EXHIBIT 10.1


 


CONFIDENTIAL TREATMENT


 


EPIX Medical,
Inc. has requested that the marked portions of this document be accorded
confidential treatment pursuant to Rule 24b-2 under the Securities Exchange Act
of 1934.


 


Final
Version


 


THROMBUS
DEVELOPMENT AGREEMENT


 


between


 


EPIX MEDICAL, INC.


 


and


 


SCHERING AKTIENGESELLSCHAFT


 

















 


TABLE
OF CONTENTS


 


	
  ARTICLE
  1:

  	
  DEFINITIONS

  
	
   

  	
   

  
	
  ARTICLE
  2:

  	
  THE PROOF OF CONCEPT DEVELOPMENT PROGRAM

  
	
  2.1.

  	
  General

  
	
  2.2.

  	
  Conduct of the Proof of Concept Development
  Program

  
	
  2.3.

  	
  Proof of Concept Plan

  
	
  2.4.

  	
  Development Information

  
	
  2.5.

  	
  Availability to Employees

  
	
   

  	
   

  
	
  ARTICLE
  3:

  	
  PROOF OF CONCEPT DEVELOPMENT PROGRAM
  FUNDING

  
	
  3.1.

  	
  Funding Commitment

  
	
   

  	
   

  
	
  ARTICLE
  4:

  	
  LICENSE
  OPTION

  
	
  4.1.

  	
  Schering’s Development Option

  
	
   

  	
   

  
	
  ARTICLE
  5:

  	
  LICENSES

  
	
  5.1.

  	
  License
  Grants

  
	
  5.2.

  	
  Retained
  Rights

  
	
  5.3.

  	
  Diligence

  
	
  5.4.

  	
  Labeling and Packaging

  
	
  5.5.

  	
  Reports and Forecasts

  
	
   

  	
   

  
	
  ARTICLE
  6:

  	
  LICENSE
  PAYMENTS

  
	
  6.1.

  	
  Schering License Terms

  
	
  6.2.

  	
  EPIX License Terms

  
	
   

  	
   

  
	
  ARTICLE
  7:

  	
  GENERAL PAYMENT TERMS

  
	
  7.1.

  	
  Payment Dates and Reports

  
	
  7.2.

  	
  Payments; Currency Conversion

  
	
  7.3.

  	
  Records; Audit Rights; Disputes

  
	
  7.4.

  	
  Withholding
  Taxes

  
	
   

  	
   

  
	
  ARTICLE
  8:

  	
  INTELLECTUAL PROPERTY

  
	
  8.1.

  	
  Inventorship

  
	
  8.2.

  	
  Ownership

  
	
  8.3.

  	
  Filing, Prosecution, Maintenance,
  Enforcement and Defense

  
	
   

  	
   

  
	
  ARTICLE
  9:

  	
  CONFIDENTIALITY

  
	
  9.1.

  	
  Nondisclosure Obligations

  
	
  9.2.

  	
  Terms of this Agreement

  
	
  9.3.

  	
  Publications

  
	
  9.4.

  	
  Injunctive
  Relief

  
	
   

  	
   

  
	
  ARTICLE
  10:

  	
  REPRESENTATIONS AND WARRANTIES

  
	
  10.1.

  	
  Representations
  and Warranties

  
	
  10.2.

  	
  Organization

  



 


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  10.3.

  	
  Authorization

  
	 
	
  10.4.

  	
  No Inconsistent Obligation

  
	 
	
  10.5.

  	
  Warranty Disclaimer

  
	 
	
   

  	
   

  
	 
	
  ARTICLE
  11:

  	
  INDEMNITY

  
	 
	
  11.1.

  	
  Claim

  
	 
	
  11.2.

  	
  Schering Indemnity Obligations

  
	 
	
  11.3.

  	
  EPIX Indemnity Obligations

  
	 
	
  11.4.

  	
  Procedure

  
	 
	
  11.5.

  	
  Limited
  Liability

  
	 
	
   

  	
   

  
	 
	
  ARTICLE 12:

  	
  EXPIRATION AND TERMINATION

  
	 
	
  12.1.

  	
  Term

  
	 
	
  12.2.

  	
  Termination without Cause

  
	 
	
  12.3.

  	
  Termination for Material Breach

  
	 
	
  12.4.

  	
  Termination for Failure of Schering to use
  Due Diligence

  
	 
	
  12.5.

  	
  Effects Termination on Sublicenses

  
	 
	
  12.6.

  	
  Termination Upon Insolvency

  
	 
	
  12.7.

  	
  Rights in Bankruptcy

  
	 
	
  12.8.

  	
  Accrued Rights; Surviving Obligations

  
	 
	
   

  	
   

  
	 
	
  ARTICLE 13:

  	
  MISCELLANEOUS

  
	 
	
  13.1.

  	
  Force
  Majeure

  
	 
	
  13.2.

  	
  Assignment

  
	 
	
  13.3.

  	
  Severability

  
	 
	
  13.4.

  	
  Notices

  
	 
	
  13.5.

  	
  Applicable
  Law

  
	 
	
  13.6.

  	
  Dispute Resolution

  
	 
	
  13.7.

  	
  Public Announcements

  
	 
	
  13.8.

  	
  Entire Agreement; Amendment

  
	 
	
  13.9.

  	
  Headings

  
	 
	
  13.10.

  	
  Agreement Not to Solicit Employees

  
	 
	
  13.11.

  	
  Exports

  
	 
	
  13.11.

  	
  Waiver

  
	 
	
  13.12.

  	
  Counterparts

  
	 
	
  13.13.

  	
  Independent Contractors; Negation of
  Partnership

  
	 
	
  13.14.

  	
  Ambiguities

  
	 
	
   

  	
   

  
	
  Exhibit 1.12

  	
   

  	
  Structure
  of EP-2104R

  
	
  Exhibit 1.14

  	
   

  	
  EPIX Patent Rights

  
	
  Exhibit 1.42

  	
   

  	
  Schering Patent Rights

  
	
  Exhibit 2.1

  	
   

  	
  Deliverables

  
	
  Exhibit 3.1

  	
   

  	
  EPIX Budget Plan EP-2104R

  
					



 


iii

















 


THROMBUS
DEVELOPMENT AGREEMENT


 


THIS THROMBUS
DEVELOPMENT AGREEMENT dated as of May 26, 2003 (the “Agreement”) is made by and
between EPIX Medical, Inc., a Delaware corporation having its principal place
of business at 71 Rogers Street, Cambridge, Massachusetts 02142-1118 USA
(“EPIX”), and Schering Aktiengesellschaft, a German corporation having its
principal place of business at 13342, Berlin, Germany (“Schering”).


 


RECITALS


 


WHEREAS, EPIX
has expertise in and owns, or otherwise Controls, certain technology for the
development of enhancers for magnetic resonance imaging of thrombi;


 


WHEREAS,
Schering has expertise in and owns, or otherwise Controls, certain technology
for the development and commercialization of magnetic resonance imaging and
desires to fund EPIX’s next stage efforts to develop the Thrombus Compound(s)
and desires to obtain certain rights to an exclusive license to pursue late
stage development of the Thrombus Compound(s) and to develop and sell Licensed
Products worldwide in accordance with the terms and conditions of this
Agreement; and


 


WHEREAS, EPIX
is willing to perform such development work and grant to Schering such license
rights upon the terms and conditions set forth below.


 


NOW THEREFORE,
in consideration of the premises and of the covenants contained herein, the
Parties hereto mutually agree as follows:


 


ARTICLE 1:  DEFINITIONS


 


For purposes
of this Agreement, the terms defined in this Article shall have the meanings
specified below:


 


1.1                                 “Adverse
Event” shall mean any untoward medical
occurrence in a patient or subject who is administered a Licensed Product,
whether or not considered related to the Licensed Product, including, without
limitation, any undesirable sign (including abnormal laboratory findings of
clinical concern), symptom or disease temporally associated with the use of
such Licensed Product.


 


1.2                                 “Affiliate”
shall mean any corporation or other entity that directly or indirectly
controls, is controlled by or is under common control with a Party to this
Agreement.  A corporation or other
entity shall be regarded as in control of another corporation or entity if it
owns or directly or indirectly controls more than fifty percent (50%) of the
voting stock or other ownership interest of the other corporation or entity, or
if it possesses, directly or indirectly, the power to direct or cause the
direction of the management and policies of the corporation or other entity or
the power to elect or appoint fifty percent (50%) or more of the members of the
governing body of the corporation or other entity.


 


1

















 


1.3                                 “Agreement
Date” shall mean the date first appearing on the first page of this
Agreement


 


1.4                                 “Buy-up
Option” shall have the meaning as set forth in Section 6.1.4.


 


1.5                                 “Clinical
Proof of Concept Study” shall mean a Phase I or Phase II clinical trial
based on a clinical trial protocol to be reviewed by Schering with regard to
safety and efficacy data to be gained, and designated by the Parties prior to
its commencement as a “Clinical Proof of Concept Study.”


 


1.6                                 “Control”
or “Controlled” means (a) with respect to Technology (other than
Proprietary Materials) and/or Patent Rights, the possession by a Party of the
ability to grant a license or sublicense of such Technology and/or Patent
Rights as provided herein without violating the terms of any agreement or
arrangement between such Party and any Third Party and without having to pay
additional amounts to such Third Party in connection with such grant of rights
and (b) with respect to Proprietary Materials, the possession by a Party of the
ability to supply such Proprietary Materials to the other Party as provided
herein without violating the terms of any agreement or arrangement between such
Party and any Third Party and without having to pay additional amounts to such
Third Party in connection with such supply.


 


1.7                                 “Cost”
or “Costs” shall mean expenses incurred by the Parties, determined in a
reasonable manner in accordance with GAAP in case of EPIX and IAS in case of
Schering, and consistent with each Party’s accounting practice.  The Parties recognize that financial records
of Schering are and shall continue to be maintained in accordance with IAS
rather than GAAP.  Schering agrees to
use reasonable commercial efforts to identify for EPIX material differences in
the recognition of expenses under GAAP and IAS and, in cases where there are
material differences, to use the GAAP method of recognition.  Schering shall not be required to produce
financial reports in accordance with GAAP if Schering does not keep such
reports in accordance with GAAP as part of its normal accounting and financial
reporting practices.


 


1.8                                 “Cost
of Goods Sold”  shall mean
the cost for manufacturing the Licensed Product, using Schering’s standard
accounting procedures computed in accordance with IAS applied on a consistent
basis. Such cost shall include, but not be limited to, the fully burdened cost
of all raw materials, auxiliaries and other ingredients, labor and overhead,
depreciation, maintenance and repair, destroyed material, production variance,
imputed interest on safety stocks and capacity cost for dedicated equipment,
for the synthesis, formulation, filling, finishing, labeling, packaging,
storing, testing and quality control, and assurance activities, and shall also
include reasonable expenses for services and transportation charges and any
royalties paid to Third Parties in connection with the manufacturing process or
materials used. “Cost of Goods” shall not include general
and administrative expenses, sales and marketing costs or costs associated with
meeting the chemistry manufacturing and control requirements of the FDA or
other regulatory authorities.


 


1.9                                 “Development
Costs” shall mean all internal (direct and indirect) and Third Party Costs
incurred  by Schering in connection with
the development of Schering Licensed Product 


 


2

















 


following the Exercise
Date.  Such expenses include, but are
not limited to (i) direct labor (salaries, wages, incentive program Costs,
awards and employee benefits but excluding any employee benefits associated with
equity incentive plans); (ii) materials and supplies; (iii) allocated Costs for
building space directly dedicated to the 
development of Schering Licensed Product (including rent, depreciation,
amortization and maintenance) but excluding expenses relating to unused
capacity, development of other products, and amortization of property, plant
and equipment not directly related to the development of Schering Licensed
Product; (iv) Third Party contracts and consulting expenses incurred for
services in connection with the development of Schering Licensed Product; (v)
allocated Costs for information technology directly dedicated to the
development of Schering Licensed Product; (vi) fees, expenses and disbursements
of outside counsel, and payments to Third Parties and internal costs incurred
in connection with the preparation, filing, prosecution and maintenance of
Schering Licensed Patent Rights including the costs of patent interference and
opposition proceedings (“Patent Costs”), and (vii) travel and entertainment, telephone,
recruiting, training (both internal and external), product liability insurance
(including, without limitation, clinical trial insurance), software, personal
computer equipment and support Costs and freight and delivery expenses. Such
Costs shall not include General and Administrative Expenses or expenses
incurred from departments that are not directly engaged in the development of
Schering Licensed Product including, but not limited to, finance and
procurement, corporate administration, human resources, business development
and licensing, sales and marketing except for Costs of investor relations.


 


Development activities for
which Development Costs are incurred include, but are not limited to,
pre-clinical and clinical work and all Costs of the product in development
related to regulatory filings in the Territory.


 


1.10                           “Development
Option” shall have the meaning set forth in Section 4.1 hereof.


 


1.11                           “Effective
Date” shall mean March 1, 2003.


 


1.12                           “EP-2104R”
shall mean EPIX’s proprietary MRI enhancing agent having the chemical structure
illustrated on Exhibit 1.12 attached hereto.


 


1.13                           “EPIX
Licensed Product” shall have the meaning set forth in Section 4.1.2
hereof.


 


1.14                           “EPIX Patent Rights” shall mean all Patent
Rights claiming EPIX Technology, including without limitation the Patent Rights
listed on Exhibit 1.14 attached hereto.


 


1.15                           “EPIX
Royalty Term” shall mean the period commencing on the date of the First
Commercial Sale by EPIX, its Affiliates, or its Sublicensees, of an EPIX
Licensed Product and continuing until the date upon which the total royalties
paid to Schering on Net Sales made anywhere in the Territory, pursuant to
Sections 6.2.1 and 6.2.2 equals [*****] of the Schering Payment paid by
Schering to EPIX during the Proof of Concept Period.


 


3

















 


1.16                           “EPIX
Technology” shall mean all Technology necessary or useful in the Field that
is (a) Controlled by EPIX immediately prior to the Effective Date, or (b)
developed or conceived by EPIX on or after the Effective Date. .


 


1.17                           “Exercise
Date” shall have the meaning set forth in Section 4.1.1 hereof.


 


1.18                           “FDA”
shall mean the United States Food and Drug Administration and any successor
agency thereto.


 


1.19                           “Field”
shall mean thrombus imaging in animals or humans using magnetic resonance.


 


1.20                           “First
Commercial Sale” shall mean the date of the first sale of a Licensed
Product in the ordinary course of business in any country by either Party,
after all required marketing, pricing and reimbursement approvals of the
competent health authority of such country have been obtained by the selling
Party.


