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			E #
			Product Area
			Research Area
			Technologies & Applications
			Development Stage
			FY
			KeywordsStable cell line for validating next-generation sequencing (NGS) methods for detecting adventitious viruses contaminating biological products
			E-2023-001
			Biologics testing and manufacturing including but not limited to viral vaccines, biotherapeutics, and cellular and gene therapy products
			Cell Line
			Therapeutics, Biologics
			In vitro data available
			2023
			A549, adventitious, assay, biological material, biologics, biologics testing, biotherapeutics, cell line, cellular therapeutics, gene therapy, latent virus, next-generation sequencing, NGS, reference standard, simian foamy virus, validation, viral vaccines, virusIdentification and elimination of helper and cytotoxic T cell epitopes in AAV9
			E-2022-010
			Gene Therapy, Immunology Research, Assay Development
			Gene Therapy, Diagnostic
			Gene Therapy, Research Tool, Diagnostic
			In vitro data available
			2022
			Helper T Cells, Cytotoxic T Cells, AAV9, Gene Therapy, Immunogenicity, AVV vectors, CD4, CD8, T Cells, Gene DeliveryLive attenuated Sars-CoV-2 vaccine candidate adaptable to emerging SARS-CoV-2 variants
			E-2022-007
			Vaccine development, candidate SARS-CoV-2 vaccine
			Vaccine Development
			Research Tool, Vaccine and Diagnostic Development
			Proof-of-concept, vaccine challenge studies in transgenic mice and in Syrian hamsters, and vaccine candidate
			2022
			COVID, COVID-19, Wang, live attenuated virus, Omicron, Delta, Wuhan-1, vaccine, vaccine development, SARS, SARS-CoV-2Computationally Engineered Anti-Sars-Cov-2 Monoclonal Antibodies with High Binding Affinities
			E-2022-006
			Research tools, diagnostic assays, vaccine development, therapeutic antibodies
			Vaccine Development, Diagnostics, Therapeutics
			Vaccine Development, Diagnostics, Therapeutics
			Monoclonal antibodies, expression plasmids, and in vitro characterization data
			2022
			SARS, SARS-CoV-2, SARS-CoV-1, monoclonal, antibodies, research tool, diagnostic, SaunaMagnetic Resonance Spectra (MRS) Processing Software for Accurate Analysis
			E-2022-005
			Software, medical diagnostic, research tool
			Medical Devices, Diagnostics
			Medical Devices, Diagnostics, MRI, MRS
			Proof-of-concept
			2022
			MRI, MRS, medical imaging, medical device, software, BuzatuModified Factor Xa Polypeptides to Recover Clotting Activity in Subjects Treated with Direct Oral Anticoagulants (DOACs)
			E-2022-003
			Biologics, Direct Acting Anticoagulants, DOACs, Thromboembolic Disease, Bleeding Disorders
			Therapeutics, Biologics
			Therapeutics, Biologics
			Proof-of-concept, In vivo animal data
			2022
			biologic, bleeding disorders, blood clots, clotting, direct oral anticoagulants, DOACs, factor Xa, Sauna, Thromboembolic DiseaseSystem and method for in vivo estimation of brain amyloid burden using X-rays
			E-2022-001
			Diagnostic imaging, neuroscience
			Medical Devices, Diagnostics
			Medical Devices, Diagnostics, Imaging
			prototype, proof of concept studies
			2022
			brain, amyloid plaque, X-rays, neurodegenerative disease, Alzheimer's, Parkinson's, PET, positron emission tomography, MRI, magnet resonance imagingLac operator-based mitigation of heterologous DNA instability in plasmids propagated in *E. coli*
			E-2021-019
			Therapeutics, vaccine, biologics
			Therapeutics, Bioprocessing
			Therapeutics, Biologics, Protein, Production, Bioprocessing
			In vitro data available
			2021
			Plasmid, DNA, Gene Expression, E. coli, biopharmaceutical, toxic gene, Lac Repressor, Influenza, Flu, Hemagglutinin, Neuraminidase, Reverse Genetics, viral protein, protein, vaccine, biologics, eukaryoticStable Non-infectious Cell Clones that Produce Functional SARS-CoV-2 RNA for Nonstructural Proteins and Accessory Proteins
			E-2021-017
			Screening Tool, COVID-19, SARS-CoV-2, Antiviral Drugs, Screening
			Viral Infectious Diseases
			SARS-CoV-2 replication, screening compounds
			Proof-of-concept for screening compounds, Research Tool
			2021
			Wang, Liu, SARS-CoV-2, COVID-19, cell clones, nonstructural proteins, accessory proteinsChimeric immunotoxins targeting IL-13Ralpha2 positive human cancers
			E-2021-010
			protein therapeutic, cancer, biologic, oncology
			Oncology
			protein therapeutic, cancer, biologic, oncology
			In vivo animal data
			2021
			IL-13, IL-13R, cancer, head and neck cancer, prostate cancer, colorectal cancer, breast cancer, stomach cancer, cervical cancer, oncology, protein, chimeric, Pancreatic ductal adenocarcinoma, PDACLive Attenuated Rubella Vector to Express Vaccine Antigens
			E-2012-003
			Research materials, tool, gene manipulation
			Vaccine Development
			Research Tool, HIV and Bivalent Rubella Vaccine Development
			Pre-clinical, in vitro data available, in vivo data available (animal)
			2012
			Berkower, Virmik, HIV, rubella, SIV, SHIV, P150, vaccine, antigenAdaptive Perfusion: A Novel In Vitro Release Test (IVRT) Method for Complex Drug Products
			E-2020-025
			drug development, drug formulations, drug manufacturing, drug production, quality control, drug delivery
			Drug development, drug manufacturing, quality control
			Drug development, drug manufacturing, quality control, tangential flow filtration (TFF)
			In vitro data, prototype
			2020
			Drug in vitro release testing, IVRT, drug dissolution testing, tangential flow filtration, formulation, drug development, quality control, emulsions, micelles, suspensions, liposomes, drug-protein complexChimeric antigen receptor (CAR)-T cells targeting IL-13Ralpha2 positive human solid cancers
			E-2020-020
			CAR-T, Cellular therapeutics, cancer, biologic, oncology, solid tumors
			CAR-T, Cellular therapeutics, cancer, biologic, oncology, solid tumors
			CAR-T, Cellular therapeutics, cancer, biologic, oncology, solid tumors
			In vivo animal data
			2020
			Chimeric antigen receptor T cell, CAR-T, cancer, solid tumors, cellular therapeutics, IL-13, IL-13RCoronavirus sars cov-2, sars cov antigens, and rabbit polyclonal antibodies
			E-2020-016
			Biologics
			Viral Infectious Diseases
			Vaccines
			Research Materials
			2020
			Antibody, rabbit, coronavirus, SARS, antigen, sera, vaccine development, KhuranaA Novel Solid Support for Efficient Reduction of Process-Related Impurities in Synthetic Nucleic Acid Sequences
			E-2020-015
			CPG support, nucleic acid-based drugs, solid-phase DNA/RNA synthesis
			Synthetic nucleic acid synthesis
			Purification of synthetic nucleic acid sequences
			Proof of concept system
			2020
			DNA, RNA, Beaucage, GrajkowskiMouse Monoclonal Antibodies Specific to Trypanosoma Cruzi Antigens
			E-2020-014
			Research materials, monoclonal antibodies, Trypanosoma cruzi, Chagas
			Chagas Disease
			Research Tool, Diagnostic Test for Chagas Disease, Antigen testing to confirm disease status
			Development assays to detect T. cruzi in mice and Chagas patients
			2020
			Chagas, T. cruzi, monoclonal antibodies, trypanosoma, Debrabant, Nagarkatti, AcostaHepg2-Fluc-Gluc and Hepg2-Fluc-Seap Cell Lines
			E-2020-010
			Research Materials, Cell Line, In Vitro System
			Cell line
			Drug evaluations for drug-induced liver injury
			Research Tool
			2020
			Cell Line, Liver Injury, Endoplasmic Reticulom, Gaussia Luciferase, Guo, ChenHybridomas for Monoclonal Antibodies Specific to Fragment B, Fragment C, and Light Chain of Tetanus Toxin
			E-2020-002
			Research Materials, Antibody, Vaccine
			Vaccine
			In-vitro diagnostics, tetanus toxin and fragments research and development
			Research Materials
			2020
			Tetanus, fragment C, antibodies, vaccine, tetani, Shapiro, Kenimer, Habig, Fitzsimmons, HardegreeCross-Protective Norovirus Epitope and Monoclonal Antibodies
			E-2019-025, E-2019-026
			antigenic variation, caliciviruses, evolution, gastrointestinal, infection, norovirus, phylogenetic, virus, antibodies, neutralizing, epitope, method, peptide, monotypic, interfere, sequence, amino acid, binding, inhibiting, gene, genomics
			Antiviral, virus, norovirus, diagnostic, assay development
			diagnostic, assay development
			In vitro data
			2019
			antigenic variation, caliciviruses, evolution, gastrointestinal, infection, norovirus, phylogenetic, virus, antibodies, neutralizing, epitope, method, peptide, monotypic, interfere, sequence, amino acid, binding, inhibiting, gene, genomicsLentiviral vectors bearing il-13 that Target Human IL-13 Receptor alpha-2-Positive TUMOR Cells
			E-2019-024
			Biologics
			Oncology, basic research, Lentivirals
			Bioassay, Diagnostics, Vaccine
			Research Materials
			2019
			Lentiviral vector, IL-13, IL-13RAn Attenuated Live Mumps Virus Vaccine Candidate Expressing F and HN Protein Genes from Genotype G
			E-2018-022
			Biologics
			Viral Infectious Disease
			Vaccines
			*In vivo*
			animal data
			2018
			mumps, vaccine, immunity, disease, meningitis, virus, plasmid, strains, Rubin, gene, Jeryl Lynn, protein, genotype, recombinant, combinationEfficient Storage Algorithm for Time-Domain Spectrum Measurement
			E-2018-016
			Algorithm, Software
			wireless signaling, data compression
			High-capacity storage of spectrum survey in a hospitals and healthcare systems
			Validated on National Instruments (NI) vector signal transceiver platform in a healthcare environment
			2018
			Bluetooth, frequency, wireless, signal, storage, hospital, medical, device, spectrum, time-domain, platform, method, interference, data compressionHybridomas Secreting Novel Monoclonal Antibodies Against the Nucleoprotein of Influenza Virus
			E-2018-007
			Biologics
			Viral Infectious Disease
			Bioassay, Diagnostics, Vaccine
			Research Material
			2018
			Influenza, Antibody, Vaccine, Diagnotic, Hongquan WanEnhanced Chemiluminescent Enzyme-Linked Immunosorbent Assay for Detection of Antibodies Against Babesia Microti
			E-2017-031
			Diagnostic, Screening Tool, Babesia microti
			Parasitic Infectious Diseases
			Babesia testing in donor blood
			Early development
			2017
			Kumar, Verma, Babesia, BabesiosisSynergistic Antitumor Activity of Combination Immunotherapy IL-4 receptor targeted agents and Interferons -alpha and -gamma
			E-2017-025
			Drugs, Oncology
			Oncology
			Biologic therapeutic
			in vivo animal studies
			2017
			IL-4, interferon, puri, synergistic, ovarian, cancer, chimeric protein, pseudomonas exotoxin, IFNgamma, anti-interleukin, anti-interleukin-4, Husain, GrSynergistic Antitumor Activity of Combination Immunotherapy IL-4 receptor targeted agents and Interferons -alpha and -gamma ​Reassortant Influenza Viruses Expressing Neuraminidase (NA) And A Mismatched Hemagglutinin (HA) Protein Useful for Determining Antibody Titers of Functional Na-Specific Antibodies
			E-2017-022
			Biologics
			Viral Infectious Diseases
			Vaccines, Diagnostics, Therapeutics
			In vitro data, Research Material
			2017
			Influenza, neuraminidase, HA, Hemagglutinin, virusListeria Monocytogene Strains Containing Antibiotic Resistance and Green-Flourescent Protein Markers
			E-2017-020
			Biologics
			Bacterial Infectious Diseases, Food Safety
			Vaccines, quality control, proficiency testing materials, test kits, Diagnostics, assay validation, Monitoring
			Research Material
			2017
			listeria, monocytogenes, pathogen, celery, contaminant, chicken, vaccine development, Datta, Sahu, BurallBiological Classifier and Clustering Methods for High-Dimensional, Multivariate Measurement Data Sets Using the Grand Canonical Monte Carlo Ensemble
			E-2017-017
			Bioinformatic, software, genomics
			Software, bioinformatics, genomics
			Software, bioinformatics, genomics
			Software
			2017
			Software, bioinformatics, genomics, Monte Carlo EnsembleSerum-Free Medium for the Isolation and Expansion of Canine Adipose-Derived Mesenchymal Stem/Stromal Cells
			E-2017-010
			Research material, Supplement, Media, Serum
			Stem cell, Stromal Cell
			In-vitro diagnostics, tetanus toxin and fragments research and development
			Research Material
			2017
			Mesenchymal Stem/Stromal Cells (MSCs), fetal bovine serum (FBS), Devireddy, ScrevenGonoccoccal Vaccine/Therapy from Neisseria meningitidis
			E-2017-006
			Biologics
			Viral infectious Diseases, bacterial infectious diseases
			Vaccines, Drug Design
			In vivo animal studies
			2017
			meningitis, meningitidis, Neisseria meningitidis, vaccine, N. meningitidis, N. gonorrhoeaeFactor H Binding Protein-Choleratoxin B Chimeric Vaccine Construct Against Neisseria Meningoccal Disease
			E-2017-003
			vaccine development, adjuvant
			Bacterial Infectious Diseases
			Vaccine development for group N. meningitidis serogroup B strains
			Early Proof of concept studies completed
			2017
			Neisseria Meningoccal, meningitidis, FHbp, choleratoxin, Bash, Price, LeeGenetically Engineered Mouse Model Used as an Alternative Screening Method for Evaluating P-Glycoprotein Substrate Toxicity in Avermectin-Sensitive Dogs
			E-2011-026
			Research materials, mouse model
			Drug Safety
			Drug screening technology to assess the toxicity of canine drugs to canines with the mutated form of the ABCB1 gene.
			In vitro data available
			2011
			Yancy, ABCB1, avermectin, Ivermectin, canine, herding dogsFlow Cytometry-Based Systems and Methods for Detecting Microbes
			E-2011-022
			Foodborne illnesses, food safety, flow cytometer, microbial contamination
			Foodborne illnesses, food safety, flow cytometer, microbial contamination
			Foodborne illnesses, food safety, flow cytometer, microbial contamination
			In vitro data, prototype
			2011
			foodborne illnesses, flow cytometry, microbial contamination, bacteria, virus, protozoa, prion, food safetyPooled Human Complement Meningococcal Bactericidal Activity Assay
			E-2014-008
			Method, immunoassay, vaccine development, assay development
			Vaccine
			Human bioassay development
			Proof-of-concept
			2014
			Bash, Lynn, meningococcal, serogroup AAnthrax Lethal Toxin Inhibits Proliferation of Human CD4+ t cells in Response to t cell Receptor Stimulation and Mitogen Stimulation
			Center
			E-2004-039
			anthrax bioassay, diagnostic, bioterrorism
			Viral Infectious Diseases
			Human bioassay development
			Early proof-of-concept
			2004
			Bacillus anthracis, anthrax, Frucht, Fang, bioterrorism, bioassayImproved Method of Allelic Exchange
			E-2015-003
			Research materials, tool, gene, manipulation
			Genetic alteration, allelic replacement
			Simplified genetic manipulation without use of selectable markers
			Research Materials
			2015
			Bordetella, Pertussis, parapertussis, bronchiseptica, Allelic, StibitzSoftware for 3D Spectral Fingerprint based consensus modeling using orthogonal pls and tanimoto similarity KNN techniques
			E-2014-001
			Software
			Molecular modeling, spectoral modeling
			Drug design, drug development, software, research tool
			
