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                Bioinformatics Tools

Bioinformatics Tools

                        Bioinformatics Publications
          Database of Pharmacogenomic Information in Ethnic Minority Populations (dbPGxEMP)
          de novo Assembly Quality Evaluation Tool (dnAQET)
          FDALabel:  Full-Text Search of Drug Product Labeling


                        ArrayTrackTM HCA-PCA Standalone Package – powerful data-exploring tools
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          Database of Pharmacogenomic Information in Ethnic Minority Populations (dbPGxEMP)Bioinformatics Tools Database of Pharmacogenomic Information in Ethnic Minority Populations (dbPGxEMP)
  
  					Integrative database linking drugs, pharmacogenomic biomarkers, and genetic variations in minority populations
	
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Differences in genes can make someone more or less likely to benefit from a drug, suffer side effects, or require a dose that is different from other people. Such pharmacogenomic (PGx) information can be used to improve the medical decision-making process and minimize severe adverse drug reactions. This database was developed to connect drugs and PGx biomarkers from drug labeling with allele frequencies of related genetic variations in different ethnic minority populations.

The Database of Pharmacogenomic Information in Ethnic Minority Populations (dbPGxEMP) includes information on nonsynonymous single nucleotide polymorphisms (SNPs) that cause frameshift, missense, or nonsense only. In the current database version (version 1.0), 42 drugs, 16 PGx biomarkers, and 67 SNPs with allele frequency information are included. Oncology drugs and their related biomarkers are excluded from this database. dbPGxEMP will be updated quarterly.

Download the dbPGxEMP zip file (127.85 KB)
*(version 1 updated on 12/01/2020)*

**Note:***Running dbPGxEMP requires Microsoft Access installed.*
	**Please contact**NCTRBioinformaticsSupport@fda.hhs.gov if you need assistance with accessing any documents contained inside the zip file.**



Reference

**Linking Pharmacogenomic Information on Drug Safety and Efficacy with Ethnic Minority Populations.**
Li D., Xie A.H., Liu Z., Li D., Ning B., Thakkar S., Tong W., and Xu J.  *Pharmaceutics.*12, 2020.



Contact Information

Functions
			Contacts*Questions, Suggestions, or Get Assistance:*
			Joshua Xu, Ph.D. (Joshua.xu@fda.hhs.gov)

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                                                                                  Content current as of:
      08/16/2022
              
              
Topic(s)
			  Bioinformatics
				    				       				    				       Biostatistics
				       				    				       DiversityBioinformatics Tools

          
                        Publications
          Database of Pharmacogenomic Information in Ethnic Minority Populations (dbPGxEMP)
          de novo Assembly Quality Evaluation Tool (dnAQET)
          FDALabel:  Full-Text Search of Drug Product Labeling


                        ArrayTrackTM HCA-PCA Standalone Package – powerful data-exploring tools
          Decision Forest
          Endocrine Disruptor Knowledge Base (EDKB)
          Estrogenic Activity Database (EADB)
          Liver Toxicity Knowledge Base (LTKB)
          MicroArray/Sequencing Quality Control (MAQC/SEQC)
          Mold2
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