Exhibit 4.25

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SHARE AND ASSET PURCHASE AGREEMENT

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Among

CENTERPULSE (UK) HOLDINGS LTD.,

CENTERPULSE USA HOLDING CO.,

CENTERPULSE GERMANY HOLDING GmbH,

CENTERPULSE AG

and

TERUMO CORPORATION

Dated as of October 3, 2002

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TABLE OF CONTENTS

|            |              |                                          |                                                    | Page
|----------- | ------------ | ---------------------------------------- | -------------------------------------------------- | ----
|ARTICLE I   |              | DEFINITIONS                              |                                                    | 1   
|            | Section 1.01 |                                          | Certain Defined Terms                              |     
|            | Section 1.02 |                                          | Other Defined Terms                                |     
|            | Section 1.03 |                                          | Miscellaneous                                      |     
|ARTICLE II  |              | PURCHASE AND SALE                        |                                                    | 6   
|            | Section 2.01 |                                          | Purchase and Sale of the Shares                    |     
|            | Section 2.02 |                                          | Purchase and Sale of the Assets                    |     
|            | Section 2.03 |                                          | Purchase Price; Purchase Price Allocation          |     
|            | Section 2.04 |                                          | Closing                                            |     
|            | Section 2.05 |                                          | Foreign Closings                                   |     
|            | Section 2.06 |                                          | Closing Deliveries by Seller                       |     
|            | Section 2.07 |                                          | Closing Deliveries by Purchaser                    |     
|            | Section 2.08 |                                          | Adjustment of Purchase Price                       |     
|ARTICLE III |              | REPRESENTATIONS AND WARRANTIES OF SELLER |                                                    | 10  
|            | Section 3.01 |                                          | Incorporation and Authority of Seller              |     
|            | Section 3.02 |                                          | Incorporation of the Target Companies              |     
|            | Section 3.03 |                                          | Share Capital of Target Companies; No Subsidiaries |     
|            | Section 3.04 |                                          | Sufficiency of Assets                              |     
|            | Section 3.05 |                                          | No Conflict                                        |     
|            | Section 3.06 |                                          | Consents and Approvals                             |     
|            | Section 3.07 |                                          | Financial Information                              |     
|            | Section 3.08 |                                          | Absence of Undisclosed Liabilities                 |     
|            | Section 3.09 |                                          | Absence of Certain Changes or Events               |     
|            | Section 3.10 |                                          | Fair Trading                                       |     
|            | Section 3.11 |                                          | Litigation                                         |     
|            | Section 3.12 |                                          | Compliance with Laws; Certain Regulatory Matters   |     
|            | Section 3.13 |                                          | Licenses and Permits                               |     
|            | Section 3.14 |                                          | Environmental Matters                              |     
|            | Section 3.15 |                                          | Books and Records                                  |     
|            | Section 3.16 |                                          | Grants                                             |     
|            | Section 3.17 |                                          | Condition and Use of Fixed Assets                  |     
|            | Section 3.18 |                                          | Intellectual Property Rights                       |     
|            | Section 3.19 |                                          | Material Contracts                                 |     
|            | Section 3.20 |                                          | Insurances                                         |     
|            | Section 3.21 |                                          | Real Property                                      |     

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|           | Section 3.22 |                                             | Employees and Workers                                                                           |    | 17
|---------- | ------------ | ------------------------------------------- | ----------------------------------------------------------------------------------------------- | -- | --
|           | Section 3.23 |                                             | Employee Benefit MattersU.K.                                                                   |    | 18
|           | Section 3.24 |                                             | Employee Benefit MattersU.S.                                                                   |    | 18
|           | Section 3.25 |                                             | Taxes                                                                                           |    | 19
|           | Section 3.26 |                                             | Solvency                                                                                        |    | 19
|           | Section 3.27 |                                             | Brokers                                                                                         |    | 19
|           | Section 3.28 |                                             | No Implied Representations and Warranties                                                       |    | 19
|           | Section 3.29 |                                             | JLL Contract                                                                                    |    | 20
|           | Section 3.30 |                                             | Inventory                                                                                       |    | 20
|           | Section 3.31 |                                             | Product Liability                                                                               |    | 20
|           | Section 3.32 |                                             | Notice of Developments                                                                          |    | 20
|           | Section 3.33 |                                             | Computer Systems                                                                                |    | 21
|ARTICLE IV |              | REPRESENTATIONS AND WARRANTIES OF PURCHASER |                                                                                                 | 21
|           | Section 4.01 |                                             | Incorporation and Authority of Purchaser                                                        |    | 21
|           | Section 4.02 |                                             | No Conflict                                                                                     |    | 21
|           | Section 4.03 |                                             | Consents and Approvals                                                                          |    | 21
|           | Section 4.04 |                                             | Litigation                                                                                      |    | 21
|           | Section 4.05 |                                             | Investment Purpose                                                                              |    | 22
|           | Section 4.06 |                                             | Financing                                                                                       |    | 22
|           | Section 4.07 |                                             | Brokers                                                                                         |    | 22
|ARTICLE V  |              | ADDITIONAL AGREEMENTS                       |                                                                                                 | 22
|           | Section 5.01 |                                             | Conduct of Business Prior to the Closing                                                        |    | 22
|           | Section 5.02 |                                             | Investigation; Confidentiality                                                                  |    | 23
|           | Section 5.03 |                                             | Access to Information                                                                           |    | 24
|           | Section 5.04 |                                             | Books and Records                                                                               |    | 25
|           | Section 5.05 |                                             | Satisfaction of Conditions Precedent; Regulatory and Other Authorizations; Notices and Consents |    | 25
|           | Section 5.06 |                                             | Notification to Governmental Authorities                                                        |    | 26
|           | Section 5.07 |                                             | Non-Competition                                                                                 |    | 26
|           | Section 5.08 |                                             | Intercompany Arrangements                                                                       |    | 27
|           | Section 5.09 |                                             | Insurance Coverage                                                                              |    | 27
|           | Section 5.10 |                                             | Transition Services                                                                             |    | 27
|           | Section 5.11 |                                             | Continued Grafts Employees                                                                      |    | 27
|           | Section 5.12 |                                             | Further Action                                                                                  |    | 27
|           | Section 5.13 |                                             | German Newco                                                                                    |    | 27
|ARTICLE VI |              | EMPLOYEE MATTERS                            |                                                                                                 | 28
|           | Section 6.01 |                                             | Continuation of BenefitsTarget Companies                                                       |    | 28
|           | Section 6.02 |                                             | Employment of Continued Grafts Employees                                                        |    | 28

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|             | Section 6.03  |                        | Cash Compensation                          |    | 28
|------------ | ------------- | ---------------------- | ------------------------------------------ | -- | --
|             | Section 6.04  |                        | Severance                                  |    | 28
|             | Section 6.05  |                        | Pension Schemes                            |    | 28
|             | Section 6.06  |                        | 401(k) Plan                                |    | 28
|             | Section 6.07  |                        | Purchaser Plans                            |    | 29
|             | Section 6.08  |                        | Retention Bonuses                          |    | 29
|ARTICLE VII  |               | CONDITIONS TO CLOSING  |                                            | 29
|             | Section 7.01  |                        | Conditions to Obligations of Seller        |    | 29
|             | Section 7.02  |                        | Conditions to Obligations of Purchaser     |    | 30
|ARTICLE VIII |               | INDEMNIFICATION        |                                            | 30
|             | Section 8.01  |                        | Survival of Representations and Warranties |    | 30
|             | Section 8.02  |                        | Indemnification by Purchaser               |    | 30
|             | Section 8.03  |                        | Indemnification by Seller                  |    | 32
|ARTICLE IX   |               | TERMINATION AND WAIVER |                                            | 34
|             | Section 9.01  |                        | Termination                                |    | 34
|             | Section 9.02  |                        | Effect of Termination                      |    | 34
|             | Section 9.03  |                        | Waiver                                     |    | 35
|ARTICLE X    |               | GENERAL PROVISIONS     |                                            | 35
|             | Section 10.01 |                        | Expense                                    |    | 35
|             | Section 10.02 |                        | Notices                                    |    | 35
|             | Section 10.03 |                        | Public Announcements                       |    | 36
|             | Section 10.04 |                        | Headings                                   |    | 36
|             | Section 10.05 |                        | Severability                               |    | 36
|             | Section 10.06 |                        | Entire Agreement                           |    | 36
|             | Section 10.07 |                        | Assignment; Fulfillment of Obligations     |    | 36
|             | Section 10.08 |                        | No Third Party Beneficiaries               |    | 37
|             | Section 10.09 |                        | Amendment                                  |    | 37
|             | Section 10.10 |                        | Rights Cumulative and Other Matters        |    | 37
|             | Section 10.11 |                        | Governing Law                              |    | 37
|             | Section 10.12 |                        | Counterparts                               |    | 37
|             | Section 10.13 |                        | Disclosure Letter                          |    | 37
|             | Section 10.14 |                        | Currency                                   |    | 37
|             | Section 10.15 |                        | Specific Performance                       |    | 37

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SHARE AND ASSET PURCHASE AGREEMENT, dated as of October 3, 2002, among CENTERPULSE (U.K.) HOLDING LIMITED, a company organized under the laws of Scotland
("Seller"), CENTERPULSE USA HOLDING CO., a Delaware corporation ("CUH"), CENTERPULSE GERMANY HOLDING
GmbH, a company organized under the laws of Germany ("CGHG") CENTERPULSE AG, a company organized under the laws of Switzerland, and TERUMO CORPORATION,
a corporation organized under the laws of Japan ("Purchaser").

W I T N E S S E T H:

WHEREAS, Seller, through its wholly owned subsidiary, affiliated companies and related companies, agencies and distributors is engaged in the design, manufacture,
marketing, sale and distribution of vascular graft products (the "Grafts Business");

WHEREAS,
Seller wishes to sell to Purchaser, and Purchaser wishes to purchase from Seller, the Grafts Business, upon the terms and conditions set forth herein;

WHEREAS,
as part of the sale of the Grafts Business by Seller and the purchase of the Grafts Business by Purchaser hereunder, Seller, CUH and CGHG will sell to Purchaser the entire
issued share capital of or the outstanding shares of capital stock, as the case may be (collectively, the "Shares") of (i) Vascutek Limited, a
company incorporated under the laws of Scotland ("VAK"), (ii) Sulzer Vascutek USA Inc., a Delaware corporation
("VAKUS"), (iii) a new company organized under the laws of Germany (to be incorporated following the execution of this Agreement and prior to
Closing) and which is to own that part of the Grafts Business which at the date of this Agreement is owned by Sulzer Cardiovascular GmbH ("CVD") (VAKUS
and CVD being the "Affiliated Companies" and, together with VAK, the "Target Companies"); and

WHEREAS,
as part of the sale of the Grafts Business by Seller and the purchase of the Grafts Business by Purchaser hereunder, Seller will cause to be sold to Purchaser certain assets of
the Grafts Business held by certain related companies set forth on the Schedule of Related Companies hereto (the "Related Companies").

NOW,
THEREFORE, in consideration of the premises and the mutual agreements and covenants hereinafter set forth, Seller and Purchaser hereby agree as follows:

ARTICLE IDEFINITIONS

Section 1.01Certain Defined Terms.As used in this Agreement, the following terms shall have the
following meanings:

"Action" means any claim, action, suit, arbitration, inquiry, proceeding or investigation by or before any Governmental Authority.

"Affiliate" means, with respect to any specified Person, any other Person that directly, or indirectly through one or more intermediaries,
controls, is controlled by, or is under common control with, such specified Person.

"Agreement" or "this Agreement" means this Share and Asset Purchase Agreement, dated as of
October 3, 2002, among Seller, CUH, CGHG, Centerpulse AG, and Purchaser (including the Schedules, the Tax Deed and the Disclosure Letter) and all amendments hereto made in accordance with the
provisions hereof.

"Balance Sheet Date" means the date of the Reference Balance Sheet.

"Business Day" means any day that is not a Saturday, a Sunday or other day on which banks are required or authorized by Law to be closed
in New York, New York, Tokyo, Japan or London, England.

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"Bylaws" means the bylaws of any corporation organized under the law of any State of the United States of America and any equivalent
document of any corporation or entity organized under the laws of another jurisdiction, as amended or restated through the date hereof or the Closing Date, as the case may be.

"Charter" means the Certificate of Incorporation or Formation, Articles of Incorporation or Organization or other organizational document
of a corporation or limited liability company organized under the laws of any State of the United States of America and any equivalent document of a corporation, limited liability company or other
similar entity organized under the laws of another jurisdiction, as amended or restated through the date hereof or the Closing Date, as the case may be.

"Clinical Application Research Studies" means post-approval clinical studies of market-released products that do not require
an Investigational Device Exemption from the FDA.

"Closing Balance Sheet" means the Grafts Business balance sheet (including the related notes and schedules thereto), to be prepared
pursuant to Section 2.08(a) and to be dated as of the Closing Date.

"Code" means the Internal Revenue Code of 1986, as amended.