			2014
			Research tool, software, bioinformatics, modeling, Slavov, Berger, Buzatu, PearceInactivation of Pathogens in Blood Products Using Visible Light
			E-2014-013
			Antimicrobials, bacterial, infectious disease
			Blood pathogen reduction
			Blood Products, Pathogen Reduction, Infectious Disease, Antimicrobials
			prototype, proof of concept
			2014
			Antimicrobials, bacterial, infectious disease, blood products, pathogen reduction, Atreya, Maclean, Anderson, MacGregorAnti-Influenza A Neuraminidase monoclonal antibodies
			E-2015-001, E-2013-008, E-2019-012
			Animal & Veterinary
			Research material, viral infectious diseases
			Bioassays
			Research material
			2015
			Influenza, influenza virus, monoclonal antibody, neuraminidase, CD6, immunoassay, anti-neuraminidase, neuraminidase 1 (N1), neuraminidase 2 (N2), neuraminidase 9 (N9), research tools, diagnostic assays, vaccine developmentNonpathogenic Bacteria, Paenibacillus alvei, Useful As a Natural Biocontrol Agent for Elimination of Food-Borne Pathogenic Bacteria
			E-2014-007
			Drugs
			Bacterial Infectious Disease, Antimicrobial
			Therapeutics, drug design
			*in vitro*
			2014
			antimicrobial, peptides, bacterial, infectious disease, salmonela, paenibacillus alvei, bactericideHemoglobin-Polymer Phantoms for Biophotonic Device Performance Evaluation
			E-2016-002
			Devices
			Medical Devices
			Imaging, Medical device
			Prototype
			2016
			hemoglobin polymer phantoms, biophotonic, device, imaging systemsTissue-mimicking polymer test phantoms for optical-acoustic medical imaging.
			E-2016-003
			Devices
			
