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ARS Home Southeast Area New Orleans, Louisiana Southern Regional Research Center Food and Feed Safety Research People & Locations







Perng Kuang  Chang

                                                                (PhD)
                        Food and Feed Safety Research

                        




                        
                        Molecular Biologist
                        Phone: (504) 286-4208
                        
                        
                        Fax: (504) 286-4419(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)
                            ProjectsAflatoxin Control through Identification of Intrinsic and Extrinsic Factors Governing the Aspergillus Flavus-Corn Interaction
                                                    In-House Appropriated
                                                                    (D)Accession Number: 440096**Publications**
                                                (Clicking on the reprint icon
                                                    Reprint Icon
                                                    will take you to the publication reprint.)Aspergillus flavus pangenome (AflaPan) uncovers novel aflatoxin and secondary metabolite associated gene clusters
                                                        

- (Peer Reviewed Journal)Gangurde, S., Korani, W., Bajaj, P., Wang, H., Fountain, J.C., Agarwal, G., Pandey, M.K., Abbas, H.K., Chang, P., Holbrook Jr, C.C., Kemerait, R.C., Varshney, R.K., Dutta, B., Pandey, M.K., Clevenger, J.P., Guo, B. 2024. Aspergillus flavus pangenome (AflaPan) uncovers novel aflatoxin and secondary metabolite associated gene clusters. BMC Plant Biology. 24:354. https://doi.org/10.1186/s12870-024-04950-8.Creating large chromosomal segment deletions in Aspergillus flavus by a dual CRISPR/Cas9 system: Deletion of gene clusters for production of aflatoxin, cyclopiazonic acid, and ustiloxin B
                                                        

- (Peer Reviewed Journal)Chang, P.-K. 2023. Creating large chromosomal segment deletions in Aspergillus flavus by a dual CRISPR/Cas9 system: Deletion of gene clusters for production of aflatoxin, cyclopiazonic acid, and ustiloxin B. Fungal Genetics and Biology. 170:103863. https://doi.org/10.1016/j.fgb.2023.103863.Are current Aspergillus sojae strains originated from native aflatoxigenic Aspergillus species population also present in California?
                                                        

- (Peer Reviewed Journal)Chang, P.-K., Sheng T. Hua, S. 2023. Are current Aspergillus sojae strains originated from native aflatoxigenic Aspergillus species population also present in California? Mycobiology. https://doi.org/10.1080/12298093.2023.2217495.Kojic acid gene clusters and the transcriptional activation mechanism of Aspergillus flavus KojR on expression of clustered genes
                                                        

- (Peer Reviewed Journal)Chang, P.-K., Scharfenstein, L.L., Mahoney, N., Kong, Q. 2023. Kojic acid gene clusters and the transcriptional activation mechanism of Aspergillus flavus KojR on expression of clustered genes. The Journal of Fungi. 9:259. https://doi.org/10.3390/jof9020259.A simple CRISPR/Cas9 system for efficiently targeting genes of Aspergillus section Flavi species, Aspergillus nidulans, Aspergillus fumigatus, Aspergillus terreus and Aspergillus niger
                                                        

- (Peer Reviewed Journal)Chang, P.-K. 2023. A simple CRISPR/Cas9 system for efficiently targeting genes of Aspergillus section Flavi species, Aspergillus nidulans, Aspergillus fumigatus, Aspergillus terreus and Aspergillus niger. Microbiology Spectrum. 11(1):1-18. https://doi.org/10.1128/spectrum.04648-22.Putative core transcription factors affecting virulence in Aspergillus flavus during infection of maize
                                                        

- (Peer Reviewed Journal)Gilbert, M.K., Mack, B.M., Lebar, M.D., Chang, P.-K., Gross, S.R., Sweany, R.R., Cary, J.W., Rajasekaran, K. 2023. Putative core transcription factors affecting virulence in Aspergillus flavus during infection of maize. The Journal of Fungi. 9(1):118. https://doi.org/10.3390/jof9010118.Aspergillus flavus pangenome to capture the diversity in a single reference genome

- (Abstract Only)Aspergillus flavus La3279, a component strain of the Aflasafe biocontrol product, contains a partial aflatoxin biosynthesis gene cluster followed by a genomic region highly variable among A. flavus isolates
                                                        

- (Peer Reviewed Journal)Chang, P. 2022. Aspergillus flavus La3279, a component strain of the Aflasafe biocontrol product, contains a partial aflatoxin biosynthesis gene cluster followed by a genomic region highly variable among A. flavus isolates. International Journal of Food Microbiology. 366:109559. https://doi.org/10.1016/j.ijfoodmicro.2022.109559.New insights of transcriptional regulator AflR in Aspergillus flavus physiology

- (Peer Reviewed Journal)Wang, P., Xu, J., Chang, P.-K., Liu, Z., Kong, Q. 2022. New insights of transcriptional regulator AflR in Aspergillus flavus physiology. Microbiology Spectrum. 10(1). Article e00791-21.Antifungal efficacy of redox-active natamycin against some foodborne fungi—comparison with Aspergillus fumigatus
                                                        

- (Peer Reviewed Journal)Kim, J., Tam, C.C., Chan, K.L., Cheng, L.W., Land, K.M., Friedman, M., Chang, P. 2021. Antifungal efficacy of redox-active natamycin against some foodborne fungi—comparison with Aspergillus fumigatus. Foods. 10(9). Article 2073. https://doi.org/10.3390/foods10092073.Authentication of Aspergillus parasiticus strains in the genome database of the National Center for Biotechnology Information
                                                        

- (Peer Reviewed Journal)Chang, P.-K. 2021. Authentication of Aspergillus parasiticus strains in the genome database of the National Center for Biotechnology Information. BMC Research Notes. 14:111. https://doi.org/10.1186/s13104-021-05527-6.Deciphering the origin of Aspergillus flavus NRRL21882, the active biocontrol agent of Afla-Guard®
                                                        