"Continued Grafts Employees" means employees of a Related Company who service the Grafts Business and who are to be employed by Purchaser
or its designee as of the Closing, all of whom are listed on Section 6.02 of the Disclosure Letter.

"Continuing Directors" means those directors of the Target Companies who are remaining on the relevant board of directors after the
Closing Date.

"control" (including the terms "controlled by" and "under common
control with") means the possession, directly or indirectly or as trustee or executor, of the power to direct or cause the direction of the management and policies of a Person,
whether through the ownership of voting securities, as trustee or executor, by contract or credit agreement or otherwise.

"Disclosure Letter" means the First Disclosure Letter or the Second Disclosure Letter, as the case may be.

"Dollars" means U.S. Dollars.

"Encumbrance" means any security interest, pledge, mortgage, lien or encumbrance.

"Environmental Law" means any Law that regulates, establishes standards or requirements, or concerns liability with respect to the
environment, natural resources, safety, or health of humans or other organisms, including with respect to the manufacture, distribution in commerce and use of Hazardous Substances.

"ERISA" means the United States Employee Retirement Income Security Act of 1974, as amended.

"FDA" means the United States Food and Drug Administration.

"First Disclosure Letter" means the disclosure letter from Seller to Purchaser dated the date of this Agreement.

"German Sale Agreement" means the agreement to be entered into between CGHG and Purchaser (or such other person as Purchaser shall
nominate) in relation to the sale to Purchaser or its designee of the shares of CVD.

"Governmental Authority" means any government, governmental, regulatory or administrative authority, agency or commission or any court,
tribunal, or judicial, quasi-judicial or arbitral body.

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"Governmental Order" means any order, writ, judgment, injunction, decree, stipulation, determination or award entered by or with any
Governmental Authority.

"Hazardous Substance" means any toxic or hazardous substance or wastes, petroleum or petroleum products, asbestos or other pollutants, as
defined under applicable Environmental Laws.

"Indebtedness" means, with respect to any Person, (a) all indebtedness of such Person, whether or not contingent, for borrowed
money, (b) all obligations of such Person evidenced by notes, bonds, debentures or other similar instruments, (c) all indebtedness created or arising under any conditional
sale or other title retention agreement with respect to property acquired by such Person, (d) all obligations of such Person as lessee under leases that have been or should be, in accordance
with U.K. GAAP, recorded as capital leases, (e) all obligations, contingent or otherwise, of such Person under acceptance, letter of credit or similar facilities and (f) all Indebtedness
of others referred to in clauses (a) through (e) above guaranteed directly or indirectly by such Person.

"Intellectual Property" means (a) patents, patent registrations and patent applications and all rights therein,
(b) trademarks, service marks, trade dress, logos, whether or not registered, and registrations and applications for registration thereof, (c) copyrights (registered or otherwise) and
registrations and applications for registration thereof and (d) trade secrets and confidential, technical or business information including know-how, manufacturing and production
processes and techniques.

"JLL Contract" means the distribution agreement between VAK and Japan Lifeline Co. Ltd.

"Key Employees" means the individuals listed on Section 3.22(c) of the Disclosure Letter.

"Knowledge" means, with respect to Seller, the actual knowledge of Roshan Maini or Frank Carroll, and in addition with respect to
Section 3.18 of this Agreement only, Timothy Ashton and Kenneth Barrow.

"Law" means any federal, state, canton, provincial, local or national statute, law, ordinance, regulation, rule, code, order or other
requirement or rule of law.

"Material Adverse Effect" means any change in or effect which individually or in the aggregate with all other such changes and effects, is
materially adverse to the financial condition or to the results of operations of the Grafts Business taken as a whole, except for any such changes or effects resulting from (a) this Agreement
or the transactions contemplated hereby or the announcement thereof, (b) changes in general economic or political conditions or the securities markets or (c) changes, after the date of
this Agreement, in conditions generally applicable to Persons engaged in the design, manufacture, marketing, sale or distribution of medical devices of the nature designed, manufactured, marketed,
sold and distributed by the Target Companies and the Related Companies, including, without limitation, (i) changes in Laws (or interpretations thereof by any Governmental Authority) generally
applicable to such Persons and (ii) changes in U.K. GAAP or in international accounting standards.

"Medical Product Regulatory Authority" means any Governmental Authority that is concerned principally with the safety, efficacy,
reliability or manufacture of medical products.

"Nominated Account" means an account or accounts notified to Purchaser by Seller at least two Business Days prior to the Closing Date.

"Owned Intellectual Property" means all Intellectual Property in and to which any Target Company holds, or has a right to hold, right,
title and interest.

"Owned Real Property" means the real property owned by any Target Company, together with all buildings and other structures, facilities or
improvements currently or hereafter located thereon.

"Pension Schedule" means the pensions schedule attached to and forming part of this Agreement.

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"Permitted Encumbrances" means (a) liens for Taxes and assessments not yet payable, (b) liens for Taxes, assessments and
charges and other claims, the validity of which is being contested in good faith, (c) imperfections of title, liens, security interests and other encumbrances the existence of which,
individually and in the aggregate, do not interfere with the current use of the property encumbered thereby, (d) inchoate mechanics', materialmen's and similar liens for construction in
progress and (e) workmen's, repairmen's, warehousemen's and carriers' liens arising in the ordinary course of business.

"Person" means any individual, partnership, firm, corporation, limited liability company, association, trust, unincorporated organization
or other entity, as well as any syndicate or group that would be deemed to be a person under Section 13(d)(3) of the Securities Exchange Act of 1934, as amended.

"Pre-Closing Taxable Period" means (i) any Taxable period ending on or before the Closing Date and (ii) with
respect to any Straddle Period, the portion of such Taxable period that begins before the Closing Date and that includes the Closing Date.

"Second Disclosure Letter" means the disclosure letter from Seller to Purchaser to be dated the Closing Date.

"Seller Warranties" means the warranties set out in Article III of this Agreement.

"Straddle Period" means any Taxable period beginning before and ending after the Closing Date.

"Sulzer Orthopedics Settlement Arrangement" means the Class Action Settlement Agreement dated March 13, 2002 by and among Sulzer
Orthopedics, Inc., Sulzer Medica AG, Sulzer AG and Class Counsel on behalf of Class Representatives in re: Sulzer Hip Prosthesis and Knee Prosthesis Liability Litigation MDL Docket
No. 01-CV-9000 (MDL No. 1401), as the same may be amended from time to time.

"Tax" or "Taxes" means (a) all taxes, charges, fees, levies, duties, imposts or
other similar assessments, including income, capital gains, gross receipts, ad valorem, excise, real property, personal property, windfall profit, sales, use, transfer, stamp, licensing, withholding,
employment, payroll, minimum, estimated and franchise taxes imposed by any federal, state, canton, provincial, local or national government, or any subdivision, agency or other similar Person of any
such government and (b) any interest, fines, penalties, assessments or additions to tax resulting from, attributable to or incurred in connection with any such tax or taxes.

"Tax Deed" means the deed of indemnity substantially in the form attached hereto relating to Tax liabilities of the Target Companies.

"Tax Return" means any form, return or report of or relating to Taxes.

"Taxing Authority" means any federal, state, canton, provincial, local, national or other Governmental Authority of any jurisdiction
having the power to impose a Tax or Taxes.

"U.K. GAAP" means United Kingdom generally accepted accounting principles and practices as in effect from time to time and applied
consistently throughout the periods involved.

"Working Capital" of the Grafts Business as of any date means the Grafts Business' current assets minus the Grafts Business' current
liabilities (such current assets and current liabilities as indicated on the Reference Balance Sheet provided in Section 1.01 of the Disclosure Letter) and not including any accruals for
P.A.Y.E. or N.I.C.

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Section 1.02Other Defined Terms.The following terms shall have the meanings defined for such terms in
the Sections set forth below:

Term:

Section:401(k) Plan Participants

Section 6.06Affiliated Companies

RecitalsBase Purchase Price

Section 2.03CGHG

RecitalsClosing

Section 2.04Closing Date

Section 2.04Competitive Business

Section 5.07Confidentiality Agreement

Section 5.02CUH

RecitalsCVD

RecitalsDesignated Amount

Section 8.03Diversified Company

Section 5.07Foreign Agreements

Section 2.05Foreign Closing

Section 2.05Government Antitrust Authority

Section 5.05Grafts Business

RecitalsGrafts Business Financial Statements

Section 3.087Independent Accounting Firm

Section 2.08Lehman

Section 3.27Losses

Section 8.02Material Contracts

Section 3.19Non-Competition Period

Section 5.07Purchase Price

Section 2.03Purchaser

PreamblePurchaser Indemnified Party

Section 8.03Purchaser Plan

Section 6.06Purchaser Transition Services Agreement

Section 5.10Purchaser's Accountants

Section 2.08Reference Balance Sheet

Section 3.08Related Assets and Liabilities

Section 2.02Related Companies

RecitalsSeller

PreambleSeller 401(k) Plan

Section 6.06Seller Indemnified Party

Section 8.02Seller Transition Services Agreement

Section 5.10Seller's Accountants

Section 2.08Seller's Threshold Amount

Section 8.03Selling Entities

Section 3.01Shares

RecitalsTarget Companies

RecitalsTreaty

Section 3.10VAK

RecitalsVAKUS

RecitalsVAKUS Benefit Plans

Section 3.24


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Section 1.03Miscellaneous.In this Agreement, where the context admits:



ARTICLE IIPURCHASE AND SALE

Section 2.01Purchase and Sale of the Shares.Upon the terms and subject to the conditions of this
Agreement, at the Closing, Seller, CUH and CGHG shall, and shall cause the Persons who own of record any of the Shares to, sell, assign, transfer, convey and deliver the Shares to Purchaser, free and
clear of all Encumbrances, and with full title guarantee, and Purchaser shall purchase the Shares.

Section 2.02Purchase and Sale of the Assets.Upon the terms and subject to the conditions of this
Agreement, at the Closing, Seller shall cause the Related Companies to sell, assign, transfer, convey and deliver the assets and liabilities of the Grafts Business held by the Related Companies and to
be set forth on the Closing Balance Sheet hereto (collectively, the "Related Assets and Liabilities") to Purchaser or its designee, with the benefit of
full title guarantee in respect of owned assets, and Purchaser or its designee shall purchase and assume the Related Assets and Liabilities. Other than the Related Assets and Liabilities, no assets or
liabilities of the Related Companies are being sold, assigned, transferred or conveyed by the Related Companies pursuant to this Agreement, and
Purchaser or its designee is not purchasing or assuming any assets or liabilities other than the Related Assets and Liabilities.

Section 2.03Purchase Price; Purchase Price Allocation.(a) The aggregate purchase price for the
Shares and the Related Assets and Liabilities shall be $170,000,000 in cash (the "Base Purchase Price"), subject to adjustment as provided in
Section 2.08 (the Base Purchase Price, as so adjusted, being the "Purchase Price").

(b)  The
Purchase Price shall be allocated among the Shares and the Related Assets and Liabilities in accordance with Schedule 2.03.

Section 2.04Closing.Upon the terms and subject to the conditions of this Agreement, the sale and
purchase of the Shares shall take place at a closing (the "Closing") to be held at the offices of McDermott, Will & Emery, 7 Bishopsgate, London,
EC2N 3AR, England at 10:00 A.M. London time on the later of (i) November 15, 2002 and (ii) the third Business Day following the satisfaction or waiver of all conditions to
the obligations of the parties set forth in Article VII, or at such other place or at such other time or on such other date as Seller and Purchaser may mutually agree upon in writing (the day
on which the Closing takes place being the "Closing Date").

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Section 2.05Foreign Closings.Except as may be otherwise mutually agreed by the parties, to the extent
that any closing of the sale and purchase of any of the Shares or any of the Related Assets and Liabilities is required to occur at a place outside of the United Kingdom (whether by reason of notarial
deed or otherwise), such a closing (a "Foreign Closing") shall take place, and the executed closing documents shall be held in escrow by the agent
mutually appointed by Seller and Purchaser, on or prior to the Closing (but not prior to the satisfaction of all of the conditions set forth in Article VII relating to such Foreign Closing and
the conditions contained in the Foreign Agreements (as defined below)) at such times and places as may be agreed by Seller and Purchaser. The agent shall hold all such executed documents until such
time as it is advised in a writing signed by Seller and Purchaser that the transactions contemplated hereby have been consummated or terminated. Upon consummation of the transactions contemplated
hereby, the agent shall deliver to each party one fully executed set of the documents that were being held in escrow by the agent. If the transactions contemplated hereby are terminated, the agent
shall deliver to each party the documents executed by such party that were held in escrow by the agent.

In
certain instances the sellers of certain of the Shares and the Related Assets and Liabilities will execute with Purchaser a separate acquisition agreement as may be required with
respect to the Shares and the Related Assets and Liabilities (the "Foreign Agreements"). The Foreign Agreements are intended to serve only as the
operative documents of transfer, and such Foreign Agreements do not alter, modify or amend in any way any of the terms or provisions of this Agreement, including, without limitation, terms and
provisions relating to representations and warranties and indemnification. To the
extent that any conflict exists between any of the terms of any of the Foreign Agreements and this Agreement, the terms of this Agreement shall control.

