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ARS Home Pacific West Area Davis, California Western Human Nutrition Research Center Obesity and Metabolism Research People Nancy Keim





Keim Labheadline bar **KEIM LAB** /ARSUserFiles/2966/Keim Lab 1.JPG Research Scientist
                              **Nancy Keim, Ph.D.**
Research Leader
Adjunct Professor, UC Davis Department of Nutrition
Office: (530) 752-4163
Email address: nancy.keim@usda.gov
Google Scholar page
**Research Interests**
Research interests revolve around understanding the relationships between the foods we eat, metabolic health, and body weight. Current areas of investigation include evaluating the benefits of consuming important foods such as whole grains or dairy products on energy expenditure, substrate oxidation, satiety and chronic disease risk factors; determining optimal sources and amounts of different types of dietary carbohydrates that contribute to satiety, healthy eating behaviors, and reduce risk of chronic disease; and evaluating benefits of an active lifestyle in terms of preventing obesity and related chronic diseases.
**Keim Lab Themes**
Answers to the question of why some people lose more weight than others when dieting despite similar calorie intakes have been elusive. In collaboration with colleagues at the WHNRC, Dr. Keim identified critical factors associated with inter-individual variability in weight loss in response to controlled interventions. Following up on work done early in her career at ARS, where she identified associations between body fat loss, use of fat as preferred fuel, and exercise-induced lipolysis, Dr. Keim discovered more recently that body weight loss during a food-controlled trial was linked to executive function skills: participants with the best decision-making skills lost the most weight. A more in-depth analysis of clinical and metabolic determinants of weight loss demonstrated that physical activity levels, fat-burning capacity and metabolites indicative of mitochondrial oxidation were important variables associated with magnitude of weight change.
Considering the current obesity epidemic, it is of vital importance to understand how exercise impacts energy balance and metabolic health. Dr. Keim demonstrated that regular aerobic exercise did not consistently affect energy intake of moderately overweight women, contrary to conventional thinking. Instead, previously-learned eating behavior, based on the cognitive restraint construct, played a major role in determining energy intake and food choice. In a recent study, Dr. Keim found that regular physical activity prevented the accretion of android fat ("visceral" fat around the internal organs, typically associated with metabolic disease), and attenuated the drop in insulin sensitivity that is common in peri-menopausal women, providing the first evidence of these effects in a sub-population that is vulnerable to weight gain and the accompanying metabolic disturbances.
Restrained eating is a behavioral construct defined as a conscious effort to restrict food intake to reduce body weight or avoid weight gain. Dr. Keim used this construct to demonstrate that restrained eaters have different metabolic and physiologic responses to dietary interventions including increased insulin sensitivity, preferential use of carbohydrate for energy following standard mixed meals, and blunted satiety signals in response to food consumption when compared to unrestrained eaters. These distinct metabolic responses of restrained eaters may thwart their dietary efforts aimed at reducing weight and maintaining control of food intake.
Leptin is a fat cell-derived hormone critical to regulation of food intake (dampening) and energy expenditure (maintaining).Provided the first evidence in humans that leptin influences hunger during conditions of calorie restriction: during a long-term energy restriction, women who reported feeling most hungry had the largest relative decrease in circulating leptin levels.
One proposed barrier to healthy eating in low-income populations is the cost of nutrient-rich foods compared to energy-dense but nutrient-poor foods (i.e., "fast foods"). In collaboration with scientists at Univ. of Washington and Univ. of California Davis, found that the cost of diets of low-income women was higher for those women who chose diets of lower energy density and higher nutrient density. Further, the women who consumed a greater variety of vegetables on a weekly basis, a recommendation of the Dietary Guidelines, had better quality diets, but the cost of the diets was higher.
The health impacts of dietary sugar and, in particular, fructose and high fructose corn syrup have been widely-debated. Dr. Keim has been a long-standing member of a NIH-funded collaborative multi-disciplinary team who demonstrated that consumption of large amounts of beverages sweetened with fructose leads to metabolic dysfunctions including elevations in circulating triglycerides and LDL-cholesterol, stimulation of hepatic synthesis of lipids, accumulation of abdominal fat, and decreases in insulin sensitivity-all symptomatic of metabolic syndrome. Consumption of high levels of fructose also depressed metabolic rate and fat-burning for energy, which would substantially contribute to undesirable gain of weight and body fat with prolonged use.
