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  EXHIBIT 10.46    
    


EMPLOYMENT AGREEMENT  


        This Employment Agreement (the "Agreement"), dated August 1, 2005, is made by
and between Viral Genomix, Inc. (VGX Pharmaceuticals), a Delaware corporation (the "Company"), and with its principal offices at 450 Sentry
Parkway, Blue Bell, PA 19422, and Dr. C. Jo White ("Executive"), whose address is 1007 Stonebridge Road, Lower Gwynedd, PA 19002. 


 R E C I T A L S  


        WHEREAS, the Company desires to employ Executive and to have the benefit of his skills
and services, and Executive desires to accept employment with the Company, on the terms and conditions set forth herein; and 



        WHEREAS, Executive agrees to execute and shall be bound by the terms and conditions of the Non-Disclosure, Assignment of
Inventions, Non-Solicitation and Non-Compete Agreement (the "Non-Compete Agreement"), attached hereto as  Exhibit A. 


        NOW, THEREFORE, in consideration of the mutual promises, terms, covenants and conditions set forth herein and in the
Non-Compete Agreement, and the performance of each, the parties hereto, intending legally to be bound, hereby agree as follows: 


1.    Employment; Term.    


        a.     The
Company hereby agrees to employ Dr. White as Chief Medical Officer (CMO) and Executive hereby agrees to accept such employment with the Company in accordance
with the terms and conditions of this Agreement. 


        b.     The
"Term" of this Agreement shall commence on August 1, 2005 (the "Commencement
Date") and continue for a period of three (3) years from the Commencement Date; provided,  however, that the Term of this
Agreement may be terminated earlier at any time as provided in Section 7 below. 


2.    Position and Duties.    


        a.     The
Company agrees to employ Dr. White throughout the Term as CMO of the Company with such responsibilities, duties and authority as are assigned to him by the
Board of Directors (the "Board") of the Company, Chief Executive Officer or its designee. The CMO shall report to the Chief Executive Officer and/or the Board of Directors. 


        b.     Executive
shall faithfully devote his business/working time, attention and energy to the business and affairs of the Company and the performance of her duties hereunder
and to use reasonable efforts to perform such responsibilities faithfully and efficiently. 


        c.     Without
limiting the generality of the foregoing paragraph, during the Term, upon prior written consent of the Board or its designee, Executive shall be permitted to
serve on other Boards of Directors, professional associations and otherwise be involved with any family business or trust to the extent that, in the reasonable judgment of the Board or its designee,
such other business pursuits and activity do not materially (i) interfere with Executive's ability to discharge Executive's duties and responsibilities to the Company, whether or not such
activity is pursued for gain, profit or other pecuniary advantage, or (ii) violate the Conflicts provision of Executive's Non-Compete Agreement. 


3.    Compensation.    


        a.     Executive
shall be entitled to receive as compensation for his employment a base annual salary at a rate of $200,000 per annum (the "Base
Salary") which shall be paid to Executive by the Company or any of its affiliates on a monthly basis. 


        b.     Increases
in the Base Salary shall be reviewed annually by the Board during the Term and any such increases, if any, will be at the Board's or its designee's sole
discretion and will otherwise be consistent with the Company's annual policies and budget for payroll increases. 







 

4.    Bonus.    


        During
the Term, Executive shall be eligible to receive an incentive cash bonus up to the amount, based upon the criteria, and payable at such times, as may be determined by the Board
and targeted at twenty percent (20%) or more of the Base Salary. The amount shall be determined by the Board, in its sole and absolute discretion, which shall be binding and final, and shall be paid
in a lump sum payment (less payroll taxes). Upon execution of this Agreement, ten percent (10%) of Base Salary bonus will be paid immediately. To the extent that such cash bonus is to be determined in
light of financial performance during a specified fiscal period and the Agreement commences on a date after the start of such fiscal period, any cash bonus payable in respect of such fiscal period's
results may be prorated. In addition, if the period of Executive's employment hereunder expires before the end of a fiscal period, and if Executive is eligible to receive a cash bonus at such time
(such eligibility being subject to the restrictions set forth in Section 7 below), any cash bonus payable in respect of such fiscal period's results may be prorated. 