Section 2.06Closing Deliveries by Seller.At the Closing, Seller shall deliver or cause to be delivered
to Purchaser:



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Section 2.07Closing Deliveries by Purchaser.At the Closing, Purchaser shall deliver to Seller:



Section 2.08Adjustment of Purchase Price.The Purchase Price shall be subject to adjustment after the
Closing as specified in this Section 2.08:



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ARTICLE IIIREPRESENTATIONS AND WARRANTIES OF SELLER

Except
as fairly disclosed in the Disclosure Letter, Seller hereby represents and warrants to Purchaser that:

Section 3.01Incorporation and Authority of Seller.Seller and each Person selling Shares or Related
Assets and Liabilities (collectively, the "Selling Entities") is a corporation duly organized, validly existing under the laws of its jurisdiction of
incorporation. Seller has all necessary corporate power and authority to enter into this Agreement, to carry out its obligations hereunder and to consummate the transactions contemplated hereby. The
execution and delivery by Seller, CUH and CGHG of this Agreement, the performance by Seller of its obligations hereunder, and the consummation by Seller of the transactions contemplated hereby have
been duly authorized by all requisite corporate action on the part of Seller.
This Agreement has been duly executed and delivered by Seller, and (assuming due authorization, execution and delivery by Purchaser) this Agreement constitutes a legal, valid and binding obligation of
Seller, CUH and CGHG, enforceable against Seller, CUH and CGHG in accordance with its terms, subject to general equitable principles and except as enforceability of this Agreement may be limited by
applicable bankruptcy, insolvency, reorganization, moratorium or other similar laws of general application relating to creditor's rights.

Section 3.02Incorporation of the Target Companies.Each Target Company is a corporation duly
incorporated and validly existing under the laws of its jurisdiction of incorporation. Each Target Company is duly qualified and in good standing to do business as a foreign corporation in each
jurisdiction in which the property owned, leased, or operated by it or the nature of its business makes such qualification necessary.

Section 3.03Share Capital of Target Companies; No Subsidiaries.(a) The authorized share capital
or, as the case may be, capital stock of each Target Company and the issued share capital, or, as the case may be, the outstanding shares of capital stock of each Target Company is set forth in
Section 3.03 of the Disclosure Letter.

(b)  There
are no options, warrants, convertible securities or other rights, agreements, arrangements or commitments obligating Seller, any Selling Entity or any Target
Company to issue or sell any shares of capital stock of, or equity interests in any Target Company. The Shares constitute all of the issued and outstanding share capital or outstanding shares of
capital stock of the Target Companies (as applicable) and are owned of record and beneficially solely by Seller and its Affiliates, free and clear of all Encumbrances. All of the Shares have been duly
authorized and validly issued and are fully paid and, where applicable, nonassessable and were not issued in violation of any preemptive

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rights. There are no voting trusts, stockholder agreements, proxies or other agreements or understandings in effect with respect to the voting or transfer of any of the Shares.

(c)  No
Target Company beneficially owns, directly or indirectly, any equity or equity derivative interests in any other Person.

Section 3.04Sufficiency of Assets.Except as set forth in the Disclosure Letter, the assets of the
Target Companies as of the date hereof and the Related Assets and Liabilities constitute all of the assets used in the Grafts Business.

Section 3.05No Conflict.Assuming that all consents, approvals, authorizations and other actions
described in Section 3.06 have been obtained and all filings and notifications described in Section 3.06 have been made, and except as set forth in Section 3.05 of the Disclosure
Letter and except as may result from any facts or circumstances relating solely to Purchaser or an Affiliate thereof, the execution, delivery and
performance of this Agreement by Seller do not and will not, (i) violate or conflict with the Charter and Bylaws of any Selling Entity or any Target Company; (ii) conflict with or
violate any Law or Governmental Order applicable to any Selling Entity or any Target Company; (iii) result in any breach of, or constitute a default (or event which with the giving of notice or
lapse of time, or both, would become a default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, any Material Contract; or (iv) result in the
creation of any Encumbrance on (x) the Shares or (y) the properties or assets of any Target Company or the Related Assets and Liabilities, except in any such case for any violations,
conflicts, breaches, defaults or other matters which would not have a Material Adverse Effect or prevent or materially delay the consummation by Seller of the transactions contemplated hereby.

Section 3.06Consents and Approvals.The execution, delivery and performance of this Agreement by Seller
do not and will not require any consent, approval, authorization or other action by, or filing with or notification to, any Governmental Authority, except (i) the notification requirements of
any applicable antitrust or merger control Laws, (ii) where failure to obtain such consent, approval, authorization or action, or to make such filing or notification, would not prevent or
materially delay the consummation by Seller of the transactions contemplated by this Agreement and would not have a Material Adverse Effect; and (iii) as may be necessary as a result of any
facts or circumstances relating solely to Purchaser or any of its Affiliates.

Section 3.07Financial Information.

(a)  Set
forth in Section 3.07 of the Disclosure Letter is a true and complete copy of the unaudited balance sheet of the Grafts Business as of August 23, 2002
(the "Reference Balance Sheet"). The Reference Balance Sheet was prepared (i) in accordance with the requirements of all relevant Laws and
International Accounting Standards ("IAS"), (ii) from the books and records of the Target Companies and, where relevant, the Selling Entities, and (iii) are not materially misleading.

(b)  The
audited accounts of VAK for the year ending December 31, 2001 and the year ending December 31, 2000 (i) were prepared in accordance with the
requirements of all relevant Laws and UK GAAP on bases consistent with those used in preparing the audited accounts of VAK for the three previous accounting periods, and (ii) show a true and
fair view of the assets and liabilities of VAK as at December 31, 2001 or December 31, 2000 (as applicable).

Section 3.08Absence of Undisclosed Liabilities.There are no liabilities of the Grafts Business of a
nature required to be reflected on a balance sheet prepared in accordance with U.K. GAAP, except (a) liabilities set forth in or otherwise disclosed in the Disclosure Letter;
(b) liabilities reflected or reserved against in the Closing Balance Sheet or referred to in the notes thereto; and (c) liabilities which would not have a Material Adverse Effect.

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Section 3.09Absence of Certain Changes or Events.Since December 31, 2001, the Grafts Business
has been conducted in the ordinary course consistent with past practice and, except as would not reasonably be expected to have a Material Adverse Effect, there has not been: (i) any change in
the condition and repair of the assets of the Grafts Business such that such condition and repair are inconsistent with the uses in which such assets are presently employed, ordinary wear and tear
excepted; (ii) a failure to replenish inventories and supplies of the Grafts Business in the ordinary course of business consistent with past practice; (iii) a purchase commitment by any
Target Company inconsistent with past practice or in excess of the normal, ordinary and usual requirements; (iv) any acquisition (by merger, consolidation or acquisition of stock or assets) by
any Target Company of any Person or other business organization or division thereof for consideration in excess of $500,000 individually or $1,000,000 in the aggregate; or (v) any event or
occurrence which, to the Knowledge of Seller, has had or will have a Material Adverse Effect.

Section 3.10Fair Trading.(a) No agreement, practice or arrangement carried on in connection
with or in relation to the Grafts Business to which the Seller, any of the Target Companies or any of the Related Companies is or has in the 5 years prior to the date of this Agreement been a
party or, (i) is in breach of or would on the expiry or withdrawal of any applicable transitional period provided for under Schedule 13 Competition Act 1998 be in breach of the Chapter I
or the Chapter II prohibition as defined in the Competition Act 1998; (ii) infringes Article 81 of the Treaty establishing the European Community (as amended from time to time (the
"Treaty")) constitutes an abuse of dominant position contrary to Article 82 of the Treaty or infringes any regulation or other enactment made
under Article 83 and/or Article 308 of the Treaty or is or has bean the subject of any enquiry, complaint, investigation or proceeding in respect thereof; (iii) has been notified
to the Director General of Fair Trading (or any "regulator" as that term is defined in s.54 Competition Act 1998) pursuant to the Competition Act 1998 or to the Competition Directorate-General of the
Commission of the European Communities (the "European Commission") and/or to the EFTA Surveillance Authority; (iv) is or has been the subject of
an enquiry, complaint, investigation, proceeding, reference or report under the Fair Trading Act 1973, the Competition Act 1998 or the Competition Act 1980 or has constituted an
anti-competitive practice within the meaning of that Act; (v) is or ought to have been registered in accordance with the provisions of the Restrictive Trade Practices Acts 1976 and
1977 or contravened the provisions of the Resale Prices Act 1976 or is or has been the subject of any enquiry, complaint, investigation or proceeding under any of those Acts; (vi) is by virtue
of its terms or by virtue of any practice for the time being carried on in connection therewith a "Consumer Trade Practice" within the meaning of s.13 Fair Trading Act 1973 and susceptible to or under
reference to the Consumer Protection Advisory Committee or the subject matter of a report to the Secretary of State or the subject matter of an Order by the Secretary of State under the provisions of
Part II of that Act; or (vii) infringes any other competition, restrictive trade practice, anti-trust, fair trading or consumer protection Law applicable in any jurisdiction
in which the Seller has assets employed in the Business or carries on or intends to carry the Business or in which the activities of the Business may have an effect.

(b)  In
relation to the Grafts Business there has not been given any assurance or undertaking (written or oral) to the Restrictive Practices Court, the Director General of
Fair Trading, the Competition Commission, the Secretary of State for Trade and Industry, the European Commission, the EFTA Surveillance Authority or the Courts of the European Communities, or to any
other Authority and is not subject to or in default or contravention of any such assurance or undertaking or any Article, Act, decision, direction, regulation, order or other instrument or undertaking
relating to any matter referred to in this Section 3.10.

(c)  None
of the activities of the Business as currently conducted could give rise to the imposition of any anti-dumping duty or other sanction under any trade
regulation Law in respect of any products manufactured by the Business in recognized market-economy countries or in which the Business trades from such countries.

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(d)  No
anti-dumping duty or other sanction under any trade regulation Law is or has been in force in any area in which the Grafts Business is carried on or
intended to be carried on in respect of products manufactured by the Grafts Business or in which the Grafts Business trades.

(e)  No
undertaking has been given to any Authority under any anti-dumping or other trade regulation Law in relation to the Grafts Business.

(f)    The
Seller is not and has not been in receipt of any aid in relation to the Grafts Business which could be construed as falling within Article 87(1) of the Treaty
other than existing aid as that term is defined in Council Regulation 659/99/EC.

(g)  The
Seller is not and has not been in relation to the Grafts Business the subject of an enquiry, complaint, investigation, proceeding or review in relation to the
receipt or alleged receipt by it of any aid or alleged aid or the misuse by it of any aid received by it and the Seller is not aware of any pending or threatened enquiry, complaint, investigation,
proceeding or review in relation to any such matters.

(h)  The
Seller is not a party to or involved in the award of any contract or any other engagement undertaken or to be undertaken by the Grafts Business of whatever nature
which was awarded or is proposed to be awarded in breach of any Law or administrative practice relating to the procurement of works, goods or services or which has been, is or could reasonably be the
subject of an enquiry, complaint, investigation, proceeding or review in relation to such matters.

(i)    The
Seller is not aware of any pending or threatened enquiry, complaint, investigation, proceeding or review in relation to any matter described in paragraph (f)
above.

Section 3.11Litigation.Except as set forth in Section 3.11 of the Disclosure Letter, there are
no current Actions or, to the Knowledge of Seller, threatened Actions against any Target Company or any Related Company, that are reasonably likely to have a Material Adverse Effect or prevent or
materially delay
the consummation of the transactions contemplated by this Agreement. To the Knowledge of Seller, no Target Company nor any Related Company is subject to any outstanding Governmental Order which,
insofar as can be reasonably foreseen, would have a Material Adverse Effect.

Section 3.12Compliance with Laws; Certain Regulatory Matters.Except as would not reasonably be expected
to have a Material Adverse Effect, the Grafts Business is being conducted in compliance with all Laws and Governmental Orders applicable thereto, and to the Knowledge of Seller, neither any Selling
Entity nor any Target Company nor any Related Company has received any written notice to the effect that the Grafts Business is not in compliance with any applicable Law. Notwithstanding the
foregoing, the representations and warranties in this Section 3.12 do not apply to licenses and permits, environmental matters, intellectual property rights, employee benefit matters and Taxes,
which matters are covered exclusively in Section 3.13, Section 3.14, Section 3.23 and 3.24 and Section 3.18, respectively.

Section 3.13Licenses and Permits.Except as would not reasonably be expected to have a Material Adverse
Effect, each Target Company and each Related Company (i) currently holds all governmental licenses, permits and authorizations necessary for the current use, occupancy and operation of its
business (or the portions thereof that relate to the Grafts Business), and is in compliance with all such permits, licenses and approvals, and (ii) has made all required filings with, or
notifications to, all Medical Product Regulatory Authorities pursuant to applicable requirements of all Laws applicable to the Grafts Business. Notwithstanding the foregoing, the representations and
warranties in this Section 3.13 do not apply to environmental matters, intellectual property rights, employee benefit matters and Taxes, which matters are covered exclusively in
Section 3.14, Section 3.24 and Section 3.25, respectively.

