EX-10.3



 Exhibit 10.3 

ASSIGNMENT AND ASSUMPTION OF LEASE 

THIS ASSIGNMENT AND ASSUMPTION OF LEASE (the “Assignment”) is entered into as of the 30th day of September, 2016, by and between BLUEBIRD BIO, INC., a Delaware corporation (“Assignor”), and FOUNDATION MEDICINE, INC., a Delaware corporation (“Assignee”).

 A. Assignor, as Tenant, and ARE-MA Region No. 50, LLC, a Delaware limited liability company, as successor to 150 Second Street, LLC, as
Landlord (“Landlord”), are parties to that certain Lease Agreement dated as of June 3, 2013, as amended by a First Amendment to Lease dated November 15, 2013 and a Second Amendment to Lease dated June 9, 2014 (as so amended, the
“Lease”), with respect to certain premises consisting of approximately 53,455 rentable square feet and the Shared Space (as such term is defined in the Lease) allocated to Assignor for Assignor’s mechanical, PH and lab-related
storage located in the penthouse, first floor and lower level of the Building (collectively, the “Demised Premises”) in the building located at 150 Second Street, Cambridge, Massachusetts; and 

B. Assignor desires to assign to Assignee its interest under the Lease, and Assignee desires to assume all of the rights and obligations of
Assignee under the Lease as of the Effective Date (as such term is defined below). 
 NOW, THEREFORE, in consideration of $1.00 and other
good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Assignor and Assignee hereby agree as set forth herein. 

1. Assignor does hereby assign all of its rights, interests, obligations and responsibilities in and under the Lease to Assignee, effective as
of the later of (a) 12:01 AM on May 1, 2017, or (b) 12:01 AM on the first day following the date on which Assignor yields up and surrenders the Demised Premises and possession thereof as required under Article 20 of the Lease (the “Effective
Date”), which assignment shall be upon the conditions set forth in this Assignment, and conditioned upon the Landlord under the Lease entering into a Consent to Assignment with Assignor and Assignee in the form attached hereto as Exhibit
A (the “Consent”). Notwithstanding anything to the contrary contained in this Assignment, if Assignor has not yielded up and surrendered the Demised Premises and possession thereof as required under Article 20 of the Lease
(the “Yield Up”) before January 31, 2018, then, unless such failure is due to a Force Majeure Stay (as defined below) and Assignor is then meeting the Force Majeure Stay Conditions (as defined below), Assignee shall have the right
to terminate and cancel this Assignment by written notice to Assignor given prior to the Yield Up, and upon the sending of such notice prior to the Yield Up, this Assignment shall be terminated and cancelled. Assignee shall deliver a copy of
such notice to Landlord at the same time that Assignee sends such notice to Assignor. Notwithstanding the foregoing, Assignee shall not have the right to terminate this Assignment for 3 months after the date of any Force Majeure Stay Notice (as
defined below), if the following conditions (the “Force Majeure Stay Conditions”) are met: (i) the delay of the Yield Up directly results from events beyond the reasonable control of Assignor (a “Force Majeure
Stay”), (ii) Assignor has given Assignee written notice of such Force Majeure Stay (a “Force Majeure Stay Notice”), and (iii) Assignor demonstrates to Assignee’s reasonable satisfaction that, within such 3-month
period, Assignor or its landlord at the premises to which Assignor plans to relocate, as applicable, is making good faith efforts to remediate the effects of the events giving rise to the Force Majeure Stay. 







 2. Assignee hereby accepts this Assignment as of the Effective Date upon the conditions set forth
in this Assignment and conditioned upon the Landlord under the Lease entering into the Consent. Assignee shall observe and perform and be bound by all of the terms, covenants and conditions of the Lease as tenant thereunder first arising and
accruing from and after the Effective Date. 
 3. Assignee shall indemnify and hold harmless Assignor for, from and against any actions,
suits, proceedings or claims, and all costs and expenses, including, without limitation, reasonable attorneys’ fees, incurred in connection therewith, based upon or arising out of any breach or alleged breach of the Lease occurring or alleged
to have occurred from and after the Effective Date or resulting from facts, circumstances or events first arising or occurring from and after the Effective Date, and not due to the acts or omissions of Assignor.

4. Assignor shall indemnify and hold harmless Assignee for, from and against any actions, suits, proceedings or claims, and all costs and
expenses, including, without limitation, reasonable attorneys’ fees, incurred in connection therewith, based upon or arising out of any breach or alleged breach of the Lease occurring or alleged to have occurred before the Effective Date or
resulting from facts, circumstances or events occurring or alleged to have occurred before the Effective Date. 
 5. Assignor hereby
represents, warrants and covenants to Assignee, as of the date hereof, as follows: 
  

	 	(a)	There have been no amendments to the Lease other than those recited in paragraph A above, and a true, correct and complete copy of the Lease is attached hereto as Exhibit B; 


 

	 	(b)	Assignor has not assigned all or any of its interests under the Lease; 

  

	 	(c)	Assignor has not entered into any sublease of any space demised by the Lease; 

  

	 	(d)	There is no Default (as such term is defined in the Lease) or, to Assignor’s knowledge, set of circumstances or conditions that with notice or the passage of time or both would become a Default under the Lease; and


  

	 	(e)	Assignor covenants that it will not take, or fail to take, any action to cause or permit any of the above representations and warranties to become untrue prior to the Effective Date, and such representations and
warranties shall be deemed to have been re-made as of the Effective Date.

 6. All notices or other communications between the
parties shall be in writing and shall be deemed duly given upon delivery or refusal to accept delivery by the addressee thereof if delivered in person, or upon actual receipt if delivered by reputable overnight guaranty courier, addressed and sent
to the parties at their addresses set forth below. Assignor and Assignee may from time to time by written notice to the other designate another address for receipt of future notices. 

  
 2 








 Assignor’s Address: 

Prior to the Effective Date: 

bluebird bio, Inc. 
 150 Second
Street – First Floor 
 Cambridge, MA 02141

Attention: General Counsel 

After the Effective Date: 

bluebird bio, Inc. 
 60 Binney
Street 
 Cambridge, MA 02142 

Attention: General Counsel 
 Assignee’s
Address: 
 Foundation Medicine, Inc. 

150 Second Street 
 Cambridge,
MA 02141
 Attention: General Counsel 

7. This Assignment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken
together shall constitute one and the same instrument. 
 8. If a suit, action, arbitration or other proceeding of any nature whatsoever (an
“Action”) is instituted in connection with any controversy arising out of this Assignment or to interpret or enforce any rights under this Assignment, the prevailing party shall be entitled to recover reasonable costs and expenses
incurred in connection with such Action, including without limitation, reasonable attorneys’ fees and court costs incurred by the prevailing party. 

9. This Assignment is binding upon and shall inure to the benefit of the parties hereto and their respective permitted successors and assigns.

 10. Construction and interpretation of this Assignment shall be governed by the internal laws of the Commonwealth of Massachusetts,
excluding any principles of conflicts of laws. 
 [remainder of page intentionally left blank] 

  
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 Executed as an instrument under seal as of the date first written above. 

 

					
	 ASSIGNOR

	
	 bluebird bio, Inc.,

	 a Delaware corporation

		
	 By:  
	 	 /s/ Jason F. Cole

		 	 Name:
	 	 Jason F. Cole

		 	 Title:
	 	 Chief Legal Officer

	
	 ASSIGNEE

	
	 Foundation Medicine, Inc.,

	 a Delaware corporation

		
	 By:
	 	 /s/ Steven Kafka

		 	 Name:
	 	 Steven Kafka

		 	 Title:
	 	 President and Chief Operating Officer




  
 4 








 Exhibit A 

Form of Consent 

(incorporated by reference to Exhibit 10.2 of the Company’s Current Report on Form 8-K, filed
with the SEC on October 5, 2016) 







 Exhibit B 

Copy of Lease 

(attached) 







 LEASE 

Between 
 150 SECOND
STREET, LLC 
 as Landlord, 

and 
 BLUEBIRD BIO, INC.

 as Tenant, 

For Premises located at: 

150 Second Street 

Cambridge, Massachusetts 







 TABLE OF CONTENTS 

 

					
	 ARTICLE 1 BASIC LEASE PROVISIONS; DEFINITIONS
	  	 	1	  
	 1.1 Basic Lease Provisions
	  	 	1	  
	 1.2 Definitions
	  	 	5	  
		
	 ARTICLE 2 PREMISES; APPURTENANT RIGHTS; RESERVATIONS
	  	 	8	  
	 2.1 Lease of Premises
	  	 	8	  
	 2.2 Appurtenant Rights
	  	 	9	  
	 2.3 Landlord Reservations
	  	 	10	  
		
	 ARTICLE 3 DELIVERY OF PREMISES; ACCEPTANCE
	  	 	10	  
	 3.1 Delivery of Premises; Acceptance of Premises
	  	 	10	  
	 3.2 Acknowledgment of Lease Commencement Date
	  	 	10	  
		
	 ARTICLE 4 RENT
	  	 	11	  
	 4.1 Base Rent
	  	 	11	  
	 4.2 Base Rent Abatement Period
	  	 	11	  
	 4.3 Additional Rent
	  	 	13	  
	 4.4 Intentionally Omitted
	  	 	14	  
	 4.5 Operating Expense Payments
	  	 	14	  
	 4.6 Taxes
	  	 	17	  
		
	 ARTICLE 5 CONDITION OF PREMISES; CONSTRUCTION
	  	 	18	  
	 5.1 Base Building Work
	  	 	18	  
	 5.2 Tenant’s Work
	  	 	18	  
	 5.3 Intentionally Deleted
	  	 	20	  
	 5.4 Landlord’s Contribution
	  	 	20	  
		
	 ARTICLE 6 USE
	  	 	22	  
	 6.1 Use
	  	 	22	  
		
	 ARTICLE 7 PARKING
	  	 	22	  
	 7.1 Parking
	  	 	22	  
		
	 ARTICLE 8 UTILITIES; SERVICES
	  	 	24	  
	 8.1 Utilities; Services
	  	 	24	  
	 8.2 Shafts and Risers
	  	 	24	  
	 8.3 Rooftop Premises
	  	 	25	  
	 8.4 Access
	  	 	26	  
		
	 ARTICLE 9 ALTERATIONS
	  	 	26	  
	 9.1 Alterations and Tenant’s Property
	  	 	26	  
		
	 ARTICLE 10 REPAIRS AND MAINTENANCE
	  	 	28	  
	 10.1 Landlord’s Repairs
	  	 	28	  
	 10.2 Tenant’s Repairs
	  	 	29	  


  
 i 









					
	 ARTICLE 11 MECHANIC’S LIENS
	  	 	29	  
	 11.1 Mechanic’s Liens
	  	 	29	  
		
	 ARTICLE 12 INDEMNIFICATION
	  	 	30	  
	 12.1 Indemnification
	  	 	30	  
		
	 ARTICLE 13 INSURANCE
	  	 	30	  
	 13.1 Insurance
	  	 	30	  
		
	 ARTICLE 14 RESTORATION
	  	 	32	  
	 14.1 Restoration
	  	 	32	  
		
	 ARTICLE 15 CONDEMNATION
	  	 	33	  
	 15.1 Condemnation
	  	 	33	  
		
	 ARTICLE 16 EVENTS OF DEFAULT
	  	 	34	  
	 16.1 Events of Default
	  	 	34	  
	 16.2 Landlord’s Remedies
	  	 	35	  
		
	 ARTICLE 17 ASSIGNMENT AND SUBLETTING
	  	 	37	  
	 17.1 General Prohibition
	  	 	37	  
	 17.2 Permitted Transfers
	  	 	37	  
	 17.3 Additional Conditions
	  	 	39	  
	 17.4 No Release of Tenant, Sharing of Excess Rents
	  	 	40	  
	 17.5 No Waiver
	  	 	40	  
	 17.6 Prior Conduct of Proposed Transferee
	  	 	40	  
		
	 ARTICLE 18 ESTOPPEL CERTIFICATE
	  	 	40	  
	 18.1 Estoppel Certificate
	  	 	40	  
		
	 ARTICLE 19 SUBORDINATION
	  	 	41	  
	 19.1 Subordination
	  	 	41	  
		
	 ARTICLE 20 SURRENDER
	  	 	41	  
	 20.1 Surrender
	  	 	41	  
		
	 ARTICLE 21 ENVIRONMENTAL REQUIREMENTS
	  	 	43	  
	 21.1 Prohibition/Compliance/Indemnity
	  	 	43	  
	 21.2 Business
	  	 	44	  
	 21.3 Tenant Representation and Warranty
	  	 	44	  
	 21.4 Testing
	  	 	44	  
	 21.5 Control Areas
	  	 	45	  
	 21.6 Intentionally Deleted
	  	 	45	  
	 21.7 Tenant’s Obligations
	  	 	45	  
	 21.8 Definitions
	  	 	45	  
		
	 ARTICLE 22 TENANT’S REMEDIES/LIMITATION OF LIABILITY
	  	 	46	  
	 22.1 Tenant’s Remedies/Limitation of Liability
	  	 	46	  
	 22.2 Limitation on Landlord’s Liability
	  	 	46	  


  
 ii 









					
	 ARTICLE 23 INSPECTION AND ACCESS
	  	 	47	  
	 23.1 Inspection and Access
	  	 	47	  
		
	 ARTICLE 24 SIGNAGE
	  	 	48	  
	 24.1 Signs; Exterior Appearance
	  	 	48	  
		
	 ARTICLE 25 HOLDING OVER
	  	 	48	  
	 25.1 Holding Over
	  	 	48	  
		
	 ARTICLE 26 WAIVER OF JURY TRIAL
	  	 	49	  
	 26.1 Waiver of Jury Trial
	  	 	49	  
		
	 ARTICLE 27 SECURITY DEPOSIT
	  	 	49	  
	 27.1 Security Deposit
	  	 	49	  
		
	 ARTICLE 28 RIGHT TO EXTEND TERM
	  	 	50	  
	 28.1 Extension Rights
	  	 	50	  
	 28.2 Arbitration
	  	 	51	  
	 28.3 Rights Personal
	  	 	51	  
	 28.4 Exceptions
	  	 	52	  
	 28.5 No Extensions
	  	 	52	  
	 28.6 Termination
	  	 	52	  
		
	 ARTICLE 29 RIGHT OF FIRST OFFER
	  	 	52	  
	 29.1 Tenant’s Right of First Offer
	  	 	52	  
		
	 ARTICLE 30 MISCELLANEOUS
	  	 	53	  
	 30.1 Notices
	  	 	53	  
	 30.2 Joint and Several Liability
	  	 	53	  
	 30.3 Financial Information
	  	 	53	  
	 30.4 Recordation
	  	 	54	  
	 30.5 Interpretation
	  	 	54	  
	 30.6 Not Binding Until Executed
	  	 	54	  
	 30.7 Limitations on Interest
	  	 	54	  
	 30.8 Choice of Law
	  	 	54	  
	 30.9 Time
	  	 	54	  
	 30.10 OFAC
	  	 	55	  
	 30.11 Incorporation by Reference
	  	 	55	  
	 30.12 Entire Agreement
	  	 	55	  
	 30.13 No Accord and Satisfaction
	  	 	55	  
	 30.14 Hazardous Activities
	  	 	55	  
	 30.15 REIT/UBTI
	  	 	55	  
	 30.16 Quiet Enjoyment
	  	 	56	  
	 30.17 Prorations
	  	 	56	  
	 30.18 Rules and Regulations
	  	 	56	  
	 30.19 Security
	  	 	56	  
	 30.20 Force Majeure
	  	 	57	  
	 30.21 Brokers
	  	 	57	  
	 30.22 Severability
	  	 	57	  


  
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 LEASE AGREEMENT 

THIS LEASE AGREEMENT (this “Lease”) is made as of the 3 rd day of June, 2013 (“Effective
Date”), between 150 SECOND STREET, LLC, a Delaware limited liability company (“Landlord”), and BLUEBIRD BIO, INC., a Delaware corporation (“Tenant”). 

ARTICLE 1 
 BASIC
LEASE PROVISIONS; DEFINITIONS 
 1.1 Basic Lease Provisions. 

 

			
	Landlord:	  	150 Second Street, LLC, a Delaware limited liability company
		
	Landlord’s Address:	  	 c/o Skanska USA Commercial Development Inc.

253 Summer Street
 Boston, MA 02210

Attn: Charles Leatherbee

		
	Tenant:	  	Bluebird Bio, Inc., a Delaware corporation
		
	Tenant’s Original Address:	  	840 Memorial Drive Cambridge, MA 02139
		
	Address:	  	150 Second Street, Cambridge, Massachusetts
		
	Premises:	  	That portion of the Project known as Suite 300, containing 43,586 rentable square feet, comprising the entire third floor of the Building, including the Shared Space allocated to Tenant for Tenant’s mechanical, PH and lab
related storage located in the penthouse, first floor and lower level of the Building as shown on Exhibit A.
		
	Project:	  	The real property on which the building (the “Building”) in which the Premises are located at 150 Second Street, Cambridge, Massachusetts, together with all improvements thereon and appurtenances thereto
as described on Exhibit B.









			
	Base Rent:	  	$57.50 per rentable square foot of the Premises per annum with annual escalations as set forth in the following table:

  

													
	 Period
	 	Rate per RSF	 	 	Annual Base Rent	 	 	Monthly Base
Rent	 
	 Months 1(from Lease Commencement Date) through 12*
	 	$	57.50	  	 	$	2,506,195.00	  	 	$	208,849.58	  
	 Months 13 through 24*
	 	$	59.23	  	 	$	2,581,598.78	  	 	$	215,133.23	  
	 Months 25 through 36
	 	$	61.00	  	 	$	2,658,746.00	  	 	$	221,562.17	  
	 Months 37 through 48
	 	$	62.83	  	 	$	2,738,508.38	  	 	$	228,209.03	  
	 Months 49 through 60
	 	$	64.72	  	 	$	2,820,885.92	  	 	$	235,073.83	  
	 Months 61 through 72
	 	$	66.66	  	 	$	2,905,442.76	  	 	$	242,120.23	  
	 Months 73 through 84
	 	$	68.66	  	 	$	2,992,614.76	  	 	$	249,384.56	  
	 Months 85 through 96
	 	$	70.72	  	 	$	3,082,401.92	  	 	$	256,866.83	  
	 Months 97 through 108
	 	$	72.84	  	 	$	3,174,804.24	  	 	$	264,567.02	  

  

	*	Notwithstanding anything in this Section of the Lease to the contrary, Tenant shall be entitled to an abatement of Base Rent in the amount of $208,849.58 per month for six (6) consecutive full calendar months of
the Base Term beginning on the Lease Commencement Date, subject to the terms and conditions set forth in Section 4.2. 

  

			
	Rent Commencement Date:	  	The date following the Lease Commencement Date on which the full amount of the Rent Abatement has been fully applied to the Base Rent under this Lease subject to the terms and conditions set forth in Section 4.2.
		
	Rentable Area of Premises:	  	43,586 rentable square feet
		
	Rentable Area of Project:	  	123,210 square feet
		
	Tenant’s Share of Operating Expenses:	  	35.38%
		
	Lease Commencement Date:	  	The earlier of: (i) the Substantial Completion of Tenant’s Work (as set forth in Section 5.4) and Tenant’s occupancy of the Premises for purposes of conducting Tenant’s business operations; or (ii) January 1,
2014.


  
 2 









			
	Base Term:	  	Beginning on the Lease Commencement Date and ending on the last day of the one hundred eighth (108th) month thereafter.
		
	Extension Term:	  	One option for five (5) years as set forth in Section 28.
		
	Landlord’s Contribution:	  	Subject to Section 5.4 below, $150 per RSF of the Premises calculated to equal $6,537,900 based on Premises containing 43,586 RSF plus up to an additional $4,358.60 ($.10 per RSF) for out of pocket costs incurred in preparing the
initial test fit of the Premises.
		