 


1.21                           “GAAP”
shall mean United States Generally Accepted Accounting Principles.


 


1.22                           “General
and Administrative Expenses” shall mean all direct and indirect Costs
incurred by Schering or EPIX in connection with departmental units that are not
directly engaged in the Proof of Concept Development Program of the Thrombus
Compound(s).  General and Administrative
Expenses shall include, but not be limited to, charges falling within the
following, groups: finance, procurement, order entry, corporate administration,
legal (both external and internal expenses), human resources, business
development and licensing and investor relations.  General and Administrative Expenses shall exclude the following
groups of charges: clinical trial insurance Costs, facilities and information
technology.


 


1.23                           “IAS”
shall mean the International Accounting Standards.


 


1.24                           “IND”
shall mean an investigational new drug application filed with the FDA and
necessary for beginning clinical trials in humans, or any comparable
application filed with the regulatory authorities of a country other than the
United States prior to beginning clinical trials in humans in such country,
with respect to Licensed Products.


 


1.25                           “Joint
Patent Rights” shall mean all Patent Rights that claim Joint Technology.


 


1.26                           “Joint
Technology” shall mean all Technology or tangible chemical, biological or
physical material invented by employees or agents of either Schering, EPIX or
both in connection with the Proof of Concept Development Program.


 


1.27                           “Licensed
Product” shall mean an EPIX Licensed Product and/or a Schering Licensed
Product as the context indicates.


 


1.28                           “License
Term” shall mean, with respect to each Schering Licensed Product sold by
Schering, its Affiliates, or its Sublicensees, the period commencing with the
First Commercial 


4

















 


Sale of such Schering Licensed
Product and continuing on a country-by-country, and product-by-product basis
until the later of (a) the expiration or termination of the last Valid Claim
covering the Schering Licensed Product, or (b) twelve (12) years from the date
of First Commercial Sale in such country.


 


1.29                           “MAA”
shall mean a marketing approval application filed with the appropriate
regulatory authority in a country other that the United States, after
completion of human clinical trials to obtain marketing approval for a Licensed
Product in such country.


 


1.30                           “MRI”
shall mean magnetic resonance imaging.


 


1.31                           “NDA”
shall mean a new drug application (as defined in Title 21 of the United States
Code of Federal Regulations, as amended from time to time) filed with the FDA
seeking Regulatory Approval to market and sell any Licensed Product in the
United States for a particular indication within the Field.


 


1.32                           “Net
Sales” shall mean  the amount
invoiced by the selling Party, its Affiliates or Sublicensees for sales of a
Licensed Product to unaffiliated Third Parties less the following deductions
applicable to the Licensed Product for:


 


(ii)                                  transportation
charges and insurance charges paid by the selling Party;


 


(iii)                               sales
and excise taxes or customs duties paid by the selling Party or any other
governmental charges imposed upon the sale of the Licensed Product and paid by
the selling Party exclusive of taxes on the income of the selling Party;


 


(iv)                              fees
paid to distributors, consignees or agents in connection with the sale of the
Licensed Product;


 


(v)                                 rebates
and premiums granted in connection with the sale of a Licensed Product;


 


(vi)                              credits
to customers on account of governmental requirements, price differences,
rejection, outdating, returns or recalls of the Licensed Product;


 


(vii)                           quantity
discounts, cash discounts or chargebacks granted in connection with the sale of
the Licensed Product;


 


(viii)                        provisions
for price reductions and;


 


(ix)                                a
selling Party’s standard allowance for bad debts as demonstrated to the other
Party’s reasonable satisfaction, and in no case in excess of [*****]


 


For the purpose of calculating Net Sales, the Parties recognize that
(a) the selling Party’s customers may include persons in the chain of commerce
who enter into agreements with the 


 


5

















 


selling Party
as to price even though title to the Licensed Product does not pass directly
from the selling Party to such customers and even though payment for such
Licensed Product is not made by such customers directly to the selling Party
and (b) in such cases, chargebacks paid by the selling Party to or through a
Third Party (such as a wholesaler) can be deducted by the selling Party from
gross revenue in order to calculate Net Sales. Any deductions above, which
involve a payment by the selling Party, shall be taken as a deduction against
aggregate sales for the period in which the payment or deduction is made.


 


In the event a Licensed Product is sold in the form of a combination
product containing one or more active ingredients in addition to a Licensed
Product, Net Sales for such combination product will be adjusted by multiplying
actual Net Sales of such combination product by the fraction A / (A+B) where A
is the invoice price of the Licensed Product, if sold separately, and B is the
invoice price of any other active ingredient or ingredients in the combination,
if sold separately.  If, on a
country-by-country basis, the other active ingredient or ingredients in the
combination are not sold separately in that country, Net Sales shall be
calculated by multiplying actual Net Sales of such combination product by the
fraction A / C where A is the invoice price of the Licensed Product if sold
separately, and C is the invoice price of the combination product.  If, on a country by country basis, neither
the Licensed Product nor the other active component or components of the
combination product is sold separately in said country, Net Sales shall be
determined between the Parties in good faith.


 


1.33                           “Part or Parts of the Agreement” means either all terms relating
to the Proof of Concept Development Program or all terms relating to a license
granted or optioned under this Agreement, depending on which terms are
involved.


 


1.34                           “Party”
shall mean EPIX or Schering.


 


1.35                           “Patent
Rights” shall mean all rights and interests in and to issued patents and
pending patent applications, which for purposes of this Agreement shall be
deemed to include certificates of invention and applications for certificates
of invention and priority rights, in any country, including all provisional
applications, substitutions, continuations, continuations-in-part, divisionals,
and renewals, all letters patent granted thereon, and all reissues,
reexaminations and extensions thereof.


 


1.36                           “Proof
of Concept Development Program” shall mean the early development program up
to the completion of the Clinical Proof of Concept Study described generally in
the Proof of Concept Plan.


 


1.37                           “Proof
of Concept Period” shall mean the period of time commencing on the start of
a Proof of Concept Development Program for a Thrombus Compound, and ending upon
delivery to Schering by EPIX of the Final Report for such Program pursuant to
Section 4.1.1 hereof. The Proof of Concept Period for EP-2104R shall commence
on the Effective Date.


 


1.38                           “Proof
of Concept Plan” shall have the meaning set forth in Section 2.3
hereof.


 


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1.39                           “Proprietary
Materials” means any tangible chemical, biological or physical research
materials that are furnished by or on behalf of one Party to the other Party in
connection with this Agreement, regardless of whether such materials are
specifically designated as proprietary by the transferring Party.


 


1.40                           “Schering
Licensed Product” shall have the meaning set forth in Section 5.1.2
hereof.


 


1.41                           “Schering
Option Product” shall have the meaning set forth in Section 4.1.


 


1.42                           “Schering Patent Rights” shall mean all
Patent Rights claiming Schering Technology, including without limitation the
Patent Rights listed on Exhibit 1.42 attached hereto.


 


1.43                           “Schering
Payment” shall have the meaning set forth in Section 3.1 hereof.


 


1.44                           “Schering
Technology” shall mean all Technology necessary or useful in the Field that
is (a) Controlled by Schering immediately prior to the Effective Date, or (b)
developed or conceived by Schering on or after the Effective Date.


 


1.45                           “Sublicense
Income” means all payments received by EPIX from a sublicensee in
connection with the grant of a sublicense under a development and a commercial
license of right under Section 12.4, including without limitation, royalties,
up-fronts, technology access fees, milestones and fifty percent (50%) of the
premium over fair market value paid to EPIX 
in connection with  the issuance
of securities of EPIX where fair market value is based on the number of
securities issued multiplied by the average closing price of the stock as
quoted on NASDAQ, such average based on a twenty (20) business day period, but
excluding (a) payments made to support or fund research and development
activities and (c) payments made for other rights or tangible property to the
extent not in excess of the fair market value of such other rights or tangible
property.


 


1.46                           “Sublicensee”
shall mean any Third Party to whom either Schering or EPIX sublicenses all or some
of the license rights grant to it hereunder pursuant to the terms of Section
6.1.3 hereof.


 


1.47                           “Technology”
shall mean and include all present and future inventions, trade secrets,
copyrights, know-how, data, regulatory submissions and other intellectual
property rights of any kind Controlled by a Party, including Proprietary
Materials.


 


1.48                           “Term”
shall have the meaning set forth in Section 12.1 hereof.


 


1.49                           “Territory”
shall mean worldwide.


 


1.50                           “Third
Party” shall mean any entity other than EPIX or Schering or their
respective Affiliates.


 


7

















 


1.51                           “Thrombus
Compound(s)” shall have the meaning set forth in Section 2.1 hereof.


 


1.52                           “Valid
Claim” shall mean a claim of an issued patent or a pending patent
application within the Patent Rights that has not expired or been cancelled,
revoked or held invalid by a final decision of a court or other authority
having valid jurisdiction, from which no further appeal can be taken or from
which the time for appeal has expired.


 


ARTICLE 2:  THE PROOF OF CONCEPT DEVELOPMENT
PROGRAM


 


2.1.                              General.  EPIX
and Schering wish to establish a collaborative alliance to develop specific
compound candidates in the Field (the “Thrombus Compound(s)”).  The collaboration will consist of a Proof of
Concept Development Program for the Thrombus Compound(s) the completion of
which will trigger certain options for both Parties regarding further
development and the commercialization of such Thrombus Compound(s).   The initial Proof of Concept Development
Program shall be established for the Thrombus Compound EP-2104R. Further
Thrombus Compound(s) shall only be developed upon agreement by the Parties. The
collaboration will consist of the provision of data by EPIX to Schering, which
allow the assessment of the clinical and commercial utility of the Thrombus
Compound by Schering. For this purpose EPIX shall design, perform and manage a
Proof of Concept Development Program for the Thrombus Compound(s) with the goal
to provide Schering with the defined clinical data in volunteers and patients
as defined in Exhibit 2.1 (hereinafter “the Deliverables”). Generated
preclinical and chemical data will be disclosed to Schering as well. For the
sake of clarity, the Parties agree that the work performed by EPIX under the
Proof of Concept Plan is not subject to prior consent by Schering, except as
explicitly provided in this Agreement.


 


2.2.                              Conduct of the Proof of Concept
Development Program.  The
Proof of Concept Development Program shall consist generally of chemical and
pre-clinical development work necessary to support the proper conduct of the
Clinical Proof of Concept Study in healthy volunteers and patients according to
the applicable international regulations and quality standards (i.e. ICH GCP,
GLP etc.) and the applicable national laws and regulations. The goal of the
Proof of Concept Development Program is the provision of the Deliverables.
Schering will be informed regularly on the timely progress of the program and
on relevant safety and efficacy influencing findings.


 


2.3.                              Proof of Concept Plan.  EPIX is responsible to develop a plan
reasonably describing the work to be conducted by EPIX related to EP-2104R
including a clinical trial protocol (hereinafter “Proof of Concept Plan”) to
fulfill the objectives of this Agreement. The Proof of Concept Plan shall be
made available to Schering for information. It is not subject to consent by
Schering; provided, however, that the clinical trial protocol which is part of
the Proof of Concept Plan shall be subject to review by Schering with regard to
safety and efficacy data to be gained to assure that the objectives of this
Agreement with regard to the Deliverables can be achieved.


 


8

















 


2.4.                              Development Information.  In the course of its performance of the
Proof of Concept Development Program, EPIX shall keep Schering reasonably
informed as to its progress under each Proof of Concept Plan.


 


2.5.                              Availability to Employees.  Schering hereby agrees to make its employees
and non-employee consultants reasonably available, at no cost to EPIX, to
consult with EPIX on matters relating to the development of the Thrombus
Compound(s), including scientific and technical issues arising during the Proof
of Concept Development Program; provided, however, that such advice is not
binding to EPIX and does not affect EPIX’ responsibilities under this
Agreement.


 


ARTICLE 3:  PROOF OF CONCEPT DEVELOPMENT PROGRAM
FUNDING


 


3.1.                              Funding Commitment.  In consideration of the work performed by
EPIX under the Proof of Concept Plan, Schering shall pay to EPIX  an overall amount of US$ 8,972,707 (Eight
Million Nine Hundred and Seventy Two Thousand Seven Hundred and Seven Dollars)
consisting of US$ [*****] for the clinical work and US$ [*****] for the
chemical and pre-clinical work (hereinafter “the Schering Payment”) based on
EPIX’ budget plan attached hereto as Exhibit 3.1. Costs incurred by EPIX in the
course of its performance under the Proof of Concept Plan, in excess of the
Schering Payment, will be the responsibility of EPIX. In case that EPIX’ actual
Costs in the course of its performance under the Proof of Concept Plan are
lower than the Schering Payment, EPIX has no obligation to pay the Schering
Payment back.


 


3.2.                              Funding
Payments.  The Schering Payment
shall be paid to EPIX as follows:


 


(a)                                  US$
[*****] shall be paid to EPIX within ten (10) business days of the date
appearing in the first paragraph of this Agreement; and


 


(b)                                 US$
[*****] shall be paid to EPIX in such installments as indicated below, not less
than five (5) business days prior to the start of calendar quarter indicated
below:


 


	
  Calendar Quarter

  	
   

  	
  Amount to be paid to EPIX (US$)

  
	
  Third quarter of 2003

  	
   

  	
  [*****]

  
	
  Fourth quarter of 2003

  	
   

  	
  [*****]

  
	
  First quarter of 2004

  	
   

  	
  [*****]

  
	
  Second quarter of 2004

  	
   

  	
  [*****]

  
	
  Third quarter of 2004

  	
   

  	
  [*****]

  
	
  Fourth quarter of 2004

  	
   

  	
  [*****]

  
	
  First quarter of 2005

  	
   

  	
  [*****]

  



 


9

















 


ARTICLE 4:  LICENSE OPTION


 


4.1.                              Schering’s Development Option.  Subject to the terms and conditions set
forth herein, EPIX hereby grants to Schering the exclusive right and
option  (the “Development Option”) to
acquire a license as provided under Section 5.1.2. hereof to further develop
and commercialize products based upon, derived from or incorporating a Thrombus
Compound(s), after completion of the Clinical Proof of Concept Study for such
Thrombus Compound(s) (each a “Schering Option Product”).


 


4.1.1.                     Commencement
of Option Period and Exercise.  Upon
completion of the Clinical Proof of Concept Study, EPIX shall prepare, and
deliver to Schering, a final study report containing the Deliverables in order
to enable Schering to evaluate the data for its Option purposes (the “Final
Report”).  Schering shall exercise the
Development Option, if at all, by delivering to EPIX within ninety (90) days of
delivery by EPIX of the Final Report (the “Option Period”): (i) a written
notice to EPIX of its desire to exercise the Development Option and (ii)
payment of the Upfront License Fee described in Section 6.1.1 hereof (the
date upon which EPIX receives such notice and payment is, the “Exercise Date”).