			Imaging, Medical Device
			Prototype
			2016
			Photoacoustic, imaging, phantom, optical, acoustic, tunable, magnetic, tomography, diagnostic, sound, pfefer, tissue, mimicAnti-influenza Monoclonal Antibodies to Hemagglutinin (HA) That Are Suitable for Identification and Quantification of Seasonal Influenza Vaccines
			E-2016-004
			Biologics
			Viral Infectious Diseases
			Bioassay, Diagnostics, Vaccine
			In vitro data
			2016
			influenza, monoclonal, antibodies, glycoprotein, strain, epidemic, hemagglutinin, protein, pandemic, virus, vaccine, weir, H1N1, vaccination, diagnostic, assaySolid-phase Purification of Synthetic DNA Sequences
			E-2016-005
			Drugs
			Chemicals, Pesticides, & Metals
			Cellular and gene therapy, therapeutics, drug delivery
			In vitro data
			2016
			solid-phase, purification, synthetic, DNA, sequence, high-throughput, method, design, purity, technique, nucleotide, manufacture, beaucageTherapeutic and Prophylactic Anti-Influenza Virus Neuraminidase 1 (N1) Antibody (Cd6) With a Novel Epitope That Spans Neuraminidase (Na) Dimers
			E-2015-001
			Biologics
			Viral Infectious Disease
			Vaccines, Diagnostics, Bioassays
			*in vitro* and *in vivo*
			2015
			CD6, neutralizing antibody, neuraminidase, hemegglutinin, influenza virus, viralUse of Nonpathogenic Bacteria, *Paenibacillus Alvei*, as a Natural Biocontrol Agent for Elimination of Food-Borne Pathogenic Bacteria
			E-2011-003
			Food
			Food Safety, Chemicals, Pesticides, & Metals
			Therapeutics, drug design
			Pre-development
			2011
			TS-15, food, borne, pathogens, Salmonella, Escherichia, Listeria, Shigella, Enterobacter, Staphylococcus, food supply, biocontrol, agent, pesticide, fruits, vegetable, food-borne, pathogen, antibiotic, resistant, Agriculture, Brown, ZhangNanoparticulate Complex of Nicotine and Cerium Oxide for the Treatment of Parkinson’s Disease
			E-2014-002
			Drugs
			Neuroscience & Pain
			Nanotechnology
			In vitro data
			2014
			tobacco, Parkinson's, nicotine, conjugate, nanoceria, anti-oxidant, oxidant, neuronal, ImamVaccine for Protection Against Shigella sonnei Disease
			E-2001-016
			Biologics
			Bacterial Infectious Diseases
			Vaccines, Diagnostics
			In vivo animal data
			2001
			Shigellosis, food, water, bacterium, Shigella, sonnei, antibiotics, resistant, vaccine, Shigellae, polysaccharide, immunoprotective, vaccine, mice, Shigella, Typhoid, Kopecko, Xu, CisarTyphoid-Plague Bivalent Vaccine
			E-2011-007
			Biologics
			Bacterial Infectious Diseases
			Vaccines, Diagnostics, Therapeutics
			