	Permitted Use:	  	General office, research and development, laboratory and other related uses, including the use of a vivarium, consistent with the character of the Project and otherwise in compliance with the provisions of Section 6
hereof.
		
	Wiring and ACH Instructions for Rent Payment:	  	 Bank:                     Bank of
America
 Account Name:     150 Second Street LLC

Account Number:  4427702408
 ACH Routing /ABA Number:
111000012
 Wire Routing /ABA Number: 026009593
 Bank
Address:
 Mail Code:              GA1-006-09-10

                          
      Atlanta Plaza Building

                          
      600 Peachtree St NE

                          
      Atlanta, GA 30308-2265

		
	Parking:	  	As set forth in Section 7.
		
	Security Deposit:	  	$1,253,097.48 subject to the terms and conditions set forth in Section 27.
		
	General Liability Insurance:	  	$2,000,000.00 per occurrence/$3,000,000.00 aggregate (combined single limit) for property damage, bodily injury and death.
		
	Right of First Offer:	  	As set forth in Section 29.
		
	Landlord’s Notice Address:	  	 c/o Skanska USA Commercial Development Inc.

253 Summer Street
 Boston, MA 02210

Attn: Charles Leatherbee



  
 3 









			
	Tenant’s Notice Address:	  	 Prior to the Lease Commencement Date:
  

840 Memorial Drive
 Cambridge, MA 02139

Attention: Linda Bain
  

After the Lease Commencement Date:
  

150 Second Street
 Cambridge, MA 02139

Attention: Linda Bain

		
	Brokers:	  	Jones Lang LaSalle and Colliers International New England LLC

 The following Exhibits and Addenda are attached hereto and incorporated herein by this reference: 

EXHIBIT A - PLAN OF PREMISES, STORAGE SPACES AND SHARED SPACES 

EXHIBIT B - DESCRIPTION OF PROJECT 
 EXHIBIT C -
ACKNOWLEDGMENT OF LEASE COMMENCEMENT DATE 
 EXHIBIT D - RENT CERTIFICATE 

EXHIBIT E - BASE BUILDING SPECIFICATIONS 
 EXHIBIT F
- LANDLORD TENANT MATRIX 
 EXHIBIT G - TENANT’S CONCEPT PLAN 

EXHIBIT H - TENANT DESIGN AND CONSTRUCTION GUIDELINES 

EXHIBIT I - PARKING PLAN 
 EXHIBIT J - RULES AND
REGULATIONS 

  
 4 








 1.2 Definitions. 

“Abated Base Rent” shall have the meaning set forth in Section 4.2 hereof. 

“ADA” shall mean the Americans With Disabilities Act, 42 U.S.C. § 12101, et seq., together with the regulations
promulgated pursuant thereto. 
 “Additional Rent” shall have the meaning set forth in Section 4.3
hereof. 
 “AIA” shall mean the American Institute of Architects. 

“Alterations” shall have the meaning set forth in Section 9.1 hereof. 

“Annual Estimate” shall have the meaning set forth in Section 4.4 hereof. 

“Annual Statement” shall have the meaning set forth in Section 4.4 hereof. 

“Arbitrator” shall mean any person appointed by or on behalf of either party or appointed pursuant to the provisions hereof
and: (i) shall be (A) a member of the American Institute of Real Estate Appraisers with not less than 10 years of experience in the appraisal of improved office and high tech and life sciences laboratory real estate in the greater Boston,
Massachusetts metropolitan area, or (B) a licensed commercial real estate broker with not less than 15 years experience representing landlords and/or tenants in the leasing of high tech or life sciences laboratory space in the greater Boston,
Massachusetts metropolitan area, (ii) devoting substantially all of their time to professional appraisal or brokerage work, as applicable, at the time of appointment and (iii) be in all respects impartial and disinterested. 

“Assignment Date” shall have the meaning set forth in Section 17.2 hereof. 

“Assignment Notice” shall have the meaning set forth in Section 17.2 hereof. 

“Assignment Termination” shall have the meaning set forth in Section 17.2 hereof. 

“Base Rent” shall have the meaning set forth in Section 1.1 hereof. 

“Base Rent Abatement Period” shall have the meaning set forth in Section 4.2 hereof. 

“Base Term” shall have the meaning set forth in Section 1.1 hereof. 

“Business Day” shall mean any day other than (a) a Saturday or Sunday and (b) any Federal holiday or (c) a day
on which banks are not open for business generally in the Commonwealth of Massachusetts. 
 “Broker” shall have the meaning
set forth in Section 1.1 hereof. 
 “Building Systems” shall mean the structural, exterior, parking and
other Common Areas of the Project, including HVAC, plumbing, fire sprinklers, electrical, elevators and all other building systems serving the Premises and other portions of the Project. 

  
 5 








 “Claims” shall have the meaning set forth in Section 6.1
hereof. 
 “Common Areas” shall mean the portions of the Project which are for the non-exclusive use of tenants of the
Project. 
 “Default Rate” shall mean an annual rate equal to the lesser of 12% per annum or the highest rate
permitted by law. 
 “Default” shall have the meaning set forth in Section 16.1 hereof. 

“Environmental Claims” shall have the meaning set forth in Section 21.1. 

“Environmental Requirements” shall have the meaning set forth in Section 21.8 hereof. 

“Excess Rent” shall have the meaning set forth in Section 17.4 hereof. 

“Expense Information” shall have the meaning set forth in Section 4.4 hereof. 

“Extension Proposal” shall have the meaning set forth in Section 28.2 hereof. 

“Extension Right” shall have the meaning set forth in Section 28.1 hereof. 

“Extension Term” shall have the meaning set forth in Section 28.1 hereof. 

“Force Majeure” shall have the meaning set forth in Section 30.20 hereof. 

“Governmental Authority” shall have the meaning set forth in Section 4.6 hereof. 

“Haz Mat Documents” shall have the meaning set forth in Section 21.2 hereof. 

“Hazardous Materials Clearances” shall have the meaning set forth in Section 14.1 hereof. 

“Hazardous Materials List” shall have the meaning set forth in Section 21.2 hereof. 

“Hazardous Materials” shall have the meaning set forth in Section 21.8 hereof. 

“Holder” shall have the meaning set forth in Section 19.1 hereof. 

“Independent Review” shall have the meaning set forth in Section 4.4 hereof. 

“Installations” shall have the meaning set forth in Section 9.1 hereof. 

“Landlord’s Work” shall have the meaning set forth in Section 5.1 hereof. 

“Legal Requirement(s)” shall mean all laws, orders, judgments, ordinances, regulations, codes, directives, permits, licenses,
covenants and restrictions now or hereafter applicable to the Project, and to the use and occupancy thereof, including, without limitation, the ADA. 

  
 6 








 “Letter of Credit” shall have the meaning set forth in
Section 27.1 hereof. 
 “Market Rate” shall have the meaning set forth in
Section 28.1 hereof. 
 “Maximum Restoration Period” shall have the meaning set forth in
Section 14.1 hereof. 
 “Memorial Drive Lease” shall have the meaning set forth in
Section 4.2 hereof. 
 “Memorial Drive Rent Savings Event” shall have the meaning set forth in
Section 4.2 hereof. 
 “Mortgage” shall have the meaning set forth in Section 19.1
hereof. 
 “OFAC” shall mean the Office of Foreign Assets Control of the U.S. Department of Treasury. 

“OFAC Rules” shall mean the rules of OFAC and any statute, executive order, or regulation relating thereto. 

“Operating Expenses” shall have the meaning set forth in Section 4.4 hereof. 

“Permitted Assignment” shall have the meaning set forth in Section 17.2 hereof. 

“Permitted Use” shall have the meaning set forth in Section 1.1 hereof. 

“Premises” shall have the meaning set forth in Section 1.1 hereof. 

“Proceeding for Relief” shall have the meaning set forth in Section 16.1(f) hereof. 

“Project” shall have the meaning set forth in Section 1.1 hereof. 

“Related Parties” shall have the meaning set forth in Section 13.1 hereof. 

“Removable Installations” shall have the meaning set forth in Section 9.1 hereof. 

“Rent” shall mean Base Rent, Tenant’s Share of Operating Expenses and all other amounts payable by Tenant to Landlord
hereunder. 
 “Rent Abatement” shall have the meaning set forth in Section 4.2 hereof. 

“Rent Abatement Conditions” shall have the meaning set forth in Section 4.2 hereof. 

“Rentable Area of the Premises” shall have the meaning set forth in Section 1.1 hereof. 

“Rentable Area of the Project” shall have the meaning set forth in Section 1.1 hereof. 

“Rent Adjustment Percentage” shall mean three percent (3%). 

“Rent Certificate” shall have the meaning set forth in Section 4.2 hereof. 

  
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 “Security Deposit” shall have the meaning set forth in
Section 27.1 hereof. 
 “Substantial Completion” or “Substantially Complete” shall have
the meaning set forth in Section 5.4. 
 “Surrender Plan” shall have the meaning set forth in
Section 20.1 hereof. 
 “Taking” and “Taken” shall have the meaning set forth in
Section 15.1 hereof. 
 “Taxes” shall have the meaning set forth in Section 4.5
hereof. 
 “Tenant HazMat Operations” shall have the meaning set forth in Section 20.1 hereof. 

“Tenant Parties” shall have the meaning set forth in Section 10.1 hereof. 

“Tenant’s Property” shall have the meaning set forth in Section 9.1 hereof. 

“Tenant’s Share of Operating Expenses” shall have the meaning set forth in Section 1.1 hereof. 

“Tenant’s Share” shall mean the percentage set forth in the Basic Lease Provisions as Tenant’s Share as reasonably
adjusted by Landlord for changes in the physical size of the Premises or the Project occurring thereafter. 
 “Tenant’s
Work” shall have the meaning set forth in Section 5.2. 
 “Utilities” shall have the meaning
set forth in Section 8.1 hereof. 
 “Restoration Period” shall have the meaning set forth in
Section 14.1 hereof. 
 ARTICLE 2 

PREMISES; APPURTENANT RIGHTS; RESERVATIONS 

2.1 Lease of Premises. Upon and subject to all of the terms and conditions hereof, Landlord hereby leases the Premises to Tenant
and Tenant hereby leases the Premises from Landlord. 
 Excepted and excluded from the Premises and the Common Areas (as defined below) are
the ceiling, floor, perimeter walls and exterior windows (except the inner surface of each thereof), and any space in the Premises used for shafts, stacks, pipes, conduits, fan rooms, ducts, electric or other utilities, sinks or other Building
facilities, but the entry doors to the Premises are a part thereof, together with related glass and finish work. Landlord shall have the right to place in the Premises interior sun control devices, utility lines, cables and wiring, equipment,
stacks, pipes, conduits, ducts and the like, provided that any such installations shall be located above the ceiling or within the walls (except for the interior sun control devices which shall be located in or near the windows) and shall not
otherwise materially interfere with Tenant’s use, or materially reduce the rentable square footage of the Premises. 

  
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 2.2 Appurtenant Rights. Subject to the matters set forth in the following
paragraph, Tenant shall have, as appurtenant to the Premises, the non-exclusive right to use, and permit its invitees to use in common with Landlord and others, the following areas of the Property (collectively, the “Common
Areas”) (i) public or common lobbies, hallways, stairways, elevators (including but not limited to freight elevators) and common walkways necessary for access to the Building and the Premises, and if the portion of the Premises on
any floor includes less than the entire floor, any common toilets, any corridors required for access to the Premises and any elevator lobby of such floor; and (ii) the access roads, driveways, parking areas (as the same may be designated or
modified by Landlord from time to time), loading areas, pedestrian sidewalks, landscaped areas, trash enclosures (including but not limited to dumpsters maintained on the premises by Landlord), if any, and other areas or facilities, if any, which
are located in or on the Property and designated by Landlord from time to time for the non-exclusive use of tenants and other occupants of the Building. 

Landlord has designated certain areas located on the penthouse, ground level and garage level of the Building for Storage Space and Shared
Space, as shown on the plan attached hereto as Exhibit A, for use by the tenants of the Building. Tenant shall be allocated Tenant’s Share of the Storage Space and Shared Space, the location and use of which shall be reasonably
determined by Landlord and Tenant subject to applicable Legal Requirements, circulation requirements and Landlord’s reasonable requirements and conditions (including, without limitation, consideration for the utility of the unused portions of
the Storage Space and Shared Space by other tenants of the Building). The Storage Space and Shared Space shall be leased to Tenant on all of the terms and conditions of this Lease which are applicable to the Premises except as follows: (i) the
rent for Tenant’s Share of the Storage Space shall be the then applicable market rate (currently $18.00 per RSF); (ii) Landlord shall not have any obligation to make any improvements or alterations to the Storage Space and Shared Space to
prepare such space for Tenant’s use; (iii) Tenant shall use Tenant’s Share of the Storage Space and Shared Space solely for the storage or use of Tenant’s property or equipment and for no other purpose and in accordance with all
applicable Legal Requirements; (iv) Tenant, at its sole expense, shall keep Tenant’s Share of the Storage Space and Shared Space clean and in good condition; and (vi) Landlord shall not be required to provide any services for the
Storage Space and Shared Space. Notwithstanding the foregoing, as of the Effective Date, Tenant shall be deemed to have elected to lease the entire amount of Storage Space allocated to Tenant at the rate of $18.00 per RSF (gross) for the Term. If
Tenant subsequently elects to surrender any or all of such Storage Space to Landlord, Landlord may offer the surrendered Storage Space to other tenants in the Building and Tenant’s right to lease such surrendered Storage Space thereafter will
be subject to availability at such future time and Tenant’s payment at the then applicable market rental rate. 
 Notwithstanding any
provision herein to the contrary, Tenant’s rights under this Lease shall always be subject to (a) reservations, restrictions, easements and encumbrances of record, as amended from time to time, (b) such reasonable rules and
regulations from time to time established by Landlord with respect to the Property pursuant to Section 30.18 (the “Rules and Regulations”), and (c) Landlord’s reservations set forth in
Section 2.3 below or elsewhere in this Lease. 

  
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 2.3 Landlord Reservations. Notwithstanding any provision herein to the contrary,
Landlord reserves the right to: (i) grant, modify and terminate easements and other encumbrances so long as the same do not materially and adversely interfere with the Permitted Use by Tenant, (ii) designate and change from time to time
areas and facilities so to be used; provided however, that Landlord shall be responsible for any costs incurred in moving any of Tenant’s personnel, furniture, fixtures or equipment, (iii) make additions to the Building,
(iv) construct other buildings and improvements at the Property, (v) post “For Sale” and “For Lease” signs on the Property at any time during the Term, and (vi) change the name and street address of the Building
(provided, in such event, Landlord shall reimburse Tenant for its costs to implement such changes). Landlord reserves the right, at any time and from time to time, to make such changes, alterations, additions, improvements, repairs or replacements
in or to the Project (including the Premises but, with respect to the Premises, only for purposes of repairs, maintenance, replacements and other rights expressly reserved to Landlord herein) and the fixtures and equipment therein, as well as in or
to the street entrances and/or the Common Areas, as it may reasonably deem necessary or desirable, provided, however, that there be no material obstruction or modification of access to, or material interference with the use or enjoyment of, the
Premises or parking spaces by Tenant. Subject to the foregoing, provided reasonable prior written notice is given to Tenant and Tenant’s access to the Premises is not prohibited, Landlord shall have the right to temporarily close all, or any
portion, of the Common Areas for the purpose of making repairs or changes thereto. 
 ARTICLE 3 

DELIVERY OF PREMISES; ACCEPTANCE 

3.1 Delivery of Premises; Acceptance of Premises. Landlord shall deliver the Premises to Tenant upon the Effective Date provided
that Tenant has delivered the Security Deposit to Landlord and complied with the requirements of Article 13. Except as set forth in this Section 3.1 and Section 5.1(a), if applicable: (i) Tenant shall accept the Premises in their
condition as of the time of delivery, subject to all applicable Legal Requirements (as defined in Article 6 hereof); (ii) Landlord shall have no obligation for any defects in the Premises; and (iii) Tenant’s taking possession
of the Premises shall be conclusive evidence that Tenant accepts the Premises with Landlord’s Work completed pursuant to Section 5.1(a). 

Tenant agrees and acknowledges that, except as otherwise set forth in this Lease, neither Landlord nor any agent of Landlord has made any
representation or warranty with respect to the condition of all or any portion of the Premises or the Project, and/or the suitability of the Premises or the Project for the conduct of Tenant’s business, and Tenant waives any implied warranty
that the Premises or the Project are suitable for the Permitted Use. Notwithstanding the foregoing, Landlord represents to its knowledge that general office, research and development and laboratory uses are permitted uses pertaining to the Building
under the Zoning Ordinance of the City of Cambridge. This Lease constitutes the complete agreement of Landlord and Tenant with respect to the subject matter hereof and supersedes any and all prior representations, inducements, promises, agreements,
understandings and negotiations which are not contained herein. Landlord in executing this Lease does so in reliance upon Tenant’s representations, warranties, acknowledgments and agreements contained herein. 

3.2 Acknowledgment of Lease Commencement Date. Upon request of Landlord, Tenant shall execute and deliver a written
acknowledgment of the Lease Commencement Date, Rent Commencement Date and the expiration date of the Term when such dates are established in accordance with the requirements of this Lease substantially in the form of the “Acknowledgement 

  
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of Lease Commencement Date” attached to this Lease as Exhibit C ; provided, however, Tenant’s failure to execute and deliver such acknowledgment shall not affect
Landlord’s rights hereunder. The “Term” of this Lease shall be the Base Term, as defined above on the first page of this Lease and, if applicable, the Extension Term which Tenant may elect pursuant to Article 28
hereof. 
 ARTICLE 4 

RENT 
 4.1
Base Rent. The first month’s Base Rent shall be due and payable on the Lease Commencement Date and the Security Deposit shall be due and payable on delivery of an executed copy of this Lease to Landlord. Tenant shall pay to Landlord
in advance, without demand, abatement, deduction or set-off, equal monthly installments of Base Rent on or before the first day of each calendar month during the Term hereof, in lawful money of the United States of America, at the office of Landlord
for payment of Rent set forth above, or to such other person or at such other place as Landlord may from time to time designate in writing. Payments of Base Rent for any fractional calendar month shall be prorated. The obligation of Tenant to pay
Base Rent and other sums to Landlord and the obligations of Landlord under this Lease are independent obligations. Tenant shall have no right at any time to abate, reduce, or set-off any Rent (as defined in Section 1.2) due hereunder except for
any abatement, reduction or set-off as may be expressly provided in this Lease. 
 4.2 Base Rent Abatement Period.
Notwithstanding anything in this Section of the Lease to the contrary, so long as Tenant is not in Default (as defined in Section 16.1) under this Lease, Tenant shall be entitled to an abatement of Base Rent in the amount of $208,849.58 per
month for six (6) consecutive full calendar months of the Base Term beginning on the Lease Commencement Date (“Rent Abatement”). The period during which the foregoing Base Rent abatement rights are in effect shall be
referred to as the “Base Rent Abatement Period” and the amount of Base Rent permitted to be abated shall be referred to as the “Abated Base Rent”. During the Base Rent Abatement Period, only Base Rent
shall be abated as provided in this Section, and all Additional Rent and other costs and charges specified in this Lease shall remain as due and payable pursuant to the provisions of this Lease. 

As an inducement to Tenant’s entering into this Lease, Landlord offers the Rent Abatement in order to offset Tenant’s rent
obligation under its current lease pertaining to the premises located at 840 Memorial Drive, Cambridge, Massachusetts (“Memorial Drive Lease”), a true, accurate and complete copy of which Tenant shall provide to Landlord
prior to the Effective Date of this Lease. Accordingly, Landlord and Tenant agree that if Tenant’s out of pocket rent obligation under the Memorial Drive Lease is reduced or eliminated by virtue of entering into an assignment or sublease,
termination agreement or suffering a recapture of such premises or other such means (each, a “Memorial Drive Rent Savings Event”), Landlord and Tenant shall split Tenant’s rent savings under the Memorial Drive Lease on a
60% to Landlord and 40% to Tenant basis after the deduction of reasonable documented transaction costs, including, but not limited to legal and brokerage fees and tenant improvement allowances. 

