Skip to main content
          Skip to FDA Search
          Skip to in this section menu
          Skip to footer links


U.S. flagAn official website of the United States government

					Here’s how you know
          			Dot gov**The .gov means it’s official.**Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
							      SSL**The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. 
			U.S. Food and Drug Administration
				
        Search
            Menu
							
						Search FDA
									
									Submit search 
		Featured
							Contact FDA
	                FDA Guidance Documents
	                Recalls, Market Withdrawals and Safety Alerts
	                Press Announcements
	                Warning Letters
	                Advisory Committees
	                En Español

					Products
            Food
							Drugs
							Medical Devices
							Radiation-Emitting Products
							Vaccines, Blood, and Biologics
							Animal and Veterinary
							Cosmetics
							Tobacco ProductsTopics
            About FDA
							Combination Products
							Regulatory Information
							Safety
							Emergency Preparedness
							International Programs
							News and Events
							Training and Continuing Education
							Inspections and Compliance
							Science and ResearchInformation For
            Consumers
	            Patients
	            Industry
	            Health Professionals
	            Federal, State and Local Officials 
 In this section:

                Licensing and Collaboration Opportunities

Licensing and Collaboration Opportunities

                        FDA Technologies Available for Licensing and Collaboration
          Recently Issued U.S. Patents to FDA
          The FDA Licensing Process
          Types of Licenses Home
          Science & Research
          FDA Technology Transfer Program
          Licensing and Collaboration Opportunities
          Recently Issued U.S. Patents to FDALicensing and Collaboration Opportunities Recently Issued U.S. Patents to FDA
  
  	
    Share
    Post
    Linkedin

    Email
    PrintThe following is a listing of U.S. Patents that were recently issued to FDA. These patents illustrate FDA’s commitment to protecting and advancing public health by helping to speed innovations that provide our nation with safe and effective medical products and that keep our food safe. These inventions are available for licensing. Please contact the **Technology Transfer Program office**. A complete listing of all FDA technologies that are available for licensing and collaboration is found **here**.

**By Year**

**2020****2019****2018****2017****201620152014****2013**

**2020**

United States patent **10,744,193**was issued on August 18, 2020, for Immunogenic RSV polypeptides.**FDA inventors**: Surender Khurana, Hana Golding.

United States patent **10,712,545**was issued on July 14, 2020 for Systems and methods for conducting contact-free thickness and refractive-index measurements of intraocular lenses using a self-calibrating dual confocal microscopy system.**FDA inventors**: Do-Hyun Kim, Ilko Ilev, Robert James, Don Calogero.

United States patent **10,604,783**was issued on March 31, 2020 for Vibrio assay methods and kits.**FDA inventors**: Tae Jo Ki, Jessica Jones, Angelo DePaola.

**2019**

United States patent **10,379,234**was issued on August 13, 2019 for Portable real time in-situ gamma-ray analysis system.**FDA inventors**: Cong Wei, Kelly Garnick, Thomas Scott.

United States patent **10,302,528**was issued on May 28, 2019 for Confocal laser method and device for measurement of optical properties of toric intraocular lenses.**FDA inventors**: Ilko Ilev, Bennet Walker, Robert James.

United States patent **10,267,837** was issued on April 23, 2019 for Portable real time in-situ gamma-ray analysis system.**FDA inventors**: Howard Bassen, Gonzalo Mendoza, Amir Razjouyan, Mohammad Eslami, Negin Shahshahan.

United States patent **10,214,732** was issued on February 26, 2019 for Lysin agent and method of use for diagnostic testing.**FDA inventors**: Segaran Pillai, Linda Weigel, Bernard Quigley, David R. Hodge.

**2018**

United States patent **10,160,957** was issued on December 25, 2018 for Development of dengue virus vaccine components.**FDA inventors**: Stephen S. Whitehead, Joseph E. Blaney, Brian R. Murphy, Ching-Juh Lai.

United States patent **10,118,948** was issued on November 6, 2018 for Antimicrobial peptides, pharmaceutical compositions, and methods of use thereof.**FDA inventors**: Jie Zheng, Ann Marie Knolhoff, Eric Wayne Brown, Timothy Ray Croley.

United States patent **10,076,535** was issued on September 18, 2018 for Use of CPG oligonucleotides co-formulated with an antibiotic to accelerate wound healing.**FDA inventors**: Dennis M. Klinman, Hiroyasu Ito.

United States patent **10,007,920** was issued on June 26, 2018 for Device and method for detection of counterfeit pharmaceuticals and/or drug packaging.**FDA inventors**: Nicola Ranieri, Mark Wilkowsjko, Michael Green.

