Association of Veterinary Laboratory Diagnosticians. Paper No. 186.Susceptibility of Cattle to First-Passage Intracerebral Inoculation with Chronic Wasting Disease Agent from Elk

- (Abstract Only)Greenlee, J.J., Nicholson, E.M., Kunkle, R.A., Hamir, A.N. Susceptibility of Cattle to First-Passage Intracerebral Inoculation with Chronic Wasting Disease Agent from Elk [abstract]. American College of Veterinary Pathologists Annual Meeting. Veterinary Pathology. 46(5):1058.Guanidinium Chloride Unfolding of PrP**Sc Exhibits Marked Differences Between Genotypes

- (Abstract Only)Nicholson, E.M., Greenlee, J.J., Kunkle, R.A., Hamir, A.N. 2009. Guanidinium Chloride Unfolding of PrP**Sc Exhibits Marked Differences Between Genotypes [abstract]. Prion 2009. p. 182.Prolonged Incubation Time in Sheep with QK171 Genotype

- (Abstract Only)Greenlee, J.J., Nicholson, E.M., Kunkle, R.A., Hamir, A.N. 2009. Prolonged Incubation Time in Sheep with QK171 Genotype [abstract]. Prion 2009. p. 120.Characterization of a U.S. Sheep Scrapie Isolate with Short Incubation Time

- (Peer Reviewed Journal)Hamir, A.N., Richt, J.A., Kunkle, R.A., Greenlee, J.J., Bulgin, M.S., Gregori, L., Rohwer, R.G. 2009. Characterization of a U.S. Sheep Scrapie Isolate with Short Incubation Time. Veterinary Pathology. 46(6):1205-1212.Origins of BSE: evidence of sporadic and heritable BSE

- (Abstract Only)Nicholson, E.M., Brunelle, B.W., Kehrli, Jr., M.E., Greenlee, J.J. 2008. Origins of BSE: Evidence of Sporadic and Heritable BSE [abstract]. United States-Japan Cooperative Program in Natural Resources. p. 7.Experimental transmission of U.S. scrapie agent to neonatal sheep by oral route

- (Peer Reviewed Journal)Hamir, A.N., Kunkle, R.A., Greenlee, J.J., Richt, J.A. 2009. Experimental Oral Transmission of United States Origin Scrapie to Neonatal Sheep. Journal of Veterinary Diagnostic Investigation. 21(1):64-68.Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus, Bos indicus, and composite cattle

- (Peer Reviewed Journal)Brunelle, B.W., Greenlee, J.J., Seabury, C.M., Brown II, C.E., Nicholson, E.M. 2008. Frequencies of Polymorphisms Associated with BSE Resistance Differ Significantly Between Bos taurus, Bos indicus, and Composite Cattle. BioMed Central (BMC) Veterinary Research. 4(1):36. Available: http://www.biomedcentral.com/1746-6148/4/36.Serial passage of sheep scrapie inoculum in Suffolk sheep

- (Peer Reviewed Journal)Hamir, A.N., Kunkle, R.A., Richt, J.A., Greenlee, J.J., Miller, J.M. 2009. Serial Passage of Sheep Scrapie Inoculum in Suffolk Sheep. Veterinary Pathology. 46(1):39-44.Experimental transmission of transmissible spongiform encephalopathies (scrapie, chronic wasting disease, transmissible mink encephalopathy) to cattle and their differentiation from bovine spongiform encephalopathy

- (Abstract Only)Hamir, A.N., Cutlip, R.C., Miler, J.M., Kunkle, R.A., Richt, J.A., Greenlee, J.J., Nicholson, E.M., Kehrli, Jr., M.E. 2008. Experimental Transmission of Transmissible Spongiform Encephalopathies (Scrapie, Chronic Wasting Disease, Transmissible Mink Encephalopathy) to Cattle and Their Differentiation from Bovine Spongiform Encephalopathy [abstract]. American College of Veterinary Pathologists. Paper No. 153. p. 770.Strain typing of U.S. scrapie strains using a panel of inbred mice

- (Abstract Only)Greenlee, J.J., Kunkle, R.A., Nicholson, E.M., Hamir, A.N., Bulgin, M.S., Richt, J. 2009. Strain Typing of U.S. Scrapie Strains Using a Panel of Inbred Mice [abstract]. American College of Veterinary Pathologists. Paper No. 121. p. 762.Identification of a heritable polymorphism in bovine PRNP associated with genetic transmissible spongiform encephalopathy: evidence of heritable BSE

