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                    U.S. DEPARTMENT OF AGRICULTURE
 Natural Products Utilization Research: Oxford, MS
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ARS Home Southeast Area Oxford, Mississippi Natural Products Utilization Research People & Locations







Kumudini M Meepagala
                        Natural Products Utilization Research

                        




                        
                        Research Chemist
                        Phone: (662) 915-1030
                        
                        
                        Fax: (662) 915-1035(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            ProjectsBiopesticide Discovery and Development
                                                    In-House Appropriated
                                                                    (D)Accession Number: 437528Biobased Pesticide Discovery and Product Optimization and Enhancement from Medicinal and Aromatic Crops
                                                    In-House Appropriated
                                                                    (D)Accession Number: 438514**Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)Mining Biosynthetic Gene Clusters of Pseudomonas vancouverensis Utilizing Whole Genome Sequencing
                                                        

- (Peer Reviewed Journal)Tamang, P., Upadhaya, A., Paudel, P., Meepagala, K.M., Cantrell, C.L. 2024. Mining Biosynthetic Gene Clusters of Pseudomonas vancouverensis Utilizing Whole Genome Sequencing. Microorganisms. 12(3),548. https://doi.org/10.3390/microorganisms12030548.Pantoea ananatis, a plant growth stimulating bacterium, and its metabolites isolated from Hydrocotyle umbellata (dollarweed)
                                                        

- (Peer Reviewed Journal)Meepagala, K.M., Anderson, C.M., Techen, N., Duke, S.O. 2024. Pantoea ananatis, a plant growth stimulating bacterium, and its metabolites isolated from Hydrocotyle umbellata (dollarweed). Plant Signaling and Behavior. 19:1. https://doi.org/10.1080/15592324.2024.2331894.Antifungal and Phytotoxic activities of isolated compounds from Helietta parvifolia stems
                                                        

- (Peer Reviewed Journal)Ribeiro, V., Bajsa Hirschel, J.N., Tamang, P., Meepagala, K.M., Duke, S. 2023. Antifungal and phytotoxic activities of isolated compounds from Helietta parvifolia stems. Molecules. 28(23):7930. https://doi.org/10.3390/molecules28237930.Synthesis, Herbicidal Activity, and Structure-Activity Relationships of O-Alkyl Analogues of Khellin and Visnagin
                                                        

- (Peer Reviewed Journal)Cantrell, C. L.; Travaini, M. L.; Bajsa-Hirschel, J.; Svendsen, L. D.; Reichley, A.; Sosa, G. M.; Kim, S. J.; Tamang, P.; Meepagala, K.; Duke, S. O.  Synthesis, Herbicidal Activity, and Structure-Activity Relationships of O-Alkyl Analogues of Khellin and Visnagin. J. Agric. Food Chem. 2023, 71, 40, 14593–14603; doi:10.1021/acs.jafc.3c03254.Larvicidal constituents from Poncirus trifoliata root extracts
                                                        

- (Peer Reviewed Journal)Meepagala, K.M., Estep III, A.S. 2023. Larvicidal constituents from Poncirus trifoliata root extracts. Journal of Medical Entomology. https://doi.org/10.1093/jme/tjad086.Antifungal activity of Poncirus trifoliata roots against Colletotrichum species
                                                        

- (Peer Reviewed Journal)Meepagala, K.M., Tamang, P. 2023. Antifungal activity of Poncirus trifoliata roots against Colletotrichum species. Agricultural Sciences. https://doi.org/10.4236/as.2023.143022.Characterization of toxicological and neurophysiological effects of natural product based chromenes to Fall Armyworm, Spodoptera frugiperda
                                                        

- (Peer Reviewed Journal)Mccomic, S.E., Meepagala, K.M., Swale, D. 2021. Characterization of toxicological and neurophysiological effects of natural product based chromenes to Fall Armyworm, Spodoptera frugiperda. Journal of Economic Entomology. https://doi.org/10.1093/jee/toab172.Microbial transformation of some simple isoquinoline and benzyl
isoquinoline alkaloids and molecular docking studies of the
metabolites
                                                        