 


4.1.2.                     EPIX
Licensed Product.  If Schering
declines or fails to exercise the Development Option on or before expiration of
the Option Period (the “EPIX License Date”), the Development Option shall
immediately terminate and  EPIX shall
have the sole right, but not the obligation, under the license granted pursuant
to Section 5.1.1 hereof to further develop and commercialize such Schering
Option Product (thereafter, an “EPIX Licensed Product”). Such right and license
of EPIX shall survive termination of this Agreement by (i) Schering, pursuant
to Section 12.2 hereof and (ii) EPIX, pursuant to Section 12.3 hereof.


 


ARTICLE 5:  LICENSES


 


5.1.                              License Grants.


 


5.1.1.                     EPIX
License.  Schering hereby grants to
EPIX (i) a non-exclusive, fully paid-up, royalty-free, worldwide license in the
Field under the Schering Patent Rights and Schering Technology, and Schering’s
interests in the Joint Patent Rights and Joint Technology, for the sole purpose
of conducting the activities required in the performance of EPIX’s obligations
under the Proof of Concept Development Program, and (ii), subject to Schering’s
failure to exercise the Development Option as set forth in Section 4.1 hereof
or in the event EPIX terminates this Agreement pursuant to the terms of Section
12.3.2 hereof, a non-exclusive, worldwide license under the Schering Patent
Rights and the Schering Technology, to the extent required, and an exclusive,
royalty-bearing license under Schering’s interests in the Joint Patent Rights
and Joint Technology, each with the right to grant sublicenses solely as
provided under Section 5.1.3 below, to permit EPIX to develop, have
developed, make, have made, use, have used, sell, offer for sale, have sold,
import, and have imported EPIX Licensed Products in the Territory, for any and
all uses within the Field.


 


10

















 


5.1.2.                     Schering
License.  Effective as of the Exercise
Date and subject to the terms and conditions herein, EPIX grants to Schering
(i) a non-exclusive worldwide license under the EPIX Patent Rights and EPIX
Technology, to the extent required, and (ii) an exclusive, worldwide,
royalty-bearing license under EPIX’s interests in the Joint Patent Rights and
Joint Technology, each with the right to grant sublicenses solely as provided
under Section 5.1.3 below, to permit Schering, to develop, have developed,
to make, have made, use, have used, sell, offer for sale, have sold, import,
and have imported Schering Option Products (each, thereafter, a “Schering
Licensed Product”) in the Territory during the License Term, for any and all
uses within the Field.


 


5.1.3.                     Sublicensing.  Each Party shall have the right to extend
the rights and licenses granted to it under Section 5.1.1 or
Section 5.1.2, as applicable, to its Affiliates and Third Parties; provided,
that, it shall be a condition of any such extension or sublicense that
the Sublicensees agree to be bound by all of the applicable terms and
conditions of this Agreement.  Each
Party granting such rights shall provide copies (redacted as to the financial
terms) to the other Party of each extension or sublicense to be granted to any
Affiliate or Third Parties under this Section within ten (10) business days
after such execution.


 


5.2.                              Retained Rights.  Each Party reserves the right to practice all Technology and all
Patent Rights that it Controls to the extent not expressly subject to a right,
license or option hereunder.  No rights
are granted hereunder by implication or estoppel.


 


5.3.                              Diligence. 
Schering will exercise commercially reasonable, continuous efforts and
diligence in developing and commercializing Schering Licensed Products and in
undertaking investigations and actions required to obtain Regulatory Approvals
necessary to market Schering Licensed Products in the Field in the Territory,
such diligence to be no less than the efforts and resources Schering would use
for a product candidate owned by it or to which it has rights, which is of
similar market potential as the applicable Schering Licensed Product.  Failure
of Schering to comply with the terms of this Section 5.3 shall constitute
a Default under Section 12.3 hereof and shall be subject to the terms of
Section 12.3.2 hereof.


 


5.4.                              Labeling and Packaging.   If EPIX has exercised its Buy-up Option
pursuant to the terms of Section 6.1.4 hereof to the maximum percentage
provided thereunder for a Schering Licensed Product, the labeling and packaging
for such Schering Licensed Products shall bear EPIX’s name and logo, in a form
to be mutually agreed upon by the Parties, in addition to Schering’s name,
trademark (to be selected by Schering in its sole discretion), and trade dress
and subject to applicable laws and regulations.


 


5.5.                              Reports and Forecasts.


 


5.5.1.  Reports.  Commencing
on the date that is three months following the Exercise Date Schering shall
provide EPIX, no less frequently than annually, with brief written reports
summarizing Schering’s  efforts to
develop and commercialize Schering Licensed Products hereunder.


 


11

















 


5.5.2.                     Notification
of Events.  In addition, Schering
shall provide EPIX with prompt written notice of the occurrence of the First Commercial
Sale of any Schering Licensed Product in any country and agrees to provide EPIX with Adverse Event information and product
complaint information relating to Schering Licensed Products as compiled and prepared by Schering in the normal course of business in connection
with the development, commercialization or sale of any Schering Licensed Product, within time frames consistent with reporting obligations under
applicable laws and regulations.  All
reports, updates, Adverse Event, product complaint, forecasts and other
information provided by one Party to the other Party under this Agreement
(including under this Section 5.4), shall be considered Confidential
Information of the disclosing Party, subject to the terms of Article 9.


 


ARTICLE 6:  LICENSE PAYMENTS


 


6.1.                              Schering License Terms.


 


6.1.1.                     Up-Front
Licensing Fee.  In consideration of
the grant of the license to Schering by EPIX as described in
Section 5.1.2. hereof, upon the Exercise Date, Schering shall pay to EPIX
an upfront license fee (the “Upfront License Fee”) equal to the sum of [*****]
($[*****]) U.S. dollars. The Upfront License Fee shall be nonrefundable and
noncreditable.


 


6.1.2.                     Milestone
Payments.  In further consideration
of the grant of the license to Schering by EPIX as described in
Section 5.1.2 and subject to the other terms and conditions of this
Agreement, Schering shall make the following nonrefundable, noncreditable
payments in United States dollars to EPIX within thirty (30) days of the first
occurrence of each of the following events by Schering, its Affiliates or
Sublicensees:


 


	
  Milestone

  	
   

  	
  Payment

  
	
   

  	
   

  	
   

  
	
  [*****]

  	
   

  	
  $

  	
  [*****]

  
	
  [*****]

  	
   

  	
  $

  	
  [*****]

  
	
  [*****]

  	
   

  	
  $

  	
  [*****]

  



 


It is hereby
acknowledged and agreed that any milestone payment shall be made only once,
with respect to the first achievement of the relevant milestone for the first
Schering Licensed Product, regardless of how many times such milestones are
achieved by Schering Licensed Products and regardless of how many times a
particular Schering Licensed Product achieves such milestones.


 


6.1.3.                     Royalties.  In further consideration of the grant of the
license to Schering by EPIX as described in Section 5.1.2. hereof, subject
to reduction as set forth in Section 6.1.6 below Schering shall pay EPIX a
royalty based on total annual Net Sales of each Schering 


 


12

















 


Licensed Product sold by
Schering, its Affiliates and Sublicensees during the License Term, at the
following rates:


 


	
  For Annual Net Sales of a Schering Licensed Product:

  	
   

  	
  Royalty Rate (%)

  
	
   

  	
   

  	
   

  
	
  Above $[*****]and up to $[*****]

  	
   

  	
  [*****]

  
	
  Above $[*****]

  	
   

  	
  [*****]

  



 


6.1.4.                     Buy-up
Option for EPIX.  In addition to the
royalties to be paid under Section 6.1.3 above EPIX shall have the option (the
“Buy-up Option”) of increasing such royalty rates payable with respect to each
Schering Licensed Product by reimbursing Schering for a percentage of all
Development Costs incurred by Schering since the Exercise Date as follows.  For every [*****] of the total Development
Costs incurred by Schering following the Exercise Date for a particular
Schering Option Product that EPIX reimburses Schering for, the royalty rate
otherwise payable under the table above will be increased by [*****].  This option is limited such that EPIX cannot
reimburse Schering for more than [*****] [*****] of such Development Costs
incurred by Schering for any Schering Licensed Product and so the maximum
royalty rates payable for any Schering Licensed Product are [*****] [*****];
provided, however, if the aggregate Cost of Goods Sold and any royalties
payable hereunder and to third parties ([*****]) for any Schering Licensed
Product is [*****] than [*****] of the [*****] of [*****], then [*****] this
[*****] hereunder.  EPIX must exercise
this option with respect to a Schering Licensed Product by providing written
notice to Schering within [*****] of the Exercise Date.


 


6.1.5.                     Payments
of EPIX under Buy-up Option.  Within
ten (10) business days from the end of the calendar quarter in which EPIX has
exercised its Buy-up Option and on a quarterly basis thereafter, EPIX shall pay
its share of the Development Costs incurred by Schering during the relevant
calendar quarter except that the first such payment shall include reimbursement
based on total Development Costs incurred by Schering from the date it
exercised the Schering Option. The Development Costs incurred by Schering
during each calendar quarter shall be converted from EURO into United States
Dollars by the EURO Foreign Exchange Reference Rate published by the European Central
Bank in Frankfurt/Main on the last day of the applicable calendar quarter. The
corresponding calculation will be provided by Schering to EPIX within fifteen15
business days from the end of the respective calendar quarter.


 


6.1.6.                     Royalty
Reduction.  The Parties hereby
acknowledge that royalties may be payable hereunder for a Schering Licensed
Product that is not covered by any claim in patent rights subject to a license
granted hereunder.  Under such
circumstances, royalties shall be payable as set forth herein, but at a reduced
rate equal to fifty percent (50%) of the royalty rate which would otherwise be
payable hereunder, if the manufacture, use, sale or importation of such
Schering Licensed Product were covered by a claim in patent rights subject to a
license granted hereunder.  Such reduced
royalties shall be in consideration of: (i) the commercial advantage and
background information gained from the Proof of Concept Development Program, 


 


13

















 


(ii) the contribution of the unpatented
Technology to the successful development of the Schering Licensed Product and
(iii) the exclusivity of the collaboration.


 


6.2.                              EPIX License Terms.


 


6.2.1.                     Royalties.  In consideration of the grant of the
licenses to EPIX by Schering as described in Section 5.1.1(ii) hereof,
subject to reduction as set forth in Section 6.2.3 below, EPIX shall pay
Schering a royalty equal to [*****] percent of Net Sales of each EPIX Licensed
Product sold by EPIX and/or its Affiliates and/or Sublicensees during the EPIX
Royalty Term. Upon expiration of the EPIX Royalty Term, EPIX shall have a fully
paid-up, non-exclusive, irrevocable, freely transferable and sublicensable
license in the Territory under the Schering Patent Rights, Schering Technology,
and Joint Patent Rights and Joint Technology to develop, have developed, make,
have made, use, have used, sell, have sold, offer for sale, import and have
imported EPIX Licensed Products in the Territory.


 


6.2.2.                     Royalty
Reduction.  The Parties hereby
acknowledge that royalties may be payable hereunder for an EPIX Licensed
Product that is not covered by any claim in patent rights subject to a license
granted hereunder.  Under such
circumstances, royalties shall be payable as set forth herein, but at a reduced
rate equal to fifty percent (50%) of the royalty rate which would otherwise be
payable hereunder, if the manufacture, use, sale or importation of such EPIX
Licensed Product were covered by a claim in patent rights subject to a license
granted hereunder.  Such reduced royalty
payments shall be in consideration of: (i) the commercial advantage and
background information gained from the Proof of Concept Development Program,
(ii) the contribution of the unpatented Technology to the successful development
of the EPIX Licensed Product and (iii) the exclusivity of the collaboration.


 


ARTICLE 7:  GENERAL PAYMENT TERMS


 


7.1.                              Payment Dates and Reports.  All royalty payments on Net Sales shall be
paid within sixty (60) days after the end of each calendar quarter in which
such Net Sales are made and shall be accompanied by a report for the applicable
calendar quarter showing the Net Sales of each Licensed Product sold, in each
country, the applicable royalty rate for such Licensed Product, and a
calculation of the amount of royalty due.


 


7.2.                              Payments; Currency Conversion.


 


7.2.1.                     Payments.  Payments by either Party to the other Party
under this Agreement shall be made in United States dollars by wire transfer of
immediately available funds to an account at a commercial bank designated by
the receiving Party at least ten (10) business days before such payment is due.


 


7.2.2.                     Royalty
Payments within Schering.  The
calculation of royalty payments within Schering is based on EURO. Therefore,
where payments are based on Net Sales in countries other than the member states
of the European Monetary Union, the amount of such Net Sales expressed in the
currency of each country shall be converted into EURO at the EURO 


 


14

















 


Foreign Exchange Reference Rates published by
the European Central Bank in Frankfurt / Main, Germany on the last business day
of the applicable calendar quarter. The resulting EURO amount will be converted
into United States dollars again at the EURO Foreign Exchange Reference Rates
published by the European Central Bank in Frankfurt / Main, Germany on the last
business day of the applicable calendar quarter. These EURO Foreign Exchange
Reference Rates are, as of the effective date, published on Reuters screen
<ECB37>. If no EURO Foreign Exchange Reference Rate is determined for the
relevant currency the parties shall agree upon another reference rate.


 


7.2.3.                     Royalty
Payments within EPIX.  The
calculation of royalty payments within EPIX is based on United States dollars.
Therefore, where payments are based on Net Sales in countries other than the
United States, the amount of such Net Sales expressed in the currency of each
country shall be converted into United States dollars at the EURO Foreign
Exchange Reference Rates published by the European Central Bank in Frankfurt /
Main, Germany  on the last Business
Day of the applicable calendar quarter. If no EURO Foreign Exchange Reference
Rate  is determined for the
relevant currency the parties shall agree upon another reference rate.