			2011
			Yersinia, pestis, plague, flea, lungs, pneumonic, bioterrorist, vaccine, oral, construct, fusion, attenuated, typhoid, fever, bacterial, immune, anthrax, delivery, therapeutics, diagnostics, Vector, Kopecko, Osorio, FooteA Novel Anthrax Vaccine Candidate
			E-2003-032
			Biologics
			Bacterial Infectious Diseases
			Vaccines, Diagnostics, Therapeutics
			In vivo animal data
			2003
			vaccine, anthrax, injectable, anthracis, Escherichia, coli, alpha, hemolysin, typhoid, Salmonella, enterica, serovar, Typhi, Immunization, mice, serum, immunoglobulin, toxin, neutralizing, Vaccinated, intranasal, aerosolized, spores, Anthrax, Kopecko, Osorio, Giri, Blake, BhattacharyyaLive Oral Shigella dysenteriae Vaccine
			E-2004-022
			Biologics
			Bacterial Infectious Diseases, Food Safety
			Vaccines, Diagnostics, Therapeutics
			in vivo
			2004
			Salmonella, typhi, construct, Shigella, dysenteriae, polysaccharide, Ty21a, constructs, immune, dysentery, serotypes, dysentery, shigellosis, Kopecko, XuOral Shigellosis Vaccine
			E-2012-016
			Biologics
			Bacterial Infectious Diseases, Food Safety
			Vaccines, Diagnostics, Therapeutics
			
