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          Sickle Cell DiseaseMinority Health and Health Equity Resources Sickle Cell Disease
  
  	
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Sickle cell disease is an inherited blood disorder that can cause anemia, severe pain, infections, organ damage, and stroke. It is a lifelong condition that primarily affects Black/African American and Hispanic/Latino populations.

What is sickle cell disease?

Healthy red blood cells are flexible and travel through your blood vessels to carry oxygen to your tissues. Sickle cell disease (SCD) is caused by a genetic mutation that changes the shape of red blood cells from round to C-shaped like a farm tool called a sickle. Sickled red blood cells are stiff and sticky and can get stuck in blood vessels and clog the blood flow, preventing oxygen from getting to parts of the body. This blockage can cause pain.

Who is affected by sickle cell disease?

Sickle cell disease is the most commonly inherited blood disorder in the United States. About 1 out of every 400 Black or African Americans and about 1 out of every 16,000 Hispanic/Latino Americans are born with SCD.

What are the symptoms of sickle cell disease?

The symptoms and complications of SCD vary in severity from person to person and may change over time. Early symptoms usually develop around 5 months of age and may include:

Painful swelling of the hands and feet (dactylitis)
	Fatigue or fussiness from a shortage of oxygen in the blood (anemia)
	Yellowish color of the skin (jaundice) or in the white parts of the eye (icterus)Adults and children living with SCD often experience pain crises, which are the most common cause of hospitalization. Sickle cell disease raises the risk of acute chest syndrome, infections, heart and kidney damage, and stroke.

How is sickle cell disease diagnosed?

Since 2006, all U.S. states require newborn screening for SCD using a blood test. Adults can get screened to identify sickle cell trait (SCT), which is when a person carries the gene for SCD. Your health care provider can estimate your chances of passing the gene to your children.

How is sickle cell disease treated?

Patients may use pain medications to manage pain crises. Blood transfusions (receiving healthy blood from a donor) can help prevent complications or treat severe anemia. Four FDA-approved medications may help prevent the common complications of SCD in children and adults:

Hydroxyurea
	L-glutamine oral powder
	Voxelotor
	Crizanlizumab-tmcaConsult with your health care provider to find out if any of these medications are right for you or your child.

The only cure for SCD is a bone marrow or stem cell transplant. Younger patients with severe SCD can consider transplants, but they are expensive, require a matching donor, and have serious risks.

Sickle cell disease and clinical trials

The FDA encourages diverse participation in clinical trials. If you think a clinical trial may be right for you, talk to your health care provider. You can also search for clinical trials in your area at **www.ClinicalTrials.gov**.

For more information on health equity, visit **www.fda.gov/healthequity**.

Download Sickle Cell Disease Resources

Fact Sheet: Sickle Cell Disease
	Brochure: Sickle Cell Disease and What You Need To Know
	Infographic: What Is Sickle Cell Disease?

                                                                                  Content current as of:
      05/04/2022
              
              
Health Topic(s)
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			    			       			    			       Sickle Cell DiseaseMinority Health and Health Equity Resources

          
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