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 In this section:

                Development & Approval Process

Development & Approval Process

                        Environmental Impact Considerations
          Food Additive Petitions for Animal Food
          Public Master Files (PMFs) Supporting Applications for Major Use and Major Species Drugs
          Veterinary Feed Directive (VFD)
          Veterinary Master Files


                        Abbreviated New Animal Drug Applications
          Modernizing FDA’s and EPA’s Approach to Oversight of Products for Animals Regulated as Pesticides or New Animal Drugs
          Aquaculture
          Biotechnology Products at CVM: Animals and Animal Food
          Electronic Submissions
          Minor Use/Minor Species
          New Animal Drug Applications
          User Fees Home
          Animal & Veterinary
          Development & Approval Process
          Veterinary Feed Directive (VFD)Development & Approval Process Veterinary Feed Directive (VFD)
  
  	
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    PrintThe Food and Drug Administration (FDA) has amended the new animal drug regulations to implement the veterinary feed directive (VFD) drugs section of the Animal Drug Availability Act of 1996 (ADAA). On June 3, 2015, the FDA published in the Federal Register the final rule revising the VFD regulations in 21 CFR Part 558. The final rule became effective on October 1, 2015. In March 2019, FDA published a draft revised Guidance for Industry #120 that enhances and expands upon the previous version released in September 2015. These changes were made in response to stakeholder feedback and comments submitted to FDA’s Center for Veterinary Medicine (CVM) since the VFD final rule went into effect and the implementation of Guidance for Industry #213.

A VFD drug is intended for use in animal feeds, and such use of the VFD drug is permitted only under the professional supervision of a licensed veterinarian.

Final Rule

FACT SHEET: Veterinary Feed Directive Final Rule and Next Steps
	Placing Animal Drugs under Veterinarian Oversight: Questions and Answers with Michael Taylor and William Flynn
	Guidance for Industry #120 Veterinary Feed Directive Regulation Questions and Answers
	Drugs with Veterinary Feed Directive (VFD) Marketing Status
	Summary Assessment of Veterinary Feed Directive Compliance Activities Conducted in Fiscal Years 2016–2018
	Veterinary Feed Directive - an Overview (video)
	Veterinary Feed Directive for Veterinarians (video)
	Veterinary Feed Directive for Feed Distributors (video)
	Veterinary Feed Directive for Animal Producers (video)Federal Register Notices

Final Rule: Veterinary Feed Directive
	Notice of Availability of Draft Revised Guidance for Industry: Veterinary Feed Directive Regulation Questions and Answers
	Veterinary Feed Directive Docket
	Final Rule: New Animal Drugs; FlorfenicolGuidance Documents

CVM GFI #120 Veterinary Feed Directive Regulation Questions and Answers
	CVM GFI #233 Veterinary Feed Directive Common Format Questions and AnswersQuestions and Answers

Using Medically Important Antimicrobials in Bees - Questions and Answers
	Questions and Answers: FDA Approved Free-Choice Feeding Options for Anaplasmosis Control in CattleState or Federal VCPR

Does the State or Federal VCPR Definition Apply to a Lawful VFD in my State?Veterinary Feed Directive Brochures

Veterinary Feed Directive Producer Requirements
	Veterinary Feed Directive Requirements for Distributors (Who Manufacture VFD Feed)
	Veterinary Feed Directive Requirements for Distributors (Who Do Not Manufacture VFD Feed)
	Veterinary Feed Directive Requirements for Veterinarians
	Veterinary Feed Directive Requirements for Veterinarians - For Veterinary StudentsVeterinary Feed Directive Brochures in Spanish

Directiva de alimentos veterinarios (VFD, por sus siglas en ingles) - Requisitos del productor
	Directiva de Alimentos Veterinarios (VFD) - Requisitos para los distribuidores (que producen alimentos VFD)
	Directiva de Alimentos Veterinarios (VFD) - Requisitos para los distribuidores (Que no producen alimentos VFD)
	Directiva de Alimentos Veterinarios (VFD) - Requisitos para veterinarios
	Directiva de Alimentación Veterinaria (VFD) - Requisitos para veterinarios (Para estudiantes de veterinaria)Listing of Veterinary Feed Directive Distributor Notifications

See Animal Drugs @ FDA, under the Medicated Feeds section, for current listings. Lists are available in PDF and Excel formats. Updates to the lists are made as notifications are processed.

Additional Resources

Medicated Feeds
	Blue Bird Labels
	Veterinary Feed Directive: Reference List
	Medically Important Antimicrobials in Animal Agriculture - Honey Bees - Presentation
	Fostering Antimicrobial Stewardship In Animals - Presentation

                                                                                  Content current as of:
      01/03/2024Development & Approval Process

          
                        Environmental Impact Considerations
          Food Additive Petitions for Animal Food
          Public Master Files (PMFs) Supporting Applications for Major Use and Major Species Drugs
          Veterinary Feed Directive (VFD)
          Veterinary Master Files


                        Abbreviated New Animal Drug Applications
          Modernizing FDA’s and EPA’s Approach to Oversight for Animal Products
          Aquaculture
          Biotechnology Products at CVM: Animals and Animal Food
          Electronic Submissions
          Minor Use/Minor Species
          New Animal Drug Applications
          User Fees
 
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