Exhibit 10.57

SECOND AMENDED AND RESTATED CONSOLIDATED  MULTIPLE ADVANCE NON-REVOLVING NOTE

FOR VALUE RECEIVED, Bionutrics, Inc., a Nevada corporation ("Borrower"), hereby promises to pay to the order of William McCormick,
as agent ("Agent"), for the ratable benefit of HealthSTAR Holdings, LLC ("Holdings"), Ropart Investments, LLC, Xiagen Ltd., Ronald H. Lane, William McCormick, Fred Rentschler, William J.
Rittger and any other party who signs this Note as a lender (collectively, "Lenders"), at the office of Agent located at c/o Inverness, 660 Steamboat Road, Greenwich, Connecticut 06830 or at such
other place as Agent may designate, on June 1, 2002, or earlier as required herein (the "Maturity Date"), the sum of One Million Three Hundred Eighty-five Thousand Four Hundred
Dollars ($1,385,400) or such lesser sum as from time to time shall be outstanding hereunder, as reflected in the books and records of Agent, such sum to include the Accreted Interest (defined below),
and, to the extent applicable, shall pay the Default Interest Rate specified below, in accordance with the following terms and conditions:

1.Background.



2.Contracted For Rate of Interest.The contracted for rate of interest of the indebtedness evidenced hereby, without
limitation, shall consist of the following:



---



Borrower
agrees to pay an effective contracted for rate of interest which is the sum of the Accreted Interest referred to insubsection 2(a)above, plus
any additional rate of interest resulting from the application of the Default Interest Rate referred to insubsection 2(b)above, and the Additional
Sums, if any, referred to insubsection 2(c)above.

3.Default Interest Rate.The Default Interest Rate shall be a per annum rate equal to 25%. The principal balance outstanding
hereunder from time to time shall bear interest at the Default Interest Rate from the date of the occurrence of an Event of Default (as hereinafter defined) until the earlier of: (a) the date
on which the principal balance outstanding hereunder, together with all Accreted Interest and other amounts payable hereunder, are paid in full; or (b) the date on which such Event of Default
is timely cured in a manner satisfactory to Agent. The Default Interest Rate shall be payable on the fifth (5th) day of each month.

4.Principal Balance.The principal balance outstanding hereunder at any time shall be the total amount of advances made
hereunder by Lenders less the total amount of payments of principal hereon as reflected in the books and records of Agent with respect to the indebtedness evidenced hereby.

5.Aggregate of Advances.Borrower and Lenders contemplate a series of discretionary advances from time to time hereunder,
even if the principal balance outstanding hereunder has previously been reduced to zero; provided, however, such advances in the aggregate shall not exceed the principal amount first set forth above.
Lenders shall at their discretion make any advance requested by Borrower in accordance with this Note as long as no Event of Default exists on the date of such request. Such advances shall be on a
nonrevolving basis and any reduction in the principal balance outstanding hereunder shall not entitle Borrower to any additional advance to the extent such additional advance in the aggregate with all
prior advances hereunder would exceed the principal amount first set forth above.

6.Requests for Advances and Disbursement of Advances.When Borrower desires an advance under the Loan, Borrower shall make a
written request to Agent for such an advance. Such request shall specify the amount of the advance and the date of disbursement. Agent shall immediately communicate Borrower's request to each of the
Lenders and Lenders shall at their discretion make available to the Agent the appropriate amount of funds to satisfy the disbursement request of Borrower. Agent shall remit the appropriate amounts to
Borrower on the date requested by Borrower. Lenders except for Holdings shall agree among themselves as to the amount to be advanced by each. Holdings shall determine at its discretion when and if to
advance the remaining Seventy Thousand Five Hundred Dollars ($70,500) it is committed to advance under the terms hereof.

7.Payment.This Note shall be payable in full on the earlier of (i) June 1, 2002; (ii) the funding of
any loan or loans in cumulative amounts in excess of one million dollars; or (iii) the issuance by the Borrower of any common stock or preferred stock in cumulative amounts in excess of one
million dollars (iv) the consummation of any corporate transaction including, but not limited to, the sale of any assets, or the sale of the assets or stock of its subsidiary, InCon
Technologies, Inc. for an amount equal to at least two million dollars. Payments received by Agent with respect to the indebtedness evidenced hereby shall be applied in such order and manner as
Agent in his sole and absolute discretion may elect. Payments hereunder shall be made at the address for Agent first set forth above, or at such other address as Agent may specify to Borrower in
writing.

