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ARS Home Pacific West Area Davis, California Western Human Nutrition Research Center Obesity and Metabolism Research People Lindsay Allen





Allen Labheadline bar **ALLEN LAB (MILQ LAB)** /ARSUserFiles/34942/Allen Lab 4.jpg    Research Scientist
                              **Lindsay Allen, Ph.D.**
Research Leader
Research Professor, UC Davis Department of Nutrition
Office: (530) 752-5268
Email address: lindsay.allen@usda.gov
Google Scholar page
**Research Interests**
The Allen laboratory focuses on: (1) metabolic and functional effects of vitamin B12 status and supplementation, including the development and validation of a new B12 status indicator (cB12) and metabolomics; (2) new methods for efficient micronutrient analyses in human milk; (3) development of Reference Values for nutrients in human milk; (4) assessment of the impact of maternal supplementation on milk quality and consequences for the exclusively breastfed infant.
**Allen Lab Themes**
The Mothers, Infants, and Lactation Quality Study (MILQ): Developing Reference Values for Nutrients in Human Milk (Bill & Melinda Gates Foundation):The purpose of the MILQ study is to provide Reference Values for micronutrients and other milk constituents based on the range of concentrations analyzed in the milk of well-nourished, un-supplemented women in four countries (Bangladesh, Brazil, Denmark, and The Gambia), from delivery through 8.49 months of lactation. The study will also measure many factors that could affect milk composition, including milk volume and maternal nutrient intake and status, and relationships to infant status and the intestinal microbiome.
Biomarkers of Vitamin B12 Status:We are using existing samples from intervention studies to assess the effect of B12 status and interventions on (1) a new combined marker of B12 status (cB12); (2) serum metabolites analyzed with metabolomics; (3) B12 concentrations in human milk.
Improving Public Health by Understanding Diversity in Diet, Body, and Brain Interactions (WHNRC 5-year mission project):The iMAPS Study focuses on (1) comparing metabolic, physiologic, and behavioral responses to consumption of a high quality vs. typical American diet pattern; (2) discovering interrelationships between metabolically important tissues that contribute to metabolic health and energy homeostasis; (3) identifying physiological and psychological processes that influence behavior related to food intake.
Assessing the Impact of Diet on Inflammation in Healthy and Obese Adults in a Cross-Sectional Phenotyping Study and a Longitudinal Intervention Trial (WHNRC 5-year mission project):The goals of the Phenotyping Study are to (1) determine how diet quality (assessed using the Healthy Eating Index), nutritional status (assessed using biomarkers in a cross-sectional study) and adherence to a diet following Dietary Guidelines recommendations for intake of fat and fat-soluble vitamins affect immune function and inflammation; (2) determine the degree of modulation and the mechanism of activation or inhibition of blood monocytes by different types of dietary fatty acids and by fruit-derived dietary polyphenols or their metabolites; (3) evaluate whether and how the challenge meal-induced monocyte activation is suppressed by docosahexaenoic acid; and (4) whether the diets affect challenge meal-induced monocyte activation.
Additional current collaborations:
• Maryanne Perrin (milk B12 in vegetarian and vegan mothers in the USA)
• Tor Strand (B-vitamins in milk from Norwegian and Nepalese women)
• Christopher Golden (Madagascar, Darwin Project)
• Lisa Houghton/Rosalind Gibson (vitamins in milk from Indonesian women)
• Guy-Marino Hinnouho/Sonja Hess (thiamin, B12, and folate status of children in Laos)
 Research Team
                              **ARS Employees**
Setareh Shahab-Ferdows, Nutritionist, Lab Manager
Dr. Shahab-Ferdows research interests include (a) one carbon metabolism; (b) effects of micronutrient supplementation and fortification; (c) maternal and child nutrition; and (d) breastfeeding practices and breast milk quality. She was involved in the development and validation of the first analysis of vitamin B12 in human milk without the need of time consuming pre-treatment. She serves as Coordinator for the Mothers, Infants and Lactation Quality (MILQ) project.
Daniela Hampel, Food Chemist, Project Scientist
Dr. Hampel research focuses on method development for and implementation of micronutrient analyses in human milk and plasma/serum as a tool to assess (a) micronutrient deficiencies in mostly developing countries; (b) adequate micronutrient intake for mothers, human milk status, and infants 0-6 months; (c) relationships between maternal, milk, and infant biomarkers and characteristics; and (d) how maternal treatment or supplementation affect such relationships. She has developed the first simultaneous analysis of several B-vitamins in human milk and established an extended portfolio of micronutrient analyses for the milk matrix in the Allen Lab.
Zeynep Alkan, Chemist (Support Scientist), Point of collaboration with Lemay Lab
 Selected Publications(Clicking on the reprint iconReprint Icon  will take you to the publication reprint.)Validation and application of Biocrates AbsoluteIDQ® p180 targeted metabolomics kit using human milk-(Peer Reviewed Journal) Hampel, D., Shahab-Ferdows, S., Hossain, M., Islam, M., Ahmed, T., Allen, L.H. 2019. Validation and application of Biocrates AbsoluteIDQ® p180 targeted metabolomics kit using human milk. Nutrients. 11(8):1733. https://doi.org/10.3390/nu11081733.Cohort description of the Madagascar health and environmental research-antongil (MAHERY-Antongil) study in Madagascar-(Peer Reviewed Journal) Golden, C.D., Borgerson, C., Rice, B.L., Allen, L.H., Anjaranirina, J.G., Barrett, C.B., Boateng, G., Gephart, J.A., Hampel, D., Hartl, D.L., Knippenberg, E., Myers, S.S., Ralalason, D.H., Ramihantaniarivo, H., Randriamady, H.J., Shahab-Ferdows, S., Vaitla, B., Volkman, S.K., Vonona, M.A. 2019. Cohort description of the Madagascar health and environmental research-antongil (MAHERY-Antongil) study in Madagascar. Frontiers in Nutrition. 6:109. https://doi.org/10.3389/fnut.2019.00109.Micronutrient intakes of lactating mothers and their association with breastmilk concentrations and micronutrient adequacy of exclusively breastfed Indonesian infants-(Peer Reviewed Journal)NIH workshop on human milk composition: summary and visions-(Peer Reviewed Journal) Casavale, K.O., Ahuja, J.K., Wu, X., Li, Y., Quam, J., Olson, R., Pehrsson, P.R., Allen, L.H., Balentine, D., Hanspal, M., Hayward, D., Hines, E.P., Mcclung, J., Perrine, C., Belfort, M.B., Dallas, D., German, D., Kim, J., Mcguire, M., Mcguire, M., Morrow, A., Nommsen-Rivers, Rasmussen, K.M., Zempleni, J., Lynch, C. 2019. NIH workshop on human milk composition: summary and visions. American Journal of Clinical Nutrition. 2016;44(D1):D463–470.. https://doi.org/10.1093/ajcn/nqz123.Endocannabinoid metabolome characterization of milk from Guatemalan women living in the Western Highlands-(Peer Reviewed Journal) Gaitan, A.V., Wood, J.T., Solomons, N.W., Donohue, J.A., Ji, L., Liu, Y., Nikas, S.P., Zhang, F., Allen, L.H., Makriyannis, A., Lammi-Keefe, C.J. 2019. Endocannabinoid metabolome characterization of milk from Guatemalan women living in the Western Highlands. Current Developments in Nutrition. 