    Research Team
    Selected Publications(Clicking on the reprint iconReprint Icon  will take you to the publication reprint.)Association of lactase persistence genotypes (rs4988235) and ethnicity with dairy intake in a healthy U.S. population-(Peer Reviewed Journal) Chin, E.L., Huang, L., Bouzid, Y.Y., Kirschke, C.P., Durbin-Johnson, B., Baldiviez, L.M., Bonnel, E.L., Keim, N.L., Korf, I., Stephensen, C.B., Lemay, D.G. 2019. Association of lactase persistence genotypes (rs4988235) and ethnicity with dairy intake in a healthy U.S. population. Nutrients.  https://doi.org/10.3390/nu11081860.Effects of fructose or glucose on circulating apoCIII and triglyceride and cholesterol content of lipoprotein subfractions in humans-(Peer Reviewed Journal) Hieronimus, B., Griffen, S.C., Keim, N.L., Bremer, A.A., Berglund, L., Nakajima, K., Havel, P.J., Stanhope, K. 2019. Effects of fructose or glucose on circulating apoCIII and triglyceride and cholesterol content of lipoprotein subfractions in humans. Journal of Clinical Medicine. 8(7):913. https://doi.org/10.3390/jcm8070913.The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part II: Results-() Riley, H.L., Kable, M.E., Marco, M.L., Keim, N.L. 2019. The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part II: Results. Advances in Nutrition. https://doi.org/10.1093/advances/nmz049.The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part I: Overview of Current Methods-() Hughes, R.L., Marco, M., Hughes, J.P., Keim, N.L., Kable, M.E. 2019. The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part I: Overview of Current Methods. Advances in Nutrition. https://doi.org/10.1093/advances/nmz022.Weight loss and fitness intervention increases markers of hepatic bile acid (BA) synthesis, while reducing serum total BA concentrations in sedentary, obese insulin resistant women-(Abstract Only)Diet quality for sodium and vegetables mediate effects of whole food diets on 8-week changes in stress load-(Peer Reviewed Journal) Soltani, H., Keim, N.L., Laugero, K.D. 2018. Diet quality for sodium and vegetables mediate effects of whole food diets on 8-week changes in stress load. Nutrients. 10(11):1606. https://doi.org/10.3390/nu10111606.Structural equation modeling of food craving across the menstrual cycle using behavioral, neuroendocrine, and metabolic factors-(Peer Reviewed Journal) Krishnan, S., Tryon, R.R., Agrawal, K., Welch, L.C., Horn, W.F., Newman, J.W., Keim, N.L. 2018. Structural equation modeling of food craving across the menstrual cycle using behavioral, neuroendocrine, and metabolic factors. Physiology and Behavior. 195:28-36. https://doi.org/10.1016/j.physbeh.2018.07.011.Impact of an 8-week controlled feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indices-(Peer Reviewed Journal) Krishnan, S., Adams, S.H., Allen, L.H., Laugero, K.D., Newman, J.W., Stephensen, C.B., Burnett, D.J., Witbracht, M.G., Welch, L.C., Que, E.S., Keim, N.L. 2018. Impact of an 8-week controlled feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indices. American Journal of Clinical Nutrition. 108(2):266-278. https://doi.org/10.1093/ajcn/nqy113.Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII and ApoE in humans consuming high fructose corn syrup-sweetened beverage-(Peer Reviewed Journal) Price, C.A., Argueta, D.A., Medici, V., Bremer, A.A., Lee, V., Nunez, M.V., Chen, G.X., Keim, N.L., Havel, P.J., Stanhope, K.L., Dipatrizio, N.V. 2018. Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII and ApoE in humans consuming high fructose corn syrup-sweetened beverage. American Journal of Physiology - Endocrinology and Metabolism. 315(2):E141-E149. https://doi.org/10.1152/ajpendo.00406.2017.A clear difference emerges in hormone patterns following a standard mid-day meal in regular breakfast eating or breakfast skipping young women-(Peer Reviewed Journal) Forester, S.M., Widaman, A.M., Krishnan, S., Witbracht, M.G., Horn, W.F., Laugero, K.D., Keim, N.L. 2018. A clear difference emerges in hormone patterns following a standard mid-day meal in regular breakfast eating or breakfast skipping young women. Journal of Nutrition. 148(5):658-692. https://doi.org/10.1093/jn/nxy020.Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults-(Peer Reviewed Journal) Baldiviez, L.M., Keim, N.L., Laugero, K.D., Hwang, D.H., Huang, L., Woodhouse, L.R., Burnett, D.J., Zerofsky, M., Bonnel, E., Allen, L.H., Newman, J.W., Stephensen, C.B. 2017. Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults. Biomed Central (BMC) Nutrition. 