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Scientists Evaluate Potential Human Cannabinol Exposure from Consuming Meat if Cattle is Fed Hempseed Cake Contact: Maribel AlonsoEmail: Maribel.Alonso@usda.gov April 12, 2023 Scientists from the USDA's Agricultural Research Service (ARS) and North Dakota State University (NDSU) recently found that when cattle were fed with the industrial hemp byproduct, hempseed cake, very low levels of Cannabis chemicals (cannabinoids) were retained in muscle, liver, kidney, and fat tissues. Currently, hempseed cake cannot legally be used in food animal rations because the magnitude of cannabinoid (Cannabidiol [CBD] and Tetrahydrocannabinol [THC]) residues remaining in edible animal tissues have not been characterized. To determine if hempseed cake could be safely used as a source of protein and fiber in cattle feed, a team of USDA-ARS and NDSU researchers, led by Research Physiologist David J. Smith, evaluated cannabinoid residues (CBD, THC) in edible tissues of cattle that were fed hempseed cake.  Scientists found that the concentrations of these chemical compounds in meat products contributed only a small fraction of the total amount global regulatory organizations consider safe for consumers. Products from Cannabis plants (hemp; *Cannabis sativa L.*) have been used for fiber, food (seeds and oil), and medicinal purposes for thousands of years. Although the plant contains over 80 naturally occurring compounds called cannabinoids, the best-known cannabinoids are CBD and THC which are biologically active. In the modern era, plant breeders have cultivated Cannabis plant varieties to produce high amounts of CBD and THC (used for recreational and medicinal purposes) and varieties used for fiber and oil seed production ("industrial hemp"), which contain relatively low CBD and THC concentrations. In the 2018 Farm Bill, Congress authorized the legal production of industrial hemp in the United States (U.S.) with the stipulation that industrial hemp would contain less than 0.3% THC on a dry-matter basis. The low percentage of THC differentiates hemp products from marijuana or medicinal *Cannabis*varieties, which may contain greater than 5% THC. As industrial hemp develops as an agricultural commodity in the U.S., companies are now producing hemp seed oil from cultivars with very low THC content (< 0.01%). However, producers of hemp seed oil are having difficulty finding a market for hempseed cake, a major byproduct formed during oil extraction from industrial hempseed. Hemp seed cake and cattle in a field.Hempseeds and hempseed cake. (Photos courtesy of USDA-ARS) Hempseed cake is highly nutritious. In fact, a study completed by NDSU, in partnership with USDA-ARS, shows that hempseed cake is a viable alternative feed source for cattle. In the study recently published in *Food Additives and Contaminants* led by Smith, groups of heifers were fed either a control diet or a diet containing 20% hempseed cake for 111 days. When the feeding period was completed, cannabinoid residues in the liver, kidney, skeletal muscle, and adipose tissue were measured in animals harvested 0, 1, 4, and 8 days after hempseed cake was removed from the diet to learn how quickly cannabinoids are cleared from tissues. The hempseed cake used in the study contained an average concentration of 1.3 ± 0.8 mg/kg of CBD and THC combined, which is 1/3000 of the legal threshold of 0.3% (3000 mg/kg) THC. Cannabinoid residues were sporadically detected in urine and plasma of cattle during the feeding period, and low levels (about 10 parts per billion) of CBD and THC combined were measured in adipose tissue (fat) of cattle harvested with no withdrawal period. In liver, kidney, and skeletal muscle, however, CBD and THC were below detectable levels in the cattle fed hempseed cake. "According to our exposure assessment, it would be very difficult for a human to consume enough fat from cattle fed with hempseed cake to exceed regulatory guidelines for dietary THC exposure," said, David Smith with the Animal Metabolism-Agricultural Chemicals Research Unit in Fargo, North Dakota. "From a food safety view point, hempseed cake having low cannabinoid content can be a suitable source of crude protein and fiber in cattle feed while offering industrial hemp producers a potential market for this byproduct of hempseed oil extraction," added Smith. Final determination and approval for the legal use of hemp products in animal feeds remain with the U.S. Food and Drug Administration. *The Agricultural Research Service is the U.S. Department of Agriculture's chief scientific in-house research agency. Daily, ARS focuses on solutions to agricultural problems affecting America. Each dollar invested in U.S. agricultural research results in $20 of economic impact.*


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