- (Peer Reviewed Journal)El-Aasr, M., Eliwa, D., Albadry, M.A., Ibrahim, A.S., Kabbash, A., Meepagala, K.M., Khan, I.A., Ross, S.A., Khan, S.I. 2021. Microbial transformation of some simple isoquinoline and benzyl isoquinoline alkaloids and molecular docking studies of the metabolites. Phytochemistry. https://doi.org/10.1016/j.phytochem.2021.112828.In silico and in vitro studies of isolated constituents from Callistemon citrinus leaves: Anti-microbial potential and inhibition of iNOS activity
                                                        

- (Peer Reviewed Journal)Abdelmalek, E.M., Zulfiqar, F., Albadry, M.A., Khan, S.I., Meepagala, K.M., Ramadan, M.A., Darwish, F.M., Assaf, M.H., Ross, S.A. 2021. In silico and in vitro studies of isolated constituents from Callistemon citrinus leaves: Anti-microbial potential and inhibition of iNOS activity. Phytochemistry. 185. https://doi.org/10.1016/j.phytochem.2021.112745.Furanocoumarin with Phytotoxic Activity from the Leaves of Amyris elemifera (Rutaceae)
                                                        

- (Peer Reviewed Journal)Meepagala, K.M., Bracken, A.K., Fronczek, F.R., Johnson, R.D., Wedge, D.E., Duke, S.O. 2020. A novel furanocoumarin with phytotoxic activity from the leaves of Amyris elemifera (Rutaceae). Journal of Agricultural and Food Chemistry. https://www.doi.org/10.1021/acsomega.0c04778.Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a
                                                        

- (Peer Reviewed Journal)Eliwa, D., Albadry, M.A., Ibrahim, A.S., Kabbash, A., Meepagala, K.M., Khan, I.A., El-Aasr, M., Ross, S.A. 2020. Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a. Phytochemistry. https://doi.org/10.1016/j.phytochem.2020.112598.Sesquiterpene-a-amino acid quaternary ammonium hybrids from Stereum complicatum (Steraceae)
                                                        

- (Peer Reviewed Journal)Perera, W.H., Meepagala, K.M., Duke, S.O. 2020. Sesquiterpene-a-amino acid quaternary ammonium hybrids from Stereum complicatum (Steraceae). Biochemical Systematics and Ecology. 93,104176. https://doi.org/10.1016/j.bse.2020.104176.Sesquiterpenoids from culture of the fungus Stereum complicatum (Steraceae): Structural diversity, antifungal, and phytotoxic activities
                                                        

- (Peer Reviewed Journal)Perera, W.H., Meepagala, K.M., Wedge, D.E., Duke, S.O. 2020. Sesquiterpenoids from culture of the fungus Stereum complicatum (Steraceae): Structural diversity, antifungal, and phytotoxic activities. Phytochemistry Letters. 37:51-58. https://doi.org/10.1016/j.phytol.2020.03.012.A phytotoxic and antifungal metabolite (Pyrichalasin H) from a fungus infecting Brachiaria eruciformis (Signal Grass)
                                                        

- (Peer Reviewed Journal)Meepagala, K.M., Clausen, B., Johnson, R.D., Wedge, D.E., Duke, S.O. 2019. A phytotoxic and antifungal metabolite (Pyrichalasin H) from a fungus infecting Brachiaria eruciformis (Signal Grass). Journal of Agricultural Chemistry and Environment. 8(3):115-128. https://doi.org/10.4236/jacen.2019.83010.Bioassay-guided isolation and structure elucidation of fungicidal and herbicidal compounds from Ambrosia salsola (Asteraceae)
                                                        