3(79):1-13. https://doi.org/10.1186/s40795-017-0197-4.Increased cytokine production by monocytes from human subjects who consumed grape powder was not mediated by differences in dietary intake patterns-(Peer Reviewed Journal) Zunino, S.J., Keim, N.L., Kelley, D.S., Bonnel, E.L., Souza, E.C., Peerson, J.M. 2017. Increased cytokine production by monocytes from human subjects who consumed grape powder was not mediated by differences in dietary intake patterns. Nutrition Research. 40:32-39.A potential tool for clinicians; evaluating a computer-led dietary assessment method in overweight and obese women during weight loss-(Peer Reviewed Journal) Widaman, A., Keim, N.L., Burnett, D.D., Miller, B., Witbract, M.G., Widaman, K.F., Laugero, K.D. 2017. A potential tool for clinicians; evaluating a computer-led dietary assessment method in overweight and obese women during weight loss. Nutrients. doi: 10.3390:nu9030218.The effects of moderate whole grain consumption on fasting glucose and lipids, gastrointestinal symptoms, and microbiota-(Peer Reviewed Journal) Cooper, D.N., Kable, M.E., Marco, M.L., De Leon, A., Rust, B.M., Baker, J.E., Horn, W.F., Burnett, D., Keim, N.L. 2017. The effects of moderate whole grain consumption on fasting glucose and lipids, gastrointestinal symptoms, and microbiota. Nutrients. 9(2):173. doi: 10.3390/nu9020173.The reinforcing value of vegetables does not increase with repeated exposure during a randomized controlled provided vegetable intervention among overweight and obese adults-(Abstract Only) Jahns, L.A., Johnson, L.K., Temple, J., Keim, N.L., Casperson, S.L., Roemmich, J.N. 2017. The reinforcing value of vegetables does not increase with repeated exposure during a randomized controlled provided vegetable intervention among overweight and obese adults [abstract]. Journal of Federation of American Societies for Experimental Biology. 31:794.4.Substitution or addition? How overweight and obese adults incorporate vegetables into their diet during a randomized controlled vegetable feeding trial-(Abstract Only) Jahns, L.A., Conrad, Z.S., Johnson, L.K., Temple, J., Keim, N.L., Roemmich, J.N. 2017. Substitution or addition? How overweight and obese adults incorporate vegetables into their diet during a randomized controlled vegetable feeding trial [abstract]. Journal of Federation of American Societies for Experimental Biology. 31:794.9.Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons-(Peer Reviewed Journal) Zhang, J., Light, A.R., Hoppel, C.L., Campbell, C., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Hughen, R.W., Keim, N.L., Newman, J.W., Hunter, G.R., Fernandez, J.R., Garvey, W.T., Harper, M., Fiehn, O., Adams, S.H. 2017. Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons. Experimental Physiology. 102(1):48-69. doi:10.1113/EP086019.Estradiol, SHBG and leptin interplay with food craving and intake across the menstrual cycle-(Peer Reviewed Journal) Krishnan, S., Tyron, R.R., Horn, W.F., Welch, L., Keim, N.L. 2016. Estradiol, SHBG and leptin interplay with food craving and intake across the menstrual cycle. Physiology and Behavior. 165:304-312. doi: 10.1016/j.physbeh.2016.08.010.The value of anthropometric indices for identifying women with features of metabolic syndrome-(Abstract Only) Welch, L.C., Horn, W.F., Krishnan, S., Kishimura, K.M., Que, E.S., Holguin, E., Keim, N.L. 2016. The value of anthropometric indices for identifying women with features of metabolic syndrome. Meeting Abstract.  Experimental Biology 2016, San Diego, CA, April 2-6, 2016..Bile Acid Responses in Methane and Non-Methane Producers to Standard Breakfast Meals-(Abstract Only) Rust, B., La Frano, M., Newman, J.W., Agrawal, K., Horn, W.F., Welch, L., Marco, M., Martin, R., Keim, N.L. 2016. Bile Acid Responses in Methane and Non-Methane Producers to Standard Breakfast Meals. Meeting Abstract. Experimental Biology 2016, San Diego, CA April 2-6, 2016.Menstrual cycle hormones, food intake, and cravings-(Abstract Only) Krishnan, S., Tyron, R., Welch, L., Horn, W.F., Keim, N.L. 2016. Menstrual cycle hormones, food intake, and cravings. Meeting Abstract.  