United States patent **9,956,278** was issued on May 1, 2018 for Multivalent meningococcal conjugates and methods for preparing conjugates.**FDA inventors**: Che-Hung Robert Lee.

**2017**

United States patent **RE46,641** was issued on December 19, 2017 for Dengue tetravalent vaccine containing a common 30 nucleotide deletion in the 3'-UTR of dengue types 1,2,3, and 4, or antigenic chimeric dengue viruses 1,2,3, and 4.**FDA inventors**: Stephen S. Whitehead, Brian R. Murphy, Lewis Markoff, Barry Falgout, Joseph E. Blaney, Kathryn A. Hanley, Ching-Juh Lai.

United States patent **RE46,631** was issued on December 12, 2017 for Dengue tetravalent vaccine containing a common 30 nucleotide deletion in the 3'-UTR of dengue types 1,2,3, and 4, or antigenic chimeric dengue viruses 1,2,3, and 4.**FDA inventors**: Stephen S. Whitehead, Brian R. Murphy, Lewis Markoff, Barry Falgout, Joseph E. Blaney, Kathryn A. Hanley, Ching-Juh Lai.

United States patent **9,782,399** was issued on October 10, 2017 for Pharmaceutical compositions which inhibit FKBP52-mediated regulation of androgen receptor function and methods of using same.**FDA inventors**: Leonard M. Neckers, Marc B. Cox, Jane B. Neckers, Yeong Sang Kim, Aki Iwai, Yangmin Ning, Johanny Kugelman-Tonos, Heather A. Balsiger, Robert Fletterick.

United States patent **9,783,787** was issued on October 10, 2017 for Dengue tetravalent vaccine containing a common 30 nucleotide deletion in the 3'-UTR of dengue types 1,2,3, and 4, or antigenic chimeric dengue viruses 1,2,3, and 4.**FDA inventors**: Stephen S. Whitehead, Brian R. Murphy, Lewis Markoff, Barry Falgout, Joseph E. Blaney, Kathryn A. Hanley, Ching-Juh Lai.

United States patent **9,707,287** was issued on July 18, 2017 for Attenuated mutant dengue viruses comprising a mutation in the NS4B non-structural protein.**FDA inventors**: Stephen S. Whitehead, Brian R. Murphy, Kathryn A. Hanley, Joseph E. Blaney, Ching-Juh Lai.

**2016**

United States patent **9,486,518**was issued on November 8, 2016, for Membrane proximal region of HIV GP41 anchored to the lipid layer of a virus-like particle vaccine.**FDA inventors**: Ira Berkower.

United States patent **9,474,795**was issued on October 25,2016, for Polysaccharide-protein conjugate vaccines.**FDA inventors**: Che-Hung Robert Lee, Carl E. Frasch.

United States patent **9,427,476**was issued on August 30, 2016, for Multivalent meningococcal conjugates and methods for preparing conjugates.**FDA inventors**: Che-Hung Robert Lee, Valerian B. Pinto.

United States patent **9,409,956**was issued on August 9, 2016, for Salmonella typhi Ty21a expressing Yersinia pestis F1-V fusion protein and uses thereof.**FDA inventors**: Dennis J. Kopecko, Manuel Osorio, Monica R. Foote.

United States patent **9,402,889**was issued on August 2, 2016, for Live, oral vaccine for protection against Shigella dysenteriae serotype 1.**FDA inventors**: Dennis J. Kopecko, De-Qi Xu.

United States patent **9,399,672******was issued on July 26, 2016, for Hepatitis C virus neutralizing antibody.**FDA inventors**: Hongying Duan, Stephen M. Feinstone, Marian Major, Pei Zhang.

United States patent **RE46,042**was issued on June 28, 2016, for Development of dengue virus vaccine components.**FDA inventors**: Stephen S. Whitehead, Joseph E. Blaney, Brian R. Murphy, Ching-Juh Lai.

United States patent **10,377,798** was issued on June 1, 2016, for Recombinant respiratory syncytial virus G protein fragments.**FDA inventors**: Surender Khurana, Hana Golding.

United States patent **9,347,951**was issued on May 24, 2016, for Fusion protein comprising the extracellular domain of a filovirus glycoprotein fused to an immunoglobulin heavy chain constant region.**FDA inventors**: Gerardo Kaplan, Krishnamurthy Konduru, Jerome Jacques, Sina Bavari, Steven Bradfute.