- (Peer Reviewed Journal)Chang, P.-K., Chang, T.D., Katoh, K. 2020. Deciphering the origin of Aspergillus flavus NRRL21882, the active biocontrol agent of Afla-Guard®. Letters in Applied Microbiology. 72:509-516. https://doi.org/10.1111/lam.13433.Two new Aspergillus flavus reference genomes reveal a large insertion potentially contributing to isolate stress tolerance and aflatoxin production
                                                        

- (Peer Reviewed Journal)Fountain, J.C., Clevenger, J.P., Nadon, B.D., Youngblood, R.C., Chang, P., Starr, D., Wang, H., Wiggins, R., Kemerait, R.C., Bhatnagar, D., Ozias-Akins, P., Varshney, R.K., Scheffler, B.E., Vaughn, J.N., Guo, B. 2020. Two new Aspergillus flavus reference genomes reveal a large insertion potentially contributing to isolate stress tolerance and aflatoxin production. Genes, Genomes, and Genomics. 10(9). https://doi.org/10.1534/g3.120.401405.Prevalence of NRRL21882-like (Afla-Guard®) Aspergillus flavus on sesame seeds grown in research fields in the Mississippi Delta
                                                        

- (Peer Reviewed Journal)Chang, P.-K., Scharfenstein, L.L., Abbas, H.K., Bellaloui, N., Accinelli, C., Ebelhar, M.W. 2020. Prevalence of NRRL21882-like (Afla-Guard®) Aspergillus flavus on sesame seeds grown in research fields in the Mississippi Delta. Biocontrol Science and Technology. 30:1090-1099. https://doi.org/10.1080/09583157.2020.1791798.Identification of AflR binding sites in the genome of Aspergillus flavus by ChIP-Seq
                                                        

- (Peer Reviewed Journal)Kong, Q., Chang, P.-K., Li, C., Hu, Z., Zheng, M., Sun, Q., Shan, S. 2020. Identification of AflR binding sites in the genome of Aspergillus flavus by ChIP-Seq. The Journal of Fungi. 6:52. https://doi.org/10.3390/jof6020052.Biosynthesis of conidial and sclerotial pigments in Aspergillus species
                                                        

- (Review Article)Chang, P.-K., Cary, J.W., Lebar, M.D. 2020. Biosynthesis of conidial and sclerotial pigments in Aspergillus species. Applied Microbiology and Biotechnology. 104:2277-2286. https://doi.org/10.1007/s00253-020-10347-y.Comparison of aflatoxin production of Aspergillus flavus at different temperatures and media: proteome analysis based on TMT
                                                        

- (Peer Reviewed Journal)Wang, P., Chang, P.-K., Kong, Q., Shan, S., Wei, Q. 2019. Comparison of aflatoxin production of Aspergillus flavus at different temperatures and media: proteome analysis based on TMT. International Journal of Food Microbiology. 310:108313. https://doi.org/10.1016/j.ijfoodmicro.2019.108313.Genome-wide nucleotide variation distinguishes Aspergillus flavus from Aspergillus oryzae and helps to reveal origins of atoxigenic A. flavus biocontrol strains
                                                        

- (Peer Reviewed Journal)Chang, P.-K. 2019. Genome-wide nucleotide variation distinguishes Aspergillus flavus from Aspergillus oryzae and helps to reveal origins of atoxigenic A. flavus biocontrol strains. Journal of Applied Microbiology. 127:1511-1520. https://doi.org/10.1111/jam.14419.Genome sequence of an Aspergillus flavus CA14 strain that is widely used in gene function studies
                                                        

- (Peer Reviewed Journal)Chang, P.-K., Scharfenstein, L.L., Mack, B.M., Hua, S.T. 2019. Genome sequence of an Aspergillus flavus CA14 strain that is widely used in gene function studies. Microbiology Resource Announcements. 8(33):e00837-19. https://doi.org/10.1128/MRA.00837-19.Identification of a copper-transporting ATPase involved in biosynthesis of A. flavus conidial pigment
                                                        

- (Peer Reviewed Journal)Chang, P.-K., Scharfenstein, L.L., Mack, B.M., Wei, Q., Gilbert, M.K., Lebar, M.D., Cary, J.W. 2019. Identification of a copper-transporting ATPase involved in biosynthesis of A. flavus conidial pigment. Applied Microbiology and Biotechnology. 103:4889-4897. https://doi.org/10.1007/s00253-019-09820-0.Transcriptional regulation of aflatoxin biosynthesis and conidiation in Aspergillus flavus by Wickerhamomyces anomalus WRL-076 for reduction of aflatoxin contamination
                                                        

- (Peer Reviewed Journal)Hua, S.T., Sarreal, S.L., Chang, P., Yu, J. 2019. Transcriptional regulation of aflatoxin biosynthesis and conidiation in Aspergillus flavus by Wickerhamomyces anomalus WRL-076 for reduction of aflatoxin contamination. Toxins. 11(2):81. https://doi.org/10.3390/toxins11020081.Monitoring metabolite production of aflatoxin biosynthesis by orbitrap fusion mass spectrometry and a D-optimal mixture design method
                                                        

- (Peer Reviewed Journal)Xie, H., Wang, X., Zhang, L., Wang, T., Zhang, W., Jiang, J., Chang, P.-K., Chen, Z.-Y., Bhatnagar, D., Zhang, Q., Li, P. 2018. Monitoring metabolite production of aflatoxin biosynthesis by orbitrap fusion mass spectrometry and a D-optimal mixture design method. Analytical Chemistry. 90:14331-14338. https://doi.org/10.1021/acs.analchem.8b03703.The transcriptional regulator Hbx1 affects the expression of thousands of genes in the aflatoxin-producing fungus Aspergillus flavus
                                                        