Experimental Biology 2016, April 2-6, 2016, San Diego, CA.Dietary Adherence Monitoring Tool for Free-living, Controlled Feeding Studies-(Abstract Only) Burnett, D.J., Peerson, J.M., Miller, B., Welch, L.C., Witbract, M.G., Krishnan, S., Keim, N.L. 2016. Dietary Adherence Monitoring Tool for Free-living, Controlled Feeding Studies. Meeting Abstract. Experimental Biology 2016, San Diego, CA April 2-6, 2016.Comparison of the Effects of a Sweetened Beverage Intervention on Self-Selected Food Intake-(Abstract Only) Widaman, A.M., Stanhope, K.L., Chen, G.X., Medici, V., Bremer, A.A., Lee, V., Nunez, M.V., Havel, P.J., Keim, N.L. 2016. Comparison of the Effects of a Sweetened Beverage Intervention on Self-Selected Food Intake. Meeting Abstract. Experimental Biology 2016, April 2-6, 2016, San Diego, CA.Relationship between Human Gut Microbiota and Interleukin 6 Levels in Overweight and Obese Adults-(Abstract Only) Cooper, D., Kim, E., Marco, M., Rust, B., Welch, L., Horn, W.F., Freytag, T.L., Martin, R., Keim, N.L. 2016. Relationship between Human Gut Microbiota and Interleukin 6 Levels in Overweight and Obese Adults. Meeting Abstract. Experimental Biology 2016, April 2-6, 2016, San Diego, CA..Does whole grain consumption alter gut microbiota and satiety?-(Peer Reviewed Journal) Cooper, D.N., Martin, R.J., Keim, N.L. 2015. Does whole grain consumption alter gut microbiota and satiety? Healthcare. 3(2)364-392. doi: 10.3390/healthcare3020364.A dose-response of consuming high fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults-(Peer Reviewed Journal) Stanhope, K.L., Medici, V., Bremer, A.A., Lee, V., Lam, H.D., Nunez, M.V., Chen, G.X., Keim, N.L., Havel, P.J. 2015. A dose-response of consuming high fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. American Journal of Clinical Nutrition. 101(6):1144-1154. doi: 10.3945/ajcn.114.100461.Identifying nutrients that are under-reported by an automated 24-hour dietary recall method in overweight and obese women after weight loss-(Abstract Only) Widaman, A.M., Burnett, D.J., Miller, B., Witbract, M., Keim, N.L., Laugero, K.D. 2015. Identifying nutrients that are under-reported by an automated 24-hour dietary recall method in overweight and obese women after weight loss. Meeting Abstract. 2015 Academy of Nutrition & Dietetics Annual Meeting , Nashville TN, October 3-6, 2015.Fructose and high fructose corn syrup-() Keim, N.L., Stanhope, K.L., Havel, P.J. 2016. Fructose and high fructose corn syrup. In: Caballero, B., editor. Encyclopedia of Food and Health. Academic Press. p. 119-124.Does mere exposure mediate sensitivity to bitter taste on consumer liking and acceptability of whole grain foods?-(Abstract Only) De Leon, A., Giovanni, M., Horn, W.F., Burnett, D., Keim, N.L. 2015. Does mere exposure mediate sensitivity to bitter taste on consumer liking and acceptability of whole grain foods?. Meeting Abstract. Experimental Biology 2015, Boston, MA March 28 – April 1, 2015.Short chain fatty acid production and glucose responses by methane producers-(Abstract Only) Rust, B., Gray, I.J., Keifer, D., Newman, J.W., Cooper, D., Welch, L., Horn, W.F., Marco, M., Pelkman, C., Keim, N.L. 2014. Short chain fatty acid production and glucose responses by methane producers. Meeting Abstract. Experimental Biology Meeting, Boston MA, March 28-April 1, 2015.Breakfast skippers display a disrupted cortisol rhythm and elevated blood pressure-(Peer Reviewed Journal) Whitbracht, M.G., Keim, N.L., Forester, S., Widaman, A., Laugero, K.D. 2015. Breakfast skippers display a disrupted cortisol rhythm and elevated blood pressure. Physiology and Behavior. 140:215-221. doi:10.1016/j.physbeh.2014.12.044.Does mere exposure change implicit associations between whole grain foods and taste?-(Peer Reviewed Journal)Chronic stress is associated with indicators of diet quality in habitual breakfast skippers-(Peer Reviewed Journal) Widaman, A.M., Witbracht, M.G., Forester, S.M., Laugero, K.D., Keim, N.L. 2016. Chronic stress is associated with indicators of diet quality in habitual breakfast skippers. Journal of the Academy of Nutrition and Dietetics. 116(11):1776-1784. doi: 10.1016/j.jand.2016.03.016.Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin, and adiponectin: Relationships with metabolic outcomes-(Peer Reviewed Journal) Resvani, R., Cianflone, K., Mcgahan, J.P., Berglund, L., Bermer, A.A., Keim, N.L., Griffen, S.C., Havel, P.J., Stanhope, K.L. 2013. Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin, and adiponectin: Relationships with metabolic outcomes. Obesity. 10.1002.Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin-(Peer Reviewed Journal) Campbell, C., Grapov, D., Fiehn, O., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Gustafson, M.B., Keim, N.L., Newman, J.W., Hunter, G.R., Fernandez, J.R., W. Timothy, G., Harper, M., Hoppel, C.L., Meissen, J.K., Takeuchi, K., Adams, S.H. 2014. Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin. PLoS One. 9(1):e84260. DOI: 10.1371/journal.pone.0084260.Habitual physical activity and plasma metabolomics patterns distinguish individuals with low- versus high-weight loss during controlled energy restriction-(Peer Reviewed Journal) Piccolo, B., Van Loan, M.D., Gertz, E.R., Woodhouse, L.R., Souza, E., Gustafson, M.B., Campbell, C., Fiehn, O., Keim, N.L., Adams, S.H., Newman, J.W. 2015. Habitual physical activity and plasma metabolomics patterns distinguish individuals with low- versus high-weight loss during controlled energy restriction. Journal of Nutrition. 145(4):681-690. doi: 10.3945/jn.114.201574.Dietary whole grain-microbiota interactions: insights into mechanisms for human health-(Peer Reviewed Journal) Keim, N.L., Martin, R.J. 2015. Dietary whole grain-microbiota interactions: insights into mechanisms for human health. Advances in Nutrition. 5:556–557. doi: 10.3945/an.114.006536.Association between subcutaneous white adipose tissue and serum 25-hydroxyvitamin D in overweight and obese adults-(Peer Reviewed Journal) Piccolo, B.D., Dolnikowski, G., Seyoum, E., Thomas, A., Gertz, E.R., Souza, E.C., Keim, N.L., Adams, S.H., Newman, J.W., Woodhouse, L.R., Van Loan, M.D. 2013. Association between subcutaneous white adipose tissue and serum 25-hydroxyvitamin D in overweight and obese adults. American Journal of Clinical Nutrition. 5(9), 3352-3366. DOI:10.3390/nu5093352.Vegetable variety is a key to improved diet quality in low-income women in California-(Peer Reviewed Journal)Estimating dietary costs of low-income women in California: A comparison of two approaches-(Peer Reviewed Journal) Aaron, G., Keim, N.L., Drewnowski, A., Townsend, M. 2013. Estimating dietary costs of low-income women in California: A comparison of two approaches. American Journal of Clinical Nutrition. 97(4):835:841.Dairy food consumption and meal-induced cortisol response interact to influence weight loss in overweight women undergoing a 12-week meal-controlled weight loss intervention-(Peer Reviewed Journal) Witbracht, M., Van Loan, M.D., Adams, S.H., Keim, N.L., Laugero, K.D. 2012. Dairy food consumption and meal-induced cortisol response interact to influence weight loss in overweight women undergoing a 12-week meal-controlled weight loss intervention. Journal of Nutrition. 143(1):45-52.Energy assessment: physical activity-()Variations in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful?-(Peer Reviewed Journal) Krishnan, S., Newman, J.W., Hembrooke, T.A., Keim, N.L. 2012. Variations in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful?. Nutrition and Metabolism. 9:26.Variation in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful?-(Peer Reviewed Journal) Krishnan, S., Newman, J.W., Hembrooke, T.A., Keim, N.L. 2012. Variation in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful?. Journal of Nutrition and Metabolism. 9(1):26.Association between vitamin D metabolites in fat tissue and serum 25-hydroxy vitamin D in overweight and obese adults-(Abstract Only) Piccolo, B.D., Gertz, E.R., Thomas, A.P., Keim, N.L., Adams, S.H., Seyoum, E., Dolnikowski, G., Van Loan, M.D. 2012. Association between vitamin D metabolites in fat tissue and serum 25-hydroxy vitamin D in overweight and obese adults. Journal of Federation of American Societies for Experimental Biology. 386.4.Within subject variation of satiety hormone responses to a
standard lunch-(Abstract Only) Forester, S.M., Witbracht, M., Horn, W.F., Keim, N.L., Laugero, K.D. 2012. Within subject variation of satiety hormone responses to a standard lunch. Journal of Federation of American Societies for Experimental Biology. 639.5.Increased dietary saturated fat intake is negatively associated
with compliance to exercise regimen and improvement in
fitness parameters.-(Abstract Only) Krishnan, S., Gustafson, M., Sheets, C., Souza, E., Keim, N.L. 2012. Increased dietary saturated fat intake is negatively associated with compliance to exercise regimen and improvement in fitness parameters.. Journal of Federation of American Societies for Experimental Biology. 257.4.Skipping breakfast is associated with lower physical activity energy expenditure in young healthy women-(Abstract Only) Marquez, A.P., Forester, S., Witbracht, M., Campbell, C., Gustafson, M., Keim, N.L. 2012. Skipping breakfast is associated with lower physical activity energy expenditure in young healthy women. Journal of Federation of American Societies for Experimental Biology. 