  
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 In order to receive the Rent Abatement and to account for the occurrence of a Memorial Drive Rent
Savings Event, Tenant shall comply with the following requirements (collectively, the “Rent Abatement Conditions”): 
  

	 	i.	Upon the Lease Commencement Date and the first day of each successive month thereafter until the expiration or earlier termination of the term of the Memorial Drive Lease, Tenant shall deliver to Landlord a Rent
Certificate substantially in the form attached hereto as Exhibit D (“Rent Certificate”) whereby Tenant certifies to Landlord, among other things, the amount of Tenant’s actual out of pocket rent payment
under the Memorial Drive Lease for the applicable monthly period. 

  

	 	ii.	Upon Landlord’s receipt of the Rent Certificate, Tenant’s obligation to pay the Base Rent for the applicable month shall abate. 


If the Rent Certificate indicates that a Memorial Drive Rent Savings Event has occurred, the amount of the Rent Abatement that may be applied
to Base Rent hereunder shall be reduced by the portion of the rent savings allocated to Landlord as Tenant realizes the actual rent savings under the Memorial Drive Lease. If a Memorial Drive Rent Savings Event has occurred and the amount of the
rent savings under the Memorial Drive Lease is greater than the remaining amount of the Rent Abatement at such time, then Tenant shall pay Landlord, as additional rent, the rent savings allocated to Landlord amortized over the remainder of the
stated term of the Memorial Drive Lease. The following examples illustrate three (but not all) possible scenarios that may arise in any given month during the Base Rent Abatement Period under this Section: 

(a) No Memorial Drive Rent Savings Event Occurs Before the Expiration of the Base Rent Abatement Period: 

 

	 	1.	Tenant submits a Rent Certificate to Landlord evidencing that no Memorial Drive Rent Savings Event has occurred. 

  

	 	2.	Tenant pays the monthly base rent of approximately $35.290.60 to landlord under the Memorial Drive Lease. 

  

	 	3.	The Monthly Base Rent of $208,849.58 due to Landlord pursuant to Section 1.1 hereof is abated. 


(b) Memorial Drive Rent Savings Event Occurs Before the Expiration of the Base Rent Abatement Period: 

 

	 	1.	Tenant submits a Rent Certificate to Landlord evidencing that Tenant and the landlord under the Memorial Drive Lease have entered into a lease termination agreement (i.e. a Memorial Drive Rent Savings Event) yielding a
rent savings of $500,000 (after deduction of Tenant’s reasonable documented transaction costs). 

  

	 	2.	Landlord’s share of the rent savings is $300,000 and Tenant’s share of the rent savings is $200,000. 

  

	 	3.	Tenant pays the net monthly rent (or no monthly rent, as the case may be) due to landlord under the Memorial Drive Lease after accounting for the rent savings under the Memorial Drive Lease. 


  
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	 	4.	The amount of Rent Abatement that may be applied to Base Rent is reduced by $300,000 (the amount of Landlord’s share of the rent savings). Therefore, Tenant pays Base Rent of $208,849.58 to Landlord plus additional
rent of $91,150.42 ($208,849.58 + $91,150.42 = $300,000 rent savings due Landlord). 

 (c) Memorial Drive Rent
Savings Event Occurs After the Expiration of the Base Rent Abatement Period: 
  

	 	1.	Tenant submits a Rent Certificate to Landlord evidencing that Tenant and the landlord under the Memorial Drive Lease have entered into a lease termination agreement (i.e. a Memorial Drive Rent Savings Event) yielding a
rent savings of $500,000 (after deduction of Tenant’s reasonable documented transaction costs). 

  

	 	2.	Landlord’s share of the rent savings is $300,000 and Tenant’s share of the rent savings is $200,000. 

  

	 	3.	Tenant pays the net monthly rent (or no monthly rent, as the case may be) due to landlord under the Memorial Drive Lease after accounting for the rent savings under the Memorial Drive Lease. 


 

	 	4.	Assuming five months remaining in the term under the Memorial Drive Lease, the monthly amount of the Landlord’s share of the rent savings amortized on a straight line basis over the unexpired portion of the term
under the Memorial Drive Lease is $60,000 ($300,000 ÷ 5 months). 

  

	 	5.	Tenant pays the applicable monthly Rent to Landlord due under this Lease plus additional rent of $60,000 for five consecutive months. 


In the event of any inconsistency or conflict between the numeric examples provided above and the written provisions set forth in this
Section, the written text shall govern. 
 If Tenant fails to comply with the requirements set forth in this Section 4.2, Tenant shall
be obligated to pay the applicable Base Rent. If a Rent Certificate is inaccurate or if Tenant and Landlord have failed to properly account for a previously-occurring Memorial Drive Rent Savings Event, then Tenant shall be obligated to prepare and
deliver a Rent Certificate addressing such inaccuracy or failure and shall pay to Landlord the Landlord’s share of any previously Abated Base Rent. 

4.3 Additional Rent. In addition to Base Rent, commencing on the Lease Commencement Date, Tenant agrees to pay to Landlord as
additional rent (“Additional Rent”): (i) Tenant’s Share of “Operating Expenses” (as defined in Section 4.5), and (ii) any and all other amounts Tenant assumes or agrees to pay to Landlord under
the provisions of this Lease, including, without limitation, any and all other sums that may become due by reason of any default of Tenant or failure to comply with the agreements, terms, covenants and conditions of this Lease to be performed by
Tenant, after any applicable notice and cure period. 

  
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 4.4 Intentionally Omitted. 

4.5 Operating Expense Payments. Landlord shall deliver to Tenant a written estimate of Operating Expenses for each calendar year
during the Term (the “Annual Estimate”) which may be revised by Landlord from time to time during such calendar year. During each month of the Term commencing on the Lease Commencement Date, on the same date that Base Rent is
due, Tenant shall pay Landlord an amount equal to 1/12th of Tenant’s Share of the Annual Estimate. Payments for any fractional calendar month shall be prorated. If Landlord fails to give Tenant the Annual Estimate prior to the beginning of any
calendar year, Tenant shall continue to pay Operating Expenses in accordance with the previous Annual Estimate, until Tenant receives a new statement from Landlord. 

The term “Operating Expenses” means all costs and expenses of any kind or description whatsoever incurred or accrued
each calendar year by Landlord in operating, maintaining, repairing, and managing the Building and the Project including, without duplication, Taxes (as defined in Section 4.5 ), capital repairs and improvements
(1) reasonably projected to reduce the amount of Operating Expenses payable by Tenant, or (2) required to comply with any Legal Requirements that first become effective and applicable to the Project after the date of this Lease, amortized
over-the useful life of such capital items as determined in accordance with generally accepted accounting principles, costs for transportation services for the benefit of the tenants of the Building and a property management fee at fair market rates
not to exceed 3.0% of Base Rent, excluding only: 
 (a) the original construction costs of the Project and renovation prior to the
date of the Lease and costs of correcting defects in such original construction or renovation (including Landlord’s Work); 

(b) capital expenses for the Project except as expressly permitted above; 

(c) interest, principal and other payments pursuant to a Mortgage (as defined in Section 19.1 ) debts of Landlord, ground
rent, financing costs and amortization of funds borrowed by Landlord, whether secured or unsecured; 
 (d) depreciation of the
Project (except for capital improvements, the cost of which are includable in Operating Expenses); 
 (e) advertising, promotional,
legal and space planning expenses and leasing commissions and other costs and expenses incurred in procuring and leasing space to tenants for the Project, including any leasing office maintained in the Project, free rent and construction allowances
for tenants; 
 (f) legal and other expenses incurred in the negotiation or enforcement of leases; 

(g) completing, fixturing, improving, renovating, painting, redecorating or other work, which Landlord pays for or performs for other
tenants within their premises, and costs of correcting defects in such work; 

  
 14 








 (h) costs to be reimbursed by other tenants of the Project or Taxes to be paid directly by
Tenant or other tenants of the Project, whether or not actually paid; 
 (i) The cost of any work or services performed for any other
property other than the Project, including, without limitation, salaries, wages, benefits and other compensation paid to employees of Landlord who are not assigned in whole or in part to the operation, management, maintenance or repair of the
Project; 
 (j) salaries, wages, benefits and other compensation paid to officers and executives of Landlord and administrative
employees above the grade of property manager or building supervisor and Landlord’s general overhead; 
 (k) general
organizational, administrative and overhead costs relating to maintaining Landlord‘s existence, either as a corporation, partnership, or other entity, including general corporate, legal and accounting expenses; 

(l) costs (including attorneys’ fees and costs of settlement, judgments and payments in lieu thereof) incurred in connection with
disputes with tenants, other occupants, or prospective tenants, and costs and expenses, including legal fees, incurred in connection with negotiations or disputes with employees, consultants, management agents, leasing agents, purchasers or
mortgagees of the Building; 
 (m) costs incurred by Landlord due to the violation by Landlord, its employees, agents or contractors
or any tenant of the terms and conditions of any lease of space in the Project or any Legal Requirement (as defined in Section 1.2 ); 

(n) penalties, fines or interest incurred as a result of Landlord‘s inability or failure to make payment of Taxes and/or to file
any tax or informational returns when due, or from Landlord’s failure to make any payment of Taxes required to be made by Landlord hereunder before delinquency; 

(o) overhead and profit increment paid to Landlord or to subsidiaries or affiliates of Landlord for goods and/or services in or to the
Project to the extent the same exceeds the costs of such goods and/or services rendered by unaffiliated third parties on a competitive basis; 

(p) costs of Landlord’s charitable or political contributions, or of fine art maintained at the Project; 

(q) costs in connection with services (including electricity), items or other benefits of a type which are not standard for the Project
and which are not available to Tenant without specific charges therefor, but which are provided to another tenant or occupant of the Project, whether or not such other tenant or occupant is specifically charged therefor by Landlord; 

(r) costs incurred in the sale or refinancing of the Project; 

(s) costs for remediation, abatement, removal or encapsulation of Hazardous Materials at the Project other than routine cleaning and
maintenance which may involve the same; 

  
 15 








 (t) net income taxes of Landlord or the owner of any interest in the Project, franchise,
capital stock, gift, estate or inheritance taxes or any federal, state or local documentary taxes imposed against the Project or any portion thereof or interest therein; and 

(u) any expenses otherwise includable within Operating Expenses to the extent actually reimbursed by persons other than tenants of the
Project under leases for space in the Project. 
 Within 90 days after the end of each calendar year (or such longer period as may be
reasonably required), Landlord shall furnish to Tenant a statement (an “Annual Statement”) showing in reasonable detail: (a) the total and Tenant’s Share of actual Operating Expenses for the previous calendar year,
and (b) the total of Tenant’s payments in respect of Operating Expenses for such year. If Tenant’s Share of actual Operating Expenses for such year exceeds Tenant’s payments of Operating Expenses for such year, the excess shall
be due and payable by Tenant as Rent within 30 days after delivery of such Annual Statement to Tenant. If Tenant’s payments of Operating Expenses for such year exceed Tenant’s Share of actual Operating Expenses for such year, the excess
shall be credited against the next due amounts of Rent, provided that any overpayment shall be paid to Tenant within thirty (30) days if the Term has ended, provided that if Tenant is delinquent in its obligation to pay Base Rent or Additional
Rent, Landlord shall pay the excess to Tenant after deducting all other amounts due Landlord. 
 The Annual Statement shall be final and
binding upon Tenant unless Tenant, within 90 days after Tenant’s receipt thereof, shall contest any item therein by giving written notice to Landlord, specifying each item contested and the reason therefor. If, during such 90 day period, Tenant
reasonably and in good faith questions or contests the accuracy of Landlord’s statement of Tenant’s Share of Operating Expenses, provided that Tenant pays any amount due on the Annual Statement if applicable, Landlord will provide Tenant
with access to Landlord’s books and records relating to the operation of the Project and such information as Landlord reasonably determines to be responsive to Tenant’s questions (the “Expense Information”). If
Landlord and Tenant cannot agree upon the amount of Tenant’s Share of Operating Expenses within thirty (30) days after Tenant’s review of such Expense Information, then Tenant shall have the right to have an independent public
accounting firm selected by Tenant, working pursuant to a fee arrangement other than a contingent fee (at Tenant’s sole cost and expense) and approved by Landlord (which approval shall not be unreasonably withheld, conditioned or delayed),
audit and/or review the Expense Information for the year in question (the “Independent Review”). The results of any such Independent Review shall be binding on Landlord and Tenant. If the Independent Review shows that the
payments actually made by Tenant with respect to Operating Expenses for the calendar year in question exceeded Tenant’s Share of Operating Expenses for such calendar year, Landlord shall at Landlord’s option either (i) credit the
excess amount to the next succeeding installments of estimated Operating Expenses or (ii) pay the excess to Tenant within 30 days after delivery of such statement, except that after the expiration or earlier termination of this Lease or if
Tenant is delinquent in its obligation to pay Rent, Landlord shall pay the excess to Tenant after deducting all other amounts due Landlord. If the Independent Review shows that Tenant’s payments with respect to Operating Expenses for such
calendar year were less than Tenant’s Share of Operating Expenses for the calendar year, Tenant shall pay the deficiency to Landlord within 30 days after delivery of such statement. If the Independent Review shows that Tenant has overpaid with
respect to Operating Expenses stated in the Annual Statement or any adjustments made 

  
 16 








 
thereafter by more than 5% then Landlord shall reimburse Tenant for all costs incurred by Tenant for the Independent Review. Operating Expenses for the calendar years in which Tenant’s
obligation to share therein begins and ends shall be prorated. Notwithstanding anything set forth herein to the contrary, if the Project is not at least 95% occupied on average during any year of the Term, Tenant’s Share of Operating Expenses
that vary according to occupancy of the Project for such year shall be computed as though the Project had been 95% occupied on average during such year. 

“Tenant’s Share” shall be the percentage set forth on the first page of this Lease as Tenant’s Share as
reasonably adjusted by Landlord for changes in the physical size of the Premises or the Project occurring thereafter. Landlord may equitably adjust Tenant’s Share for any item of expense or cost reimbursable by Tenant that relates to a repair,
replacement, or service that benefits only the Premises or only a portion of the Project that includes the Premises, which adjustment may be reviewed by Tenant as part of the Independent Review. Base Rent, Tenant’s Share of Operating Expenses
and all other amounts payable by Tenant to Landlord hereunder are collectively referred to herein as “Rent.” 

4.6 Taxes. Tenant shall pay, as part of Operating Expenses, all taxes, levies, fees, assessments and governmental charges of any
kind, existing as of the Lease Commencement Date or thereafter enacted (collectively referred to as “Taxes”), imposed by any federal, state, regional, municipal, local or other governmental authority or agency, including,
without limitation, quasi-public agencies (collectively, “Governmental Authority”) during the Term, including, without limitation, all Taxes: (i) imposed on or measured by or based, in whole or in part, on rent payable
to (or gross receipts received by) Landlord under this Lease and/or from the rental by Landlord of the Project or any portion thereof, or (ii) based on the square footage, assessed value or other measure or evaluation of any kind of the
Premises or the Project, or (iii) assessed or imposed by or on the operation or maintenance of any portion of the Premises or the Project, including parking, or (iv) assessed or imposed by, or at the direction of, or resulting from Legal
Requirements, or interpretations thereof, promulgated by any Governmental Authority, or (v) imposed as a license or other fee, charge, tax, or assessment on Landlord’s business or occupation of leasing space in the Project. The prorated
portion of any Taxes that are due and payable pertaining to periods prior to the Lease Commencement Date or after the expiration of the Term shall not be Tenant’s obligation to pay hereunder. Landlord may contest by appropriate legal
proceedings the amount, validity, or application of any Taxes or liens securing Taxes. If a change in Taxes is obtained for any year of the Term during which Tenant paid Tenant’s Share of Taxes, then Taxes for that year will be retroactively
adjusted and Landlord shall provide Tenant with a credit, if any, based on the adjustment. Taxes shall not include any net income taxes imposed on Landlord except to the extent such net income taxes are in substitution for any Taxes payable
hereunder. If any such Tax is levied or assessed directly against Tenant, then Tenant shall be responsible for and shall pay the same at such times and in such manner as the taxing authority shall require. Tenant shall pay, prior to delinquency, any
and all Taxes levied or assessed against any personal property or trade fixtures placed by Tenant in the Premises, whether levied or assessed against Landlord or Tenant. If any Taxes on Tenant’s personal property or trade fixtures are levied
against Landlord or Landlord’s property, or if the assessed valuation of the Project is expressly increased by the taxing authority by a value attributable to improvements in or alterations to the Premises, whether owned by Landlord or Tenant
and whether or not affixed to the real property so as to become a part thereof, higher than the base valuation on which Landlord 

  
 17 








 
from time-to-time allocates Taxes to all tenants in the Project, Landlord shall have the right, but not the obligation, to pay such Taxes. Landlord’s determination of any excess assessed
valuation shall be binding and conclusive, absent manifest error. The amount of any such payment by Landlord shall constitute Additional Rent due from Tenant to Landlord within thirty (30) days. 

ARTICLE 5 
 CONDITION
OF PREMISES; CONSTRUCTION 
 5.1 Base Building Work. 

(a) Landlord shall deliver the Premises to Tenant upon the Effective Date with the work (“Landlord’s Work”)
more particularly described in the base building specifications attached hereto as Exhibit E (“Base Building Specifications”) completed. Landlord’s Work shall comply with the Legal Requirements and shall be
consistent with Class A standards for laboratory and office space, and substantially in conformance with, and not materially inconsistent with, the Base Building Specifications. Landlord shall deliver the Premises to Tenant with all base
building systems, including, but not limited to, HVAC, electrical, life safety and plumbing systems in good working order, in compliance with applicable Legal Requirements and suitable for laboratory purposes. The allocation of the responsibilities
between the Landlord’s Work and Tenant’s Work is set forth on the Landlord/Tenant Matrix attached hereto as Exhibit F (“Landlord/Tenant Matrix”). 

(b) Tenant agrees, except as otherwise provided herein to the contrary, (i) to accept possession of the Premises in the condition
described in the Base Building Specifications and otherwise in “as is” condition, (ii) that neither Landlord nor Landlord’s agents have made any representations or warranties with respect to the Premises or the Building except as
provided herein, and (iii) Landlord has no obligation to perform any work, supply any materials, incur any expense or make any alterations, additions or improvements to the Premises to prepare the Premises for Tenant’s use and occupancy
except as provided herein. 
 5.2 Tenant’s Work. 

(a) Tenant shall prepare, at its sole cost and expense (against which the Landlord’s Contribution may be applied), a set of
design/development plans in substantial conformity with the concept plan approved by Landlord (subject to Landlord’s review of further details regarding access and maintenance of the tel/data room and access, maintenance and ventilation issues
in connection with components located on the third floor along the window line) and attached hereto as Exhibit G, Tenant Design and Construction Guidelines attached hereto as Exhibit H (“Tenant Design and
Construction Guidelines”) and the allocation of responsibilities set forth in the Landlord/Tenant Matrix sufficient for Landlord to approve Tenant’s proposed design of the Premises (“Design/Development
Plans”), and a full set of final permit-ready construction drawings (“Final Construction Drawings”) for the interior finish and layout of the initial improvements ( “Tenant’s
Work” ) which Tenant desires to have performed in the Premises. The Design/ Development Plans and the Final Construction Drawings are collectively referred to herein as the “Plans.” Provided that no
Default has occurred and remains outstanding, Landlord shall reimburse Tenant up to $4,358.60 ($.10 per RSF) for out of pocket costs incurred in preparing the initial test fit of the Premises. 