- (Peer Reviewed Journal)Nicholson, E.M., Brunelle, B.W., Richt, J.A., Kehrli, Jr., M.E., Greenlee, J.J. 2008. Identification of a Heritable Polymorphism in Bovine PRNP Associated with Genetic Transmissible Spongiform Encephalopathy: Evidence of Heritable BSE. PloS ONE. 3(8):e2912.Identification of a heritable polymorphism in the bovine prion gene associated with genetic transmissible spongiform encephalopathy: evidence of heritable BSE

- (Abstract Only)Nicholson, E.M., Brunelle, B.W., Richt, J.A., Kehrli, Jr., M.E., Greenlee, J.J. 2008. Identification of a Heritable Polymorphism in the Bovine Prion Gene Associated with Genetic Transmissible Spongiform Encephalopathy: Evidence of Heritable BSE [abstract]. Prion 2008. p. 114.Experimental transmission of transmissible spongiform encephalopathies (scrapie, chronic wasting disease, transmissible mink encephalopathy) to cattle and their differentiation from bovine spongiform encephalopathy

- (Abstract Only)Hamir, A.N., Kunkle, R.A., Richt, J.A., Greenlee, J.J., Nicholson, E.M., Kehrli, Jr., M.E. 2008. Experimental Transmission of Transmissible Spongiform Encephalopathies (Scrapie, Chronic Wasting Disease, Transmissible Mink Encephalopathy) to Cattle and their Differentiation from Bovine Spongiform Encephalopathy [abstract]. Prion 2008. p. 65.Lack of prion accumulation in lymphoid tissues of scrapie-affected sheep with AA136, QR171 polymorphism type

- (Abstract Only)Kunkle, R.A., Hamir, A.N., Richt, J.A., Greenlee, J.J., Nicholson, E.M., Kehrli, Jr., M.E. 2008. Lack of Prion Accumulation in Lymphoid Tissues of Scrapie-Affected Sheep with AA136, QR171 Polymorphism Type [abtract]. Prion 2008. p. 75.Western-blot detection of PrP**sc in archived paraffin-embedded brainstem from scrapie-affected sheep

- (Peer Reviewed Journal)Kunkle, R.A., Nicholson, E.M., Lebepe-Mazur, S., Orcutt, D.L., Srinivas, M.L., Greenlee, J.J., Alt, D.P., Hamir, A.N. 2008. Western blot detection of PrP**sc in archived paraffin-embedded brainstem from scrapie-affected sheep. Journal of Veterinary Diagnostic Investigation. 20(4):522-526.Experimental transmission of chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni), white-tailed deer (Odocoileus virginianus), and mule deer (Odocoileus hemionus hemionus) to white-tailed deer by intracerebral route

- (Peer Reviewed Journal)Hamir, A.N., Richt, J., Miller, J.M., Kunkle, R.A., Hall, S., Nicholson, E.M., Orourke, K.I., Greenlee, J.J., Williams, E.S. 2008. Experimental transmission of chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni), white-tailed deer (Odocoileus virginianus), and mule deer (Odocoileus hemionus hemionus) to white-tailed deer by intracerebral route. Veterinary Pathology. 45(3):297-306.Prolonged CWD incubation time and unique PrP**d profile in Prnp 132LL elk

- (Abstract Only)Greenlee, J.J., O'Rourke, K.I., Hamir, A.N., Gidlewski, T., Zhuang, D., Spraker, T. 2007. Prolonged CWD Incubation Time and Unique PrP**d Profile in Prnp 132LL Elk. In: Proceedings of the U.S. Animal Health Association 111th Annual Meeting, Captive Wildlife and Alternative Livestock Committee, October 20, 2007, Reno, Nevada. p. 264-265.Retinal cell types are differentially affected in sheep with scrapie

- (Peer Reviewed Journal)Smith, J.D., Greenlee, J.J., Hamir, A.N., West Greenlee, M.H. 2008. Retinal cell types are differentially affected in sheep with scrapie. Journal of Comparative Pathology. 138(1):12-22.Elk with a long incubation prion disease phenotype have a unique PrP-d profile

- (Peer Reviewed Journal)O'Rourke, K.I., Spraker, T.R., Zhuang, D., Greenlee, J.J., Gidlewski, T.E., Hamir, A.N. 2007. Elk with a long incubation prion disease phenotype have a unique PrP-d profile. NeuroReport. 18(18):1935-1938.Experimental transmission of U.S. scrapie agent by nasal, peritoneal and conjunctival routes to genetically susceptible sheep