820.21.Circulating concentrations of monocyte chemoattranctant protein-1, plasminogen activator inhibitor-1, & soluble leukocyte adhesion molecule-1 in overweight/obese men/women consuming fructose-or glucose-sweetened beverages-(Peer Reviewed Journal) Cox, C.L., Stanhope, K.L., Marc Schwarz, J., Graham, J.L., Griffen, S.C., Bremer, A.A., Berglund, L., Mcgahan, J.P., Beysen, C., Keim, N.L., Havel, P.J. 2011. Circulating concentrations of monocyte chemoattranctant protein-1, plasminogen activator inhibitor-1, & soluble leukocyte adhesion molecule-1 in overweight/obese men/women consuming fructose-or glucose-sweetened beverages. Journal of Clinical Endocrinology and Metabolism. 96(12):E2034-E2038.Assessing face validity of a physical activity questionnaire for Spanish-speaking women in California-(Peer Reviewed Journal) Banna, J.C., Keim, N.L., Townsend, M.S. 2011. Assessing face validity of a physical activity questionnaire for Spanish-speaking women in California. Journal of Extension. Vol.49:5.Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women-(Peer Reviewed Journal) Cox, C., Stanhope, K.L., Schwarz, J.M., Graham, J.L., Havel, P.J., Keim, N.L. 2011. Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women. American Journal of Clinical Nutrition. Eur J Clin Nutr. 2012 Feb;66(2):201-8.Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholestrol, and apolipoprotein-b in young men and women-(Peer Reviewed Journal) Stanhope, K., Bremer, A.A., Natkajima, K., Ito, Y., Nakano, T., Chen, G., Fong, T.H., Lee, V., Menorca, R., Keim, N.L., Havel, P.J. 2011. DIFFERENTIAL EFFECTS OF CONSUMING GLUCOSE-, FRUCTOSE-, AND HIGH FRUCTOSE CORN SYRUP-SWEETENED BEVERAGES FOR 2 WEEKS ON FASTING AND POSTPRANDIAL LIPID AND LIPOPROTEIN PROFILES IN YOUNG MEN AND WOMEN. Journal of Clinical Endocrinology and Metabolism. 96(10):E1596-1605.Dairy foods in a moderate energy restricted diet do not enhance central fat, weight & intra-abdominal adipose tissue loss or reduce adipocyte size & inflammatory markers in overweight & obese adults; Controlled feeding study-(Peer Reviewed Journal) Van Loan, M.D., Keim, N.L., Adams, S.H., Souza, E., Woodhouse, L.R., Thomas, A., Witbracht, M., Gertz, E.R., Piccolo, B., Brenner, A.R., Spurlock, M. 2011. Dairy foods in a moderate energy restricted diet do not enhance central fat, weight & intra-abdominal adipose tissue loss or reduce adipocyte size & inflammatory markers in overweight & obese adults; Controlled feeding study. Journal of Obesity.  10.1155/2011/989657.Performance on the Iowa gambling task is related to magnitude of weight loss and salivary cortisol in a diet-induced weight loss intervention in overweight women-(Peer Reviewed Journal) Witbracht, M.G., Laugero, K.D., Van Loan, M.D., Adams, S.H., Keim, N.L. 2011. Performance on the Iowa gambling task is related to magnitude of weight loss and salivary cortisol in a diet-induced weight loss intervention in overweight women. Physiology and Behavior. 106(2):291-297. https://doi.org/10.1016/j.physbeh.2011.04.035.Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-hour glucose and insulin excursions-(Peer Reviewed Journal) Stanhope, K., Griffin, S.C., Bremer, A.A., Schaefer, E., Natkajima, K., Schwarz, J.M., Beysen, C., Berglund, L., Keim, N.L., Havel, P.J. 2011. METABOLIC RESPONSES TO PROLONGED CONSUMPTION OF GLUCOSE- AND FRUCTOSE-SWEETENED BEVERAGES ARE NOT ASSOCIATED WITH POSTPRANDIAL OR 24-HOUR GLUCOSE AND INSULIN EXCURSIONS. American Journal of Clinical Nutrition. 94:112-119.Translating the Dietary Guidelines for Americans 2010 to Bring About Real Behavior Change-(Peer Reviewed Journal) Rowe, S., Alexander, N., Almeida, N., Black, R., Burns, R., Bush, L., Crawford, P., Keim, N.L., Kris-Etherton, P., Weaver, C. 2011. Translating the Dietary Guidelines for Americans 2010 to Bring About Real Behavior Change. Journal of American Dietetic Association. 111(1):28-39.In polycystic ovary syndrome, adrenal steroids are regulated differently in the morning versus in response to nutrient intake-(Peer Reviewed Journal) Gurusinghe, D., Gill, S., Almario, R.U., Lee, J., Horn, W.F., Keim, N.L., Kim, K., Kasim-Karakas, S.E. 2009. In polycystic ovary syndrome, adrenal steroids are regulated differently in the morning versus in response to nutrient intake. Fertility and Sterility, 93(4):1192-1193, 2009.Effects of consuming fructose- or glucose-sweetened beverages for 10 weeks on lipids, insulin sensitivity and adiposity-(Peer Reviewed Journal) Stanhope, K.L., Keim, N.L., Griffen, S.C., Bremer, A.A., Graham, J.L., Hatcher, B., Cox, C., Mcgahan, J.P., Seibert, A., Krauss, R.M., Chiu, S., Schaefer, E.J., Ai, M., Otokozawa, S., Nakajima, K., Nakano, T., Beysen, C., Schwarz, J.M., Hellerstein, M.K., Berglund, L., Havel, P.J. 2009. Effects of consuming fructose- or glucose-sweetened beverages for 10 weeks on lipids, insulin sensitivity and adiposity. Journal of Clinical Investigation. 