United States patent **9,333,251**was issued on May 10, 2016, for Vaccine for protection against Shigella sonnei disease.**FDA inventors**: Dennis J. Kopecko, De-Qi Xu, John O. Cisar.

United States patent **9,328,391**was issued on May 3, 2016, for Cloning and expression of HIV-1 DNA.**FDA inventors**: Nancy T. Chang, Robert C. Gallo, Flossie Wong-Staal.

United States patent **9,309,574**was issued on April 12, 2016, for Molecular cloning of HIV-1 from immortalized cell lines.**FDA inventors**: Robert C. Gallo, Flossie Wong-Staal, Mikulas Popovic, Beatrice H. Hahn, George M. Shaw, Amanda G. Fisher.

United States patent **9,284,343******was issued on march 15, 2016, for 2'-O-aminooxymethyl nucleoside derivatives for use in the synthesis and modification of nucleosides, nucleotides and oligonucleotides.**FDA inventors**: Serge L. Beaucage, Jacek Cieslak.

United States patent **9,279,770** was issued on March 8, 2016, for Mid-infrared imaging of microarrays.**FDA inventors**: Magdi M. Mossoba, Sufian Al-Khaldi, Brianna Schoen, Betsy Jean Yakes.

United States patent **9,266,928** was issued on February 23, 2016, for Deletion of the beta 20-21 loop in HIV GP120 exposes the CD4 binding site for improved antibody binding.**FDA inventors**: Ira Berkower.

United States patent **9,243,036**was issued on January 26, 2016, for Antimicrobial activity of synthetic peptides.**FDA inventors**: Chintamani Atreya, Shilpakala Sainath Rao, Krishna Mohan V. Ketha.

United States patent **9,233,973**was issued on January 12, 2016, for Pharmaceutical compositions which inhibit FKBP52-mediated regulation of androgen receptor function and methods of using same.**FDA inventor**: Leonard M. Neckers, Marc B. Cox, Jane B. Neckers, Yeong Sang Kim, Aki Iwai, Yangmin Ning, Johanny Kugelman-Tonos, Heather A. Balsiger, Robert Fletterick.

**2015**
United States patent **9,205,276**was issued on December 8, 2015, for Light as a replacement for mitogenic factors in progenitor cells.**FDA inventors**: Ilko K. Ilev, Ronald W. Waynant.

United States patent **9,198,976**was issued on December 1, 2015, for Polysaccharide-protein conjugate vaccines.**FDA inventors**: Che-Hung Robert Lee, Carl E. Frasch.

United States patent **9,193,995**was issued on November 24, 2015, for Compositions for detecting human interferon-alpha subtypes and methods of use.**FDA inventors**: Ronald Rabin, Viraj Pramod Mane.

United States patent **9,194,868**was issued on November 24, 2015, for Flow cytometry-based systems and methods for detecting microbes.**FDA inventors**: Dan A. Buzatu, Jon G. Wilkes, Ted A. Moskal, Bill Nevius, Jason T. Taylor, Randal K. Tucker, Melinda Miller, Shawn Ramsanoop.

United States patent **9,181,306**was issued on November 10, 2015, for Insertion of foreign genes in Rubella virus and their stable expression in a live, attenuated viral vaccine.**FDA inventors**: Ira Berkower, Angela Spadaccini.

United States patent **9,175,033**was issued on November 3, 2015, for Methods for preparing complex multivalent immunogenic conjugates.**FDA inventors**: Che-Hung Robert Lee.

United States patent **9,163,068**was issued on October 20, 2015, for Influenza virus recombinant proteins.**FDA inventors**: Surender Khurana, Hana Golding.
United States patent **9,163,244**was issued on October 20, 2015, for Suppressors of CpG oligonucleotides and methods of use.**FDA inventors**: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi.

United States patent **8,557,250**was issued on October 15, 2015, for Methods for preparing complex multivalent immunogenic conjugates.**FDA inventor**: Che-Hung Robert Lee.

United States patent **9,121,855**was issued on September 1, 2015, for Methods for detection of HIV-1 antibodies utilizing a peptide containing a novel GP41 epitope.**FDA inventors**: Hana Golding, Surender Khurana.

United States patent **9,103,788**was issued on August 11, 2015, for Detection of bacterial contamination in a sample.**FDA inventors**: Jon G. Wilkes, Dan A. Buzatu, Randal K. Tucker.

United States patent **9,090,873**was issued on July 28, 2015, for Development of dengue virus vaccine components.**FDA inventors**: Stephen S. Whitehead, Joseph E. Blaney, Brian R. Murphy, Ching-Juh Lai.

