Exhibit 10.58

AMENDMENT NO. 1 TO  AMENDED AND RESTATED  LOAN AND STOCK PLEDGE AGREEMENT

This
amendment to the Amended and Restated Loan and Stock Purchase Agreement (the "Agreement") is entered into this 9th day of April, 2002, by and among Bionutrics, Inc., a Nevada
corporation ("Borrower"), HealthSTAR Holdings, LLC, ("Holdings"), Ropart Investments, LLC, Xiagen Ltd., Ronald H. Lane, William McCormick, Fred Rentschler, William J. Rittger (collectively,
"Lenders"), and William McCormick, as agent for Lenders ("Agent").

A.    Borrow,
Lenders, and Agent wish to amend the Agreement.

NOW, THEREFORE,the parties, intending to be legally bound, hereby agree as follows:

1.Definition.Unless otherwise set forth herein, all capitalized terms have the meanings specified
to them in the Agreement.

2.Amount of Loan.Section 1 is amended and restated in its entirety as follows:



3.Holdings.Section 7 is amended and restated in its entirety as follows:



4.All Other Terms.All other terms of the Agreement shall remain in full force and effect.

5.Counterparts.This Agreement may be executed in any number of counterparts, each of which will be
deemed to be an original as against any party whose signature appears thereon, and all of which will together constitute one and the same instrument.

IN WITNESS WHEREOF, the parties hereto have executed and delivered this Agreement as of the day and year first above written.

| |  | "Borrower"                            
| |  | --------------------------------------
| |  |                                       
| |  | BIONUTRICS, INC., a Nevada corporation
| |  |                                       
| |  | By:                                   
| |  | Name:                                 
| |  | Title:                                
| |  |                                       

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| |  | Address of Borrower:
2425 East Camelback Road, Suite 650
Phoenix, AZ 85016
Attention: Ronald H. Lane
| |  | ----------------------------------------------------------------------------------------------------
| |  |                                                                                                     
| |  |                                                                                                     
| |  | "Agent"                                                                                             
| |  |                                                                                                     
| |  | William McCormick                                                                                   
| |  |                                                                                                     
| |  | /s/WILLIAM MCCORMICK                                                                                
| |  |                                                                                                     
| |  | Address of Agent:
c/o Inverness
660 Steamboat Road
Greenwich, CT 06830                              
| |  |                                                                                                     
| |  |                                                                                                     
| |  | "Lenders"                                                                                           
| |  |                                                                                                     
| |  | HEALTHSTAR HOLDINGS LLC, as a Lender                                                                
| |  |                                                                                                     
| |  | By:                                                                                                 
| |  | Name:                                                                                               
| |  | Title:                                                                                              
| |  |                                                                                                     
| |  | Address of HealthSTAR Holdings LLC:
100 Woodbridge Center Drive, Suite 202
Woodbridge, NJ 07095     
| |  |                                                                                                     
| |  |                                                                                                     
| |  | Ronald H. Lane, as a Lender                                                                         
| |  |                                                                                                     
| |  | /s/RONALD H. LANE                                                                                   
| |  |                                                                                                     
| |  | Address of Ronald H. Lane:
2425 E. Camelback Road
Suite 650
Phoenix, AZ 85016                       
| |  |                                                                                                     
| |  |                                                                                                     
| |  | William McCormick, as a Lender                                                                      
| |  |                                                                                                     
| |  | /s/WILLIAM M. MCCORMICK                                                                             
| |  |                                                                                                     
| |  | Address of William McCormick:
c/o Inverness
660 Steamboat Road
Greenwich, CT 06830                  

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| |  |                                                                               |                        
| |  | ----------------------------------------------------------------------------- | -----------------------
| |  | Xiagen Ltd., as a Lender                                                     
| |  |                                                                               |                        
| |  | By:                                                                           | /s/WILLIAM M. MCCORMICK
| |  | Name:                                                                         | William M. McCormick   
| |  | Title:                                                                        | President/Chairman     
| |  |                                                                               |                        
| |  | Address of Xiagen Ltd.:
c/o Inverness
660 Steamboat Road
Greenwich, CT 06830 
| |  |                                                                               |                        
| |  |                                                                               |                        
| |  | Ropart Investments, LLC, as a Lender                                         
| |  |                                                                               |                        
| |  | By:                                                                           | /s/TODD A. GOERGEN     
| |  | Name:                                                                         | Todd A. Goergen        
| |  | Title:                                                                        | Managing Member        
| |  |                                                                               |                        
| |  | Address of Ropart Investments LLC:
One East Weaver Street
Greenwich, CT 06831
| |  |                                                                               |                        
| |  |                                                                               |                        
| |  | Frederick B. Rentschler, as a Lender                                         
| |  |                                                                               |                        
| |  | /s/FREDERICK B. RENTSCHLER                                                   
| |  |                                                                               |                        
| |  | Address of Frederick B. Rentschler:
P.O. Box 4710
Cave Creek, AZ 85327       
| |  |                                                                               |                        
| |  |                                                                               |                        
| |  | William J. Ritger, as a Lender                                               
| |  |                                                                               |                        
| |  | /s/WILLIAM J. RITGER                                                         
| |  |                                                                               |                        
| |  | Address of William J. Ritger
623 Ocean Ave.
Sea Girt, NJ 08750               

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