EX-10.27



 Exhibit 10.27 

FIRST AMENDMENT TO LEASE 

THIS FIRST AMENDMENT TO LEASE (this “Amendment”) is entered into as of this
30th day of April, 2013 (the “Execution Date”), by and between BMR-650 E KENDALL B LLC, a Delaware limited liability company (“Landlord”), and AVEO
PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). 
 RECITALS 

A. WHEREAS, Landlord and Tenant entered into that certain Lease dated as of May 9, 2012, as amended by that certain letter agreement
dated as of May 15, 2012 and that certain letter agreement dated as of February 15, 2013 (collectively, and as the same may have been further amended, amended and restated, supplemented or modified from time to time, the
“Lease”), whereby Tenant leases certain premises (the “Premises”) from Landlord on a portion of the fourth (4th) floor and the entire fifth (5th) and sixth (6th) floors, together with certain off-floor mechanical areas of the building located at 650 East Kendall Street,
Cambridge, Massachusetts (the “Building”); 
 B. WHEREAS, Landlord and Tenant desire to substitute existing off-floor
mechanical portions of the Premises for alternative off-floor mechanical locations; 
 C. WHEREAS, Landlord and Tenant, among other things,
desire to establish the square footage of Rentable Area of the Phase 1 Premises, to divide the Phase 2 Premises into Phase 2A Premises and Phase 2B Premises and to modify the Rentable Area of the Building and the Lab Building and Tenant’s Pro
Rata Share of the Building and the Lab Building; and 
 D. WHEREAS, Landlord and Tenant desire to modify and amend the Lease only in the
respects and on the conditions hereinafter stated. 
 AGREEMENT 

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 
 1. Definitions.
For purposes of this Amendment, capitalized terms shall have the meanings ascribed to them in the Lease unless otherwise defined herein. The Lease, as amended by this Amendment, is referred to herein as the “Amended Lease.” 

2. Premises and Premises Exhibit. Pursuant to Section 1.1(y) of the Lease, Tenant has requested and Landlord has agreed to
allow Tenant to substitute alternative, existing off-floor mechanical locations in the Building for the off-floor mechanical portions of the Premises that were initially depicted on Exhibit A attached to the Lease. Accordingly, Exhibit
A attached to the Lease is hereby deleted in its entirety and replaced with the revised Premises plans attached as Amended Exhibit A hereto. For the avoidance of doubt, such substitution of mechanical portions of the Premises has not
changed the overall Rentable Area of the Premises and the Premises still consists of one hundred twenty-six thousand sixty-five (126,065) square feet of Rentable Area. 

  
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 3. Phase 1 Premises Exhibit. A new exhibit depicting the Phase 1 Premises is hereby added
to the Lease as Exhibit B-3. A copy of Exhibit B-3 is attached hereto as New Exhibit B-3. 
 4. Phase 2A Premises
Exhibit. A new exhibit depicting the Phase 2A Premises is hereby added to the Lease as Exhibit M. A copy of Exhibit M is attached hereto as New Exhibit M. 

5. Rentable Areas and Tenant’s Pro Rata Shares. Effective January 1, 2013, Rentable Areas of the Building and the Lab
Building and Tenant’s Pro Rata Share of the Building and the Lab Building are hereby modified as follows, and the chart in Section 2.2 of the Lease is hereby deleted and replaced with the following two (2) charts: 

RENTABLE AREAS 
  

					
	 Definition or Provision
	  	Means the Following
(As of the Execution Date)	 
	 Rentable Area of Phase 1 Premises
	  	 	26,734	  
	 Rentable Area of Phase 2A Premises
	  	 	5,028	* 
	 Rentable Area of Phase 2B Premises
	  	 	94,303	* 
	 Rentable Area of Phase 2 Premises
	  	 	99,331	  
	 Rentable Area of Premises
	  	 	126,065	  
	 Rentable Area of Building
	  	 	282,217 square feet	  
	 Rentable Area of Lab Building
	  	 	269,260 square feet	  

  

	*	Note: The measurement standard used to determine the Rentable Area for each of the Phase 2A Premises (5,028 square feet) and the Phase 2B Premises (94,303 square feet) is not the same measurement standard used
by Landlord to measure the overall Rentable Area for the Phase 2 Premises (99,331 square feet). 