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Section 3.14Environmental Matters.(a) To the Knowledge of Seller, except as would not have a
Material Adverse Effect, no Target Company nor any Related Company: (i) is in violation of any Environmental Law nor has it received notice that any such violation exists; (ii) has
placed, deposited or released any Hazardous Substances upon or under any real property owned or leased by it, except in compliance with Environmental Laws or in such amounts the costs of compliance
with which or results of which would not have a Material Adverse Effect; and (iii) has received notice from any Governmental Authority (other than notices that have been fully complied with or
withdrawn) requiring the removal of any alleged Hazardous Substance, or advising of any pending or contemplated search or investigation of any real property owned or leased by Seller, the costs of
compliance with which or results of which could have a Material Adverse Effect.

(b)  Each
Target Company and each Related Company has been issued, and will maintain until the date of the Closing, all required federal, state and local permits, licenses,
certificates and approvals with respect to its properties relating to, (i) air emissions; (ii) discharges to surface water or groundwater; (iii) noise emissions; (iv) solid
or liquid waste disposal; or (v) the use, generation, storage, transportation or disposal of Hazardous Substances.

Section 3.15Books and Records.Except with respect to Tax matters which are covered in
Section 3.25 and the Tax Deed, all the books and records which are to be delivered or otherwise made available to the Purchaser in accordance with the terms of this Agreement:



Section 3.16Grants.Except for those grants disclosed in Section 3.05 of the Disclosure Letter,
neither Seller, nor the Target Companies nor the Related Companies nor the Selling Entities have applied for or received any grant or other financial assistance from any Authority in relation to the
Grafts Business. Full particulars of all such grants and other financial assistance are given in the Disclosure Letter and there are no circumstances which might lead to the whole or part of any such
grant or other financial assistance becoming repayable or forfeited.

Section 3.17Condition and Use of Fixed Assets.Each of the fixed assets of the Grafts Business is in all
material respects:



Section 3.18Intellectual Property Rights.(a) The Target Companies and the Related Companies are
the sole legal and beneficial owners free from Encumbrances of the Owned Intellectual Property of

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the Grafts Business set out in Section 3.18 of the Disclosure Letter and (where such property is capable of registration) the registered proprietor thereof and own no other Intellectual
Property in relation to the Grafts Business.

(b)  No
third party has been authorized to make any use whatsoever of any Owned Intellectual Property used in the Grafts Business.

(c)  Except
as set forth in the Disclosure Letter all the Intellectual Property used in the Grafts Business is owned by the Target Companies or the Related Companies.

(d)  To
the Knowledge of Seller and except as set forth in the Disclosure Letter, none of the Intellectual Property rights listed in the Disclosure Letter is being used,
claimed, applied for, opposed or attacked by any person.

(e)  To
the Knowledge of Seller, there is no infringement of the Intellectual Property rights listed in the Disclosure Letter or of any rights relating to them by any person.

(f)    There
are no outstanding claims against Seller, the Target Companies or the Related Companies for infringement of any Intellectual Property or of any rights relating to
it used (or which has been used) in the Grafts Business and no such claims have been settled by the giving of any undertakings which remain in force.

(g)  Confidential
information and know-how used in the Grafts Business is kept strictly confidential. To the Knowledge of Seller, no such confidentiality having
been breached. Seller has not disclosed (except in the ordinary course of its business) any of its know-how, trade secrets or lists of customers to any other person. All application and
renewal fees, costs, charges and taxes required for the maintenance or protection of the Intellectual Property rights listed in the Disclosure Letter have been duly paid on time and all other steps so
required have been taken and none of such rights is subject to any existing challenge or attack by a third party or Authority.

(h)  The
Intellectual Property agreements listed in the Disclosure Letter are all the agreements relating to Intellectual Property to which the Target Companies or Related
Companies (in relation only to the Grafts Business) is a party and each of them is valid and binding and Seller is not in material breach of any such agreement.

(i)    All
persons retained or employed in the Grafts Business who in the course of their work in the Grafts Business will or might reasonably be expected to bring into
existence Intellectual Property or things protected by Intellectual Property are, so far as is reasonably practicable, individually bound by agreements with Seller whereby all Intellectual Property
which such persons may bring into existence during their work in the Grafts Business vests in the Target Companies (or Related Companies as applicable) and all such agreements contain terms which, so
far as is reasonably practicable, prevent such persons disclosing any confidential information about the Grafts Business. None of the Intellectual Property used in the Grafts Business is subject to
compulsory licensing or the granting of any licenses of right nor, to the Knowledge of Seller, will it become so by operation of Law.

(j)    The
Grafts Business does not use on its letterhead, brochures, sales literature or vehicles, nor does it otherwise carry on its business under, any name other than the
name(s) set out in the Disclosure Letter.

Section 3.19Material Contracts.(a) Section 3.19 of the Disclosure Letter lists the
following contracts, commitments and agreements with respect to the Grafts Business as of the date of this Agreement (the "Material Contracts"):



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(b)  To
the Knowledge of Seller, the Grafts Business is not, as of the date of this Agreement, in material breach or material violation of, or material default under, any of
the Material Contracts. Each Material Contract is, as of the date of this Agreement, a valid agreement, arrangement or commitment of the Grafts Business enforceable against the applicable constituent
corporation of the Grafts Business in accordance with its terms and, to the Knowledge of Seller, is, as of the date of this Agreement and will
not, as a result of the transactions contemplated hereby, cease to be, a valid agreement, arrangement or commitment of each other party thereto, enforceable in all material respects against each such
party in accordance with its terms, subject to general equitable principles and except as enforceability of any Material Contract may be limited by applicable bankruptcy, insolvency, reorganization,
moratorium or other similar laws of general application relating to creditor's rights.

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Section 3.20Insurances.(a) Set forth in Section 3.20 of the Disclosure Letter is a list
of the insurance policies in which Seller, the Target Companies or the Related Companies has an interest in relation to the Grafts Business (the
"Insurances"), copies of which have been provided to Purchaser as of the date hereof. The Insurances afford to the Grafts Business adequate cover
against fire and such other risks as persons carrying on a similar business as the Grafts Business commonly cover by insurance.

(b)  All
the Insurances are in full force and effect and will be maintained in full force without alterations and there are no premiums in arrears in respect of such
Insurances. There are no known circumstances which might lead to any liability under any of the Insurances being avoided by the insurers or the premiums being materially increased. The Insurances
contain no special or unusual terms, restrictions or rates of premium. There is no claim outstanding under any of the Insurances and Seller is unaware of any circumstances likely to give rise to a
claim or (if Seller were to seek to renew the Insurances) of any circumstances which might cause any of the insurers to refuse to renew them.

Section 3.21Real Property.Set forth in Section 3.21 of the Disclosure Letter is a complete list
of all of the real property owned or leased by the Target Companies. Any real property owned by any Target Company is owned free and clear of Encumbrances other than Permitted Encumbrances. The Target
Companies have a valid leasehold in all real property leased by the Target Companies free and clear of all Encumbrances other than Permitted Encumbrances.

Section 3.22Employees and Workers.(a) As promptly as practicable after the date of this
Agreement, Seller will provide true and complete details of the names, ages and lengths of continuous service of all of the employees of the Grafts Business and by reference to each of them the
remuneration payable, notice period, holiday entitlement and other benefits provided to each employee or any person connected with him or the agency supplying him and (without limiting the generality
of the foregoing) include particulars of all profit sharing, incentive, bonus, commission arrangements and any other benefit to which each employee is entitled or which is regularly provided or made
available to him in any case whether legally binding or not.

(b)  To
the Knowledge of Seller, there are no subsisting contracts for the provision by any person of any consultancy services to the Grafts Business except for those set
forth on Section 3.09 of the Disclosure Letter.

(c)  To
the Knowledge of Seller, none of the Key Employees has given notice terminating his contract of employment or engagement or has been or is to be withdrawn by the
agency supplying him.

(d)  To
the Knowledge of Seller, none of the employees of the Grafts Business is under notice of dismissal.

(e)  To
the Knowledge of Seller, none of the employees of the Grafts Business belongs or has belonged at any material time to an independent trade union recognized by the
Target Companies or Related Companies.

(f)    To
the Knowledge of Seller, there are no employee representatives representing all or any of the employees of the Grafts Business.

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(g)  To the Knowledge of Seller, there is no plan, scheme, commitment, policy, custom or practice (whether legally binding or not) relating to redundancy affecting any of the
employees of the Grafts Business more generous than the statutory redundancy requirements in the relevant jurisdiction.

(h)  To
the Knowledge of Seller, there is no working arrangement, practice, policy or procedure in relation to the Grafts Business which contravenes the Working Time
Regulations 1998 or such other European equivalent of the Working Time Regulations as may be applicable.

(i)    To
the Knowledge of Seller, there is no hourly paid employee employed to work in the Grafts Business who is now paid less than the statutory minimum applicable under the
National Minimum Wage Act 1998.

(j)    All
employees of the Grafts Business performing services in the United States are employed by VAKUS.

(k)  All
share incentive arrangements under which employees of the Grafts Business have received all awards pursuant to their employment by the Grafts Business (the "Share
Schemes") have been disclosed. To the Knowledge of Seller, all Share Schemes have been operated in compliance with their rules and with all applicable Laws and regulations. The UK Sulzer Medica
Approved Savings Related Share Option Plan is a savings related share option scheme approved by the UK Inland Revenue; to the Knowledge of Seller, it has at all times been operated in accordance with
its rules and Seller is not aware of any reason why the UK Inland Revenue would withdraw its approval.

Section 3.23Employee Benefit MattersU.K.Employee benefit plans of the Target Companies
that are subject to the laws of the United Kingdom, (i) are exempt approved schemes within the meaning of Section 592 of the Income and Corporation Taxes Act 1988 and there is no reason
why approval may be withdrawn; and (ii) are contracted out schemes within the meaning of the Pension Schemes Act 1993 and there is in force contracting out certificates covering Seller and VAK,
as applicable, and there is no reason why any such certificates should be cancelled. Every person who has had at any time the right to join, or apply to join, any benefit plan described in the
immediately preceding sentence has been properly advised of that right. No person is excluded from membership of any such plan or from the benefits thereunder in contravention of Article 141 of
the Treaty of Rome, the Pension Act 1995 or other applicable Laws or the requirements or provisions of such plans.

Section 3.24Employee Benefit MattersU.S.(a) Set forth in Section 3.24 of
the Disclosure Letter is a list of each "employee benefit plan" (as defined in Section 3(3) of ERISA) and all other material employee benefit, bonus, incentive, deferred compensation, stock
purchase, stock option, severance, change in control and fringe benefit plans (other than any employment or personnel policy, practice or procedure) maintained, or contributed to, by VAKUS or any of
its Affiliates for current or former employees or directors of VAKUS or for other individuals performing personal services for the Grafts Business in the United States, or with respect to which VAKUS
could incur liability under Section 4069, 4201 or 4212(c) of ERISA (collectively, the "VAKUS Benefit Plans"). With respect to each VAKUS Benefit
Plan, Seller has made available to Purchaser a true and complete copy of the following: (i) the most recent summary plan description for each VAKUS Benefit Plan for which a summary plan
description is required; (ii) such VAKUS Benefit Plan, and each trust agreement relating to such VAKUS Benefit Plan; (iii) the most recent annual report (Form 5500) filed with the
IRS; and (iv) the most recent determination letter issued by the IRS with respect to any VAKUS Benefit Plan qualified under Section 401(a) of the Code.

(b)  To
the Knowledge of Seller, VAKUS Benefit Plans have been operated and administered in compliance in all material respects with the terms of such VAKUS Benefit Plans,
ERISA, the Code and any other applicable Law. With respect to any VAKUS Benefit Plan that is intended to qualify under Section 401(a) of the Code, the plan has received a favorable
determination letter as to its qualification taking into account all "GUST"-required amendments (or such a letter has been applied for within the

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applicable remedial amendment period), and nothing has occurred, whether by action or failure to act, that would cause the loss of such qualification or result in material costs under the Internal
Revenue Service's Employee Plans Compliance Resolution System.

(c)  There
is no agreement, plan or arrangement covering any employee or independent contractor or former employee or independent contractor of VAKUS that, considered
individually or considered collectively with any other such agreement, plan or arrangement, will, or could reasonably be expected to, give rise directly or indirectly to the payment of any amount that
would not be deductible pursuant to Section 280G of the Code or that would be subject to an excise tax under Section 4999 of the Code.

(d)  Except
as set forth in Section 3.24 of the Disclosure Letter, there are no outstanding agreements or arrangements providing for severance payments with respect to
any VAKUS employees.