  
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 (b) The Plans shall be submitted to Landlord, together with a construction budget setting
forth the anticipated costs for the Tenant’s Work, and Landlord shall approve or disapprove of the Plans, which approval shall not be unreasonably withheld, conditioned or delayed, and Landlord shall respond in any event within fifteen
(15) days of receiving them. No work shall be conducted by or on behalf of Tenant until the Final Construction Drawings have been approved for such work in writing by Landlord. At Tenant’s sole cost and expense (against which the
Landlord’s Contribution may be applied), Tenant shall cause the Plans to be revised in a manner sufficient to remedy the Landlord’s objections and/or respond to the Landlord’s concerns and for such revised Plans to be redelivered to
Landlord, and Landlord shall approve or disapprove such portions of the Plans to which Landlord previously commented within seven (7) Business Days following the date of resubmission. Landlord’s failure to timely respond to Tenant’s
submitted Plans or revised Plans shall be deemed to be approval thereof provided that upon submitting such plans, Tenant provides written notice to Landlord stating “IF LANDLORD FAILS TO RESPOND TO THE ENCLOSED PLANS WITHIN 15 DAYS (OR
7 BUSINESS DAYS AS APPLICABLE), LANDLORD’S APPROVAL SHALL BE DEEMED GIVEN PURSUANT TO SECTION 5.2(b) OF THE LEASE” in upper case boldface type in the top margin of such notice. Landlord’s approval is solely given for the benefit
of Landlord and Tenant under this Section and neither Tenant nor any third party shall have the right to rely upon Landlord’s approval of the Plans for any other purpose whatsoever. 

(c) Landlord shall not charge Tenant any coordination, overhead or contractor supervision fees in connection with Tenant’s Work;
provided, however that Landlord shall be reimbursed from the Landlord’s Contribution for any third-party, out of pocket expenses incurred by Landlord in connection with the review and approval of Tenant’s Work. 

(d) The Plans shall be stamped by a Massachusetts registered architect and engineer, such architect and engineer and Tenant’s
general contractor and subcontractors, being subject to Landlord’s prior approval, which shall not be unreasonably withheld, conditioned or delayed, and shall comply with the Legal Requirements and the requirements of the Tenant Design and
Construction Guidelines. The final approved Plans shall be in a form satisfactory to appropriate governmental authorities responsible for issuing permits, approvals and licenses required for Tenant’s Work. 

(e) Tenant’s Work shall be completed in accordance with the Plans and no material changes to Tenant’s Work shall occur
without Landlord’s approval as set forth herein. All of the Tenant’s Work shall be performed in accordance with the requirements set forth in the Tenant Design and Construction Guidelines and completed in a first class workmanlike manner.
Tenant shall be solely responsible for the effect of the Tenant’s Work on the Building’s structure and systems, whether or not Landlord has consented to the Alterations, and shall reimburse Landlord on demand for any costs incurred by
Landlord by reason of any faulty work done by Tenant or its contractors. All of Tenant’s Work shall be performed in such manner as to maintain harmonious labor relations and to minimize any material interference with Building operations or
other construction work being performed within the Building. 
 (f) Tenant shall use diligent efforts to keep the Project and
Tenant’s leasehold interest therein free of any liens or claims of liens arising from acts or omissions of Tenant, or its subtenants, contractors or others claiming by, through or under Tenant, and shall discharge or bond

  
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 any such liens within ten (10) Business Days following notice to Tenant of their filing. Before commencement
of any work, upon Landlord’s request, Tenant’s contractor shall provide a payment, performance and lien indemnity bond required by Landlord. Tenant shall provide evidence of such insurance as Landlord may reasonably require, naming
Landlord as an additional insured. Tenant shall indemnify Landlord and hold it harmless from and against any cost, claim, or liability arising from any work done by or at the direction of Tenant. 

(g) All alterations affixed to the Premises shall become part thereof and remain therein at the end of the Term unless otherwise agreed
to by Landlord and Tenant. However, if Landlord gives Tenant a notice, at the time Landlord approves the Plans, to remove any alterations, Tenant shall do so and shall pay the cost of removal and any repair required by such removal. 

(h) All of Tenant’s personal property, trade fixtures, equipment, furniture, movable partitions, and any alterations not affixed
to the Premises shall remain Tenant’s property, removable at any time. If Tenant fails to remove any such materials at the end of the Term, Landlord may do so and store them at Tenant’s expense, without liability to Tenant, and may sell
them at public or private sale and apply the proceeds to any amounts due hereunder, including costs of removal, storage and sale. 
 5.3
Intentionally Deleted. 
 5.4 Landlord’s Contribution. (a) As an inducement to Tenant’s
entering into this Lease, Landlord shall, subject to the terms set forth in this Section, provide to Tenant a special tenant improvement allowance for the actual costs incurred with respect to the design and hard construction costs pertaining to
Tenant’s Work up to a maximum aggregate amount of Six Million Five Hundred Thirty Seven Thousand Nine Hundred and 00/100 Dollars ($6,537,900.00) [$150.00 per RSF] less any past due expenses owed to Landlord by Tenant under this Lease
(“Initial Allowance”). 
 (b) Landlord shall pay to Tenant an amount not to exceed Landlord’s
Contribution to the extent permitted pursuant to this Section, provided that as of the date on which Landlord is required to make payment thereof pursuant to this Section: (i) this Lease is in full force and effect, and (ii) no Event of
Default then exists. Tenant shall pay all costs of the Tenant’s Work in excess of Landlord’s Contribution. Before Tenant submits a requisition request for any hard construction costs, Landlord agrees to fund up to fifty percent
(50%) of Tenant’s early design fees from Landlord’s Contribution, with the balance of such design fees to be funded on a dollar for dollar basis as the hard construction costs are funded. Thereafter, each funded requisition for
Landlord’s Contribution shall be applied first on account of any hard construction costs and labor directly related to the Tenant’s Work and materials delivered to the Building in connection with the Tenant’s Work, and then, second on
account of any design fees. If, following the expiration of the six (6) month period following the completion of the Tenant’s Work and satisfaction of the conditions set forth in this Section, any amount of Landlord’s Contribution has
not been requisitioned by Tenant, such remainder shall be retained by Landlord and Tenant shall have no further right to claim thereto. 

  
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 (c) Landlord shall make progress payments on account of Landlord’s Contribution to
Tenant on a monthly basis, for the work performed during the previous month, less such retainage (“Retainage”) as is provided for in Tenant’s construction contract(s) and contracts for the purchase and delivery of
furniture, fixtures and equipment, provided that such contracts shall require Retainage of not less than five percent (5%) of the total contract price (in the aggregate) (which 5% Retainage shall not be in addition to the amounts retained under
such contracts). 
 (d) Landlord shall pay Landlord’s Proportion (hereinafter defined) of the cost shown on each requisition
submitted by Tenant to Landlord until the entirety of Landlord’s Contribution has been exhausted. “Landlord’s Proportion” shall be a fraction, the numerator of which is Landlord’s Contribution and the
denominator of which is the total contract price for Tenant’s Work (as evidenced by reasonably detailed documentation delivered to Landlord with the requisition first submitted by Tenant). 

Landlord’s progress payments shall be made payable directly to Tenant or, upon Tenant’s written request, to Tenant’s general
contractor, within thirty (30) days following the delivery to Landlord of requisitions therefor. Landlord shall have the right, upon reasonable advance notice to Tenant, to inspect Tenant’s books and records relating to each requisition in
order to verify the amount thereof. Tenant shall submit requisition(s) no more often than monthly. Each such requisition shall be executed by a duly authorized officer of Tenant, and shall be accompanied by (i) with the exception of the first
requisition, copies of partial waivers of lien from all contractors, subcontractors, and material suppliers covering all work and materials which were the subject of previous progress payments by Landlord and Tenant, (ii) a certification from
Tenant’s architect on a completed AIA Form G702, and (iii) a requisition certificate on a completed AIA Form G703. Landlord shall hold such Retainage and disburse the Retainage, or portions thereof as requisitioned by Tenant from time to
time on account of subcontractors who have completed their respective portions of the job, upon submission by Tenant to Landlord of Tenant’s requisition therefor accompanied by all documentation required under the foregoing provisions of this
Section, together with (A) proof of the satisfactory completion of all required inspections and issuance of any required approvals, permits and sign offs for the work of such subcontractor, or with respect to the work of the Tenant’s
general contractor, the Tenant’s Work, by Governmental Authorities having jurisdiction thereover (including issuance of the Certificate of Occupancy) (“Substantial Completion of Tenant’s Work”), and
(B) issuance of final lien waivers by all contractors, subcontractors and material suppliers covering all of the Tenant’s Work or the portion thereof as applicable (which final lien waivers may be conditioned upon, or delivered concurrent
with, payment of such Retainage). If Tenant fails to pay to Tenant’s contractors the amounts paid by Landlord to Tenant in connection with any previous requisition(s), Landlord shall thereafter have the right to have Landlord’s
Contribution paid directly to Tenant’s contractors. In addition, concurrent with the final requisition for the Retainage, Tenant shall submit “as-built” plans and specifications for the Tenant’s Work. The right to receive
Landlord’s Contribution is for the exclusive benefit of Tenant, and in no event shall such right be assigned to or be enforceable by or for the benefit of any third party, including any contractor, subcontractor, materialman, laborer,
architect, engineer, attorney or other person or entity (excepting only to a permitted assignee of this Lease pursuant to Article 17). 

  
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 ARTICLE 6 

USE 
 6.1
Use. The Premises shall be used solely for the Permitted Use set forth in the basic lease provisions in Section 1.1 of this Lease, and in compliance with all Legal Requirements now or hereafter applicable to the
Premises, and to the use and occupancy thereof, including, without limitation, the Americans With Disabilities Act, 42 U.S.C. § 12101, et seq. (together with the regulations promulgated pursuant thereto, “ADA”). Tenant
shall, upon 5 days’ written notice from Landlord, discontinue any use of the Premises which is declared by any Governmental Authority (as defined in Section 4.6) having jurisdiction to be a violation of a Legal Requirement.
Tenant will not use or permit the Premises to be used for any purpose or in any manner that would void Tenant’s or Landlord’s insurance, increase the insurance cost, or cause the disallowance of any sprinkler or other credits. Tenant shall
reimburse Landlord promptly upon demand for any additional premium charged for any such insurance policy by reason of Tenant’s failure to comply with the provisions of this Section or otherwise caused by Tenant’s use and/or occupancy of
the Premises. Tenant will use the Premises in a careful, safe and proper manner and will not commit or permit waste, overload the floor or structure of the Premises, subject the Premises to use that would damage the Premises or obstruct or interfere
with the rights of Landlord or other tenants or occupants of the Project, including conducting or giving notice of any auction, liquidation, or going out of business sale on the Premises, or using or allowing the Premises to be used for any unlawful
purpose. Tenant shall cause any equipment or machinery to be installed in the Premises so as to reasonably prevent sounds or vibrations from the Premises from extending into Common Areas, or other space in the Project. Tenant shall not, without the
prior written consent of Landlord use the Premises in any manner which will require ventilation, air exchange, heating, gas, steam, electricity or water beyond the capacity of the Project as set forth in this Lease. 

Tenant, at its sole expense, shall make any alterations or modifications to the interior or the exterior of the Premises or the Project that
are required by Legal Requirements (including, without limitation, compliance of the Premises with the ADA) related to Tenant’s use or occupancy of the Premises. Notwithstanding any other provision herein to the contrary, Tenant shall be
responsible for any and all demands, claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses incurred in investigating or resisting the same (including, without limitation,
reasonable attorneys’ fees, charges and disbursements and costs of suit) (collectively, “Claims”) arising out of or in connection with Legal Requirements related to Tenant’s use or occupancy of the Premises, and
Tenant shall indemnify, defend, hold and save Landlord harmless from and against any and all Claims arising out of or in connection with any failure of the Premises to comply with any Legal Requirement (to the extent that such Claims do not arise
from the failure of Landlord’s Work to comply with any Legal Requirements). 
 ARTICLE 7 

PARKING 
 7.1
Parking. Subject to all matters of record, Force Majeure, a Taking and the exercise by Landlord of its rights hereunder, Tenant shall have the right, in common with other tenants of the Project to use Tenant’s pro rata share of the
non-reserved parking spaces at the Project at the then-current prevailing rate equal to (a) .65 parking spaces per 1,000 rentable square feet of the Premises (or 28 spaces based on 43,586 RSF) for the parking spaces located in the Building
garage 

  
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at the current monthly fee of $225 per space, and (b) .35 parking spaces per 1,000 rentable square feet of the Premises (or 15 spaces based on 43,586 RSF) for surface parking spaces located
on the adjacent lot at the current monthly fee of $175 per space, as such rates may vary from time to time to reflect current fair market parking rates in East Cambridge and Kendall Square, as shown on the parking plan attached hereto as
EXHIBIT I (“Parking Plan”). Subject to Landlord’s reasonable requirements or conditions and any applicable Legal Requirements and the rights of Foundation Medicine, Inc. and its successors and assigns
(“Foundation Medicine”), Tenant may designate and mark (by virtue of signage reasonably approved by Landlord) at Tenant’s cost a portion of Tenant’s allocated parking spaces for visitor parking on a reserved basis
in locations to be reasonably agreed upon by Landlord and Tenant. 
 The parking spaces shall be subject to such reasonable rules and
regulations as may be in effect for the use of the parking garage/areas from time to time (including, without limitation, Landlord’s right, without additional charge to Tenant above the prevailing fair market rate for parking spaces, to
institute a valet or attendant-managed parking system) provided that access to the parking spaces by Tenant’s employees shall be on a 24/7 basis. Landlord shall not be liable to Tenant, and this Lease shall not be affected, if any parking
rights of Tenant hereunder are impaired by Applicable Law. Notwithstanding anything to the contrary contained herein, Landlord shall have the right to relocate the surface parking spaces to the following garages in order of priority: (1) the
CambridgeSide Galleria Parking Garage located at 100 CambridgeSide Place in Cambridge; (2) the First Street Garage located on Spring Street in Cambridge; and (3) the common parking facility that serves the buildings located at 350
Kendall Street, 650 East Kendall Street, 675 West Kendall Street, 500 Kendall Street and 350 3 rd Street (Watermark Cambridge), each located in Cambridge. If parking spaces are not available in such garages, then Landlord shall have the right to
relocate the surface parking spaces to an alternate public parking facility of comparable quality located no further than one third mile from the Project and located within the City of Cambridge. Tenant shall be responsible for the actual fee for
such offsite parking spaces which fee shall not to exceed the published parking rates for monthly parking for the respective parking garage from time to time and shall not include any mark-up of such fee by Landlord or the owner or operator of the
parking garage. 
 Within thirty (30) days after the Effective Date and each anniversary of the Lease Commencement Date, Tenant shall
provide Landlord written notice of the number of parking spaces allocated to Tenant that Tenant is committed to using each year. If the number of parking spaces requested by Tenant is less than the 28 garage spaces and 15 surface spaces allocated to
Tenant, then Landlord reserves the right to allocate the excess parking spaces to other occupants in the Building on monthly basis. Upon sixty (60) days notice from Tenant, Landlord shall arrange for such reallocated parking spaces to be
restored for Tenant’s non-exclusive use. 
 Tenant shall have no right to hypothecate or encumber the parking spaces, and shall not
sublet, assign, or otherwise transfer the parking spaces other than to employees of Tenant occupying the Premises or to a permitted transferee pursuant to Section 17 of this Lease. 

Tenant shall, at Tenant’s sole expense, for so long as the Parking and Traffic Demand Management Plan dated April 2008 as approved by the
City of Cambridge on April 28, 2008, including the conditions set forth in such approval (as amended from time to time, the “PTDM”), remains applicable to the Project, (i) offer to subsidize mass transit monthly
passes for all of its 

  
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employees; (ii) implement a Commuter Choice Program; (iii) discourage single-occupant vehicle use by its employees; (iv) promote alternative modes of transportation and use of
alternative work hours; (v) meet with Landlord and/or its representatives no more than quarterly to discuss transportation programs and initiatives; (vi) participate in annual surveys monitoring transportation programs and initiatives;
(vii) cooperate with Landlord in connection with transportation programs and initiatives promulgated pursuant to the PTDM; (viii) provide alternative work programs (such as telecommuting, flex-time and compressed work weeks) to its
employees in order to reduce traffic impacts in Cambridge during peak commuter hours; and (ix) otherwise cooperate with Landlord in encouraging employees to seek alternate modes of transportation. 

ARTICLE 8 
 UTILITIES;
SERVICES 
 8.1 Utilities; Services. Landlord shall provide, subject to the terms of this Section, hot and cold water
for restrooms, drinking and office kitchen purposes, sewer connection, heated and chilled water for the HVAC system serving the Premises, electricity in an amount at least equal to 12 watts per usable square foot, gas service for the HVAC system and
water for sprinklers (collectively, “Utilities”) as more particularly set forth in the Base Building Specifications. Landlord shall pay, as Operating Expenses or subject to Tenant’s reimbursement obligation, for all
Utilities used on the Premises, all maintenance charges for Utilities, and any storm sewer charges or other similar charges for Utilities imposed by any Governmental Authority or Utility provider, and any taxes, penalties, surcharges or similar
charges thereon. Utilities will be separately metered or charged directly to Tenant by the provider as provided in the Landlord/Tenant Matrix attached hereto as Exhibit F. Tenant shall pay directly to the Utility provider, prior to
delinquency, any separately metered Utilities and services which may be furnished to Tenant or the Premises during the Term. Tenant shall pay, as part of Operating Expenses, its share of all charges for jointly metered Utilities based upon
consumption, as reasonably determined by Landlord. No interruption or failure of Utilities, from any cause whatsoever other than Landlord’s negligence or willful misconduct, shall result in eviction or constructive eviction of Tenant,
termination of this Lease or the abatement of Rent. Tenant agrees to limit use of water and sewer with respect to Common Areas to normal restroom use. Tenant shall supply its own cleaning and rubbish removal service. Landlord at Landlord’s cost
shall supply a dumpster or compactor at the loading dock for Tenant’s use for the disposal of non-hazardous, non-controlled substances. 

8.2 Shafts and Risers. During the Term, Landlord grants to Tenant a non-exclusive license to use a portion (reasonably specified
by Landlord based on Tenant’s Plans and generally based on Tenant’s Share) of the Building risers and other Building communications pathways reasonably designated by Landlord (“Communications Pathways”) for the
installation, maintenance, operation, replacement and/or removal at Tenant’s sole expense of certain cables, conduits, innerducts and connecting hardware approved by Landlord (any such cables, conduits, innerducts and connecting hardware
installed within the Communications Pathways, as the same may be modified, altered or replaced during the Term, are collectively referred to herein as the “Connecting Cables”). Any such approvals shall be granted, and
installation performed, in accordance with the terms of Section 11 below. With respect to each cable placed in the Communications Pathways from and after the Execution Date, Tenant shall label such cable (at the floor of the Building where the
cable originates and the floor where such cable terminates and at 

  
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 each access point in between at which such cable is pulled) with identification information as reasonably
required by Landlord which shall be consistent with commercial practice in the Cambridge/Kendall Square submarket. Landlord makes no warranties or representations to Tenant as to the suitability of the Communications Pathways for the installation
and operation of the Connecting Cables and Tenant hereby accepts the same in their as is, where is condition with all faults on the date hereof, provided, however, Landlord shall ensure that such Communications Pathways are dry and free of
interference from electrical cables and other base building devices likely to interfere with the operation of such Connecting Cables. In the event that at any time during the Term, Landlord reasonably determines, that the operation and/or periodic
testing of the Connecting Cables interferes with the operation of the Building or the business operations of any of the occupants of the Building, then Tenant shall, upon reasonable notice from Landlord attempt to correct such interference in
accordance with commercially reasonable approaches. Tenant is expressly forbidden to serve other tenants or occupants of the Building, to serve any locations outside the Building, or to resell any communications services without the prior written
consent of Landlord, which consent may be granted in Landlord’s sole discretion. Upon the expiration or earlier termination of this license, Tenant shall remove the Connecting Cables from the Communications Pathways and restore any damage to
the Building related to the removal of the Connecting Cables caused by Tenant, which obligations shall survive the expiration or earlier termination of this Lease. In addition, Landlord may, upon reasonable prior written notice (which notice shall
not be required in the event of an emergency), suspend this license and/or relocate the Connecting Cables in the event of any repair or construction affecting the Communications Pathways, provided, however, prior to making any such repair or
construction, Landlord shall ensure that Tenant has an alternative means of communicating in a manner consistent with the operation and standards of the Connecting Cables at the time of such license suspension and at Landlord’s sole cost and
expense. After the completion of such repair and/or construction, this license shall be reinstated with such reasonable modifications as Landlord may require and for which Landlord shall reimburse Tenant to ensure consistency with the new use of the
Communications Pathways. Subject to earlier termination pursuant to the provisions of this Section, this license shall be coterminous with the Lease. 

