exv4w38



 


Exhibit 4.38



Confidential treatment has been requested for certain portions of
this exhibit. The copy filed herewith omits the information subject
to the confidential treatment request. Omissions are designated as
“[*****]” or “*****”. A complete
version of this exhibit has been filed separately with the Commission
pursuant to an application for confidential treatment under
Rule 24b-2 promulgated under the Securities Exchange Act of
1934, as amended.



ACAMBIS SUBCONTRACT MODIFICATION



Subcontract Number: 200-2002-00012(CBL) (PO 28890)



Modification Number: 0004



Effective Date: This Subcontract modification is effective as of the last
signed date below.




	 	 	 	 	 
	Subcontractor:	 	
Chesapeake Biological Laboratories, Inc.
	 	 
	 	 	
1111 S. Paca Street	 	 
	 	 	
Baltimore, MD 21230-2591	 	 



Authority for, and type of, modification: Bilateral Supplemental Agreement


Description of Modification:



	 	 	 
	Clause B.9	 	
Adds Item 0009AA for CBL to perform first iteration of Acambis’s [****]
Shipping Validation (Lyophilized ACAM 2000) Sections 9.1 and 9.2
	 	 	 
	 	 	
Adds Item 0009AB for CBL to perform second iteration of
Acambis’s [****] Shipping Validation (Lyophilized
ACAM 2000) Sections 9.1 and 9.2 (if ordered)
	 	 	 
	 	 	
Adds Item 0009AC for CBL to perform third iteration of
Acambis’s [****] Shipping Validation (Lyophilized
ACAM 2000) Sections 9.1 and 9.2 (if ordered)
	 	 	 
	Clause F.1	 	
Adds delivery dates for the documentation generated by
Manufacturing Items 0009AA, 0009AB, and 0009AC
	 	 	 
	Clause G.1	 	
Modifies payment clause to address invoicing for Item 0009
	 	 	 
	Clause G.2	 	
Modifies delivery order provision to add Items 0009AB and 0009AC
	 	 	 
	Clause I.2	 	
Modifies clause to add Items 0009AB and 0009AC
	 	 	 
	Clause I.4	 	
Modifies clause to add Items 0009AB and 0009AC



Once validation of the shipping procedure described in “Shipping Validation:
Lyophilized ACAM 2000” (Protocol US02-VQP-107) is complete, CBL shall follow
that validated process in performing its responsibilities under the Statement
of Work for Subcontract 200-2002-00012(CBL).



Total Change to Subcontract Amount:



	 	 	 	 	 	 	 	 	 
	 	 	
Item 0009AA
	 	[****]	 	[****]
	 	 	
Item 0009AB
	 	[****]	 	[****] (if ordered)
	 	 	
Item 0009AC
	 	[****]	 	[****] (if ordered)



 







 



ACAMBIS CONFIDENTIAL — PROPRIETARY INFORMATION




Modification 0004




Changes to Subcontract:





	 	(a)	 	See attached Pages 3-4




RELEASE OF CLAIMS



In consideration of the modifications made herein, this Modification is in full
settlement of any right the Subcontractor may have to any equitable
adjustment(s) as the result of the changes herein. Except to the extent
modified herein, the subcontract terms and conditions remain unchanged. This
supplemental agreement constitutes the full agreement of the parties and
supercedes any prior agreements with respect to the changes made herein.




	 	 	 
	ACAMBIS, INC	 	
CHESAPEAKE BIOLOGICAL LABORATORIES, INC
	 	 	 
	 	 	 
	
	 	


	[****]	 	
[****]
	 	 	 
	March 4, 2003	 	
March 5, 2003



2







 



ACAMBIS CONFIDENTIAL — PROPRIETARY INFORMATION




Modification 0004




Section B





	1.	 	Add Items 0009A, 0009B, 0009C
	 
	B.	 	9 SUBCONTRACT LINE ITEM 0009
	 
	 	 	Shipping Validation




	 	 	 
	Item 0009AA	 	Total Amount
	
	 	