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 PRO RATA SHARES 

													
	 Definition or Provision
	  	Means the
Following (As of
January 1, 2013)	 	  	Tenant’s
Pro Rata
Share of
Building	 	 	Tenant’s Pro
Rata Share of
Lab Building	 
	 Rentable Area of Phase 1 Premises
	  	 	26,734 square feet	  	  	 	9.47	% 	 	 	9.93	% 
	 Rentable Area of Phase 2A Premises
	  	 	5,028 square feet	* 	  	 	1.78	% 	 	 	1.87	% 
	 Rentable Area of Phase 2B Premises
	  	 	94,303 square feet	* 	  	 	33.42	% 	 	 	35.02	% 
	 Rentable Area of Phase 2 Premises (includes Phase 2A Premises and Phase 2B Premises)
	  	 	99,331 square feet	  	  	 	35.20	% 	 	 	36.89	% 
	 Rentable Area of Premises (includes Phase 1 Premises, Phase 2A Premises and Phase 2B Premises)
	  	 	126,065 square feet	  	  	 	44.67	% 	 	 	46.82	% 

  

	*	Note: The measurement standard used to determine the Rentable Area for each of the Phase 2A Premises (5,028 square feet) and the Phase 2B Premises (94,303 square feet) is not the same measurement standard used
by Landlord to measure the overall Rentable Area for the Phase 2 Premises (99,331 square feet). 

 6. Base Rent.

 (a) Section 2.3, including both the written text and chart, is hereby deleted in its entirety and replaced with the following:

 “2.3 Initial monthly and annual installments of Base Rent for the Premises (“Base Rent”) as of the Phase 1 Premises
Rent Commencement Date (as defined in Section 4.1 below), subject to adjustment under this Lease: 
  

																	
	 Dates
	  	Square Feet of
Rentable Area for the
Premises	 	  	Base Rent per
Square Foot of
Rentable Area of
the Premises	 	  	Monthly
Base Rent	 	  	Annual Base
Rent	 
	 January 1, 2013 – the date immediately preceding the Phase 2A Rent Commencement Date
	  	 	26,734 square feet	  	  	$	54.50 annually	  	  	$	121,416.92	  	  	$	1,457,003.00	* 
	 Phase 2A Rent Commencement Date – the date immediately preceding the Phase 2B Rent Commencement Date
	  	 	31,762 square feet	  	  	$	54.50 annually	  	  	$	144,252.42	  	  	$	1,731,029.00	* 
	 Phase 2B Rent Commencement Date – December 31, 2013
	  	 	126,065 square feet	  	  	$	54.50 annually	  	  	$	572,545.21	  	  	$	6,870,542.50	* 

  

	*	Calculated on a twelve (12) month period. 


  
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 As further described in Section 4.1, below, Base Rent shall only be payable with
respect to the Phase 1 Premises, until such time as the Phase 2A Premises Rent Commencement Date occurs, and then until such time as the Phase 2B Premises Rent Commencement Date occurs.” 

(b) The Address for Rent Payment, as set forth in Section 2.8 of the Lease, is amended to read as follows: 

 

			
	If by Check:		 BMR-650 E Kendall B LLC
 PO Box 511217

Los Angeles, CA 90051-3015

		
	 If by Wire Transfer:
		 Name of beneficiary: BMR-650 E Kendall B LLC

Account number: 153495105154
 Bank Name: US Bank

Routing/Transit #: 122235821
 Branch Name & Address: San
Diego Main
 600 W Broadway #100
 San Diego, CA
92101



 7. Possession and Commencement Date. Sections 4.1 and 4.3 of the Lease are hereby
deleted, each in its entirety, and replaced with the following: 
 “4.1 Landlord has delivered to Tenant, broom clean
and free of occupants, and Tenant has accepted possession of, the Premises as of the date hereof. Landlord represents and warrants to Tenant that, as of the date hereof, the heating, ventilation and air-conditioning (“HVAC”),
electrical, life safety and plumbing systems of the Building are in good working condition and, to the best of Landlord’s knowledge, not in violation of Applicable Laws applicable to office and laboratory use, generally. Tenant shall undertake
its Tenant Improvements and occupy the Premises for the conduct of its business in two (2) phases (with the second phase being subdivided into two (2) additional phases). The “Phase 1


