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  Exhibit 10.1    
    


 FORM OF PUBLIC COMPANY

STOCKHOLDER AGREEMENT  


        THIS STOCKHOLDER AGREEMENT (this "Agreement"), dated as of January 27, 2009, is
by and among NitroMed, Inc., a Delaware corporation ("Public Company") (only with respect to Section 2(b) and Section 10(q)),
Deerfield Private Design Fund, L.P., a Delaware limited partnership, Deerfield Private Design International, L.P., a British Virgin Islands limited partnership, Deerfield Special
Situations Fund, L.P., a Delaware limited partnership, Deerfield Special Situations Fund International Limited, a British Virgin Islands corporation, NTMD Parent Acquisition Corp.,
(collectively "Merger Partner"), and the undersigned stockholder ("Stockholder") of Public Company. 



        WHEREAS,
concurrently with the execution and delivery of this Agreement, Public Company, NTMD Acquisition, Corp., a Delaware corporation and a wholly owned subsidiary of Merger Partner
(the "Transitory Subsidiary"), and Merger Partner have entered into an Agreement and Plan of Merger, dated as of the date hereof (as it may be amended
or supplemented from time to time pursuant to the terms thereof, the "Merger Agreement"), which provides for the merger (the
"Merger") of the Transitory Subsidiary into Public Company in accordance with the terms of the Merger Agreement; 



        WHEREAS,
Stockholder is the beneficial owner (as defined in Rule 13d-3 under the Exchange Act) of such number of shares of each class of capital stock of Public
Company as is indicated on the signature page of this Agreement; and 


        WHEREAS,
in consideration of the execution and delivery of the Merger Agreement by Merger Partner, Stockholder desires to agree to vote the Shares (as defined herein) over which
Stockholder has voting power so as to facilitate the consummation of the Merger; 


        NOW,
THEREFORE, in consideration of the foregoing, intending to be legally bound, the parties hereto hereby agree as follows: 


        1.    Certain Definitions.    



        (a)   Capitalized
terms used but not otherwise defined herein shall have the meanings ascribed thereto in the Merger Agreement. For purposes of this Agreement, the following
terms shall have the following meanings: 



        "Constructive Sale" means with respect to any security, a short sale with respect to such security, entering into or acquiring an
offsetting derivative contract with respect to such security, entering into or acquiring a futures or forward contract to deliver such security or entering into any other hedging or other derivative
transaction that has the effect of either directly or indirectly materially changing the economic benefits or risks of ownership. 


        "Shares" means (i) all shares of capital stock of Public Company owned, beneficially or of record, by Stockholder as of the date
hereof, and (ii) all additional shares of capital stock of Public Company acquired by Stockholder, beneficially or of record, during the period commencing with the execution and delivery of
this Agreement and expiring on the Expiration Date (as such term is defined in Section 9 below). 



        "Transfer" means, with respect to any security, the direct or indirect assignment, sale, transfer, tender, exchange, pledge,
hypothecation, or the grant, creation or suffrage of a lien, security interest or encumbrance in or upon, or the gift, placement in trust, or the Constructive Sale or other disposition of such
security (including transfers by testamentary or intestate succession or otherwise by operation of law) or any right, title or interest therein (including, but not limited to, any right or power to
vote to which the holder thereof may be entitled, whether such right or power is granted by proxy or otherwise), or the record or beneficial ownership thereof, the offer to make such a sale, transfer,
Constructive Sale or other disposition, and each agreement, arrangement or understanding, whether or not in writing, to effect any of the foregoing. 









 





        2.    Transfer and Voting Restrictions With Respect to the Shares.    



        (a)   At
all times during the period commencing with the execution and delivery of this Agreement and expiring on the Expiration Date, Stockholder shall not, except as the
result of the death of Stockholder or as otherwise permitted by this Agreement, Transfer any of the Shares, or discuss, negotiate, make an offer or enter into an agreement, commitment or other
arrangement with respect thereto, unless the person to which such Shares are being Transferred shall have executed and delivered a counterpart of this Agreement and agreed pursuant thereto, for the
benefit of Merger Partner, to hold such Shares subject to all terms and conditions of this Agreement. 


