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        Drug Safety and Availability

Multistate outbreak of fungal meningitis and other infections Home
          Drugs
          Drug Safety and Availability
          Multistate outbreak of fungal meningitis and other infectionsDrug Safety and Availability Multistate outbreak of fungal meningitis and other infections
  	
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**[12-12-2012]**FDA and CDC have identified bacterial and/or fungal contamination in unopened vials of betamethasone, cardioplegia, and triamcinolone solutions distributed and recalled from NECC. These include bacteria known as *Bacillus*, and fungal species including *Aspergillus tubingensis,  Aspergillus fumigatus,  Cladosporium*species,and*Penicillium*species.  Although rare, some of the identified *Bacillus* species can be human pathogens.  Some of the fungal organisms identified, particularly *Aspergillus fumigatus*, are known to cause disease in humans.  It is not known how product contamination with these organisms could affect patients clinically.  See CDC’s Advice for Clinicians.

**CDC and FDA Laboratory-Confirmed Organisms from Product Samples**

**Laboratory-Confirmed Organisms from Product Samples Associated with
NECC Recalled Lots of Betamethasone, Cardioplegia, and Triamcinolone Solutions**

Medication
			Lot Number
			Bacterial and Fungal ContaminationBetamethasone
			6 mg/mL injectable –5 mL per vial
			08202012@141
			*Paenibacillus pabuli/amolyticus, Bacillus idriensis, Bacillus flexus, Bacillus simplex, Lysinibacillus* sp., *Bacillus niacini, Kocuria rosea,
			Bacillus lentus*Betamethasone
			6 mg/mL injectable –5 mL per vial
			07032012@22
			*Bacillus niabensis, Bacillus circulans*Betamethasone
			12 mg/mL injectable – 5 mL per vial
			07302012@52
			*Bacillus lentus, Bacillus circulans, Bacillus niabensis, Paenibacillus barengoltzii/timonensis*Betamethasone
			6mg/mL injectable – 5 mL per vial
			08202012@44
			*Bacillus lentus, Bacillus firmus, Bacillus pumilus*Betamethasone
			6 mg/mL injectable – 5 mL per vial
			08152012@84
			*Penicillium*sp*.,* *Cladosporium*sp.Triamcinolone
			40mg/mL injectable – 1 mL per vial
			06062012@6
			*Bacillus lentus, Bacillus circulans, Bacillus niabensis, Bacillus nealsonii, Bacillus subtilis group, Bacillus firmus*Triamcinolone
			40 mg/mL injectable – 2 mL per vial
			08172012@60
			*Aspergillus tubingensis,* *Penicillium*sp.Triamcinolone
			40mg/mL injectable – 10 mL per vial
			08242012@2
			*Aspergillus fumigatus*Cardioplegia solution
			265.5 mL per bag
			09242012@55
			*Bacillus halmapalus/horikoshii, Brevibacillus choshinensis*



Related Information

FDA Form 483 for New England Compounding Center
	Meningitis Outbreak: Voriconazole IV availability informationResources

Patient Notification Letter
	FDA Voice: We're Working to Offset Ameridose Impact
	FDA Voice: State and Local Partnerships Are CrucialNECC Information

New England Compounding Center (NECC) Customer List Since 5/21/2012, Sorted by State - No Product Information
	New England Compounding Center (NECC) Customer List Since 5/21/2012, Sorted by Customer - With Product InformationCDC Information

Fungal Meningitis Outbreak Infographic (CDC)
	Multi-State Meningitis Outbreak (CDC)

                                                                                  Content current as of:
      11/01/2016Multistate outbreak of fungal meningitis and other infections
 
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