UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





Form 10-K/A

(Amendment No. 1)







|☒ | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended December 31, 2017

or



|☐ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from                
to

Commission file number: 000-30171





SANGAMO
THERAPEUTICS, INC.

(Exact name of registrant as specified in its charter)







|                                                               |  |                                    
|-------------------------------------------------------------- |  | -----------------------------------
|Delaware                                                       |  | 68-0359556                         
|(State or other jurisdiction of
incorporation or organization) |  | (I.R.S. EmployerIdentification No.)
|                                                               | 
|501 Canal Boulevard,
Richmond, California                      |  | 94804                              
|(Address of principal executive offices)                       |  | (Zip Code)                         

(510) 970-6000

(Registrants telephone number, including area code)

None

Securities
registered pursuant to Section 12(b) of the Act:



|                                        |  |                                          
|--------------------------------------- |  | -----------------------------------------
|Title of Each
Class                     |  | Name of Each Exchange on
Which Registered
|Common Stock, $0.01 par value per share |  | Nasdaq Global Select Market              

Securities registered pursuant to Section 12(g) of the Act: None





Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities
Act.    Yes  ☒    No  ☐

Indicate by check mark if the registrant
is not required to file reports pursuant to Section 13 or Section 15(d) of the Exchange Act.    Yes  ☐    No  ☒

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past
90 days.    Yes  ☒    No  ☐

Indicate by check mark whether
the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405
of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    Yes  ☒    No  ☐

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of
Regulation S-K (§ 229.405 of this chapter) is not contained herein, and will not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated
by reference in Part III of this Form 10-K or any amendment to this Form 10-K.  ☒

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a
non-accelerated filer, a smaller reporting company, or emerging growth company. See definition of large accelerated filer, accelerated filer, smaller reporting company and
emerging growth company in Rule 12b-2 of the Exchange Act.



|                        |  |                                                  |  |                           |  |  
|----------------------- |  | ------------------------------------------------ |  | ------------------------- |  | -
|Large accelerated filer |  | ☒                                                |  | Accelerated filer         |  | ☐
|                        |  |                                                  | 
|Non-accelerated filer   |  | ☐  (Do not check if a smaller reporting company) |  | Smaller reporting company |  | ☐
|                        |  |                                                  | 
|                        |  |                                                  |  | Emerging growth company   |  | ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended
transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the
Exchange Act).    Yes  ☐    No  ☒

The aggregate market value of
the voting stock held by non-affiliates of the registrant based upon the closing sale price of the common stock on June 30, 2017 (the last business day of the registrants most recently completed
second fiscal quarter), as reported on the Nasdaq Global Select Market was $734,155,954. For purposes of this calculation, directors and executive officers of the registrant have been deemed affiliates. This determination of affiliate status is not
necessarily a conclusive determination for other purposes.

As of February 15, 2018, a total of 86,338,976 shares of common stock
$0.01 par value per share were outstanding.

DOCUMENTS INCORPORATED BY REFERENCE

Certain information required by Part III, Items 10-14 of this Form
10-K is incorporated by reference to the registrants definitive Proxy Statement for the 2018 Annual Meeting of Stockholders to be filed with the Securities and Exchange Commission pursuant to Regulation
14A not later than 120 days after the end of the fiscal year covered by this Form 10-K, provided that if such Proxy Statement is not filed within such period, such information will be included in an amendment
to this Form 10-K to be filed within such 120-day period.









---

TABLE OF CONTENTS

Form 10-K/A

(Amendment No. 1)

PART IV



|         |  |                                            |  |  
|-------- |  | ------------------------------------------ |  | -
|Item 15. |  | Exhibits and Financial Statement Schedules |  | 4



2



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EXPLANATORY NOTE

Sangamo Therapeutics, Inc. (the Company) is filing this Amendment No. 1 to Annual Report on Form 10-K/A (this Amendment) to amend the Companys Annual Report on Form 10-K for the fiscal year ended December 31, 2017, as filed with the Securities and
Exchange Commission (the SEC) on March 1, 2018 (the Form 10-K). This Amendment is being filed solely to re-file Exhibit 10.40 to the Form 10-K (the Exhibit) and in connection therewith, to amend Part IV, Item 15 of the Form 10-K. Certain provisions of the Exhibit were redacted in accordance
with the Companys application for confidential treatment with the SEC. In response to SEC comments, the Exhibit, as re-filed, restores certain provisions that had previously been
redacted. In addition, as required by Rule 12b-15 under the Securities Exchange Act of 1934, as amended, new certifications by the Companys principal executive officer and principal financial officer are
filed as exhibits to this Amendment.