3(6):1-6. https://doi.org/10.1093/cdn/nzz018.Micronutrient intakes of lactating mothers and their association with breast milk concentrations and micronutrient adequacy of exclusively breastfed Indonesian infants-(Peer Reviewed Journal) Daniels, L., Gibson, R.S., Diana, A., Haszard, J.J., Rahmannia, S., Luftimas, D.E., Hambel, D., Shahab-Ferdows, S., Reid, M., Melo, L., Lamers, Y., Allen, L.H., Houghton, L.A. 2019. Micronutrient intakes of lactating mothers and their association with breast milk concentrations and micronutrient adequacy of exclusively breastfed Indonesian infants. American Journal of Clinical Nutrition. 110(2):391-400. https://doi.org/10.1093/ajcn/nqz047.Breast milk provides inadequate amounts of vitamin B12 for predominantly breastfed Guatemalan infants-(Peer Reviewed Journal) Anaya-Loyola, M.A., Brito, A., Brown, K.H., Allen, L.H. 2019. Breast milk provides inadequate amounts of vitamin B12 for predominantly breastfed Guatemalan infants. International Journal for Vitamin and Nutrition Research. p. 1664-2821. https://doi.org/10.1024/0300-9831/a000583.Prenatal iron deficiency and replete iron status are associated with adverse birth outcomes, but associations differ in Ghana and Malawi-(Peer Reviewed Journal) Oaks, B.M., Jorgensen, J.M., Baldiviez, L.M., Adu-Afarwuah, S., Maleta, K., Okronipa, H., Sadalaki, J., Lartey, A., Ashorn, P., Ashorn, U., Vosti, S., Allen, L.H., Dewey, K.G. 2019. Prenatal iron deficiency and replete iron status are associated with adverse birth outcomes, but associations differ in Ghana and Malawi. Journal of Nutrition. 149(3):513-521. https://doi.org/10.1093/jn/nxy278.Prevalence of low serum vitamin B12 in Mexican children and women: results from the first National Nutrition Survey (1999) as a basis for interventions and progress-(Peer Reviewed Journal) Anaya-Loyola, M., Brito, A., Villalpando, S., Allen, L.H. 2019. Prevalence of low serum vitamin B12 in Mexican children and women: results from the first National Nutrition Survey (1999) as a basis for interventions and progress. International Journal for Vitamin and Nutrition Research. https://doi.org/10.1024/0300-9831/a000579.Effects of lipid-based nutrient supplements and infant and young child feeding counseling with or without improved water, sanitation, and hygiene (WASH) on anemia and micronutrient status-(Peer Reviewed Journal) Stewart, C.P., Dewey, K.G., Lin, A., Pickering, A.J., Byrd, K.A., Jannat, K., Ali, S., Rao, G., Dentz, H.N., Kiprotich, M., Arnold, C.D., Arnold, B.F., Allen, L.H., Shahab-Ferdows, S., Ercumen, A., Grembi, J.A., Naser, A.M., Rahman, M., Unicomb, L., Colford, J.M., Luby, S.P., Null, C. 2019. Effects of lipid-based nutrient supplements and infant and young child feeding counseling with or without improved water, sanitation, and hygiene (WASH) on anemia and micronutrient status. American Journal of Clinical Nutrition. 109(1):148-164. https://doi.org/10.1093/ajcn/nqy239.Water-soluble vitamins in human milk: factors affecting their concentration and their physiological significance-() Allen, L.H., Hampel, D. 2019. Water-soluble vitamins in human milk: factors affecting their concentration and their physiological significance. In: Donovan,S.M., German, J.B., Lönnerdal, B, Lucas, A., editors. Human Milk: Composition, Clinical Benefits and Future Opportunities. Lausanne, Switzerland. Nestle Nutrition Workshop. 90:69-81. https://doi.org/10.1159/000490296.Vitamin B12 added as a fortificant to flour retains high bioavailability when baked in bread-(Peer Reviewed Journal) Garrod, M.G., Buchholz, B.A., Miller, J.W., Haack, K.W., Green, R., Allen, L.H. 2018. Vitamin B12 added as a fortificant to flour retains high bioavailability when baked in bread. Nuclear Instruments and Methods. https://doi.org/10.1016/j.nimb.2018.05.042.Vitamin B12 added as a fortificant to flour retains high bioavailability when baked in bread-(Peer Reviewed Journal) Garrod, M.G., Buchholz, B.A., Miller, J.W., Haack, K.W., Green, R., Allen, L.H. 2018. Vitamin B12 added as a fortificant to flour retains high bioavailability when baked in bread. Nuclear Instruments and Methods in Physics Research. 438:136-140. https://doi.org/10.1016/j.nimb.2018.05.042.Impact of an 8-week controlled feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indices-(Peer Reviewed Journal) Krishnan, S., Adams, S.H., Allen, L.H., Laugero, K.D., Newman, J.W., Stephensen, C.B., Burnett, D.J., Witbracht, M.G., Welch, L.C., Que, E.S., Keim, N.L. 2018. Impact of an 8-week controlled feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indices. American Journal of Clinical Nutrition. 108(2):266-278. https://doi.org/10.1093/ajcn/nqy113.Vitamin B12 in breast milk: a systematic review-(Peer Reviewed Journal) Dror, D., Allen, L.H. 2018. Vitamin B12 in breast milk: a systematic review. Advances in Nutrition. 9:358S-366S. https://doi.org/10.1093/advances/nmx019.Retinol to fat ratio and retinol in human milk: a systematic review and meta-analysis-(Peer Reviewed Journal) Dror, D., Allen, L.H. 2018. Retinol to fat ratio and retinol in human milk: a systematic review and meta-analysis. Advances in Nutrition. 9:332S-346S. https://doi.org/10.1093/advances/nmy021.Vitamin B12 content in breast milk of vegan, vegetarian and non-vegetarian lactating women in the United States-(Peer Reviewed Journal) Allen, L.H., Pawlak, R., Vos, P., Shahab-Ferdows, S., Hampel, D., Perrin, M.T. 2018. Vitamin B12 content in breast milk of vegan, vegetarian and non-vegetarian lactating women in the United States. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqy104.Methods to assess vitamin B-12 bioavailability and technologies to enhance its absorption-(Peer Reviewed Journal) Brito, A., Habevch, E., Silva-Zolezzi, I., Galaffu, N., Allen, L.H. 2018. Methods to assess vitamin B-12 bioavailability and technologies to enhance its absorption. Nutrition Reviews. 76(10):778-792. https://doi.org/10.1093/nutrit/nuy026.Associations between school readiness and obesity- and inflammation-related biomarkers in low-income preschoolers within the healthy kids study-(Peer Reviewed Journal) Sutter, C., Ontai, L.L., Shilts, M.K., Lanoue, L., Allen, L.H., Townsend, M.S. 2018. Associations between school readiness and obesity- and inflammation-related biomarkers in low-income preschoolers within the healthy kids study. Mind, Brain, and Education. 12:28-38. https://doi/pdf/10.1111/mbe.12165.Using dietary reference values to define fortification levels for national programs-() Allen, L.H. 2018. Using dietary reference values to define fortification levels for national programs. Book Chapter. 43-50. https://doi.org/10.1016/B978-0-12-802861-2.00004-3.Co-causation of reduced newborn size by maternal undernutrition, infections, and inflammation-(Peer Reviewed Journal) Ashorn, P., Hallamaa, L., Allen, L.H., Ashorn, U., Chandrasiri, U., Deitchler, M., Doyle, R., Harjunmaa, U., Jorgensen, J.M., Kamiza, S., Klein, N., Maleta, K., Nkhoma, M., Oaks, B.M., Poelman, B., Rogerson, S.J., Stewart, C.P., Zeilani, M., Dewey, K.G. 2018. Co-causation of reduced newborn size by maternal undernutrition, infections, and inflammation. Maternal and Child Nutrition. 14(3):e12585. doi.org/10.1111/mcn.12585.Infant serum and maternal milk vitamin B-12 are positively correlated in Kenyan infant-mother dyads at 1–6 months postpartum, irrespective of infant feeding practice-(Peer Reviewed Journal) Williams, A.M., Stewart, C.P., Shahab-Ferdows, S., Hampel, D., Kiprotich, M., Achando, B., Lin, A., Null, C., Allen, L.H., Chantry, C.J. 2018. Infant serum and maternal milk vitamin B-12 are positively correlated in Kenyan infant-mother dyads at 1–6 months postpartum, irrespective of infant feeding practice. Journal of Nutrition. 148:86-93. https://doi.org/10.1093/jn/nxx009.Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults-(Peer Reviewed Journal) Baldiviez, L.M., Keim, N.L., Laugero, K.D., Hwang, D.H., Huang, L., Woodhouse, L.R., Burnett, D.J., Zerofsky, M., Bonnel, E., Allen, L.H., Newman, J.W., Stephensen, C.B. 2017. Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults. Biomed Central (BMC) Nutrition. 3(79):1-13. https://doi.org/10.1186/s40795-017-0197-4.Associations of maternal nutrition during pregnancy and postpartum with maternal cognition and caregiving-(Abstract Only) Prado, E., Ashorn, U., Phuka, J., Maleta, K., Sadalaki, J., Oaks, B., Haskell, M., Allen, L.H., Vosti, S., Ashorn, P., Dewey, K. 2017. Associations of maternal nutrition during pregnancy and postpartum with maternal cognition and caregiving. Experimental Biology. DOI: 10.1111/mcn.12546.Associations of maternal nutrition during pregnancy and postpartum with maternal cognition and mother-child interaction-(Peer Reviewed Journal) Prado, E., Ashorn, U., Phuka, .J., Maleta, .K., Sadalaki, .J., Oaks, B.M., Haskell, M., Allen, L.H., Vosti, S.A., Ashorn, .P., Dewey, K.G. 2018. Associations of maternal nutrition during pregnancy and postpartum with maternal cognition and mother-child interaction. Maternal and Child Nutrition. 14:e12546. https://doi.org/10.1111/mcn.12546.Vegetable behavioral tool demonstrates validity with MyPlate vegetable cups and carotenoid and inflammatory biomarkers-(Peer Reviewed Journal) Townsend, M.S., Shilts, M.K., Styne, D.M., Drake, C., Lanoue, L., Woodhouse, L.R., Allen, L.H. 2016. Vegetable behavioral tool demonstrates validity with MyPlate vegetable cups and carotenoid and inflammatory biomarkers. Appetite. 107:628-638. doi: 10.1016/j.appet.2016.09.002.Efficacy and safety of vitamin B12 fortification-() Allen, L.H. 2018. Efficacy and safety of vitamin B12 fortification. Book Chapter. https://doi.org/10.1016/B978-0-12-802861-2.00026-2.The effects of a lipid-based nutrient supplement and antiretroviral therapy in a randomized controlled trial on iron, copper, and zinc in milk from HIV+ Malawian mothers and associations with maternal and infant biomarkers-() Hampel, D., Shahab-Ferdows, S., Gertz, E.R., Flax, V.L., Adair, L.S., Bentley, M.E., Jamieson, D.J., Tegha, G., Chasela, C.S., Kamwendo, D., Van Der Horst, C.M., Allen, L.H. 2017. The effects of a lipid-based nutrient supplement and antiretroviral therapy in a randomized controlled trial on iron, copper, and zinc in milk from HIV+ Malawian mothers and associations with maternal and infant biomarkers. Maternal and Child Nutrition. 14(2):e12503. https://doi.org/10.1111/mcn.12503.The human serum metabolome of vitamin B-12 deficiency and repletion, and associations with neurological function-(Peer Reviewed Journal) Brito, A., Grapov, D., Fahrmann, J., Harvey, D., Green, R., Miller, J.W., Fedosov, S.N., Shahab-Ferdows, S., Hampel, D., Pedersen, T.L., Fiehn, O., Newman, J.W., Uauy, R., Allen, L.H. 2017. The human serum metabolome of vitamin B-12 deficiency and repletion, and associations with neurological function. Journal of Nutrition. 147(10):1839-1849. https://doi.org/10.3945/jn.117.248278.Overview of nutrients in breast milk-(Peer Reviewed Journal) Dror, D.K., Allen, L.H. 2018. Overview of nutrients in breast milk. Advances in Nutrition. 9:278S-294S. https://doi.org/10.1093/advances/nmy022.Vitamin B12 deficiency-() Green, R., Allen, L.H., Bjorke-Monsen, A., Brito, A., Gueant, J., Miller, J.W., Molly, A.M., Nexo, E., Stabler, S., Toh, B., Ueland, P.M., Yajnik, C. 2017. Vitamin B12 deficiency. Nature Review Disease Primers. doi: 10.1038/nrdp.2017.40.Limitations of the evidence base used to set recommended nutrient intakes for infants and lactating women.-(Peer Reviewed Journal)Iron, zinc, folate, and vitamin B12 status increased among women and children in Yaounde and Douala, Cameroon, one year after introducing fortified wheat flour-(Peer Reviewed Journal) Engle-Stone, R., Nankap, M., Ndjebayi, A.O., Allen, L.H., Shahab-Ferdows, S., Hampel, D., Killilea, D.W., Gimou, M., Houghton, L.A., Friedman, A., Tarini, A., Stamm, R.A., Brown, K.H. 2017. Iron, zinc, folate, and vitamin B12 status increased among women and children in Yaounde and Douala, Cameroon, one year after introducing fortified wheat flour. Journal of Nutrition. 147(7):1426-1436. doi: 10.3945/jn.116.245076.Correlations between maternal, breast milk, and infant vitamin B12 concentrations among mother-infant dyads in Vancouver, Canada and Pry Veng, Cambodia: an exploratory analysis-(Peer Reviewed Journal) Chebaya, P., Karakochuk, C.D., March, K.M., Chen, N.N., Stamm, R.A., Kroeun, H., Sophonneary, P., Borath, M., Shahab-Ferdows, S., Hampel, D., Barr, S.I., Lamers, Y., Houghton, L.A., Allen, L.H., Green, T., Whitfield, K.C. 2017. Correlations between maternal, breast milk, and infant vitamin B12 concentrations among mother-infant dyads in Vancouver, Canada and Pry Veng, Cambodia: an exploratory analysis. Nutrients. 9(3):270. doi: 10.3390/nu.9030270.Micronutrients in human milk: analytical methods-(Peer Reviewed Journal) Hampel, D., Dror, D., Allen, L.H. 2018. Micronutrients in human milk: analytical methods. Advances in Nutrition. 9:313S-331S. https://doi.org/10.1093/advances/nmy017.Iodine in breast milk: a systematic review-(Peer Reviewed Journal) Dror, D., Allen, L.H. 2018. Iodine in breast milk: a systematic review. Advances in Nutrition. 9:347S-357S. https://doi.org/10.1093/advances/nmy020.Introduction to current knowledge on micronutrients in human milk: adequacy, analysis and need for research-(Peer Reviewed Journal) Allen, L.H., Dror, D.K. 2018. Introduction to current knowledge on micronutrients in human milk: adequacy, analysis and need for research. Advances in Nutrition. 9:275S-277S. https://doi.org/10.1093/advances/nmy018.Association between early pregnancy vitamin D status and changes in serum lipid profiles throughout pregnancy-(Peer Reviewed Journal) Lepsch, J., Eschriqui, I., Rodriguez-Farias, D., Vaz, J.S., Cunha Figueiredo, A.C., Amorim Adegboye, A.R., Brito, A., Mokhtar, R., Allen, L.H., Holick, M.F., Kac, G. 2017. Association between early pregnancy vitamin D status and changes in serum lipid profiles throughout pregnancy. Metabolism. 70:85-97. https://doi.org/10.1016/j.metabol.2017.02.004.Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25 dihydroxyvitamin D during pregnancy: a Brazilian cohort.-(Peer Reviewed Journal) Figueiredo, A., Cocate, P., Adegboye, A., Franco-Sena, A., Farias, D., Trinidade De Castro, M., Brito, A., Allen, L.H., Mokhtar, R., Holick, M., Kac, G. 2018. Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25 dihydroxyvitamin D during pregnancy: a Brazilian cohort. European Journal of Nutrition. 57:1059-1072. https://doi.org/10.1007/s00394-017-1389-z.Fat- and water-soluble vitamin concentrations in human milk: effects of collection protocol, circadian variation and acute maternal supplementation-(Peer Reviewed Journal) Hampel, D., Shahab-Ferdows, S., Islam, M.M., Peerson, J.M., Allen, L.H. 2017. Fat- and water-soluble vitamin concentrations in human milk: effects of collection protocol, circadian variation and acute maternal supplementation. Journal of Nutrition. doi: 10.3945:jn.116.242941.Vitamin concentrations in human milk vary with time within feed, circadian rhythm, and single-dose supplementation-(Peer Reviewed Journal) Hampel, D., Shahab-Ferdows, S., Islam, M., Peerson, J.M., Allen, L.H. 2017. Vitamin concentrations in human milk vary with time within feed, circadian rhythm, and single-dose supplementation. Journal of Nutrition. 