- (Peer Reviewed Journal)Perera, W.H., Meepagala, K.M., Fronczek, F.R., Cook, D., Wedge, D.E., Duke, S.O. 2019. Bioassay-guided isolation and structure elucidation of fungicidal and herbicidal compounds from Ambrosia salsola (Asteraceae). Molecules. 24:1-12. https://doi.org/10.3390/molecules24050835.Antibacterial activity of constituents from Mangosteen (Garcinia mangostana) fruit pericarp against several channel catfish pathogens
                                                        

- (Peer Reviewed Journal)Meepagala, K.M., Schrader, K.K. Antibacterial activity of constituents from Mangosteen Garcinia mangostana fruit pericarp against several channel catfish pathogens. Journal of Aquatic Animal Health. 2018;30:179-184. https://doi.org/10.1002/aah.10021.Mosquitocidal activity of a naturally occurring isochroman and synthetic analogs from the plant pathogenic fungus, Diaporthe eres against Aedes aegypti (Diptera: Culicidae)
                                                        

- (Peer Reviewed Journal)Meepagala, K.M., Estep, A.S., Clausen, B.M., Becnel, J.J. 2018. Mosquitocidal activity of a naturally occurring isochroman and synthetic analogs from the plant pathogenic fungus, Diaporthe eres against Aedes aegypti (Diptera: Culicidae). Journal of Medical Entomology. 55(4):969–974. doi:10.1093/jme/tjy016.Khellin and visnagin, furanochromones from Ammi visnaga (L.) Lam., as potential bioherbicides
                                                        

- (Peer Reviewed Journal)Travaini, M.L., Sosa, G.M., Ceccarelli, E.A., Walter, H., Cantrell, C.L., Carrillo, N.J., Dayan, F.E., Meepagala, K.M., Duke, S.O. 2016. Khellin and visnagin, furanochromones from Amni visnaga (L.) Lam., as potential bioherbicides. Journal of Agricultural and Food Chemistry. 64:9475-9487.Mosquitocidal activity of extracts from Ammi visnaga (Apiaceae) seeds
                                                        

- (Peer Reviewed Journal)Meepagala, K.M., Estep, A.S., Becnel, J.J. 2016. Mosquitocidal activity of extracts from Ammi visnaga (Apiaceae) seeds. Journal of Agricultural Chemistry and Environment. 5:170-178.Larvicidal and adulticidal activity chroman and chromene analogues against susceptible and permethrin-resistant mosquito strains
                                                        

- (Peer Reviewed Journal)Meepagala, K.M., Estep, A.S., Becnel, J.J. 2016. Larvicidal and adulticidal activity chroman and chromene analogues against susceptible and permethrin-resistant mosquito strains. Journal of Agricultural and Food Chemistry. 64(24):4914-4920.Curvularin and dehydrocurvularin as phytotoxic constituents from curvularia intermedia infecting pandanus amaryllifolius
                                                        

- (Peer Reviewed Journal)Meepagala, K.M., Johnson, R.D., Duke, S.O. 2016. Curvularin and dehydrocurvularin as phytotoxic constituents from curvularia intermedia infecting pandanus amaryllifolius. Journal of Agricultural and Food Chemistry. 5:12-22.Phomalactone from a phytopathogenic fungus infecting Zinnia elegans (Asteraceae) leaves

- (Peer Reviewed Journal)Meepagala, K.M., Johnson, R.D., Techen, N., Wedge, D.E., Duke, S.O. 2015. Phomalactone from a phytopathogenic fungus infecting Zinnia elegans (Asteraceae) leaves. Journal of Chemical Ecology. 41:602-612.Antibacterial activity of acylglucinol derivatives against Flavobacterium columnare

- (Peer Reviewed Journal)Meepagala, K.M., Schrader, K. 2014. Antibacterial activity of acylglucinol derivatives against Flavobacterium columnare. Journal of Agricultural Chemistry and Environment. 3:89-95.Antibacterial  compounds from Rutaceae with activities against Flavobacterium columnare and Streptococcus iniae