- (Peer Reviewed Journal)Cary, J.W., Entwistle, S., Satterlee, T., Mack, B.M., Gilbert, M.K., Chang, P.-K., Scharfenstein, L.L., Yin, Y., Calvo, A. 2019. The transcriptional regulator Hbx1 affects the expression of thousands of genes in the aflatoxin-producing fungus Aspergillus flavus. G3, Genes/Genomes/Genetics. 9(1):167-178. https://doi.org/10.1534/g3.118.200870.Aspergillus flavus GPI-anchored protein-encoding ecm33 has a role in growth, development, aflatoxin biosynthesis, and maize infection
                                                        

- (Peer Reviewed Journal)Chang, P.-K., Zhang, Q., Scharfenstein, L.L., Mack, B.M., Yoshimi, A., Miyazawa, K., Abe, K. 2018. Aspergillus flavus GPI-anchored protein-encoding ecm33 has a role in growth, development, aflatoxin biosynthesis, and maize infection. Applied Microbiology and Biotechnology. 102:5209-5220. https://doi.org/10.1007/s00253-018-9012-7.The Aspergillus flavus homeobox gene, hbx1, is required for development and aflatoxin production
                                                        

- (Peer Reviewed Journal)Cary, J.W., Harris-Coward, P.Y., Scharfenstein, L.L., Mack, B.M., Chang, P.-K., Wei, Q., Lebar, M.D., Carter-Wientjes, C.H., Majumdar, R., Mitra, C., Banerjee, S., Chanda, A. 2017. The Aspergillus flavus homeobox gene, hbx1, is required for development and aflatoxin production. Toxins. 9(10):315. https://doi.org/10.3390/toxins9100315.Aspergillus flavus aswA, a gene homolog of Aspergillus nidulans oefC, regulates sclerotial development and biosynthesis of sclerotium-associated secondary metabolites

- (Peer Reviewed Journal)Chang, P.-K., Scharfenstein, L.L., Li, R.W., Arroyo-Manzanares, N., De Saeger, S., Diana Di Mavungu, J. 2017. Aspergillus flavus aswA, a gene homolog of Aspergillus nidulans oefC, regulates sclerotial development and biosynthesis of sclerotium-associated secondary metabolites. Fungal Genetics and Biology. 104:29-37.Transcriptome of Aspergillus flavus aswA (AFLA_085170) deletion strain related to sclerotial development and production of secondary metabolites

- (Other)Chang, P.-K., Scharfenstein, L.L., Mack, B.M., Li, R.W. 2017. Transcriptome of Aspergillus flavus aswA (AFLA_085170) deletion strain related to sclerotial development and production of secondary metabolites. National Center for Biotechnology Information (NCBI). Accession: SRP082149.Cyclopiazonic acid is a pathogenicity factor for Aspergillus flavus and a promising target for screening germplasm for ear rot resistance

- (Peer Reviewed Journal)Chalivendra, S.C., DeRobertis, C., Chang, P.-K., Damann, K.E. 2017. Cyclopiazonic acid is a pathogenicity factor for Aspergillus flavus and a promising target for screening germplasm for ear rot resistance. Molecular Plant-Microbe Interactions. 30(5):361-373.The Aspergillus flavus fluP-associated metabolite promotes sclerotial production

- (Peer Reviewed Journal)Chang, P.-K., Scharfenstein, L.L., Ehrlich, K., Diana Di Mavungu, J. 2016. The Aspergillus flavus fluP-associated metabolite promotes sclerotial production. Fungal Biology. 120:1258-1268.Mycotoxins

- (Book / Chapter)Hua, S.T., Chang, P., Palumbo, J.D. 2017. Mycotoxins. In: Witczak, A., Sikorski, Z., editors. Toxins and Other Harmful Compounds in Foods. Boca Raton, FL: CRC Press. p. 153-168.Regulation of aflatoxin biosynthesis and branched-chain amino acids metabolism in Aspergillus flavus by 2-phenylethanol reveal biocontrol mechanism of Pichia anomala

- (Abstract Only)Hua, S.T., Chang, P., Beck, J.J., Li, R.W. 2016. Regulation of aflatoxin biosynthesis and branched-chain amino acids metabolism in Aspergillus flavus by 2-phenylethanol reveal biocontrol mechanism of Pichia anomala. Meeting Abstract. https://pag.confex.com/pag/xxiv/meetingapp.cgi/Paper/21990.Development of an enzyme-linked immunosorbent assay method specific for the detection of G-group aflatoxins

- (Peer Reviewed Journal)Li, P., Zhou, Q., Wang, T., Zhou, H., Zhang, W., Ding, X., Zhang, Z., Chang, P.-K., Zhang, Q. 2016. Development of an enzyme-linked immunosorbent assay method specific for the detection of G-group aflatoxins. Toxins. 8:5. doi: 10.3390/toxins8010005.The effect of 2-phenylethanol treatment on Aspergillus flavus transcriptome

- (Other)Chang, P-K., Hua, S.T., Sarreal, S.L., Scharfenstein, L.L., Li, R.W. 2015. The effect of 2-phenylethanol treatment on Aspergillus flavus transcriptome. National Center for Biotechnology Information (NCBI). Accession: SRP056528.High sequence variations in the region containing genes encoding a cellular morphogenesis protein and the repressor of sexual development help to reveal origins of Aspergillus oryzae
                                                        

- (Peer Reviewed Journal)Chang, P.-K., Scharfenstein, L.L., Solorzano, C.D., Abbas, H.K., Hua, S.-S. T., Jones, W.A., Zablotowicz, R.M. 2015. High sequence variations in the region containing genes encoding a cellular morphogenesis protein and the repressor of sexual development help to reveal origins of Aspergillus oryzae. International Journal of Food Microbiology. 200:66-71.High temperature, differentiation, and endoplasmic reticulum stress decrease but epigenetic and antioxidative agents increase Aspergillus ribosomal protein gene expression