5.    Benefits; Stock Options and Vacation.    


        In
addition to the salary and cash bonus referred to above, Executive shall be entitled during the Term to participate in such employee benefits plans or programs of the Company, and
shall be entitled to such other fringe benefits, as are from time to time adopted by the Board and made available by the Company generally to employees of Executive's position, tenure, salary, age,
health and other qualifications. Without limiting the generality of the foregoing, Executive shall be eligible for such awards, if any, under the Company's employee benefits plans or programs as shall
be granted to Executive in the sole discretion of the Board or its designee. Executive acknowledges and agrees that
the Company does not guarantee the adoption or continuance of any particular employee benefits plan or program or other fringe benefits during the Term, and participation by Executive in any such plan
or program shall be subject to the rules and regulations applicable thereto. 



        a.     On
or about August 1, 2005, by Sole Director's Written Consent of Viral Genomix, Inc., the Executive was elected as CMO. The Board Resolution granted
Dr. White options to purchase Three Hundred Thousand (300,000) shares of Common Stock of the Company. Upon execution of this Agreement by the Executive and the Company, the Executive will be
awarded Three Hundred Thousand (300,000) Incentive Stock Options (ISO) to purchase Common Shares of the Company's Stock at a strike price of $0.25 per share pursuant to an Option Grant Agreement in
substantially the form attached hereto as Exhibit B over three years. These options are subject to the rules and regulations of the 2001 Equity
Incentive Plan. In addition, all shares of the Company's stock will be subject to those restrictions contained in the anticipated future Company's Stockholder's Agreement. 


        b.     In
addition, the Executive is entitled 25 business days (5 weeks) as a Company paid vacation days annually. The Executive will have an office and a dedicated
laptop to improve Executive ability to concentrate at work, and increase her productivity. 


6.    Expenses.    


        The
Company will reimburse Executive, in accordance with the practices in effect from time to time for other officers or staff personnel of the Company, for all reasonable and necessary
business and traveling expenses and other disbursements incurred by Executive for or on behalf of the Company in the performance of Executive's duties hereunder, upon presentation by Executive to the
Company of appropriate vouchers and supporting documentation. 


7.    Termination.    


        Executive's
employment by the Company pursuant hereto is subject to termination as follows: 


        a.    Death or Disability.    The Company may by written notice to Executive or her personal representative terminate
Executive's employment on account of her death or total disability. In the case 


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of
Executive's death, Executive's employment shall be deemed to terminate on the date of Executive's death. For purposes hereof, Executive shall be deemed to experience a
"Total Disability" if Executive is considered totally disabled under any group disability plan maintained by the Company and in effect at
that time, or in the absence of any such plan, Executive shall be deemed to experience a Total Disability if she shall have been unable to perform his duties hereunder on a full-time basis
for 90 consecutive days or longer, or for shorter periods aggregating 120 days in any 360-day period. In the event of any dispute under this Section 7(a), Executive shall
submit to a physical examination by a licensed physician mutually satisfactory to the Company and Executive, the cost of such examination to be paid by the Company, and the determination of such
physician shall be determinative. In the case of a Total Disability, until the Company shall have terminated Executive's employment hereunder in accordance with the foregoing, Executive shall be
entitled to receive compensation provided for herein notwithstanding any such Total Disability. In the event of the termination of Executive's employment on account of her death or such Total
Disability, such termination shall be effective immediately upon notice, in which case Executive or her representative will have no rights or claims against the Company under this Agreement except as
follows: 



        (i)    Executive
(or her estate or representative, as applicable) shall be paid (A) any unpaid portion of his Base Salary computed on a pro
rata basis through the date of her termination and (B) any unreimbursed expenses; 


        (ii)   All
other of Executive's accrued but unpaid rights shall be as determined under any incentive compensation, stock option, retirement, employee welfare or other employee
benefits plan or program of the Company in which Executive is then participating at the time of her termination; and 