United States patent **9,075,796**was issued on July 28, 2015, for Text mining for large medical text datasets and corresponding medical text classification using informative feature selection.**FDA inventors**: arianthi Markatou, Robert Ball, Taxiarchis Botsis, Michael D. Nguyen, Emily J. Wo.

United States patent **9,005,631**was issued on April 14, 2015, for Membrane proximal region of HIV GP41 anchored to the lipid layer of a virus-like particle vaccine.**FDA inventor**: Ira Berkower.

United States patent **9,006,203**was issued on April 14, 2015, for Method of reducing inflammatory infiltration in subjects with inflammatory lung disease.**FDA inventors**: Dennis M. Klinman, Hiroshi Yamada.

United States patent **8,992,943**was issued on March 31, 2015, for Vaccine for protection against Shigella sonnei disease.**FDA inventors**: Dennis J. Kopecko, De-Qi Xu, John O. Cisar.

United States patent **8,980,546**was issued on March 17, 2015, for Method for the detection of HIV-1-specific antibodies utilizing a VPU polypeptide.**FDA Inventors**: Hana Golding, Surender Khurana.

United States patent **8,968,719**was issued on March 3, 2015, for Live, oral vaccine for protection against Shigella dysenteriae serotype 1.**FDA inventors**: Dennis J. Kopecko, De-Qi Xu.

**2014**
United States patent **8,880,354**was issued on November 4, 2014, for System for magnetic resonance spectroscopy of brain tissue for pattern-based diagnostics.**FDA inventors**: Jon Wilkes, Dan A. Buzatu, Pierre Alusta, Bruce A. Pearce, Ryan M. Kretzer, Inessa Im, Richard Beger.

United States patent **8,877,213**was issued on November 4, 2014, for Live attenuated Leishmania vaccines.**FDA inventors**: Hira L. Nakhasi, Angamuthu Selvapandiyan, Alain Debrabant, Robert C. Duncan.

United States patent **8,859,207**was issued on October 14, 2014, for Live, oral vaccine for protection against Shigella dysenteriae serotype 1.**FDA inventors**: Leonard M. Neckers, Marc B. Cox, Jane B. Neckers, Yeong Sang Kim, Aki Iwai, Yangmin Ning, Johanny Tonos de Leon, Heather Balsiger.

United States patent **RE45,123** was issued on September 9, 2014, for Recombinant attenuated dengue viruses comprising a deletion in the 3' untranslated region and additional attenuating mutations induced by chemical mutagenesis.**FDA inventors**: Stephen S. Whitehead, Brian R. Murphy, Kathryn A. Hanley, Joseph E. Blaney, Ching-Juh Lai.

United States patent **8,790,635**was issued on July 29, 2014, for Live, oral vaccine for protection against Shigella dysenteriae serotype 1.**FDA inventors**: Dennis J. Kopecko, De-Qi Xu.

United States patent **RE45,053** was issued on July 29, 2014, for Attenuated dengue virus comprising mutations in the NS3 gene.**FDA inventors**: Stephen S. Whitehead, Brian R. Murphy, Kathryn A. Hanley, Joseph E. Blaney, Ching-Juh Lai.

United States patent **8,785,609** was issued on July 22, 2014, for Cloning and expression of HTLV-III DNA.**FDA inventors**: Nancy T. Chang, Robert C. Gallo, Flossie Wong-Staal.

United States patent **RE45,016** was issued on July 15, 2014, for Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses.**FDA inventors**: Stephen S. Whitehead, Brian R. Murphy, Kathryn A. Hanley, Joseph E. Blaney, Ching-Juh Lai.

United States patent **8,778,847** was issued on July 15, 2014, for Immunogenic peptides of influenza virus.**FDA inventors**: Hana Golding, Surender Khurana.

United States patent **8,753,649**was issued on June 17, 2014, for Polysaccharide-protein conjugate vaccines.**FDA inventors**: Che-Hung Robert Lee, Carl E. Frasch.

United States patent **8,741,869**was issued on June 3, 2014, for Oligonucleotides and its use to induce an immune response.**FDA inventors**: Dennis M. Klinman, Ken J. Ishii, Daniela Verthelyi.

United States patent **8,722,324**was issued on May 13, 2014, for Methods for detection of HIV-1-specific antibodies employing GP41 polypeptides.**FDA inventors**: Hana Golding, Surender Khurana.

United States patent **8,709,813**was issued on April 29, 2014, for DNA promoters and anthrax vaccines.**FDA inventors**: Dennis J. Kopecko, Chandrakant P. Giri.