  
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Premises” shall consist of twenty-six thousand seven hundred thirty-four (26,734) square feet of Rentable Area on the sixth (6th) floor of the Building. The “Phase 2
Premises” shall consist of a total of ninety-nine thousand three hundred thirty-one (99,331) square feet of Rentable Area on the fourth (4th) floor, fifth (5th) and sixth (6th) floors, and shall be subdivided into (a) the “Phase 2A Premises” consisting of five thousand
twenty-eight (5,028) square feet of Rentable Area and (b) the “Phase 2B Premises” consisting of ninety-four thousand three hundred three (94,303) square feet of Rentable Area. The Rent Commencement Date shall be
determined separately for each Phase and Base Rent shall be calculated based on the ratio of square footage of the Phase 1 Premises to the entire Premises, and then the square footage of the Phase 1 Premises plus the Phase 2A Premises to the entire
Premises, until such time as the “Rent Commencement Date” occurs with respect to the entire Premises (i.e., until such time as the Phase 2B Premises Rent Commencement Date occurs). The parties agree that the “Phase 1
Premises Rent Commencement Date” is January 1, 2013. The “Phase 2A Premises Rent Commencement Date” shall be the earlier of (m) the Date that is the earlier to occur of (i) Substantial Completion of the work
described on Exhibit B with respect to the Phase 2A Premises (the “Phase 2A Premises Tenant Improvements”), and (ii) August 1, 2013 and (n) the date on which Tenant (or a subtenant) has occupied any portion of the
Phase 2A Premises for the conduct of its business, as opposed to occupying any portion of the Phase 2A Premises for the installation of the Tenant Improvements (as defined below). The “Phase 2B Premises Rent Commencement Date” shall
be the earlier of (y) the Date that is the earlier to occur of (i) Substantial Completion of the work described on Exhibit B with respect to the Phase 2B Premises (the “Phase 2B Premises Tenant Improvements” and,
together with the Phase 1 Premises Tenant Improvements, and the Phase 2A Premises Tenant Improvements, the “Tenant Improvements”), and (ii) November 1, 2013 and (z) the date on which Tenant has occupied any portion of
the Phase 2B Premises for the conduct of its business, as opposed to occupying any portion of the Phase 2B Premises for the installation of the Tenant Improvements. Each of the Phase 1 Premises Rent Commencement Date, the Phase 2A Premises Rent
Commencement Date and the Phase 2B Premises Rent Commencement Date shall be subject to extension for Landlord Delay as further described in Section 4 of Exhibit B hereto. Each party shall execute and deliver to the other written
acknowledgment of the actual Commencement Date, the actual Phase 1 Premises Rent Commencement Date, the actual Phase 2A Premises Rent Commencement Date, the actual Phase 2B Premises Rent Commencement Date and/or the Term Expiration Date within ten
(10) business days after request by the other party, substantially in the form attached as Exhibit C hereto. Failure to execute and deliver such acknowledgment, however, shall not affect the Phase 1 Premises Rent Commencement Date, the
Phase 2A Premises Rent Commencement Date, the Phase 2B Premises Rent Commencement Date, the Term Expiration Date or Landlord’s or Tenant’s liability hereunder. The term “Substantially Complete” or “Substantial
Completion” means that the applicable 

  
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Phase of Tenant Improvements is substantially complete in accordance with the Approved Plans (as defined in Exhibit B hereto), except for minor punch list items, and that Tenant is able to
lawfully occupy the Premises for the conduct of its business in accordance with the Permitted Use.” 
 “4.3 The
Phase 1 Premises, the Phase 2A Premises and the Phase 2B Premises are sometimes generically referred to herein as a “Phase”.” 