- (Peer Reviewed Journal)Chang, P-K., Wang, B., He, Z-M., Yu, J., Pan, L. 2014. High temperature, differentiation, and endoplasmic reticulum stress decrease but epigenetic and antioxidative agents increase Aspergillus ribosomal protein gene expression. Austin Journal of Proteomics, Bioinformatics & Genomics. 1(1):6.Genetic variability of Aspergillus flavus isolates from a Mississippi corn field

- (Peer Reviewed Journal)Solorzano Torres, C.D., Abbas, H.K., Zablotowicz, R.M., Chang, P., Jones, W.A. 2014. Genetic variability of Aspergillus flavus isolates from a Mississippi corn field. The Scientific World. 2014: 8 pages.Aspergillus flavus Blast2GO gene ontology database: elevated growth temperature alters amino acid metabolism

- (Peer Reviewed Journal)Chang, P-K., Scharfenstein, L.L. 2014. Aspergillus flavus Blast2GO gene ontology database: elevated growth temperature alters amino acid metabolism. Journal of Genetics and Genome Research. 1:005.Lack of aflatoxin production by Aspergillus flavus on a resistant peanut line is associated with delayed expression of aflatoxin genes

- (Peer Reviewed Journal)Zhang, H., Scharfenstein, L.L., Carter Wientjes, C.H., Chang, P., Zhang, D., Meng, X., Yu, J. 2015. Lack of aflatoxin production by Aspergillus flavus on a resistant peanut line is associated with delayed expression of aflatoxin genes. World Mycotoxin Journal. 8(3):335-340.Global health issues of aflatoxins in food and agriculture: challenges and opportunities

- (Book / Chapter)Razzaghi-Abyaneh, M., Chang, P-K., Shams-Ghahfarokhi, M., Rai, M. 2014. Global health issues of aflatoxins in food and agriculture: challenges and opportunities. Frontiers in Microbiology. 5(420):5-7. DOI 10.3389/fmicb.2014-00420.Peanut resistant gene expression in response to Aspergillus flavus infection during seed germination

- (Peer Reviewed Journal)Zhang, H., Scharfenstein, L.L., Zhang, D., Chang, P., Montalbano, B.G., Guo, B., Meng, X., Yu, J. 2014. Peanut resistant gene expression in response to Aspergillus flavus infection during seed germination. Journal of Phytopathology. 163(3):212-221.Transcriptomic profiles of Aspergillus flavus CA42, a strain that produces small sclerotia, by decanal treatment and after recovery

- (Peer Reviewed Journal)Chang, P.-K., Scharfenstein, L.L., Mack, B.M., Yu, J., Ehrlich, K. 2014. Transcriptomic profiles of Aspergillus flavus CA42, a strain that produces small sclerotia, by decanal treatment and after recovery. Fungal Genetics and Biology. 68:39-47.Transcriptomic profiling of decanal effects on Aspergillus flavus gene expression in development and secondary metabolism

- (Other)Chang, P-K., Scharfenstein, L.L., Yu, J., Mack, B.M., Ehrlich, K.C., Losada, L., Nierman, W.C., Bhatnagar, D. 2014. Transcriptomic profiling of decanal effects on Aspergillus flavus gene expression in development and secondary metabolism. National Center for Biotechnology Information (NCBI). Accession: SRX471362.Aspergillus: introduction

- (Book / Chapter)Chang, P-K., Horn, B.W., Abe, K., Gomi, K. 2014. Aspergillus: introduction. In: Batt, C.A., Tortorello, M.L. (Eds.). Encyclopedia of Food Microbiology. Volume 1. Elsevier Ltd, Academic Press. p. 77-82.Aspergillus flavus VelB acts distinctly from VeA in conidiation and may coordinate with FluG to modulate sclerotial production

- (Peer Reviewed Journal)Chang, P-K., Scharfenstein, L.L., Li, P., Ehrlich, K. 2013. Aspergillus flavus VelB acts distinctly from VeA in conidiation and may coordinate with FluG to modulate sclerotial production. Fungal Genetics and Biology. 58-59:71-79.Genome-wide analysis of the Zn(II)2Cys6 zinc cluster-encoding gene family in Aspergillus flavus
                                                        

- (Peer Reviewed Journal)Chang, P.-K., Ehrlich, K. 2013. Genome-wide analysis of the Zn(II)2Cys6 zinc cluster-encoding gene family in Aspergillus flavus. Applied Microbiology and Biotechnology. 97(10):4289-4300.Aspergillus flavus genetic diversity of corn fields treated with non-toxigenic strain afla-guard in the southern U.S

- (Abstract Only)Enhancement of commercial antifungal agents by kojic acid

- (Peer Reviewed Journal)Kim, J.H., Chang, P., Chan, K.L., Faria, N.G., Mahoney, N.E., Kim, Y., Martins, M.L., Campbell, B.C. 2012. Enhancement of activity of commercial antifungal agents by kojic acid. International Journal of Molecular Sciences. 13:13867-13880.  DOI:10.3390/ijms131113867.Deletion of the Aspergillus flavus orthologue of A. nidulans fluG reduces conidiation and promotes production of sclerotia but does not abolish aflatoxin biosynthesis

- (Peer Reviewed Journal)Chang, P-K., Scharfenstein, L.L., Mack, B.M., Ehrlich, K. 2012. Deletion of the Aspergillus flavus orthologue of A. nidulans fluG reduces conidiation and promotes production of sclerotia but does not abolish aflatoxin biosynthesis. Applied and Environmental Microbiology. 78(21):7557-7563.Identification of genetic defects in the atoxigenic biocontrol strain Aspergillus flavus K49 reveals the presence of a competitive recombinant group in field populations