- (Peer Reviewed Journal)Meepagala, K.M., Schrader, K., Burandt, C. 2013. Antibacterial  compounds from Rutaceae with activities against Flavobacterium columnare and Streptococcus iniae. Journal of Agricultural Chemistry and Environment. 2(4):90-100.Mosquito repellents based on a natural chromene analogue with longer duration of action than N,N-Diethyl-meta-toluamide (DEET)

- (Peer Reviewed Journal)Meepagala, K.M., Bernier, U.R., Burandt, C., Duke, S.O. 2013. Mosquito repellents based on a natural chromene analogue with longer duration of action than N,N-Diethyl-meta-toluamide (DEET). Journal of Agricultural and Food Chemistry. 61:9293-9297.Phytochemicals for pest management: current advances and future opportunities

- (Book / Chapter)Duke, S.O., Baerson, S.R., Cantrell, C.L., Wedge, D.E., Meepagala, K.M., Pan, Z., Rimando, A.M., Schrader, K., Tabanca, N., Owens, D.K., Dayan, F.E. 2013. Phytochemicals for pest management: current advances and future opportunities. Recent Advances in Phytochemistry. 43:71-94.Natural product based chromenes as a novel class of potential termiticide

- (Peer Reviewed Journal)Meepagala, K.M., Osbrink, W.L., Burandt, C., Lax, A.R., Duke, S.O. 2011. Natural product based chromenes as a novel class of potential termiticide. Pest Management Science. 67:1446-1450.New Class of Algicidal Compounds and Fungicidal Activities
Derived from a Chromene Amide of Amyris texana

- (Peer Reviewed Journal)Meepagala, K.M., Schrader, K., Burandt, C., Wedge, D.E., Duke, S.O. 2010. New class of algicidal compounds and fungicidal activities derived from a chromene amide of Amyris texana. Journal of Agricultural and Food Chemistry 17:(58)9476-9482.New class of algicidal compounds and fungicidal activities derived from a chromene amide of Amyris texana

- (Peer Reviewed Journal)Meepagala, K.M., Schrader, K., Burandt, C., Wedge, D.E., Duke, S.O. 2010. New class of algicidal compounds and fungicidal activities derived from a chromene amide of Amyris texana. Journal of Agricultural and Food Chemistry. 58:9476-9482.Natural toxins for use in pest management

- (Peer Reviewed Journal)Duke, S.O., Cantrell, C.L., Meepagala, K.M., Wedge, D.E., Tabanca, N., Schrader, K. 2010. Natural toxins for use in pest management. Toxins. 2:1943-1962.Managing Earthworm Castings (Oligochaeta: Lumbricidae) in Turfgrass using a Natural By-Product of Tea Oil (Camellia sp.) Manufacture

- (Peer Reviewed Journal)Potter, D.A., Redmond, C.T., Meepagala, K.M., Williams, D.W. April 2010. Managing Earthworm Castings (Oligochaeta: Lumbricidae) in Turfgrass using a Natural By-Product of Tea Oil (Camellia sp.) Manufacture. Pest Management Science. 66(4), pp:439-446.Algicide Constituents from Swinglea glutinosa

- (Peer Reviewed Journal)Purcaro, R., Schrader, K., Burandt, C., Dellagreca, M., Meepagala, K.M. 2009. Algicide Constituents from Swinglea glutinosa. Journal of Agricultural and Food Chemistry. 57:10632-10635.DOD AFPMB and USDA ARS team up to develop new insecticides for mosquito control.