No attempt has been made in this Amendment to modify or update the other disclosures presented in
the Form 10-K. This Amendment does not reflect events occurring after the filing of the original Form 10-K (i.e., those events occurring after March 1, 2018)
or modify or update those disclosures that may be affected by subsequent events. Such subsequent matters are addressed in subsequent reports filed with the SEC. Accordingly, this Amendment should be read in conjunction with the Form 10-K and the Companys other filings with the SEC.



3



---

PART IV

ITEM 15  EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

(a) The following documents are included as part of the Companys Annual Report on Form 10-K filed
with the SEC on March 1, 2018 (the Form 10-K):

1. Financial StatementsSee
Index to Consolidated Financial Statements in Item 8 of the Form 10-K.

2. Financial
Statement SchedulesNot Applicable.

3. Exhibits



|              |  |                                                                                                                                                                                                            
|------------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description of
Document                                                                                                                                                                                    
|              | 
|3.1           |  | Seventh Amended and Restated Certificate of Incorporation, as amended (incorporated by reference to Exhibit 
3.1 to the Companys Quarterly Report on Form 10-Q filed August 9, 2017).                     
|              | 
|3.2           |  | Second Amended and Restated Bylaws, as amended (incorporated by reference to Exhibit 
3.2 to the Companys Quarterly Report on Form 10-Q filed August 9, 2017).                                            
|              | 
|4.1           |  | Form of Specimen Common Stock Certificate (incorporated by reference to Exhibit 
4.1 to the Companys Current Report on Form8-K filed January 6, 2017).                                                    
|              | 
|10.1(+)       |  | Amended and Restated 2013 Stock Incentive Plan (the 2013 Plan) (incorporated by reference to Exhibit 
99.1 to the Companys Current Report on Form8-K filed November 14, 2017).                          
|              | 
|10.2(+)       |  | Form of Restricted Stock Unit Award Agreement under the 2013 Plan (incorporated by reference to Exhibit 10.2 to the Companys Annual Report
on Form 10-K filed March 1, 2018).                             
|              | 
|10.3(+)       |  | Form of Notice of Grant of Stock Option under the 2013 Plan (incorporated by reference to Exhibit 
10.3 to the Companys Current Report on Form 8-K filed June 14, 2013).                                  
|              | 
|10.4(+)       |  | Form of Stock Option Agreement under the 2013 Plan (incorporated by reference to Exhibit 
10.4 to the Companys Current Report on Form 8-K filed June 14, 2013).                                           
|              | 
|10.5(+)       |  | Form of Notice of Grant of Stock Option  Director Initial Grant under the 2013 Plan (incorporated by reference to Exhibit 10.5
 to the Companys Current Report on Form 8-K filed June 14, 2013).         
|              | 
|10.6(+)       |  | Form of Notice of Grant of Stock Option  Director Annual Grant under the 2013 Plan (incorporated by reference to Exhibit 10.6
 to the Companys Current Report on Form 8-K filed June 14, 2013).          
|              | 
|10.7(+)       |  | Form of Automatic Stock Option Agreement under the 2013 Plan (incorporated by reference to Exhibit 
10.7 to the Companys Current Report on Form 8-K filed June 14, 2013).                                 
|              | 
|10.8(+)       |  | 2010 Employee Stock Purchase Plan (incorporated by reference to Appendix B to the Companys Definitive Proxy Statement on Schedule 14A filed April
 21, 2010).                                             
|              | 
|10.9(+)       |  | Executive Severance Plan (incorporated by reference to Exhibit 10.4 to the Companys Quarterly Report on Form 10-Q filed May 10, 2017).                                                                    
|              | 
|10.10(+)      |  | Form of Indemnification Agreement (incorporated by reference to Exhibit 
10.2 to the Companys Quarterly Report on Form 10-Q filed August 6, 2015).                                                        
|              | 
|10.11(+)      |  | Employment Agreement between the Company and Alexander (Sandy) Macrae, dated May 
17, 2016 (incorporated by reference to Exhibit 10.1 to the Companys Quarterly Report on Form 10-Q filed August 4, 2016).
|              | 
|10.12(+)      |  | Employment Agreement between the Company and Kathy Yi, dated February 
28, 2017 (incorporated by reference to Exhibit 10.1 to the Companys Quarterly Report on Form 10-Q filed May 10, 2017).             
|              | 
|10.13(+)      |  | Offer Letter between the Company and Curt A. Herberts, dated August 
16, 2010 (incorporated by reference to Exhibit 10.13 to the Companys Annual Report on Form 10-K filed March 1, 2018).                
|              | 
|10.14(+)      |  | Employment Agreement between the Company and Edward Conner, dated November 
1, 2016 (incorporated by reference to Exhibit 10.3 to the Companys Quarterly Report on Form 10-Q filed May 10, 2017).         



