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ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Molecular Plant Pathology Laboratory Docs







Pospiviroids and Viroid/ Host interactionsheadline bar Our laboratory studies interactions between viroids their plant hosts, with the aim of designing strategies to control plant diseases. To do this, we employ site-directed mutagenesis, secondary-structure prediction, and various methods for studying RNA/protein interactions. Recently, we have identified interactions between *Potato spindle tuber viroid* (PSTVd) RNA and host protein kinases. The relationship between these interactions and the cascade of gene induction pathways leading to pathogenesis is under investigation. We have also used a *Potato Virus X*(PVX)-based virus vector to assist in the identification of nuclear targeting signals within the PSTVd molecule. /ARSUserFiles/80420560/pospiviroids_and_viroid.jpg Tomato (cv. Rutgers) infected with a severe strain of PSTVd (right). We use this system to study the relationship between*Potato spindle tuber viroid*structure and viroid function, including replication, movement into the nucleus, and pathogenesis. **abstract1abstract2**


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