        (b)   Stockholder
understands and agrees that if Stockholder attempts to Transfer, vote or provide any other person with the authority to vote any of the Shares other than in
compliance with this Agreement, Public Company shall not, and Stockholder hereby unconditionally and irrevocably instructs Public Company to not, (i) permit any such Transfer on its books and
records, (ii) issue a new certificate representing any of the Shares or (iii) record such vote, in each case, unless and until Stockholder shall have complied with the terms of this
Agreement. 


        (c)   Except
as otherwise permitted by this Agreement or by order of a court of competent jurisdiction, Stockholder will not commit any act that could restrict or affect
Stockholder's legal power, authority and right to vote all of the Shares then owned of record or beneficially by Stockholder or otherwise prevent or disable Stockholder from performing any of his, her
or its obligations under this Agreement. Without limiting the generality of the foregoing, except for this Agreement and as otherwise permitted by this Agreement, Stockholder will not enter into any
voting agreement with any person or entity with respect to any of the Shares, grant any person or entity any proxy (revocable or irrevocable) or power of attorney with respect to any of the Shares,
deposit any of the Shares in a voting trust or otherwise enter into any agreement or arrangement with any person or entity limiting or affecting Stockholder's legal power, authority or right to vote
the Shares in favor of the approval of the Proposed Transaction. 




        3.    Agreement to Vote Shares.    



        (a)   Prior
to the Expiration Date, at every meeting of the stockholders of Public Company called, and at every adjournment or postponement thereof, Stockholder (in
Stockholder's capacity as such) shall appear at the meeting or otherwise cause the Shares to be present thereat for purposes of establishing a quorum and, to the extent not voted by the persons
appointed as proxies pursuant to this Agreement, vote (i) in favor of adoption of the Merger Agreement and approval of the transactions contemplated thereby (collectively, the
"Proposed Transaction"), (ii) against the approval or adoption of any proposal made in opposition to, or in competition with, the Proposed
Transaction, and (iii) against any of the
following (to the extent unrelated to the Proposed Transaction): (A) any merger, consolidation or business combination involving Public Company or any of its subsidiaries other than the
Proposed Transaction; (B) any sale, lease or transfer of all or substantially all of the assets of Public Company or any of its subsidiaries; (C) any reorganization, recapitalization,
dissolution, liquidation or winding up of Public Company or any of its subsidiaries that is prohibited by the Merger Agreement; or (D) any other action that is a breach of any covenant,
representation or warranty or any other obligation or agreement of Public Company under the Merger Agreement or of Stockholder under this Agreement (each of (ii) and (iii), a
"Competing Transaction"). 


        (b)   If
Stockholder is the beneficial owner, but not the record holder, of the Shares, Stockholder agrees to take all actions necessary to cause the record holder and any
nominees to vote all of the Shares in accordance with Section 3(a). 



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        4.    Grant of Irrevocable Proxy.    



        (a)   Except
as set forth in Section 4(f) hereof, Stockholder hereby irrevocably (to the fullest extent permitted by law) grants to, and appoints, Merger Partner and
each of its executive officers and any of them, in their capacities as officers of Merger Partner (the "Grantees"), as Stockholder's proxy and
attorney-in-fact (with full power of substitution and re-substitution), for and in the name, place and stead of Stockholder, to vote the Shares, to instruct
nominees or record holders to vote the Shares, or grant a consent or approval in respect of such Shares in accordance with Section 3 hereof and, in the discretion of the Grantees with respect
to any proposed adjournments or postponements of any meeting of stockholders at which any of the matters described in Section 3 hereof is to be considered. 



        (b)   Stockholder
represents that any proxies heretofore given in respect of the Shares that may still be in effect are not irrevocable, and such proxies are hereby revoked. 


        (c)   Stockholder
hereby affirms that the irrevocable proxy set forth in this Section 4 is given in connection with the execution of the Merger Agreement, and that such
irrevocable proxy is given to secure the performance of the duties of Stockholder under this Agreement. Stockholder hereby further affirms that the irrevocable proxy is coupled with an interest and
may under no circumstances be revoked. Stockholder hereby ratifies and confirms all that such irrevocable proxy may lawfully do or cause to be done by virtue hereof. Such irrevocable proxy is executed
and intended to be irrevocable in accordance with the provisions of Section 212 of the Delaware General Corporation Law. 