8.3 Rooftop Premises. During the Term, Tenant shall have the right to use a portion of the rooftop of the Building reasonably
designated by Landlord (the “Rooftop Premises”) at no additional rental cost for the installation of HVAC equipment, antennas, satellite dishes or other communications device and certain mechanical devices necessary for the
operation of Tenant’s business in the Premises, all of which shall have been approved by Landlord (any devices and/or equipment installed within the Rooftop Premises, as the same may be modified, altered or replaced during the Term, is
collectively referred to herein as “Tenant’s Rooftop Equipment”). Landlord’s approval of such devices and/or equipment shall not be unreasonably withheld, conditioned or delayed provided Tenant demonstrates to
Landlord’s reasonable satisfaction that the proposed devices and/or equipment (i) do not interfere with any base building equipment operated by Landlord on the roof; (ii) will not affect the structural integrity of the Building or
void the warranty for the roof or the roof membrane; (iii) shall be adequately screened so as to minimize the visibility of such devices and/or equipment; and (iv) shall be adequately sound-proofed to meet all requirements of Legal
Requirements. Tenant shall not install or operate Tenant’s Rooftop Equipment until Tenant has obtained and submitted to Landlord copies of all required governmental permits, licenses, and authorizations necessary for the installation and
operation thereof. In addition, Tenant shall comply with all reasonable construction rules and regulations 

  
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promulgated by Landlord in connection with the installation, maintenance and operation of Tenant’s Rooftop Equipment. Landlord shall provide reasonable utility service (at Tenant’s
reasonable cost) to the Rooftop Premises or to Tenant’s Rooftop Equipment. Tenant shall be responsible for the cost of repairing and maintaining Tenant’s Rooftop Equipment in good order, condition and repair and for the cost of repairing
any damage to the Building, or the cost of any necessary improvements to the Building, caused by or as a result of the installation, replacement and/or removal of Tenant’s Rooftop Equipment. Landlord makes no warranties or representations to
Tenant as to the suitability of the Rooftop Premises for the installation and operation of Tenant’s Rooftop Equipment. Tenant shall use Landlord’s roof contractor (if such roof is under warranty by such contractor) or another contractor
reasonably acceptable to Landlord for any work impacting the roof or roof membrane. If Tenant’s Rooftop Equipment damages the roof (other than ordinary wear and tear damage or damage arising from extraordinary events of a nature not
controllable by Tenant such as high winds, fire, electrical storms and the like) or invalidates or adversely affects any warranty, Tenant shall be fully responsible for the cost of repairs directly related and limited to the damage caused by
Tenant’s Rooftop Equipment (and any subsequent repairs to the roof to the extent that any warranty is invalidated or adversely affected). Except as set forth in the next sentence, Landlord shall elect, at the time of Landlord’s approval
thereof, either to require Tenant to convey to Landlord, in consideration of Ten Dollars ($10.00), all of Tenant’s right, title and interest in and to all or any portion of Tenant’s Rooftop Equipment or to remove such Tenant’s Rooftop
Equipment or a portion thereof at the expiration or sooner termination of the Term. Notwithstanding the foregoing, unless this Lease has been terminated due to a Default by Tenant, Tenant may remove Tenant’s satellite dishes and generators and
equipment appurtenant thereto at the expiration of the Term at Tenant’s cost provided that Tenant complies with any reasonable requirements or conditions imposed by Landlord and that Tenant remains responsible for the cost of repairs directly
related and limited to the damage caused by the removal of such equipment. 
 8.4 Access. Subject to reasonable security
procedures that Landlord may institute from time to time to prevent unauthorized access to the Building, Tenant shall have access to the Premises, the Rooftop Premises, the Building garage and surface lot, the freight elevator and freight loading
dock, and any other appurtenant areas, twenty-four (24) hours per day, seven (7) days per week. A security card will be issued to all permitted Building occupants. An access card will be required for access to the Building between the
hours of 6:00 p.m. and 7:00 a.m. on weekdays and 24 hours a day on weekends. Landlord shall install a card key access system on the elevators providing Tenant with the ability to lock off any full floors that it occupies. 

ARTICLE 9 

ALTERATIONS 
 9.1
Alterations and Tenant’s Property. Any alterations, additions, or improvements made to the Premises by or on behalf of Tenant, including additional locks or bolts of any kind or nature upon any doors or windows in the Premises, but
excluding installation, removal or realignment of furniture systems (other than removal of furniture systems owned or paid for by Landlord) not involving any modifications to the structure or connections (other than by ordinary plugs or jacks) to
Building Systems (as defined in Section 10.1 ) (“Alterations”), shall be subject to Landlord’s prior written consent, which may be given or withheld in Landlord’s sole discretion if any such
Alteration affects the structure or Building Systems and shall not be otherwise unreasonably withheld, conditioned or delayed. If Landlord approves any Alterations, Landlord 

  
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may impose such reasonable conditions on Tenant in connection with the commencement, performance and completion of such Alterations as Landlord may deem appropriate in Landlord’s sole and
absolute discretion. However, Landlord’s consent shall not be required for any Alterations that (a) are not visible from the exterior of the Building; (b) will not adversely affect the Building Systems or structural elements; and
(c) either are of a cosmetic nature such as painting, wallpapering, hanging pictures and installing carpeting, or cost less than $50,000 in any one instance. Any request for approval shall be in writing, delivered not less than 15 Business Days
in advance of any proposed construction, and accompanied by plans, specifications, bid proposals, work contracts and such other information concerning the nature and cost of the alterations as may be reasonably requested by Landlord, including the
identities and mailing addresses of all persons performing work or supplying materials. Landlord’s right to review plans and specifications and to monitor construction shall be solely for its own benefit, and Landlord shall have no duty to
ensure that such plans and specifications or construction comply with applicable Legal Requirements. Tenant shall cause, at its sole cost and expense, all Alterations to comply with insurance requirements and with Legal Requirements and shall
implement at its sole cost and expense any alteration or modification required by Legal Requirements as a result of any Alterations. Landlord shall not charge Tenant any coordination, overhead or contractor supervision fees in connection with the
Alterations; provided, however that Landlord shall be reimbursed for any reasonable third-party, out of pocket expenses incurred by Landlord in connection with the review and approval of the Alterations. Before Tenant begins any Alteration, Landlord
may post on and about the Premises notices of non-responsibility pursuant to applicable law. Tenant shall reimburse Landlord for, and indemnify and hold Landlord harmless from, any expense incurred by Landlord by reason of faulty work done by Tenant
or its contractors, delays caused by such work, or inadequate cleanup. The construction of Tenant’s Work shall be governed by the provisions contained in Section 5.2, and not the provisions of this Article 9. 

Upon Landlord’s request, Tenant shall furnish security or make other arrangements satisfactory to Landlord to assure payment for the
completion of all Alterations work free and clear of liens, and shall provide (and cause each contractor or subcontractor to provide) certificates of insurance for workers’ compensation and other coverage in amounts and from an insurance
company satisfactory to Landlord protecting Landlord against liability for personal injury or property damage during construction. Upon completion of any Alterations, Tenant shall deliver to Landlord: (i) sworn statements setting forth the
names of all contractors and subcontractors who did the work and final lien waivers from all such contractors and subcontractors; and (ii) “as built” plans for any such Alteration. 

Except for Removable Installations (as hereinafter defined), all Installations (as hereinafter defined) shall be and shall remain the property
of Landlord during the Term and following the expiration or earlier termination of the Term, shall not be removed by Tenant at any time during the Term, and shall remain upon and be surrendered with the Premises as a part thereof. Notwithstanding
the foregoing, Landlord may, at the time its approval of any such Installation is requested, notify Tenant that Landlord requires that Tenant remove such Installation upon the expiration or earlier termination of the Term, in which event Tenant
shall remove such Installation in accordance with the immediately succeeding sentence. Upon the expiration or earlier termination of the Term, Tenant shall remove (i) Connecting Cable as required in Section 8.2, (ii) any Installations
for which Landlord has given Tenant notice of removal in accordance with the immediately preceding sentence, and (iii) all of Tenant’s Property (as hereinafter defined), and 

  
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Tenant shall restore and repair any damage caused by or occasioned as a result of such removal, including, without limitation, capping off all such connections behind the walls of the Premises
and repairing any holes. During any restoration period beyond the expiration or earlier termination of the Term, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant. Landlord hereby waives any lien
or other interest in any of Tenant’s Property and Removable Installations and shall confirm such waiver in a form reasonably acceptable to Landlord and Tenant provided that Landlord shall be paid for Landlord’s reasonable out of pocket
expenses in connection with the waiver process. 
 For purposes of this Lease, (x) “Removable Installations”
means any Installations that Tenant desires to have removed from the Premises at the expiration or earlier termination of the Term which Landlord agrees in writing may be removed by Tenant, (y) “Tenant’s Property”
means Removable Installations and, other than Installations, any personal property or equipment of Tenant that may be removed without material damage to the Premises, and (z) “Installations” means all property of any
kind paid for by Landlord, all Alterations, all fixtures, and all partitions, hardware, built-in machinery, built-in casework and cabinets and other similar additions, equipment, property and improvements built into the Premises so as to become an
integral part of the Premises, including, without limitation, fume hoods which penetrate the roof or plenum area, built-in cold rooms, built-in warm rooms, walk-in cold rooms, walk-in warm rooms, deionized water systems, glass washing equipment,
autoclaves, chillers, built-in plumbing, electrical and mechanical equipment and systems, and any power generator and transfer switch. 

ARTICLE 10 
 REPAIRS
AND MAINTENANCE 
 10.1 Landlord’s Repairs. Landlord, as an Operating Expense subject to the provisions of
Section 4.5 hereof, shall maintain all of the structural, exterior, parking and other Common Areas of the Project, including roof, HVAC, plumbing, fire sprinklers, elevators and all other building systems serving the Premises and other portions
of the Project (“Building Systems”), in good repair, comparable to other first class lab research buildings in the Kendall Square area and in compliance with all applicable Legal Requirements, reasonable wear and tear and
uninsured losses and damages and damage caused by Tenant, or by any of Tenant’s agents, servants, employees, invitees and contractors (collectively, “Tenant Parties”) excluded. Losses and damages caused by Tenant or any
Tenant Party shall be repaired by Landlord, to the extent not covered by insurance, at Tenant’s sole cost and expense. Landlord reserves the right to stop Building Systems services when necessary (i) by reason of accident or emergency, or
(ii) for planned repairs, alterations or improvements, which are, in the judgment of Landlord, desirable or necessary to be made, until said repairs, alterations or improvements shall have been completed. Landlord shall have no responsibility
or liability for failure to supply Building Systems services during any such period of interruption; provided, however, that Landlord shall, except in case of emergency, give Tenant 24 hours advance notice of any planned stoppage of
Building Systems services for routine maintenance, repairs, alterations or improvements. Tenant shall promptly give Landlord written notice of any repair required by Landlord pursuant to this Section, after which Landlord shall make a commercially
reasonable effort to effect such repair. Landlord shall not be liable for any failure to make any repairs or to perform any maintenance unless such failure shall persist for an unreasonable time after Tenant’s written notice of the need for
such repairs or maintenance but in no event not later than thirty (30) days after receipt of such notice, or such longer time as is 

  
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reasonably necessary if more than 30 days are reasonably required to complete such repairs so long as Landlord commences such repairs within such 30 day period and thereafter diligently attempts
to complete the same. Tenant waives its rights under any state or local law to terminate this Lease or to make such repairs at Landlord’s expense and agrees that the parties’ respective rights with respect to such matters shall be solely
as set forth herein. Repairs required as the result of fire, earthquake, flood, vandalism, war, or similar cause of damage or destruction shall be controlled by Section 14.1. 

10.2 Tenant’s Repairs. Subject to Section 10.1 hereof, Tenant, at its expense, shall repair, replace and
maintain in good condition all portions of the Premises, including, without limitation, entries, doors, ceilings, interior windows, interior walls, and the interior side of demising walls, reasonable wear and tear and damage by fire or other
casualty excepted. Such repair and replacement may include capital expenditures and repairs whose benefit may extend beyond the Term. Should Tenant fail to make any such repair or replacement or fail to maintain the Premises, Landlord shall give
Tenant notice of such failure. If Tenant fails to commence cure of such failure within 30 days of Landlord’s notice, and thereafter diligently prosecute such cure to completion, Landlord may perform such work and shall be reimbursed by Tenant
within 30 days after demand therefor; provided, however, that if such failure by Tenant creates or could create an emergency, Landlord may immediately commence cure of such failure and shall thereafter be entitled to recover the costs of such cure
from Tenant. Subject to Articles 13 and 14, Tenant shall bear the full uninsured cost of any repair or replacement to any part of the Project that results from damage caused by Tenant or any Tenant Party and any repair that benefits only the
Premises. 
 ARTICLE 11 

MECHANIC’S LIENS 

11.1 Mechanic’s Liens. Tenant shall discharge, by bond or otherwise, any mechanic’s lien filed against the Premises or
against the Project for work claimed to have been done for, or materials claimed to have been furnished to, Tenant within 10 Business Days after written notice of the filing thereof, at Tenant’s sole cost and shall otherwise keep the Premises
and the Project free from any liens arising out of work performed, materials furnished or obligations incurred by Tenant. Should Tenant fail to discharge any lien described herein, Landlord shall have the right, but not the obligation, to pay such
claim or post a bond or otherwise provide security to eliminate the lien as a claim against title to the Project and the cost thereof shall be immediately due from Tenant as Additional Rent. If Tenant shall lease or finance the acquisition of office
equipment, furnishings, or other personal property of a removable nature utilized by Tenant in the operation of Tenant’s business, Tenant warrants that any Uniform Commercial Code Financing Statement filed as a matter of public record by any
lessor or creditor of Tenant will upon its face or by exhibit thereto indicate that such Financing Statement is applicable only to removable personal property of Tenant located within the Premises. In no event shall the address of the Project be
furnished on the statement without qualifying language as to applicability of the lien only to removable personal property, located in an identified suite held by Tenant. 

  
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 ARTICLE 12 

INDEMNIFICATION 

12.1 Indemnification. Tenant hereby indemnifies and agrees to defend, save and hold Landlord harmless from and against any and
all demands, claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses incurred in investigating or resisting the same (including, without limitation, reasonable attorneys’ fees,
charges and disbursements and costs of suit) (collectively, “Claims”) for injury or death to persons or damage to property (a) occurring within the Premises, or (b) occurring outside of the Premises and caused by
the negligence or willful misconduct of Tenant, or (c) arising from a breach or default by Tenant in the performance of any of its obligations hereunder, in all cases unless caused solely by the willful misconduct or negligence of Landlord or
Landlord’s agents, servants, employees, and contractors. Landlord shall not be liable to Tenant for, and Tenant assumes all risk of damage to, personal property (including, without limitation, loss of records kept within the Premises), unless
caused solely by the willful misconduct or negligence of Landlord or Landlord’s agents, servants, employees, and contractors, but subject to waiver of claims and subrogation provisions of Article 13. Tenant further hereby irrevocably waives any
and all Claims for injury to Tenant’s business or loss of income relating to any such damage or destruction of personal property (including, without limitation, any loss of records). Landlord shall not be liable for any damages arising from any
act, omission or neglect of any tenant in the Project or of any other third party. 
 The provisions of this Section 12.1 shall survive
the expiration or earlier termination of this Lease. 
 ARTICLE 13 

INSURANCE 
 13.1
Insurance. (a) Tenant shall not conduct or permit to be conducted any activity, or place any equipment in or about the Premises or the Building which will in any way increase the rate of fire insurance or other insurance on the
Building pertaining to the Permitted Use in compliance with the terms of the Lease provided that the Hazardous Materials List (defined in Section 21.2) does not change. If any increase in the rate of fire insurance or other insurance is stated
by any insurance company to be due to any activity or equipment of Tenant in or about the Premises or the Building, such statement shall be conclusive evidence that the increase in such rate is due to such activity or equipment and, as a result
thereof, Tenant shall be liable for the amount of such increase. Tenant shall reimburse Landlord for such amount upon written demand from Landlord and such sum shall be considered additional rent payable hereunder. 

(b) Landlord shall insure the Building, other than Tenant’s Work and Alterations (including improvements and betterments which
shall be Tenant’s obligation to insure), against loss due to fire and other casualties included in standard extended coverage insurance policies in an amount equal to ninety percent (90%) of the replacement cost thereof (with a waiver of
co-insurance), exclusive of architectural and engineering fees, excavations, footings and foundations. Throughout the Lease Term, Landlord shall maintain commercial general liability insurance (written on an occurrence basis) covering the
Project. Such insurance shall need not cover (a) Tenant’s furniture, fixtures, equipment or other personal property of Tenant on the Premises, or (b) any portion of the Tenant’s Work. 

  
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 (c) Commencing on the Lease Commencement Date and throughout the Lease Term, Tenant shall
obtain and maintain (1) commercial general liability insurance (written on an occurrence basis) including coverage provided in the current Insurance Services Office commercial general liability policy form insuring the indemnification
obligations assumed by Tenant under this lease to the extent they are insurable, premises and operations coverage, containing an endorsement for personal injury, (2) all-risk property insurance, or its equivalent (with flood and earthquake
coverage at Tenant’s option), (3) business interruption insurance (in an amount not less than the Base Rent and Additional Rent then in effect during any year), (4) comprehensive automobile liability insurance (covering any
automobiles owned or operated by Tenant, if any), (5) worker’s compensation insurance, (6) during all periods alcoholic beverages are dispensed or sold by Tenant at the Building or the Premises, liquor liability insurance or host
liquor liability insurance as the case may be, (7) employer’s liability insurance, and (8) such additional insurance relating to Tenant’s use and storage of Hazardous Materials as may be necessary to comply with any requirement
of any Governmental Authority. Such commercial general liability insurance shall be in an amount (which may include umbrella liability insurance) of no less than Two Million Dollars ($2,000,000) combined single limit per occurrence with a Three
Million Dollar ($3,000,000) annual aggregate. Such property insurance shall be in an amount not less than that required to replace all of Tenant’s Work and Alterations (including improvements and betterments) and all other contents of the
Tenant on the Premises (including, without limitation, Tenant’s trade fixtures, decorations, furnishings, equipment and personal property). Such automobile liability insurance shall be in an amount not less than One Million Dollars
($1,000,000) for each accident. Such worker’s compensation insurance shall carry minimum limits as defined by the law of the jurisdiction in which the Building is located (as the same may be amended from time to time). Such
employer’s liability insurance shall be in an amount not less than Five Hundred Thousand Dollars ($500,000) for each accident, Five Hundred Thousand Dollars ($500,000) disease-policy limit, and Five Hundred Thousand Dollars ($500,000)
disease-each employee. 
 (d) All such insurance required of Tenant under this Section shall: (1) be issued by a company
that is licensed to do business in the jurisdiction in which the Building is located and that has a rating equal to or exceeding A:VII from Best’s Insurance Guide; (2) in the case of the commercial general liability insurance, name as
additional insureds, the Landlord and the Landlord’s managing agent of the Building and if required by Landlord’s lender, the holder of any mortgage will be added as additional insured upon request by Landlord; (3) in the case of the
all-risk property insurance and business interruption insurance, provide that the insurer thereunder waives all right of recovery by way of subrogation against Landlord, its partners, employees and mortgage holder where required in writing prior to
a loss, in connection with any loss or damage covered by Tenant’s property policy; (4) be reasonably acceptable in form and content to Landlord if not on customary industry form and content; (5) be primary and noncontributory;
(6) to the extent obtainable, tenant’s insurer will endeavor to provide to Landlord, 30 days prior written notice of cancellation (with an exception of 10 days for non-payment of premium); however Tenant agrees to provide notice to
Landlord as soon as they are aware of such cancellation from their carriers; and (7) not contain any deductible provision that is not commercially reasonable unless such provision is first approved in writing by Landlord (provided that
Tenant’s deductible of $25,000 as of the Effective Date is deemed approved). Landlord may, from time to time, require Tenant to obtain additional insurance if such request is reasonable and customary with insurance requirements of other similar
tenants in the same geographic region, or if Landlord’s Lender requires a change to comply with loan requirements. Tenant shall provide certificates of insurance evidencing all required coverage prior to commencement of Tenant’s Work and
annually during the term of the lease prior to each policy expiration. Tenant shall also agree to provide full copies of actual policies upon written request from Landlord. Landlord may defer commencement of the Tenant’s Work pending delivery
of evidence of insurance. 