8.Prepayments.Payments may be made at any time, or from time to time, in whole or in part, without penalty, together with
all previously matured Accreted Interest and other charges accrued to

2

---

the date of prepayment. Notwithstanding any prepayment hereof: (a) there will be no change in the due date or amount of scheduled payments due hereunder unless Lenders unanimously agree in
writing to such change; and (b) Borrower's obligations hereunder shall continue in effect and this Note shall remain outstanding, unless and until (i) the principal balance outstanding
hereunder, together with all Accreted Interest and other amounts payable hereunder or in any of the Loan Documents, are paid in full, and (ii) thereafter, upon Borrower's request, Agent
delivers to Borrower the original executed copy of this Note marked "cancelled."

9.Events of Default; Acceleration.The occurrence of any one or more of the following events shall constitute an "Event of
Default" hereunder, and upon such Event of Default, the entire principal balance outstanding hereunder, together with all Accreted Interest and other amounts payable hereunder, at the election of
Agent, shall become immediately due and payable, without any notice to Borrower:



10.Additional Sums.All fees, charges, goods, things in action or any other sums or things of value, other than the interest
resulting from the Accreted Interest and the Default Interest Rate, as applicable, paid or payable by Borrower (collectively, the "Additional Sums"), whether pursuant to this Note, the Loan Documents
or any other document or instrument in any way pertaining to this lending transaction, or otherwise with respect to this lending transaction, that, under the laws of the State of Arizona, may be
deemed to be interest with respect to this lending transaction, for the purpose of any laws of the State of Arizona that may limit the maximum amount of interest to be charged with respect to this
lending transaction, shall be payable by Borrower as, and shall be deemed to be, additional interest, and for such purposes only, the agreed upon and "contracted for rate of interest" of this lending
transaction shall be deemed to be increased by the rate of interest resulting from the Additional Sums. Borrower understands and believes that this lending transaction complies with the usury laws of
the State of Arizona; however, if any interest or other charges in connection with this lending transaction are ever determined to exceed the maximum amount permitted by law, then Borrower agrees
that: (a) the amount of interest or charges payable pursuant to this lending transaction shall be reduced to the maximum amount permitted by law; and (b) any excess amount previously
collected from Borrower in connection with this lending transaction that exceeded the maximum amount permitted by law, will be credited against the principal balance then outstanding hereunder. If the
outstanding principal balance hereunder has been paid in full, the excess amount paid will be refunded to Borrower.

11.Conversion of Note.



3

---



12.Waivers.Except as set forth in this Note or the Loan Documents, to the extent permitted by applicable law, Borrower, and
each person who is or may become liable hereunder, severally waive and agree not to assert: (a) any homestead or exemption rights; (b) demand, diligence, grace, presentment for payment,
protest, notice of nonpayment, nonperformance, extension, dishonor, maturity, protest and default; and (c) recourse to guaranty or suretyship defenses (including, without limitation, the right
to require Lenders to bring an action on this Note). Lenders may, if they unanimously agree, extend the time for payment of or renew this Note, release collateral as security for the indebtedness
evidenced hereby, or release any party from liability hereunder, and any such extension, renewal, release or other indulgence shall not alter or diminish the liability of Borrower or any other person
or entity who is or may become liable on this Note except to the extent expressly set forth in a writing evidencing or constituting such extension, renewal, release or other indulgence.

13.Collection Costs and Expenses.Borrower agrees to pay all costs of collection, including, without limitation, attorneys'
fees, whether or not suit is filed, and all costs of suit and preparation for suit (whether at trial or appellate level), in the event any payment of principal, interest or other amount under the Loan
is not paid when due, or in the event it becomes necessary to protect the Pledged

4

---

Collateral (as defined in the Loan Agreement), or to exercise any other right or remedy under this Note, the Loan Agreement or in the Loan Documents, or in the event Agent or Lenders are made parties
to any litigation because of the existence of this Note, the Loan Agreement or the other Loan Documents or if at any time Lenders should incur any attorneys' fees in any proceeding under any federal
bankruptcy law (or any similar state or federal law) in connection with this Note, the Loan Agreement or the other Loan Documents. In the event of any court proceeding, attorneys' fees shall be set by
the court and not by the jury and shall be included in any judgment obtained by Agent or Lenders, as applicable.