        (d)   The
Grantees may not exercise this irrevocable proxy on any other matter except as provided above. Stockholder may vote the Shares on all other matters. 


        (e)   Merger
Partner may terminate this proxy with respect to Stockholder at any time at its sole election by written notice provided to Stockholder. 



        (f)    The
proxy set forth in this Section 4 shall terminate upon the termination of this Agreement in accordance with Section 9 hereof. 




        5.    No Solicitation.    Stockholder, in his, her or its capacity as a Stockholder, shall not directly or indirectly,
(a) solicit, initiate, encourage, induce or knowingly facilitate the communication, making, submission or announcement of any Acquisition Proposal or Acquisition Inquiry or take any action that
could reasonably be expected to lead to an Acquisition Proposal or Acquisition Inquiry, (b) engage in discussions or negotiations with any Person with respect to any Acquisition Proposal or
Acquisition Inquiry, (c) approve, endorse or recommend any Acquisition Proposal, or (d) enter into any letter of intent or similar document or any Contract contemplating or otherwise
relating to any Acquisition Transaction. 


        6.    Action in Stockholder Capacity Only.    Stockholder makes no agreement or understanding herein as a director or
officer of Public Company. Stockholder signs solely in Stockholder's capacity as a record holder and beneficial owner, as applicable, of Shares, and nothing herein shall limit or affect any actions
taken in Stockholder's capacity as an officer or director of Public Company. Nothing herein shall prevent or preclude an officer, director or manager of the Stockholder who is serving as a director of
Public Company from taking or not taking any action in his capacity as a director of Public Company. 


        7.    Representations and Warranties of Stockholder.    



        (a)   Stockholder
hereby represents and warrants to Merger Partner as follows: (i) Stockholder is the beneficial or record owner of the shares of capital stock of
Public Company indicated on the signature page of this Agreement free and clear of any and all pledges, liens, security interests, mortgage, claims, charges, restrictions, options, title defects or
encumbrances except as provided in 



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the
Voting Agreement; (ii) Stockholder does not beneficially own any securities of Public Company other than the shares of capital stock and rights to purchase shares of capital stock of Public
Company set forth on the signature page of this Agreement; (iii) Stockholder has full power and authority to make, enter into and carry out the terms of this Agreement and to grant the
irrevocable proxy as set
forth in Section 4; and (iv) this Agreement has been duly and validly executed and delivered by Stockholder and constitutes a valid and binding agreement of Stockholder enforceable
against Stockholder in accordance with its terms. Stockholder agrees to notify Merger Partner promptly of any additional shares of capital stock of Public Company of which Stockholder becomes the
beneficial owner after the date of this Agreement. 


        (b)   As
of the date hereof and for so long as this Agreement remains in effect, except for this Agreement or as otherwise permitted by this Agreement, Stockholder has full
legal power, authority and right to vote all of the Shares then owned of record or beneficially by Stockholder, in favor of the approval and authorization of the Proposed Transaction without the
consent or approval of, or any other action on the part of, any other person or entity (including, without limitation, any governmental entity). Without limiting the generality of the foregoing,
Stockholder has not entered into any voting agreement (other than this Agreement and the Voting Agreement) with any person with respect to any of the Shares, granted any person any proxy (revocable or
irrevocable) or power of attorney with respect to any of the Shares, deposited any of the Shares in a voting trust or entered into any arrangement or agreement with any person limiting or affecting
Stockholder's legal power, authority or right to vote the Shares on any matter (except, in each case, with respect to the Voting Agreement and the Voting Agreement). 



        (c)   The
execution and delivery of this Agreement and the performance by Stockholder of his, her or its agreements and obligations hereunder will not result in any breach or
violation of or be in conflict with or constitute a default under any term of any agreement, judgment, injunction, order, decree, law, regulation or arrangement to which Stockholder is a party and
which Stockholder is aware or by which Stockholder (or any of his, her or its assets) is bound and which Stockholder is aware, except for any such breach, violation, conflict or default which,
individually or in the aggregate, would not materially impair or materially adversely affect Stockholder's ability to perform his, her or its obligations under this Agreement or render inaccurate any
of the representations made by Stockholder herein. 