- (Peer Reviewed Journal)Hamir, A.N., Kunkle, R.A., Richt, J.A., Miller, J.M., Greenlee, J.J. 2008. Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep. Veterinary Pathology. 45(1):7-11.Abnormal prion protein in the retina of Rocky Mountain elk (Cervus Elaphus Nelsoni)

- (Abstract Only)Spraker, T, Greenlee, J., Gidlewski T., O’Rourke, K. 2007. Abnormal Prion Protein in the Retina of Rocky Mountain Elk (Cervus Elaphus Nelsoni) [abstract]. Prion 2007. Paper No. P03.70. p. 64.Experimental transmission of transmissible spongiform encephalopathies (scrapie, chronic wasting disease, transmissible mink encephalopathy) to cattle and their differentiation from bovine spongiform encephalopathy

- (Proceedings)Hamir, A.N., Cutlip, R.C., Miller, J.M., Kunkle, R.A., Richt, J.A., Greenlee, J.J., Nicholson, E.M., Kehrli, Jr., M.E. 2007. Experimental transmission of transmissible spongiform encephalopathies (scrapie, chronic wasting disease, transmissible mink encephalopathy) to cattle and their differentiation from bovine spongiform encephalopathy. In: Proceedings of the World Association of Veterinary Laboratory Diagnosticians 13th International Symposium, November 11-14, 2007, Melbourne, Australia. p. 29.Detection of PrP**CWD in retinal tissues in white-tailed deer (Odocoileus virginianus) and Rocky Mountain elk (Cervus elaphus nelsoni) with CWD

- (Abstract Only)Spraker, T., Gidleweski, T., Greenlee, J., Keane, D., Hamir, A., Orourke, K. 2007. Detection of PrP**CWD in retinal tissues in white-tailed deer (Odocoileus virginianus) and Rocky Mountain elk (Cervus elaphus nelsoni) with CWD [abstract]. American Association of Veterinary Laboratory Diagnosticians 50th Annual Meeting. p. 47.Cross-species transmission of TSE

- (Proceedings)Richt, J.A., Hamir, A.N., Kunkle, R.A., Nicholson, E.M., Greenlee, J.J. 2007. Cross-species transmission of TSE. In: Proceedings of the American College of Veterinary Internal Medicine. 2007 ACVIM Forum, June 6-9, 2007, Seattle, Washington. Paper No. 160.EXPERIMENTAL TRANSMISSION OF CHRONIC WASTING DISEASE (CWD) OF ELK (CERVUS ELAPHUS NELSONI), WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS), AND MULE DEER (ODOCOILEUS HEMIONUS HEMIONUS) TO WHITE-TAILED DEER BY INTRACEREBRAL ROUTE

- (Abstract Only)Kunkle, R.A., Hamir, A.N., Miller, J.M., Hall, S.M., Richt, J.A., Greenlee, J.J., Williams, E.S. 2006. Experimental transmission of chronic wasting disease (CWD) of elk (Cervus Elaphus Nelsoni), white-tailed deer (Odocoileus Virginianus), and mule deer (Odocoileus Hemionus Hemionus) to white-tailed deer by intracerebral route [abstract]. United States Animal Health Association. p. 221.ATTEMPTED TRANSMISSION OF SCRAPIE AND CWD TO SWINE: PRELIMINARY FINDINGS

- (Proceedings)Greenlee, J.J., Kunkle, R.A. Nicholson, E.M., Lager, K.M., Hamir, A.N. 2006. Attempted transmission of scrapie and CWD to swine: preliminary findings. 19th International Pig Veterinary Society Congress. p. 386.ABNORMAL PRION ACCUMULATION ASSOCIATED WITH RETINAL PATHOLOGY IN EXPERIMENTALLY INOCULATED SCRAPIE-AFFECTED SHEEP

- (Peer Reviewed Journal)Greenlee, J.J., Hamir, A.N., West Greenlee, M.H. 2006. Abnormal prion accumulation associated with retinal pathology in experimentally inoculated scrapie-affected sheep. Veterinary Pathology. 43:733-739.EXPERIMENTAL TRANSMISSION OF TRANSMISSIBLE MINK ENCEPHALOPATHY (TME) TO CATTLE BY INTRACEREBRAL INOCULATION

- (Abstract Only)Hamir, A.N., Kunkle, R.A., Miller, J.M., Greenlee, J.J., Richt, J.A. 2006. Experimental transmission of transmissible mink encephalopathy (TME) to cattle by intracerebral inoculation [abstract]. 4th International Veterinary Vaccines and Diagnostics Conference. p. 89. Paper No. PO53.CROSS-SPECIES TSE TRANSMISSION STUDIES AT NADC