        (iii)  in
the case of Executive's Total Disability only, (A) the Company shall continue Executive's medical benefits coverage existing at the time of her termination
for as long as permissible under the Company's health benefits policies (not to exceed 60 days) and the Company further agrees to pay Executive's COBRA premiums for 6 months thereafter,
with such premiums to provide for coverage at the same level and subject to the same terms and conditions (including, without limitation, any applicable co-pay obligations of Executive,
but excluding any applicable tax consequences for Executive) as in effect for Executive at the time of termination, and (B) Executive shall further receive a lump-sum payment,
within 15 days after the effective date of termination, equal to the aggregate amount of Executive's Base Salary as in effect immediately prior to such termination that would be payable over a
period of 6 months following the effective date of such termination. 




        b.    Involuntary Termination for Cause.    In the event the Company terminates Executive's employment for Cause (as
such term is defined below), such termination ("Termination For Cause") shall be effective immediately upon notice thereof, in which case Executive will
have no rights or claims against the Company under this Agreement except as follows: 



        (i)    Executive
shall be paid (A) any unpaid portion of her Base Salary computed on a pro rata basis through the date of
her termination and (B) any unreimbursed expenses; and 


        (ii)   All
other of Executive's accrued but unpaid rights shall be as determined under any incentive compensation, stock option, retirement, employee welfare or other employee
benefits plan and program of the Company in which Executive is then participating at the time of her termination. 




        "Cause" shall mean: (1) conviction of Executive of any felony; (2) participation by Executive in any fraud or act of
dishonesty against the Company; (3) material violation by Executive of (i) any contract between the Company and Executive, or (ii) any statutory duty of Executive to the Company;
(4) conduct of Executive that, based upon a good faith and reasonable factual investigation and 


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determination
by the Board, demonstrates Executive's gross unfitness to serve; or (5) the continued, willful refusal or failure by Executive to perform any material duties reasonably requested
by the Board and/or Chief Executive Officer; provided, however, that in the case of conduct described in
clauses (3), (4) and (5) hereof, such conduct shall not constitute "Cause" unless (a) the Board shall have given Executive written notice setting forth with specificity
(i) the conduct deemed to constitute "Cause," (ii) reasonable action that would remedy the objectionable conduct and (iii) a reasonable time (not less than 10 days) within
which Executive may take such remedial action, and (b) Executive shall not have taken such specified remedial action within such specified reasonable time. 


        c.    Involuntary Termination Without Cause.    The Company may terminate Executive's employment, other than on
account of death, Total Disability or for Cause, on 30 days written notice ("Termination Without Cause"), in which case Executive will have no
rights or claims against the Company under this Agreement except as follows: 



        (i)    Executive
(or her estate or representative, as applicable) shall be paid (A) any unpaid portion of her Base Salary computed on a pro
rata basis through the date of her termination, and (B) any unreimbursed expenses; 


        (ii)   All
other of Executive's accrued but unpaid rights shall be as determined under any incentive compensation, stock option, retirement, employee welfare or other employee
benefits plan and program of the Company in which Executive is then participating at the time of her termination; 



        (iii)  Executive
shall receive severance payments in the form of monthly payments of Executive's Base Salary (as in effect immediately prior to such termination) and of the
Pro Rata Bonus Amount (as such term is defined below) for a period of 6 months following the effective date of such termination; and 


        (iv)  The
Company shall continue Executive's medical benefits coverage existing at the time of her termination for as long as permissible under the Company's health benefits
policies (not to exceed 60 days) and the Company further agrees to pay Executive's COBRA premiums for 6 months thereafter,
with such premiums to provide for coverage at the same level and subject to the same terms and conditions (including, without limitation, any applicable co-pay obligations of Executive,
but excluding any applicable tax consequences for Executive) as in effect for Executive at the time of termination.. 




        For
the purposes of this Agreement, "Pro Rata Bonus Amount" shall mean one-twelfth (1/12th) of the greater of
(A) the most recent annual cash bonus paid to Executive prior to the date of her termination, or (B) the average of the three most recent annual cash bonuses paid to Executive prior to
the date of his termination. The rights of Executive and the obligations of the Company under this Section 7(c) shall remain in full force and effect notwithstanding the expiration of the Term,
whether by failure of the Board to extend such Term or otherwise, and the failure of the Board to extend such Term shall be deemed a Termination Without Cause under this Section 7(c). 


        d.    Voluntary Termination For Good Reason.    Executive may terminate her employment for good reason
("Termination For Good Reason") upon 30 days written notice. In the event of Termination for Good Reason, Executive shall be entitled to receive
the payments and other rights provided in Section 7(c) hereof. For purposes of this Agreement, termination for "Good Reason" shall mean voluntary
termination by Executive of her employment with the Company based on one of the following events: 



        (i)    the
material diminution in Executive's position, title, responsibilities or authority from those in effect at the Commencement Date; 


        (ii)   the
breach by the Company of any of its material obligations under this Agreement. 