        (d)   Stockholder
understands and acknowledges that Public Company, the Transitory Subsidiary and Merger Partner are entering into the Merger Agreement in reliance upon
Stockholder's execution and delivery of this Agreement and the representations and warranties of Stockholder contained herein. 




        8.    Confidentiality.    Stockholder recognizes that successful consummation of the Proposed Transaction may be
dependent upon confidentiality with respect to the matters referred to herein. In this connection, pending public disclosure thereof, and so that Public Company may rely on the safe harbor provisions
of Rule 100(b)(2)(ii) of Regulation FD promulgated under the Exchange Act, Stockholder hereby agrees not to disclose or discuss such matters with anyone not a party to this Agreement
(other than its counsel and advisors, if any, and the officers, directors, counsel and advisors of Public Company) without the prior written consent of Public Company and Merger Partner, except for
disclosures Stockholder's counsel advises are required by applicable law, in which case Stockholder shall give notice of such disclosure to Public Company and Merger Partner as promptly as practicable
so as to enable Public Company and Merger Partner to seek a protective order from a court of competent jurisdiction with respect thereto. The parties understand and agree that to the extent required
by law Stockholder may make a filing on Schedule 13D (or an amended filing) concerning this Agreement and that such filing will not constitute a violation of this Section 8. 


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        9.    Termination.    This Agreement, including without limitation, Section 4, shall terminate and be of no
further force or effect whatsoever as of the earliest of (a) such date and time as the Merger Agreement shall have been validly terminated pursuant to the terms of Article 9 thereof,
(b) the Effective Time and (c) June 30, 2009 (the "Expiration Date"). 


        10.    Miscellaneous Provisions.    



        (a)    Amendments, Modifications and Waivers.    This Agreement may not be amended or modified except by an instrument
in writing signed on behalf of each of the parties hereto. Any agreement on the part of a party hereto to any waiver of any term or condition hereof shall be valid only if set forth in a written
instrument signed on behalf of such party. Such waiver shall not be deemed to apply to any term or condition other than that which is specified in such waiver. The failure of any party to this
Agreement to assert any of its rights under this Agreement or otherwise shall not constitute a waiver of such rights. 


        (b)    Entire Agreement.    This Agreement constitutes the entire agreement among the parties to this Agreement and
supersedes any prior understandings, agreements or representations by or among the parties hereto, or any of them, written or oral, with respect to the subject matter hereof. 



        (c)    Governing Law.    All matters arising out of or relating to this Agreement and the transactions contemplated
hereby (including without limitation its interpretation, construction, performance and enforcement) shall be governed by and construed in accordance with the internal laws of the State of Delaware
without giving effect to any choice or conflict of law provision or rule (whether of the State of Delaware or any other jurisdiction) that would cause the application of laws of any jurisdictions
other than those of the State of Delaware. 


        (d)    Submission to Jurisdiction.    Each of the parties to this Agreement (i) consents to submit itself to
the exclusive personal jurisdiction of the Court of Chancery of the State of Delaware in any action or proceeding arising out of or relating to this Agreement or any of the transactions contemplated
by this Agreement, (ii) agrees that all claims in respect of such action or proceeding may be heard and determined in such court, (iii) agrees that it shall not attempt to deny or defeat
such personal jurisdiction by motion or other request for leave from such court and (d) agrees not to bring any action or proceeding arising out of or relating to this Agreement or any of the
transaction contemplated by this Agreement in any other court. Each of the parties hereto waives any defense of inconvenient forum to the maintenance of any action or proceeding so brought and waives
any bond, surety or other security that might be required of any other party with respect thereto. Any party may make service on another party by sending or delivering a copy of the process to the
party to be served at the address
and in the manner provided for the giving of notices in Section 10(m) hereof. Nothing in this Section 10(d), however, shall affect the right of any party to serve legal process in any
other manner permitted by law. 