			2012
			Salmonella, typhi, Shigella, sonnei, biosynthetic, constructs, immune, antigenic, bacterial, Bacillary, dysentery, enteric, fever, dysentery, vaccine, resistance, multivalent, Shigellosis, Dharmasena, KopeckoSynthetic Peptides with Antimicrobial Activity
			E-2012-023
			Biologics
			Bacterial Infectious Diseases
			Therapeutics, Diagnostics
			In vitro data
			2012
			synthetic, peptides, antimicrobial, E., coli, aeruginosa, S. aureus, S. epidermidis, B. cereus, K. pneumonia, platelets, plasma, cytotoxic, blood, toxicity, drug, development, resistant, bacterial, antimicrobial, Atreya, Rao, KethaRespiratory Syncytial Virus (RSV) Vaccine Candidates from RSV Glycoprotein (G) and Fusion (F) Protein
			E-2013-016,
			E-2015-010,
			E-2018-001
			Biologics
			Viral Infectious Diseases
			Vaccines
			In vitro data
			2013, 2015, 2018
			cross, neutralizing, vaccine, human, respiratory, syncytial, viru, immunogenic, recombinant, vaccines, immunogenicity, Khurana, GoldingSoftware for Evaluating Drug Induced Hepatotoxicity
			E-2012-008
			Software
			Hepatology, drug interactions
			Drug interactions, software, research tool
			
			2014
			hepatotoxicity, Guo, SAS, Research tool, software, liverUse of Cysteamine to Treat Metastatic Cancer
			E-2013-010
			Drugs
			Oncology, Neuroscience & Pain
			Therapeutics
			In vivo animal data
			2013
			Cysteamine, aminothiol, anti-oxidant, radiation, neurological, cancer, matrix, metalloproteinases, MMP, tumor, metastasis, metastasis, xenograft, umor, mice, therapeutic, Puri, JoshiTherapeutic Hepatitis C Virus Antibodies
			E-2012-002
			Biologics
			Viral Infectious Diseases, Hepatology
			Therapeutics
			In vitro data
			2012
			Therapeutic, antibodies, Hepatitis, Virus, HCV, interfering, neutralizing, infection, monoclonal, liver, transplants, Feinstone, Duan, Major, Zhang, KachkoMultivalent Meningiococcal Conjugates and Methods for Preparing Conjugates
			E-2012-005
			Biologics
			Bacterial Infectious Diseases
			Vaccines
			
			2012
			meningococcal, polysaccharide, vaccines, tetravalent, PS, tetravalent, conjugate, meningococcal, Neisseria, meningitidis, immunogen, vaccine, autoimmune, immunogenic, conjugates, polysaccharide, Neisserial, Lee, PintoNanoparticle Probes and Mid-Infrared Chemical Imaging for DNA Microarray Detection
			E-2010-015
			Biologics, Food
			Environmental Science
			Imaging, Nanotechnology, Diagnostics, Biomarkers
			