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        e.    Voluntary Termination.    Executive may otherwise terminate her employment without Good Reason upon
30 days written notice, in which case Executive (or his estate or representative, as applicable) shall be paid (A) any unpaid portion of her Base Salary on a pro
rata basis through the date of the termination, and (B) any unreimbursed expenses. 



        f.    Forfeiture of Rights.    In the event that, subsequent to termination of Executive's employment hereunder,
Executive breaches any of the provisions of the Non-Compete Agreement in any material respect, all payments and benefits to which Executive may otherwise have been entitled to pursuant to
this Section 7 hereof shall immediately terminate and be forfeited. 


8.    Remedies.    


        In
addition to other remedies provided by law or equity, upon a breach by Executive of any of the covenants contained herein or in the Non-Compete Agreement, the Company
shall be entitled to have a court of competent jurisdiction enter an injunction against Executive enjoining Executive and prohibiting any further breach of the covenants contained herein. Executive
acknowledges that a breach or threatened breach by Executive of the provisions of this Agreement will cause irreparable damage to the Company because Executive's services to be performed hereunder are
of a unique, special and extraordinary character. Thus, the Company shall be entitled to injunctive relief without the necessity of proving actual damages and the Company shall not be required to post
a bond or other security in support of such injunctive relief. 


9.    Arbitration.    



        Any
claim, dispute or controversy arising out of or in connection with this Agreement, or any breach thereof, shall be arbitrated by the parties before a sole arbitrator (who shall have
substantial experience in the pharmaceutical and life sciences industry) conducted in accordance with the National Rules for the Resolution of Employment Disputes of the American Arbitration
Association then in effect. The arbitrator shall have the authority to order discovery but shall not have the authority to add to, detract from or modify any provision hereof nor to award punitive
damages to any injured party. A decision by the sole arbitrator shall be final and binding. Judgment may be entered on the arbitrator's award in any court having jurisdiction. The direct expense of
any arbitration proceeding shall be borne by the Company. Each party shall bear its own counsel fees. Such arbitration shall take place in Philadelphia, Pennsylvania. The parties hereto consent to the
jurisdiction of the state and federal courts located in the Commonwealth of Pennsylvania with respect to any action arising under this Agreement. Notwithstanding the foregoing, the Company shall be
entitled to seek injunctive or other equitable relief, as contemplated by Section 10 hereof, from any court of competent jurisdiction, without the need to resort to arbitration. 


10.    Assignment; Binding Nature.    


        This
Agreement shall be binding upon and inure to the benefit of the parties and their respective successors, heirs (in the case of Executive) and permitted assigns. No rights or
obligations of the Company under this Agreement may be assigned or transferred by the Company except that such rights or obligations may be assigned or transferred to the successor of the Company or
its business if the assignee or transferee assumes all of the liabilities, obligations and duties of the Company, as contained in this Agreement, either contractually or as a matter of law. If any
such successor of the Company or its business does not agree to so assume such liabilities, obligations and duties, Executive may immediately resign, which shall be deemed a Termination For Good
Reason under the provisions of this Agreement. No rights or obligations of Executive under this Agreement may be assigned or transferred by Executive other than Executive's rights to compensation and
benefits, which may be transferred only by will or operation of law, except as otherwise specifically provided or permitted hereunder. 


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11.    Notice.    


        Any
notice (including notice of a change of address) permitted or required to be given pursuant to the provisions of this Agreement shall be in writing and sent by certified mail,
postage pre-paid, return receipt requested, or by hand delivery to the parties at the following addresses: 



If to the Company:


Viral
Genomix, Inc.

450 Sentry Parkway East

Blue Bell, PA 19422

Attention: Corporate Secretary 


With a copy to:


If to the Executive:


Dr. C.
Jo White

1007 Stonebridge Road

Lower Gwynedd, PA 19002. 