        (e)    WAIVER OF JURY TRIAL.    EACH OF THE PARTIES HERETO HEREBY IRREVOCABLY WAIVES ALL RIGHT TO TRIAL BY JURY IN ANY
ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THE ACTIONS OF ANY PARTY IN
THE NEGOTIATION, ADMINISTRATION, PERFORMANCE AND ENFORCEMENT OF THIS AGREEMENT. 


        (f)    Attorneys' Fees.    In any action at law or suit in equity to enforce this Agreement or the rights of any of
the parties hereunder, the prevailing party in such action or suit shall be entitled to receive its reasonable attorneys' fees and all other reasonable costs and expenses incurred in such action or
suit. 



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        (g)    Assignment and Successors.    Except for any Transfer made in compliance with Section 2(a) hereof, no
party may assign any of its rights or delegate any of its performance obligations under this Agreement, in whole or in part, by operation of law or otherwise without the prior written consent of the
other parties, except that Merger Partner, without obtaining the consent of any other parties hereto, shall be entitled to assign this Agreement or all or any of its rights or obligations hereunder to
any one or more of its Affiliates. No assignment by Merger Partner under this Section 10(g) shall relieve Merger Partner of its obligations under this Agreement. Subject to the foregoing, this
Agreement shall be binding upon, inure to the benefit of, and be enforceable by, the parties hereto and their respective successors and permitted assigns, including, without limitation, Stockholder's
estate and heirs upon the death of Stockholder. Any purported assignment of rights or delegation of performance obligations in violation of this Section 10(g) shall be null and void. 


        (h)    No Third Party Beneficiaries.    This Agreement is not intended, and shall not be deemed, to confer any rights
or remedies upon any person other than the parties hereto and their respective successors and permitted assigns, or to otherwise create any third-party beneficiary hereto. 


        (i)    Cooperation.    Stockholder agrees to cooperate fully with Merger Partner and to execute and deliver such
further documents, certificates, agreements and instruments and to take such other actions as may be reasonably requested by Merger Partner to evidence or reflect the transactions contemplated by this
Agreement and to carry out the intent and purpose of this Agreement. Stockholder hereby agrees that Public Company and Merger Partner may publish and disclose in the Registration Statement and any
resale registration statement relating thereto (including all documents and schedules filed with the
SEC) and the Proxy Statement/Prospectus, such Stockholder's identity and ownership of Shares and the nature of such Stockholder's commitments, arrangements and understandings under this Agreement and
may further file this Agreement as an exhibit to the Registration Statement or in any other filing made by Public Company or Merger Partner with the SEC relating to the Proposed Transaction. 


        (j)    Severability.    Any term or provision of this Agreement that is invalid or unenforceable in any situation in
any jurisdiction shall not affect the validity or enforceability of the remaining terms and provisions hereof or the validity or enforceability of the offending term or provision in any other
situation or in any other jurisdiction. If the final judgment of a court of competent jurisdiction declares that any term or provision hereof is invalid or unenforceable, the parties hereto agree that
the court making such determination shall have the power to limit the term or provision, to delete specific words or phrases, or to replace any invalid or unenforceable term or provision with a term
or provision that is valid and enforceable and that comes closest to expressing the intention of the invalid or unenforceable term or provision, and this Agreement shall be enforceable as so modified.
In the event such court does not exercise the power granted to it in the prior sentence, the parties hereto agree to replace such invalid or unenforceable term or provision with a valid and
enforceable term or provision that will achieve, to the extent possible, the economic, business and other purposes of such invalid or unenforceable term. 



        (k)    Time of Essence.    With regard to all dates and time periods set forth or referred to in this Agreement, time
is of the essence. 


        (l)    Specific Performance; Injunctive Relief.    The parties hereto acknowledge that Public Company and Merger
Partner shall be irreparably harmed and that there shall be no adequate remedy at law for a violation of any of the covenants or agreements of Stockholder set forth in this Agreement. Stockholder
accordingly agrees that, in addition to any other remedies that may be available to Public Company or Merger Partner, as applicable upon any such violation, such party shall have the right to enforce
such covenants and agreements by specific performance, 



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injunctive
relief or by any other means available to such party at law or in equity without posting any bond or other undertaking. 