- (Peer Reviewed Journal)Chang, P.-K., Abbas, H.K., Weaver, M.A., Ehrlich, K., Scharfenstein, L.L., Cotty, P.J. 2012. Identification of genetic defects in the atoxigenic biocontrol strain Aspergillus flavus K49 reveals the presence of a competitive recombinant group in field populations. International Journal of Food Microbiology. 154:192-196.Effects of laeA deletion on Aspergillus flavus conidial development and hydrophobicity may contribute to loss of aflatoxin production

- (Peer Reviewed Journal)Chang, P.-K., Scharfenstein, L.L., Ehrlich, K., Wei, Q., Bhatnagar, D., Ingber, B.F. 2012. Effects of laeA deletion on Aspergillus flavus conidial development and hydrophobicity may contribute to loss of aflatoxin production. Fungal Biology. 116:298-307.Characterization of toxigenic and atoxigenic Aspergillus flavus isolates from pistachio

- (Peer Reviewed Journal)Hua, S.T., Mcalpin, C.E., Chang, P., Sarreal, S.L. 2012. Characterization of toxigenic and atoxigenic Aspergillus flavus isolates from pistachio. Mycotoxin Research. Vol 28:67-75.Cyclopiazonic acid biosynthesis by Aspergillus flavus

- (Peer Reviewed Journal)Chang, P.-K., Ehrlich, K. 2011. Cyclopiazonic acid biosynthesis by Aspergillus flavus. Toxin Reviews. 30:79-89.Aflatoxins: mechanisms of inhibition by antagonistic plants and microorganisms

- (Book / Chapter)Razzaghi-Abyaneh, M., Shams-Ghahfarokhi, M., Chang, P-K. 2011. Aflatoxins: mechanisms of inhibition by antagonistic plants and microorganisms. In: Guevara-Gonzalez, R.G., editor. Aflatoxins - Biochemistry and Molecular Biology. Rijeka, Croatia: Intech Open Access publishers. pp 285-304.Control of aflatoxin biosynthesis in Aspergilli

- (Book / Chapter)Ehrlich, K., Chang, P.-K., Yu, J., Cary, J.W., Bhatnagar, D. 2011. Control of aflatoxin biosynthesis in Aspergilli. In: Guevara-Gonzalez, R.G., editor. Aflatoxins - Biochemistry and Molecular Biology. Rijeka, Croatia: Intech Open Access Publishers. pp 21-40.Mycotoxins

- (Review Article)Ehrlich, K., Chang, P.-K., Bhatnagar, D. 2011. Mycotoxins. Encyclopedia of Life Sciences. John Wiley & Sons Ltd, Chichester. http://www.els.net [DOI:10.1002/9780470015902.a0000373.pub2].Loss of msnA, a putative stress regulatory gene, in Aspergillus parasiticus and Aspergillus flavus increased production of conidia, aflatoxins and kojic acid

- (Peer Reviewed Journal)Chang, P.-K., Scharfenstein, L.L., Luo, M., Mahoney, N.E., Molyneux, R.J., Yu, J., Brown, R.L., Campbell, B.C. 2011. Loss of msnA, a putative stress regulatory gene, in Aspergillus parasiticus and Aspergillus flavus increased production of conidia, aflatoxins and kojic acid. Toxins. 3:82-104.HypC, the anthrone oxidase involved in aflatoxin biosynthesis

- (Peer Reviewed Journal)Ehrlich, K., Li, P., Scharfenstein, L.L., Chang, P.-K. 2010. HypC, the anthrone oxidase involved in aflatoxin biosynthesis. Applied and Environmental Microbiology. 76(10):3374-3377.Development and refinement of a high-efficiency gene-targeting system for Aspergillus flavus

- (Peer Reviewed Journal)Chang, P.-K., Scharfenstein, L.L., Wei, Q., Bhatnagar, D. 2010. Development and refinement of a high-efficiency gene-targeting system for Aspergillus flavus. Journal of Microbiological Methods. 81:240-246.What Does Genetic Diversity of Aspergillus flavus Tell Us About Aspergillus oryzae?

- (Review Article)Chang, P-K., Ehrlich, K. 2010. What Does Genetic Diversity of Aspergillus flavus Tell Us About Aspergillus oryzae? International Journal of Food Microbiology. 138(3):189-199.Absence of the Aflatoxin Biosynthesis Gene, norA, allows accumulation of deoxyaflatoxin B1 in Aspergillus flavus cultures

- (Peer Reviewed Journal)Ehrlich, K., Chang, P., Scharfenstein, L.L., Cary, J.W., Crawford, J.M., Townsend, C.A. 2010. Absence of the Aflatoxin Biosynthesis Gene, norA, allows accumulation of deoxyaflatoxin B1 in Aspergillus flavus cultures. FEMS Microbiology Letters. 305:65-70.Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae

- (Review Article)Chang, P-K., Ehrlich, K., Fujii, I. 2009. Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae. Toxins. 1:74-99.Aflatoxin Biosynthesis and Sclerotial Development in Aspergillus flavus and Aspergillus parasiticus

- (Book / Chapter)Chang, P-K. 2010. Aflatoxin Biosynthesis and Sclerotial Development in Aspergillus flavus and Aspergillus parasiticus. In M. Rai and A. Varma (eds), Mycotoxins in Food, Feed and Bioweapons. Springer-Verlag Berlin Heidelberg. p 77-92.Influence of Gene Expression on Variable Aflatoxin Production by Different Strains of Aspergillus flavus

- (Abstract Only)Clustered Genes Involved in Cyclopiazonic Acid Production are Next to the Aflatoxin Biosynthesis Gene Cluster in Aspergillus flavus