			2010
			microarray, visualization, infrared, chemical, imaging, IRCI, nanostructure, DNA, microarray, gene, expression, single, nucleotide, polymorphisms, SNPs, genome, signal-to-noise, SNR, hybridized, microarrayed, fluorescence, pathogenic, fluorescent, microarrays, protein, tissue, biochemical, chemical, toxicogenomics, microarray, Mossoba, Al-Khaldi, SchoenFilovirus Vaccines and Diagnostics Based on Glycoprotein-Fc Fusion Proteins
			E-2010-018
			Biologics
			Viral Infectious Diseases
			Vaccines, Diagnostics
			In vivo animal data
			2010
			Ebola, virus, Filoviridae, bioterrorism, hemorrhagic, fever, primates, Filovirus, subunit, vaccine, extracellular, glycoprotein, immunoglobulin, humoral, cellular, immunity, Vesicular, Stomatitis, Virus, response, Vaccine, virus-like particles, Kaplan, Konduru, Bavari, BradfutePurified Saxitoxin for Food Safety Applications
			E-2009-010
			Food
			Natural Toxins, Food Safety
			Biomarkers, Bioassays
			
			2009
			Saxitoxin, toxins, seafood, food, borne, illness, Monitoring, contamination, Detection, poisons, HallPeptides for HIV-1 Infection Detection Assay for Seroconverted HIV-1 Vaccine Recipients
			E-2004-030
			Biologics
			Viral Infectious Diseases
			Bioassays
			
			2004Highly Adaptable Internal Control Nucleic Acid Molecule for Real-Time Polymerase Chain Reaction
			E-2003-016
			Biologics, Food, Devices
			Diagnostics, Bioassays
			Diagnostics, Bioassays
			
			2003
			PCR, internal, control, system, real, time, PCR, kinetic, Q-PCR, conventional, assay, Vickery, DePaola, BlackstoneDirect Impact Spark Ionization (DISI) Mass Spectrometry (MS) for Identification of Microbes
			E-2011-021
			Devices
			Food Safety, Environmental Science
			Monitoring, Biodefense
			
			2011
			mass, spectrometry, device, direct, impact, spark, ionization, microbial, analytes, identification, pectral, pattern, recognition, microbiological, pathogen, determination, drugs, food, cosmetic, ingredients, monitoring, airborne, Biological, Warfare, Agents, Pathogen, bacterial, Wilkes, Alusta, Dorey, Parker, BuzatuBacterially Expressed Influenza Virus Recombinant HA Proteins for Vaccine and Diagnostic Applications
			E-2010-004
			Biologics
			Viral Infectious Diseases
			Vaccines, Diagnostics
			
			2010
			H1N1, influenza, virus, Avian, pandemic, chicken, egg, HA, H1N1, H5N1, neutralizing, antibody, in vivo, animalÂ , models, vaccine, diagnostic, Golding, KhuranaNovel Methods for the Reversible Incorporation of Functional Groups into RNA and DNA: Synthesis and Uses for 2'-O-aminooxymethyl Nucleoside Derivatives
			E-2010-019
			Drugs, Biologics
			
			Diagnostics, Cellular & Gene Therapy, Drug Delivery, Small Molecule Therapeutics, Drug Design
			
			2010
			DNA, RNA, therapeutic, drugs, silencing, expression, genes, interference, synthetic, synthesis, oligonucleotides, diagnostic, therapeutic, Beaucage, CieslakMeningococcal and Pneumococcal Conjugate Vaccine and Method of Using Same
			E-2010-002
			Biologics
			Bacterial Infectious Diseases
			Vaccines
			
			2010
			Pneumococcal, Streptococcus, pneumoniae, pneumonia, meningitis, febrile, bacteremia, otitis, media, sinusitis, bronchitis, Vaccination, microbial resistance, bacterial, meningococcus, Neisseria, meningitidis, respiratory, meningeal, septic, pneumonia, meningitis, vaccine, pathogen, conjugate, vaccines, recombinant, LeeSystem for Magnetic Resonance Spectroscopy of Brain Tissue for Pattern-based Diagnostics
			E-2009-011
			Devices
			Neuroscience & Pain
			Medical Devices, Imaging
			
			2009
			Magnetic, resonance, spectroscopy, MRS, Brain, Tissue, Pattern, Based, Diagnostic, Preprocessing, Module, Spectrum, Normalize, Scan, Raw, MRI, Brain, Imaging, Neurology, Wilkes, Buzatu, Alusta, Pearce, Kretzer, Im, BegerInsertion of Foreign Genes in Rubella Virus and their Stable Expression in a Live, Attenuated Viral Vaccine
			E-2008-011
			Biologics
			Viral Infectious Diseases
			Vaccines
			
			2008
			Rubella, virus, RUB, Rubivirus, Togaviridae, genes, vector, live, vaccine, HIV, vector, expression, Berkower, SpadacciniA Hand Held Portable Device Based on LEDS for Use in The Detection of Counterfeit Pharmaceutical Drugs and Packaging
			E-2008-017
			Devices, Drugs
			
			Post-Market Surveillance, Monitoring
			Prototype
			2008
			hand, held, portable, device, detection, counterfeited, pharmaceutical, prototype, light, emitting, diode, LED, Testing, authenticity, RanieriNovel Oligonucleotides for Treatment of Human Cancer
			E-2008-007
			Drugs, Biologics
			Oncology
			Therapeutics, Cellular & Gene Therapy
			
