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Exhibit 10.22
 State of South Carolina
    
    
    )County of Greenville
    
    
    )
 LEASE AGREEMENT, OPTIONS TOPURCHASE AND OPTION TO LEASE
 THIS LEASE AGREEMENT th
 WITNESSETH:
 Exhibit C
  Exhibit
E
   ARTICLE I  GRANT AND TERM
 1.01 Premises Exhibit B Exhibit C Exhibit
C
 Exhibit A
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1.02 Initial Term
 1.03 Base Term
  1.04 Delivery of Demised Premises
 ARTICLE II  RENT
 2.01 a. Payment of Rent.
 2.01 b. Rent During Base Term.
 2.01 c. Rent During Extension Term
 2.02 Additional Rent.
 a. Taxes
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b. Reimbursement of Landlords Cost of Insurance
 c. Other Additional Rent Provisions
 2.03 Additional Rent Estimated and Paid Monthly
 2.04 Estimated Additional Rent for Year 1
 2.05 Penalty
 2.06 Tenants Proportionate Share Exhibit A,  Exhibit
A
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ARTICLE III  HOLDING OVER
 3.01 Rent for Holding Over Period
 ARTICLE IV  TAXES/ASSESSMENTS
 4.01 Real Property Taxes
 4.02 Personal Property Taxes
 ARTICLE V  INSURANCE
 5.01 Required Coverage by Tenant.
 a. Landlords Insurance.
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b. Tenants Insurance.
   ARTICLE VI  INDEMNIFICATION
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ARTICLE VII  MAINTENANCE OF PREMISES
 7.01 Repairs by Landlord
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7.02
Repairs by Tenant .
 7.03 Maintenance of Grounds and Parking, Driveways Exhibit
C
 7.04 Alterations and Remodeling
   -7-




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7.05 Compliance with Regulations.
 7.06 Tenants Right to Contest Regulations
 7.07 Satellite Dish
 7.08 Utilities.
 ARTICLE IX  USE AND CONDUCT OF BUSINESS
 9.01 Use of the Premises
 9.02 Nuisance
 ARTICLE X  QUIET ENJOYMENT
 10.01
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ARTICLE XI  ENVIRONMENTAL
 11.01 Landlords Environmental Warranty
 11.02 Hazardous Waste
 11.03 Other
 ARTICLE XII  SIGNAGE
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ARTICLE XIII  DESTRUCTION
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ARTICLE XIV  CONDEMNATION
 Exhibit C
 ARTICLE XV  DEFAULT
 15.01 Default by Tenant
    15.02 Landlords Remedies
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15.03 Waiver of Lien
 15.04 Landlords Default
 ARTICLE XVI  BANKRUPTCY OR INSOLVENCY
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ARTICLE XVII  TENANTS RIGHT TO SUBLEASE AND ASSIGN
 17.01
 17.02 Violation
 ARTICLE XVIII  LANDLORDS RIGHT TO MORTGAGE AND SELL
 18.01 Estoppel Certificate
 18.02 Subordination and Attornment
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18.03 Transfer of Landlords Interest
 ARTICLE XIX  SURRENDER OF PREMISES
 19.01 Trade Fixtures
 19.02 Surrender
 ARTICLE XX  SECURITY DEPOSIT
 20.01
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ARTICLE XXI  MISCELLANEOUS
 21.01 Landlords Entry
 21.02 Nature and Extent of Agreement
 21.03 Partial Invalidity
 21.04 Recording
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21.05 Calculation of Time
 21.06 Landlords Right to Perform Tenants Covenants
 a.
    
    pay any taxes or other charges payable by Tenant pursuant to the provisions of
Article IV, orb.
    
    take out, pay for and maintain any of the insurance policies required by Tenantc.
    
    make any other payment or perform any other act on Tenants part to be made or
performed as in this Lease provided.
 21.07 Statement of Lease Commencement Date.
 21.08 Waiver
 21.09 Reasonable Consent Provisions
 21.10 Applicable Law
 21.11 Notices
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By Tenant to Landlord:EZE Management Properties Limited PartnersP.O. Box 6648Greenville, SC 29606Attn: J. Carroll RushingBy Landlord to Tenant:Rockwell Medical Technologies, Inc.30142 Wixom RoadWixom, MI 48393Attn: Thomas Klema
 21.12 Captions
 21.13 Binding Effect
 21.14 Duplicate Counterparts
 21.15 Brokers Representation
 21.16 Force Majeure .
 21.17 Additional Documents.
 21.18 Improvements by Landlord. Exhibit F
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ARTICLE XXII  OPTIONS TO PURCHASE
 22.01 Options. Exhibit E
 22.02 Purchase Price.
 22.03 Costs and Prorations.
 22.04 Closing.
 22.05 Destruction of Improvements.
 22.06 Option Remedies.
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ARTICLE XXIII  OPTION TO LEASE OFFICE BUILDING
 23.01 Option.
 23.02 Term.
 23.03 Base Rent.
 23.04 Additional Rent.
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IN WITNESS WHEREOF th
 LANDLORD: EZE
Management Properties Limited PartnersBy:
    /s/ J. Carroll RushingJ. Carroll RushingIts:  ChairmanDate of Execution: March 19, 2008TENANT:  Rockwell Medical Technologies, Inc.By:

/s/ Thomas E. KlemaThomas E. KlemaIts:  Chief Financial OfficerDate of Execution: March 19, 2008 -20-




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EXHIBIT A  SURVEY
 
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EXHIBIT B  FLOOR PLAN
 
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EXHIBIT C  BUILDING SITE PLAN
 
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EXHIBIT
D
 604 HIGH TECH COURT
 ESTIMATED SUMMARY OF RENT FOR YEAR 1
 ANNUAL
    
    
    MONTHLYBASE RENTYear 1
    
    $
    275,628.00
    
    
    $
    22,969.00ADDITIONAL RENTReal estate taxes ($0.637/sf)
    
    $
    36,348.00
    
    
    $
    3,029.00Insurance
    
    $
    8,244.00
    
    
    $
    687.00TOTAL ESTIMATED RENT FOR YEAR 1
    
    $
    320,220.00
    
    
    $
    26,685.00
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EXHIBIT E
 OFFICE SITE PLAN
 
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EXHIBIT F
 IMPROVEMENTS, APPROVED BY TENANT,  TO BE MADE BY LANDLORD
 Rockwell Medical Technologies, Inc.
604 High Tech Court, Greer, SC 29650
Plant Upgrades
 Construction of new liquid filling and powder filling area as designed,
along with first truck entrance curb improvements.
 Item
    
    Item CostConcrete, Curb, Trench, Demo
    
    $
    10,150.00Metal Framing, Drywall, Ceiling
    
    
    42,000.00Plumbing
    
    
    8,385.00HVAC
    
    
    31,690.00Electrical
    
    
    11,100.00Overhead Doors
    
    
    4,500.00Sump Drain Covers
    
    
    700.00Personnel Doors, Materials, Labor
    
    
    3,900.00Urethane Floor
    
    
    3,600.00Sprinkler
    
    
    3,750.00Paint
    
    
    9,000.00Windows
    
    
    600.00Bollards
    
    
    1,800.00Project Overhead, Supervision, Project Management
    
    
    36,446.00167,621.00Architect Fees
    
    
    1,917.00$
    169,538.00
 -26-