Exhibit 4.3

                          IR BIOSCIENCES HOLDINGS, INC.
                        2003 STOCK OPTION, DEFERRED STOCK
                            AND RESTRICTED STOCK PLAN

                             STOCK OPTION AGREEMENT
                                   (EXECUTIVE)


NAME: ___________________

      This AGREEMENT is made effective as of the ___day of ___________, _______
(the "Option Grant Date"), by and between IR BioSciences Holdings, Inc., a
Delaware corporation (the "Company") and ________________ (the "Optionee").

                                    RECITALS

      WHEREAS, the Company has established the 2003 Stock Option, Deferred Stock
and Restricted Stock Plan (the "Plan") effective as of June 26, 2003, and

      WHEREAS, pursuant to the provisions of said Plan, the Administrator has
granted to the Participant by action duly taken on ________ __, 200_, (the
"Award Date") a stock option award (the "Stock Option Award") based upon the
terms and conditions set forth herein.

      NOW, THEREFORE, in consideration of services rendered and to be rendered
by the Participant and the mutual promises and covenants made herein, the mutual
benefits to be derived therefrom and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties agree as
follows:

                                    AGREEMENT

      1. The Option(s). The Optionee may, at his/her option, purchase all or any
part of an aggregate of __________ shares of Common Stock (the "Optioned
Shares"), at the price of $_________ per share (the "Option Price"), on the
terms and conditions set forth herein.

      2. Option Type; Exercise Dates and Exercise. Options intended to qualify
as Incentive Stock Options are designated by an "ISO" under the category "Type."
Options intended as separate Non-Qualified Stock Options are designated by a
"NQSO" under the category "Type." The Option(s) shall be exercisable as to the
specified number of Optioned Shares on and after the "First" dates and on or
before the "Last" dates set forth below:

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Type             Number of Shares       First and Last Date
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      Optionee acknowledges that he/she understands he/she has no right
whatsoever to exercise the Option(s) granted hereunder with respect to any
Optioned Shares covered by any installment until such installment accrues (and
is thus vested) as provided above. Optionee further understands that the
Option(s) granted hereunder shall expire and become unexercisable as provided in
Section 4(c) below.

      In the event, within twelve (12) months after a Change in Control, the
Optionee's employment terminates other than (i) for Cause, (ii) voluntary
termination by the Optionee, or (iii) death or disability of the Optionee, fifty
percent (50%) of the unvested Optioned Shares shall vest upon the date of such
termination. For the purposes of the foregoing, a "Change in Control" shall have
the meaning set forth in Section 9(b) of the Plan. For purposes of this
Agreement, "Cause" shall mean (i) a material act of dishonesty in connection
with the Optionee's responsibilities as an employee of the Company; (ii) the
Optionee's conviction of, or plea of nolo contendere to, a felony or a crime
involving moral turpitude, (iii) the Optionee's gross misconduct which has a
material adverse effect on the Company, or (iv) the Optionee's consistent and
willful failure to perform his or her employment duties where such failure is
not cured within 30 days after written notice to participant by the Company.

      3. Method of Exercise. This Option shall be deemed exercised as to the
shares to be purchased when written notice of such exercise has been given to
the Company at its principal business office by the Optionee with respect to the
Common Stock to be purchased. Such notice shall be accompanied by full payment
in cash or cash equivalents as determined by the Administrator. As determined by
the Administrator, in its sole discretion, payment in whole or part may also be
made (i) in the form of unrestricted Stock already owned by the Optionee, or, in
the case of the exercise of a Non-Qualified Stock Option, Restricted Stock
subject to an Award hereunder (based, in each case, on the Fair Market Value of
the Stock), (ii) by cancellation of any indebtedness owed by the Company to the
Optionee, (iii) by a full recourse promissory note executed by the Optionee,
(iv) by requesting that the Company withhold whole shares of Common Stock then
issuable upon exercise of the Stock Option (based on the Fair Market Value of
the Stock), (v) by arrangement with a broker which is acceptable to the
Administrator where payment of the option price is made pursuant to an
irrevocable direction to the broker to deliver all or part of the proceeds from
the sale of the shares underlying the option to the Company, or (vi) by any
combination of the foregoing; provided, however, that in the case of an
Incentive Stock Option, the right to make payment in the form of already owned
shares may be authorized only at the time of grant. Any payment in the form of
Stock already owned by the Optionee may be effected by use of an attestation
form approved by the Administrator. If payment of the option exercise price of a
NQSO is made in whole or in part in the form of Restricted Stock or Deferred