- (Peer Reviewed Journal)Chang, P.-K., Horn, B.W., Dorner, J.W. 2009. Clustered Genes Involved in Cyclopiazonic Acid Production are Next to the Aflatoxin Biosynthesis Gene Cluster in Aspergillus flavus. Fungal Genetics and Biology. 46:176-182.Aspergillus parasiticus CrzA, Which Encodes a Calcineurin Response Zinc-Finger Protein, is Required for Aflatoxin Production Under Calcium Stress

- (Peer Reviewed Journal)Chang, P.-K. 2008. Aspergillus parasiticus crzA, Which Encodes Calcineurin Response Zinc-Finger Protein, Is Required for Aflatoxin Production under Calcium Stress. International Journal of Molecular Sciences. 9:2027-2043.Are the Genes nadA and norB Involved in Formation of Aflatoxin G1

- (Peer Reviewed Journal)Ehrlich, K., Scharfenstein, L.L., Montalbano, B.G., Chang, P. 2008. Are the Genes nadA and norB Involved in Formation of Aflatoxin G1. International Journal of Molecular Sciences. 9:1717-1729.Aflatoxins

- (Book / Chapter)Yu, J., Chang, P.-K., Cleveland, T.E., Bennett, J.W. 2010. Aflatoxins. In: Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, M.C. Flickinger, Editor. John Wiley & Sons, Inc.: Hoboken, New Jersey. pp. 1-12.A Highly Efficient Gene-Targeting System for Aspergillus parasiticus

- (Peer Reviewed Journal)Chang, P. 2008. A highly efficient gene-targeting system for aspergillus parasiticus. Letters in Applied Microbiology. 46:587-592.Genes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers

- (Abstract Only)Chang, P., Wilkinson, J.R., Horn, B.W., Yu, J., Bhatnagar, D., Cleveland, T.E. 2007. Genes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers. Multicrop Aflatoxin and Fumonisin Elimination and Fungal Genomics Workshop-The Peanut Foundation, Atlanta, GA. p. 34.Genes differentially expressed by Aspergillus flavus strains after loss of aflatoxin production by serial transfers

- (Peer Reviewed Journal)Chang, P., Wilkinson, J.R., Horn, B.W., Yu, J., Bhatnagar, D., Cleveland, T.E. 2007. Genes differentially expressed by Aspergillus flavus strains after loss of aflatoxin production by serial transfers. Applied Microbiology and Biotechnology. 77(4):917-925.Understanding Nonaflatoxigenicity of Aspergillus sojae: A Windfall of Aflatoxin Biosynthesis Research

- (Review Article)Chang, P.-K., Matsushima, K., Takahashi, T., Yu, J., Abe, K., Bhatnagar, D., Yuan, G., Koyama, Y., Cleveland, T.E. 2007. Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research. Applied Microbiology and Biotechnology. 76:977-984.Characterization of AFLAV, a Tfl/Sushi retrotransposon from Aspergillus flavus

- (Peer Reviewed Journal)Hua, S.T., Tarun, A.S., Pandey, S.N., Chang, L.Y., Chang, P. 2007. Characterization of AFLAV, a Tfl/Sushi retrotransposon from Aspergillus flavus. Mycopathologia. 163(2):97-104.Sequence Breakpoints in the Aflatoxin Biosynthesis Gene Cluster of Nonaflatoxigenic Aspergillus flavus Isolates

- (Abstract Only)Nonaflatoxigenic Aspergillus flavus TX9-8 Competitively Prevents Aflatoxin Production by A. flavus Isolates of Large and Small Sclerotial Morphotypes

- (Proceedings)Chang, P., Hua, S.T. 2007. Nonaflatoxigenic Aspergillus flavus TX9-8 competitively prevents aflatoxin production by A. flavus isolates of large and small sclerotial morphotypes. In: Proceedings of the 19th Annual Multi-Crop Aflatoxin Elimination Workshop, October 16-20, 2006, Fort Worth, Texas. p. 84.Molasses Supplementation Promotes Conidiation but Suppresses Aflatoxin Production by Small Sclerotial Aspergillus flavus

- (Peer Reviewed Journal)Chang, P.-K., Hua, S.T. 2007. Molasses Supplementation Promotes Conidiation but Suppresses Aflatoxin Production by Small Sclerotial Aspergillus flavus. Letters in Applied Microbiology. 44(2):131-137.Nonaflatoxigenic Aspergillus flavus TX9-8 Competitively Prevents Aflatoxin Accumulation by A. flavus Isolates of Large and Small Sclerotial Morphotypes

- (Peer Reviewed Journal)Chang, P.-K., Hua, S.S.T. 2007. Nonaflatoxigenic Aspergillus flavus TX9-8 Competitively Prevents Aflatoxin Accumulation by A. flavus Isolates of Large and Small Sclerotial Morphotypes. International Journal of Food Microbiology. 114:275-279.CLADAL RELATEDNESS AMONG ASPERGILLUS ORYZAE ISOLATES AND ASPERGILLUS FLAVUS S AND L MORPHOTYPE ISOLATES

- (Peer Reviewed Journal)Chang, P.-K., Ehrlich, K., Hua, S.T. 2006. Cladal relatedness among Aspergillus oryzae isolates and Aspergillus flavus S and L morphotype isolates. International Journal of Food Microbiology. 108:172-177.Sequence Breakpoints in the Aflatoxin Biosynthesis Gene Cluster and Flanking Regions in Nonaflatoxigenic Aspergillus flavus Isolates

- (Peer Reviewed Journal)Chang, P.-K., Horn, B.W., Dorner, J.W. 2005. Sequence Breakpoints in the Aflatoxin Biosynthesis Gene Cluster and Flanking Regions in Nonaflatoxigenic Aspergillus flavus Isolates. Fungal Genetics and Biology. 42(11):914-923.DETERMINATION OF CHROMOSOMAL BREAKPOINTS IN THE AFLATOXIN BIOSYNTHESIS GENE CLUSTER OF NONAFLATOXIGENIC ASPERGILLUS FLAVUS ISOLATES