- (Peer Reviewed Journal)Hoel, D., Pridgeon, J.W., Bernier, U.R., Chauhan, K., Meepagala, K., Cantrell, C. 2010. Departments of Defense and Agriculture team up to develop new insecticides for mosquito control. Wing Beats. 21(1):29-34.The Case Against (-)-Catechin Involvement in Allelopathy in Centaurea stoebe (spotted knapweed)

- (Peer Reviewed Journal)Duke, S.O., Dayan, F.E., Bajsa, J.N., Meepagala, K.M., Hufbauer, R.A., Blair, A.C. 2009. The Case Against (-)-Catechin Involvement in Allelopathy in Centaurea stoebe (spotted knapweed). Plant Signaling and Behavior. 4(5):422-424.Is (-)-Catechin a "Novel Weapon" of Spotted Knapweed (Centaurea stoebe)?

- (Peer Reviewed Journal)Duke, S.O., Blair, A.C., Dayan, F.E., Johnson, R.D., Meepagala, K.M., Cook, D., Bajsa, J.N. 2009. Is (-)-Catechin a "Novel Weapon" of Spotted Knapweed (Centaurea stoebe)? Journal of Chemical Ecology. 35:141-153.Natural Products for Pest Management

- (Book / Chapter)Duke, S.O., Rimando, A.M., Schrader, K., Cantrell, C.L., Meepagala, K.M., Wedge, D.E., Tabanca, N., Dayan, F.E. 2008. Natural Products for Pest Management in Selected Topics of Natural Products. R. Ikan, ed., World Sci. Publishing Co., Singapore, pp. 209-251.Synthesis and structure-activity relationships of 1-undec-10-enoyl-piperidines as adulticides against the yellow fever mosquito Aedes aegypti (Diptera: Culicidae)

- (Abstract Only)Structure-Activity Relationships of 33 Piperidines as Adulticides against Aedes aegypti(Diptera: Culicidae)

- (Peer Reviewed Journal)Pridgeon, J.W., Meepagala, K.M., Becnel, J.J., Clark, G.G., Pereira, R.M., Linthicum, K. 2007. Structure-Activity Relationships of 33 Piperidines as Adulticides against Aedes aegypti(Diptera: Culicidae). Journal of Medical Entomology. 44(2):263-269.ALGICIDAL AND ANTIFUNGAL COMPOUNDS FROM THE ROOTS OF RUTA GRAVEOLENS AND SYNTHESIS OF THEIR ANALOGS

- (Peer Reviewed Journal)Meepagala, K.M., Schrader, K., Wedge, D.E., Duke, S.O. 2005. Algicidal and antifungal compounds from the roots of ruta graveolens and synthesis of their analogs. Phytochemistry. 66(22): 2689-2695.PLANT DERIVED NATURAL PRODUCTS EXHIBITING ACTIVITY AGAINST FORMOSAN SUBTERRANEAN TERMITES (COPTOTERMES FORMOSANUS)

- (Peer Reviewed Journal)Meepagala, K.M., Osbrink, W.L., Sturtz, G., Lax, A.R. 2006. Plant derived natural products exhibiting activity against formosan subterranean termites (coptotermes formosanus). Pest Management Science. 62:565-570.MOLLUSCICIDAL ACTIVITY OF VULGARONE B FROM ARTEMISIA DOUGLASIANA (BESSER) AGAINST THE INVASIVE, ALIEN, MOLLUSC PEST, POMACEA CANALICULATA (LAMARCK)

- (Peer Reviewed Journal)Joshi, R.C., Meepagala, K.M., Sturtz, G., Cagauan, A.G., Mendoza, C.O., Dayan, F.E., Duke, S.O. 2005. Molluscicidal activity of vulgarone b from artemisia douglasiana (besser) against the invasive, alien, mollusc pest, pomacea canaliculata (lamarck). International Journal of Pest Management. 51(3):175-180.PHYTOTOXIC AND ANTIFUNGAL COMPOUNDS FROM TWO APIACEAE SPECIES, LOMATIUM CALIFORNICUM AND LIGUSTICUM HULTENII, RICH SOURCES OF Z-LIGUSTILIDE AND APIOL, RESPECTIVELY.