			2008
			Human, endogenous, retroviruses, HERV, antisense, sense, oligonucleotides, RNA, ERV-9, LTR, cancer, breast, liver, prostate, myeloid, fibrosarcoma, therapeutic, tumor, siRNA, gene, expression, Therapeutic, Xu, Rosenberg, Elkahloun, CandottiControlled Formation of CpG Oligonucleotide Multimers
			E-2004-024
			Drugs, Biologics
			Adjuvants; Vaccines; Oligonucleotide Therapeutics
			Drug design; Cellular and gene therapies; Molecule delivery
			*in vitro* data; *in vivo* data; preclinical primate studies
			2004
			CpG, oligonucleotides, oligonucleotide, prodrug, Therapeutic, immune, immunostimulatory, Verthelyi, Beaucage, GrajkowskiUse of Sterically Stabilized Cationic Liposomes to Efficiently Deliver CpG Oligonucleotides in vivo
			E-2001-020
			Drugs
			Immunotherapy
			Drug Delivery, Drug Design, Cellular & Gene Therapy
			*In vitro* data, *In vivo* animal data
			2001
			Immunostimulatory, CpG, oligonucleotide, ODN, immune, adjuvant, anti-allergens, Sterically, Stabilized, Cationic, Liposomes, SSCL, in vivo, in vitro, mice, L. monocytogenes, listeria, Klinman, GurselIdentification of DNA Sequence Motifs that Suppress the Immune Response to CpG DNA
			E-2001-021
			Drugs
			Immunotherapy
			Cellular & Gene Therapy
			
			2001
			CpG, oligonucleotide, immunostimulatory, oligodeoxynucleotides, ODN, septic, shock, adult, respiratory, distress, syndrome, ARDS, autoimmune, disease, suppressive, vaccine, therapeutic, Klinman, GurselMonoclonal Antibodies to Fusion-Active Conformations of HIV-gp41
			E-2007-011
			Biologics
			Viral Infectious Diseases
			Bioassays, Therapeutics
			
			2007
			monoclonal, HIV, gp41, tool, screening, antiretroviral, Research, Weiss, VassellDiagnostic Targets and Potential Vaccine Against H5N1 Avian Influenza
			E-2007-026
			Biologics
			Viral Infectious Diseases
			Therapeutics, Vaccines
			in vivo studies
			2007
			peptide, polypeptide, influenza, virusÂ , immunogenic, neutralizing, antibodies, avian, H1N1, H3N2, H5N1, H7N7, immunogenic, adjuvant, vaccine, Diagnostic, Golding, KhuranaOligodeoxynucleotide and Its Use To Induce an Immune Response
			E-1999-009
			Biologics
			Oncology, Immunotherapy
			Cellular & Gene Therapy, Vaccines
			
			1999
			oligodeoxynucleotides, ODN, CpG, immunostimulatory, immune, production, T cell, therapeutic, cancer, vaccine, adjuvant, autoimmune, disorders, immune, deficiencies, anti-infective, antisense, therapy, Klinman, Verthelyi, Ishii, GurselNeutralization of Hepatitis C Virus (HCV)
			E-2007-028
			
			Viral Infectious Diseases
			Therapeutics
			
			2007Improved Immunotherapeutic Compositions for Treatment, Diagnosis and Prevention of HIV
			E-2008-027
			Biologics
			Viral Infectious Diseases
			Therapeutics, Vaccines, Diagnostics
			
			2008
			HIV, vaccine, neutralizing, antibodies, glycoprotein, immune, immunization, gp120, immunogen, polypeptide, virus-like, particles, TLR, therapeutics, diagnostics, BerkowerMouse Monoclonal Antibody Targeting Tetanus Toxin Heavy Chain Fragment C
			E-2009-003
			Biologics
			Bacterial Infectious Diseases, Natural Toxins
			Therapeutics
			
			2009
			murine, monoclonal, antibody, tetanus, toxin, neurotoxin, neuron, botulinum, antitoxins, Shapiro, FitzsimmonsMembrane Proximal Region of HIV gp41 Anchored to the Lipid Layer of a Virus-Like Particle Vaccine
			E-2008-026
			Biologics
			Viral Infectious Diseases
			Therapeutics, Vaccines, Diagnostics
			
			2008
			HIV, envelope, glycoprotein, gp120, gp41, immunogenic, antibodies, immune, membrane, proximal, region, MPR, hepatitis, surface, antigen, HBsAg, epitope, HumanÂ , ImmunodeficiencyÂ , Virus, vaccine, therapeutic, diagnostic, BerkowerCompounds Used to Improve Human Immune Responses in Diseases such as Allergies, Infections, and Cancer
			E-2000-011
			Drugs
			Immunotherapy, Oncology, Viral Infectious Diseases, Bacterial Infectious Diseases,
			Fungal & Parasitic Infectious Diseases
			Cellular & Gene Therapy, Vaccines, Drug Design
			
			2000
			immune, oligonucleotide, CpG, therapeutic, immunomodulatory, humoral, cell-mediated, allergies, infectious, diseases, cancer, autoimmune, vaccine, adjuvant, DNA, anti-sense, Klinman, Verthelyi, IshiiA Method with Increased Yield for Production of Polysaccharide-Protein Conjugate Vaccines Using Hydrazide Chemistry
			E-2003-025;
			E-2003-026
			Biologics
			Viral Infectious Diseases, Bacterial Infectious Diseases
			Vaccines, Drug Design
			