8. Rentable Area. Subject to the revised Rentable Areas agreed to in this Amendment, the parties hereby affirm that
Section 6 of the Lease remains in effect, and that the Rentable Areas of the Lease set forth in this Amendment are deemed conclusive between the parties and are not subject to re-measurement. Landlord and Tenant expressly agree that, in
connection with any future additions of space to, or subtractions of space from, the Premises, the measurement standard used in calculating the space so added or subtracted will be the same standard as that used in arriving at the Rentable Area of
Premises, the Building and the Lab Building in Section 5 above; provided, however, that the parties acknowledge that the measurement standard used to determine the Rentable Area for each of the Phase 2A Premises and the Phase 2B
Premises is not the same measurement standard used by Landlord to measure the overall Rentable Area for the Phase 2 Premises. 
 9.
Rent. The second sentence of Section 7.3 of the Lease is hereby deleted in its entirety and replaced with the following: “In the event the Phase 1 Premises Rent Commencement Date, the Phase 2A Premises Rent Commencement Date
or Phase 2B Premises Rent Commencement Date occurs or the Term ends on a day other than the first day of a calendar month, then the Rent for such fraction of a month shall be prorated for such period on the basis of a thirty (30) day month and
shall be paid at the then-current rate for such fractional month. 
 10. Operating Expenses. Section 9.4 of the Lease is
hereby deleted in its entirety and replaced with the following: 
 “9.4 Tenant shall not be responsible for Operating
Expenses attributable to the time period prior to the Phase 1 Premises Rent Commencement Date, with respect to the Phase 1 Premises; the Phase 2A Premises Rent Commencement Date, with respect to the Phase 2A Premises; or the Phase 2B Premises Rent
Commencement Date, with respect to the Phase 2B Premises.” 
 11. Parking. The second sentence of Section 13.5(a) is
hereby deleted and replaced with the following: “Tenant has designated 27 of the 189 unreserved parking spaces allocable to the Phase 1 Premises as being licenses as of the Phase 1 Premises Rent Commencement Date, and 6 of the 189 unreserved
parking spaces allocable to the Phase 2A Premises as being licenses as of the Phase 2A Premises Rent Commencement Date (with the remainder of Tenant’s Parking Spaces being treated as allocable to the Phase 2B Premises).” 

  
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 12. Work Letter. 

(a) The last sentence of Section 1.2 of Exhibit B to the Lease is hereby deleted in its entirety and replaced with the following:
“Subject to the provisions of Section 41.6 of the Lease, if Tenant has not substantially completed the Tenant Improvements and obtained a certificate of occupancy for the applicable portion of the Premises suitable for the Permitted Use
(or Tenant is not otherwise able to lawfully occupy the applicable portion of the Premises, whether or not a certificate of occupancy has been issued) by the date that is six (6) months following the Phase 1 Premises Rent Commencement Date,
with respect to the Phase 1 Premises; six (6) months following the Phase 2A Premises Rent Commencement Date, with respect to the Phase 2A Premises; and eight (8) months following the Phase 2B Premises Rent Commencement Date, with respect
to Phase 2B Premises, then, as Landlord’s sole remedy hereunder, Landlord shall have the right to exercise its self-help remedy pursuant to Section 31.3 of the Lease in order to put the applicable portion of the Premises in such condition,
provided that Landlord shall (a) have no obligation to expend more than the TI Allowance unless Tenant provides Landlord with the necessary funds to cover any excess costs, (b) be entitled to a construction management fee of 3% of the cost
of such work (to be deducted from the TI Allowance) and (c) have the right to modify the Tenant Improvements as Landlord reasonably deems necessary to complete the same according to the Approved TI Plans and the available TI Allowance without
any additional costs incurred by Landlord or any obligation to Tenant to make such modified design work for Tenant’s particular use of the Premises.” 

(b) The first part of the second paragraph of Section 4 of Exhibit B to the Lease is hereby deleted in its entirety and replaced
with the following: “If Tenant shall be actually delayed in completing the Tenant Improvements for the Phase 1 Premises, the Phase 2A Premises or the Phase 2B Premises solely as a result of the occurrence of any of the following (a
“Landlord Delay”):” 
 (c) The last sentence of Section 7.2 of Exhibit B to the Lease is hereby deleted in
its entirety and replaced with the following: “The Approved TI Budget may be prepared and approved on a phased basis for the Phase 1 Premises, the Phase 2A Premises and the Phase 2B Premises.” 

