Exhibit 23

CONSENT OF INDEPENDENT REGISTERED PUBLIC
ACCOUNTING FIRM

We consent to
the incorporation by reference in the following Registration Statements:

| |     |                                                                                                                                                                                                                                 
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| | (1) | Registration
 Statement (Form S-8 No. 333-149445) pertaining to the MAKO Surgical Corp.
 2008 Omnibus Incentive Plan, MAKO Surgical Corp. 2008 Employee Stock Purchase
 Plan, and MAKO Surgical Corp. 2004 Stock Incentive Plan;
| |     |                                                                                                                                                                                                                                 
| | (2) | Registration
 Statement (Form S-8 No. 333-157888) pertaining to the MAKO Surgical Corp.
 2004 Stock Incentive Plan;                                                                                                             
| |     |                                                                                                                                                                                                                                 
| | (3) | Registration
 Statement (Form S-8 No. 333-157889) pertaining to the MAKO Surgical Corp.
 2008 Omnibus Incentive Plan;                                                                                                           
| |     |                                                                                                                                                                                                                                 
| | (4) | Registration
 Statement (Form S-8 No. 333-165386) pertaining to the MAKO Surgical Corp.
 2008 Omnibus Incentive Plan; and                                                                                                       
| |     |                                                                                                                                                                                                                                 
| | (5) | Registration
 Statement (Form S-3 No. 333-169464) of MAKO Surgical Corp.                                                                                                                                                        

of our reports
dated March 10, 2011, with respect to the financial statements of MAKO Surgical
Corp., and the effectiveness of internal control over financial reporting of MAKO
Surgical Corp., included in this Annual Report (Form 10-K) of MAKO Surgical
Corp. for the year ended December 31, 2010.

|                     |                             
|-------------------- | ----------------------------
|                     | /S/ERNST & YOUNG LLP        
|                     | Certified Public Accountants
|                     |                             
|Boca Raton,
 Florida |                             
|March 10,
 2011      |                             

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