4



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|              |  |                                                                                                                                                                                                                                                                                      
|------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description of
Document                                                                                                                                                                                                                                                              
|              | 
|10.15(+)      |  | Amended and Restated Employment Agreement between the Company and H. Ward Wolff, dated December 
31, 2008 (incorporated by reference to Exhibit 10.26 to the Companys Annual Report on Form 10-K filed March 3, 2009).                                                              
|              | 
|10.16(+)      |  | Separation Agreement between the Company and Dale Ando, dated February 
21, 2017 (incorporated by reference to Exhibit 10.16 to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                                       
|              | 
|10.17         |  | Triple Net Laboratory Lease between the Company and Point Richmond R&D Associates II, LLC, dated May 
23, 1997 (incorporated by reference to Exhibit 10.5 to the Companys Registration Statement on FormS-1 (Reg. No.333-30314), as amended, filed February 24, 2000).              
|              | 
|10.18         |  | First Amendment to Triple Net Laboratory Lease between the Company and Point Richmond R&D Associates II, LLC, dated March 12,
 2004 (incorporated by reference to Exhibit 10.20 to the Companys Annual Report on Form10-K filed February 23, 2005).                                 
|              | 
|10.19         |  | Second Amendment to Triple Net Laboratory Lease between the Company and Point Richmond R&D Associates II, LLC, dated March 15,
 2007 (incorporated by reference to Exhibit 10.1 to the Companys Quarterly Report on Form10-Q filed November 4, 2013).                               
|              | 
|10.20         |  | Third Amendment to Triple Net Laboratory Lease between the Company and Point Richmond R&D Associates II, LLC, dated August 1,
 2013 (incorporated by reference to Exhibit 10.2 to the Companys Quarterly Report on Form10-Q filed November 4).                                      
|              | 
|10.21         |  | Lease Agreement between the Company and Marina Boulevard Property, LLC dated November 
3, 2017 (incorporated by reference to Exhibit 10.21 to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                         
|              | 
|10.22         |  | Amended and Restated Sales Agreement between the Company and Cowen LLC, dated May 
26, 2017 (incorporated by reference to Exhibit 1.1 to the Companys Current Report on Form 8-K filed May 26, 2017).                                                                               
|              | 
|10.23         |  | Patent License Agreement between the Company and Massachusetts Institute of Technology, dated May 
9, 1996, as amended by the First Amendment, dated December 10, 1997 (incorporated by reference to Exhibit 10.4 to the Companys Annual Report on Form10-K/A filed April 22, 2010).
|              | 
|10.24        |  | Second Amendment to Patent License Agreement between the Company and Massachusetts Institute of Technology, dated December 
2, 1998 (incorporated by reference to Exhibit 10.8 to the Companys Annual Report on Form10-K filed March 5, 2010).                                      
|              | 
|10.25        |  | Third Amendment to Patent License Agreement between the Company and Massachusetts Institute of Technology, dated September 
1, 1999 (incorporated by reference to Exhibit 10.10 to the Companys Annual Report on Form10-K filed March 5, 2010).                                     
|              | 
|10.26         |  | Fourth Amendment to Patent License Agreement between the Company and Massachusetts Institute of Technology, dated February 
10, 2000 (incorporated by reference to Exhibit 10.11 to the Companys Annual Report on Form10-K filed March 5, 2010).                                    
|              | 
|10.27        |  | Fifth Amendment to Patent License Agreement between the Company and Massachusetts Institute of Technology, effective as of December 15,
 2000 (incorporated by reference to Exhibit 10.14 to the Companys Annual Report on Form10-K filed March 5, 2010).                           
|              | 
|10.28        |  | Sixth Amendment to Patent License Agreement between the Company and Massachusetts Institute of Technology, dated September 
1, 2005 (incorporated by reference to Exhibit 10.17 to the Companys Annual Report on Form10-K filed March 5, 2010).                                     
|              | 
|10.29        |  | Seventh Amendment to Patent License Agreement between the Company and Massachusetts Institute of Technology, dated October 
27, 2006 (incorporated by reference to Exhibit 10.20 to the Companys Annual Report on Form10-K filed March 5, 2010).                                    
|              | 
|10.30         |  | Eighth Amendment to Patent License Agreement between the Company and Massachusetts Institute of Technology, dated February 
1, 2007 (incorporated by reference to Exhibit 10.23 to the Companys Annual Report on Form10-K filed March 5, 2010).                                     
|              | 
|10.31         |  | Ninth Amendment to Patent License Agreement between the Company and Massachusetts Institute of Technology, dated March 
14, 2014 (incorporated by reference to Exhibit 10.3 to the Companys Quarterly Report on Form10-Q filed May 7, 2014).                                        
|              | 
|10.32         |  | Sublicense Agreement between the Company and Johnson & Johnson, dated May 
9, 1996 (incorporated by reference to Exhibit 10.3 to the Companys Annual Report on Form10-K/A filed April 22, 2010).                                                                                    