- (Peer Reviewed Journal)Meepagala, K.M., Sturtz, G., Wedge, D.E., Schrader, K., Duke, S.O. 2005. Phytotoxic and antifungal compounds from two apiaceae species, lomatium californicum and ligusticum hultenii, rich sources of z-ligustilide and apiol, respectively.. Journal of Chemical Ecology. 31:1567-1578.PHYTOTOXINS FROM THE LEAVES OF RUTA GRAVEOLENS

- (Peer Reviewed Journal)Hale, A.L., Meepagala, K.M., Oliva, A., Aliotta, G., Duke, S.O. 2004. Phytotoxins from the leaves of ruta graveolens. Journal of Agricultural and Food Chemistry. 2004. V. 52(11). P. 3345-3349.ANTIMUTAGENIC ACTIVITY OF BERRY EXTRACTS

- (Peer Reviewed Journal)Smith, S.H., Tate, P.L., Huang, G., Magee, J.B., Meepagala, K.M., Wedge, D.E., Larcom, L.L. 2004. Antimutagenic activity of berry extracts. Journal of Medicinal Food. 7:450-455.MOLLUSCICIDAL ACTIVITY OF VULGARONE B AGAINST RAM'S HORN SNAIL

- (Peer Reviewed Journal)Meepagala, K.M., Sturtz, G., Mischke, C.C., Wise, D., Duke, S.O. 2004. Molluscicidal activity of vulgarone b against ram's horn snail. Pest Management Science. 60:479-482.VULGARONE B, THE ANTIFUNGAL CONSTITUENT IN THE STEAM-DISTILLED FRACTION OF ARTEMISIA DOUGLASIANA

- (Peer Reviewed Journal)MEEPAGALA, K.M., KUHAJEK, J.M., STURTZ, G.D., WEDGE, D.E. VULGARONE B, THE ANTIFUNGAL CONSTITUENT IN THE STEAM-DISTILLED FRACTION OF ARTEMISIA DOUGLASIANA. JOURNAL OF CHEMICAL ECOLOGY. 2003. v.29(8). p. 1771-1780.NATURAL FUNGICIDES FROM RUTA GRAVEOLENS L. LEAVES, INCLUDING A NEW QUINOLONE ALKALOID

- (Peer Reviewed Journal)OLIVA, A., MEEPAGALA, K.M., WEDGE, D.E., HARRIES, M.D., HALE, A.L., ALIOTTA, G., DUKE, S.O. 2003. NATURAL FUNGICIDES FROM RUTA GRAVEOLENS L. LEAVES, INCLUDING A NEW QUINOLONE ALKALOID. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 51(4):890-896.ANTIFUNGAL CONSTITUENTS OF ESSENTIAL OIL FRACTION OF ARTEMISIA DRACUNCULUS L. VAR. DRACUNCULUS

- (Peer Reviewed Journal)MEEPAGALA, K.M., STURTZ, G., WEDGE, D.E. ANTIFUNGAL CONSTITUENTS OF ESSENTIAL OIL FRACTION OF ARTEMISIA DRACUNCULUS L. VAR. DRACUNCULUS. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2002. v. 50(24). p. 6989-6992.MOLLUSCICIDAL AND ANTIFUNGAL ACTIVITY OF ERIGERON SPECIOSUS STEAM DISTILLATE

- (Peer Reviewed Journal)MEEPAGALA, K.M., STURTZ, G., WISE, D., WEDGE, D.E. MOLLUSCICIDAL AND ANTIFUNGAL ACTIVITY OF ERIGERON SPECIOSUS STEAM DISTILLATE. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2002. v. 58. p. 1043-1047.ANTICANCER ACTIVITY OF STRAWBERRY, BLUEBERRY AND RASPBERRY EXTRACTS TO     BREAST AND CERVICAL CANCER CELLS

- (Peer Reviewed Journal)


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