14.No Waiver by Lenders.No delay or failure of Lenders in exercising any right hereunder shall affect such right, nor shall
any single or partial exercise of any right preclude further exercise thereof.

15.Governing Law.This Note shall be governed by and construed and interpreted in accordance with the laws of the State of
Arizona, notwithstanding any Arizona or other conflict-of-laws provision to the contrary.

16.Jurisdiction and Venue.Borrower, Agent, and Lenders hereby expressly agree that in the event any actions or other legal
proceedings are initiated by or against Borrower, Agent or Lenders involving any alleged breach or failure by any party to pay, perform or observe any sums, obligations or covenants to be paid,
performed or observed by it under this Note, the Loan Agreement or the other Loan Documents, or involving any other claims or allegations arising out of the transactions evidenced or contemplated by
this Note, the Loan Agreement or the other Loan Documents, regardless of whether such actions or proceedings shall be for damages, specific performance or declaratory relief or otherwise, such actions
shall be brought in Maricopa County, Arizona, or Middlesex County, New Jersey and Borrower, Agent, and Lenders hereby submit to the jurisdiction of the State of Arizona or New Jersey for such purposes
and agree that the venue of such actions or proceedings shall properly lie in Maricopa County, Arizona or Middlesex County, New Jersey

17.Amendments.No amendment, modification, change, waiver, release or discharge hereof and hereunder shall be effective
unless evidenced by an instrument in writing and signed by the party against whom enforcement is sought.

18.Provisions Severable.The provisions of this Note are independent of and severable from each other, and no provision
shall be affected or rendered invalid or unenforceable by virtue of the fact that for any reason any other or others of them may be invalid or unenforceable in whole or in part. Further, if a court of
competent jurisdiction determines that any provision of this Note is invalid or unenforceable as written, the court may interpret, construe, rewrite or revise such provision, to the fullest extent
allowed by law, so as to make it valid and enforceable consistent with the intent of the parties.

19.Binding Nature.The provisions of this Note shall be binding upon Borrower and the heirs, personal representatives,
successors and assigns of Borrower, and shall inure to the benefit of Lenders and any subsequent holder of all or any portion of this Note, and their respective successors and assigns.

20.Notice.Any notice or other communication with respect to this Note shall: (a) be in writing; (b) be
effective on the day of hand-delivery thereof to the party to whom directed, one day following the day of deposit thereof with delivery charges prepaid with a national overnight delivery
service, or two days following the day of deposit thereof with postage prepaid with the United States Postal Service, by regular first class, certified or registered mail; (c) if directed to
Agent, be addressed to Agent at the address of Agent first set forth above or to such other address as Agent shall have specified by like
notice; (d) if directed to Borrower, be addressed to Borrower at the address for Borrower set forth below Borrower's name, or to such other address as Borrower shall have specified by like
notice; and (e) if directed to one of Lenders, be addressed to Lender at the address for that

5

---

Lender set forth below Lender's name, or to such other address as Lender shall have specified by like notice.

21.Section Headings.The section headings set forth in this Note are for convenience only and shall not have substantive
meaning hereunder or be deemed part of this Note.

22.Construction.This Note shall be construed as a whole in accordance with its fair meaning and without regard to or taking
into account any presumption or other rule of law requiring construction against the party preparing this Note.