- (Abstract Only)Chang, P.-K., Horn, B.W., Dorner, J.W. 2005. Determination of chromosomal breakpoints in the aflatoxin biosynthesis gene cluster of nonaflatoxigenic Aspergillus flavus isolates. XIthe International Congress of Mycology Proceedings and Abstracts. p. 10.CHARACTERIZATION OF DELETIONS IN THE AFLATOXIN BIOSYNTHETIC GENE CLUSTER OF NONAFLATOXIGENIC ASPERGILLUS FLAVUS ISOLATES

- (Abstract Only)Chang, P., Horn, B.W., Dorner, J.W. 2005. Characterization of deletions in the aflatoxin biosynthetic gene cluster of nonaflatoxigenic Aspergillus flavus isolates [abstract]. 105th General Meeting of the American Society for Microbiology, June 5-9, 2005, Atlanta, Georgia. p. 152.CHARACTERISTICS OF A RETROTRANSPOSON FROM ASPERGILLUS FLAVUS

- (Abstract Only)DELETIONS IN THE AFLATOXIN BIOSYNTHETIC GENE CLUSTER OF NONAFLATOXIGENIC AND CYCLOPIAZONIC ACID-NONPRODICING ASPERGILLUS FLAVUS ISOLATES

- (Abstract Only)Chang, P.-K., Horn, B.W., Dorner, J.W. 2005. Deletions in the aflatoxin biosynthetic gene cluster of nonaflatoxigenic and cyclopiazonic acid-nonprodicing Aspergillus flavus isolates. In: Proceedings of 2004 Multicrop Aflatoxin and Fumonisin Elimination and Fungal Genomics Workshop, October 25-28, 2004, Sacramento, CA. p. 79.CHARACTERIZATION OF THE ASPERGILLUS PARASITICUS DELTA 12-DESATURASE GENE: A ROLE FOR LIPID METABOLISM IN THE ASPERGILLUS-SEED INTERACTION

- (Peer Reviewed Journal)Wilson, R.A., Calvo, A.M., Chang, P.-K., Keller, N.P. 2004. Characterization of the Aspergillus parasiticus delta 12-desaturase gene: A role for lipid metabolism in the aspergillus-seed interaction. Microbiology. 150:2881-2888.AFLT, A MFS TRANSPORTER-ENCODING GENE LOCATED IN THE AFLATOXIN GENE CLUSTER, DOES NOT HAVE A SIGNIFICANT ROLE IN AFLATOXIN SECRETION

- (Peer Reviewed Journal)Chang, P.-K., Yu, J., Yu, J.-H. 2004. aflT, a MFS transporter-encoding gene located in the aflatoxin gene cluster, does not have a significant role in aflatoxin secretion. Fungal Genetics and Biology. 41:911-920.DELETION OF THE DELTA 12-OLEIC ACID DESATURASE GENE OF A NON-AFLATOXIGENIC ASPERGILLUS PARASITICUS FIELD ISOLATE AFFECTS CONIDIATION AND SCLEROTIAL DEVELOPMENT

- (Peer Reviewed Journal)Chang, P.-K., Wilson, R.A., Keller, N.P., Cleveland, T.E. 2004. Deletion of the delta 12-oleic acid desaturase gene of a non-aflatoxigenic Aspergillus parasiticus field isolate affects conidiation and sclerotial development. Journal of Applied Microbiology. 97:1178-1184.THE AFLATOXIN BIOSYNTHESIS CLUSTER GENE CYPA IS REQUIRED FOR AFLATOXIN G1 AND G2 FORMATION

- (Peer Reviewed Journal)Ehrlich, K.C., Chang, P.-K., Yu, J., Cotty, P.J. 2004. Aflatoxin biosynthesis cluster gene cypA is required for G aflatoxin formation. Applied and Environmental Microbiology. 70(11):6518-6524.Progress in Elucidating the Molecular Basis of the Host Plant-Aspergillus flavus Interaction: A Basis for Devising Strategies to Reduce Aflatoxin Contamination in Crops

- (Book / Chapter)Cleveland, T.E., Yu, J., Bhatnagar, D., Chen, Z.-Y., Brown, R.L., Chang, P.-K., Cary, J.W. 2005. Progress in Elucidating the Molecular Basis of the Host Plant-Aspergillus flavus Interaction: A Basis for Devising Strategies to Reduce Aflatoxin Contamination in Crops. In: Abbas, H.K., editor. Aflatoxin and Food Safety. Boca Raton, FL: Taylor & Francis. p. 167-193.CONVERSION OF VERSICONAL HEMIACETAL ACETATE TO VERSICONAL AND VERSICONOL ACETATE TO VERSICONOL BY ASPERGILLUS PARASITICUS ESTA-ENCODED ESTERASE DURING AFLATOXIN BIOSYNTHESIS

- (Abstract Only)Chang, P.-K., Yabe, K., Yu, J. 2004. Conversion of versiconal hemiacetal acetate to versiconal and versiconol acetate to versiconol by Aspergillus parasiticus estA-encoded esterase during aflatoxin biosynthesis [abstract]. Annual Meeting of American Society for Microbiology, New Orleans, Louisiana.TWO DELTA 9-STEARIC ACID DESATURASES ARE REQUIRED FOR ASPERGILLUS NIDULANS GROWTH AND DEVELOPMENT

- (Peer Reviewed Journal)Wilson, R.A., Chang, P.-K, Dobrzyn, A., Ntambi, J.M., Zarnowski, R., Keller, N.P. 2004. Two delta 9-stearic acid desaturases are required for Aspergillus nidulans growth and development. Fungal Genetics and Biology. 41:501-509.CLUSTERED PATHWAY GENES IN AFLATOXIN BIOSYNTHESIS

