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A Green Alternative For Treating *Streptococcus Iniae* Bacteria in Hybrid Striped Bass Contact: Jessica Ryan Email: Jessica.Ryan@usda.gov January 30, 2024 Scientists at the United States Department of Agriculture (USDA)’s Agricultural Research Service (ARS) developed a green antibiotic alternative to treat the deadly pathogen *Streptococcus iniae*in hybrid striped bass, the fourth most farmed finfish in the United States, according to a recent study. *S. iniae*is the causative agent of streptococcosis, a disease prevalent in aquaculture and causes a worldwide economic loss of $150 million annually. Disease outbreaks can bankrupt fish farms and put farmers at risk of getting the disease when handling infected fish. Current vaccines provide only short-term protection for *S. iniae*, and fish farmers more often rely on antibiotics to treat the disease. ARS scientists aimed to develop a natural treatment since antimicrobial resistance — a process when germs like bacteria and fungi develop the ability to fight drugs designed to kill them — is a major concern for aquaculture farmers when treating bacterial diseases. A hybrid striped bass on ice.Hybrid striped bass. (Photo by Matt McEntire, ARS) "Together with collaborators, we developed a novel antimicrobial protein and treatment regimen, that specifically kills only Streptococcus bacteria, and does not leave any chemical residues in the environment,” said Michael Deshotel, research microbiologist at the Harry K. Dupree Stuttgart National Aquaculture Research Center in Stuttgart, Arkansas. "According to our study’s results, this protein effectively cures *S. iniae*infectionsinhybrid striped bass." According to Deshotel, the protein, known as ClyX-2, showed a 95 percent survival rate for the fish in the treatment groups in comparison to the 5 percent survival rate of fish in the control groups during the study. The results showed that the protein was statistically as effective at treating *S. iniae*as antibiotic treatments like carbenicillin (85 percent cure rate). In the future, Deshotel and the researchers plan to study how to treat water to prevent diseases caused by *S. iniae*before they can infect fish. The recent study, published in *Fish & Shellfish Immunology*, was conducted in partnership with the USDA-ARS and Daniel Nelson from the University of Maryland’s Department of Veterinary Medicine. *The Agricultural Research Service is the U.S. Department of Agriculture's chief scientific in-house research agency. Daily, ARS focuses on solutions to agricultural problems affecting America. Each dollar invested in U.S. agricultural research results in $20 of economic impact.*


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