Section 3.25Taxes.(a) (i) Each Target Company has timely filed or will timely file all
material Tax Returns for any period ending on or before the Closing Date, taking into account any extension of time to file granted thereto; and (ii) except for Taxes for which provision has
been made on the Closing Balance Sheet, all Taxes shown to be payable on such Tax Returns have been or will be paid on a timely basis.

(b)  (i) There
is no claim or assessment pending against any Target Company for any alleged deficiency in Taxes and no Target Company has been notified in writing of
any audit or investigation with respect to any liability of the Grafts Business for Taxes for which it may be liable; and (ii) there are no agreements in effect to extend the period of
limitations for the assessment or collection of any Tax relating to any Target Company.

Section 3.26Solvency.(a) No order has been made, petition presented or resolution passed for
the winding up of any Selling Entity or any of the Target Companies and no meeting has been convened for the purpose of winding up any of them. No Selling Entity has in the last two years been a party
to any transaction which could be avoided in a winding up.

(b)  No
steps have been taken for the appointment of an administrator or receiver (including an administrative receiver) in respect of any Selling Entity or any of the Target
Companies.

(c)  Neither
the Selling Entities, nor any of the Target Companies has made or proposed any arrangement or composition with its creditors or any class of its creditors;

(d)  Neither
the Selling Entities, nor any of the Target Companies is insolvent, or unable to pay its debts within the meaning of the applicable insolvency legislation and
has not stopped paying its debts as they fall due.

(e)  No
distress, execution or other process has been levied against any Selling Entity, or any of the Target Companies. No unsatisfied judgment is outstanding against any
Selling Entity or any of the Targeted Companies.

(f)    No
floating charge created by any Selling Entity or any of the Target Companies has crystallized.

(g)  No
event analogous to any of the foregoing has occurred in or outside the United Kingdom.

Section 3.27Brokers.Except for Lehman Brothers
("Lehman"), no broker, finder or investment banker is entitled to any brokerage, finder's or other fee or commission in connection with the transactions
contemplated by this Agreement based upon arrangements made by or on behalf of Seller or any Target Company. Seller is solely responsible for the fees and expenses of Lehman.

Section 3.28No Implied Representations and Warranties.No Selling Entity nor any
Target Company is making any representation or warranty whatsoever, express or implied, except those representations and warranties of Seller explicitly set forth in this Agreement or any certificate

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contemplated hereby and delivered to Purchaser in connection herewith. Subject to the foregoing, the Shares, the assets and business of the Target Companies and the Related Assets and Liabilities
being acquired by Purchaser at the Closing as a result of this Agreement and the transactions contemplated hereby shall be acquired by Purchaser on an "as is, where is" basis and in their present
condition, and Purchaser shall rely solely upon its own examination thereof. In any event, except as explicitly set forth herein none of the Selling Entities, the Target Companies nor any of their
respective officers, directors, stockholders, employees, Affiliates or representatives, as the case may be, has made or is making any representation, express or implied, as to the value of any asset
or business being so acquired, or any warranty of merchantability, suitability or fitness for a particular purpose or quality, or as to the condition or workmanship thereof, or as to the absence of
any defects therein, whether latent or patent.

Section 3.29JLL Contract.The copy of the JLL Contract attached to the Disclosure Letter is a true and
complete copy of the JLL Contract and there are no written amendments or variations and to the Knowledge of Seller, oral amendments or variations, to the JLL Contract or other written agreements or
arrangements and, to the Knowledge of Seller, oral agreements or arrangements, between Seller and VAK.

Section 3.30Inventory.(a) All finished goods included in the inventory are in good condition,
meet in all material respects all relevant statutory, regulatory and industry-accepted standards and contractual specifications and are capable of being sold in the ordinary course of the Grafts
Business in accordance with their current price list without discount, rebate or allowance to a purchaser. No material part of the inventory is obsolete, redundant (being out of fashion or demand) or
slow moving.

(b)  The
levels of raw materials, partly and fully finished goods, packaging and promotional material are included in the transactions contemplated by this Agreement are
sufficient for the normal requirements of the Grafts Business and are adequate (but not excessive) in relation to the current and anticipated trading requirements of the Grafts Business as a whole.

Section 3.31Product Liability.(a) There is no current or pending claim in respect of Product
Liability, to the Knowledge of Seller, threatened in writing against or expected by Seller or any of its Affiliates in relation to the Grafts Business and to the Knowledge of Seller there are no
circumstances which are likely to give rise to any such claim. For this purpose, "Product Liability" means a liability arising out of death, personal
injury or damage to property caused by a defective product or defective services sold, supplied or provided in the course of the Grafts Business on or prior to the date of this Agreement.

(b)  Within
the four years prior to the Closing Date, there has not been either (i) implanted, or (ii) sold any product or service which, to the Knowledge of
Seller (x) is, was, or will become, in any material
respect faulty or defective; or (y) does not comply in any material respect with any warranty or representation expressly or impliedly made by or on behalf of Seller in respect of it or with
all applicable Laws, standards and requirements in respect thereof,provided, however, that in the case of such sold products referred to in
(ii) above, this warranty is only given in respect of those sold products that have been implanted within the period ending 90 days after the Closing Date.

(c)  To
the Knowledge of Seller, there has not been received a prohibition notice, a notice to warn or a suspension notice under the Consumer Protection Act 1987 in relation
to any product or service of the Grafts Business.

Section 3.32Notice of Developments.To the Knowledge of Seller, Seller has not received a notice in
writing with respect to any Material Contracts or any material ongoing supply or distribution relationship of an intention to terminate or not renew any such contract or terminate such supply or
distribution relationship.

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Section 3.33Computer Systems.(i) Except as has not had a Material Adverse Effect, the hardware
and software of the Grafts Business have not in the past three years unduly interrupted or hindered the running or operation of the Grafts Business, and except as would not be reasonably expected to
have a Material Adverse Effect, have no defects in operation which so affect the Grafts Business; and (ii) the computer systems have reasonably adequate capability and capacity for all of the
processing and functions required by the Grafts Business as of the Closing Date.

ARTICLE IVREPRESENTATIONS AND WARRANTIES OF PURCHASER

Purchaser
hereby represents and warrants to Seller that:

Section 4.01Incorporation and Authority of Purchaser.Purchaser is a corporation duly incorporated,
validly existing and in good standing under the laws of its jurisdiction of incorporation and has all necessary corporate power and authority to enter into this Agreement, to carry out its obligations
hereunder and to consummate the transactions contemplated hereby. The execution and delivery by Purchaser of this Agreement, the performance by Purchaser of its obligations hereunder and the
consummation by Purchaser of the transactions contemplated hereby have been duly authorized by all requisite corporate action on the part of Purchaser. This Agreement has been duly executed and
delivered by Purchaser, and (assuming due authorization, execution and delivery by Seller, CUH and CGHG) this Agreement
constitutes a legal, valid and binding obligation of Purchaser, enforceable against Purchaser in accordance with its terms, subject to general equitable principles and except as enforceability of this
Agreement may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or other similar laws of general application relating to creditor's rights.

Section 4.02No Conflict.Assuming that all consents, approvals, authorizations and other actions
described in Section 4.03 have been obtained and all filings and notifications described in Section 4.03 have been made, and except as may result from any facts or circumstances relating
solely to the Selling Entities or the Target Companies, the execution, delivery and performance by Purchaser of this Agreement do not and will not, (i) violate or conflict with the Charter or
Bylaws of Purchaser; (ii) conflict with or violate any Law or Governmental Order applicable to Purchaser or; (iii) result in any breach of, or constitute a default (or event which with
the giving of notice or lapse of time, or both, would become a default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, any note, bond, mortgage,
indenture, contract, agreement, lease, license, permit, franchise or other instrument to which Purchaser or any of its subsidiaries is a party or by which any of their assets or properties is bound,
except in any such case for any violations, conflicts, breaches, defaults or other matters that would not prevent or materially delay the consummation by Purchaser of the transactions contemplated
hereby.

Section 4.03Consents and Approvals.The execution, delivery and performance by Purchaser of this
Agreement do not and will not require any consent, approval, authorization or other action by, or filing with or notification to, any Governmental Authority except, (i) the notification
requirements any applicable antitrust or merger control Laws; (ii) where failure to obtain such consent, approval, authorization or action, or to make such filing or notification; would not
prevent or materially delay the consummation by Purchaser of the transactions contemplated by this Agreement; and (iii) as may be necessary as a result of any facts or circumstances relating
solely to the Selling Entities or the Target Companies.

Section 4.04Litigation.There are no current Actions pending or, to the knowledge of Purchaser, Actions
threatened against Purchaser that are reasonably likely to prevent or materially delay the consummation by Purchaser of the transactions contemplated by this Agreement.

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Section 4.05Investment Purpose.Purchaser is acquiring the Shares solely for the purpose of investment
and not with a view to, or for offer or sale in connection with, any distribution thereof.

Section 4.06Financing.Purchaser has adequate funds available to pay the Base Purchase Price.

Section 4.07Brokers.Except for Nomura International plc
("Nomura"), no broker, finder or investment banker is entitled to any brokerage, finder's or other fee or commission in connection with the transactions
contemplated by this Agreement based upon arrangements made by or on behalf of Purchaser. Purchaser is solely responsible for the fees and expenses of Nomura.

ARTICLE VADDITIONAL AGREEMENTS

Section 5.01Conduct of Business Prior to the Closing.Seller covenants and agrees that, between the date
of this Agreement and the Closing Date, except as set forth in Section 5.01 of the Disclosure Letter or as contemplated by any other provision of this Agreement, unless Purchaser shall
otherwise agree in writing:



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Section 5.02Investigation; Confidentiality.(a) Purchaser acknowledges and agrees that it,
(i) has made its own inquiry and investigation into, and based thereon has formed an independent judgment concerning the Grafts Business; (ii) has been furnished with or given adequate
access to such information about the Grafts Business as it has requested; (iii) has had independent legal, financial and technical advice relating to the Grafts Business and the terms of this
Agreement and the documents to be executed pursuant hereto; and (iv) will not assert any claim against Seller or any of its Affiliates or any of Seller's or its Affiliates' respective
directors, officers, employees, agents, stockholders, consultants, investment bankers, accountants, counsel or representatives, or hold Seller or any such persons liable, for any inaccuracies,
misstatements or omissions with respect to information (other than the representations and warranties of Seller contained in this Agreement) furnished by Seller or such persons concerning Seller or
the Grafts Business. Any implied warranty or similar rights applicable to any of the transactions contemplated hereby under the Law of any jurisdiction is hereby expressly and irrevocably waived by
Purchaser to the fullest extent permitted by such Law, and Purchaser agrees that it shall not seek to enforce any such implied warranties or similar rights.

(b)  In
connection with Purchaser's investigation of the Grafts Business, Purchaser has received certain estimates, projections and other forecasts, and certain plan and
budget information. Purchaser

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acknowledges that there are uncertainties inherent in attempting to make such estimates, projections, forecasts, plans and budgets, that Purchaser is familiar with such uncertainties, that Purchaser
is taking full responsibility for making its own evaluation of the adequacy and accuracy of all estimates,
projections, forecasts, plans and budgets so furnished to it, and that Purchaser will not assert any claim against Seller or any of its Affiliates or any of Seller's or its Affiliates' respective
directors, officers, employees, agents, stockholders, consultants, investment bankers, accountants, counsel or representatives, or hold Seller or any such persons liable with respect thereto.
Accordingly, Seller makes no representation or warranty with respect to any estimates, projections, forecasts, plans or budgets referred to in this Section 5.02.

(c)  The
terms of the letter agreement dated as of June 25, 2002 (the "Confidentiality Agreement") between Lehman, as
agent for Seller, and Purchaser are incorporated by reference herein and shall continue in full force and effect until the Closing, at which time the Confidentiality Agreement and the obligations of
Purchaser under this Section 5.02(c) shall terminate;provided, however, that the Confidentiality Agreement shall not terminate with respect to
that portion of the Evaluation Material (as defined in the Confidentiality Agreement) that is not exclusively related to the transactions contemplated by this Agreement. If this Agreement, is, for any
reason, terminated prior to the Closing Date, the Confidentiality Agreement shall continue in full force and effect thereafter in accordance with its terms. Potential insurers of Purchaser shall be
deemed to be "Representatives" for purposes of the Confidentiality Agreement.

(d)  Following
the Closing, Seller agrees to, and will cause its agents, representatives, Affiliates, employees, officers and directors to, (i) treat and hold as
confidential (and not disclose or provide access to any Person), in a manner consistent with its practices prior to the date hereof, all information concerning the Grafts Business that was previously
treated by Seller and its Affiliates as confidential; (ii) in the event that Seller or any such agent, representative, Affiliate, employee, officer or director becomes compelled by Law
(including any requirement of the New York Stock Exchange or the Swiss Exchange) to disclose any such information, provide Purchaser with prompt written notice of such requirement so that Purchaser
may seek a protective order or other remedy or waive compliance with this Section 5.02(d); and (iii) in the event that such protective order or other remedy is not obtained or is not
available, or Purchaser waives compliance with this Section 5.02(d), furnish only that portion of such confidential information that is legally required to be provided and use all reasonable
efforts to obtain assurances that confidential treatment will be accorded such information;provided, however, that this sentence shall not apply to any
information that, at the time of disclosure, is available publicly and was not disclosed in breach of this Section 5.02(d) by Seller, its agents, representatives, Affiliates, employees,
officers or directors. Anything in this Section 5.02(d) to the contrary notwithstanding, Seller and its agents, representatives, Affiliates, employees, officers and directors shall have the
right to use and disclose confidential information described in this Section 5.02(d) to the extent such confidential information is necessary for the conduct of the business of Seller and its
Affiliates.