147(4):603-611. doi: 10.3945/jn.116.242941.Biomarkers of Nutrition for Development (BOND) - vitamin B12 review-(Peer Reviewed Journal) Allen, L.H., Miller, J.W., De Groot, L., Rosenberg, I.H., Smith, D.A., Refsum, H., Raiten, D.J. 2018. Biomarkers of Nutrition for Development (BOND) - vitamin B12 review. Journal of Nutrition. 148(4):1995S-2027S. https://doi.org/10.1093/jn/nxy201.Perinatal consumption of thiamine-fortified fish sauce in rural Cambodia. A randomized clinical trial-(Peer Reviewed Journal) Whitfield, K.C., Karakochuk, C.D., Kroeun, H., Hampel, D., Sokhonig, L., Chan, B.B., Borath, M., Sophonneary, P., Mclean, J., Talukder, A., Lynd, L.D., Li-Chan, E.C., Kitts, D.D., Allen, L.H., Green, T.J. 2016. Perinatal consumption of thiamine-fortified fish sauce in rural Cambodia. A randomized clinical trial. JAMA Pediatrics. 170(10):e162065.Vitamin B-12 concentrations in breast milk are low and are not associated with reported household hunger, recent animal source food or vitamin B-12 intake among women in rural Kenya-(Peer Reviewed Journal) Williams, A.M., Chantry, C.J., Young, S.L., Allen, L.H., Arnold, B.F., Colford Jr, J.M., Dentz, H.N., Hampel, D., Lin, A., Null, C.A., Shahab-Ferdows, S., Stewart, C. 2016. Vitamin B-12 concentrations in breast milk are low and are not associated with reported household hunger, recent animal source food or vitamin B-12 intake among women in rural Kenya. Journal of Nutrition. 146(5)1125-1131. doi: 10.3945/jn.115.228189.Analyzing B-vitamins in human milk: methodological approaches-(Peer Reviewed Journal) Hampel, D., Allen, L.H. 2016. Analyzing B-vitamins in human milk: methodological approaches. Critical Reviews in Food Science and Nutrition. 56:494-511. https://doi.org/10.1080/10408398.2013.783550.Reply to Lawrence R. Solomon: Negative interaction of high folate status with biochemical and neurological response to vitamin B-12 treatment-(Peer Reviewed Journal) Brito, A., Fedosov, S.N., Miller, J.W., Green, R., Uauy, R., Allen, L.H. 2016. Reply to Lawrence R. Solomon: Negative interaction of high folate status with biochemical and neurological response to vitamin B-12 treatment. American Journal of Clinical Nutrition. 103(5):1379. doi: 10.3945/ajcn.116.133322.Thiamin and riboflavin vitamers in human milk: effects of lipid-based nutrient supplementation and stage of lactation on vitamer secretion and contributions to total vitamin content-(Peer Reviewed Journal) Hampel, D., Shahab-Ferdows, S., Adair, L.S., Bentley, M.E., Flax, V.L., Jamieson, D.J., Ellington, S.R., Tegha, G., Chasela, C.S., Kamwendo, D., Allen, L.H. 2016. Thiamin and riboflavin vitamers in human milk: effects of lipid-based nutrient supplementation and stage of lactation on vitamer secretion and contributions to total vitamin content. PLoS One. doi: 10.1371/journal.pone.0149479.Current information gaps in micronutrient research, programs and policy: how can we fill them?-() Allen, L.H. 2016. Current information gaps in micronutrient research, programs and policy: how can we fill them? In: Biesalski, H.K., Black, R.E., editors. World Review of Nutrition and Dietetics, Volume 115. Hidden Hunger. Baltimore, MD: Karger Publishers. p. 109-117.Vitamin B-12 treatment of asymptomatic, deficient, elderly Chileans improves conductivity in myelinated periphreal nerves, but high serum folate impairs vitamin B-12 status response assessed by the combined indicator of..-(Peer Reviewed Journal) Brito, A., Miller, J.W., Green, R., Fedosov, S.N., Harvey, D., Shahab-Ferdows, S., Verdugo, R., Sanchez, H., Albala, C., Uauay, R., Allen, L.H. 2016. Vitamin B-12 treatment of asymptomatic, deficient, elderly Chileans improves conductivity in myelinated periphreal nerves, but high serum folate impairs vitamin B-12 status response assessed by the combined indicator of vitamin B-12 status. American Journal of Clinical Nutrition. 103:250-257. doi: 10.3945/ajcn.115.116509.Vitamin B-12 in breast milk and diet, and riboflavin in breastmilk, are very low in Kenyan lactating women, although vitamin B-6 is sufficient.-(Abstract Only) Williams, A., Chantry, C., Stewart, C., Hampel, D., Allen, L.H., Young, S., Shahab-Ferdows, S. 2016. Vitamin B-12 in breast milk and diet, and riboflavin in breastmilk, are very low in Kenyan lactating women, although vitamin B-6 is sufficient.. Meeting Abstract. 18th Int. Society for Res. in Human Milk and Lactation Conf., Stellenbosch, S. Africa, 3/3-7/16.Maternal consumption of thiamin-fortified fish sauce during pregnancy and lactation improves maternal and infant thiamin status and breast milk thiamin concentrations.-(Abstract Only) Whitfield, K.C., Karakochuk, C.D., Hampel, D., Kroeun, H., Lynd, L.D., Li-Chan, E.Y., Kitts, D.D., Allen, L.H., Green, T.J. 2016. Maternal consumption of thiamin-fortified fish sauce during pregnancy and lactation improves maternal and infant thiamin status and breast milk thiamin concentrations.. Meeting Abstract. 18th Int. Soc. for Res. in Human Milk and Lactation Conf.Stellenbosch, S. Africa, 3/3-7/16.Folate and vitamin B12 status in Latin America and the Caribbean: An update-(Peer Reviewed Journal) Brito, A., Mujica-Coopman, M.F., Olivares, M., Lopez De Romana, D., Cori, H., Allen, L.H. 2015. Folate and vitamin B12 status in Latin America and the Caribbean: An update. Food and Nutrition Bulletin. 2015, Vol. 36(Supplement 2); DOI: 10.1177/0379572115585772.Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status, and recommendations for revised cut-points-(Peer Reviewed Journal) Fedosov, S.N., Britio, A., Miller, J.W., Green, R., Allen, L.H. 2015. Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status, and recommendations for revised cut-points. Clinical Chemistry. 53(8):1215-1225.Plasma micronutrient concentrations are altered by antiretroviral therapy and lipid-based nutrient supplements in lactating HIV-infected Malawian women-(Peer Reviewed Journal) Flax, V.L., Adair, L.S., Allen, L.H., Shahab-Ferdows, S., Hampel, D., Chasela, C.S., Tegha, G., Daza, E.J., Corbett, A., Davis, N.L., Kamewendo, D., Kourtis, A.P., Van Der Horst, C.M., Jamieson, D.J., Bentley, M.E. 2015. Plasma micronutrient concentrations are altered by antiretroviral therapy and lipid-based nutrient supplements in lactating HIV-infected Malawian women. Journal of Nutrition.  DOI: 10.3945/jn.115.212290.Symposium report: Effective and safe micronutrient interventions, weighing the risks against the benefits-(Proceedings) Bielderman, I., Bruins, M.J., Engle-Stone, R., Solomons, N.W., Verhagen, H., Allen, L.H., Neufeld, L.M., Kraemer, K., Badham, J. 2015. Symposium report: Effective and safe micronutrient interventions, weighing the risks against the benefits . European Journal of Nutrition & Food Safety. 5(4): 202-228, EJNFS.2015.019.Maternal Deworming Research Study (MADRES) protocol: a double-blind, placebo-controlled randomised trial to determine the effectiveness of deworming in the immediate postpartum period-(Peer Reviewed Journal) Mofid, L.S., Casapia, M., Montresor, A., Rahme, E., Fraser, W.D., Marquis, G.S., Vercruysse, J., Allen, L.H., Gyorkos, T.W. 2015. Maternal Deworming Research Study (MADRES) protocol: a double-blind, placebo-controlled randomised trial to determine the effectiveness of deworming in the immediate postpartum period. BMJ Open. 5:e008560.  DOI: 10.1136/bmjopen-2015-008560.Maternal Deworming Research Study (MADRES) protocol: a double-blind, placebo-controlled randomised trial to determine the effectiveness of deworming in the immediate postpartum period-(Peer Reviewed Journal) Mofid, L.S., Casapia, M., Montresor, A., Rahme, E., Fraser, W.D., Marquis, G.S., Vercruysse, J., Allen, L.H., Gyorkos, T.W. 2016. Maternal Deworming Research Study (MADRES) protocol: a double-blind, placebo-controlled randomised trial to determine the effectiveness of deworming in the immediate postpartum period. BMJ Open. doi:10.1136/bmjopen-2015-008560.Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh-(Peer Reviewed Journal) Siddiqua, T.J., Ahmad, S.M., Ahsan, K.B., Rashid, M., Roy, A., Rahman, S.M., Shahab-Ferdows, S., Hampel, D., Ahmed, T., Allen, L.H., Raqib, R. 2015. Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh. European Journal of Nutrition. 54:1-13. https://doi.org/10.1007/s00394-015-0845-x.Global dietary patterns and diets in childhood: implications for health outcomes-(Peer Reviewed Journal) Allen, L.H. 2013. Global dietary patterns and diets in childhood: implications for health outcomes. Annals of Nutrition and Metabolism. 61 (suppl. 1):29-37.Micronutrient research, programs and policy: from meta-analyses to metabolomics-(Peer Reviewed Journal) Allen, L.H. 2014. Micronutrient research, programs and policy: from meta-analyses to metabolomics. Advances in Food and Nutrition Research. 5(3):344S-351S. https://doi.org/10.3945/an.113.005421.Global dietary patterns and diets in childhood: implications for health outcomes-(Peer Reviewed Journal) Allen, L.H. 2013. Global dietary patterns and diets in childhood: implications for health outcomes. Annals of Nutrition and Metabolism. 61:29-37. DOI: 10.1159/000346185.Effect of supplementation with a lipid-based nutrient supplement on the micronutrient status of children aged 6–18 months living in the rural region of Intibucá, Honduras-(Peer Reviewed Journal) Anna Maria, S., Del Campo, Y.E., Kinlaw, A., Reinhart, G., Allen, L.H., Shahab-Ferdows, S., Heck, J., Suchindran, C., Bentley, M. 2014. Effect of supplementation with a lipid-based nutrient supplement on the micronutrient status of children aged 6–18 months living in the rural region of Intibucá, Honduras. Paediatric and Perinatal Epidemiology. 28:245-254. DOI: 10.1111/ppe.12117.Competitive chemiluminescent enzyme immunoassay for vitamin B12 analysis in human milk-(Peer Reviewed Journal) Hampel, D., Shahab-Ferdows, S., Domek, J.M., Siddiqua, T., Raqib, R., Allen, L.H. 2013. Competitive chemiluminescent enzyme immunoassay for vitamin B12 analysis in human milk. Journal of Food Chemistry. DOI: 10.1016/j_foodchem.2013.12.033.Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS)-(Peer Reviewed Journal) Arimond, M., Zeilani, M., Jungjohann, S., Brown, K., Ashorn, P., Allen, L.H., Dewey, K.G. 2013. Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS). Maternal and Child Nutrition. DOI: 10.1111/mcn.12049.Predicted efficacy of the Palestinian wheat flour fortification program: complementary analysis of biochemical and dietary data-(Peer Reviewed Journal) Dary, O., Rambelson, Z., Shahab-Ferdows, S., Dror, D., Allen, L.H., Carriquiry, A., Salman, R. 2014. Predicted efficacy of the Palestinian wheat flour fortification program: complementary analysis of biochemical and dietary data. Public Health Nutrition. 18:1950-1957.Combined indicator of vitamin B 12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points-(Peer Reviewed Journal) Fedosov, S.N., Brito, A., Miller, J., Green, R., Allen, L.H. 2015. Combined indicator of vitamin B 12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points. Clinical Chemistry and Laboratory Medicine.  DOI: 10.1515/cclm-2014-0818.Micronutrient supplements during pregnancy and/or lactation in Malawi and Ghana increase breast milk B-vitamins [abstract]-(Abstract Only) Shahab-Ferdows, S., Hampel, D., Dewey, K., Ashorn, P., Bentley, M., Adair, L., Flax, V., Allen, L.H. 2014. Micronutrient supplements during pregnancy and/or lactation in Malawi and Ghana increase breast milk B-vitamins [abstract]. Micronutrient Forum Global Conference. doi:10.4172:2161-0509.1000142.Changes in soluble transferrin receptor and hemoglobin concentrations in Malawian mothers are associated with those values in their exclusively breastfed, HIF-exposed infants-(Peer Reviewed Journal) Widen, E.M., Bentley, M.E., Kayira, D., Chasela, C.S., Daza, E.J., Kacheche, Z.K., Tegha, G., Jamieson, D.J., Kourtis, A.P., Van Der Horst, C.M., Allen, L.H., Shahab-Ferdows, S., Adair, L.S. 2013. Changes in soluble transferrin receptor and hemoglobin concentrations in Malawian mothers are associated with those values in their exclusively breastfed, HIF-exposed infants. Journal of Nutrition. 144(3):367-74. doi: 10.3945/jn.113.177915.Changes in soluble transferrin receptor and hemoglobin concentrations in Malawian mothers are associated with those values in their exclusively breastfed, HIV-exposed infants-(Peer Reviewed Journal) Widen, E.M., Bentley, M.E., Kayira, D., Chasela, C., Daza, E.J., Kacheche, Z.K., Tegha, G., Jamieson, D.J., Kourtis, A.P., Van Der Horst, C.M., Allen, L.H., Shahab-Ferdows, S., Adair, L. 2013. Changes in soluble transferrin receptor and hemoglobin concentrations in Malawian mothers are associated with those values in their exclusively breastfed, HIV-exposed infants. Journal of Nutrition. 144(3):367-373. https://doi.org/10.3945/jn.113.177915.Competitive chemiluminescent enzyme immunoassay for vitamin B12 analysis in human milk-(Peer Reviewed Journal) Hampel, D., Shahab-Ferdows, S., Domek, J.M., Siddiqua, T., Raqib, R., Allen, L.H. 2013. Competitive chemiluminescent enzyme immunoassay for vitamin B12 analysis in human milk. Journal of Food Chemistry. 153:60-65. https://doi.org/10.1016/j.foodchem.2013.12.033.Dairy product intake in children and adolescents in developed countries: trends, nutritional contribution, and a review of association with health outcomes-() Dror, D.K., Allen, L.H. 2014. Dairy product intake in children and adolescents in developed countries: trends, nutritional contribution, and a review of association with health outcomes. Nutrition Reviews. 72 (2):68-81. https://doi.org/10.1111/nure.12078.Developmental effects of micronutrient supplementation and malaria in Zanzibari children-(Peer Reviewed Journal) Olney, D.K., Kariger, P.K., Stolzfus, R.J., Allen, L.H. 2013. Developmental effects of micronutrient supplementation and malaria in Zanzibari children. Early Human Development. 89:667-674. DOI: 10.1016/j_earlhumdev.2013.04.013.Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project-(Peer Reviewed Journal) Arimond, M., Zeilani, M., Jungjohann, S., Brown, K.H., Ashorn, P., Allen, L.H., Dewey, K.G. 2013. Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project. Maternal and Child Nutrition. 11(4):31-61. https://doi.org/10.1111/mcn.12049.Ultra-performance liquid chromatography tandem mass-spectrometry (uplc-ms/ms) for the rapid, simultaneous analysis of thiamin, riboflavin, flavin adenine dinucleotide, nicotinamide and pyridoxal in human milk-(Peer Reviewed Journal) Hampel, D., York, E.R., Allen, L.H. 2012. Ultra-performance liquid chromatography tandem mass-spectrometry (uplc-ms/ms) for the rapid, simultaneous analysis of thiamin, riboflavin, flavin adenine dinucleotide, nicotinamide and pyridoxal in human milk. Journal of Chromatography B. 903 p. 7-13.Vitamin B-12-() Allen, L.H. 2012. Vitamin B-12. Advances in Nutrition. 3:54-55.Vitamin B-12 supplementation of rural Mexican women changes biochemical B-12 status indicators but does not affect hematology or a bone turnover marker-(Peer Reviewed Journal) Shahab-Ferdows, S., Anaya-Loyola, M.A., Vergara-Castaneda, H., Rosado, J., Keyes, W.R., Newman, J.W., Miller, J., Allen, L.H. 5012. Vitamin B-12 supplementation of rural Mexican women changes biochemical B-12 status indicators but does not affect hematology or a bone turnover marker. Journal of Nutrition. vol. 142, no. 10, 1881-1887.Pros and cons of increasing folic acid and vitamin B12 intake by fortification-() Allen, L.H. 2012. Pros and cons of increasing folic acid and vitamin B12 intake by fortification. Nestle Nutrition Workshop. Vol. 70, p. 38-39.Folate, vitamin B12 and human health-(Peer Reviewed Journal) Brito, A., Hertrampf, E., Olivares, M., Diego, G., Sanchez, H., Uauy, R., Allen, L.H. 2012. Folate, vitamin B12 and human health. Journal Revista Medica de Chile. 