 


7.3.                              Records; Audit Rights; Disputes.


 


7.3.1.                     Records of
Revenues and Expenses; Audit Rights. 
Each Party will maintain complete and accurate records which are
relevant to the determination of Development Costs, milestone payments and
royalty payments under this Agreement and such records shall be open during
reasonable business hours for a period of two (2) years from creation of
individual records for examination at the other Party’s expense and not more
often than once each calendar year by a certified public accountant selected by
the other Party (subject to the consent of the Party to be audited, such
consent not to be unreasonably withheld or delayed), or the other Party’s
internal accountants (unless the Party to be audited objects to the use of such
internal accountants) for the sole purpose of verifying for the inspecting
Party the correctness of calculations and classifications of such Development
Costs, milestone payments and royalty payments under this Agreement. Each Party
shall bear its own Costs related to such audit; provided, that, for any
underpayments greater than [*****] of annual Development Costs, milestone
payments and/or royalty payments by the audited Party, the audited Party shall
pay the other Party the amount of underpayment, together with interest as
provided in Section 7.3.3 below, from the time the amount was due and the
inspecting Party’s out-of-pocket expenses related to the audit.  For any underpayments less than [*****] of
annual Development Costs and/or royalty payments (as the case may be), found
under this Section, the audited Party shall pay the inspecting Party the amount
of the underpayment.  Any overpayments
by the audited Party will be refunded to the audited Party or credited to
future payments by the audited Party to the inspecting Party, at the audited
Party’s election.  Any records or
accounting information received from the audited Party shall be Information of
the audited Party for purposes of Article 9. 
Results of any such audit shall be provided to both Parties, and shall
be Information of the audited Party for purposes of Article 9.


 


15

















 


7.3.2.                     Resolutions
of Payment Disputes.  Except as set
forth in this Section, the provisions of Section 13.6 shall not be
applicable to disputes described in this Section.  If there is a dispute between the Parties following any audit
performed pursuant to this Section 7.3 (an “Audit Disagreement”) (i)
within thirty (30) business days of the identification of an Audit Dispute and
notice thereof to the other Party, the Parties shall jointly select a
recognized international accounting firm to act as an independent expert to
resolve such Audit Disagreement; (ii) the Audit Disagreement submitted for
resolution shall be described by the Parties to the independent expert, which
description may be in written or oral form, within ten (10) business days of
the selection of such independent expert; (iii) the independent expert shall
render a decision on the matter as soon as practicable; (iv) the decision of
the independent expert shall be final and binding unless such Audit
Disagreement involves alleged fraud, breach of this Agreement or construction
or interpretation of any of the terms and conditions thereof, which Audit
Disagreements shall be resolved as set forth in Section 13.6; and (v) all
fees and expenses of the independent expert, including any Third Party support
staff or other costs incurred with respect to carrying out the procedures
specified at the direction of the independent expert in connection with such
Audit Disagreement, shall be borne by each Party in inverse proportion to the
disputed amounts awarded to such Party by the independent expert through such
decision (e.g., EPIX disputes $100; the independent expert awards EPIX $60;
EPIX pays for forty percent (40%) of the independent expert’s costs, and
Schering pays for sixty percent (60%) of the independent expert’s costs.)


 


7.3.3.                     Payments;
Interest.  Any payments due under
this Agreement shall be due on such date as specified in the Agreement and, in
the event such date is not a business day, then the next succeeding business
day.  Any failure by a Party to make a
payment within ten (10) days after the date when due shall obligate such Party
to pay computed interest, the interest period commencing on the due date and
ending on the payment day, to the receiving Party at a rate per annum
[*****].  The interest shall be computed
on the basis of a 365/360 year; interest shall be compounded annually in arrears.  Such interest shall be due and payable on
the tender of the underlying principle payment.


 


7.3.4.                     Financial
Procedures.  Each Party shall
include in any agreement with its Affiliates or Sublicensees terms requiring
such party to retain records as required in this Section 8.3 and to permit
the such Party to inspect such records as required by this Section 7.3.


 


7.4.                              Withholding Taxes.  Each Party shall pay any and all taxes levied on account of
signing fees, research and development funding, milestone payments, royalties
or other payments received from the other Party under this Agreement. If laws
or regulations require that taxes be withheld by the paying Party on any such
payments, the paying Party shall: (i) deduct those taxes from the remittable
payment; (ii) timely pay the deducted taxes to the proper taxing authority; and
(iii) send proof of payment to the receiving Party within thirty (30) days of
receipt of confirmation of payment from the relevant taxing authority.


 


16

















 


ARTICLE 8:  INTELLECTUAL PROPERTY


 


8.1.                              Inventorship. 
Inventorship of any and all inventions or discoveries conceived and/or
first reduced to practice under the Proof of Concept Development Program or
within six (6) months of termination of the Proof of Concept Development
Program will be determined in accordance with the applicable patent laws.


 


8.2.                              Ownership.


 


8.2.1.                     EPIX
Intellectual Property Rights.  As
between the Parties, EPIX shall have sole and exclusive ownership of all right,
title and interest on a worldwide basis in and to any and all EPIX Technology
and EPIX Patent Rights, with full rights to license or sublicense, subject to
the rights granted to Schering as set forth herein.  Without limiting the foregoing, EPIX shall solely Control all
Patent Rights, all trade secret rights, all know-how and any other intellectual
property rights in the EPIX Technology, including the sole and exclusive right
to exclude others from making, using, selling, offering for sale or importing the
EPIX Technology or any products that consist of, incorporate or are derived
from any EPIX Technology.


 


8.2.2.                     Schering
Intellectual Property Rights.  As
between the Parties, Schering shall have sole and exclusive ownership of all
right, title and interest on a worldwide basis in and to any and all Schering
Technology and Schering Patent Rights, with full rights to license or
sublicense, subject to the rights granted to EPIX as set forth herein.  Without limiting the foregoing, Schering
shall solely Control all Patent Rights, all trade secret rights, all know-how
and any other intellectual property rights in the Schering Technology including
the sole and exclusive right to exclude others from making, using, selling,
offering for sale or importing the Schering Technology or any products that
consist of, incorporate or are derived from any Schering Technology.


 


8.2.3.                     Joint
Intellectual Property Rights.  The
Parties shall jointly own all Joint Technology and Joint Patent Rights, subject
to the rights of, and the licenses granted to, each Party herein.


 


8.3.                              Filing, Prosecution, Maintenance,
Enforcement and Defense.


 


8.3.1.                     Filing,
Prosecution, Maintenance, Enforcement and Defense of EPIX Patent Rights and
Joint Patent Rights.  During the
Proof of Concept Period and License Term, subject to Dyax Corp.’s rights under
that certain Collaboration Agreement between Dyax Corp. and EPIX dated June 20,
1997, as amended (the “Dyax Agreement”), EPIX shall be solely responsible for
the filing, prosecution and maintenance of the EPIX Patent Rights and Joint
Patent Rights, keeping Schering reasonably informed thereof, and enforcement
and defense of the EPIX Patent Rights during the Proof of Concept Period and
License Term shall be conducted in accordance with this Section 8.3. With
regard to any application for Joint Patent Rights, EPIX shall inform Schering
at least ninety (90) days before the end of the priority year for such
application in which countries EPIX intends to file. The same information
obligation shall apply for any transfer of PCT or EP applications or patents to
national stages. Patent Costs for Joint 


 


17

















 


Patent Rights shall be paid by EPIX subject
to reimbursement by Schering up to a maximum annual sum of [*****] dollars
($[*****]), payable upon receipt of quarterly invoices.


 


(a)                                  Abandonment;
Failure to Pay.  Subject to the
terms of the Dyax Agreement, if EPIX fails to undertake (i) any filing of any
patent application or submission, (ii) making any payment, or (iii) any other
action necessary to obtain or maintain a patent under the EPIX Patent Rights or
Joint Patent Rights, then following written notice of such intention, which
notice shall be provided by EPIX to Schering, if at all, not less than ninety
(90) days prior to the last date for making the applicable filing, submission
or payment to preserve rights under such patent or patent application, Schering
may undertake such filing, submission or payment, at its own expense, in EPIX’s
name.


 


(b)                                 Infringement
by Others.  EPIX and Schering shall
each promptly notify the other in writing of any alleged or threatened
infringement in the Field of any EPIX Licensed Patent Rights, or Joint Patent
Rights, of which they become aware. 
Between the Parties, EPIX shall have the first right (but not the
obligation), at its own expense and with legal counsel of its own choice, to
bring suit (or take other appropriate legal action) against any actual, alleged
or threatened infringement of the EPIX Patent Rights in the Field.  Schering shall have the right, at its own
expense, to be represented in any such action by EPIX by counsel of Schering’s
own choice; provided, however, that under no circumstances shall
the foregoing affect the right of EPIX to control the suit as described
above.  Subject to the terms of the Dyax
Agreement, if EPIX does not file any action or proceeding against any such
infringement within six (6) months after the later of (i) EPIX’s notice to
Schering under this Section 8.3.1, (ii) Schering’s notice to EPIX
under this Section 8.3.1, or (iii) a written request from Schering to
take action with respect to such infringement, then Schering shall have the
right (but not the obligation), at its own expense, to bring suit (or take
other appropriate legal action) against such actual, alleged or threatened
infringement, with legal counsel of its own choice, but shall not be permitted
to settle any such suit without the prior consent of EPIX, which consent shall
not be unreasonably withheld.  With
regard to Joint Patent Rights the above mechanisms shall apply accordingly; provided,
however, that Schering shall have the first right (but not the
obligation) to bring suit.


 


(c)                                  Monetary
Awards.  Any damages, monetary
awards or other amounts recovered, whether by judgment or settlement, pursuant
to any suit, proceeding or other legal action taken under this Section, shall
applied as follows:


 


(i)                                     First,
to reimburse the Parties for their respective costs and expenses (including
reasonable attorneys’ fees and costs) incurred in prosecuting such enforcement
action;


 


(ii)                                  Second,
to Schering in reimbursement for lost sales (net of royalties) associated with
Schering Licensed Products and to EPIX in reimbursement for lost royalties
owing hereunder based on such lost sales;


 


18

















 


(iii)                               Third,
any amounts remaining shall be allocated as follows:  (a) if EPIX is the Party bringing such suit or proceeding or
taking such other legal action, one hundred percent (100%) to EPIX, (b) if
Schering is the Party bringing such suit or proceeding or taking such other
legal action, one hundred percent (100%) to Schering, and (c) if the suit is
brought jointly, fifty percent (50%) to each Party.


 


8.3.2.                     Declaratory
Actions.  In the event that a declaratory
judgment action alleging invalidity or non-infringement in the Field of any of
the EPIX Patent Rights, or Joint Patent Rights, in the Territory shall be
brought against either Party, the Party against which such action is brought
shall promptly notify the other Party in writing.  The Party against which such action is brought will defend said
action using counsel selected by it and in the case of an action against
Schering, approved by EPIX, such approval not to be unreasonably withheld or
delayed.  Schering may not enter into
any settlement, consent judgment or other voluntary final disposition of the
action without the consent of EPIX, such consent not to be unreasonably
withheld or delayed.  The Costs of any
defense under this Section 8.3.2 will be the responsibility of the
defending Party.


 


8.3.3.                     Filing,
Prosecution, Maintenance, Enforcement and Defense of Schering Patent Rights.  During the Term of this Agreement, Schering
shall be solely responsible, at its own expense for the filing, prosecution and
maintenance of the Schering Licensed Patent Rights, keeping EPIX reasonably
informed thereof and enforcement and defense of the Schering Licensed Patent
Rights during the Proof of Concept Period and EPIX Royalty Term shall be
conducted in accordance with this Section 8.3.


 


(a)                                  Abandonment;
Failure to Pay.  If Schering fails
to undertake (i) any filing of any patent application or submission, (ii)
making any payment, or (iii) any other action necessary to obtain or maintain a
patent under the Schering Patent Rights then following written notice of such
intention, which notice shall be provided by Schering to EPIX, if at all, not
less than ninety (90) days prior to the last date for making the applicable
filing, submission or payment to preserve rights under such patent or patent
application, EPIX may undertake such filing, submission or payment, at its own
expense, in Schering’s name.


 


(b)                                 Infringement
by Others.  EPIX and Schering shall
each promptly notify the other in writing of any alleged or threatened
infringement in the Field of any Schering 
Patent Rights of which they become aware.  Schering shall have the first right (but not the obligation), at
its own expense and with legal counsel of its own choice, to bring suit (or
take other appropriate legal action) against any actual, alleged or threatened
infringement of the Schering Patent Rights in the Field.  EPIX shall have the right, at its own
expense, to be represented in any such action by Schering by counsel of EPIX’s
own choice; provided, however, that under no circumstances shall
the foregoing affect the right of Schering to control the suit as described
above.  If Schering does not file any
action or proceeding against any such material infringement within six (6)
months after the later of (i) EPIX’s notice to Schering under this
Section 8.3.3, (ii) Schering’s notice to EPIX under this
Section 8.3.3, or (iii) a written request from EPIX to take action
with respect to such infringement, then EPIX shall have the right (but not the
obligation), at its own expense, to bring suit (or take other appropriate legal


 


19

















 


action)
against such actual, alleged or threatened infringement, with legal counsel of
its own choice, but shall not be permitted to settle any such suit without the
prior consent of Schering, which consent shall not be unreasonably withheld.


 


(c)                                  Monetary
Awards.  Section 8.3.1(c) shall
apply accordingly.


 


(d)                                 Declaratory
Actions.  Section 8.3.2 shall apply
accordingly.


 


8.4.                              If
either Party brings an action or proceeding under Section 8.3 above, the
other Party agrees to be joined as party plaintiff if necessary to prosecute
such action or proceeding, and to give the Party bringing such action or
proceeding reasonable assistance and authority to file and prosecute the suit; provided,
however, that neither Party shall be required to transfer any right,
title or interest in or to any property to the other Party or any Third Party
to confer standing on a Party hereunder.


 


ARTICLE 9:  CONFIDENTIALITY


 


9.1.                              Nondisclosure Obligations.


 


9.1.1.                     General.  Except as provided in this Article 9, during
the Term and for a period of ten (10) years thereafter, both Parties shall
maintain in confidence and use only for purposes specifically authorized under
this Agreement (i) information and data received from the other Party resulting
from or related to the development of the Thrombus Compound(s) and/or Licensed
Products and (ii) all information and data not described in clause (i) but
supplied by the other Party under this Agreement marked “Confidential.”  For purposes of this Article 9, information
and data described in clause (i) or (ii) shall be referred to as “Information.”


 


9.1.2.                     Limitations.  To the extent it is reasonably necessary or
appropriate to fulfill its obligations or exercise its rights under this
Agreement, a Party may disclose Information it is otherwise obligated under
this Section 9.1 not to disclose to its Affiliates, Sublicensees,
consultants, outside contractors and clinical investigators, on a need-to-know
basis on condition that such entities or persons enter into written agreements
to keep the Information confidential for the same time periods and to the same
extent as such Party is required to keep the Information confidential. In
addition a Party or its Affiliates or Sublicensees may disclose such
Information to government or other regulatory authorities to the extent that
such disclosure is reasonably necessary to obtain patents or authorizations to
conduct clinical trials of, and to commercially market, the Thrombus
Compound(s) and/or Licensed Products. 
However, for the avoidance of doubt, the Parties state that neither
Schering nor EPIX shall disclose pre-clinical or clinical data or the contents
or pre-clinical or clinical study, reports derived from studies of Licensed
Products that has been received from the other Party to advertising agencies,
marketing research consultants, customers, healthcare professionals, consumers
or regulatory agencies without the prior written approval of the other Party.