IN WITNESS WHEREOF, Borrower has executed this Note as of the 9th day of April, 2002.

|                                                                                          |  | "Borrower"                                                                                          
|----------------------------------------------------------------------------------------- |  | ----------------------------------------------------------------------------------------------------
|                                                                                          |  |                                                                                                     
|                                                                                          |  | BIONUTRICS, INC., a Nevada corporation                                                              
|                                                                                          |  |                                                                                                     
|                                                                                          |  | By:                                                                                                 
|                                                                                          |  | Name:                                                                                               
|                                                                                          |  | Title:                                                                                              
|                                                                                          |  |                                                                                                     
|                                                                                          |  | Address of Borrower:
2425 East Camelback Road, Suite 650
Phoenix, AZ 85016
Attention: Ronald H. Lane
|                                                                                          |  |                                                                                                     
|                                                                                          |  |                                                                                                     
|                                                                                          |  | "Agent"                                                                                             
|                                                                                          |  |                                                                                                     
|                                                                                          |  | William McCormick                                                                                   
|                                                                                          |  |                                                                                                     
|                                                                                          |  | /s/WILLIAM MCCORMICK                                                                                
|                                                                                          |  |                                                                                                     
|                                                                                          |  | Address of Agent:
c/o Inverness
660 Steamboat Road
Greenwich, CT 06830                              
|                                                                                          |  |                                                                                                     
|                                                                                          |  |                                                                                                     
|ACKNOWLEDGEMENT OF LENDERSThe Lenders hereby agree to be bound by the terms of this Note.
|                                                                                          |  |                                                                                                     
|                                                                                          |  |                                                                                                     
|                                                                                          |  | "Lenders"                                                                                           
|                                                                                          |  |                                                                                                     
|                                                                                          |  | HEALTHSTAR HOLDINGS LLC, as a Lender                                                                
|                                                                                          |  |                                                                                                     
|                                                                                          |  | By:                                                                                                 
|                                                                                          |  | Name:                                                                                               
|                                                                                          |  | Title:                                                                                              
|                                                                                          |  |                                                                                                     

6

---

| |  | Address of HealthSTAR Holdings LLC:
100 Woodbridge Center Drive, Suite 202
Woodbridge, NJ 07095
| |  | -----------------------------------------------------------------------------------------------
| |  |                                                                                                
| |  |                                                                                                
| |  | William McCormick, as a Lender                                                                 
| |  |                                                                                                
| |  | /s/WILLIAM M. MCCORMICK                                                                        
| |  |                                                                                                
| |  | Address of William McCormick:
c/o Inverness
660 Steamboat Road
Greenwich, CT 06830             
| |  |                                                                                                
| |  | Xiagen Ltd., as a Lender                                                                       
| |  |                                                                                                
| |  | By:                                                                                            
| |  | Name:                                                                                          
| |  | Title:                                                                                         
| |  |                                                                                                
| |  | Address of Xiagen Ltd.:
c/o Inverness
660 Steamboat Road
Greenwich, CT 06830                   
| |  |                                                                                                
| |  |                                                                                                
| |  | Ropart Investments, LLC, as a Lender                                                           
| |  |                                                                                                
| |  | By:                                                                                            
| |  | Name:                                                                                          
| |  | Title:                                                                                         
| |  |                                                                                                
| |  | Address of Ropart Investments LLC:
One East Weaver Street
Greenwich, CT 06831                  
| |  |                                                                                                
| |  |                                                                                                
| |  | Frederick B. Rentschler, as a Lender                                                           
| |  |                                                                                                
| |  | /s/FREDERICK B. RENTSCHLER                                                                     
| |  |                                                                                                
| |  | Address of Frederick B. Rentschler:
P.O. Box 4710
Cave Creek, AZ 85327                         
| |  |                                                                                                
| |  |                                                                                                
| |  |                                                                                                
| |  |                                                                                                

7

---

| |  | Ronald H. Lane, as a Lender                                                    
| |  | -------------------------------------------------------------------------------
| |  |                                                                                
| |  | /s/RONALD H. LANE                                                              
| |  |                                                                                
| |  | Address of Ronald H. Lane:
2425 East Camelback Road
Suite 650
Phoenix, AZ 85016
| |  |                                                                                
| |  |                                                                                
| |  | William J. Ritger, as a Lender                                                 
| |  |                                                                                
| |  | /s/WILLIAM J. RITGER                                                           
| |  |                                                                                
| |  | Address of William J. Ritger
623 Ocean Ave.
Sea Girt, NJ 08750                 

8

---

QuickLinks