140(11):1464-1475. https://doi.org/10.4067/S0034-98872012001100014.Adequacy of family foods for complementary feeding-() Allen, L.H. 2012. Adequacy of family foods for complementary feeding. American Journal of Clinical Nutrition. Vol. 45, No. 4, 785-86.Evidence of associations between feto-maternal vitamin D status, cord parathyroid hormone and bone-specific alkaline phosphatase, and newborn whole body bone mineral content-(Peer Reviewed Journal) Dror, D.K., King, J.C., Fung, E.B., Van Loan, M.D., Gertz, E.R., Allen, L.H. 2012. Evidence of associations between feto-maternal vitamin D status, cord parathyroid hormone and bone-specific alkaline phosphatase, and newborn whole body bone mineral content. Nutrients. 4:68-77.Breast milk vitamin B-12 concentrations in Guatemalan women are correlated with maternal but not infant vitamin B–12 status at 12 months postpartum-(Peer Reviewed Journal) Deegan, K., Jones, K., Zuleta, C., Ramirez-Zea, M., Lilliballe, D., Nexo, E., Allen, L.H. 2011. Breast milk vitamin B-12 concentrations in Guatemalan women are correlated with maternal but not infant vitamin B–12 status at 12 months postpartum. Journal of Nutrition. 142:112-116. https://doi.org/10.3945/jn.111.143917.Comparison of two modes of vitamin B12 supplementation on neuroconduction and cognitive function among older people living in Sandiago, Chile: A cluster randomized controlled trial. A study protocol(ISRCTN 02694183)-() Sanchez, H. 2011. Comparison of two modes of vitamin B12 supplementation on neuroconduction and cognitive function among older people living in Sandiago, Chile: A cluster randomized controlled trial. A study protocol(ISRCTN 02694183). Nutrition Journal. 10:100.Maternal nutrient metabolism and requirements in pregnancy and lactation-() Allen, L.H. 2012. Maternal nutrient metabolism and requirements in pregnancy and lactation. Present Knowledge in Nutrition  Book Chapter. DOI: 10.1002/9781119946045.ch39. https://doi.org/10.1002/9781119946045.ch39.Interventions with vitamins B6, B12 and C in pregnancy-(Peer Reviewed Journal) Dror, D.K., Allen, L.H. 2012. Interventions with vitamins B6, B12 and C in pregnancy. PAEDIATRIC AND PERINATAL EPIDEMIOLOGY. 26 (Suppl. 1), 55-74.An optimized method for measuring methylmalonic acid in low volumes of serum using UPLC-MS/MS-(Peer Reviewed Journal) Pedersen, T.L., Keyes, W.R., Shahab-Ferdows, S., Allen, L.H., Newman, J.W. 2011. An Optimized Method for Measuring Methylmalonic Acid in Low Volumes of Serum Using UPLC-MS/MS. Journal of Chromatography. B. 879, 1502-6.The importance of milk and other animal-source foods for children in low-income countries-(Peer Reviewed Journal) Dror, D.K., Allen, L.H. 2011. The importance of milk and other animal-source foods for children in low-income countries. Food and Nutrition Bulletin. 32(3):227-243. https://doi.org/10.1177/156482651103200307.Feto-maternal vitamin D status and infant whole-body bone mineral content in the first weeks of life-(Peer Reviewed Journal) Dror, D.K., King, J.C., Durand, D.J., Fung, E.B., Allen, L.H. 2012. Feto-maternal vitamin D status and infant whole-body bone mineral content in the first weeks of life. European Journal of Clinical Nutrition. 66:1016-1019. https://doi.org/10.1038/ejcn.2012.79.Effects of animal source foods, with emphasis on milk, in the diet of children in low-income countries-(Proceedings) Allen, L.H., Dror, D.K. 2011. Effects of animal source foods, with emphasis on milk, in the diet of children in low-income countries. Nestle Nutrition Workshop. Proceedings of Nestle Institute Workshop Series Pediatric Program, Vol 67, pp 113-130.Vitamin E deficiency in developing countries-() Dror, D.K., Allen, L.H. 2011. Vitamin E deficiency in developing countries. Food and Nutrition Bulletin. 32(2):124-143. https://doi.org/10.1177/156482651103200206.The micronutrient genomics project: a community-driven knowledge base for micronutrient research-(Peer Reviewed Journal) Van Ommen, B., El-Sohemy, A., Hesketh, J., Kaput, J., Fenech, M., Evelo, T., Mcardle, H.J., Bouwman, J., Lietz, G., Mathers, J.C., Fairweather-Tait, S., Van Kranen, H., Elliott, R., Wopereis, S., Ferguson, L.R., Meplan, C., Perozzi, G., Allen, L.H. 2010. The micronutrient genomics project: a community-driven knowledge base for micronutrient research. . 5(4):285-296.Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions-(Peer Reviewed Journal) Dror, D.K., Allen, L.H. 2010. Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions. Nutrition Reviews. 68(8):465-477.Association of modifiable and nonmodifiable factors with vitamin D status in pregnant women and neonates in Oakland, CA-(Peer Reviewed Journal) Dror, D.K., King, J.C., Durand, D.J., Allen, L.H. 2010. Association of modifiable and nonmodifiable factors with vitamin D status in pregnant women and neonates in Oakland, CA. Journal Of The American Dietetic Association. 111:111-16.Bioavailability of vitamin B12-(Peer Reviewed Journal) Allen, L.H. 2010. Bioavailability of vitamin B12. International Journal for Vitamin and Nutrition Research. 80(45):330-335. https://doi.org/10.1024/0300-9831/a000041.Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics-(Peer Reviewed Journal) Garrod, M.G., Allen, L.H., Haan, M.N., Green, R., Miller, J.W. 2010. Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics. European Journal of Clinical Nutrition. 64, 503-509.VITAMIN B-12 SUPPLEMENTATION OF DEFICIENT LACTATING GUATEMALAN WOMEN IMPROVES MATERNAL BUT NOT INFANT STATUS-(Peer Reviewed Journal)Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older hispanics-(Peer Reviewed Journal) Garrod, M.G., Allen, L.H., Haan, M.N., Green, R., Miller, J.W. 2010. Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older hispanics. European Journal of Clinical Nutrition. 64:503-509, 2010.Impact of multiple micronutrient vs. iron - folic acid supplements on maternal anemia and micronutrient status in pregnancy-(Peer Reviewed Journal) Allen, L.H., Peerson, J.M. 2009. Impact of multiple micronutrient vs. iron - folic acid supplements on maternal anemia and micronutrient status in pregnancy. Food and Nutrition Bulletin. Vol. 30, No. 4.Multiple micronutrient supplementation during pregnancy in low-income countries: Review of methods and characteristics of studies included in the meta-analysis-(Peer Reviewed Journal) Margetts, B.M., Fall, C.H., Ronsmans, C., Allen, L.H., Fisher, D.J. 2009. Multiple micronutrient supplementation during pregnancy in low-income countries: Review of methods and characteristics of studies included in the meta-analysis. Food and Nutrition Bulletin. 30:S517-S526.Considering the case for vitamin B12 fortification of flour-() Allen, L.H., Rosenberg, I.H., Oakley, G.P., Omenn, G.S. 2010. Considering the case for vitamin B12 fortification of flour. Food and Nutrition Bulletin. 31(1):S36-46.Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate-(Peer Reviewed Journal) Miller, J.W., Garrod, M.G., Allen, L.H., Haan, M.N., Green, R. 2009. Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate. American Journal of Clinical Nutrition. 