			2003
			synthesis, manufacturing, polysaccharide, conjugate, vaccine, conjugation, PS, hydrazide, manufacturing, conjugate, Lee, FraschMethod of Treating and Preventing Infections in Immunocompromised Subjects with Immunostimulatory CpG Oligonucleotides
			E-2002-018
			Drugs, Biologics
			Pulmonary, Immunotherapy
			Cellular & Gene Therapy, Vaccines
			
			2002
			Lung, chronic, inflammatory, lung, emphysema, chronic, bronchitis, acute, respiratory, distress, syndrome, ARDS, inflammation, suppressive, oligonucleotide, pneumonia, Vaccine, adjuvant, production, immunotherapeutics, Klinman, YamadaMethods for Preparing Complex Multivalent Immunogenic Conjugates
			E-2005-015
			Biologics
			Viral Infectious Diseases, Bacterial Infectious Diseases
			Vaccines, Drug Design
			
			2005
			multivalent, immunogenic, conjugates, conjugate, vaccine, polysaccharide, hydrazide, conjugation, LeeMonoclonal Antibodies Against Bordetella pertussis Filamentous Hemagglutinin (FHA) Protein
			E-2008-001
			Biologics
			Bacterial Infectious Diseases
			Vaccines, Therapeutics, Diagnostics
			
			2008Identification of a Cell-Surface Co-Receptor that Mediates the Uptake and Immunostimulatory Activity of "D" Type CpG Oligonucleotides
			E-2005-004
			Drugs, Biologics
			Immunotherapy
			Cellular & Gene Therapy, Vaccines, Drug Delivery
			
			2005
			CpG, immune, proinflammatory, oligonucleotides, scavenger receptor, immune, Vaccine, adjuvant, production, immunotherapeutics, Klinman, GurselHollow Waveguide Laser Delivery System for Digital Particle Image Velocity
			E-2006-001
			Devices
			
			Imaging
			
			2006
			laser, delivery, system, digital, particle, image, velocimetry, DPIV, illumination, Optics, Ilev, Robinson, WaynantConfocal Fiber-Optic Laser Method for Intraocular Lens Power Measurement
			E-2005-007
			Devices
			Ophthalmology
			Medical Devices
			
			2005
			fiber, optic, laser, confocal, Intraocular, lens, IOL, dioptic, power, measurement, single-mode, optical, IlevUltrahigh-Resolution Fiber-Optic Confocal Microscope And Method
			E-2005-006
			Devices
			
			Medical Devices
			
			2005
			single, mode, fiber, optic, confocal, microscope, ultrahigh, resolution, illumination, Ilev, Waynant, Gannot, GandjbakhcheMonoclonal Antibody 90.12 Specific to a Novel B Cell Surface Antigen Upregulated on Both Activated and Apoptotic Lymphocytes
			E-2004-019
			Biologics
			Oncology
			Therapeutics
			
			2004
			Monoclonal, antibody, calcium, binding, proteins, ShapiroThermolytic Hydroxyl-Protecting Groups for Improved Oligonucleotide Synthesis
			E-2003-008
			Biologics, Drugs
			Gene therapy
			Vaccines, Cellular & Gene Therapy, Drug Design, Diagnostics, Bioassays, Monitoring
			
			2003
			Synthetic, oligonucleotide, gene, therapy, diagnostic, DNA, sequencing, microarray, glass, synthesis, Beaucage, ChmielewskiUse of CpG Oligodeoxynucleotides to Encourage Angiogenesis
			E-2001-030
			Biologics, Drugs
			Oncology
			Cellular & Gene Therapy
			
			2001
			angiogenesis, CpG, oligonucleotide, tumor, atherogenesis, arthritis, corneal, neovascularization, diabetic, retinopathy, wound, healing, malignancies, oligodeoxynucleotide, ODN, vaccine, adjuvant, anti-allergens, immune, central, nervous, system, cornea, VEGF, Vascular, Endothelial, Growth, Factor, KlinmanMicrobial Identification Databases
			E-2000-025
			Food, Biologics, Drugs, Animal & Veterinary
			Viral Infectious Diseases, Bacterial Infectious Diseases, Fungal & Parasitic Infectious Diseases, Food Safety, Environmental Science
			Monitoring, Post-Market Surveillance, Biodefense
			
			2000
			database, pyrolysis, mass, spectra, chemotaxonomy, microbial, MALDI, infrared, chromatogram, NMR, ion, mobility, microorganism, pathogen, WilkesNovel Method for Rapidly Generating Mature Dendritic Cells from Peripheral Blood Monocytes and Myeloid Precursors
			E-2001-019
			Biologics, Drugs
			Immunotherapy
			Cellular & Gene Therapy, Therapeutics
			
			2001
			CpG, oligodeoxynucleotide, ODN, dendritic, DC, cytokines, chemokines, monocytes, dendritic, immune, cancer, infectious, disease, Klinman, Gursel, Verthelyi

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