        (m)    Notices.    All notices and other communications hereunder shall be in writing and shall be deemed duly
delivered (i) four business days after being sent by registered or certified mail, return receipt requested, postage prepaid, or (ii) one business day after being sent for next business
day delivery, fees prepaid, via a reputable nationwide overnight courier service, in each case to the intended recipient as follows: (A) if to Public Company or Merger Partner, to the address
provided in the Merger Agreement, including to the persons designated therein to receive copies, and (B) if to Stockholder, to Stockholder's address shown below Stockholder's signature on the
signature page hereof. 


        (n)    Counterparts and Signature.    This Agreement may be executed in two or more counterparts, each of which shall
be deemed an original but all of which together shall be considered one and the same agreement and shall become effective when counterparts have been signed by each of the parties hereto and delivered
to the other parties, it being understood that all parties need not sign the same counterpart. The exchange of copies of this Agreement of amendments thereto and of signature pages by facsimile
transmission or by email transmission in portable document format, or similar format, shall constitute effective execution and delivery of such instrument(s) as to the parties and may be used in lieu
of the original Agreement for all purposes. Signatures of the parties transmitted by facsimile or by email transmission in portable document format, or similar format, shall be deemed to be their
original signatures for all purposes. 


        (o)    Headings.    The headings contained in this Agreement are for convenience of reference only and shall not
affect in any way the meaning or interpretation of this Agreement. 


        (p)    Legal Representation.    This Agreement was negotiated by the parties with the benefit of legal representation
and any rule of construction or interpretation otherwise requiring this Agreement to be construed or interpreted against any party shall not apply to any construction or interpretation thereof. 



        (q)    Termination of JHP and Archemix Agreements.    The Public Company represents to the Stockholder that on the
date hereof, each of (i) the Asset Purchase Agreement dated as of October 22, 2008 by and between the Public Company and JHP Pharmaceuticals, LLP and (ii) the Agreement and
Plan of Merger dated as of November 18, 2008 by and among the Public Company, Newport Acquisition Corp. and Archemix Corp. has been terminated in accordance with its terms. 



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        IN WITNESS WHEREOF, the undersigned have caused this Agreement to be duly executed as of the date first written above. 





					
	 DEERFIELD PRIVATE DESIGN FUND, L.P.	 	STOCKHOLDER:
	
 By:	
 	
  







 	
 	







  
	Name: James E. Flynn

Title: General Partner	 	Name:

Title:






 







 



					
	 DEERFIELD PRIVATE DESIGN

INTERNATIONAL, L.P.	 	

Address:
	
 By:	
 	
  







 	
 	
    







 
	Name: James E. Flynn	 	





  
	Title: General Partner	 	






  






 






 



					
	 DEERFIELD SPECIAL SITUATIONS FUND, L.P.	 	Telephone:  (      )       -            

Facsimile:  (      )       -            

E-Mail
Address:                                        
              
	By:	 	  







 	 	 
	Name: James E. Flynn

Title: General Partner	 	 






 







 



					
	 DEERFIELD SPECIAL SITUATIONS FUND INTERNATIONAL LIMITED	 	

Shares Beneficially Owned by Stockholder:
	
 By:	
 	
  







 	
 	
                   shares of Public Company Common Stock
	Name: James E. Flynn

Title: General Partner	 	                   Public Company Stock Options






 







 



					
	 NTMD PARENT ACQUISITION CORP.	 	 
	
 By:	
 	
  







 	
 	

 
	Name:

Title:	 	 	 	 






With
respect to Section 2(b) only: 





					
	 NITROMED, INC.:	 	 
	
  






  Name:

Title:	
 	

 





[Signature Page to Merger Partner Stockholder Agreement] 







Signatories
to Stockholder Voting Agreements 


	1.
	Deerfield
Special Situations Fund, L.P.  
	2.
	Deerfield
Special Situations Fund International Limited  
	3.
	HealthCare
Ventures V, LP  
	4.
	HealthCare
Ventures VI, LP 


[Signature Page to Merger Partner Stockholder Agreement] 











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Exhibit 10.1