90:1586-1592.Provision of multiple rather than two or fewer micronutrients more effectively improves growth and other outcomes in micronutrient-deficient children and adults-(Peer Reviewed Journal) Allen, L.H., Peerson, J.M., Olney, D.K. 2009. Provision of multiple rather than two or fewer micronutrients more effectively improves growth and other outcomes in micronutrient-deficient children and adults. Journal of Nutrition. 139: 1022-1030.Development of nutritionally at-risk young children is predicted by malaria, anemia, and stunting in Pemba, Zanzibar-(Peer Reviewed Journal) Olney, D.K., Kariger, P.K., Stoltzfus, R.J., Khalfan, S.S., Ali, N.S., Tielsch, J.M., Sazawal, S., Black, R., Pollitt, E., Allen, L.H. 2009. Development of nutritionally at-risk young children is predicted by malaria, anemia, and stunting in Pemba, Zanzibar. Journal of Nutrition. 139:763-772.How common is vitamin B12 deficiency?-(Peer Reviewed Journal) Allen, L.H. 2009. How common is vitamin B12 deficiency? American Journal of Clinical Nutrition.  89:693S-696S.High concentrations of haptocorrin interfere with routine measurement of cobalamins in human serum and milk. A problem and its solution.-(Peer Reviewed Journal) Lildballe, D.L., Hardlei, T.F., Allen, L.H., Nexo, E. 2009. High concentrations of haptocorrin interfere with routine measurement of cobalamins in human serum and milk. A problem and its solution. Clin. Chem. Lab Med., 47:182-187.Priority areas for research on the intake, composition and health effects of nuts and peanuts-(Peer Reviewed Journal) Allen, L.H. 2008. Priority areas for research on the intake, composition and health effects of nuts and peanuts. Journal of Nutrition. 138:9, 1736S-1756S, 2008.Priority areas for research on the intake, composition, and health effects of tree nuts and peanuts-(Proceedings) Allen, L.H. 2008. Priority areas for research on the intake, composition, and health effects of tree nuts and peanuts. Journal of Nutrition. 138: 1763S-1765S.FRACTION OF TOTAL PLASMA VITAMIN B12 BOUND TO TRANSCOBALAMIN CORRELATES WITH COGNITIVE FUNCTION IN ELDERLY LATINOS WITH DEPRESSIVE SYMPTOMS-(Peer Reviewed Journal) Garrod, M.G., Green, R., Allen, L.H., Mungas, D.M., Jagust, W.J., Haan, M.N., Miller, J.W. 2008. THE FRACTION OF TOTAL PLASMA VITAMIN B12 BOUND TO TRANSCOBALAMIN CORRELATES WITH COGNITIVE FUNCTION IN ELDERLY LATINOS WITH DEPRESSIVE SYMPTOMS. Clinical Chemistry.  54:7, 1210-1217, 2008.Maternal and child undernutrition: global and regional exposures and health consequences-(Peer Reviewed Journal) Black, R.E., Caulfield, L.E., Allen, L.H., Bhutta, Z.A., De Onis, M., Mathers, C., Ezzati, M., Rivera, J. 2008. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet. 371:243-260.To what extent can food-based approaches improve micronutrient status?-(Peer Reviewed Journal) Allen, L.H. 2008. To what extent can food-based approaches improve micronutrient status?. Trade Journal Publication. 17(S1):103-105.Young Zanzibari Children with Iron Deficiency, Iron Deficiency Anemia, Stunting, or Malaria Have Lower Motor Activity Scores and Spend Less Time in Locomotion-(Peer Reviewed Journal) Olney, D.K., Pollitt, E., Kariger, P.K., Khalfan, S.S., Ali, N.S., Tielsch, J.M., Sazawal, S., Black, R., Mast, D., Allen, L.H., Stoltzfus, R.J. 2007. Young Zanzibari Children with Iron Deficiency, Iron Deficiency Anemia, Stunting, or Malaria Have Lower Motor Activity Scores and Spend Less Time in Locomotion. Journal of Nutrition. 137:2756-2762, 2007.Limitations of current micronutrient status indicators-(Peer Reviewed Journal) Allen, L.H. 2009. Limitations of current micronutrient status indicators. Nutrition Reviews. 67:S21-23.Position of the American Dietetic Association: Nutrition and lifestyle for a healthy pregnancy outcome-(Peer Reviewed Journal) Kaiser, L.L., Allen, L.H. 2008. Position of the American Dietetic Association: Nutrition and lifestyle for a healthy pregnancy outcome. Journal Of The American Dietetic Association. 108:553-561.Comparison of plasma ferritin concentration versus the ratio of plasma transferrin receptor to ferritin in estimating body iron stores: results of 4 intervention trials-(Peer Reviewed Journal) Yang, Z., Dewey, K.G., Lonnerdal, B., Hernell, O., Chaparro, C., Adu-Afarwuah, S., Mclean, E.D., Cohen, R.J., Domellof, M., Allen, L.H., Brown, K. 2008. Comparison of plasma ferritin concentration versus the ratio of plasma transferrin receptor to ferritin in estimating body iron stores: results of 4 intervention trials. American Journal of Clinical Nutrition.  87:1892-1898, 2008.Causes of Vitamin B12 and Folate Deficiency-(Peer Reviewed Journal) Allen, L.H. 2008. Causes of Vitamin B12 and Folate Deficiency. Food and Nutrition Bulletin. 29(2)S20-S34.Review of the magnitude of folate and vitamin B12 deficiencies worldwide-(Peer Reviewed Journal) Mclean, E., Benoist, B., Allen, L.H. 2008. Review of the magnitude of folate and vitamin B12 deficiencies worldwide. Food and Nutrition Bulletin. 29(2):S38-S51.Effect of vitamin B12 deficiency on neurodevelopment in infants:  current knowledge and possible mechanisms-(Peer Reviewed Journal) Dror, D.K., Allen, L.H. 2008. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutrition Reviews. 66(5):250-255, 2008.Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet-(Peer Reviewed Journal) Jones, K.M., Ramirez-Zea, M., Zuleta, C., Allen, L.H. 2007. Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet. Journal of Nutrition. 1307:1307-1313.Supplementation with iron and riboflavin enhances dark adaptation response to vitamin A-fortified rice in iron-deficient, pregnant, night-blind Nepali women-(Peer Reviewed Journal) Graham, J.M., Haskell, M.J., Pandey, P., Peerson, J.M., Shrestha, R.K., Brown, K.H., Allen, L.H. 2007. Supplementation with iron and riboflavin enhances dark adaptation response to vitamin A-fortified rice in iron-deficient, pregnant, night-blind Nepali women. American Journal of Clinical Nutrition. 85:1375-1384Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging-(Peer Reviewed Journal) Haan, M.N., Miller, J.W., Aiello, A.E., Whitmer, R.A., Jagust, W.J., Mungas, D.M., Allen, L.H., Green, R. 2007. Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging. American Journal of Clinical Nutrition. 85:511-517.Low plasma vitamin B-12 in Kenyan school children is highly prevalent and improved by supplemental animal source foods-(Peer Reviewed Journal) Mclean, E.D., Allen, L.H., Neumann, C.G., Peerson, J.M., Siekmann, J.H., Murphy, S.P., Bwibo, N.O., Demment, M.W. 2007. Low plasma vitamin B-12 in Kenyan school children is highly prevalent and improved by supplemental animal source foods. Journal of Nutrition.  137:676-682, 2007.Application of nutrient intake values (NIVs)-(Peer Reviewed Journal) Vorster, H.H., Murphy, S.P., Allen, L.H., King, J.C. 2007. Application of nutrient intake values (NIVs). Food and Nutrition Bulletin. 28:S116-S122.Report of the World Health Organization Technical Consultation on Prevention and Control of Iron Deficiency in Infants and Young Children in Malaria-Endemic Areas-(Proceedings) Benoist, B., Fontaine, O., Lynch, S., Allen, L.H. 2007. Report of the World Health Organization Technical Consultation on Prevention and Control of Iron Deficiency in Infants and Young Children in Malaria-Endemic Areas. Food and Nutrition Bulletin Vol.28(4)S489-S490.Causes of nutrition-related public health problems of preschool children: Available diet.-() Allen, L.H. 2006. Causes of nutrition-related public health problems of preschool children: Available diet. Journal of Parenteral and Enteral Nutrition. 