  
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 (e) Tenant hereby waives and releases Landlord and the holder of any mortgage from any and
all liabilities, claims and losses for damage to property for which Landlord is or may otherwise be held liable to the extent Tenant either is required to maintain property insurance pursuant to this Article with respect to the property so damaged,
or receives insurance proceeds on account thereof. Landlord hereby waives and releases Tenant from any and all liabilities, claims and losses for damage to property for which Tenant is or may be otherwise held liable to the extent Landlord either is
required to maintain property insurance pursuant to this Article with respect to the property so damaged, or receives insurance proceeds on account thereof. In the case of the all-risk property insurance, both parties shall secure waiver of
subrogation endorsements from their respective insurance carriers as to the other party. 
 ARTICLE 14 

RESTORATION 

14.1 Restoration. If, at any time during the Term, the Project or the Premises are damaged or destroyed by a fire or other
insured casualty, Landlord shall notify Tenant within 30 days after discovery of such damage as to the amount of time Landlord reasonably estimates it will take to restore the Project or the Premises, as applicable (the “Restoration
Period”). If the Restoration Period is reasonably estimated to exceed 9 months (the “Maximum Restoration Period”), Landlord may, in such notice, elect to terminate this Lease as of the date that is 45 days after
the date of discovery of such damage or destruction. If Landlord, in such notice, does not elect to terminate this Lease, and the restoration will exceed the Maximum Restoration period, Tenant may terminate this Lease by providing Landlord with
notice of such election to terminate this Lease within five (5) Business Days of Tenant’s receipt of such notice. Unless Landlord or Tenant, as the case may be, so elects to terminate this Lease, Landlord shall, subject to receipt of
sufficient insurance proceeds (with any deductible to be treated as a current Operating Expense), promptly restore the Premises (including Landlord’s Work and Tenant’s Work, but excluding the improvements installed by Tenant or by Landlord
and paid for by Tenant), subject to delays arising from the collection of insurance proceeds, from Force Majeure events or as needed to obtain any license, clearance or other authorization of any kind required to enter into and restore the Premises
issued by any Governmental Authority having jurisdiction over the use, storage, handling, treatment, generation, release, disposal, removal or remediation of Hazardous Materials in, on or about the Premises (collectively referred to herein as
“Hazardous Materials Clearances”); provided, however, that if repair or restoration of the Premises is not substantially complete as of the end of the Maximum Restoration Period or, if longer, the Restoration Period, Landlord
may, in its sole and absolute discretion, elect not to proceed with such repair and restoration, in which event Landlord shall be relieved of its obligation to make such repairs or restoration and this Lease shall terminate as of the date that is 75
days after the later of: (i) discovery of such damage or destruction, or (ii) the date all required Hazardous Materials Clearances are obtained, but Landlord shall retain any Rent paid and the right to any Rent payable by Tenant prior to
such election by Landlord. 

  
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 Tenant, at its expense, shall promptly perform, subject to delays arising from the collection of
insurance proceeds, from Force Majeure (as defined in Section 30.20) events or to obtain Hazardous Material Clearances, all repairs or restoration not required to be done by Landlord and shall promptly re-enter the Premises and commence
doing business in accordance with this Lease. 
 Notwithstanding the foregoing, either party may terminate this Lease if the Premises are
damaged during the last year of the Term and Landlord reasonably estimates that it will take more than two months to repair such damage, or if insurance proceeds are not available for such restoration. Rent shall be abated from the date all required
Hazardous Material Clearances are obtained until the Premises are repaired and restored, in the proportion which the area of the Premises, if any, which is not usable by Tenant bears to the total area of the Premises, unless Landlord provides Tenant
with other space during the period of repair that is suitable for the temporary conduct of Tenant’s business. Such abatement shall be the sole remedy of Tenant, and except as provided in this Section, Tenant waives any right to terminate the
Lease by reason of damage or casualty loss. 
 The provisions of this Lease, including this Section, constitute an express agreement between
Landlord and Tenant with respect to any and all damage to, or destruction of, all or any part of the Premises, or any other portion of the Project, and any statute or regulation which is now or may hereafter be in effect shall have no application to
this Lease or any damage or destruction to all or any part of the Premises or any other portion of the Project, the parties hereto expressly agreeing that this Section sets forth their entire understanding and agreement with respect to such matters.

 ARTICLE 15 

CONDEMNATION 

15.1 Condemnation. If the whole or any material part of the Premises or the Project is taken for any public or quasi-public use
under governmental law, ordinance, or regulation, or by right of eminent domain, or by private purchase in lieu thereof (a “Taking” or “Taken”), and the Taking would in Landlord’s reasonable
judgment, either prevent or materially interfere with Tenant’s use of the Premises or materially interfere with or impair Landlord’s ownership or operation of the Project, then upon written notice by Landlord this Lease shall terminate and
Rent shall be apportioned as of said date. In addition, if a Taking of the whole or any material part of the Premises or the Project would in the reasonable judgment of Tenant either prevent or materially interfere with Tenant’s use of the
Premises, Tenant shall have the right to terminate this Lease by written notice to Landlord within thirty (30) days of the date that Landlord’s title has been divested of such property. If part of the Premises shall be Taken, and this
Lease is not terminated as provided above, Landlord shall promptly restore the Premises and the Project as nearly as is commercially reasonable under the circumstances to their condition prior to such partial Taking and the rentable square footage
of the Building, the rentable square footage of the Premises, Tenant’s Share of Operating Expenses and the Rent payable hereunder during the unexpired Term shall be reduced to such extent as may be fair and reasonable under the circumstances.
Upon any such Taking, Landlord shall be entitled to receive the entire price or award from any such Taking without any payment to Tenant, and Tenant hereby assigns to Landlord Tenant’s interest, if any, in such award. Tenant shall have the
right, to the extent that same shall not diminish Landlord’s award, to make a separate claim against the condemning authority (but not Landlord) for such 

  
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compensation as may be separately awarded or recoverable by Tenant for moving expenses and damage to Tenant’s trade fixtures, if a separate award for such items is made to Tenant. Tenant
hereby waives any and all rights it might otherwise have pursuant to any provision of state law to terminate this Lease upon a partial Taking of the Premises or the Project. 

ARTICLE 16 
 EVENTS OF
DEFAULT 
 16.1 Events of Default. Each of the following events shall be a default (“Default”)
by Tenant under this Lease: 
 (a) Payment Defaults. Tenant shall fail to pay any installment of Rent or any other payment
hereunder when due and such default shall continue for more than five (5) Business Days after written notice from Landlord. 
 (b)
Insurance. Any insurance required to be maintained by Tenant pursuant to this Lease shall be canceled or terminated or shall expire or shall be reduced or materially changed, or Landlord shall receive a notice of nonrenewal of any such
insurance and Tenant shall fail to replace such insurance at least 20 days before the expiration of the current coverage. 
 (c)
Abandonment. Tenant shall no longer conduct any of its business operations in the Premises. 
 (d) Improper
Transfer. Tenant shall assign, sublease or otherwise transfer all or any portion of Tenant’s interest in this Lease or the Premises except as expressly permitted herein, or Tenant’s interest in this Lease shall be attached,
executed upon, or otherwise judicially seized and such action is not released within 90 days of the action. 
 (e) Liens.
Tenant shall fail to discharge or otherwise obtain the release of any lien placed upon the Premises in violation of this Lease within 15 days after written notice from Landlord. 

(f) Insolvency Events. Tenant or any guarantor or surety of Tenant’s obligations hereunder shall: (A) make a general
assignment for the benefit of creditors; (B) commence any case, proceeding or other action seeking to have an order for relief entered on its behalf as a debtor or to adjudicate it a bankrupt or insolvent, or seeking reorganization,
arrangement, adjustment, liquidation, dissolution or composition of it or its debts or seeking appointment of a receiver, trustee, custodian or other similar official for it or for all or of any substantial part of its property (collectively a
“ Proceeding for Relief”); (C) become the subject of any Proceeding for Relief which is not dismissed within 90 days of its filing or entry; or (D) die or suffer a legal disability (if Tenant, guarantor, or surety
is an individual) or be dissolved or otherwise fail to maintain its legal existence (if Tenant, guarantor or surety is a corporation, partnership or other entity). 

(g) Estoppel Certificate or Subordination Agreement. Tenant fails to execute any document required from Tenant under Article 18
or 19 within 5 Business Days after a second notice requesting such document. 

  
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 (h) Other Defaults. Tenant shall fail to comply with any provision of this Lease
other than those specifically referred to in this Section, and, except as otherwise expressly provided herein, such failure shall continue for a period of 30 days after written notice thereof from Landlord to Tenant. 

Any notice given pursuant to this Section hereof shall: (i) specify the alleged default, (ii) demand that Tenant cure such default,
(iii) be in lieu of, and not in addition to, or shall be deemed to be, any notice required under any provision of applicable law, and (iv) not be deemed a forfeiture or a termination of this Lease unless Landlord elects otherwise in such
notice; provided that if the nature of Tenant’s default pursuant to this Section is such that it cannot be cured by the payment of money and reasonably requires more than 30 days to cure, then Tenant shall not be deemed to be in default if
Tenant commences such cure within said 30 day period and thereafter diligently prosecutes the same to completion; provided, however, that such cure shall be completed no later than 90 days from the date of Landlord’s notice. 

16.2 Landlord’s Remedies. 

(a) Payment By Landlord; Interest. Upon a Default by Tenant hereunder, Landlord may, without waiving or releasing any obligation
of Tenant hereunder, make such payment or perform such act. All sums so paid or incurred by Landlord, together with interest thereon, from the date such sums were paid or incurred, at the Default Rate, shall be payable to Landlord on demand as
Additional Rent. 
 (b) Late Payment Rent. Late payment by Tenant to Landlord of Rent and other sums due will cause Landlord
to incur costs not contemplated by this Lease, the exact amount of which will be extremely difficult and impracticable to ascertain. Such costs include, but are not limited to, processing and accounting charges and late charges which may be imposed
on Landlord under any Mortgage covering the Premises. Therefore, if any installment of Rent due from Tenant is not received by Landlord within 5 days after the date such payment is due, Tenant shall pay to Landlord an additional sum equal to 5% of
the overdue Rent as a late charge. The parties agree that this late charge represents a fair and reasonable estimate of the costs Landlord will incur by reason of late payment by Tenant. In addition to the late charge, Rent not paid when due shall
bear interest at the Default Rate from the 5th day after the date due until paid. 
 (c) Remedies. Upon the occurrence of a
Default, Landlord, at its option, without further notice or demand to Tenant, shall have in addition to all other rights and remedies provided in this Lease, at law or in equity, the option to pursue any one or more of the following remedies, each
and all of which shall be cumulative and nonexclusive, without any notice or demand whatsoever. 
 (i) Terminate this
Lease, or at Landlord’s option, Tenant’s right to possession only, in which event Tenant shall immediately surrender the Premises to Landlord, and if Tenant fails to do so, Landlord may, without prejudice to any other remedy which it may
have for possession or arrearages in rent, enter upon and take possession of the Premises in compliance with applicable Legal Requirements and expel or remove Tenant and any other person who may be occupying the Premises or any part thereof, without
being liable for prosecution or any claim for damages therefor unless such process is accomplished by Landlord in violation of applicable Legal Requirements; 

  
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 (ii) Upon any termination of this Lease, whether pursuant to the foregoing
subsection (i) or otherwise, Landlord may recover from Tenant the following: 
 (A) The worth at the time of
award of any unpaid Rent which has been earned at the time of such termination; plus 
 (B) The worth at the time of
award of the amount by which the unpaid Rent which would have been earned after termination until the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 

(C) The worth at the time of award of the amount by which the unpaid Rent for the balance of the Term after the time of
award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 
 (D) Any
other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its obligations under this Lease or which in the ordinary course of things would be likely to result therefrom, specifically
including, but not limited to, brokerage commissions and advertising expenses incurred, expenses of remodeling the Premises or any portion thereof for a new tenant, whether for the same or a different use, and any special concessions made to obtain
a new tenant; and 
 (E) At Landlord’s election, such other amounts in addition to or in lieu of the foregoing
as may be permitted from time to time by applicable law. 
 As used in the foregoing subsection (c)(ii) (A) and (B), the
“ worth at the time of award” shall be computed by allowing interest at the Default Rate. As used in subsection (c)(ii)(C) above, the “worth at the time of award” shall be computed by discounting such amount at the
discount rate of the Federal Reserve Bank of Boston at the time of award plus 1%. 
 (iii) Landlord may continue this
Lease in effect after Tenant’s Default and recover Rent as it becomes due (Landlord and Tenant hereby agreeing that Tenant has the right to sublet or assign hereunder, subject only to reasonable limitations). Accordingly, if Landlord does not
elect to terminate this Lease following a Default by Tenant, Landlord may, from time to time, without terminating this Lease, enforce all of its rights and remedies hereunder, including the right to recover all Rent as it becomes due. 

  
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 (iv) Intentionally Deleted. 

(v) Independent of the exercise of any other remedy of Landlord hereunder or under applicable law, upon the occurrence
of a monetary Default or Default pertaining to Tenant’s failure to comply with the requirements of Article 21, Landlord may conduct an environmental test of the Premises as generally described in Section 21.4 hereof, at
Tenant’s expense. 
 Notwithstanding anything to the contrary contained herein, in no event shall Tenant ever be liable to Landlord for
any special, indirect, consequential or punitive damages under this Lease except as may arise in connection with Tenant’s holding over of the Premises as set forth in Article 25. 

(d) Effect of Exercise. Exercise by Landlord of any remedies hereunder or otherwise available shall not be deemed to be an
acceptance of surrender of the Premises and/or a termination of this Lease by Landlord, it being understood that such surrender and/or termination can be effected only by the express written agreement of Landlord and Tenant. Any law, usage, or
custom to the contrary notwithstanding, Landlord shall have the right at all times to enforce the provisions of this Lease in strict accordance with the terms hereof; and the failure of Landlord at any time to enforce its rights under this Lease
strictly in accordance with same shall not be construed as having created a custom in any way or manner contrary to the specific terms, provisions, and covenants of this Lease or as having modified the same and shall not be deemed a waiver of
Landlord’s right to enforce one or more of its rights in connection with any subsequent default. A receipt by Landlord of Rent or other payment with knowledge of the breach of any covenant hereof shall not be deemed a waiver of such breach, and
no waiver by Landlord of any provision of this Lease shall be deemed to have been made unless expressed in writing and signed by Landlord. To the greatest extent permitted by law, Tenant waives all right of redemption in case Tenant shall be
dispossessed by a judgment or by warrant of any court or judge. Any reletting of the Premises or any portion thereof shall be on such terms and conditions as Landlord in its sole discretion may determine. Landlord shall not be liable for, nor shall
Tenant’s obligations hereunder be diminished because of, Landlord’s failure to relet the Premises or collect rent due in respect of such reletting or otherwise to mitigate any damages arising by reason of Tenant’s Default. 

ARTICLE 17 

ASSIGNMENT AND SUBLETTING 

17.1 General Prohibition. Without Landlord’s prior written consent which shall not be unreasonably withheld, conditioned or
delayed subject to and on the conditions described in this Section, Tenant shall not, directly or indirectly, voluntarily or by operation of law, assign this Lease or sublease the Premises or any part thereof or mortgage, pledge, or hypothecate its
leasehold interest or grant any concession or license within the Premises, and any attempt to do any of the foregoing shall be void and of no effect. 

17.2 Permitted Transfers. If Tenant desires to assign, sublease, hypothecate or otherwise transfer this Lease or sublet the
Premises other than pursuant to a Permitted Assignment (as defined below), then at least 15 Business Days, but not more than 45 Business Days, before the date Tenant desires the assignment or sublease to be effective (the “Assignment
Date”), Tenant shall give Landlord a notice (the “Assignment Notice”) containing such information about the 

  
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proposed assignee or sublessee, including the proposed use of the Premises and any Hazardous Materials proposed to be used, stored handled, treated, generated in or released or disposed of from
the Premises, the Assignment Date, any relationship between Tenant and the proposed assignee or sublessee, and all material terms and conditions of the proposed assignment or sublease, including a copy of any proposed assignment or sublease in its
final form, and such other information as Landlord may deem reasonably necessary or appropriate to its consideration whether to grant its consent. Landlord may, by giving written notice to Tenant within 10 Business Days after receipt of the
Assignment Notice: (i) grant such consent, or (ii) refuse such consent, in its reasonable discretion; or (iii) terminate this Lease with respect to the space described in the Assignment Notice as of the Assignment Date (an
“Assignment Termination”). Among other reasons, it shall be reasonable for Landlord to withhold its consent in any of these instances: (1) the proposed assignee or subtenant is a governmental agency; (2) in
Landlord’s reasonable judgment, the use of the Premises by the proposed assignee or subtenant would entail any Alterations that would substantially lessen the value of the leasehold improvements in the Premises, or would require substantially
increased services by Landlord; (3) in Landlord’s reasonable judgment, the proposed assignee or subtenant lacks the creditworthiness to support the financial obligations it will incur under the proposed assignment (4) in
Landlord’s reasonable judgment, the business of the proposed assignee or subtenant is inconsistent with the type and quality of the nature of the Building; (5) the use of the Premises by the proposed assignee or subtenant will violate any
applicable Legal Requirement; (6) Landlord has experienced previous defaults by or is in litigation with the proposed assignee or subtenant; or (7) the proposed assignee or subtenant is an existing tenant in the Building and Landlord has,
or within a reasonable time frame will have, vacant space of comparable size, or a prospective tenant with whom Landlord has been in negotiations within the previous six (6) months; or (8) if the assignment or subletting concerns more than
50% of the Premises, the net worth (as determined in accordance with generally accepted accounting principles) of the proposed assignee or subtenant is less than $10,000,000. If Landlord delivers notice of its election to exercise an Assignment
Termination, Tenant shall have the right to withdraw such Assignment Notice by written notice to Landlord of such election within 5 Business Days after Landlord’s notice electing to exercise the Assignment Termination. If Tenant withdraws such
Assignment Notice, this Lease shall continue in full force and effect. If Tenant does not withdraw such Assignment Notice, this Lease, and the term and estate herein granted, shall terminate as of the Assignment Date with respect to the space
described in such Assignment Notice. No failure of Landlord to exercise any such option to terminate this Lease, or to deliver a timely notice in response to the Assignment Notice, shall be deemed to be Landlord’s consent to the proposed
assignment, sublease or other transfer. Tenant shall reimburse Landlord for its reasonable, out of pocket costs in connection with its consideration of any Assignment Notice and/or its preparation or review of any consent documents (provided that
such expenses shall not exceed $5,000 in any one instance with respect to the approval of any assignments or sublets unless such assignment or sublease does not occur in the ordinary course of business (e.g. is in connection with a bankruptcy or
reorganization of tenant), involves additional documentation beyond Landlord’s customary form of consent or significant negotiation of the same, or Landlord provides unusual or extraordinary services in connection therewith). 

