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        Guidance Documents & Regulatory Information by Topic (Food and Dietary Supplements)

Chemical, Metals, Natural Toxins & Pesticides Guidance Documents & Regulations Home
          Food
          Guidance & Regulation (Food and Dietary Supplements)
          Guidance Documents & Regulatory Information by Topic (Food and Dietary Supplements)
          Chemical, Metals, Natural Toxins & Pesticides Guidance Documents & RegulationsGuidance Documents & Regulatory Information by Topic (Food and Dietary Supplements) Chemical, Metals, Natural Toxins & Pesticides Guidance Documents & Regulations
  	
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For additional information, see the Chemicals, Metals & Pesticides in Food section.

Chemical

**Acrylamide:**Guidance for Industry: Acrylamide in Foods (March 2016)
	**Dioxins & PCBs:**Guidance for Industry: Possible Dioxin/PCB Contamination of Drug and Biological Products (PDF - 7.7KB) (August 1999)
	**Melamine:**"Dear Colleague" Letter to the United States Food Manufacturing Industry, Regarding Melamine (October 10, 2008)
	**Radionuclides**
	Compliance Policy Guide: Guidance Levels for Radionuclides in Domestic and Imported Foods (July 29, 2004)
		Supporting Document for Guidance Levels for Radionuclides in Domestic and Imported Foods (July 29, 2004)
	Action Levels for Poisonous or Deleterious Substances in Human Food and Animal Feed (2000)Metals

**Arsenic**

	Guidance for Industry: Inorganic Arsenic in Apple Juice - Action Level (June 2023)
		Guidance for Industry: Inorganic Arsenic in Rice Cereals for Infants: Action Level (August 2020)
		Small Entity Compliance Guide: Bottled Water and Arsenic (April 2009)
	**Lead**
	Draft Guidance for Industry: Action Levels for Lead in Food Intended for Babies and Young Children (January 2023)
		Draft Guidance for Industry: Action Levels for Lead in Juice (April 2022) 
		Draft Supporting Document for Establishing FDA’s Action Levels for Lead in Juice (April 2022)
		Guidance for Industry: The Safety of Imported Traditional Pottery Intended for Use with Food and the Use of the Term “Lead Free” in the Labeling of Pottery; and Proper Identification of Ornamental and Decorative Ceramicware (November 2010)
		WITHDRAWN - Chemical Contaminants (Lead): 1991 Letter to Bureau of Alcohol, Tobacco and Firearms Regarding Lead in Wine (March 2007)*See**Letter Concerning the Withdrawal of "1991 Letter to Bureau of Alcohol, Tobacco and Firearms Regarding Lead in Wine"**from January 2017*
		Lead in Candy Likely To Be Consumed Frequently by Small Children: Recommended Maximum Level and Enforcement Policy (November 2006)
		Supporting Document for Recommended Maximum Level for Lead in Candy Likely To Be Consumed Frequently by Small Children (November 2006)
		Letter to Manufacturers, Importers, and Distributors of Imported Candy and Candy Wrappers (June 13, 1995)Natural Toxins

Compliance Policy Guide Sec. 550.050 Canned Ackee, Frozen Ackee, and Other Ackee Products- Hypoglycin A Toxin (PDF - 30KB) (April 14, 2014)
	Guidance for Industry and FDA: Advisory Levels for Deoxynivalenol (DON) in Finished Wheat Products for Human Consumption and Grains and Grain By-Products used for Animal Feed (June 2010)
	Guidance for Industry: Fumonisin Levels in Human Foods and Animal Feeds (November 9, 2001)
	Compliance Policy Guide Sec. 555.400 Foods - Adulteration with Aflatoxin
	Compliance Policy Guide Sec. 570.200 Brazil Nuts - Adulteration with Aflatoxin
	Compliance Policy Guide Sec. 570.500 Pistachio Nuts - Aflatoxin Adulteration
	Compliance Policy Guide Sec. 570.375 Aflatoxin in Peanuts and Peanut Products
	Compliance Policy Guide for FDA Staff: Sec. 550.050 Canned Ackee, Frozen Ackee, and Other Ackee Products - Hypoglycin A Toxin
	Compliance Policy Guidance for FDA Staff: Apple Juice, Apple Juice Concentrates, and Apple Juice Products - Adulteration with PatulinPesticides

**Chlorpyrifos:** Questions and Answers Regarding Channels of Trade Policy for Human Food Commodities with Chlorpyrifos Residues (February 2022)
	**Pesticide Chemicals:** Channels of Trade Policy for Commodities With Residues of Pesticide Chemicals, for Which Tolerances Have Been Revoked, Suspended, or Modified by the Environmental Protection Agency Pursuant to Dietary Risk Considerations (May 2005)
	**Methyl Parathion:** Channels of Trade Policy for Commodities with Methyl Parathion Residues (December 2000)
	**Vinclozolin:** Channels of Trade Policy for Commodities with Vinclozolin Residues (June 12, 2002)See ***Bottled Water & Carbonated Soft Drinks Guidance Documents & Regulatory Information*** for additional guidance and regulations.

                                                                                  Content current as of:
      06/01/2023
                  
                   
Regulated Product(s)
		 Food & BeveragesChemical, Metals, Natural Toxins & Pesticides Guidance Documents & Regulations
 
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