 


The obligation
not to disclose Information shall not apply to any part of such Information
that: (i) is or becomes part of the public domain other than by unauthorized
acts of the Party


 


20

















 


obligated not to disclose such
Information or those of its Affiliates or Sublicensees; (ii) can be shown by
competent evidence to have been disclosed to the receiving Party or its or
Sublicensees by a Third Party, provided, that such Information was not obtained
by such Third Party directly or indirectly from the other Party under this
Agreement pursuant to a confidentiality agreement; (iii) can be shown by
competent evidence, prior to disclosure under this Agreement, to already have
been in the possession of the receiving Party or its Affiliates or
Sublicensees, provided, that such Information was not obtained directly or
indirectly from the other Party under this Agreement pursuant to a
confidentiality agreement; (iv) can be shown by competent evidence to have been
independently developed by the receiving Party or its Affiliates without breach
of any of the provisions of this Agreement; or (v) is disclosed by the
receiving Party pursuant to interrogatories, requests for information or
documents, subpoena, civil investigative demand issued by a court or
governmental agency or as otherwise required by law; provided, that, the
receiving Party notifies the other Party immediately upon receipt thereof so
that such other Party (with the cooperation of the receiving Party) can seek a
protective order or other order limiting or preventing disclosure; and
provided, further, that the disclosing Party furnishes only that portion of the
Information which it is advised by counsel is legally required under the circumstances.


 


9.2.                              Terms of this Agreement.  Except as provided in Section 9.3
hereof, EPIX and Schering each agree not to disclose any terms or conditions of
this Agreement to any Third Party without the prior written consent of the
other Party, except as required by applicable law.  If either Party determines that it is required to file this
Agreement with the Securities and Exchange Commission or other governmental
agency for any reason, such Party shall request confidential treatment of such
portions of this Agreement as the Parties shall together determine is
appropriate.  Notwithstanding the
foregoing, prior to execution of this Agreement, EPIX and Schering have agreed
upon the substance of information that can be used as a routine reference in
the usual course of business to describe the terms of this transaction, and
EPIX and Schering may disclose such information, as modified by mutual
agreement from time to time, without the other Party’s consent as may be
necessary from time to time.


 


9.3.                              Publications.


 


9.3.1.                     Procedure.  Each Party recognizes the mutual interest in
obtaining patent protection for inventions that arise under this
Agreement.  In the event that either
Party, its employees or consultants or any Third Party under contract to such
Party wishes to make a publication (including any oral disclosure made without
obligation of confidentiality) relating to work performed under this Agreement
(the “Publishing Party”), such Party shall transmit to the other Party (the
“Reviewing Party”) a copy of the proposed written publication at least thirty
(30) days prior to submission for publication, or an abstract of such oral
disclosure at least seven (7) days prior to submission of the abstract or the
oral disclosure, whichever is earlier. The Reviewing Party shall have the right
(a) to propose modifications to the publication for patent reasons, (b) to
request a delay in publication or presentation in order to protect patentable
information, or (c) to request that the information be maintained as a trade
secret.


 


9.3.2.                     Modifications;
Delay: Resolution.  If the Reviewing
Party requests a modification to the publication for patent reasons, the
proposed publication shall not be 


 


21

















 


submitted until the Parties have agreed to
appropriate modifications.  If the
Reviewing Party requests a delay as described in Section 9.3.1, the
Publishing Party shall delay submission or presentation of the publication for
a period of ninety (90) days to enable patent applications protecting each
Party’s rights in such information to be filed.  If the Reviewing Party requests that information be maintained as
a trade secret, the proposed publication shall not be disclosed until such information
is deleted therefrom.


 


9.4.                              Injunctive Relief.  The Parties hereto understand and agree that remedies, at law may
be inadequate to protect against any breach of any of the provisions of this
Article 9 by either Party or their employees, agents, officers or directors or
any other person acting in concert with it or on its behalf.  Accordingly, each Party shall be entitled to
the granting of injunctive relief or other equitable relief by a court of
competent jurisdiction against any action that constitutes any such breach of
this Article 9, in addition to any monetary damages to which a Party may be
entitled.


 


ARTICLE 10:  REPRESENTATIONS AND
WARRANTIES


 


10.1.                        Representations and Warranties.  EPIX and Schering each represents and
warrants to the other, as of the Effective Date as follows:


 


10.2.                        Organization. 
It is a corporation duly organized, validly existing and is in good
standing under the laws of the jurisdiction of its organization, is qualified
to do business and is in good standing as a foreign corporation in each
jurisdiction in which the performance of its obligations hereunder requires
such qualification and has all requisite power and authority, corporate or
otherwise, to conduct its business as now being conducted, to own, lease and
operate its properties and to execute, deliver and perform this Agreement.


 


10.3.                        Authorization. 
The execution, delivery and performance by it of this Agreement (a) have
been duly authorized by all necessary corporate action and (b) do not and will
not violate any provision of any agreement, law, rule, regulation, order, writ,
judgment, injunction, decree, determination or award presently in effect having
applicability to it or any provision of its charter documents.


 


10.4.                        No Inconsistent Obligation.  It is not under any obligation to any
person, or entity, contractual or otherwise, that is conflicting or
inconsistent in any respect with the terms of this Agreement or that would
impede the diligent and complete fulfillment of its obligations hereunder and
that it has all power and authority under all instruments or agreements to
which it is a Party to enter into this Agreement and to perform its obligations
hereunder.


 


10.5.                        Warranty Disclaimer.  EXCEPT AS OTHERWISE EXPRESSLY PROVIDED IN
THIS AGREEMENT, NEITHER PARTY MAKES ANY WARRANTY WITH RESPECT TO ANY
TECHNOLOGY, GOODS, SERVICES, RIGHTS OR OTHER SUBJECT MATTER OF THIS AGREEMENT
AND HEREBY DISCLAIMS WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR
PURPOSE AND NONINFRINGEMENT WITH RESPECT TO ANY AND ALL OF THE FOREGOING.


 


22

















 


ARTICLE 11:  INDEMNITY


 


11.1.                        Claim.  For
purposes of this Article 11 “Claim” shall mean any and all Third Party suits,
actions, claims, demands, liabilities, expenses, and/or losses, including
without limitation reasonable attorneys’ fees, based upon, arising in
connection with, or resulting from the development, clinical study in humans,
or commercialization of the Thrombus Compound(s) and/or Licensed Products, but
excluding any suits, actions, claims, demands, liabilities, expenses, and/or
losses based upon, arising in connection with, or resulting from infringement
of the intellectual property rights of any Third Party or Third Parties.


 


11.2.                        Schering Indemnity Obligations.  Subject to the provisions of Sections 11.3
and 11.4, Schering agrees to defend, indemnify and hold EPIX, its Affiliates
and their respective directors, officers, employees and agents harmless from
(each, an “EPIX Indemnitee”) all Claims against EPIX, its Affiliates or their
respective directors, officers, employees or agents solely based upon, arising
in connection with or resulting from (a) actual or asserted violations of any
applicable law or regulation by Schering, its Affiliates, Sublicensees, or
agents by virtue of which any Thrombus Compound(s) or Schering Licensed Product
is developed, distributed or sold by Schering shall be alleged or determined to
be adulterated, misbranded, mislabeled or otherwise not in compliance with such
applicable law or regulation, (b) the manufacture, use, sale, distribution of a
Thrombus Compound(s) or Schering Licensed Product by Schering, its Affiliates,
Sublicensees, or agents; (c) any negligent or willful or intentional act or
omission to act by Schering, its Affiliates, Sublicensees, or agents in any
manner in connection with performance hereunder; or (d) the breach of any
representation or warranty of Schering in this Agreement.


 


11.3.                        EPIX Indemnity Obligations.  Subject to the provisions of Sections 11.2
and 11.4, EPIX agrees to defend, indemnify and hold Schering, its Affiliates
and their respective directors, officers, employees and agents harmless from
all Claims against Schering, its Affiliates or their respective directors,
officers, employees or agents (each, a “Schering Indemnitee”) solely based
upon, arising in connection with or resulting from (a) actual or asserted
violations of any applicable law or regulation by EPIX, its Affiliates,
Sublicensees, or agents by virtue of which any Thrombus Compound(s) or EPIX
Licensed Product is developed, distributed or sold by EPIX shall be alleged or
determined to be adulterated, misbranded, mislabeled or otherwise not in
compliance with such applicable law or regulation, (b) the manufacture, use,
sale, distribution of a Thrombus Compound(s) or an EPIX Licensed Product; (c)
any negligent or willful or intentional act or omission to act by EPIX, its
Affiliates or agents in any manner in connection with performance hereunder; or
(d) the breach of any representation or warranty of EPIX in this Agreement.


 


11.4.                        Procedure.  An EPIX Indemnitee and/or a Schering Indemnitee (each, an
“Indemnitee”) that intends to claim indemnification under Sections 11.2 or 11.3
shall promptly notify the other Party (the “Indemnitor”) of the Claim in respect
of which the Indemnitee intends to claim such indemnification, and the
Indemnitor shall assume the defense thereof with counsel mutually satisfactory
to the Parties; provided, however, that an Indemnitee shall have the right to
retain its own counsel, with the fees and expenses to be paid by the
Indemnitor, if representation 


 


23

















 


of such Indemnitee in the opinion of the
Parties would be inappropriate due to actual or potential differing interests
between such Indemnitee and any other Party represented by such counsel in such
proceedings. An Indemnitee shall not be entitled to indemnification under
Sections 11.2 or 11.3 if any settlement or compromise of a Claim is effected by
the Indemnitee without the consent of the Indemnitor, which consent shall not
be unreasonably withheld or delayed. 
The failure to deliver notice to the Indemnitor within a reasonable time
after notice of a Claim, if prejudicial to its ability to defend such action,
shall relieve such Indemnitor of any liability to the lndemnitee under Sections
11.2 or 11.3.  The Indemnitee under
Sections 11.2 or 11.3, its employees and agents (and those of any indemnified
Affiliates or other Indemnitees), shall cooperate fully with the Indemnitor and
its legal representatives in the investigation and defense of the Claim covered
by this indemnification.  Any Costs paid
by an Indemnitor shall be without prejudice to the Indemnitor’s right to
contest the Indemnitee’s right to be indemnified, and subject to refund in the
event that the Indemnitor is ultimately held not to be obligated to indemnify
the Indemnitee.


 


11.5.                        Limited Liability.  NOTWITHSTANDING ANYTHING TO THE CONTRARY IN THIS AGREEMENT,
NEITHER EPIX NOR SCHERING WILL BE LIABLE WITH RESPECT TO ANY SUBJECT MATTER OF
THIS AGREEMENT UNDER ANY CONTRACT, NEGLIGENCE, STRICT LIABILITY OR OTHER LEGAL
OR EQUITABLE THEORY FOR PUNITIVE DAMAGES OR LOST PROFITS.


 


ARTICLE 12:  EXPIRATION AND TERMINATION


 


12.1.                        Term.  The term
of this Agreement shall commence on the Effective Date and shall continue until
the last to occur of the following: (i) the expiration or termination of the
Proof of Concept Development Program, (ii) the expiration of the License Term
or (iii) the expiration of the EPIX Royalty Term (the “Term”).


 


12.2.                        Termination without Cause.  Schering shall have the right to partially
terminate this Agreement without cause with regard to (i) the Proof of Concept
Development Program at any time prior to expiration of the relevant Proof of
Concept Development Period, and (ii) any exclusive or non-exclusive license
granted to Schering hereunder, upon sixty (60) days prior written notice to
EPIX. Following such termination, all rights and licenses granted to Schering
under this Agreement shall terminate and Schering shall return or destroy all tangible
manifestations of EPIX’s Information and EPIX’s Technology. If all or part of
the work under the applicable Proof of Concept Development Program is
terminated for any reason, then Schering shall have no obligation to continue
payment thereafter of installments under Section 3.2; provided, however,
that Schering shall pay reasonable, non-cancelable, Third Party expenses
incurred by EPIX up until the effective date of the termination. EPIX shall use
good faith effort to limit such obligations following such notice from
Schering. For the avoidance of doubt, if Schering terminates this Agreement
pursuant to clause (ii) of this Section 12.2, the rights and licenses granted
to Schering under Sections 4.1.2 and 5.1.2 hereof shall immediately terminate
with regard to the relevant exclusive or non-exclusive license terminated by
Schering hereunder, and EPIX shall have the sole right, but not the obligation,
under the license granted pursuant to Section 5.1.1 hereof to further develop
and commercialize any Schering Licensed Product 


 


24

















 


covered by the terminated license (thereafter
becoming an EPIX Licensed Product as defined in Section 4.1.2).


 


12.3.                        Termination for Material Breach.  If either Party commits a material breach of
this Agreement (a “Default”), the other Party may notify the breaching Party in
writing of such breach, setting forth the nature of the breach in reasonable
detail.  If the breaching Party fails to
cure such breach within thirty (30) days (in the case of a payment due under
this Agreement) or sixty (60) days (in the case of any other breach) of the
receipt of the foregoing notice from the non-breaching Party, then, subject to
the terms of this Section 12.3, the non-breaching Party may terminate (i) the
respective Part of this Agreement which is impacted by the uncured material
breach, or (ii) if the breach is of a general nature having a material impact
on all Parts, the entire Agreement effective immediately upon a second written
notice to the breaching Party. The right of either Party to terminate this
Agreement as herein above provided shall not be affected in any way by its
waiver of, or failure to take action with respect to any previous default.


 


12.3.1.               Termination by
Schering for EPIX Default.  Upon a
termination of this Agreement by Schering because of a Default by EPIX, subject
to the notice and cure provisions set forth in this Section 12.3, (i) all
rights and licenses granted to EPIX pursuant to Section 5.1.1 hereof shall
survive such termination; provided, however, the EPIX Royalty
Term, as defined in Section 1.14, shall be extended as if the phrase “[*****]
of the Schering Payment” were deleted and replaced by the phrase “[*****] of
the Schering Payment” and (ii) all rights, licenses and options granted to
Schering hereunder shall survive such termination, provided, however,
Schering shall pay, for the remainder of the License Term, in lieu of any
payments it would otherwise owe to EPIX under this Agreement, [*****] of
milestones and royalty payments equal to [*****] of the royalty payments that
would otherwise apply with respect to Schering Licensed Products under
Section 6.1. hereof.


