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USDA Agency and Company Partner to Explore Personal Care Products from Hemp Contact: Jan Suszkiw Email: Jan.Suszkiw@usda.gov April 27, 2021 Expanding the market for hemp seed oil is the goal of a new cooperative research and development agreement (CRADA) involving Agricultural Research Service (ARS) scientists and the Midwest Bioprocessing Center (MBC), a Peoria, Illinois-based firm specializing in organic chemical and pharmaceutical manufacturing. At the heart of the 24-month agreement is a patented process that a team of chemists with the ARS National Center for Agricultural Utilization Research (NCAUR) in Peoria developed, called “bio-catalysis.” In short, it involves using enzymes and heat rather than harsh chemicals and solvents to catalyze reactions that bind natural antioxidants like ferulic acid to lipids in soybean and other vegetable oils. In prior research, the team used the process to create a class of compounds called feruloyl soy glycerides (FSGs) from soybean oil. These were subsequently licensed and commercialized for use as ingredients in skin- and personal-care products because of the ultraviolet (UV) absorbance and antioxidant properties that they offered. Now, under the cooperative agreement with MBC, the team will explore creating similar ferulic-acid-based ingredients from bio-catalyzed hemp seed oil, potentially broadening the market for this commodity from an estimated 90,000 U.S. acres of industrial hemp, a type of *Cannabis sativa* that was legalized under the Farm Bill of 2018. Hemp seed oil today is popularly used in cannabidiol-containing products for perceived health benefits. However, like soy or corn oil, hemp oil also contains a variety of nutrients, fatty acids (including omega-3 fatty acids) and bioactive compounds that can be transformed into specialty chemicals offering useful new properties. Toward that end, the ARS-MBC team will focus on bio-catalyzing hemp oil to make “cosmeceuticals”—skin-care ingredients that perform specific functions, like protecting skin from UV light, retaining moisture, or stabilizing other active ingredients used in skin-care formulations. “Collaborating with industry partners like MBC, which has expertise in enzymology and the infrastructure for scale-up, is critical to exploring expanded uses for our original technology,” said Compton, with the ARS center’s Renewable Technologies Research Unit in Peoria. The research unit is one of seven comprising the NCAUR that collectively specialize in researching value-added uses for agricultural commodities as well as the byproducts of their manufacture into other processed goods. The NCAUR has also played a lead role in devising sustainable approaches to processing these commodities with an eye towards expanding economic opportunities for growers of both established crops like corn, wheat and soybean, as well as emerging ones, like cuphea and industrial hemp. In addition to opening the door to the cosmetics and personal care markets, NCAUR scientists are researching ways to better process hemp into fuels, lubricants and adhesives, as well as functional food ingredients and fiber products. *The Agricultural Research Service is the U.S. Department of Agriculture's chief scientific in-house research agency. Daily, ARS focuses on solutions to agricultural problems affecting America. Each dollar invested in agricultural research results in $17 of economic impact.*


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