United States patent **8,704,169**was issued in April 22, 2014, for Direct impact ionization (DII) mass spectrometry.**FDA inventors**: Pierre Alusta, Cameron Dorey, William Ryan Parker, Jon G. Wilkes, Dan Buzatu.

United States patent **8,680,065**was issued on March 25, 2014, for Oligonucleotides of human endogenous retrovirus 9 (ERV-9) long terminal repeat (LTR) and methods of use.**FDA inventors**: Lai Xu; Amy S. Rosenberg, Abdel Elkahloun, Fabio Candotti.

United States patent **8,652,801**was issued on February 18, 2014, for Hydrophilic IR transparent membrane, spectroscopic sample holder comprising same and method of using same.**FDA inventors**: Magdi Mossoba, Sufian Al-K.

United States patent **8****,632,782**was issued on January 21, 2014, for Recombinant attenuated dengue viruses comprising mutations in NS5 and the 3' untranslated region.**FDA inventors**: Stephen S. Whitehead, Brian R. Murphy, Kathryn A. Hanley, Joseph E. Blaney, Ching-Juh Lai.

United States patent **8,628,782**was issued on January 14, 2014, for Deletion of the beta 20-21 loop in HIV gp120 exposes the CD4 binding site for improved antibody binding and antibody induction.**FDA inventors**: Ira Berkower.

**2013**
United States patent **8,603,468**was issued on December 10, 2013, for Neutralization of HCV.**FDA inventors**: Pei Zhang, Marian Major, Stephen Feinstone.

United States patent **8,580,944**was issued on November 12, 2013, for Suppressors of CpG oligonucleotides and methods of use.**FDA inventors**: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi.

United States patent **8,574,844**was issued on November 5, 2013, for Quantitative real-time assay for noroviruses and enteroviruses with built in quality control standard.**FDA inventors**: William Burkhardt, III., Michael C. L. Vickery, Jessica Nordstrom.

United States patent **8,557,250**was issued on October 15, 2013, for Methods for preparing complex multivalent immunogenic conjugates.**FDA Inventor**: Che-Hung Robert Lee.

United States patent **8,557,789**was issued on October 15, 2013, for Method of treating inflammatory anthropathies with suppressors of CpG oligonucleotides.**FDA inventors**: Dennis M. Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel.

United States patent **8,501,188**was issued on August 6, 2013, for Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides.**FDA inventors**: Dennis M. Klinman, Hiroshi Yamada.

United States patent **8,481,055******was issued on July 9, 2013, for Method preventing infections from bioterrorism agents with immunostimulatory CpG oligonucleotides.**FDA inventors**: Dennis M. Klinman, Bruce Ivins, Daniela Verthelyi.

United States patent **8,470,342**was issued on June 25, 2013, for Methods of altering an immune response induced by CpG oligodeoxynucleotides.**FDA inventors**: Dennis M. Klinman, Mayda Gursel, Ihsan Gursel.

United States patent **8,465,749**was issued on June 18, 2013, for Polysaccharide-protein conjugate vaccines.**FDA inventors**: Che-Hung Robert Lee, Carl E. Frasch.

United States patent **8,456,738**was issued on June 4, 2013, for Ultrahigh-resolution fiber-optic confocal microscope and method.**FDA inventors**: Ilko K. Ilev, Ronald W. Waynant, Israel Gannot, Amir H. Gandjbakhche.

United States patent **8,389,495**was issued on March 5, 2013, for Oligonucleotides and its use to induce an immune response.**FDA inventors**: Dennis M. Klinman, Ken Ishii, Daniela Verthelyi.

United States patent **8,383,359**was issued on February 26, 2013, for Use of lymphocytes to measure anthrax lethal toxin activity.**FDA inventors**: David M. Frucht, Hui Fang.

                                                                                  Content current as of:
      01/15/2021Licensing and Collaboration Opportunities

          
                        FDA Technologies Available for Licensing and Collaboration
          Recently Issued U.S. Patents to FDA
          The FDA Licensing Process
          Types of Licenses
 
 Footer Links
    FDA Archive
          About FDA
          Accessibility
      Visitor Information
          Website Policies / Privacy
          No FEAR Act
          Vulnerability Disclosure Policy
      FOIA
          HHS.gov
          USA.gov
    Contact FDA
      Follow FDA on Facebook
      Follow FDA on X
      Follow FDA on Instagram
      Follow FDA on LinkedIn
      View FDA videos on YouTube
      Subscribe to FDA RSS feeds
    FDA Homepage
    Contact Number
      1-888-INFO-FDA (1-888-463-6332) Back toTop