 


12.3.2.               Termination by
EPIX for Schering Default.


 


(a)                                  Upon a termination of
this Agreement by EPIX because of any Default by Schering, except for a Default
subject to Sections 12.3.2(b) or 12.3.2 (c) below, subject to the notice
and cure provisions set forth in Section 12.3, (i) all rights and licenses
granted to Schering pursuant to Section 5.1.2 hereof hereunder shall survive
such termination; provided, however, all milestone and royalty
obligations of Schering pursuant to Section 6.1 hereof, shall be increased
by [*****] respectively, (ii) the EPIX Royalty Term, as defined in Section
1.15, shall be shortened as if the phrase “[*****]of the Schering Payment” were
deleted and replaced by the phrase “[*****] of the Schering Payment” and (iii)
all rights, licenses and options granted to EPIX hereunder shall survive
termination, provided, however, EPIX shall pay, for the remainder
of the EPIX Royalty Term, in lieu of any payments it would otherwise owe to
Schering under this Agreement, royalty payments equal to [*****] percent of the
royalty payments that would otherwise apply with respect to EPIX Licensed
Products under Section 6.2 hereof.


 


12.4.                        Termination for Failure of
Schering to use Due Diligence. 
Notwithstanding any other provisions of this Agreement, in case of any
failure by Schering to use due diligence as



 


25

















 


required pursuant to
Section 5.3 hereof, EPIX may, in its sole discretion terminate the
relevant licenses granted under Section 5.1.2 hereof upon written notice
to Schering; provided  that Schering has not cured such failure
within ninety (90) days of EPIX’s notice to Schering of such alleged failure.
After a termination under this Section 12.4 EPIX shall have the sole right, but
not the obligation, under the license granted pursuant to Section 5.1.1 hereof
to further develop and commercialize such Schering Licensed Product
(thereafter, becoming an “EPIX Licensed Product”), subject to payment of
royalties as provided in Section 6.2.2 and the payment of [*****] of Sublicense
Income received by EPIX in connection with the sublicense of rights to such
EPIX Licensed Product to a Third Party until the date upon which
the aggregate total of such Sublicense Income and royalties paid equals [*****]
of the previously unreimbursed Development Costs incurred by Schering for the relevant Schering Licensed Product.


 


12.5.                        Effects Termination on Sublicenses.  Notwithstanding the foregoing, termination
of this Agreement by Schering under Section 12.3.1 or by EPIX pursuant to
Sections 12.3.2 or 12.4 shall not be construed as a termination of any valid
sublicense of any Sublicensee hereunder, and thereafter each such Sublicensee
shall be considered a direct licensee of the terminating Party, provided that
(i) such Sublicensee is then in full compliance with all terms and conditions
of its sublicense, (ii) all accrued payments obligations to terminating Party
have been paid, and (iii) such Sublicensee agrees in writing to assume all
applicable obligations of the non-terminating Party under this Agreement.


 


12.6.                        Termination Upon Insolvency.  This Agreement may be terminated by either
Party upon notice to the other Party should such other Party:  (a) consent to the appointment of a receiver
or a general assignment for the benefit of creditors, or (b) file or consent to
the filing of a petition under any bankruptcy or insolvency law or have any
such petition filed against it which has not been stayed within sixty (60) days
of such filing.


 


12.7.                        Rights in Bankruptcy.  All rights and licenses granted under or
pursuant to this Agreement are, and shall otherwise be deemed to be, for
purposes of Section 365(n) of the U.S. Bankruptcy Code, licenses of right
to “intellectual property” as defined under Section 101 of the U.S.
Bankruptcy Code.


 


12.8.                        Accrued Rights; Surviving
Obligations.  Termination of
this Agreement for any reason shall be without prejudice to any rights that
shall have accrued to the benefit of a Party prior to or on account of such
termination.  All remedies provided
hereunder or elsewhere are cumulative. 
Sections 7.3, 12.7 and 13.5 and Articles 8, 9, 10 and 11 of this
Agreement shall survive the termination of this Agreement for any reason and
Section 1 hereof shall survive such termination to the extent any terms
defined therein are used in such other surviving provisions.


 


ARTICLE 13:  MISCELLANEOUS


 


13.1.                        Force Majeure. 
Neither Party shall be held liable or responsible to the other Party nor
be deemed to have defaulted under or breached this Agreement for failure or
delay in fulfilling or performing any term of this Agreement when such failure
or delay is caused by or results from causes beyond the reasonable control of
the affected Party, including but not limited 


 


26

















 


to fire, floods, embargoes, war, acts of war
(whether war is declared or not), insurrections, riots, civil commotions,
strikes, lockouts or other labor disturbances, acts of God or acts, omissions
or delays in acting by any governmental authority or the other Party; provided,
however, that the Party so affected shall use reasonable commercial efforts to
avoid or remove such causes of nonperformance, and shall continue performance
hereunder with reasonable dispatch whenever such causes are removed. Either
Party shall provide the other Party with prompt written notice of any delay or
failure to perform that occurs by reason of force majeure.  The Parties shall mutually seek a resolution
of the delay or the failure to perform as noted above.


 


13.2.                        Assignment. 
This Agreement may not be assigned or otherwise transferred by either
Party without the prior written consent of the other Party; provided, however,
that either EPIX or Schering may, without such consent, assign its rights and
obligations under this agreement: (i) to any Affiliate, or (ii) in connection
with a merger, consolidation or sale of substantially all of such Party’s
assets to an unrelated Third Party; provided, however, with
respect to this Subsection (ii), that such Party’s rights and obligations under
this Agreement shall be assumed in writing by its successor in interest in any
such transaction and shall not be transferred separately from all or
substantially all of its diagnostic imaging business assets.  Any purported assignment in violation of the
preceding sentence shall be void.  Any
permitted assignee shall assume all obligations of its assignor under this
Agreement.


 


13.3.                        Severability. 
Each Party hereby agrees that it does not intend, by its execution
hereof, to violate any public policy, statutory or common laws, rules,
regulations, treaty or decision of any government agency or executive body
thereof of any country or community or association of countries.  Should one or more provisions of this
Agreement be or become invalid, the Parties hereto shall substitute, by mutual
consent, valid provisions for such invalid provisions which valid provisions in
their economic and other effects are sufficiently similar to the invalid
provisions that it can be reasonably assumed that the Parties would have
entered into this Agreement with such valid provisions.  In case such valid provisions cannot be
agreed upon, the invalidity of one or several provisions of this Agreement
shall not affect the validity of this Agreement as a whole or the validity of
any portions hereof, unless the invalid provisions are of such essential
importance to this Agreement that it is to be reasonably assumed that the
Parties would not have entered into this Agreement without the invalid
provisions.


 


13.4.                        Notices.  Any
consent, notice or report required or permitted to be given or made under this
Agreement by one of the Parties hereto to the other shall be in writing,
delivered personally or by courier, postage prepaid (where applicable),
addressed to such other Party at its address indicated below, or to such other
address as the addressee shall have last furnished in writing to the addressor
and shall be effective upon receipt by the addressee.


 


	
  If to EPIX:

  	
   

  	
  EPIX Medical, Inc.

  
	
   

  	
   

  	
  71 Rogers Street

  
	
   

  	
   

  	
  Cambridge, Massachusetts 02142-1118

  
	
   

  	
   

  	
  Attention:  Chief Executive
  Officer

  
	
   

  	
   

  	
   

  
	
  with a copy to:

  	
   

  	
  Mintz Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

  



 


27

















 


	
   

  	
   

  	
  One Financial Center

  
	
   

  	
   

  	
  Boston, Massachusetts 02111

  
	
   

  	
   

  	
  Attention:  William T. Whelan,
  Esq.

  
	
   

  	
   

  	
   

  
	
  If to Schering:

  	
   

  	
  Schering Aktiengesellschaft

  
	
   

  	
   

  	
  13342 Berlin

  
	
   

  	
   

  	
  Germany

  
	
   

  	
   

  	
  Attention:  Head of Diagnostic
  Imaging SBU

  
	
   

  	
   

  	
   

  
	
  with a copy to:

  	
   

  	
  Schering Aktiengesellschaft

  
	
   

  	
   

  	
  13342 Berlin

  
	
   

  	
   

  	
  Germany

  
	
   

  	
   

  	
  Attention:  Legal Department

  



 


13.5.                        Applicable Law.  This Agreement shall be governed by and construed in accordance
with the laws of the State of New York, without giving effect to the choice of
laws provisions thereof.


 


13.6.                        Dispute Resolution.


 


13.6.1.               Subject to any
other dispute resolution principles and mechanisms set forth in this Agreement
the Parties hereby agree that they will attempt in good faith to, resolve any
controversy or claim arising out of or relating to this Agreement promptly by
negotiations.  If a controversy or claim
should arise hereunder, the representatives of the Parties will confer at least
once and will attempt to resolve the matter.  
If the matter has not been resolved within sixty (60) days of their
first meeting, the representatives shall refer the matter to the Chief
Executive Officer of EPIX and the Head of Schering’s Strategic Business Unit
(SBU) Diagnostics (DG) & Radiopharmaceuticals (RP).  If the matter has not been resolved within
sixty (60) days of the first meeting of the Chief Executive Officer of EPIX and
the Head of Schering’s SBU DG & RP (which period may be extended by mutual
agreement), then the matter shall be decided by the Head of Schering’s SBU DG
& RP if the dispute is related to development issues or the financing
thereof. Subject to rights to injunctive relief and specific performance, and
unless otherwise specifically provided for herein, any other controversy or
claim arising out of or relating to this Agreement, or the breach thereof, will
be settled as set forth in Section 13.6.2.


 


13.6.2.               All disputes,
controversies or differences which may arise between the Parties out of or in
relation to this Agreement or any default or breach thereof may be resolved by
arbitration in accordance with the commercial arbitration rules (except as
otherwise specified herein) of the American Arbitration Association by three
arbitrators, one to be selected by each of the Parties from a list of
arbitrators supplied by the American Arbitration Association within thirty days
of receipt of such list, and a third to be selected by the first two from such
list within a reasonable time. The arbitrators shall be experienced in the
subject matter of the arbitration (for example, arbitration of a scientific
issue would require appointment of arbitrators with knowledge of the relevant
area of science).  The arbitration shall
take place in New York, New York. 
Either Party may initiate an arbitration by written notice to the other
Party, such notice 


 


28

















 


shall set forth the particulars of the issue
to be arbitrated in sufficient detail to permit the Party receiving the notice
to conduct an investigation and formulate a position (such notice shall not
preclude the Parties from attempting to informally settle their
differences).  The arbitrators shall
select one of their number to serve as presiding arbitrator, with the
responsibility for handling administrative matters relating to the
arbitration.  Within sixty days of
written notice to the Parties of the selection of the third arbitrator, each
Party shall contemporaneously submit in writing to the presiding arbitrator and
the other Party its position for the resolution of the issue that is the
subject matter of the arbitration.  At
the request of either Party, to be submitted to the presiding arbitrator and
the other Party within sixty days receipt of the written position of the other
Party, the arbitrators shall schedule in-person presentations of the Parties
(at which both Parties and all three arbitrators shall be present), which may
include the presentation of witnesses, oral argument, or both, at the discretion
of each of the Parties, and which shall not exceed five hours for each of the
Parties.  The in-person presentations
shall be scheduled by the arbitrators at their convenience and the reasonable
convenience of the Parties, but shall be held within ninety and one hundred
fifty days of receipt by the presiding arbitrator of the first request for an
in-person presentation.  If neither
Party makes a request for an in-person presentation, then the decision of the arbitrators
shall be based solely on the written positions of the Parties.  The arbitrators shall have the power only to
select one of the Party’s positions, and the decision of any two of the
arbitrators shall be the result of the arbitration.  The non-prevailing Party shall bear the costs of the
arbitration.  The decision resulting
from the arbitration provided for herein shall be final and binding on the
Parties hereto.  Notwithstanding the
above, without resort to arbitration in the first instance, either Party has
the right to bring suit against the other Party for (i) any breach of such
other Party’s duties of confidentiality pursuant to Article 9 of this
Agreement and (ii) any infringement of its own proprietary rights by the other
Party.  Judgment upon the arbitrators’
award may be entered in any court of competent jurisdiction.  The Parties agree not to institute any
litigation or proceedings against each other in connection with this Agreement
unless they have complied with the provisions of this Section 13.6, as
they may be applicable, unless otherwise provided herein.


 


13.7.                        Public Announcements.  Any provision of Article 9 to the contrary
notwithstanding, the Parties agree that press releases and other announcements
to be made by either of them in relation to this Agreement shall be subject to
the written consent of the other Party, which consent shall not be unreasonably
withheld or delayed, except to the extent that any such press release is
required to be made by law or the rules of any relevant national stock exchange
and the consent of the other Party is not obtained after reasonable efforts to
do so.  The Parties will agree to issue
a joint press release immediately following the execution of this Agreement,
the form and content of which shall be reasonably satisfactory to both Parties.


 


13.8.                        Entire Agreement; Amendment.  This Agreement, together with the exhibits
hereto, contains the entire understanding of the Parties with respect to the
subject matter hereof.  All express or
implied agreements and understandings, either oral or written, heretofore made
are expressly superceded merged by this Agreement.  This Agreement may be amended, or any term hereof modified, only
by a written instrument duly executed by both Parties hereto.


 


29

















 


13.9.                        Headings. 
The captions to the several Articles and Sections hereof are not a part
of this Agreement, but are merely guides or labels to assist in locating and
reading the several Articles and Sections hereof.


 


13.10.                  Agreement Not to Solicit Employees.  During the Term and for a period of two (2)
years following the expiration pursuant to Section 13.1 or termination
pursuant to Sections 12.2., or 12.3. of this Agreement, EPIX and Schering
agree not to seek to persuade or induce any employee of the other company to
discontinue his or her employment with that company in order to become employed
by or associated with any business, enterprise or effort that is associated
with its own business.


 


13.11.                  Exports.  The
Parties acknowledge that the export of technical data, materials or products is
subject to the exporting Party receiving any necessary export licenses and that
the Parties cannot be responsible for any delays attributable to export
controls which are beyond the reasonable control of either Party.  EPIX and Schering agree not to export or
re-export, directly or indirectly, any information, technical data, the direct
product of such data, samples or equipment received or generated under this
Agreement in violation of any applicable export control laws or governmental
regulations.  EPIX and Schering agree to
obtain similar covenants from their licensees, Sublicensees and contractors
with respect to the subject matter of this Section 13.11.


