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ARS Home Pacific West Area Davis, California Western Human Nutrition Research Center Obesity and Metabolism Research People Brian J Bennett





Bennett Labheadline bar **BENNETT LAB** /ARSUserFiles/52161/picture/Bennett Lab 2020 (2).jpg   Research Scientist
                              **Brian Bennett , Ph.D.**
Research Leader
Office:(530) 752-4417>
Email address: brian.bennett@usda.gov
Google Scholar page
**Research Interests**
Genetics: Chronic diseases such as obesity, diabetes and atherosclerosis have both genetic and environmental risk factors, but understanding the complex interactions between susceptibility genes and the environment has been difficult.  I am particularly interested in using integrative genetic studies, also called systems genetics, to elucidate the genetic component of these chronic metabolic diseases. The goal of this work is to identify individual genes and/or the interaction of groups of genes, also called biologic networks, contributing to these diseases.
Microbiota derived metabolites and disease risk: Diet is an important risk factor for cardiovascular disease risk and integration of circulating small molecule metabolites, metabolomics, provide potential biomarkers of the disease severity and mechanisms by which atherosclerosis develops.   For example, in collaboration with investigators at the Cleveland Clinic, we have recently identified a novel metabolite of dietary choline called trimethylamine N-oxide (TMAO) that is predictive of atherosclerosis in humans and mice.  Integrative analysis of this metabolite with expression mapping has confirmed begun to elucidate the mechanisms by which these traits, atherosclerosis, metabolites and transcripts, are related.
**Bennett Lab Themes**
 Research Team
                              **ARS Employees**
Erik Gertz
**UC Davis Collaborators**
Nazmul Huda
Phoebe Yam
Kristen James
**Undergraduate Students**
Jocelyn Crowell
**Alumni**
Alexa Rindy
Claire Connelly
 Selected Publications(Clicking on the reprint iconReprint Icon  will take you to the publication reprint.)Ectopic expression of the Stabilin2 gene triggered by an IAP element in DBA/2J strain of mice-(Peer Reviewed Journal) Maeda-Smithies, N., Hiller, S., Dong, S., Suk Kim, H., Bennett, B.J., Kayashima, Y. 2020. Ectopic expression of the Stabilin2 gene triggered by an IAP element in DBA/2J strain of mice. PLoS Genetics. https://doi.org/10.1007/s00335-019-09824-1.Diesel exhaust particles dysregulate multiple immunological pathways in murine macrophages: Lessons from microarray and scRNA-seq technologies-(Peer Reviewed Journal) Bhetraratana, M., Orozco, L.D., Hong, J., Diamante, G., Majid, S., Bennett, B.J., Ahn, I., Yang, X., Lusis, A.J., Araujo, J.A. 2019. Diesel exhaust particles dysregulate multiple immunological pathways in murine macrophages: Lessons from microarray and scRNA-seq technologies . Archives of Biochemistry and Biophysics. https://doi.org/10.1016/j.abb.2019.108116.microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO-(Peer Reviewed Journal) Coffey, A.R., Smallwood, T.L., Albright, J., Hua, K., Kanke, M., Pomp, D., Bennett, B.J., Sethupathy, P. 2019. microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO. Physiological Genomics. 51(2):59-71. https://doi.org/10.1152/physiolgenomics.00079.2018.Adropin: an endocrine link between the biological clock and cholesterol homeostasis.-(Peer Reviewed Journal) Ghoshal, S., Stevens, J.R., Billon, C., Giradet, C., Situala, S., Leon, A.S., Rao, D., Skinner, J.S., Rankinen, T., Bouchard, C., Nunez, M.V., Stanhope, K.L., Howatt, D.A., Daugherty, A., Zhang, J., Schuelke, M., Weiss, E.P., Burris, T.P., Havel, P.J., Butler, A.A., Bennett, B.J., Sethupathy, P. 2017. Adropin: an endocrine link between the biological clock and cholesterol homeostasis. Molecular Metabolism. 8:51-64. https://doi.org/10.1016/j.molmet.2017.12.002.Improving metabolic health through precision dietetics in mice-(Peer Reviewed Journal) Barrington, W.T., Wulfridge, P., Gunaratna, R.T., Rojas, C.M., Howe, S.Y., Perry, A., Hua, K., Hansen, K.D., Fuchs-Young, R., Bennett, B.J., Pomp, D., Feinberg, A.P., Threadgill, D.W. 2018. Improving metabolic health through precision dietetics in mice. Genetics. 208:399-417. https://doi.org/10.1534/genetics.117.300536.Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr-/- mice-(Peer Reviewed Journal) Liyang, Z., Cozzo, A.J., Johnson, A.R., Christensen, T., Freemerman, A.J., Bear, J.E., Rotty, J.D., Bennett, B.J., Makowski, L. 2017. Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr-/- mice. Atherosclerosis. 266:182-189. https://doi.org/10.1016/j.atherosclerosis.2017.10.009.Systems genetics identifies a co-regulated module of liver microRNAs associated with plasma LDL cholesterol in murine diet-induced dyslipidemia-(Peer Reviewed Journal) Coffey, A.R., Smallwood, T.L., Albright, J., Hua, K., Kanke, M., Pomp, D., Bennett, B.J., Sethupathy, P. 2017. Systems genetics identifies a co-regulated module of liver microRNAs associated with plasma LDL cholesterol in murine diet-induced dyslipidemia. PLoS Genetics. 49(11):618-629. https://doi.org/10.1152/physiolgenomics.00050.2017.The genetic architecture of coronary artery disease: current knowledge and future opportunities-() Hartiala, J., Schwartzman, W.S., Gabbay, J., Ghazalpour, A., Bennett, B.J., Allayee, H. 2017. The genetic architecture of coronary artery disease: current knowledge and future opportunities. Current Atherosclerosis Reports. 19(2):6. doi: 10.1007/s11883-017-0641-6.
 Prominent ProjectsImproving Public Health by Understanding Metabolic and Bio-Behavioral Effects of Following Recommendations in the Dietary Guidelines for AmericansIn-House Appropriated (D)Accession Number:436165Systems Genetic Studies of TMAO regulation and AtherosclerosisInteragency Reimbursable Agreement (I)Accession Number:432270Systems Genetic Studies of TMAO Regulation and AtherosclerosisNon-Assistance Cooperative Agreement (S)Accession Number:432639Metabolomic Approaches to Dietary InterventionsNon-Assistance Cooperative Agreement (S)Accession Number:433153Almonds Snacks and Satiety: A Randomized Intervention Trial Examining Acute and Chronic EffectsNon-Assistance Cooperative Agreement (S)Accession Number:436414Improving the Dietary Guidelines for Americans by Understanding Genetic and Dietary Interactions in MiceNon-Assistance Cooperative Agreement (S)Accession Number:437216Adequate Beef Consumption does not Increase Plasma Trimethylamine N-oxide (TMAO), in Free Living HumansTrust Fund Cooperative Agreement (T)Accession Number:413494Mothers, Infants and Lactation Quality-Extra Analyses (MILQ II) ProjectTrust Fund Cooperative Agreement (T)Accession Number:436408
 Methods, Technique and Software
                              **Methods and Technique**


        
        
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            Last Modified:
3/18/2020

    

    
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