        Notice
properly given by mail shall be deemed effective three business days after mailing, and if hand-delivered, upon receipt. 


12.    Entire Agreement.    


        This
Agreement and the Non-Compete Agreement constitute the complete agreements and understandings between the Company and Executive concerning Executive's employment by the
Company, and supersede any and all previous agreements or understandings concerning such employment, whether written or oral, between Executive and the Company. 


13.    Modification.    


        This
Agreement may not be waived, amended or modified without the express written consent of the party against whom enforcement of such Agreement is sought. 


14.    Waiver.    


        Except
as set forth herein, no delay or omission to exercise any right, power or remedy accruing to any party shall impair any such right, power or remedy or shall be construed to be a
waiver of or an acquiescence to any breach hereof. No waiver by either party of any breach by the other party of any condition or provision contained in this Agreement to be performed by such other
party shall be deemed a waiver of a similar or dissimilar condition or provision at the same or any prior or subsequent time. Any waiver must be in writing and signed by Executive and the Chairman of
the Board. 


15.    Invalidity of Any Provision.    


        If
any portion of this Agreement is held invalid or inoperative, the other portions of this Agreement shall be deemed valid and operative and, so far as is reasonable and permitted by
the law, effect shall be given to the intent manifested by the portion held invalid or inoperative. 


16.    Applicable Law.    



        This
Agreement shall be governed by and construed in accordance with the laws of the Commonwealth of Pennsylvania, without regard to the principles of conflict of laws thereof. 


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17.    Counterparts.    


        This
Agreement may be executed simultaneously in any number of counterparts, each of which shall be deemed an original but all of which together shall constitute one and the same
agreement. 


18.    Headings.    


        The
Section headings contained in this Agreement are for reference purposes only and will not affect in any way the meaning or interpretation of this Agreement. 


19.    Binding Effect.    



        The
provisions of this Agreement will be binding upon, and will inure to the benefit of, the respective heirs, legal representatives and successors of the parties thereto. 


20.    Termination of Other Agreements.    


        The
execution of this Agreement by Viral Genomix and the Executive terminates and voids for all purposes any other Agreements, if any, between the parties. 


[SIGNATURE PAGE FOLLOWS]


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        IN WITNESS WHEREOF, the parties hereto have executed this Employment Agreement as of the date first written above. 



					
	 	 	 VIRAL GENOMIX, INC.
	

 	
 	
By:	
 	
/s/ J. Joseph Kim







 
	 	 	Name:	 	J. Joseph Kim, Ph.D.
	 	 	Title:	 	President & CEO
	

 	
 	
 EXECUTIVE:
	

 	
 	
/s/ C. Jo White






  Dr. C. Jo White





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 FIRST AMENDMENT TO THE EMPLOYMENT AGREEMENT DATED

AUGUST 1, 2005  


        This is the First Amendment ("Amendment") to the Employment Agreement between VGX Pharmaceuticals, Inc. ("VGX") and C. Jo. White
("Executive") dated as of 20th day of August, 2008 (the "Effective Date"), amending the Employment Agreement ("Agreement") dated August 1, 2005 between VGX and Executive.
All undefined terms contained herein shall have the meaning set forth in the Agreement. 


        WHEREAS,
both parties wishes to amend the Agreement as follows: 


        NOW,
THEREFORE, for good and valuable consideration and intending to be legally bound, the parties hereby agree as follows: 



	1.
	The
base annual salary the Executive is entitled to receive for his employment is $216,300.00 per annum



	2.
	Executive
is entitled to 30 business days (6 weeks) as a Company paid vacation days annually. 





							
	Dr. C. Jo. White

1007 Stonebridge Road

Lower Gwynedd, PA, 19002	 	VGX Pharmaceuticals

450 Sentry Parkway

Blue Bell, PA 19422

Telephone: 267-440-4205
	 	 	 	 	 	 	 
	/s/ C. Jo. White






  C. Jo. White

Chief Medical Officer	 	/s/ Gene J. Kim






  Gene J. Kim

Chief Financial Officer
	
 Date:	
 	
August 20, 2008	
 	
Date:	
 	
August 20, 2008





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EXHIBIT 10.46