Notwithstanding the foregoing, Landlord’s consent to an assignment of this Lease or a subletting of any portion of the Premises to any
entity controlling, controlled by or under common control with Tenant (a “Control Permitted Assignment”) shall not be required, provided that Landlord shall have the right to approve the form of any such sublease or
assignment. In addition, 

  
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Tenant shall have the right to assign this Lease, upon prior written notice to Landlord but without obtaining Landlord’s prior written consent, to a corporation or other entity which is a
successor-in-interest to Tenant, by way of merger, consolidation or corporate reorganization, or by the purchase of all or substantially all of the assets or the ownership interests of Tenant provided that (i) such merger or consolidation, or
such acquisition or assumption, as the case may be, is for a good business purpose and not principally for the purpose of transferring the Lease, and (ii) the net worth (as determined in accordance with generally accepted accounting principles
(“GAAP”)) of the assignee is not less than the greater of the net worth (as determined in accordance with GAAP) of Tenant as of the date of this Lease or the date of Tenant’s most current quarterly or annual financial
statements, and (iii) such assignee shall agree in writing to assume all of the terms, covenants and conditions of this Lease arising after the effective date of the assignment (a “Corporate Permitted Assignment”).
Control Permitted Assignments and Corporate Permitted Assignments are hereinafter referred to as “Permitted Assignments.” 

Notwithstanding anything to the contrary in this Article, Tenant shall have the right to obtain financing from investors (including venture
capital funding and corporate partners) which invest in private companies or undergo a public offering which results in a change in control of Tenant without such change of control constituting an assignment under this Section requiring Landlord
consent, provided that (i) Tenant notifies Landlord in writing of the financing prior to the closing of the financing (or, if prohibited from so notifying Landlord by Legal Requirements or other contractual confidentiality obligations, then
promptly thereafter), and (ii) provided that in no event shall such financing result in a change in use of the Premises from the use contemplated by Tenant at the commencement of the Term. 

17.3 Additional Conditions. As a condition to any such assignment or subletting, whether or not Landlord’s consent is
required, Landlord may require: 
 (i) that any assignee or subtenant agree, in writing at the time of such assignment or subletting,
that if Landlord gives such party notice that Tenant is in Default under this Lease, such party shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments will be received by Landlord without any liability except to
credit such payment against those due under the Lease, and any such third party shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason; provided, however, in no event shall
Landlord or its successors or assigns be obligated to accept such attornment; and 
 (ii) A list of Hazardous Materials, certified by
the proposed assignee or sublessee to be true and correct, which the proposed assignee or sublessee intends to use, store, handle, treat, generate in or release or dispose of from the Premises, together with copies of all documents relating to such
use, storage, handling, treatment, generation, release or disposal of Hazardous Materials by the proposed assignee or subtenant in the Premises or on the Project, prior to the proposed assignment or subletting, including, without limitation:
permits; approvals; reports and correspondence; storage and management plans; plans relating to the installation of any storage tanks to be installed in or under the Project (provided, said installation of tanks shall only be permitted after
Landlord has given its written consent to do so, which consent may be withheld in Landlord’s sole and absolute discretion); and all closure plans or any other documents required by any and all federal, state and local Governmental Authorities
for any storage tanks 

  
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installed in, on or under the Project for the closure of any such tanks. Neither Tenant nor any such proposed assignee or subtenant is required, however, to provide Landlord with any portion(s)
of the such documents containing information of a proprietary nature which, in and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. 

17.4 No Release of Tenant, Sharing of Excess Rents. Notwithstanding any assignment or subletting, Tenant shall at all times
remain fully and primarily responsible and liable for the payment of Rent and for compliance with all of Tenant’s other obligations under this Lease. If the Rent due and payable by a sublessee or assignee (or a combination of the rental payable
under such sublease or assignment plus any bonus or other consideration therefor or incident thereto in any form) exceeds the sum of the rental payable under this Lease, (excluding however, any Rent payable under this Section) and actual and
reasonable brokerage fees, legal costs and any design or construction fees directly related to and required pursuant to the terms of any such sublease and any unamortized tenant improvement expenses paid by Tenant in excess of Landlord’s
Contribution) (“Excess Rent”), then Tenant shall be bound and obligated to pay Landlord as Additional Rent hereunder 50% of such Excess Rent within 10 days following receipt thereof by Tenant. If Tenant shall sublet the
Premises or any part thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all rent from any such subletting, and Landlord as assignee and as attorney-in-fact for Tenant,
or a receiver for Tenant appointed on Landlord’s application, may collect such rent and apply it toward Tenant’s obligations under this Lease; except that, until the occurrence of a Default, Tenant shall have the right to collect and
retain such rent. 
 17.5 No Waiver. The consent by Landlord to an assignment or subletting shall not relieve Tenant or any
assignees of this Lease or any sublessees of the Premises from obtaining the consent of Landlord to any further assignment or subletting nor shall it release Tenant or any assignee or sublessee of Tenant from full and primary liability under the
Lease. The acceptance of Rent hereunder, or the acceptance of performance of any other term, covenant, or condition thereof, from any other person or entity shall not be deemed to be a waiver of any of the provisions of this Lease or a consent to
any subletting, assignment or other transfer of the Premises. 
 17.6 Prior Conduct of Proposed Transferee. Notwithstanding any other
provision of this Section, if the proposed assignee or sublessee has operations in the Commonwealth of Massachusetts that are or have been subject to an enforcement order issued by any Governmental Authority and such operations are substantially
comparable to the operations proposed by the assignee or sublessee for the Premises in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any order related to
the failure to make a required reporting to any Governmental Authority) pertaining to a use similar to the Permitted Use, Landlord shall have the absolute right to refuse to consent to any assignment or subletting to any such party. 

ARTICLE 18 
 ESTOPPEL
CERTIFICATE 
 18.1 Estoppel Certificate. Tenant shall, within 10 Business Days of written notice from Landlord,
execute, acknowledge and deliver a statement to Landlord, or any prospective purchaser or lender, in writing (i) certifying that this Lease is unmodified and in full force and effect (or, if 

  
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modified, stating the nature of such modification and certifying that this Lease as so modified is in full force and effect) and the dates to which the rental and other charges are paid in
advance, if any, (ii) acknowledging whether or not any uncured defaults exist on the part of Landlord hereunder, or specifying such defaults if any are claimed, and (iii) setting forth such further information with respect to the status of
this Lease or the Premises as may be requested thereon. Any such statement may be relied upon by any prospective purchaser or encumbrancer of all or any portion of the real property of which the Premises are a part. Tenant’s failure to deliver
such statement within such time shall, at the option of Landlord, constitute a Default under this Lease, and, in any event, shall be conclusive upon Tenant that the Lease is in full force and effect and without modification except as may be
represented by Landlord in any certificate prepared by Landlord and delivered to Tenant for execution. Landlord shall, within 10 Business Days of written notice from Tenant, execute, acknowledge and deliver a comparable statement to Tenant. 

ARTICLE 19 

SUBORDINATION 

19.1 Subordination. This Lease and Tenant’s interest and rights hereunder are hereby made and shall be subject and
subordinate at all times to the lien of any Mortgage now existing or hereafter created on or against the Project or the Premises, and all amendments, restatements, renewals, modifications, consolidations, refinancing, assignments and extensions
thereof, provided that the Holder of such Mortgage delivers to Tenant a subordination, non-disturbance and attornment agreement on such holder’s standard and customary form provided that such holder is an institutional lender or investor.
Tenant agrees, at the election of the Holder of any such Mortgage, to attorn to any such Holder. Notwithstanding the foregoing, any such Holder may at any time subordinate its Mortgage to this Lease, without Tenant’s consent, by notice in
writing to Tenant, and thereupon this Lease shall be deemed prior to such Mortgage without regard to their respective dates of execution, delivery or recording and in that event such Holder shall have the same rights with respect to this Lease as
though this Lease had been executed prior to the execution, delivery and recording of such Mortgage and had been assigned to such Holder. The term “Mortgage” whenever used in this Lease shall be deemed to include deeds of
trust, security assignments and any other encumbrances, and any reference to the “Holder” of a Mortgage shall be deemed to include the beneficiary under a deed of trust. 

ARTICLE 20 
 SURRENDER

 20.1 Surrender. Upon the expiration of the Term or earlier termination of Tenant’s right of possession, Tenant
shall surrender the Premises to Landlord in the condition the Premises are required to be maintained during the Term, along with any Alterations or Installations permitted by Landlord to remain in the Premises pursuant to the provisions of this
Lease, free of Hazardous Materials brought upon, kept, used, stored, handled, treated, generated in, or released or disposed of from, the Premises by Tenant or any Tenant Party or subtenant (collectively, “Tenant HazMat
Operations”) and released of all Hazardous Materials Clearances, broom clean, ordinary wear and tear and casualty loss and condemnation covered by Sections 14 and 15 excepted. At least 3 months prior to the surrender of
the Premises, Tenant shall deliver to Landlord a narrative description of the actions proposed (or required by any Governmental Authority) to be taken by Tenant in order to surrender the Premises (including any Installations permitted by Landlord to


  
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remain in the Premises) at the expiration or earlier termination of the Term, free from any residual impact from the Tenant HazMat Operations and otherwise released for unrestricted use and
occupancy (the “Surrender Plan”). Such Surrender Plan shall be accompanied by a current listing of (i) all Hazardous Materials licenses and permits held by or on behalf of any Tenant Party with respect to the Premises,
and (ii) all Hazardous Materials used, stored, handled, treated, generated, released or disposed of from the Premises, and shall be subject to the review and approval of Landlord’s environmental consultant. In connection with the review
and approval of the Surrender Plan, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such additional non-proprietary information concerning Tenant HazMat Operations as Landlord shall request. On or before such
surrender, Tenant shall deliver to Landlord evidence that the approved Surrender Plan shall have been satisfactorily completed and Landlord shall have the right, subject to reimbursement at Tenant’s expense as set forth below, to cause
Landlord’s environmental consultant to inspect the Premises and perform such additional procedures as may be deemed reasonably necessary to confirm that the Premises are, as of the effective date of such surrender or early termination of the
Lease, free from any residual impact from Tenant HazMat Operations. Tenant shall reimburse Landlord, as Additional Rent, for the actual out-of pocket expense incurred by Landlord for Landlord’s environmental consultant to review and approve the
Surrender Plan and to visit the Premises and verify satisfactory completion of the same, which cost shall not exceed $5,000. Landlord shall have the unrestricted right to deliver such Surrender Plan and any report by Landlord’s environmental
consultant with respect to the surrender of the Premises to third parties. 
 If Tenant shall fail to prepare or submit a Surrender Plan
approved by Landlord, or if Tenant shall fail to complete the approved Surrender Plan, or if such Surrender Plan, whether or not approved by Landlord, shall fail to adequately address any residual effect of Tenant HazMat Operations in, on or about
the Premises, Landlord shall have the right to take such actions as Landlord may deem reasonable or appropriate to assure that the Premises and the Project are surrendered free from any residual impact from Tenant HazMat Operations, the cost of
which actions shall be reimbursed by Tenant as Additional Rent, without regard to the limitation set forth in the first paragraph of this Section. 

Tenant shall immediately return to Landlord all keys and/or access cards to parking, the Project, restrooms or all or any portion of the
Premises furnished to or otherwise procured by Tenant. If any such access card or key is lost, Tenant shall pay to Landlord, at Landlord’s election, either the cost of replacing such lost access card or key or the cost of reprogramming the
access security system in which such access card was used or changing the lock or locks opened by such lost key. Any Tenant’s Property, Alterations and property not so removed by Tenant as permitted or required herein shall be deemed abandoned
and may be stored, removed, and disposed of by Landlord at Tenant’s expense, and Tenant waives all claims against Landlord for any damages resulting from Landlord’s retention and/or disposition of such property. All obligations of Tenant
hereunder not fully performed as of the termination of the Term, including the obligations of Tenant under Article 21 hereof, shall survive the expiration or earlier termination of the Term, including, without limitation, indemnity obligations,
payment obligations with respect to Rent and obligations concerning the condition and repair of the Premises. 

  
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 ARTICLE 21 

ENVIRONMENTAL REQUIREMENTS 

21.1 Prohibition/Compliance/Indemnity. Tenant shall not cause or permit any Hazardous Materials (as hereinafter defined) to be
brought upon, kept, used, stored, handled, treated, generated in or about, or released or disposed of from, the Premises or the Project in violation of applicable Environmental Requirements (as hereinafter defined) by Tenant or any Tenant Party or
subtenant. If Tenant breaches the obligation stated in the preceding sentence, or if the presence of Hazardous Materials in the Premises is caused or permitted by Tenant or any Tenant Party during the Term or any holding over results in
contamination of the Premises, the Project or any adjacent property, or if contamination of the Premises, the Project or any adjacent property by Hazardous Materials brought into, kept, used, stored, handled, treated, generated in or about, or
released or disposed of from, the Premises by Tenant or any Tenant Party or subtenant otherwise occurs during the Term or any holding over, Tenant hereby indemnifies and shall defend and hold Landlord, its officers, directors, employees, agents and
contractors harmless from any and all actions (including, without limitation, remedial or enforcement actions of any kind, administrative or judicial proceedings, and orders or judgments arising out of or resulting therefrom), costs, claims, damages
(including, without limitation, punitive damages and damages based upon diminution in value of the Premises or the Project, or the loss of, or restriction on, use of the Premises or any portion of the Project), expenses (including, without
limitation, attorneys’, consultants’ and experts’ fees, court costs and amounts paid in settlement of any claims or actions), fines, forfeitures or other civil, administrative or criminal penalties, injunctive or other relief (whether
or not based upon personal injury, property damage, or contamination of, or adverse effects upon, the environment, water tables or natural resources), liabilities or losses (collectively, “Environmental Claims”) which arise
during or after the Term as a result of such contamination. This indemnification of Landlord by Tenant includes, without limitation, costs incurred in connection with any investigation of site conditions or any cleanup, treatment, remedial, removal,
or restoration work required by any federal, state or local Governmental Authority because of Hazardous Materials present in the air, soil or ground water above, on, or under the Premises. Without limiting the foregoing, if the presence of any
Hazardous Materials on the Premises, the Project or any adjacent property caused or permitted by Tenant or any Tenant Party results in any contamination of the Premises, the Project or any adjacent property, Tenant shall promptly take all actions at
its sole expense and in accordance with applicable Environmental Requirements as are necessary to return the Premises, the Project or any adjacent property to the condition existing prior to the time of such contamination, provided that
Landlord’s approval of such action shall first be obtained, which approval shall not unreasonably be withheld so long as such actions would not potentially have any material adverse long-term or short-term effect on the Premises or the Project.

 Notwithstanding anything to the contrary contained in this Section 20, Tenant shall not be responsible for, and the indemnification
and hold harmless obligation set forth in this paragraph shall not apply to (i) contamination in the Premises which existed in the Premises prior to the Commencement Date, or (ii) the presence of any Hazardous Materials in the Premises
which migrated from outside of the Premises into the Premises, or (iii) contamination caused by Landlord or any Landlord Party. 

  
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 21.2 Business. Landlord acknowledges that it is not the intent of this Section to
prohibit Tenant from using the Premises for the Permitted Use. Tenant may operate its business according to prudent industry practices so long as the use or presence of Hazardous Materials is strictly and properly monitored according to all then
applicable Environmental Requirements. As a material inducement to Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant agrees to deliver to Landlord prior to the Lease Commencement Date a list identifying each
type of Hazardous Materials to be brought upon, kept, used, stored, handled, treated, generated on, or released or disposed of from, the Premises and setting forth any and all governmental approvals or permits required in connection with the
presence, use, storage, handling, treatment, generation, release or disposal of such Hazardous Materials on or from the Premises (“Hazardous Materials List”). Tenant shall deliver to Landlord an updated Hazardous Materials
List at least once a year and shall also deliver an updated list before any new Hazardous Material is brought onto, kept, used, stored, handled, treated, generated on, or released or disposed of from, the Premises. Tenant shall deliver to Landlord
true and correct copies of the following documents (the “Haz Mat Documents”) relating to the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials prior to the Lease Commencement Date, or
if unavailable at that time, concurrent with the receipt from or submission to a Governmental Authority: permits; approvals; reports and correspondence; storage and management plans, notice of violations of any Legal Requirements; plans relating to
the installation of any storage tanks to be installed in the Project (provided, said installation of tanks shall only be permitted in compliance with the applicable Legal Requirements and subject to any reasonable conditions or requirements imposed
by Landlord); all closure plans or any other documents required by any and all federal, state and local Governmental Authorities for any storage tanks installed in, on or under the Project for the closure of any such tanks; and a Surrender Plan (to
the extent surrender in accordance with Article 20 cannot be accomplished in 3 months). Tenant is not required, however, to provide Landlord with any portion(s) of the Haz Mat Documents containing information of a proprietary nature which, in and of
themselves, do not contain a reference to any Hazardous Materials or hazardous activities. It is not the intent of this Section to provide Landlord with information which could be detrimental to Tenant’s business should such information become
possessed by Tenant’s competitors. 
 21.3 Tenant Representation and Warranty. Tenant hereby represents and warrants to
Landlord that (i) neither Tenant nor any of its legal predecessors has been required by any prior landlord, lender or Governmental Authority at any time to take remedial action in connection with Hazardous Materials contaminating a property
which contamination was permitted by Tenant of such predecessor or resulted from Tenant’s or such predecessor’s action or use of the property in question, and (ii) Tenant is not subject to any enforcement order issued by any
Governmental Authority in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any order related to the failure to make a required reporting to any Governmental
Authority). If Landlord determines that this representation and warranty was not true as of the date of this lease, Landlord shall have the right to terminate this Lease in Landlord’s sole and absolute discretion. 

21.4 Testing. If any Governmental Authority requires testing to determine whether any contamination of the Premises or the
Project has occurred as a result of Tenant’s use, then Landlord shall have the right to conduct such testing at Tenant’s expense. If Tenant conducts its own tests of the Premises using third party contractors and test procedures acceptable
to Landlord (and such Governmental Authority), which tests are certified to Landlord (and such Governmental Authority), Landlord shall accept such tests in lieu of the tests to be paid for by Tenant. In 

  
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addition, at any time, and from time to time, prior to the expiration or earlier termination of the Term, Landlord shall have the right to conduct appropriate tests of the Premises and the
Project to determine if contamination has occurred as a result of Tenant’s use of the Premises. In connection with such testing, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such non-proprietary information
concerning the use of Hazardous Materials in or about the Premises by Tenant or any Tenant Party. If contamination has occurred for which Tenant is liable under this Section, Tenant shall pay all costs to conduct such tests. If no such contamination
is found, Landlord shall pay the costs of such tests (which shall not constitute an Operating Expense). Landlord shall provide Tenant with a copy of all third party, non-confidential reports and tests of the Premises made by or on behalf of Landlord
during the Term without representation or warranty and subject to a confidentiality agreement. Tenant shall, at its sole cost and expense, promptly and satisfactorily remediate any environmental conditions identified by such testing for which Tenant
is responsible hereunder in accordance with all Environmental Requirements. Landlord’s receipt of or satisfaction with any environmental assessment in no way waives any rights which Landlord may have against Tenant. 

21.5 Control Areas. Tenant shall be allowed to utilize up to its pro rata share of the Hazardous Materials inventory within any
control area or zone (located within the Premises), as designated by the applicable building code, for chemical use or storage. As used in the preceding sentence, Tenant’s pro rata share of any control areas or zones located within the Premises
shall be determined based on the rentable square footage that Tenant leases within the applicable control area or zone. For purposes of example only, if a control area or zone contains 10,000 rentable square feet and 2,000 rentable square feet of a
tenant’s premises are located within such control area or zone (while such premises as a whole contains 5,000 rentable square feet), the applicable tenant’s pro rata share of such control area would be 20%. 