5



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|               |  |                                                                                                                                                                                                                                                                                                                
|-------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit
Number |  | Description of
Document                                                                                                                                                                                                                                                                                        
|               | 
|10.33          |  | License Agreement between the Company and The Scripps Research Institute, dated March 
14, 2000 (incorporated by reference to Exhibit 10.13 to the Companys Annual Report on Form10-K filed March 5, 2010).                                                                                                   
|               | 
|10.34         |  | Amendment to License Agreement between the Company and The Scripps Research Institute, dated April 
29, 2008 (incorporated by reference to Exhibit 10.32 to the Companys Annual Report on Form10-K filed March 5, 2010).                                                                                      
|               | 
|10.35         |  | Amended and Restated Collaboration and License Agreement between the Company and Shire International GmbH, dated September 
1, 2015 (incorporated by reference to Exhibit 10.1 to the Companys Quarterly Report on Form 10-Q filed October 30, 2015).                                                         
|               | 
|10.36         |  | Global Research, Development and Commercialization Collaboration and License Agreement between the Company and Biogen MA Inc. (Bioverativ
 Inc.), dated January 8, 2014 (incorporated by reference to Exhibit 10.1 to the Companys Quarterly Report on Form10-Q filed May 7, 2014).                           
|               | 
|10.37         |  | Letter Amendment to Global Research, Development and Commercialization Collaboration and License Agreement between the Company and Biogen
 MA Inc. (Bioverativ Inc.), dated December 14, 2015 (incorporated by reference to Exhibit 10.63 to the Companys Annual Report on Form 10-K filed February 18, 2016).
|               | 
|10.38         |  | Letter Agreement and Waiver between the Company and Biogen MA Inc. (Bioverativ Inc.), dated March 
24, 2016 (incorporated by reference to Exhibit 10.1 to the Companys Quarterly Report on Form 10-Q filed May 5, 2016).                                                                                      
|               | 
|10.39         |  | Collaboration and License Agreement between the Company and Pfizer Inc., dated May 
10, 2017 (incorporated by reference to Exhibit 10.1 to the Companys Quarterly Report on Form 10-Q filed August 9, 2017).                                                                                                  
|               | 
|10.40#         |  | Research Collaboration and License Agreement between the Company and Pfizer Inc., dated December 28, 2017.                                                                                                                                                                                                     
|               | 
|21.1           |  | Subsidiaries of the Company (incorporated by reference to Exhibit 21.1 to the Companys Annual Report on Form 10-K filed March 1, 2018)                                                                                                                                                                        
|               | 
|23.1           |  | Consent of Independent Registered Public Accounting Firm (incorporated by reference to Exhibit 23.1 to the Companys Annual Report on Form
10-K filed March 1, 2018).                                                                                                                                          
|               | 
|24.1           |  | Power of Attorney (incorporated by reference to the signature page to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                                                                                                                           
|               | 
|31.1           |  | Rule13a-14(a) Certification of Principal Executive Officer (incorporated by reference to Exhibit 31.1 to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                                                                                        
|               | 