- (Abstract Only)Hamir, A.N., Cutlip, R.C., Miller, J.M., Kunkle, R.A., Greenlee, J.J., Richt, J.A. 2006. Cross-species TSE transmission studies at NADC [abstract]. 4th International Veterinary Vaccines and Diagnostics Conference. p. 89. Paper No. PO52.EXPERIMENTAL INTRACEREBRAL AND ORAL INOCULATION OF SCRAPIE TO SWINE: PRELIMINARY REPORT

- (Abstract Only)Greenlee, J.J., Kunkle, R.A., Hamir, A.N. 2005. Experimental intracerebral and oral inoculation of scrapie to swine: preliminary report [abstract]. Proceedings of the American Association of Veterinary Laboratory Diagnosticians 48th Annual Conference. p. 38.NATURAL AND EXPERIMENTAL PRION DISEASES OF CATTLE

- (Abstract Only)Richt, J.A., Hamir, A.N., Kunkle, R.A., Nicholson, E.M., Greenlee, J.J., Miller, J.M., Cutlip, R., Davis, A.J., Hall, S.M. 2005. Natural and experimental prion diseases of cattle [abstract]. Third International Rushmore Conference on Enteric Diseases. Paper No. 14.EXPERIMENTAL SECOND PASSAGE OF CHRONIC WASTING DISEASE (CWD(MULE DEER)) AGENT TO CATTLE

- (Peer Reviewed Journal)Hamir, A.N., Kunkle, R.A., Miller, J.M., Greenlee, J.J., Richt, J.A. 2006. Experimental second passage of chronic wasting disease (CWD(mule deer)) agent to cattle. Journal of Comparative Pathology. 134(1):63-69.EXPERIMENTAL TRANSMISSION OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES (TSE) AT THE NATIONAL ANIMAL DISEASE CENTER, AMES, IOWA: AN UPDATE

- (Abstract Only)Hamir, A.N., Cutlip, R.C., Miller, J.M., Kunkle, R.A., Greenlee, J.J., Richt, J.A. 2005. Experimental transmission of transmissible spongiform encephalopathies (TSE) at the National Animal Disease Center, Ames, Iowa: an update [abstract]. American Association of Veterinary Laboratory Diagnosticians. p. 169.BIOCHEMISTRY OF PRION DISEASES

- (Abstract Only)Nicholson, E.M., Greenlee, J.J., Richt, J., Hamir, A.N., Kunkle, R.A., Kehrli, Jr., M.E. 2005. Biochemistry of prion diseases. Association of Analytical Communities International, Midwest Section [abstract].  Abstract No. 601.  p. 38.EXPERIMENTAL TRANSMISSION OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES (TSES) AT THE NATIONAL ANIMAL DISEASE CENTER (NADC), AMES, IOWA, USA: AN UPDATE

- (Abstract Only)Hamir, A.N., Cutlip, R.C., Miller, J.M., Kunkle, R.A., Greenlee, J.J., Richt, J.A., Bartz, J. 2005. Experimental transmission of transmissible spongiform encephalopathies (TSEs) at the National Animal Disease Center (NADC), Ames, Iowa, USA: An update [abstract]. Annual Wildlife Disease Association Conference. p. 263.EXPERIMENTAL CANINE LEPTOSPIROSIS CAUSED BY LEPTOSPIRA INTERROGANS SEROVARS POMONA AND BRATISLAVA

- (Peer Reviewed Journal)Greenlee, J.J., Alt, D.P., Bolin, C.A., Zuerner, R.L., Andreasen, C.B. 2005. Experimental canine Leptospirosis caused by Leptospira interrogans serovars Pomona and Bratislava. American Journal of Veterinary Research. 66(10):1816-1822.LOSS OF PRION PROTEIN IMMUNOREACTIVITY AFTER BOILING IN SATURATED CALCIUM HYDROXIDE SOLUTION

- (Abstract Only)Greenlee, J.J., Nicholson, E.M., Hamir, A.N., Richt, J.A., Kunkle, R.A., Noyes, G., Hotzapple, M.T., Kehrli Jr., M.E. 2005. Loss of prion protein immunoreactivity after boiling in saturated calcium hydroxide solution [abstract]. Keystone Symposia: Molecular Mechanisms of Transmissible Spongiform Encephalopathies. Poster No. 125.


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