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Stock, the shares received upon the exercise of such Option (to the extent of
the number of shares of Restricted Stock or Deferred Stock surrendered upon
exercise of such Option) shall be restricted in accordance with the original
terms of the Restricted Stock or Deferred Stock award in question, except that
the Administrator may direct that such restrictions shall apply only to that
number of shares surrendered upon the exercise of such Option.

      4. Governing Plan. This Agreement hereby incorporates by reference the
Plan and all of the terms and conditions of the Plan as heretofore amended and
as the same may be amended from time to time hereafter in accordance with the
terms thereof, but no such subsequent amendment shall adversely affect the
Optionee's rights under this Agreement and the Plan except as may be required by
applicable law. The Optionee expressly acknowledges and agrees that the
provisions of this Agreement are subject to the Plan; the terms of this
Agreement shall in no manner limit or modify the controlling provisions of the
Plan, and in case of any conflict between the provisions of the Plan and this
Agreement, the provisions of the Plan shall be controlling and binding upon the
parties hereto. The Optionee also hereby expressly acknowledges, represents and
agrees as follows:

            (a) Acknowledges receipt of a copy of the Plan, a copy of which is
attached hereto and by reference incorporated herein, and represents that he/she
is familiar with the terms and provisions of said Plan, and hereby accepts this
Agreement subject to all the terms and provisions of said Plan.

            (b) Agrees to accept as binding, conclusive and final all decisions
or interpretations of the Administrator upon any questions arising under the
Plan.

            (c) Acknowledges that he/she is familiar with Sections of the Plan
regarding the exercise of the Option(s) and represents that he/she understands
that said Option(s) must be exercised on or before the "Last" exercise date
noted above in Section 2 or such other date as set forth in the Plan, whichever
is earlier.

            (d) Acknowledges, understands and agrees that the existence of the
Plan and the execution of this Agreement are not sufficient by themselves to
cause any exercise of any Option(s) granted as an Incentive Stock Option to
qualify for favorable tax treatment through the application of Section 422 of
the Internal Revenue Code; that Optionee must, in order to so qualify,
individually meet by his own action all applicable requirements of Section 422,
including without limitation the following holding period and employment
requirements:

                  (1) holding period requirement: no disposition of an Optioned
Share may be made by Optionee within two (2) years from the date of the granting
of the Option(s) nor within one (1) year after the transfer of such Optioned
Share to him/her, and

                  (2) employment requirement: at all times during the period
beginning on the date of the granting of the Option(s) and ending on the day
three (3) months before the date of exercise, the Optionee must have been an
employee of the Company, its Parent, or a Subsidiary of the Company, or a
corporation or a parent or subsidiary of such corporation issuing or assuming


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<PAGE>

the Option(s) in a transaction to which Section 425(a) of the Internal Revenue
Code applies, except where the termination of employment is by means of the
employee's disability, in which case said three (3) month period may be extended
to one (1) year, as provided under Internal Revenue Code Section 422.

      5. Representations and Warranties. Optionee hereby represents to the
Company that each of the Options evidenced hereby and the shares purchasable
upon exercise thereof are being acquired only for investment and without any
present intention to sell or distribute such securities.

      6. Options Not Transferable. No Stock Option shall be transferable by the
Optionee other than by will or by the laws of descent and distribution.
Incentive Stock Options shall be exercisable, during the Optionee's lifetime,
only by the Optionee or, with respect to Non-Qualified Stock Options, in
accordance with the terms of a qualified domestic relations order.