- (Peer Reviewed Journal)Yu, J., Chang, P.-K., Ehrlich, K., Cary, J.W., Bhatnagar, D., Cleveland, T.E., Payne, G.A., Linz, J.E., Woloshuk, C.P., Bennett, J.W. 2004. Clustered pathway genes in aflatoxin biosynthesis. Applied And Environmental Microbiology. 70(3):1253-1262.LACK OF INTERACTION BETWEEN AFLR AND AFLJ CONTRIBUTES TO NONAFLATOXIGENICITY OF ASPERGILLUS SOJAE

- (Peer Reviewed Journal)Chang, P.-K. 2004. Lack of interaction between AFLR and AFLJ contributes to nonaflatoxigenicity of Aspergillus sojae. Journal of Biotechnology. 107:245-253.Elucidation of the Molecular Basis of the Host Plant-Aspergillus flavus Interaction, a Basis for Devising Strategies to Reduce Aflatoxin Contamination in Crops

- (Review Article)Cleveland, T.E., Yu, J., Bhatnagar, D., Chen, Z.-Y., Brown, R.L., Chang, P.-K., Cary, J.W. 2004. Elucidation of the molecular basis of the host plant-Aspergillus flavus interaction, a basis for devising strategies to reduce aflatoxin contamination in crops. In: Shier, W.T., Tu, A.T., Yu, C., Abbas, H.K., editors. Journal of Toxicology - Toxin Reviews. New York, NY: Marcel Dekker, Inc. 23(2,3):345-380.CHARACTERIZATION OF THE COMPLETE AFLATOXIN PATHWAY GENE CLUSTER IN ASPERGILLUS PARASITICUS

- (Abstract Only)Yu, J., Chang, P.-K., Ehrlich, K., Cary, J.W., Bhatnagar, D., Cleveland, T.E. 2003. Characterization of the complete aflatoxin pathway gene cluster in Aspergillus parasiticus. Proceedings of USDA-ARS Aflatoxin/Fumonisin Elimination and Fungal Genomics Workshop, October 13-15, 2003, Savannah, Georgia.THE ASPERGILLUS PARASITICUS ESTA-ENCODED ESTERASE CONVERTS VERSICONAL HEMIACETAL ACETATE TO VERSICONAL AND VERSICONOL ACETATE TO VERSICONOL IN AFLATOXIN BIOSYNTHESIS

- (Peer Reviewed Journal)Chang, P.-K., Yabe, K., Yu, J. 2004. The Aspergillus parasiticus estA-encoded esterase converts versiconal hemiacetal acetate to versiconal and versiconol acetate to versiconol in Aflatoxin Biosynthesis. Applied and Environmental Microbiology. 70(6):3593-3599.ASPERGILLUS PARASITICUS AFLJ INTERACTS WITH AFLR AND REGULATES TRANSCRIPTION OF AFLATOXIN BIOSYNTHETIC PATHWAY GENES

- (Abstract Only)Chang, P. 2003. Aspergillus parasiticus aflj interacts with aflr and regulates transcription of aflatoxin biosynthetic pathway genes [abstract]. XXII Fungal Genetics Conference, March 13-18, 2003, Pacific Grove, Californa. p. 33.THE ASPERGILLUS PARASITICUS PROTEIN AFLJ INTERACTS WITH THE AFLATOXIN PATHWAY-SPECIFIC REGULATOR AFLR

- (Peer Reviewed Journal)Chang, P.-K. 2003. The Aspergillus parasiticus protein AFLJ interacts with the aflatoxin pathway-specific regulator AFLR. Molecular Genetics and Genomics. 268:711-719.METABOLIC PATHWAY REGULATION

- (Book / Chapter)Chang, P.-K., Todd, R.B. 2003. Metabolic pathway regulation. In: Arora, D.K., editor. Handbook of Fungal Biotechnology, Second Edition, Revised and Expanded. Marcel Dekker, Inc. p. 25-37.CLONING AND FUNCTIONAL EXPRESSION OF AN ESTERASE GENE IN ASPERGILLUS PARASITICUS

- (Peer Reviewed Journal)YU, J., CHANG, P., BHATNAGAR, D., CLEVELAND, T.E. CLONING AND FUNCTIONAL EXPRESSION OF AN ESTERASE GENE IN ASPERGILLUS PARASITICUS. MYCOPATHOLOGIA. 2003. V. 156(3). P. 227-234.THE AFLATOXIN BIOSYNTHETIC GENE ADHA IN ASPERGILLUS PARASITICUS IS         INVOLVED IN CONVERSION OF 5'-HYDROXYAVERANTIN TO AVERUFIN

- (Peer Reviewed Journal)CLONING OF SUGAR UTILIZATION PATHWAY GENE CLUSTER IN ASPERGILLUS           PARASITICUS

- (Peer Reviewed Journal)REPRESSOR-AFLR INTERACTION MODULATES AFLATOXIN BIOSYNTHESIS IN ASPERGILLUS PARASITICUS

- (Peer Reviewed Journal)CHARACTERIZATION OF THE ASPERGILLUS PARASITICUS MAJOR NITROGEN REGULATORY  GENE, AREA

- (Peer Reviewed Journal)GENERATION OF AFLR DISRUPTION MUTANTS OF ASPERGILLUS PARASITICUS

- (Peer Reviewed Journal)GENES ENCODING CYTOCHROME P450 AND MONOOXYGENASE ENZYMES DEFINE ONE END OF THE AFLATOXIN PATHWAY GENE CLUSTER IN ASPERGILLUS PARASITICUS

- (Peer Reviewed Journal)MYCOTOXINS IN AGRICULTURE

- (Review Article)THE CARBOXY-TERMINAL 23 AMINO ACID REGION OF ASPERGILLUS PARASITICUS AFLR  IS A TRANSCRIPTION ACTIVATION DOMAIN

- (Peer Reviewed Journal)


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