**Exhibit 4.(B)2**

RAPPAPORT,   ASERKOFF & GELLES AN ASSOCIATION INCLUDING A PROFESSIONAL CORPORATION 15   STATE STREET.SUITE 1410 BOSTON. MA 021<19·1827 JEROME LYLE RAPPAPORT, P.C.   JANET F. ASERKOFF EDWARD GELLES TELEPHONE 617-227·7345 FACSIMILE 617·227-1727   DANIEL B. RA KOV (1932·1982) September 30, 2015 Phenogen Sciences, Inc. Attn:   Brian Manuel, Chief Financial Officer 9115 Harris Corners Parkway, Suite 320   Charlotte, North Carolina 28269 Re: Fourth Amendment to Lease Agreement New   Boston Harris Corners LLC ("Landlord") Phenogen Sciences, Inc.   ("Tenant") 9115 Harris Corners Parkway, Charlotte, North Carolina   (the "Building") Dear Mr. Manuel: Enclosed is one (1) fully   executed original of the above-referenced document for your files. Very truly   yours, 13::( Karen B. Furman, ACP Advanced Certified Paralegal Enclosure cc:   Jon Gillman, New Boston Fund, Inc. (via e-maiij Paul Stuart, New Boston   Management Services, Inc. (via e-maiij 

 

\ [ ORIGINAL   FOURTH AMENDMENT TO LEASE AGREEMENT This Fourth Amendment to Lease Agreement   (this "Amendment") made as of this J day of September, 2015 between   NEW BOSTON HARRIS CORNERS LLC, a Delaware limited liability company with a   principal place of business at 75 State Street, Suite 1410, Boston, Massachusetts   02109 ("Landlord") and PHENOGEN SCIENCES, INC., a Delaware   corporation with a principal place of business at 9115 Harris Comers Parkway,   Charlotte, North Carolina 28269 ("Tenant"). WHEREAS, Landlord is   the owner of the building known as 9115 Harris Corners Parkway (a/k/a Two   Harris Comers), Charlotte, North Carolina (the "Building");   WHEREAS, pursuant to a Lease Agreement dated as of August 17, 2010 by and   between Landlord's predecessor in interest, HC 9115 LLC, and Tenant, as   amended by a First Amendment to Lease Agreement dated August 17, 2012, as   further amended by a Second Amendment to Lease Agreement dated as of October   11, 2013, and as further amended by a Third Amendment to Lease Agreement   dated as of October 24, 2014 by and between Landlord and Tenant (as so   amended, the "Lease") Tenant leases approximately 1,610 square feet   of net rentable area on the third floor of the Building (the   "Premises"); and WHEREAS, Landlord and Tenant desire to extend the   term of the Lease and to modify certain other provisions thereof; NOW,   THEREFORE, in consideration of the Lease, the mutual covenants therein and   hereinafter set forth and for other good and valuable consideration, the   receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant   agree as follows: 1. Terms. All capitalized terms used herein and not defined   herein shall have the meanings ascribed to such terms in the Lease. 2. Lease   Term. Notwithstanding anything to the contrary contained in the Lease, the   Lease Term shall be extended for an additional period of twelve (12) months   commencing on November 1, 2015 and expiring on October 31, 2016 (the   "Third Extended Term"). 3. Monthlv Base Rent. Tenant shall pay   Monthly Base Rent during the Third Extended Term as set forth below: Lease   Period November 1, 2015 - October 31, 2016 4. Other Agreements. (a) Security   Deposit. Landlord shall continue to hold the security deposit in -1-g:\   leases\ Harns Corners\ Phenogen \ phenogen 4th am nd vOl 

 

the amount of   $2,595.00 delivered by Tenant pursuant to the Lease, as security for the   payment of Tenant's obligations under the Lease. (b) Brokerage. Each of   Landlord and Tenant represents and warrants to the other that it has dealt   with no broker, other than Trinity Partners, in connection with this   Amendment, and agrees to indemnify, defend and hold harmless from and against   any loss, cost, claims, and expenses, including attorneys' fees, arising from   a breach of this representation. 5. (a) General Provisions. Liability. The   obligations contained herein on the part of Landlord are solely those of New   Boston Harris Comers LLC and no trustee, agent, employee, member,   beneficiary, partner, general or limited, shall have any liability on account   thereof. (b)Effect of Amendment. Except as modified herein, all terms and   conditions of the Lease remain in full force and effect and are hereby   ratified and confirmed. In the event the terms and conditions of this   Amendment conflict with the terms of the Lease, the terms and conditions of   this Amendment shall prevail and be controlling. From and after the   effectiveness of this Amendment, the term "this Lease" when used in   the Lease shall mean the Lease as modified by this Amendment. (c) Counterpart   Execution. This Amendment may be executed simultaneously in two or more   counterparts, each of which shall be deemed an original but all of which   shall constitute one and the same instrument. (d) Governing Law. This   Amendment shall be governed by and construed in accordance with the laws of   the State of North Carolina. (THE REMAINDER OF THIS PAGE HAS INTENTIONALLY   BEEN LEFT BLANK. SIGNATURES ARE CONTAINED ON THE FOLLOWING PAGE.J -2-g:\   leases\ Harris Corners\Phenogen \phenogen 4th amnd vOl 

 

IN WITNESS   WHEREOF, the parties hereto have caused this Amendment to be executed by   above written. their duly authorized representatives as of the day and year   first LANDLORD: NEW BOSTON HARRIS CORNERS LLC By: New Boston Fund, Inc., Its   Manager TENANT: PHENOGEN SCIENCES, INC. By: ...p-;;....· -­ M J.JU6L N Title:   C:.. b -3-g:\leases\Harris Corners\Phenogen \phenogen 4th amnd vOl