 


13.12.                  Waiver.  The
waiver by either Party hereto of any right hereunder or the failure to perform
or of a breach by the other Party shall not be deemed a waiver of any other
right hereunder or of any other breach or failure by said other Party whether
of a similar nature or otherwise.


 


13.13.                  Counterparts. 
This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.


 


13.14.                  Independent Contractors; Negation
of Partnership.  The
relationship of EPIX and Schering established by this Agreement is that of
independent contractors, and nothing contained in this Agreement shall be
construed to give either Party the power to direct or control the day-to-day
activities of the other, or allow one Party to create or assume an obligation
on behalf of the other Party for any purpose whatsoever.  This Agreement is not intended to create a
partnership between EPIX and Schering for United States federal income tax
purposes (as defined in Section 761 of the Internal Revenue Code), for any
state or local jurisdiction in the United States, or for any country other than
the United States.  Therefore, there is
no requirement in the United States to file Form 1065, United States Partnership
Return of Income, or any similar state or local income tax return in any
political subdivision of the United States, or any similar tax document in any
country other than the United States, in regard to the contractual relationship
described in this Agreement.


 


13.15.                  Ambiguities. 
The Parties acknowledge and agree that: (i) each Party and its counsel
reviewed and negotiated the terms and provisions of this Agreement and have 


 


30

















 


contributed to its revision; (ii) the rule of
construction to the effect that any ambiguities are resolved against the
drafting Party shall not be employed in the interpretation of this Agreement;
and (iii) the terms and provisions of this Agreement shall be construed fairly
as to all Parties hereto and not in a favor of or against any Party, regardless
of which Party was generally responsible for the preparation of this Agreement.


 


[Signature page shall follow]


 


31

















 


IN WITNESS
WHEREOF, the Parties have executed this Agreement as of the date first set
forth above.


 


 


	
  EPIX MEDICAL, INC.

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
  By:

  	
   

  	
   

  	
   

  
	
   

  	
  Michael D. Webb

  	
   

  
	
   

  	
  Chief Executive Officer

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
  SCHERING AKTIENGESELLSCHAFT

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
  By:

  	
   

  	
   

  	
   

  
	
   

  	
  Prof. Dr. Günter Stock

  	
   

  
	
   

  	
  Member of the Vorstand

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
  By:

  	
   

  	
   

  	
   

  
	
   

  	
  Hans-Michael Rook

  	
   

  
	
   

  	
  Head SBU DG & RP

  	
   

  
					



 


32

















 


Exhibit
1.12


 


EP-2104R


[*****]


 


33

















 


Exhibit 1.14


 


EPIX Patent Rights


 


	
  MET-8

  	
   

  	
  US Application

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-9

  	
   

  	
  US Application

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-14A

  	
   

  	
  US Application

  	
   

  	
  [*****]

  
	
  MET-14B

  	
   

  	
  US Application

  	
   

  	
  [*****]

  
	
  MET-14

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-16

  	
   

  	
  US Publication

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  PCT

  	
   

  	
  [*****]

  



 


34

















 


Exhibit 1.42


 


Schering
Patent Rights


 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  02346A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/FEB/2003

  
	
  02346A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  NO

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/FEB/2003

  
	
  02346A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/SEP/2004

  
	
  02346A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  31/DEC/2007

  
	
  02346A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/FEB/2003

  
	
  02346A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  21/JUN/2005

  
	
  02346A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/FEB/2003

  
	
  02346A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/FEB/2003

  
	
  02346A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2001

  
	
  02346A

  	
   

  	
  DE 0071564

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  02346A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/SEP/2003

  
	
  02346A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/FEB/2003

  
	
  02346A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/AUG/2005

  
	
  02346A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  02346A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/JUL/2007

  
	
  02346A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/JUL/2002

  
	
  02346A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  22/JUL/2002

  
	
  02346A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/FEB/2003

  
	
  02346A

  	
   

  	
  CA

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  03/MAR/2004

  
	
  02346A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  



 


35

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/OCT/2013

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/JUN/2008

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/MAR/2004

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/MAR/2004

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/NOV/2011

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/MAR/2004

  
	
  02491A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  SG

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  02491A

  	
   

  	
  IT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/MAR/2004

  
	
  02491A

  	
   

  	
  SG

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  GB

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  10/JAN/2004

  
	
  02491A

  	
   

  	
  NL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JAN/2004

  
	
  02491A

  	
   

  	
  LU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  BE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  GR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  GB

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  AT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  15/SEP/2011

  
	
  02491A

  	
   

  	
  ES

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/NOV/2004

  
	
  02491A

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  CH

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2006

  
	
  02491A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  09/APR/2004

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/JUN/2008

  
	
  02491A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  



 


36

















 


	
  File number

  	
   

  	
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  Grant number

  	
   

  	
  Expiry

  
	
  02491A

  	
   

  	
  SG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  SG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JAN/2004

  
	
  02575A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  11/JAN/2004

  
	
  02575A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  11/JAN/2004

  
	
  02969A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUL/2007

  
	
  02969A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  30/JAN/2018

  
	
  02969A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2006

  
	
  02969A

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2007

  
	
  02969A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2007

  
	
  02969A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2007

  
	
  02969A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/JUL/2007

  
	
  02969A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2007

  
	
  02969A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/DEC/2007

  
	
  02969A

  	
   

  	
  SE

  	
   

  	
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  [*****]

  	
   

  	
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  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/FEB/2016

  
	
  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02969A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2007

  
	
  03035A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/NOV/2007

  
	
  03035A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  03035A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  14/SEP/2010

  
	
  03035A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/NOV/2006

  
	
  03035A

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  10/NOV/2007

  
	
  03035A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/NOV/2007

  
	
  03035A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/NOV/2007

  
	
  03035A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/NOV/2007

  



 


37

















 


	
  File number

  	
   

  	
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  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  03035A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/NOV/2007

  
	
  03035A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/NOV/2007

  
	
  03035A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  06/MAR/2008

  
	
  03035A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/MAR/2009

  
	
  03035A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  03035A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/MAR/2016

  
	
  03035A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  30/NOV/2007

  
	
  03035A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  03035A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/NOV/2007

  
	
  03193A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/FEB/2009

  
	
  03193A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  03193A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/OCT/2014

  
	
  03193A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/OCT/2014

  
	
  03226A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/MAR/2009

  
	
  03226A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/FEB/2011

  
	
  03226A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50116A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  11/AUG/2009

  
	
  50116A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/JAN/2011

  
	
  50235A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2013

  
	
  50235A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/JUN/2010

  
	
  50235A

  	
   

  	
  DD

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2008

  
	
  50235A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/JUN/2010

  
	
  50235A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/JUN/2010

  
	
  50235A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/JUN/2010

  
	
  50235A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/NOV/2011

  
	
  50235A

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  



 


38

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  50235A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/JUN/2010

  
	
  50235A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/NOV/2010

  
	
  50235A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUN/2010

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/AUG/2015

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/MAR/2017

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  09/DEC/2014

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50235A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50298A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/NOV/2010

  
	
  50298A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/SEP/2014

  
	
  50298A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/JUL/2014

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  15/NOV/2011

  
	
  50298A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  21/NOV/2010

  
	
  50340A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2016

  
	
  50340A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  



 


39

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  50340A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JAN/2015

  
	
  50340A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2013

  
	
  50340A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/JAN/2015

  
	
  50340A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/MAR/2016

  
	
  50340A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/MAR/2016

  
	
  50340A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  GR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/MAR/2016

  
	
  50340A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2016

  
	
  50340A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/MAR/2016

  
	
  50340A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  50340A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  24/FEB/2017

  
	
  50340A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  SE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2016

  
	
  50340A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  09/NOV/2016

  
	
  50340A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50340A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50340A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50351A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/APR/2011

  
	
  50351A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/APR/2011

  
	
  50351A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/APR/2011

  
	
  50351A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/APR/2011

  
	
  50351A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/APR/2011

  
	
  50351A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/APR/2011

  
	
  50351A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/APR/2011

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  12/JAN/2016

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/APR/2011

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/DEC/2015

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/APR/2011

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



 


40

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/APR/2011

  
	
  50384A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/NOV/2011

  
	
  50384A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  50384A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2014

  
	
  50384A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/NOV/2011

  
	
  50396B

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  06/DEC/2011

  
	
  50396B

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  IL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  06/DEC/2012

  
	
  50396B

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  07/DEC/2012

  
	
  50396B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  06/DEC/2012

  
	
  50396B

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50396B

  	
   

  	
  AT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  BE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  FR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  LU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  NL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  ES

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  CH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  GR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  GB

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  SE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  MC

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  IT

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/DEC/2012

  



 


41

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  50449A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  11/MAY/2012

  
	
  50449A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  13/MAY/2012

  
	
  50449A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAY/2012

  
	
  50449A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/MAY/2012

  
	
  50449A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2012

  
	
  50449A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/MAY/2012

  
	
  50449A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/MAY/2012

  
	
  50449A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2012

  
	
  50449A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  07/MAY/2012

  
	
  50479A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUN/2012

  
	
  50479A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/MAY/2013

  
	
  50479A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  



 


42

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  50479A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  07/DEC/2012

  
	
  50479A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50580A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/SEP/2013

  
	
  50580A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/SEP/2012

  
	
  50580A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/SEP/2013

  
	
  50580A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/SEP/2013

  
	
  50580A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/SEP/2013

  
	
  50580A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  15/DEC/2015

  
	
  50580A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/SEP/2013

  
	
  50658A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JAN/2014

  
	
  50658A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  ID

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  10/MAR/2014

  
	
  50658A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2014

  
	
  50658A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  MY

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  31/JUL/2015

  
	
  50658A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  TH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  24/JAN/2014

  
	
  50658A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  11/MAR/2014

  
	
  50658A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/AUG/2014

  
	
  50658A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/JAN/2014

  
	
  50659A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/NOV/2014

  
	
  50659A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/NOV/2014

  
	
  50659A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/NOV/2014

  
	
  50659A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/NOV/2014

  
	
  50735A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/NOV/2013

  
	
  50735A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  



 


43

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  50735A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  06/NOV/2012

  
	
  50735A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/OCT/2013

  
	
  50735A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50784A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50856A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/APR/2014

  
	
  50856A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50856A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50856A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/MAY/2015

  
	
  51041A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2014

  
	
  51041A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2014

  
	
  51041A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2014

  
	
  51041A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2014

  
	
  51041A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2014

  
	
  51041A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51041A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/JUN/2015

  
	
  51081A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/JAN/2015

  
	
  51081A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/JAN/2015

  
	
  51081A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51108A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  



 


44

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51108A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  07/JUL/2014

  
	
  51108A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51108A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/JUN/2015

  
	
  51108A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/JUN/2015

  
	
  51121A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/JUN/2015

  
	
  51121A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/JUN/2015

  
	
  51126A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/JUN/2015

  
	
  51130A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2018

  
	
  51130A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  02/JUN/2017

  
	
  51130A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2018

  
	
  51130A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2012

  
	
  51130A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2018

  
	
  51130A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2018

  
	
  51130A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2018

  
	
  51130A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  01/JUN/2018

  
	
  51130A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/JUN/2018

  
	
  51130A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51130A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/JUN/2018

  
	
  51142A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  09/JUL/2016

  
	
  51142A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51142A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51152A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  21/FEB/2015

  
	
  51152A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  07/JUN/2015

  
	
  51155A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  01/MAR/2015

  
	
  51155A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  



 


45

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51155A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/FEB/2016

  
	
  51155A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/MAR/2010

  
	
  51155A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/MAR/2016

  
	
  51156A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JAN/2015

  
	
  51156A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  HK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/JAN/2016

  
	
  51156A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  



 


46

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51156A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/JAN/2016

  
	
  51164A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/AUG/2014

  
	
  51164A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  10/JUL/2015

  
	
  51164A 

  	
   

  	
  HU 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2015

  
	
  51164A 

  	
   

  	
  IL 

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2015 

  
	
  51164A 

  	
   

  	
  IL 

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2015 

  
	
  51164A 

  	
   

  	
  KR 

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  10/JUL/2015

  
	
  51164A 

  	
   

  	
  NO 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2015 

  
	
  51164A 

  	
   

  	
  US 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2015 

  
	
  51164A 

  	
   

  	
  US 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2015 

  
	
  51164A 

  	
   

  	
  US 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2015 

  
	
  51164A 

  	
   

  	
  US 

  	
   

  	
   

  	
   

  	
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  10/JUL/2015 

  
	
  51164A 

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
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  51201A 

  	
   

  	
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  08/MAY/2015 

  
	
  51201A 

  	
   

  	
  CN 

  	
   

  	
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  51201A 

  	
   

  	
  CN 

  	
   

  	
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  51201A 

  	
   

  	
  HK 

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  08/MAY/2015 

  
	
  51201A 

  	
   

  	
  HK 

  	
   

  	
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  08/MAY/2015 

  
	
  51229A 

  	
   

  	
  US 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/FEB/2016 

  
	
  51237A 

  	
   

  	
  US 

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  07/JUN/2015 

  
	
  51246A 

  	
   

  	
  CA 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/NOV/2016 

  
	
  51246A 

  	
   

  	
  JP 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/NOV/2016 

  
	
  51246A 

  	
   

  	
  NO 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/NOV/2016 

  
	
  51246A 

  	
   

  	
  US 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/NOV/2016 

  
	
  51246A 

  	
   

  	
  WO 

  	
   

  	
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  51263A 

  	
   

  	
  EP 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/APR/2016 

  
	
  51282A 

  	
   

  	
  AU 

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A 

  	
   

  	
  AU 

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A 

  	
   

  	
  BG 

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016 

  
	
  51282A 

  	
   

  	
  BR 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016 

  
	
  51282A 

  	
   

  	
  BY 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016 

  
	
  51282A 

  	
   

  	
  CA 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016 

  
	
  51282A 

  	
   

  	
  CN 

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  20/JUN/2016 

  
	
  51282A 

  	
   

  	
  CN 

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016 

  
	
  51282A 

  	
   

  	
  CZ 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016 

  
	
  51282A 

  	
   

  	
  DE 

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  04/JUL/2015 

  
	
  51282A 

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016 

  
	
  51282A 

  	
   

  	
  HK 

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  20/JUN/2016 

  
	
  51282A 

  	
   

  	
  IL 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016 

  
	
  51282A 

  	
   

  	
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  20/JUN/2016 

  
	
  51282A 

  	
   

  	
  KR 

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  20/JUN/2016 

  
	
  51282A 

  	
   

  	
  MX 

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016 

  



 


47

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51282A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  PK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/FEB/2018

  
	
  51282A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  RU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/SEP/2011

  
	
  51282A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
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  03/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
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  03/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/JUL/2016