(d) The second to last sentence of Section 7.3 of Exhibit B to the Lease is hereby deleted in its entirety and replaced with the
following: “The TI Allowance shall be allocated as reasonably determined by Landlord between the Phase 1 Premises, the Phase 2A Premises and the Phase 2B Premises based on their respective Rentable Areas.” 

13. Broker. Tenant represents and warrants that it has not dealt with any broker or agent in the negotiation for or the obtaining of
this Amendment, other than Richards Barry Joyce & Partners LLC (“Broker”), and agrees to indemnify, defend and hold Landlord harmless from any and all cost or liability for compensation claimed by any such broker or agent,
other than Broker, employed or engaged by it or claiming to have been employed or engaged by it. Broker is not entitled to a leasing commission in connection with the making of this Amendment. 

  
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 14. No Default. Tenant represents, warrants and covenants that, to the best of
Tenant’s knowledge, Landlord and Tenant are not in default of any of their respective obligations under the Lease and no event has occurred that, with the passage of time or the giving of notice (or both) would constitute a default by either
Landlord or Tenant thereunder. Landlord represents, warrants and covenants that, to the best of Landlord’s knowledge. Landlord and Tenant are not in default of any of their respective obligations under the Lease and no event has occurred that,
with the passage of time or the giving of notice (or both) would constitute a default by either Landlord or Tenant thereunder. 
 15.
Notices. Tenant confirms that, notwithstanding anything in the Lease to the contrary, notices delivered to Tenant pursuant to the Amended Lease should be sent to: 

AVEO Pharmaceuticals, Inc. 

650 East Kendall Street 

Cambridge, MA 02142 

Attn: Director, Facilities & Operations 

With copy to: 

AVEO Pharmaceuticals, Inc. 

650 East Kendall Street 

Cambridge, MA 02142 

Attn: General Counsel 

And with a copy to: 

Langer & McLaughlin, LLP 

855 Boylston Street 

Boston, MA 02113 

16. Effect of Amendment. Except as modified by this Amendment, the Lease and all the covenants, agreements, terms, provisions and
conditions thereof shall remain in full force and effect and are hereby ratified and affirmed. The covenants, agreements, terms, provisions and conditions contained in this Amendment shall bind and inure to the benefit of the parties hereto and
their respective successors and, except as otherwise provided in the Lease, their respective assigns. In the event of any conflict between the terms contained in this Amendment and the Lease, the terms herein contained shall supersede and control
the obligations and liabilities of the parties. From and after the date hereof, the term “Lease” as used in the Lease shall mean the Lease, as modified by this Amendment. 

17. Miscellaneous. This Amendment becomes effective only upon execution and delivery hereof by Landlord and Tenant. The captions of the
paragraphs and subparagraphs in this Amendment are inserted and included solely for convenience and shall not be considered or given any effect in construing the provisions hereof. All exhibits hereto are incorporated herein by reference. Submission
of this instrument for examination or signature by Tenant does not constitute a reservation of or option for a lease, and shall not be effective as a lease, lease amendment or otherwise until execution by and delivery to both Landlord and Tenant.


  
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 18. Counterparts. This Amendment may be executed in one or more counterparts, each of
which, when taken together, shall constitute one and the same document. 
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 IN WITNESS WHEREOF, Landlord and Tenant have executed this Amendment as a sealed Massachusetts instrument as of
the date and year first above written, and acknowledge that they possess the requisite authority to enter into this transaction and to execute this Amendment. 
  

			
	 LANDLORD:
  

BMR-650 E KENDALL B LLC,
 a Delaware limited liability
company

		
	By:  	 	/s/ William Kane
	Name: William Kane
	Title:    Vice President, Leasing & Development

  

			
	 TENANT:
  

AVEO PHARMACEUTICALS, INC.,
 a Delaware corporation

		
	By:  	 	/s/ David Johnston
	Name: David Johnston
	Title:   Chief Financial Officer








 AMENDED EXHIBIT A  

PREMISES 
 See
attached fifteen (15) pages. 

  
 A-1 








 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 NEW EXHIBIT B-3 

PHASE 1 PREMISES 
 See
attached fifteen (15) pages. 

  
 B-3-1 








 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 



 







 NEW EXHIBIT M 

PHASE 2A PREMISES 

See attached two (2) pages. 

  
 M-1