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ARS Home Pacific West Area Davis, California Western Human Nutrition Research Center Docs







Macrophage Studyheadline bar **Who is conducting the study?** Charles Stephensen, Ph.D. from the Western Human Nutrition Research Center (WHNRC) part of the United States Department of Agriculture (USDA) **What is the purpose of this study?** To perform in vitro experiments investigating the impact of diet-derived metabolites and gut-derived bacteria on the functional capacity of monocyte-derived macrophages (MDMs) derived from healthy human subjects **Where is the study being conducted?** WHNRC, 430 West Health Sciences Drive, University of California, Davis, California, 95616 **Who can participate in this study?** All healthy adults between the ages of 18-49 with a BMI of 18.5 – 39.9 kg/m2 **What would exclude me from participating in the study?** You are pregnant or breastfeeding.
You weigh less than 110lbs
You are unable to fast for 10-12 hours
You have anemia or other blood abnormalities based on a screening blood draw
You have HIV/AIDS or another disease that affects the immune system
You are participating in another research study **What can I expect to happen during the study?** First, you will be screened for eligibility with a short 15-minute telephone interview Second, if you meet our basic inclusion criteria, you will come to the WHNRC fasted for a screening visit so we can fully explain the study to you, get your consent to participate, and conduct a more in-depth assessment of your eligibility. This assessment will include a measurement of your height and weight and a vein assessment to ensure you have suitable veins for the blood draws. A licensed phlebotomist will draw 5ml of blood for a CBC with differential. Once we review the results of this test, we will determine your eligibility for enrollment. If you are determined to be eligible, you will be enrolled in the study. The study consists of monthly visits to the WHNRC for a year. Before each visit, we will ask you to fast overnight for 12 hours (i.e. 8 pm to 8 am). You may continue drinking water during the fast and is encouraged to maintain adequate hydration for the blood draws. During the visit, a licensed phlebotomist will draw one hundred twenty (120) mL of blood in twelve 10 ml sodium-EDTA tubes by venous puncture in the morning. At months 4, 8, and 12 an additional 5 mL of blood will be collected for a CBC with differential. **What is your compensation from this study?** You will receive $20 for each monthly blood draw up to a maximum of $240 for all 12 blood draws. If you are unable to complete the study, you will be compensated for the total number of blood draws you completed. Your total monthly compensation will be provided after 6 and 12 months of participation. **What should I do if I have questions or want to participate in the study?** Please contact our study line at 530-752-5177, press #4, and leave a message that you are interested in the vaccine study. One of our study team members will contact you to let you know more about the study and answer questions.


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