      7. No Enlargement of Employee Rights. Nothing in this Agreement shall be
construed to confer upon the Optionee (if an employee) any right to continued
employment with the Company or to restrict in any way the right of the Company
to terminate his/her employment. Optionee acknowledges that in the absence of an
express written employment agreement to the contrary, the Company may terminate
Optionee's employment with the Company at any time, with or without cause.

      8. Withholding of Taxes. Optionee authorizes the Company to withhold, in
accordance with any applicable law, from any compensation payable to him any
taxes required to be withheld by federal, state or local law as a result of the
grant of the Option(s) or the issuance of stock pursuant to the exercise of such
Option(s).

      9. Laws Applicable to Construction. This Agreement shall be construed and
enforced in accordance with the laws of the State of Delaware.

      10. Agreement Binding on Successors. The terms of this Agreement shall be
binding upon the executors, administrators, heirs, successors, transferees and
assignees of the Optionee.

      11. Costs of Litigation. In any action at law or in equity to enforce any
of the provisions or rights under this Agreement or the Plan, the unsuccessful
party to such litigation, as determined by the court in a final judgment or
decree, shall pay the successful party or parties all costs, expenses and
reasonable attorneys' fees incurred by the successful party or parties
(including without limitation costs, expenses end fees on any appeals), and if
the successful party recovers judgment in any such action or proceeding such
costs, expenses and attorneys' fees shall be included as part of the judgment.

      12. Necessary Acts. The Optionee agrees to perform all acts and execute
and deliver any documents that may be reasonably necessary to carry out the
provisions of this Agreement, including but not limited to all acts and
documents related to compliance with federal and/or state securities laws.


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<PAGE>

      13. Counterparts. For convenience this Agreement may be executed in any
number of identical counterparts, each of which shall be deemed a complete
original in itself and may be introduced in evidence or used for any other
purpose without the production of any other counterparts.

      14. Invalid Provisions. In the event that any provision of this Agreement
is found to be invalid or otherwise unenforceable under any applicable law, such
invalidity or unenforceability shall not be construed as rendering any other
provisions contained herein invalid or unenforceable, and all such other
provisions shall be given full force and effect to the same extent as though the
invalid and unenforceable provision was not contained herein.

      15. Limitation on Value of Optioned Shares. Optionee acknowledges that the
Plan provides that the aggregate fair market value (determined as of the date
hereof) of the shares of Common Stock to which Options granted as Incentive
Stock Options are exercisable for the first time by Optionee during any calendar
year under all incentive stock option plans of the Company and any future
Subsidiary shall not exceed $100,000. It is understood and agreed that should it
be determined that an Option if granted as an Incentive Stock Option hereunder
would exceed such maximum, such Option shall be considered granted as a
Non-Qualified Stock Option to the extent, but only to the extent of such excess.
This limitation shall not apply to any option granted as a Non-Qualified Stock
Option.


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<PAGE>

         IN WITNESS WHEREOF, the Company and the Optionee have executed this
Agreement effective as of the date first written hereinabove.

IR BIOSCIENCES HOLDINGS, INC.                        OPTIONEE

By:
    ---------------------------              -------------------------------
    Name:
         ----------------------
    Title:
           --------------------

                                             -------------------------------
                                             (Print Name)


Address of Optionee:

-------------------------------

-------------------------------

-------------------------------

                                             -------------------------------
                                             (Social Security)




      By his or her signature below, the spouse of the Optionee, if such
Optionee be legally married as of the date of his execution of this Agreement,
acknowledges that he or she has read this Agreement and the Plan and is familiar
with the terms and provisions thereof, and agrees to be bound by all the terms
and conditions of said Agreement and said Plan document.


                                             -------------------------------
                                             Spouse

                                             Dated: ________________________


      By his or her signature below the Optionee represents that he or she is
not legally married as of the date of execution of this Agreement.


                                             -------------------------------
                                             Optionee

                                             Dated: ________________________



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