|   | 1. | I have reviewed this annual report on Form 10-Kof TG Therapeutics, Inc.; |
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|   | 2. | Based on my knowledge, this report does notcontain any untrue statement of a material fact or omit to state amaterial fact necessary to make the statements made, in light ofthe circumstances under which such statements were made, notmisleading with respect to the period covered by thisreport; |
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|   | 3. | Based on my knowledge, the consolidatedfinancial statements, and other financial information included inthis report, fairly present in all material respects the financialcondition, results of operations and cash flows of the registrantas of, and for, the periods presented in this report; |
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|   | 4. | The registrant’s other certifying officerand I are responsible for establishing and maintaining disclosurecontrols and procedures (as defined in Exchange Act Rules 13a-15(e)and 15d-15(e)) and internal control over financial reporting (asdefined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for theregistrant and have: |
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|   | a) | Designed such disclosure controls andprocedures, or caused such disclosure controls and procedures to bedesigned under our supervision, to ensure that material informationrelating to the registrant, including its consolidatedsubsidiaries, is made known to us by others within those entities,particularly during the period in which this report is beingprepared; |
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|   | b) | Designed such internal control over financialreporting, or caused such internal control over financial reportingto be designed under our supervision, to provide reasonableassurance regarding the reliability of financial reporting and thepreparation of financial statements for external purposes inaccordance with generally accepted accountingprinciples; |
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|   | c) | Evaluated the effectiveness of theregistrant’s disclosure controls and procedures and presentedin this report our conclusions about the effectiveness of thedisclosure controls and procedures, as of the end of the periodcovered by this report based on such evaluation; and |
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|   | d) | Disclosed in this report any change in theregistrant’s internal control over financial reporting thatoccurred during the registrant’s most recent fiscal quarter(the registrant’s fourth fiscal quarter in the case of anannual report) that has materially affected, or is reasonablylikely to materially affect, the registrant’s internalcontrol over financial reporting; and |
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|   | 5. | The registrant’s other certifying officerand I have disclosed, based on our most recent evaluation ofinternal control over financial reporting, to theregistrant’s auditors and the audit committee of theregistrant’s board of directors (or persons performing theequivalent functions): |
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|   | a) | All significant deficiencies and materialweaknesses in the design or operation of internal control overfinancial reporting which are reasonably likely to adversely affectthe registrant’s ability to record, process, summarize andreport financial information; and |
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|   | b) | Any fraud, whether or not material, thatinvolves management or other employees who have a significant rolein the registrant’s internal control over financialreporting. |
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| Date: March 21,2017 |                                                                                              | /s/ Michael S.Weiss |
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|                | Michael S.WeissExecutiveChairman, Chief Executive Officer and PresidentPrincipalExecutive Officer |