119(5):1322-1334, 2009.Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: Influence of insulin resistance on plasma triglyceride responses-(Peer Reviewed Journal) Teff, K.L., Grudziak, J., Townsend, R.R., Dunn, T.N., Grant, R.W., Adams, S.H., Keim, N.L., Cummings, B.P., Stanhope, K.L., Havel, P.J. 2009. Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: Influence of insulin resistance on plasma triglyceride responses.  J. Clin Endocrinol Metab. 94(5):1562-1959.Less-energy-dense diets of low-income women in California are associated with higher energy-adjusted diet costs-(Peer Reviewed Journal) Townsend, M., Grant, A., Monsivais, P., Keim, N.L., Drewnowski, A. 2009. Lower-energy-density diets of low-income women in California are associated with higher energy-adjusted diet costs. American Journal of Clinical Nutrition. 89:1220-1226, 2009.GLYCEMIC INDEX, CHOLECYSTOKININ, SATIETY AND DISINHIBITION: IS THERE AN UNAPPRECIATED PARADOX FOR OVERWEIGHT WOMEN?-(Peer Reviewed Journal) Burton-Freeman, B., Keim, N.L. 2008. GLYCEMIC INDEX, CHOLECYSTOKININ, SATIETY AND DISINHIBITION: IS THERE AN UNAPPRECIATED PARADOX FOR OVERWEIGHT WOMEN? International Journal of Obesity. 32:1647-1654.Consumption of Fructose- But not Glucose-Sweetened Beverages for 10 Weeks Increases Postprandial Triglyceride and Apolipoprotein B Concentrations in Overweight/Obese Women-(Peer Reviewed Journal) Swarbrick, M.M., Stanhope, K.L., Elliott, S.S., Graham, J.L., Krauss, R.M., Christiansen, M.P., Griffen, S.C., Keim, N.L., Havel, P.J. 2008. Consumption of Fructose- But not Glucose-Sweetened Beverages for 10 Weeks Increases Postprandial Triglyceride and Apolipoprotein B Concentrations in Overweight/Obese Women. Journal of Clinical Endocrinology and Metabolism. 100:947-952, 2008.Twenty-four Hour Endocrine and Metabolic Profiles Following Consumption of High Fructose Corn Syrup-, Sucrose- Fructose-, and Glucose-Sweetened Beverages with Meals-(Peer Reviewed Journal) Stanhope, K.L., Griffen, S.C., Bair, B.R., Swarbrick, M.M., Keim, N.L., Havel, P.J. 2008. Twenty-four Hour Endocrine and Metabolic Profiles Following Consumption of High Fructose Corn Syrup-, Sucrose- Fructose-, and Glucose-Sweetened Beverages with Meals. American Journal of Clinical Nutrition. Amer. J. Clin. Nutr., 87:1194-1203, 2008.RESPONSE OF SELENIUM STATUS INDICATORS TO SUPPLEMENTATION OF HEALTHY NORTH AMERICAN MEN WITH HIGH-SELENIUM YEAST-(Peer Reviewed Journal) Hawkes, W.C., Keim, N.L., Richter, D., Gustafson, M.B., Gale, B., Mackey, B.E., Bonnel, E. 2008. Response of selenium status indicators to supplementation of healthy north american men with high-selenium yeast. Journal of Trace Elements in Medicine and Biology. Vol.122:107-121, 2008.POSTPRANDIAL MONOCYTE ACTIVATION IN RESPONSE TO MEALS WITH HIGH AND LOW GLYCEMIC LOADS IN OVERWEIGHT WOMEN-(Peer Reviewed Journal) Keim, N.L., Motton, D.D., Tenorio, F.A., Horn, W.F., Rutledge, J.C. 2007. POSTPRANDIAL MONOCYTE ACTIVATION IN RESPONSE TO MEALS WITH HIGH AND LOW GLYCEMIC LOADS IN OVERWEIGHT WOMEN. American Journal of Clinical Nutrition.  85:60-65, 2007.BEST PRACTICE METHODS TO APPLY TO MEASUREMENT OF RESTING METABOLIC RATE, A SYSTEMATIC REVIEW-(Peer Reviewed Journal) Compher, C., Frankenfield, D., Keim, N.L., Roth-Yousey, L. Best practice methods to apply to measurement of resting metabolic rate, a systematic review. Journal Of The American Dietetic Association. 106:881-903, 2006.RAMAN SPECTROSCOPIC ANALYSIS OF BIOCHEMICAL CHANGES IN INDIVIDUAL TRIGLYCERIDE-RICH LIPOPROTEINS IN THE PRE- AND POSTPRANDIAL STATE.-(Peer Reviewed Journal) Chan, J.W., Motton, D., Rutledge, J.C., Keim, N.L., Huser, T. Raman spectroscopic analysis of biochemical changes in individual triglyceride-rich lipoproteins in the pre- and postprandial state.. Analytical Chemistry 77:5870-5876, 2005.VISUALLY ENHANCED EVALUATION FOR LOW-INCOME CLIENTS-(Abstract Only) Townsend, M.S., Silva, K., Follett, J.R., Keim, N.L., Martin, A.C., Metz, D.L., Swanson-Wooten, P.C., Sugarman, S.B. Visually enhanced evaluation for low-income clients. Journal of Nutrition Education and Behavior. 