|31.2           |  | Rule13a-14(a) Certification of Principal Financial Officer (incorporated by reference to Exhibit 31.2 to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                                                                                        
|               | 
|31.3           |  | Rule13a-14(a) Certification of Principal Executive Officer.                                                                                                                                                                                                                                                    
|               | 
|31.4           |  | Rule13a-14(a) Certification of Principal Financial Officer.                                                                                                                                                                                                                                                    
|               | 
|32.1*          |  | Certification Pursuant to 18 U.S.C. Section 
1350 (incorporated by reference to Exhibit 32.1 to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                                                                                                 
|               | 
|101.INS        |  | XBRL Instance Document (incorporated by reference to Exhibit 101.INS to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                                                                                                                         
|               | 
|101.SCH        |  | XBRL Taxonomy Extension Schema Document (incorporated by reference to Exhibit 101.SCH to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                                                                                                        
|               | 
|101.CAL        |  | XBRL Taxonomy Extension Calculation Linkbase Document (incorporated by reference to Exhibit 101.CAL to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                                                                                          
|               | 
|101.DEF        |  | XBRL Taxonomy Extension Definition Linkbase Document (incorporated by reference to Exhibit 101.DEF to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                                                                                           
|               | 
|101.LAB        |  | XBRL Taxonomy Extension Label Linkbase Document (incorporated by reference to Exhibit 101.LAB to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                                                                                                
|               | 
|101.PRE        |  | XBRL Taxonomy Extension Presentation Linkbase Document (incorporated by reference to Exhibit 101.PRE to the Companys Annual Report on Form 10-K filed March 1, 2018).                                                                                                                                         



6



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| | Confidential treatment has been granted for certain information contained in this document pursuant to an order of the Securities and Exchange Commission. Such information has been omitted and filed separately with
the Securities and Exchange Commission.
|- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|# | Confidential treatment has been requested for certain information contained in this document. Such information has been omitted and filed separately with the Securities and Exchange Commission.
|- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(+) | Indicates management contract or compensatory plan or arrangement.
|--- | ------------------------------------------------------------------

|* | The certifications attached as Exhibit 32.1 accompany the Form 10-K pursuant to 18 U.S.C. Section1350, as adopted pursuant to Section906
of the Sarbanes-Oxley Act of 2002, and shall not be deemed filed by the Company for purposes of Section18 of the Securities Exchange Act of 1934, as amended.
|- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



7



---

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this Amendment
No. 1 to its Annual Report on Form 10-K/A to be signed on its behalf by the undersigned, thereunto duly authorized.



|                     |  |  |  |                            |  |                                       
|-------------------- |  |  |  | -------------------------- |  | --------------------------------------
|Date: April 24, 2018 |  |  |  | SANGAMO THERAPEUTICS, INC.
|                     |  |  | 
|                     |  |  |  | By:                        |  | /S/ ALEXANDER MACRAE                  
|                     |  |  |  |                            |  | Alexander Macrae                      
|                     |  |  |  |                            |  | President, and Chief Executive Officer