  
	
  51282A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51282A

  	
   

  	
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  04/JUL/2010

  
	
  51282A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2016

  
	
  51282A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
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  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
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  51282A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  PT

  	
   

  	
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  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
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  [*****]

  	
   

  	
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  20/JUN/2016

  
	
  51282A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
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  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51285A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2016

  
	
  51285A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
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48

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51285A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/FEB/2017

  
	
  51285A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/DEC/1997

  
	
  51285A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51285A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51315A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JAN/2016

  
	
  51315A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  BR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  



 


49

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51322A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JAN/2016

  
	
  51322A

  	
   

  	
  EE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  IS

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  PK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/FEB/2018

  
	
  51322A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  RU

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/JAN/2012

  
	
  51322A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  17/JAN/2017

  
	
  51322A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/JAN/2017

  
	
  51322A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/JAN/2017

  
	
  51322A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/JAN/2017

  
	
  51322A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/FEB/1997

  
	
  51322A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51322A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  17/JAN/2017

  
	
  51322A

  	
   

  	
  LV

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  LT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  RO

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51358A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  



 


50

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51358A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  22/DEC/2015

  
	
  51358A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  RU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  20/DEC/2011

  
	
  51358A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51358A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/JAN/1997

  
	
  51358A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51358A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51358A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51358A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51358A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  LI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51378A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  26/SEP/2017

  
	
  51378A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/SEP/2018

  
	
  51378A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/OCT/1998

  



 


51

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51378A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51378A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  CY

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51412B

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  BA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  BR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  MK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  RO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  SI

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  SK2

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  TR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51412B

  	
   

  	
  YU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  



 


52

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51412B

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51433A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/AUG/2017

  
	
  51433A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2007

  
	
  51433A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  TH

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  04/AUG/2017

  
	
  51433A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/AUG/2012

  
	
  51433A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/AUG/2017

  
	
  51433A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51433A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/AUG/2017

  
	
  51433A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  01/AUG/2017

  
	
  51437A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  04/DEC/2016

  
	
  51437A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  



 


53

















 


	
  File number

  	
   

  	
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  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51437A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/NOV/2017

  
	
  51437A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2017

  
	
  51437A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51437A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2017

  
	
  51457A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  04/DEC/2016

  
	
  51457A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51457A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51457A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/NOV/2017

  
	
  51457A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/NOV/2017

  
	
  51457A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2017

  
	
  51457A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51457A

  	
   

  	
  ZA

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  04/DEC/2017

  
	
  51479A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/JUL/1998

  
	
  51502A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  03/JUL/2017

  
	
  51502A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  28/MAY/2018

  
	
  51502A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2018

  
	
  51502A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  02/JUL/2013

  
	
  51502A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUN/2018

  
	
  51502A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/JUN/2018

  
	
  51502A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/1998

  
	
  51502A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51502A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/JUL/2018

  
	
  51502A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/OCT/2022

  
	
  51519A

  	
   

  	
  KP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/SEP/2013

  
	
  51521A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  10/MAR/2020

  
	
  51521A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  22/FEB/2021

  
	
  51521A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  08/MAR/2021

  
	
  51521A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/SEP/2001

  
	
  51521A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51521A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  22/FEB/2021

  
	
  51521A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  22/FEB/2021

  
	
  51538A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  24/SEP/2018

  
	
  51538A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51538A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/SEP/2017

  
	
  51538A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51538A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51538A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51538A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/SEP/2018

  
	
  51538A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/OCT/1998

  
	
  51538A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51545A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/MAR/2019

  
	
  51545A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  



 


54

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51545A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2014

  
	
  51545A

  	
   

  	
  JP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/MAR/2020

  
	
  51545A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/APR/2000

  
	
  51545A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51545A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51547A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/DEC/2017

  
	
  51547A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/DEC/2018

  
	
  51547A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/DEC/2018

  
	
  51547A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/DEC/2018

  
	
  51547A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  07/JAN/1999

  
	
  51547A

  	
   

  	
  WO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51549A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51562A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/1999

  
	
  51562A

  	
   

  	
  WO

  	
   

  	
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  51563A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/1999

  
	
  51563A

  	
   

  	
  WO

  	
   

  	
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  51564A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51590A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  03/APR/2018

  
	
  51613A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  24/JUL/2018

  
	
  51613A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/JUL/2019

  
	
  51613A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/JUL/2019

  
	
  51613A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/JUL/2019

  
	
  51613A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  02/JUL/2014

  
	
  51613A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  23/JUL/2019

  
	
  51613A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  30/OCT/1999

  
	
  51613A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51614A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/SEP/2018

  
	
  51614A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/SEP/2019

  
	
  51614A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/NOV/1999

  
	
  51614A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51614A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
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  20/AUG/2019

  



 


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  Expiry

  
	
  51614A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  CY

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51645A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  A17/NOV/2019

  
	
  51645A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2018

  
	
  51645A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/DEC/2019

  
	
  51645A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/JAN/2000

  
	
  51645A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51645A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  17/NOV/2019

  
	
  51658A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/SEP/2018

  
	
  51669A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/SEP/2019

  
	
  51669A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  28/SEP/2020

  
	
  51669A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/SEP/2020

  
	
  51669A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/OCT/2000

  
	
  51684A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51729A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/SEP/2019

  
	
  51729A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  28/SEP/2020

  
	
  51729A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/SEP/2020

  
	
  51729A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/OCT/2000

  
	
  51729A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  12/JUL/2022

  
	
  51734A

  	
   

  	
  PE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734A

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51734A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JUL/2021

  
	
  51734A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734A

  	
   

  	
  UY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/JUL/2022

  
	
  51734A

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51734A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51734B

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734B

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51734B

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JUL/2021

  
	
  51734B

  	
   

  	
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  19/JUL/2022

  



 


56

















 


	
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  Expiry

  
	
  51734B

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734B

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51734B

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51734B

  	
   

  	
  UY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/JUL/2022

  
	
  51734B

  	
   

  	
  PE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51735A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/OCT/2000

  
	
  51752A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  06/AUG/2019

  
	
  51752A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  25/JUL/2020

  
	
  51752A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  25/JUL/2020

  
	
  51752A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/AUG/2020

  
	
  51752A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/AUG/2000

  
	
  51752A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51760A

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  11/AUG/2020

  
	
  51760A

  	
   

  	
  PH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51760A

  	
   

  	
  TH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51760A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2016

  
	
  51760A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51760A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/SEP/2001

  
	
  51760A

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  HR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  YU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  HK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  EE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  BR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2015

  
	
  51760A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  CO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  



 


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  Grant number

  	
   

  	
  Expiry

  
	
  51761A

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  BR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  HR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51761A

  	
   

  	
  EE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
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  51761A

  	
   

  	
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  51761A

  	
   

  	
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  51761A

  	
   

  	
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  23/JUL/2021

  
	
  51761A

  	
   

  	
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  [*****]

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
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  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
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  10/AUG/2021

  
	
  51761A

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51761A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
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  11/AUG/2020

  
	
  51761A

  	
   

  	
  PH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
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  10/AUG/2021

  
	
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  26/SEP/2001

  
	
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  51761A

  	
   

  	
  WO

  	
   

  	
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  51762A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51762A

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51762A

  	
   

  	
  DE

  	
   

  	
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  11/AUG/2020

  
	
  51762A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2016

  
	
  51762A

  	
   

  	
  US

  	
   

  	
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  10/AUG/2021

  
	
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  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/SEP/2001

  
	
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  51762A

  	
   

  	
  WO

  	
   

  	
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  51762A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
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  23/JUL/2021

  
	
  51762A

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  CO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
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58

















 


	
  File number

  	
   

  	
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  Grant number

  	
   

  	
  Expiry

  
	
  51762A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
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  23/JUL/2021

  
	
  51762A

  	
   

  	
  EP

  	
   

  	
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  23/JUL/2021

  
	
  51762A

  	
   

  	
  YU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
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  06/SEP/2015

  
	
  51766A

  	
   

  	
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  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
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  BR

  	
   

  	
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  06/SEP/2020

  
	
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  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
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  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
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  51766A

  	
   

  	
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  09/SEP/2019

  
	
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  51766A

  	
   

  	
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  09/SEP/2019

  
	
  51766A

  	
   

  	
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  51766A

  	
   

  	
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  06/SEP/2020

  
	
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  09/SEP/2019

  
	
  51766A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
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  ID

  	
   

  	
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  06/SEP/2020

  
	
  51766A

  	
   

  	
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  09/SEP/2019

  
	
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  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
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  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2014

  
	
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  JP

  	
   

  	
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  06/SEP/2020

  



 


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  Expiry

  
	
  51766A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
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  09/SEP/2019

  
	
  51766A

  	
   

  	
  MC

  	
   

  	
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  51766A

  	
   

  	
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  09/SEP/2019

  
	
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  06/SEP/2020

  
	
  51766A

  	
   

  	
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  [*****]

  	
   

  	
  09/SEP/2019

  
	
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  06/SEP/2020

  
	
  51766A

  	
   

  	
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  [*****]

  	
   

  	
  09/SEP/2019

  
	
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  SK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/SEP/2015

  
	
  51766A

  	
   

  	
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  06/SEP/2020

  
	
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  15/SEP/2019

  
	
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  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  11/SEP/2020

  
	
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  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51766A

  	
   

  	
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  51766A

  	
   

  	
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  06/SEP/2020

  
	
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  06/SEP/2020

  
	
  51766A

  	
   

  	
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  11/SEP/2020

  
	
  51768A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2022

  
	
  51768A

  	
   

  	
  DE

  	
   

  	
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  [*****]

  	
   

  	
  26/JAN/2021

  
	
  51768A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/JAN/2022

  
	
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  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  13/FEB/2002

  
	
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  51769A

  	
   

  	
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  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  24/APR/2002

  
	
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  18/MAR/2017

  
	
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  15/OCT/2019

  
	
  51800A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
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  13/JAN/2020

  
	
  51800A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  27/JAN/2001

  
	
  51800A

  	
   

  	
  WO

  	
   

  	
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  51832A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/DEC/2022

  
	
  51834A

  	
   

  	
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  05/DEC/2021

  
	
  51834A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  14/DEC/2021

  
	
  51834A

  	
   

  	
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  51834A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  15/DEC/2020

  
	
  51834A

  	
   

  	
  JO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  02/JUL/2022

  
	
  51834A

  	
   

  	
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  13/DEC/2021

  
	
  51834A

  	
   

  	
  SA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51834A

  	
   

  	
  TH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  14/DEC/2021

  
	
  51834A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  07/NOV/2016

  
	
  51834A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  13/DEC/2021

  
	
  51834A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/DEC/2001

  
	
  51834A

  	
   

  	
  UY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/DEC/2021

  
	
  51834A

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51834A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51954A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/SEP/2020

  



 


60

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51954A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  14/SEP/2016

  
	
  51954A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  14/SEP/2021

  
	
  51954A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  27/SEP/2001

  
	
  51954A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51954A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/SEP/2021

  
	
  51954A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/SEP/2021

  
	
  51954A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/SEP/2021

  
	
  52024A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAR/2022

  
	
  52024A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52024A

  	
   

  	
  WO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/NOV/2022

  
	
  52024A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52162A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  18/JUN/2021

  
	
  52163A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2021

  
	
  52163A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2022

  
	
  52163A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  52164A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  11/JUL/2021

  
	
  52164A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  11/JUL/2022

  
	
  52164A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/JUL/2002

  
	
  52164A

  	
   

  	
  WO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52165A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2022

  
	
  52165A

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52165A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2021

  
	
  52165A

  	
   

  	
  PE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2022

  
	
  52165A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/JUL/2022

  
	
  52165A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  07/OCT/2022

  
	
  52165A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2002

  
	
  52165A

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52165A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  52165A

  	
   

  	
  UY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/JUN/2022

  
	
  52207A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  22/OCT/2002

  
	
  52231A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/APR/2023

  
	
  52231A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52307A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JUL/2003

  
	
  52307A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2022

  
	
  52308A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  13/DEC/2022

  
	
  52308A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  12/FEB/2004

  
	
  52309A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/FEB/2023

  
	
  52309A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/MAR/2004

  
	
  52335A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/APR/2023

  
	
  52335A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  11/APR/2004

  
	
  53061A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/FEB/2023

  
	
  53061A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  12/FEB/2004

  
	
  53063A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/APR/2023

  
	
  53063A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  53072A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/FEB/2023

  
	
  53072A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  12/FEB/2004

  



 


61

















 


Exhibit 2.1


 


Proof of Concept Study – Deliverables


 


Scope


 


•                  Schering AG
wants to have delivered data of a [*****] to [*****] of EP-2104R


•                  This means:


•                  Data on [*****]
of EP-2104R in [*****]


•                  Data on imaging
[*****] for [*****] of [*****] and [*****] as well as [*****] in [*****]


 


Imaging topics to be
addressed include


•                  Demonstration of
[*****] of [*****] and [*****]


•                  Delineation of
[*****] and [*****]


•                  Delineation of
[*****] (if available from study data)


•                  Detection
[*****] (evaluation of [*****], [*****])


•                  [*****]


 


Study Details


 


•                  [*****] in
[*****] at [*****] up to [*****]; [*****] x ([*****]) = [*****]


•                  MRI of [*****]
or [*****] in [*****] at [*****] [*****], and at [*****] at [*****])


•                  Starting [*****]
MRI: start [*****] on [*****] and [*****], if [*****] considered [*****]


•                  Investigate
[*****] in [*****] [*****]


1.               [*****] patients


 


• [*****] with
[*****] or [*****]

•
in case of [*****] in the [*****], [*****] to [*****]


 


2.             [*****] patients
•
[*****] or [*****] of patients should be [*****]


 


[*****]
patients
•
[*****] or [*****] [*****] or [*****])

•- MR [*****]


 


•                  Evaluation of
[*****] and [*****], i.e.


•                  Depiction of
[*****] including assessment of [*****]investigate [*****] of [*****]


•                  Investigate
[*****]


•                  Measurement of
[*****]


 


62

















 


Exhibit 3.1


 


Epix Budget
Plan EP-2104R


 


	
   

  	
   

  	
  02

  	
   

  	
  03

  	
   

  	
  04

  	
   

  	
  2003

  	
   

  	
  01

  	
   

  	
  02

  	
   

  	
  03

  	
   

  	
  04

  	
   

  	
  2004

  	
   

  	
  01

  	
   

  	
  02

  	
   

  	
  03

  	
   

  	
  04

  	
   

  	
  2005

  	
   

  	
  Total

  	
   

  
	
  Task

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  
	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  
	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  
	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  
	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  
	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  
	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  
	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



 


63