43:S8-S12.Combined iron and folic acid supplementation with or without zinc reduces time to walking unassisted among Zanzibari infants 5-11 months old-(Peer Reviewed Journal) Olney, D.K., Pollitt, E., Kariger, P.K., Khalfan, S.S., Ali, N.S., Tielsch, J.M., Sazawal, S., Black, R., Allen, L.H., Stoltzfus, R.J. 2006. Combined iron and folic acid supplementation with or without zinc reduces time to walking unassisted among Zanzibari infants 5-11 months old. Journal of Nutrition.  136:2427-2432, 2006.PREGNANCY AND LACTATION-() Allen, L.H. Pregnancy and lactation. Present Knowledge in Nutrition  Book Chapter. AG-PPKN-0909 R1 CH41 03-31-06 10:28:43INDIGENOUS PEOPLES’ FOOD SYSTEMS FOR HEALTH: FINDING INTERVENTIONS THAT WORK-(Peer Reviewed Journal) Kuhnlein, H., Erasmus, B., Kanashiro-Creed, H., Englberger, L., Okeke, C., Turner, N., Allen, L.H., Bhattacharjee, L. 2006. INDIGENOUS PEOPLES’ FOOD SYSTEMS FOR HEALTH: FINDING INTERVENTIONS THAT WORK. Public Health Nutrition.  9(8), 1013-1019, 2006.MEASUREMENT OF TOTAL VITAMIN B12 AND HOLOTRANSCOBALAMIN, SINGLY AND IN COBMINATION, IN SCREENING FOR METABOLIC VITAMIN B12 DEFICIENCY-() Miller, J.W., Garrod, M.G., Rockwood, A.L., Kushnir, M.M., Allen, L.H., Haan, M.N., Green, R. Measurement of total vitamin b12 and holotranscobalamin, singly and in cobmination, in screening for metabolic vitamin b12 deficiency. Clinical Chemistry. 52 (2): 278-85, 2006.INTERNATIONAL RESEARCH ON INFANT SUPPLEMENTATION STUDY: RANDOMIZED CONTROLLED TRIALS OF MICRONUTRIENT SUPPLEMENTATION DURING INFANCY-(Peer Reviewed Journal) Allen, L.H., Shrimpton, R. 2005. INTERNATIONAL RESEARCH ON INFANT SUPPLEMENTATION STUDY: IMPLICATIONS FOR PROGRAMS AND FURTHER RESEARCH. Journal of Nutrition.  135:666S-669S.DIETARY GUIDELINES AND SAFE SUPPLEMENT USE-() Allen, L.H., Graham, J.M., Sabel, J.E. Dietary guidelines and safe supplement use. Encyclopedia of Human Nutrition. 2005 Elsevier Ltd. 8-16.LOW FOLATE STATUS IS ASSOCIATED WITH IMPAIRED COGNITIVE FUNCTION AND DEMENTIA IN THE SACRAMENTO AREA LATINO STUDY ON AGING-(Peer Reviewed Journal) Ramos, M.I., Allen, L.H., Mungas, D.M., Jagust, W.J., Haan, M.N., Green, R., Miller, J.W. 2005. LOW FOLATE STATUS IS ASSOCIATED WITH IMPAIRED COGNITIVE FUNCTION AND DEMENTIA IN THE SACRAMENTO AREA LATINO STUDY ON AGING. American Journal of Clinical Nutrition.  82:1346-1352, 2005.CALCIUM-() Allen, L.H., Kerstetter, J.E. Calcium. Encyclopedia of Human Nutrition. 2005, Elsevier Ltd. 253-259.ERYTHROCYTE RIBOFLAVIN FOR THE DETECTION OF RIBOFLAVIN DEFICIENCY IN PREGNANT NEPALI WOMEN-(Peer Reviewed Journal) Graham, J.M., Peerson, J.M., Haskell, M.J., Shrestha, R.K., Brown, K.H., Allen, L.H. 2005. ERYTHROCYTE RIBOFLAVIN FOR THE DETECTION OF RIBOFLAVIN DEFICIENCY IN PREGNANT NEPALI WOMEN. Clinical Chemistry. 51:2162-2165, 2005.LOW ERYTHROCYTE FOLATE, BUT NOT PLASMA VITAMIN B-12 OR HOMOCYSTEINE, IS ASSOCIATED WITH DEMENTIA IN ELDERLY LATINOS-(Peer Reviewed Journal) Campbell, A.K., Jagust, W.J., Mungas, D.M., Miller, J.W., Green, R., Haan, M.N., Allen, L.H. 2005. LOW ERYTHROCYTE FOLATE, BUT NOT PLASMA VITAMIN B-12 OR HOMOCYSTEINE, IS ASSOCIATED WITH DEMENTIA IN ELDERLY LATINOS. Journal of Nutrition Health and Aging.  9(1):39-43.VITAMIN B-12-() Allen, L.H., Jones, K.M. Vitamin B-12. Encyclopedia of Dietary Supplements. 2005. ISBN:0-8247-5504-9;112-121.NUTRITION KNOWLEDGE AND PRACTICES, AND CONSUMPTION OF VITAMIN A-RICH PLANTS BY RURAL NEPALI PARTICIPANTS AND NONPARTICIPANTS IN A KITCHEN-GARDEN PROGRAM-() Jones, K.M., Specio, S.E., Shrestha, P., Brown, K.H., Allen, L.H. 2005. NUTRITION KNOWLEDGE AND PRACTICES, AND PRODUCTION OF PLANT SOURCES OF VITAMIN A, IN RURAL NEPALI PARTICIPANTS AND NON-PARTICIPANTS IN AN AGRICULTURAL DEVELOPMENT PROJECT. Food and Nutrition Bulletin. Vol. 26, No. 2.MULTIPLE MICRONUTRIENTS IN PREGNANCY AND LACTATION: AN OVERVIEW-(Peer Reviewed Journal) Allen, L.H. 2005. MULTIPLE MICRONUTRIENTS IN PREGNANCY AND LACTATION: AN OVERVIEW. American Journal of Clinical Nutrition.  81(suppl):1206S-12S, 2005.PULQUE INTAKE DURING PREGNANCY AND LACTATION IN RURAL MEXICO: ALCOHOL AND CHILD GROWTH FROM 1 TO 57 MONTHS-(Peer Reviewed Journal) Backstrand, J.R., Goodman, A.H., Allen, L.H., Pelto, G.H. 2004. PULQUE INTAKE DURING PREGNANCY AND LACTATION IN RURAL MEXICO: ALCOHOL AND CHILD GROWTH FROM 1 TO 57 MONTHS. European Journal of Clinical Nutrition.  58(12):1626-34, 2004.WEIGHT GAIN-() Allen, L.H., Graham, J.M. Weight gain. Encyclopedia of Human Nutrition; Pregnancy/Weight Gain, Elsevier Ltd. 2005:533-538.FOLATE AND VITAMIN B-12 STATUS IN THE AMERICAS-() Allen, L.H. 2004. FOLATE AND VITAMIN B-12 STATUS IN THE AMERICAS. Nutrition Reviews. Vol. 62, No. 6.Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification-(Peer Reviewed Journal) Ramos, M.I., Allen, L.H., Haan, M.N., Green, R., Miller, J.W. 2004. Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification. American Journal of Clinical Nutrition. 80:1024-1028.
 Prominent ProjectsField Study-MRC The Gambia: Mothers, Infants and Lactation Quality (MILQ) ProjectCooperative Agreement (A)Accession Number:431511Field Study-Bangladesh: Mothers, Infants and Lactation Quality(MILQ) ProjectCooperative Agreement (A)Accession Number:432151Field Study - Copenhagen: the Mothers, Infants and Lactation Quality (MILQ) ProjectCooperative Agreement (A)Accession Number:432295Field Study-Rio de Janeiro: Mothers, Infants and Lactation Quality (MILQ) ProjectCooperative Agreement (A)Accession Number:432312Maternal, Infant, and Human Milk Iodine Status in the MILQ StudyCooperative Agreement (A)Accession Number:436499Improving Public Health by Understanding Metabolic and Bio-Behavioral Effects of Following Recommendations in the Dietary Guidelines for AmericansIn-House Appropriated (D)Accession Number:436165ELICIT: Early Life Interventions for Childhood Growth and Development In TanzaniaReimbursable Cooperative Agreement (R)Accession Number:434327Collaborative Research in Human NutritionNon-Assistance Cooperative Agreement (S)Accession Number:433250Analytical Study and Method Development of Vitamin and Mineral Composition of Human MilkNon-Assistance Cooperative Agreement (S)Accession Number:432234The Mothers, Infants and Lactation Quality (MILQ) Project: A Multi-Center Collaborative StudyTrust Fund Cooperative Agreement (T)Accession Number:432056Mothers, Infants and Lactation Quality-Extra Analyses (MILQ II) ProjectTrust Fund Cooperative Agreement (T)Accession Number:436408
 Methods, Technique and Software
                              **Methods and Technique**
The Allen lab uses an array of methods and techniques for biomarker analyses:
Ultra Performance Liquid Chromatography – tandem Mass Spectrometry:
• Waters ACQUITY UPLC®I-CLASS coupled to ABSciex Triple Quad 4500
High Performance Liquid Chromatography – Diode Array Detector/Fluorescence Detector:
• Agilent 1200 LC-System
• Agilent 1260 Infinity LC-System
Inductively Coupled Plasma – Atomic Emission Spectroscopy:
• Varian Vista AX CCD Simultaneous ICP-AES System
Competitive Chemiluminescent enzyme immunoassay
• Siemens IMMULITE® bioanalyzer
• Roche Cobas® e411 bioanalyzer
• Roche Cobas Integra® 400 plus bioanalyzer
SpectraStarTM 2600XT neonatal analyzer (TBD)
Biomarkers analyzed in the Allen Lab:
• Fat- and water-soluble vitamins in human milk and plasma
• Macronutrients in human milk (fat, protein, carbohydrates; TBD)
• One-carbon metabolites (methyl-malonic acid, total homocysteine)
• Iron status biomarkers
• Inflammation biomarkers
• Selected metabolites (amino acids, biogenic amines, acylcarnitines, glycerophospholipids, sphingolipids) in human milk and plasma (TBD)


        
        
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            Last Modified:
5/24/2021

    

    
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