Section 5.03Access to Information.(a) From the date hereof until the Closing Date, upon
reasonable notice, Seller shall, and shall cause the Target Companies and each of their respective officers, directors, employees, auditors and agents to, (i) afford the officers, employees and
authorized agents and representatives of Purchaser reasonable access, during normal business hours, to the offices, properties, books and records of the Target Companies and the Related Assets and
Liabilities; and (ii) furnish to the officers, employees and authorized agents and representatives of Purchaser such additional financial and operating data and other information regarding the
Target Companies and the Related Assets and Liabilities as Purchaser may from time to time reasonably request;provided, however,that such
investigation shall not unreasonably interfere with any of the businesses or operations of Seller or any of its Affiliates.

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(b)  In order to facilitate the resolution of any claims made by or against or incurred by Seller or any Affiliate or for which Seller or any of its Affiliates remains
liable, after the Closing Date and in order to exchange information pursuant to Section 5.03, upon reasonable notice, Purchaser shall (i) afford the officers, employees and authorized
agents and representatives of Seller reasonable access, during normal business hours, to the offices, properties, books and records of Purchaser concerning the Target Companies; (ii) furnish to
the officers, employees and authorized agents and representatives of Seller such additional financial and other information regarding the Target Companies as Seller or such officers, employees and
authorized agents and representatives may from time to time reasonably request; and (iii) make available to Seller the employees of Purchaser in respect of the Target Companies whose
assistance, testimony or presence is necessary to assist Seller in evaluating any such claims and in defending such claims, including the presence of such persons as witnesses in hearings or trials
for such purposes;provided, however, that such investigation shall not unreasonably interfere with the business or operations of Purchaser or any of
its Affiliates.

(c)  Notwithstanding
the foregoing, Seller shall not be required, prior to the Closing Date, to disclose, or cause the disclosure of, to the officers, employees or authorized
agents or representatives of Purchaser (or provide access to any offices, properties, books or records of Seller or any of its Affiliates that could result in the disclosure to such persons or others
of) any confidential information relating to pricing and marketing plans, to the extent that Seller reasonably believes that disclosure of such information would create a significant risk of a
violation of any antitrust or competition Law, nor shall Seller be required to permit or cause others to permit the officers, employees or authorized agents or representatives of Purchaser to copy or
remove from the offices or properties of Seller or any of its Affiliates any documents, drawings or other materials that might reveal any such confidential information.

Section 5.04Books and Records.(a) Except as otherwise provided in Article VII, Purchaser
agrees that it shall preserve and keep all books and records in relation to the period prior to the Closing Date in respect of the Target Companies in Purchaser's possession for a period of at least
six years from the Closing Date. After such six-year period, before Purchaser shall dispose of any of such books and records, at least 90 calendar days' prior written notice to such effect
shall be given by Purchaser to Seller, and Seller shall be given an opportunity during such 90-day period, at its cost and expense, to remove and retain all or any part of such books and
records as Seller may select. During such six-year period, duly authorized representatives of Seller shall, upon reasonable notice, have access thereto during normal business hours to
examine, inspect and copy such books and records.

(b)  If,
in order properly to prepare documents required to be filed with Governmental Authorities or its financial statements or required under any applicable Law, it is
necessary that either party hereto (or any of their respective Affiliates) or any successors be furnished with additional information relating to
the Target Companies and such information is in the possession of the other party hereto or any of its Affiliates, such party agrees to use its best efforts to furnish such information to such other
party as soon as reasonably practicable, at the cost and expense of the party being furnished such information.

Section 5.05Satisfaction of Conditions Precedent; Regulatory and Other Authorizations; Notices and
Consents.(a) Seller and Purchaser shall use all reasonable efforts to cause the satisfaction of the conditions precedent contained in Article VII.
Each party hereto shall use all reasonable efforts to obtain all authorizations, consents, orders and approvals of all Governmental Authorities that may be or become necessary for its and its
Affiliates' execution and delivery of, and the performance of their obligations pursuant to, this Agreement and shall cooperate fully with the other party in promptly seeking to obtain all such
authorizations, consents, orders and approvals. Each party hereto agrees to make any appropriate filing pursuant to relevant anti-trust, anti-competition and merger control
Laws with respect to the transactions contemplated hereby as promptly as practicable, and in any event within ten Business Days of the date hereof, and to supply promptly any additional information
and documentary material that may be requested pursuant to such Laws. The parties hereto acknowledge

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that time shall be of the essence in this Agreement and agree not to take any action or omit to take any action that will have the effect of unreasonably delaying, impairing or impeding the receipt
of any required authorizations, consents, orders or approvals.

(b)  Without
limiting the generality of Purchaser's undertakings pursuant to Section 5.05(a), Purchaser shall:



(c)  Seller
shall give promptly such notices to third parties and use reasonable efforts to obtain such third party consents (not including the consents of any Governmental
Authorities) as may be necessary in connection with the transactions contemplated by this Agreement; provided that Seller and its Affiliates shall not be required to make any payment to any such
Person to induce such Person to grant such consent or waiver.

Section 5.06Notification to Governmental Authorities.Purchaser shall, as promptly as practicable after
the Closing, and in any event not later than the earlier of (i) 60 calendar days after the Closing Date and (ii) the expiration date of the applicable notification period, notify each
Governmental Authority which requires such notification and (x) which is responsible for the regulatory supervision and administration of each of the Target Companies or (y) which
otherwise requires notification of the transactions contemplated by this Agreement.

Section 5.07Non-Competition.In consideration of the covenants given by Purchaser herein,
Centerpulse AG agrees that, for a period of two years after the Closing Date (the "Non-Competition Period"), neither Centerpulse AG nor any
Person controlled by Centerpulse AG will: (a) own, control or operate an entity that is in the business of developing, manufacturing, distributing or selling vascular grafts (the
"Competitive Business");provided, however, that the foregoing shall not prohibit Seller or any

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Person controlled by Seller from (i) acquiring, directly or indirectly, securities of any Person traded in a public market that participates in a Competitive Business; provided that Seller and
its Affiliates do not, in the aggregate, own more than 5% of any class of securities of such Person; or (ii) acquiring a company (the "Diversified
Company") or a business (x) having not more than 25% of its gross revenues attributable to a Competitive Business, or (y) having more than 25% of its gross
revenues attributable to a Competitive Business, so long as, with respect to such Diversified Company or business acquired that shall have derived more than 25% of its gross revenues from a
Competitive Business, Seller shall have divested itself within 12 months of its acquisition of such Diversified Company of the assets of such Diversified Company that constitute the Competitive
Business; or (b) either on its own account or in conjunction with or on behalf of any other person, in connection with any Competitive Business, endeavor to entice away from any of the Target
Companies or Related Companies any person who as at the date of this Agreement is (or within the one year period prior to the date of this Agreement has been) a client or customer of the Grafts
Business; or (c) either on its own account or in conjunction with or on behalf of any other person, in connection with any Competitive Business solicit or endeavor to entice away any person who
at the date of this Agreement is an officer, manager, senior employee
agent or consultant of any of the Target Companies or Related Companies;provided, however, that in the case of the Related Companies this restriction
shall only apply in relation to those officers, managers, senior employees, agents or consultants engaged in the Grafts Business.

Section 5.08Intercompany Arrangements.Prior to the Closing Date, Seller shall cause any contract or
arrangement that is disclosed (or should have been disclosed) in Section 3.19(a)(vi) of the Disclosure Letter, other than those contracts or arrangements set forth in Section 5.08
of the Disclosure Letter, to be terminated or otherwise amended to exclude any Target Company as a party thereto.

Section 5.09Insurance Coverage.Effective 12:01 a.m. on the Closing Date, each Target Company and
the property and assets thereof shall cease to be insured by any Selling Entity's (other than such Target Company's) insurance policies, and Purchaser shall have no rights with respect to any such
policy.

Section 5.10Transition Services.Following the Closing Date, Seller shall provide, or cause to be
provided, to Purchaser, and Purchaser shall provide, or cause to be provided, to Seller and its Affiliates, certain services which are currently provided by Seller and its Affiliates to the Target
Companies or by the Target Companies to the other businesses of Seller and its Affiliates, all as more fully set forth in a transition services agreement in a form to be agreed to between Seller and
Purchaser (the "Seller Transition Services Agreement") and in a transition services agreement in a form to be agreed to between Seller and Purchaser
(the "Purchaser Transition Services Agreement"), respectively, each to be entered into by Seller and Purchaser as of the Closing Date, and which cover,
among other things, the items specified on Schedule 5.10 of the Disclosure Letter.

Section 5.11Continued Grafts Employees.Seller shall use reasonable efforts to comply with the advice of
counsel in connection with notification and consultation with Continued Grafts Employees.

Section 5.12Further Action.Each of the parties hereto shall execute and deliver such documents and
other papers and take such further action as may be reasonably required to carry out the provisions hereof and to make effective the transactions contemplated hereby.

Section 5.13German Newco.CGHG shall procure the incorporation of CVD (which shall be a direct or
indirect subsidiary of CGHG) and shall procure the acquisition by CVD of the Grafts Business of Sulzer Cardiovascular GmbH prior to, or simultaneously with, Closing.

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ARTICLE VIEMPLOYEE MATTERS

Section 6.01Continuation of BenefitsTarget Companies.For a period of two years after the
Closing Date (or such longer period as may be required by Law), Purchaser shall provide, or cause each Target Company to provide, each current employee and former employee of such Target Company with
benefits (including, without limitation, retirement and welfare benefits) that are no less favorable than the benefits provided under the applicable employee benefit plans applicable to such employee
as in effect at the Closing Date. To the extent that service is relevant for vesting or benefit calculations or allowances (including, without limitation, entitlements to vacation and sick days) under
any plan or arrangement maintained in order to provide the benefits described in the previous sentence, such plan or arrangement shall credit such Target Company's employees for service at or prior to
the Closing Date. Without limiting the foregoing, Purchaser shall also provide, or shall cause each Target Company to provide, each employee of such Target Company (and their eligible dependants) with
coverage as of the Closing Date under Purchaser's group medical plan with immediate eligibility and no pre-existing condition limitations.

Section 6.02Employment of Continued Grafts Employees.(a) Seller shall take action to procure
the transfer of the Continued Grafts Employees effective as of the Closing Date. Purchaser or its wholly-owned subsidiary shall assume or retain and be responsible for the employment (including any
employment contracts) of the Continued Grafts Employees and Purchaser shall take any and all actions necessary or appropriate (if any) to continue the employment of such Continued Grafts Employees and
Purchaser shall assume or retain all obligations and liabilities relating to their employment under local laws and practices without Seller or any of its Affiliates having any liability to any such
employees for severance, redundancy, termination, payment in lieu of notice, indemnity or other payments to any of such employees by reason of or as a result of the actions contemplated by this
Agreement.

(b)  Effective
as of the Closing Date, Purchaser shall establish and qualify or register with applicable regulatory authorities employee benefit plans for, or shall extend
existing Purchaser employee benefit plans, programs, policies and arrangements to, the Continued Grafts Employees which are in accordance with local Law and which provide benefits, for not less then
two years following the Closing Date, to the Continued Grafts Employees which are substantially similar in the aggregate to those provided to the Continued Grafts Employees immediately prior to the
Closing Date.

Section 6.03Cash Compensation.For a period of one year following the Closing Date, Purchaser shall
ensure that each employee of the Target Companies and each Continued Grafts Employee shall continue to be paid base salary at no lower a rate than that in effect on the Closing Date with respect to
such employee.

Section 6.04Severance.For a period of one year following the Closing Date, Purchaser shall, or shall
cause the Target Companies to, maintain severance policies, programs and arrangements that are substantially identical to, and no less favorable than, the severance policies, programs and arrangements
applicable to employees of the Target Companies and the Continued Grafts Employees as of the Closing Date.

Section 6.05Pension Schemes.Certain matters in relation to the pension schemes shall be handled as
specified in the Pension Schedule.

