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                    U.S. DEPARTMENT OF AGRICULTURE
 Mycotoxin Prevention and Applied Microbiology Research: Peoria, IL
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ARS Home Midwest Area Peoria, Illinois National Center for Agricultural Utilization Research Mycotoxin Prevention and Applied Microbiology Research Docs





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What are Mycotoxins?headline bar Mycotoxins are toxins produced by molds (fungi) and can accumulate in crops, where they pose health hazards to humans and animals.  Mycotoxins are estimated to affect 25% of the world’s crops and cost US agriculture approximately $1 billion each year. **Mycotoxin groups** **Trichothecenes** **/ARSUserFiles/50100525/images/test-tich.jpg** Trichothecenes are produced by multiple fungi, but those produced by the fungus *Fusarium* are of greatest concern to human and animal health, because of the widespread occurrence of these toxins in cereal crops.  When some *Fusarium* species infect crops, such as barley, corn and wheat, they can produce trichothecenes in infected grain. If humans or animals eat trichothecene-contaminated grain, they can experience health problems, including vomiting, hemorrhaging in the digestive tract, nausea, diarrhea, and fever.  Within human and animal cells, trichothecenes inhibit formation of proteins.  Because proteins are required for virtually all essential physiological processes, it makes sense that trichothecenes can have numerous negative effects on human and animal health. The trichothecenes of greatest concern to US agriculture are: deoxynivalenol, diacetoxyscirpenol and T-2 toxin. /ARSUserFiles/50100525/images/trico.jpg  **Fumonisins** **/ARSUserFiles/50100525/images/corn-fb1-test.jpg       /ARSUserFiles/50100525/images/FumonisinB1.jpg** Fumonisins are also produced by multiple fungi, but production by the fungus *Fusarium*is of greatest concern to human and animal health.  Fumonisin contamination has been reported in multiple crops, including onion, rice and wheat, but contamination in corn is most significant in terms of impacts on health and agriculture.  Fumonisins can induce multiple fatal diseases in animals, including fluid in lungs of pigs, lesions in the brains of horses, as well as cancer and deformation of the brain, spine and spinal cord in experimental mice and rats.  There are also correlations between the consumption of fumonisin contaminated grain and cancer of the esophagus and deformation of the spinal cord is some human populations for which corn is a dietary staple. All these toxic effects of fumonisins are thought to result from the ability of the toxins to inhibit the formation of a class of fatty acid-derived metabolites known as sphingolipids.  In humans and animals, sphingolipids are required for many physiological processes. This is most likely the reason why fumonisins have so multiple toxic effects.  **Zearalenone** /ARSUserFiles/50100525/images/3wheat.jpg         /ARSUserFiles/50100525/images/Zearalenone.jpg Zearalenone is produced by multiple species of the fungus *Fusarium* and is found in cereal crops such as barley, corn, oats, rice, sorghum and wheat.  This mycotoxin interferes with the effects of the animal and human hormone estrogen. Zearalenone is particularly a problem in swine/pigs where it can cause infertility, miscarriages, and other problems with reproduction.  **Aflatoxins** **/ARSUserFiles/50100525/images/aspergilluscornkernel.jpg           /ARSUserFiles/50100525/images/AflatoxinB1.jpg** Aflatoxins are one of the most potent naturally-occurring carcinogens. These toxins are found as contaminants in multiple crops, including corn, peanuts, almonds and walnuts. They are produced by multiple species of the fungus *Aspergillus*, but production by *Aspergillus flavus*and *A. parasiticus*is of greatest concern. When animals eat aflatoxin contaminated feed they can become sick, and they can pass the toxins to eggs, milk and meat. MPM does research on methods for aflatoxin detection, but most aflatoxin research funded by the USDA is conducted at other locations, including Southern Regional Research Center in New Orleans, National Peanut Research Laboratory in Dawson, Georgia, and the Western Regional Research Center in Albany, California.


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