| (1) | I                    have reviewed this quarterly report on Form 10-Q of PhotoMedex,                    Inc.; |
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| (2) | Based                    on my knowledge, this report does not contain any untrue statement                    of a                    material fact or omit to state a material fact necessary to make                    the                    statements made, in light of the circumstances under which such                    statements                    were made, not misleading with respect to the period covered                    by this                    report; |
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| (3) | Based                    on my knowledge, the financial statements, and other financial                    information                    included in this report, fairly present in all material respects                    the                    financial condition, results of operations and cash flows of                    the                    registrant as of, and for, the periods presented in this report; |
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| (4) | The                    registrant’s other certifying officer(s) and I are responsible for                    establishing and maintaining disclosure controls and procedures                    (as                    defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal                    control over financial reporting (as defined in Exchange Act                    Rules                    13a-15(f) and 15d-15(f)) for the registrant and have: |
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|  | (a) | designed                    such disclosure controls and procedures, or caused such disclosure                    controls and procedures to be designed under our supervision,                    to ensure                    that material information relating to the registrant, including                    its                    consolidated subsidiaries, is made known to us by others within                    those                    entities, particularly during the period in which this report                    is being                    prepared; |
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|  | (b) | designed                such internal control over financial reporting or caused such internal                control over financial reporting to be designed under our supervision,                to                provide reasonable assurance regarding the reliability of financial                reporting and the preparation of financial statements for external                purposes in accordance with generally accepted accounting                principles; |
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|  | (c) | evaluated                the effectiveness of the registrant’s disclosure controls and procedures                and presented in this report our conclusions about the effectiveness                of                the disclosure controls and procedures, as of the end of the period                covered by this report based on such evaluation; and |
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|  | (d) | disclosed                    in this report any change in the registrant’s internal control over                    financial reporting that occurred during the registrant’s most recent                    fiscal quarter (the registrant’s fourth fiscal quarter in the case of an                    annual report) that has materially affected, or is reasonably                    likely to                    materially affect, the registrant’s internal control over financial                    reporting; and |
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| (5) | The                    registrant's other certifying officer(s) and I have disclosed,                    based on                    our most recent evaluation of internal control over financial                    reporting,                    to the registrant's auditors and the audit committee of the registrant's                    board of directors (or persons performing the equivalent functions): |
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|  | (a) | all                    significant deficiencies and material weaknesses in the design                    or                    operation of internal control over financial reporting which                    are                    reasonably likely to adversely affect the registrant's ability                    to record,                    process, summarize and report financial information; and |
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|  | (b) | any                    fraud, whether or not material, that involves management or other                    employees who have a significant role in the registrant's internal                    control                    over financial reporting. |
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|                             |                                 |                                  |
|----------------------------------|--------------------------------------|---------------------------------------|
| Dated:              May 10, 2007 | By:                        | /s/              Jeffrey F. O'Donnell |
|                             | Jeffrey              F. O'Donnell    |
|                             | Chief              Executive Officer |

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