	Perform 1st iteration of Acambis’s	 	
[****]
	[****] Shipping Validation	 	
 
	(Lyophilized ACAM 2000)	 	 
	Sections 9.1 and 9.2 (attached)	 	 




	 	 	 	 	 	 	 
	 	 	 	 	Estimated	 	Estimated
	Item 0009AB	 	Firm Fixed Price	 	Quantity	 	Total Amount
	
	 	
	 	
	 	

	Perform 2nd iteration of Acambis’s	 	
[****]
	 	1 (as ordered)
	 	[****]
	[****] Shipping Validation	 	 	 	 	 	 
	(Lyophilized ACAM 2000)	 	 	 	 	 	 
	Sections 9.1 and 9.2 (attached)	 	 	 	 	 	 





	 	(a)	 	See Section G.2 for ordering provisions




	 	 	 	 	 	 	 
	 	 	 	 	Estimated	 	Estimated
	Item 0009AC	 	Firm Fixed Price	 	Quantity	 	Total Amount
	
	 	
	 	
	 	

	Perform 3rd iteration of Acambis’s	 	
[****]
	 	1 (as ordered)
	 	[****]
	[****] Shipping Validation	 	 	 	 	 	 
	(Lyophilized ACAM 2000)	 	 	 	 	 	 
	Sections 9.1 and 9.2 (attached)	 	 	 	 	 	 





	 	(a)	 	See Section G.2 for ordering provisions




Section F





	1.	 	Add provision F.2(10)




	 	 	 	 	 
	No.	 	Description	 	Delivery Date
	10	 	
Documentation generated in performance of
Items 0009AA, 0009AB (if ordered), and
0009AC (if ordered)
	 	7 calendar days after
completion of performance
of responsibilities under
Sections 9.1 and 9.2
of the Shipping Validation Protocol



3







 



ACAMBIS CONFIDENTIAL — PROPRIETARY INFORMATION




Modification 0004




Section G





	1.	 	Add to provision G.1





	 	(3)(a)	 	 Manufacturer may invoice for Items 0009AA, 0009AB, and 0009AC after
completing each Item, including submitting the documentation required
by Section F.2(10).





	2.	 	Delete provision G.2(a), G.2(b)(2)
	 
	 	 	Add provision G.2(a)





	 	(a)	 	Orders may be issued against Contract Line Items 0004A, 0004B,
0005A, 0005B and 0006 to fill and finish vaccine and/or diluent;
Items 0003A, 0003B, and 0005B to change over the manufacturing
facility; and Items 0009AB and 0009AC to perform portions of shipping
validation at the price(s) set forth in the Subcontract Schedule
(Section B).





	 	 	Add provision G.2(b)(2)





	 	(b)(2)	 	 The Contract Line Item (0003A, 0003B, 0004A, 0004B, 0005A, 0005B,
0006, 0009AB, or 0009AC) against which the order is being placed;





	3.	 	Add to provision G.2(e)
	 
	 	 	ITEMS 0009AB and 0009AC – There is no minimum guaranteed quantity.




Section I





	1.	 	Delete provision I.2 heading “FAR 52.216-18 ORDERING (OCT 1995)
(MODIFICATION) (Items 0003A, 0003B, 0004A, 0004B, 0005A, 0005B, and 0006)”
	 
	 	 	Add provision I.2 heading “FAR 52.216-18 ORDERING (OCT 1995)
(MODIFICATION) (Items 0003A, 0003B, 0004A, 0004B, 0005A, 0005B, 0006,
0009AB, and 0009AC)”
	 
	2.	 	Delete provision I.4 heading “FAR 52.216-22 INDEFINITE QUANTITY (OCT
1995) (Modification) (Items 0003A, 0003B, 0004A, 0004B, 0005A, 0005B, and
0006)”
	 
	 	 	Add provision I.4 heading “FAR 52.216-22 INDEFINITE QUANTITY (OCT 1995)
(Modification) (Items 0003A, 0003B, 0004A, 0004B, 0005A, 0005B, 0006,
0009AB, and 0009AC)”





4