Section 6.06401(k) Plan.Effective as of the Closing Date, all persons employed by VAKUS as of such date
who are participants ("401(k) Plan Participants") in the Sulzer Medica USA Inc. Retirement Plan (the "Seller 401(k)
Plan") shall no longer accrue benefits under the Seller 401(k) Plan and Seller shall take all actions necessary to achieve this result. As of the Closing Date, Seller shall
cause each such 401(k) Plan Participant to be fully vested in such person's account balance in the Seller 401(k) Plan. As soon as practicable following the Closing Date, Seller shall cause the Seller
401(k) Plan

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to make available to each 401(k) Plan Participant a distribution of his or her account balance under such plan. On or as soon as practicable following the Closing Date (but no later than
60 days thereafter), Purchaser shall establish or make available to the 401(k) Plan Participants a savings plan intended to be qualified under Sections 401(a) and 401(k) of the Code (the
"Purchaser Plan"), which shall (i) take into account service performed for the Target Company prior to the Closing Date for purposes of
eligibility and vesting under such plan, and (ii) accept rollover contributions of lump sum distributions made from the Seller 401(k) Plan for those 401(k) Plan Participants who elect to make
such rollover contributions. Such rollover contributions may include outstanding loans from the Seller 401(k) Plan to the 401(k) Plan Participants.

Section 6.07Purchaser Plans.Except as otherwise specifically provided for herein or in the Pensions
Schedule, effective as of the Closing Date, current and former employees of the Target Companies and Continued Grafts Employees who, as of the Closing Date are not employed by Seller or its
Affiliates, shall cease to be active participants in any employee benefit plans maintained by Seller and its Affiliates.

Section 6.08Retention Bonuses.Seller agrees that those retention bonus payments payable to the
individuals listed on Section 6.08 of the Disclosure Letter pursuant to retention bonus agreement relating to the transaction contemplated by this Agreement are for the account of Seller and
Seller agrees to indemnify and hold harmless Purchaser (or its Affiliates, as the case may be) in respect of any liability to the employees listed on Section 6.08 of the Disclosure Letter in
respect of those retention bonus payments. The parties agree to do all such things as may be required to give effect to the provisions of this clause.

ARTICLE VIICONDITIONS TO CLOSING

Section 7.01Conditions to Obligations of Seller.The obligations of Seller to consummate the
transactions contemplated by this Agreement shall be subject to the fulfillment or waiver, at or prior to the Closing, of each of the following conditions:



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Section 7.02Conditions to Obligations of Purchaser.The obligations of Purchaser to consummate the
transactions contemplated by this Agreement shall be subject to the fulfillment or waiver, at or prior to the Closing, of each of the following conditions:



ARTICLE VIIIINDEMNIFICATION

Section 8.01Survival of Representations and Warranties.Subject to the limitations and other provisions
of this Agreement, the representations and warranties of the Seller set forth in Article III and the representations and warranties of Purchaser set forth in Article IV herein shall
survive the Closing and shall remain in full force and effect until March 31, 2004.

Section 8.02Indemnification by Purchaser.(a) Purchaser agrees, subject to the other terms and
conditions of this Agreement, to indemnify Seller and its Affiliates, officers, directors, employees, agents, successors and assigns (each a "Seller Indemnified
Party") against and hold them harmless from all liabilities, losses, damages, claims, costs and expenses (including reasonable attorney's fees) (collectively,
"Losses") actually incurred by them arising out of, (i) the breach of any of the Purchaser Warranties herein; (ii) the breach of any
covenant or agreement of Purchaser herein (other than the

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Tax Deed and Pension Schedule (other than Section 9(C) "Sex equality")), it being understood that the sole remedy for breach thereof shall be pursuant to the Tax Deed or Pension Schedule
(other than Section 9(C) "Sex equality"), as the case may be); and (iii) the conduct of the business of the Grafts Business following the Closing. Notwithstanding anything in
Article VIII to the contrary, no claim may be asserted nor may any action be commenced against Purchaser pursuant to Section 8.02(a)(i), unless written notice of such claim or action is
received by Purchaser describing in reasonable detail the facts and circumstances with respect to the subject matter of such claim or action on or prior to the date on which the representation or
warranty on which such claim or action is based ceases to survive as set forth in Section 8.01.

(b)  Notwithstanding
anything in this Agreement to the contrary, no claim may be made against Purchaser for indemnification pursuant to Section 8.02(a)(i) with
respect to any individual item of Loss or items of Losses arising out of substantially similar facts and circumstances, unless such item or items of Losses exceed $100,000 (the
"Designated Amount") and no claim may be made against Purchaser pursuant to Section 8.02(a)(i) unless the aggregate of all such Losses of
the Seller Indemnified Parties referred to in Section 8.02(a)(i) shall exceed $1,000,000 (the "Purchaser's Threshold Amount"), after which
all indemnifiable Losses shall be payable, and not only the amount in excess of the Purchaser's Threshold Amount. Notwithstanding anything in this Agreement to the contrary, no Seller Indemnified
Party shall be indemnified pursuant to Section 8.02(a)(i) if, and to the extent that, the aggregate of all Losses of the Seller Indemnified Parties for which the Purchaser Indemnified
Parties previously shall have received indemnification pursuant to Section 8.02(a)(i) shall have exceeded 10% of the Base Purchase Price.

(c)  Payments
by Purchaser pursuant to Section 8.02(a) shall be limited to the amount of any Loss that remains after deducting therefrom any Tax benefit to the Seller
Indemnified Parties and any insurance proceeds and any indemnity, contribution or other similar payment recoverable by the Seller Indemnified Parties from any third party with respect thereto. A Tax
benefit will be considered to be recognized by the Seller Indemnified Parties for purposes of this Section 8.02 in the Tax period in which the indemnity payment occurs, and the amount of the
Tax benefit shall be determined by assuming that the Seller Indemnified Party is in the maximum applicable statutory Tax bracket after any deduction or other allowances reportable with respect to a
payment hereunder.

(d)  Any
Seller Indemnified Party shall give Purchaser prompt written notice of any claim, assertion, event or proceeding by or in respect of a third party of which such
Seller Indemnified Party has knowledge concerning any Loss as to which such Seller Indemnified Party may request indemnification hereunder;provided,
however, that the failure to give such notice shall not relieve Purchaser from any Liability or obligation pursuant to this Section 8.02 unless and only to the extent
Purchaser is materially prejudiced thereby. Purchaser shall have the right to assume, through counsel reasonably acceptable to Seller, the defense or settlement of any such claim or proceeding at its
own expense. If Purchaser elects to assume the defense of any such claim or proceeding, the Seller Indemnified Party may participate in such defense, but in such case the expenses of the Seller
Indemnified Party shall be paid by such Seller Indemnified Party, the Seller Indemnified Party shall provide Purchaser with reasonable access to its records and personnel relating to any such claim,
assertion, event or proceeding during normal business hours and shall otherwise cooperate with Purchaser in the defense or settlement thereof, and Purchaser shall reimburse such Seller Indemnified
Party for all the reasonable out-of-pocket expenses of such Seller Indemnified Party in connection therewith;provided, however,
that neither Seller nor Purchaser shall be required pursuant to this Section 8.02 to disclose any privileged information or any attorney work product. If Purchaser elects to assume the defense
of any such claim or proceeding, the Seller Indemnified Party shall not pay, or permit to be paid, any part of any claim or demand arising from such asserted liability, unless Purchaser consents in
writing to such payment or unless Purchaser, subject to the last sentence of this Section 8.02(d), withdraws from the defense of such asserted liability, or unless a final judgment from which
no appeal may be taken by or on behalf of Purchaser is entered against the Seller Indemnified

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Party for such liability. If Purchaser shall fail to undertake any such defense, the Seller Indemnified Party shall have the right to undertake the defense or settlement thereof, at Purchaser's
expense. If the Seller Indemnified Party assumes the defense of any such claim or proceeding pursuant to this Section 8.02(d) and proposes to settle such claim or proceeding prior to a final
judgment thereon or to forgo appeal with respect thereto, then the Seller Indemnified Party shall give Purchaser prompt written notice thereof and Purchaser shall have the right to participate in the
settlement or assume or reassume the defense of such claim or proceeding.

(e)  Seller
hereby acknowledges and agrees that (except in the case of fraud, in which Seller reserves any and all rights and remedies available to it) its sole and exclusive
remedy with respect to any and all claims relating to the subject matter of this Agreement and the transactions contemplated hereby shall be pursuant to the indemnification provisions set forth in the
Tax Deed and in this Article VIII and specific performance as contemplated by Section 10.15. In furtherance of the foregoing, Seller hereby waives, to the fullest extent permitted under
applicable Law, any and all rights, claims and causes of action it may have against Purchaser or any of its Affiliates arising under or based upon any Law (including, without limitation, any such
rights, claims or causes of action arising under or based upon common law or otherwise) with respect to any and all claims relating to the subject matter of this
Agreement and the transactions contemplated hereby except as set forth in the preceding sentence (except in the case of fraud, in which case Seller reserves any and all rights and remedies available
to it).

(f)    Except
as expressly set forth in this Agreement, Purchaser is not making any representation, warranty, covenant or agreement with respect to the matters contained
herein. Anything herein to the contrary notwithstanding, no breach of any representation, warranty, covenant or agreement contained herein shall give rise to any right on the part of Seller, after the
consummation of the purchase and sale of the Shares as contemplated by this Agreement, to rescind this Agreement or any of the transactions contemplated hereby.

(g)  Notwithstanding
anything to the contrary contained herein, Purchaser shall not be liable to or otherwise responsible to any other Person for consequential, incidental or
punitive damages or for diminution in value or lost profits that arise out of or related to this Agreement or the performance or breach thereof.

Section 8.03Indemnification by Seller.(a) Seller agrees, subject to the other terms and
conditions of this Agreement, to indemnify Purchaser and its Affiliates, officers, directors, employees, agents, successors and assigns (each a "Purchaser Indemnified
Party") against and hold them harmless from all Losses actually incurred by them arising out of (i) the breach of any representation or warranty of Seller herein and
(ii) the breach of any covenant or agreement of Seller herein (other than Section 3.25, the Tax Deed and Pension Schedule (other than Section 9(C) "Sex equality")), it being
understood that the sole remedy for breach of such representations, warranties, covenants and agreements shall be pursuant to the Tax Deed or Pension Schedule (other than Section 9(C) "Sex
equality"), as the case may be). Notwithstanding anything in this Article VIII to the contrary, no claim may be asserted nor may any action be commenced against Seller pursuant to
Section 8.03(a)(i) unless written notice of such claim or action is received by Seller describing in reasonable detail the facts and circumstances with respect to the subject matter of
such claim or action on or prior to the date on which the representation or warranty on which such claim or action is based ceases to survive as set forth in Section 8.01.

(b)  Notwithstanding
anything in this Agreement to the contrary, no claim may be made against Seller for indemnification pursuant to Section 8.03(a)(i) with
respect to any individual item of Loss or items of Losses arising out of substantially similar facts and circumstances, unless such item or items of Losses exceed $100,000 (the
"Designated Amount") and no claim may be made against Seller pursuant to Section 8.03(a)(i) unless the aggregate of all such Losses of the
Purchaser Indemnified Parties referred to in Section 8.03(a)(i) shall exceed $1,000,000 (the "Seller's Threshold Amount"), after which

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all indemnifiable Losses shall be payable, and not only the amount in excess of the Seller's Threshold Amount. Notwithstanding anything in this Agreement to the contrary, no Purchaser Indemnified
Party shall be indemnified pursuant to Section 8.03(a)(i) if, and to the extent that, the aggregate of all Losses of the Purchaser Indemnified Parties for which the Purchaser Indemnified
Parties previously shall have received indemnification pursuant to Section 8.03(a)(i), together with the aggregate of all amounts with respect to Taxes for which Purchaser previously shall have
received indemnification pursuant to Section 8.03(a)(i), shall have exceeded 10% of the Base Purchase Price. In addition, no claim may be
made against Seller for indemnification pursuant to this Section 8.03 with respect to any individual item of Loss, if such claim otherwise was raised (whether or not accepted) in connection
with the Purchase Price adjustment procedures set forth in Section 2.08.

(c)  Payments
by Seller pursuant to Section 8.03(a) shall be limited to the amount of any Loss that remains after deducting therefrom (i) any Tax benefit to the
Purchaser Indemnified Parties; (ii) any insurance proceeds and any indemnity, contribution or other similar payment recoverable by the Purchaser Indemnified Parties from any third party with
respect thereto (other than in respect of insurance proceeds received from the Purchaser's warranty and indemnity insurance policy in relation to this Agreement); and (iii) any reserves
provided for the item in question in the Closing Balance Sheet. A Tax benefit will be considered to be recognized by the Purchaser Indemnified Party for purposes of this Section 8.03 in the Tax
period in which the indemnity payment occurs, and the amount of the Tax benefit shall be determined by assuming that Purchaser Indemnified Party is in the maximum applicable statutory Tax bracket
after any deduction or other allowances reportable with respect to a payment hereunder.