2005; vol.37 Suppl 1:S49SIZE ACCEPTANCE AND INTUITIVE EATING IMPROVE HEALTH FOR OBESE FEMALE CHRONIC DIETERS-(Peer Reviewed Journal) Bacon, L., Stern, J.S., Van Loan, M.D., Keim, N.L. Size acceptance and intuitive eating improves health for obese female chronic dieters. Journal Of The American Dietetic Association.  J Am Diet Assoc. 105(6):929-936, 2005.FRUCTOSE-() Keim, N.L., Havel, P.J. Fructose. Encyclopedia of Human Nutrition, 2nd edition. Elsevier Ltd. 2005, Vol.2;351-356.CARBOHYDRATES-() Keim, N.L., Levin, R.J., Havel, P.J. Carbohydrates. Modern Nutrition in Health and Disease, 10th edition, Lippincott Williams & Williams, 2005.  Pp. 62-82.AMERICAN'S OBESITY EPIDEMIC: MEASURING PHYSICAL ACTIVITY TO PROMOTE AN ACTIVE LIFESTYLE-(Peer Reviewed Journal) Keim, N.L., Blanton, C.A., Kretsch, M.J. American's obesity epidemic: measuring physical activity to promote an active lifestyle. Journal Of The American Dietetic Association.  J Am Diet Assoc. 2004;104:1398-1409.RESTRAINED EATING BEHAVIOR AND THE METABOLIC RESPONSE TO DIETARY ENERGY RESTRICTION IN WOMEN-(Peer Reviewed Journal) Keim, N.L., Horn, W.F. 2004. Restrained eating behavior and the metabolic response to dietary energy restriction in women. Obesity Research. 12(1), 2004.DIETARY FRUCTOSE REDUCES CIRCULATING INSULIN AND LEPTIN, ATTENUATES POSTPRANDIAL SUPPRESSION OF GHRELIN AND INCREASES TRIGLYCERIDES IN WOMEN-(Peer Reviewed Journal) Teff, K.T., Elliott, S.S., Tschoep, M., Rader, D., Heiman, M., Townsend, R.R., Keim, N.L., D'Alessio, D., Havel, P.J. 2004. Consuming high-fructose beverages with meals reduces circulating insulin and leptin concentrations and raises plasma ghrelin and triglycerides in normal weight women. Clinical Endocrine Metabolism. 89(6):2963-2972, 2004.LOW BONE MASS IN PRE-MENOPAUSAL CHRONIC DIETING OBESE WOMEN-(Peer Reviewed Journal) Van Loan, M.D., Keim, N.L., Stern, J., Bacon, L. 2004. Low bone mass in pre-menopausal chronic dieting obese women. European Journal of Clinical Nutrition.  European Journal of Clinical Nutrition. 58:966-971.DIETARY SELENIUM INTAKE MODULATES THYROID HORMONE AND ENERGY METABOLISM IN MEN-(Peer Reviewed Journal) Hawkes, W.C., Keim, N.L. 2003. Dietary selenium intake modulates thyroid hormone and energy metabolism in men. Journal of Nutrition. 133:3443-3448, 2003.FRUCTOSE, WEIGHT GAIN, AND THE INSULIN RESISTANCE SYNDROME-(Peer Reviewed Journal) Elliott, S.S., Keim, N.L., Stern, J., Teff, K., Havel, P.J. 2002. FRUCTOSE, WEIGHT GAIN, AND THE INSULIN RESISTANCE SYNDROME. American Journal of Clinical Nutrition 76:911-922, 2002.EVALUATING A 'NON-DIET' WELLNESS INTERVENTION FOR IMPROVEMENT OF METABOLIC FITNESS, PSYCHOLOGICAL WELL-BEING AND EATING AND ACTIVITY BEHAVIORS-(Peer Reviewed Journal) Bacon, L., Keim, N.L., Van Loan, M.D., Derricote, M., Gale, B., Kazaks, A., Stern, J.S. 2002. EVALUATING A 'NON-DIET' WELLNESS INTERVENTION FOR IMPROVEMENT OF METABOLIC FITNESS, PSYCHOLOGICAL WELL-BEING AND EATING AND ACTIVITY BEHAVIORS. International Journal of Obesity 26:854-865, 2002.RELATION BETWEEN CIRCULATING LEPTIN CONCENTRATIONS AND APPETITE DURING     A PROLONGED, MODERATE ENERGY DEFICIT IN WOMEN-(Peer Reviewed Journal)WEIGHT LOSS INCREASED WITH CONSUMPTION OF LARGE MORNING MEALS AND FAT-FREE MASS IS PRESERVED WITH LARGE MEALS EVENING IN WOMEN ON A CONTROLLED WEIGHT REDUCTION REGIMEN-(Peer Reviewed Journal)THE EFFECTS OF DIETARY SELENIUM ON THYROID HORMONES, ENERGY METABOLISM,    SEMEN QUALITY, AND IMMUNE FUNCITON IN HEALTHY MEN-(Abstract Only)THE EFFECTS OF CROSS-TRAINING ON ENERGY EXPENDITURE AND UTILIZATION OF     OVERWEIGHT WOMEN-(Abstract Only)TIME OF MEAL INGESTION AFFECTS LOSS OF WEIGHT AND FAT-FREE MASS (FFM) IN   WOMEN-(Abstract Only)
            Prominent ProjectsImproving Public Health by Understanding Metabolic and Bio-Behavioral Effects of Following Recommendations in the Dietary Guidelines for AmericansIn-House Appropriated (D)Accession Number:436165Almonds Snacks and Satiety: A Randomized Intervention Trial Examining Acute and Chronic EffectsNon-Assistance Cooperative Agreement (S)Accession Number:436414Using an Integrated Model to Determine How Chronic Dairy Consumption Affects Factors Linked to Food Intake & SatietyTrust Fund Cooperative Agreement (T)Accession Number:430257Grape Seed Flour Manufacture and Study of Human Metabolic ResponseTrust Fund Cooperative Agreement (T)Accession Number:430521Almonds and Satiety: A Randomized Intervention Trial Examining Acute and Chronic EffectsTrust Fund Cooperative Agreement (T)Accession Number:435932
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