(d)  A
Purchaser Indemnified Party shall give Seller prompt written notice of any claim, assertion, event or proceeding by or in respect of a third party of which such
Purchaser Indemnified Party has knowledge concerning any Loss as to which such Purchaser Indemnified Party may request indemnification hereunder;provided,
however, that the failure to give such notice shall not relieve Seller from any Liability or obligation pursuant to this Section 8.03 unless and only to the extent that
Seller is materially prejudiced thereby. Seller shall have the right to assume, through counsel reasonably acceptable to Purchaser, the defense or settlement of any such claim or proceeding at its own
expense. If Seller elects to assume the defense of any such claim or proceeding, Purchaser Indemnified Party may participate in such defense, but in such case the expenses of Purchaser Indemnified
Party shall be paid by Purchaser Indemnified Party. Purchaser Indemnified Party shall provide Seller with reasonable access to its records and personnel relating to any such claim, assertion, event or
proceeding during normal business hours and shall otherwise cooperate with Seller in the defense or settlement thereof, and Seller shall reimburse Purchaser Indemnified Party for all its reasonable
out-of-pocket expenses in connection therewith;provided, however, that neither Purchaser nor Seller shall be required pursuant
to this Section 8.03 to disclose any privileged information or any attorney work product. If Seller elects to assume the defense of any such claim or proceeding, Purchaser Indemnified Party
shall not pay, or permit to be paid, any part of any claim or demand arising from such asserted liability unless Seller consents in writing to such payment or unless Seller, subject to the last
sentence of this Section 8.03(d), withdraws from the defense of such asserted liability or unless a final judgment from which no appeal may be taken by or on behalf of Seller is entered against
Purchaser Indemnified Party for such liability. If Seller shall fail to undertake any such defense, Purchaser Indemnified Party shall have the right to undertake the defense or settlement thereof, at
Seller's expense. If Purchaser Indemnified Party assumes the defense of any such claim or proceeding pursuant to this Section 8.03(d) and proposes to settle such claim or proceeding prior to a
final judgment thereon or to forgo any appeal with respect thereto, then Purchaser Indemnified Party shall give Seller prompt written notice thereof and Seller shall have the right to participate in
the settlement or assume or reassume the defense of such claim or proceeding.

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(e)  Purchaser hereby acknowledges and agrees that (except in the case of fraud, in which case Purchaser reserves any and all rights and remedies available to it) its sole
and exclusive remedy with respect to any and all claims relating to the subject matter of this Agreement and the transactions contemplated hereby shall be pursuant to the indemnification provisions
set forth in the Tax Deed and in this Article VIII and specific performance as contemplated by Section 10.15. In furtherance of the foregoing, Purchaser hereby waives, to the fullest
extent permitted under applicable Law, any and all rights, claims and causes of action it may have against Seller or any of its Affiliates arising under or based upon any Law (including, without
limitation, any such rights, claims or causes of action arising under or based upon common law or otherwise) with respect to any and all claims relating to the subject matter of this Agreement and the
transactions contemplated hereby except as set forth in the preceding sentence (except in the case of fraud, in which case Purchaser reserves any and all rights and remedies available to it).

(f)    Except
as expressly set forth in this Agreement, Seller is not making any representation, warranty, covenant or agreement with respect to the Shares, the Grafts Business
or any other matter contained herein. Anything herein to the contrary notwithstanding, no breach of any representation, warranty, covenant or agreement contained herein shall give rise to any right on
the part of Purchaser, after the consummation of the purchase and sale of the Shares as contemplated hereby, to rescind this Agreement or any of the transactions contemplated hereby.

(g)  Purchaser
acknowledges that it is not aware at the date of this Agreement (or the Closing Date as applicable) of any breach of the representations and warranties given
by the Seller in Article III, except for those matters set forth in the Disclosure Letter.

(h)  Notwithstanding
anything to the contrary contained herein, Seller shall not be liable to or otherwise responsible to any other Person for consequential, incidental or
punitive damages or for diminution in value or lost profits that arise out of or relate to this Agreement or the performance or breach thereof.

ARTICLE IXTERMINATION AND WAIVER

Section 9.01Termination.This Agreement may be terminated at any time prior to the Closing:



Section 9.02Effect of Termination.(a) (i) In the event of the termination of this Agreement by
the Seller prior to the Closing pursuant to Section 9.01(b), or 9.01(e), Purchaser shall as soon as

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practicable thereafter reimburse Seller for all of its reasonably documented out-of-pocket costs and expenses (including attorney's fees) incurred in connection with this
Agreement and in pursuit of the transactions contemplated hereby in cash, by wire transfer in immediately available funds to an account designated in writing by Seller and (ii) in the event of
the termination of this Agreement by the Purchaser prior to the Closing pursuant to Section 9.01(b) or 9.01(d), Seller shall as soon as practicable thereafter reimburse Purchaser for all of its
reasonably documented out-of-pocket costs and expenses (including attorney's fees) incurred in connection with this Agreement and in pursuit of the transactions contemplated
hereby in cash, by wire transfer in immediately available funds to an account designated in writing by Purchaser;provided, however, that any failure to
satisfy the closing condition specified in Section 7.01(d) shall not result in any payment by Seller pursuant to this Section 9.02(a)(ii).

(b)  In
the event of termination of this Agreement as provided in Section 9.01, this Agreement shall forthwith become void and there shall be no further liability on
the part of any party hereto (i) except
as set forth in Section 5.02(c), Section 8.02(a) and Section 10.01, and (ii) nothing herein shall relieve either party from liability for any breach hereof.

Section 9.03Waiver.Either party hereto may (i) extend the time for the performance of any of the
obligations or other acts of the other party hereto; (ii) waive any inaccuracies in the representations and warranties of the other party contained herein or in any document delivered pursuant
hereto or; (iii) waive compliance with any of the agreements of the other party contained herein. Any such extension or waiver shall be valid only if set forth in an instrument in writing
signed by the party to be bound thereby.

ARTICLE XGENERAL PROVISIONS

Section 10.01Expense.Except as otherwise specified in this Agreement, all costs and expenses,
including, without limitation, fees and disbursements of counsel, financial advisors and accountants, incurred in connection with this Agreement and the transactions contemplated hereby shall be paid
by the party incurring such costs and expenses, whether or not the Closing shall have occurred.

Section 10.02Notices.All notices, requests, claims, demands and other communications hereunder shall be
in writing and shall be given or made (and shall be deemed to have been duly given or made upon receipt) by delivery in person, by courier service, by telecopy or by registered or certified mail
(postage prepaid, return receipt requested) to the respective parties at the following addresses (or at such other address for a party as shall be specified in a notice given in accordance with this
Section 10.02):



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Section 10.03Public Announcements.Except as required by Law or by the requirements of any securities
exchange on which the securities of a party hereto are listed, no party to this Agreement shall make, or cause to be made, any press release or public announcement in respect of this Agreement or the
transactions contemplated hereby or otherwise communicate with any news media without the prior written consent of the other party, and the parties shall cooperate as to the timing and contents of any
such press release or public announcement.

Section 10.04Headings.The descriptive headings contained in this Agreement are for convenience of
reference only and shall not affect in any way the meaning or interpretation of this Agreement.

Section 10.05Severability.If any term or other provision of this Agreement is invalid, illegal or
incapable of being enforced by any Law or public policy, all other terms and provisions of this Agreement shall nevertheless remain in full force and effect so long as the economic or legal substance
of the transactions contemplated hereby is not affected in any manner materially adverse to any party. Upon such determination that any term or other provision is invalid, illegal or incapable of
being enforced, the parties hereto shall negotiate in good faith to modify this Agreement so as to effect the original intent of the parties as closely as possible in an acceptable manner in order
that the transactions contemplated hereby are consummated as originally contemplated to the greatest extent possible.

Section 10.06Entire Agreement.This Agreement, together will all the agreements entered into pursuant
hereto, constitutes the entire agreement of the parties hereto with respect to the subject matter hereof and supersedes all prior agreements and undertakings, both written and oral, other than the
Confidentiality Agreement, with respect to the subject matter hereof.

Section 10.07Assignment; Fulfillment of Obligations.(a) This Agreement shall not be assigned
without the express written consent of Seller and Purchaser (which consent may be granted or withheld in the sole discretion of Seller and Purchaser), except that either party hereto may assign its
rights hereunder to a wholly owned subsidiary of such party;provided, however, that any such assignment shall not relieve the assigning party of its
obligations hereunder; andprovided furtherthat any assignment by Purchaser hereunder to any of its wholly owned subsidiaries shall cease to be
effective if such subsidiary ceases to be a wholly owned subsidiary of Purchaser.

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(b)  Any
obligation of any party to any other party under this Agreement, which obligation is performed, satisfied or fulfilled by an Affiliate of such party, shall be deemed
to have been performed, satisfied or fulfilled by such party.

Section 10.08No Third Party Beneficiaries.Subject to the provisions of Article VIII relating to
the Seller Indemnified Parties or the Purchaser Indemnified Parties, this Agreement shall be binding upon and inure solely to the benefit of the parties hereto and their permitted assigns and nothing
herein, express or implied, is intended to or shall confer upon any other Person any legal or equitable right, benefit or remedy of any nature whatsoever under or by reason of this Agreement. Except
as provided in Article VIII, no person who is not a party to this Agreement shall have any rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this Agreement.

Section 10.09Amendment.This Agreement may not be amended or modified except by an instrument in writing
signed by, or on behalf of, Seller and Purchaser.

Section 10.10Rights Cumulative and Other Matters.(a) Except as otherwise provided in this
Agreement, the rights, powers, privileges and remedies provided in this Agreement are cumulative and are not exclusive of any rights, powers, privileges or remedies provided by law or otherwise.

(b)  No
failure to exercise nor any delay in exercising any right, power, privilege or remedy under this Agreement shall in any way impair or affect the exercise thereof or
operate as a waiver thereof in whole or in part.

(c)  No
single or partial exercise of any right, power, privilege or remedy under this Agreement shall prevent any further or other exercise thereof or the exercise of any
other right, power, privilege or remedy.

Section 10.11Governing Law.This Agreement shall be governed by the laws of England and Wales. The
parties hereto hereby irrevocably submit to the exclusive jurisdiction of the courts of England and Wales in any action or proceeding to enforce this Agreement or arising out of or relating to this
Agreement and irrevocably waive any objection to such proceedings on the grounds of an inconvenient forum.

Section 10.12Counterparts.This Agreement may be executed in one or more counterparts, and by the
different parties hereto in separate counterparts, each of which when executed shall be deemed to be an original but all of which taken together shall constitute one and the same agreement.

Section 10.13Disclosure Letter.The parties hereto acknowledge that certain matters set forth in the
Disclosure Letter are included for informational purposes only, notwithstanding the fact that, because they do not rise above applicable materiality thresholds or otherwise, they would not be required
to be set forth therein by the terms of this Agreement and that disclosure of such matters shall not be taken as an admission by Seller or any of its Affiliates that such disclosure is required to be
made under the terms of any provision of this Agreement and in no event shall the disclosure of such matters be deemed or interpreted to broaden or otherwise amplify the representations and warranties
contained in this Agreement. Disclosure of any fact or item in a section of the Disclosure Letter shall be deemed to be disclosed with respect to any other applicable section whether or not an
explicit cross-reference appears.

Section 10.14Currency.Unless otherwise specified in this Agreement, all references to currency,
monetary values and dollars set forth herein shall mean United States (U.S.) Dollars and all payments hereunder shall be made in United States Dollars.

Section 10.15Specific Performance.The parties hereto agree that irreparable damage would occur in the
event any provision of this Agreement was not performed in accordance with the terms hereof and that
the parties shall be entitled to specific performance of the terms hereof, in addition to any other remedy at law or equity.

[Signature
Page follows]

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IN WITNESS WHEREOF, Seller, CUH, CGHG and Purchaser have caused this Agreement to be executed as of the date first written above by their respective officers thereunto duly authorized.

| |  | CENTERPULSE USA HOLDING CO.   
| |  | ------------------------------
| |  | By:                           
| |  |                               
| |  |                               
| |  | CENTERPULSE USA HOLDING CO.   
| |  | By:                           
| |  |                               
| |  |                               
| |  | By:                           
| |  |                               
| |  |                               
| |  | CENTERPULSE (UK) HOLDINGS LTD.
| |  | By:                           
| |  |                               
| |  |                               
| |  | By:                           
| |  |                               
| |  |                               

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| |  | In Respect of Section 5.07 only:
| |  | --------------------------------
| |  | CENTERPULSE AG                  
| |  | By:                             
| |  |                                 
| |  |                                 
| |  | By:                             
| |  |                                 
| |  |                                 
| |  | TERUMO CORPORATION              
| |  | By:                             
| |  |                                 
| |  |                                 

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SCHEDULE OF AFFILIATED COMPANIES

Sulzer
Cardiovascular GmbH,
a company organized under the laws of the Federal Republic of Germany

Sulzer
Vascutek USA Inc.,
a corporation incorporated in the State of Delaware

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SCHEDULE OF RELATED COMPANIES

Sulzer
Cardiovascular SA,
a company organized under the laws of France

Sulzer
Cardiovascular AG,
a company organized under the laws of Switzerland

Sulzer
Medica Canada Inc.,
a company organized under the laws of Canada

Sulzer
Cardiovascular BV,
a company organized under the laws of the Netherlands

Sulzer
Medica Australia Pty Ltd.,
a company organized under the laws of Australia

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