21.6 Intentionally Deleted. 

21.7 Tenant’s Obligations. Tenant’s obligations under this Section shall survive the expiration or earlier termination
of the Lease. any period of time after the expiration or earlier termination of this Lease required by Tenant or Landlord to complete the removal from the Premises of any Hazardous Materials (including, without limitation, the release and
termination of any licenses or permits restricting the use of the Premises and the completion of the approved Surrender Plan), Tenant shall continue to pay the full Rent in accordance with this Lease for any portion of the Premises not relet by
Landlord in Landlord’s sole discretion, which Rent shall be prorated daily. 
 21.8 Definitions. As used herein, the term
“Environmental Requirements” means all applicable present and future statutes, regulations, ordinances, rules, codes, judgments, orders or other similar enactments of any Governmental Authority regulating or relating to
health, safety, or environmental conditions on, under, or about the Premises or the Project, or the environment, including without limitation, the following: the Comprehensive Environmental Response, Compensation and Liability Act; the Resource
Conservation and Recovery Act; and all state and local counterparts thereto, and any regulations or policies promulgated or issued thereunder. As used herein, the term “Hazardous Materials” means and includes any substance,
material, waste, pollutant, or contaminant listed or defined as hazardous or toxic (other than reasonable amounts of routine cleaning products), or regulated by reason of its impact or potential impact on humans, 

  
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animals and/or the environment under any Environmental Requirements, asbestos and petroleum, including crude oil or any fraction thereof, natural gas liquids, liquefied natural gas, or synthetic
gas usable for fuel (or mixtures of natural gas and such synthetic gas). As defined in Environmental Requirements, Tenant is and shall be deemed to be the “operator” of Tenant’s “facility” and the
“owner” of all Hazardous Materials brought on the Premises by Tenant or any Tenant Party, and the wastes, by-products, or residues generated, resulting, or produced therefrom. 

ARTICLE 22 

TENANT’S REMEDIES/LIMITATION OF LIABILITY 

22.1 Tenant’s Remedies/Limitation of Liability. Landlord shall not be in default hereunder unless Landlord fails to perform
any of its obligations hereunder within 30 days after written notice from Tenant specifying such failure (unless such performance will, due to the nature of the obligation, require a period of time in excess of 30 days, then after such period of
time as is reasonably necessary, provided that Landlord shall diligently and continuously pursue such cure). Upon any default by Landlord, Tenant shall give notice by registered or certified mail to any Holder of a Mortgage covering the Premises and
to any landlord of any lease of property in or on which the Premises are located and Tenant shall offer such Holder and/or landlord a reasonable opportunity to cure the default, including time to obtain possession of the Project by power of sale or
a judicial action if such should prove necessary to effect a cure; provided Landlord shall have furnished in advance to Tenant in writing the names and addresses of all such persons who are to receive such notices. All obligations of Landlord
hereunder shall be construed as covenants, not conditions; and, except as may be otherwise expressly provided in this Lease, Tenant may not terminate this Lease for breach of Landlord’s obligations hereunder. 

All obligations of Landlord under this Lease arising or accruing during the period of such Landlord’s ownership of the Premises, and not
thereafter, will be binding upon Landlord. The term “Landlord” in this Lease shall mean only the owner for the time being of the Premises. Upon the transfer by such owner of its interest in the Premises, such owner shall thereupon be
released and discharged from all obligations of Landlord thereafter accruing, but such obligations shall be binding during the Term upon each new owner for the duration of such owner’s ownership. 

22.2 Limitation on Landlord’s Liability. NOTWITHSTANDING ANYTHING SET FORTH HEREIN OR IN ANY OTHER AGREEMENT BETWEEN
LANDLORD AND TENANT TO THE CONTRARY: (A) EXCEPT TO THE EXTENT ARISING AS A RESULT OF THE NEGLIGENCE OR WILLFUL MISCONDUCT OF LANDLORD OR ANY LANDLORD PARTY, LANDLORD SHALL NOT BE LIABLE TO TENANT OR ANY OTHER PERSON FOR (AND TENANT AND EACH
SUCH OTHER PERSON ASSUME ALL RISK OF) LOSS, DAMAGE OR INJURY, TO: TENANT’S PERSONAL PROPERTY OF EVERY KIND AND DESCRIPTION, INCLUDING, WITHOUT LIMITATION TRADE FIXTURES, EQUIPMENT, INVENTORY, SCIENTIFIC RESEARCH, SCIENTIFIC EXPERIMENTS,
LABORATORY ANIMALS, PRODUCT, SPECIMENS, SAMPLES, AND/OR SCIENTIFIC, BUSINESS, ACCOUNTING AND OTHER RECORDS OF EVERY KIND AND DESCRIPTION KEPT AT THE PREMISES AND ANY AND ALL INCOME DERIVED OR DERIVABLE THEREFROM; (B) THERE SHALL BE NO PERSONAL
RECOURSE TO LANDLORD FOR ANY ACT OR OCCURRENCE IN, ON OR ABOUT THE PREMISES OR ARISING IN ANY WAY UNDER THIS LEASE OR ANY OTHER 

  
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AGREEMENT BETWEEN LANDLORD AND TENANT WITH RESPECT TO THE SUBJECT MATTER HEREOF AND ANY LIABILITY OF LANDLORD HEREUNDER SHALL BE STRICTLY LIMITED SOLELY TO LANDLORD’S INTEREST IN THE PROJECT
OR ANY PROCEEDS FROM SALE OR CONDEMNATION THEREOF AND ANY INSURANCE PROCEEDS PAYABLE IN RESPECT OF LANDLORD’S INTEREST IN THE PROJECT OR IN CONNECTION WITH ANY SUCH LOSS; AND (C) IN NO EVENT SHALL ANY PERSONAL LIABILITY BE ASSERTED AGAINST
LANDLORD IN CONNECTION WITH THIS LEASE NOR SHALL ANY RECOURSE BE HAD TO ANY OTHER PROPERTY OR ASSETS OF LANDLORD OR ANY OF LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS. UNDER NO CIRCUMSTANCES SHALL LANDLORD OR ANY OF
LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS BE LIABLE FOR INJURY TO TENANT’S BUSINESS OR FOR ANY LOSS OF INCOME OR PROFIT THEREFROM. NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED HEREIN, IN NO EVENT SHALL LANDLORD
EVER BE LIABLE TO TENANT FOR ANY SPECIAL, INDIRECT, CONSEQUENTIAL OR PUNITIVE DAMAGES UNDER THIS LEASE 
 ARTICLE 23 

INSPECTION AND ACCESS 

23.1 Inspection and Access. Landlord and its agents, representatives, and contractors may enter the Premises during business
hours on not less than 48 hours advance written notice (except in the case of emergencies in which case no such notice shall be required and such entry may be at any time) for the purpose of making such repairs as may be required or permitted
pursuant to the Lease, inspecting the Premises, showing the Premises to prospective purchasers or lenders and, during the last year of the Term, to prospective tenants, and at any time during the Term for any other business purpose. Notwithstanding
the foregoing, Landlord acknowledges that the Premises may contain confidential proprietary information and research and laboratory experiments. Accordingly, Tenant may elect to have a Tenant representative accompany any such tours with prospective
purchasers, tenants or lenders. If Tenant does not so elect to have a representative accompany the tour within 24 hours after receiving Landlord’s notice, Tenant shall be deemed to have waiver such right. 

Landlord may grant easements, make public dedications, designate Common Areas and create restrictions pertaining to the Project, provided that
no such easement, dedication, designation or restriction materially, adversely affects Tenant’s use or occupancy of the Premises for the Permitted Use. At Landlord’s request, Tenant shall execute such instruments as may be necessary for
such easements, dedications or restrictions. Tenant shall at all times, except in the case of emergencies, have the right to escort Landlord or its agents, representatives, contractors or guests while the same are in the Premises, provided such
escort does not materially and adversely affect Landlord’s access rights hereunder 

  
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 ARTICLE 24 

SIGNAGE 
 24.1
Signs; Exterior Appearance. Tenant shall not, without the prior written consent of Landlord, which may be granted or withheld in Landlord’s sole but reasonable discretion: (i) attach any awnings, exterior lights, decorations,
balloons, flags, pennants, banners, painting or other projection to any outside wall of the Project, (ii) use any curtains, blinds, shades or screens other than Landlord’s standard window coverings, (iii) coat or otherwise sunscreen
the interior or exterior of any windows, (iv) place any bottles, parcels, or other articles on the window sills, (v) place any equipment, furniture or other items of personal property on any exterior balcony, or (vi) paint, affix or
exhibit on any part of the Premises or the Project any signs, notices, window or door lettering, placards, decorations, or advertising media of any type which can be viewed from the exterior of the Building. Landlord shall provide at Landlord’s
expense building standard signage in the lobby and at Tenant’s entrance. Notwithstanding the foregoing, if Tenant occupies the entire floor, Tenant may install at Tenant’s expense Tenant’s signage in the elevator lobby in a size and
location to be determined and subject to Landlord’s approval which will not be unreasonably withheld, conditioned or delayed. Notwithstanding the foregoing, provided that Tenant occupies at least the entire third floor, and subject to the
rights of Foundation Medicine, Tenant shall have a non-exclusive right to install at Tenant’s expense exterior signage on the Building façade in a location and with a design, size and operation subject to Landlord’s approval which
shall not be unreasonably conditioned, withheld or delayed, and subject to the applicable Legal Requirements of the City of Cambridge. Tenant shall be responsible for all costs relating to the permitting, installation and maintenance of the signage.
Tenant shall remove any such signage, and repair any damage caused by such removal, prior to the expiration or earlier termination of this Lease. 

ARTICLE 25 
 HOLDING
OVER 
 25.1 Holding Over. If, with Landlord’s express written consent, Tenant retains possession of the Premises
after the termination of the Term, (i) unless otherwise agreed in such written consent, such possession shall be subject to immediate termination by Landlord at any time, (ii) all of the other terms and provisions of this Lease shall
remain in full force and effect (excluding any expansion or renewal option or other similar right or option) during such holdover period, (iii) Tenant shall continue to pay Base Rent in the amount payable upon the date of the expiration or
earlier termination of this Lease, and (iv) all other payments shall continue under the terms of this Lease. If Tenant remains in possession of the Premises after the expiration or earlier termination of the Term without the express written
consent of Landlord, Tenant shall become a tenant at sufferance upon the terms of this Lease except that the monthly rental shall be equal to 150% of Base Rent in effect during the last 30 days of the Term, plus all other Additional Rent hereunder,
and Tenant shall be responsible for all damages suffered by Landlord resulting from or occasioned by Tenant’s holding over, including consequential damages. No holding over by Tenant, whether with or without consent of Landlord, shall operate
to extend this Lease except as otherwise expressly provided, and this Section shall not be construed as consent for Tenant to retain possession of the Premises. Acceptance by Landlord of Rent after the expiration of the Term or earlier termination
of this Lease shall not result in a renewal or reinstatement of this Lease. 

  
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 ARTICLE 26 

WAIVER OF JURY TRIAL 

26.1 Waiver of Jury Trial. TO THE EXTENT PERMITTED BY LAW, TENANT AND LANDLORD WAIVE ANY RIGHT TO TRIAL BY JURY OR TO HAVE A
JURY PARTICIPATE IN RESOLVING ANY DISPUTE, WHETHER SOUNDING IN CONTRACT, TORT, OR OTHERWISE, BETWEEN LANDLORD AND TENANT ARISING OUT OF THIS LEASE OR ANY OTHER INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN CONNECTION HEREWITH OR THE
TRANSACTIONS RELATED HERETO. 
 ARTICLE 27 

SECURITY DEPOSIT 

27.1 Security Deposit. Tenant shall deposit with Landlord, upon delivery of an executed copy of this Lease to Landlord, a
security deposit (the “Security Deposit”) for the performance of all of Tenant’s obligations hereunder in the amount set forth in Section 1.1 of this Lease, which Security Deposit shall be in the form
of an unconditional and irrevocable letter of credit (the “Letter of Credit”): (i) in form and substance satisfactory to Landlord, (ii) naming Landlord as beneficiary, (iii) expressly allowing Landlord to draw
upon it at any time from time to time by delivering to the issuer notice that Landlord is entitled to draw thereunder, (iv) issued by an FDIC-insured financial institution satisfactory to Landlord, (v) redeemable by presentation of a sight
draft in the state of Landlord’s choice, and (vi) transferable without fee or cost to Landlord. If Tenant does not provide Landlord with a substitute Letter of Credit complying with all of the requirements hereof at least 10 days before
the stated expiration date of any then current Letter of Credit, Landlord shall have the right to draw the full amount of the current Letter of Credit and hold the funds drawn in cash without obligation for interest thereon as the Security Deposit.
The Letter of Credit shall be held by Landlord as security for the performance of Tenant’s obligations under this Lease. The Letter of Credit is not an advance rental deposit or a measure of Landlord’s damages in case of Tenant’s
default. Upon each occurrence of a Default (as defined in Section 16.1 ), Landlord may draw all or any part of the Letter of Credit to pay delinquent payments due under this Lease, future rent damages, and the cost of any damage,
injury, expense or liability caused by such Default, without prejudice to any other remedy provided herein or provided by law. Landlord’s right to use the Letter of Credit under this Section includes the right to use the Letter of Credit to pay
future rent damages following the termination of this Lease pursuant to Section 16.2 below. Upon any use of all or any portion of the Letter of Credit, Tenant shall on demand deliver a new Letter of Credit or amend the existing
Letter of Credit to restore the Letter of Credit to the amount set forth on Page 1 of this Lease. Tenant hereby waives the provisions of any law, now or hereafter in force which provide that Landlord may claim from a security deposit only those sums
reasonably necessary to remedy defaults in the payment of Rent, to repair damage caused by Tenant or to clean the Premises, it being agreed that Landlord may, in addition, claim those sums reasonably necessary to compensate Landlord for any other
loss or damage, foreseeable or unforeseeable, caused by the Default of Tenant. Upon bankruptcy or other debtor-creditor proceedings against Tenant, the Letter of Credit shall be deemed to be applied first to the payment of Rent and other charges due
Landlord for periods prior to the filing of such proceedings. The Letter of Credit, or any balance thereof (i.e., after deducting therefrom all amounts to which Landlord is entitled under the provisions of this Lease), shall be returned to Tenant
(or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within 90 days after the expiration or earlier termination of this Lease. 

  
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 Provided that no Default (as defined in Section 16.1) has occurred or event that with the
passage of time, or the giving of notice, or both, would constitute a Default has occurred that remains uncured, the amount of the Security Deposit shall be reduced to the following amounts: (i) $1,044,247.90 effective as of the Rent
Commencement Date; (ii) $835,398.32 effective as of the first anniversary of the Rent Commencement Date; and (iii) $626,548.74 effective as of the second anniversary of the Rent Commencement Date. Within thirty (30) days following
receipt of Tenant’s written request for the applicable reduction, any portion of the Security Deposit in excess of the respective reduced amounts shall, if held by Landlord in cash, be refunded to Tenant, without interest, or Landlord shall
agree to an appropriate replacement or amendment of the Letter of Credit in order to effect the applicable reduction. 
 If Landlord
transfers its interest in the Project or this Lease, Landlord shall either (a) transfer any Security Deposit then held by Landlord to a person or entity assuming Landlord’s obligations under this Section, or (b) return to Tenant any
Security Deposit then held by Landlord and remaining after the deductions permitted herein. Upon such transfer to such transferee or the return of the Security Deposit to Tenant, Landlord shall have no further obligation with respect to the Security
Deposit, and Tenant’s right to the return of the Security Deposit shall apply solely against Landlord’s transferee. The Security Deposit is not an advance rental deposit or a measure of Landlord’s damages in case of Tenant’s
default. Landlord’s obligation respecting the Security Deposit is that of a debtor, not a trustee, and no interest shall accrue thereon. 

ARTICLE 28 
 RIGHT TO
EXTEND TERM 
 28.1 Extension Rights. Tenant shall have one right (an “Extension Right”) to
extend the term of this Lease for five (5) years (an “Extension Term”) on the same terms and conditions as this Lease (other than with respect to Base Rent and the Landlord’s Work) by giving Landlord written
notice of its election to exercise the Extension Right no sooner than fifteen (15) months earlier than and at least 12 months prior to the expiration of the Base Term of the Lease. 

Upon the commencement of the Extension Term, Base Rent shall be equal to the Market Rate (as defined below). Base Rent shall thereafter be
adjusted on each annual anniversary of the commencement of the Extension Term by multiplying the Base Rent payable immediately before such adjustment by the Rent Adjustment Percentage and adding the resulting amount to the Base Rent payable
immediately before such adjustment. As used herein, “Market Rate” shall mean the then market rental rate for space that includes laboratory and office space in the Cambridge, Massachusetts area of comparable age, quality,
level of finish and proximity to amenities and public transportation as the Premises, as determined by Landlord and agreed to by Tenant. In addition, Landlord may impose a market rent for the parking rights provided hereunder. 

If, on or before the date which is 180 days prior to the expiration of the Base Term of this Lease, Tenant has not agreed with Landlord’s
determination of the Market Rate during the Extension Term after negotiating in good faith, Tenant shall be deemed to have elected arbitration as described in this Article. Tenant acknowledges and agrees that, if Tenant has elected to exercise the
Extension Right by delivering notice to Landlord as required in this Article, Tenant shall have no right thereafter to rescind or elect not to extend the term of the Lease for the Extension Term. 

  
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 28.2 Arbitration. Within ten (10) days after Tenant’s notice to Landlord
of its election (or deemed election) to arbitrate Market Rate, each party shall deliver to the other a proposal containing the Market Rate that the submitting party believes to be correct (“Extension Proposal”). If either
party fails to timely submit an Extension Proposal, the other party’s submitted proposal shall determine the Base Rent for the Extension Term. If both parties submit Extension Proposals, then Landlord and Tenant shall meet within seven
(7) days after delivery of the last Extension Proposal and make a good faith attempt to mutually appoint a single Arbitrator (and defined below) to determine the Market Rate. If Landlord and Tenant are unable to agree upon a single Arbitrator,
then each shall, by written notice delivered to the other within ten (10) days after the meeting, select an Arbitrator. If either party fails to timely give notice of its selection for an Arbitrator, the other party’s submitted proposal
shall determine the Base Rent for the Extension Term. The two Arbitrators so appointed shall, within five (5) Business Days after their appointment, appoint a third Arbitrator. If the two Arbitrators so selected cannot agree on the selection of
the third Arbitrator within the time above specified, then either party, on behalf of both parties, may request such appointment of such third Arbitrator by application to any state court of general jurisdiction in the jurisdiction in which the
Premises are located, upon ten (10) days prior written notice to the other party of such intent. 
 (a) The decision of the
Arbitrator(s) shall be made within thirty (30) days after the appointment of a single Arbitrator or the third Arbitrator, as applicable. The decision of the single Arbitrator shall be final and binding upon the parties. The average of the two
closest Arbitrators in a three Arbitrator panel shall be final and binding upon the parties. Each party shall pay the fees and expenses of the Arbitrator appointed by or on behalf of such party and the fees and expenses of the third Arbitrator shall
be borne equally by both parties. If the Market Rate is not determined by the first day of the Extension Term, then Tenant shall pay Landlord Base Rent in an amount equal to the Base Rent in effect immediately prior to the Extension Term until such
determination is made. After the determination of the Market Rate, the parties shall make any necessary adjustments to such payments made by Tenant. Landlord and Tenant shall then execute an amendment recognizing the Market Rate for the Extension
Term. 
 (b) An “Arbitrator” shall be any person appointed by or on behalf of either party or appointed
pursuant to the provisions hereof and: (i) shall be (A) a member of the American Institute of Real Estate Appraisers with not less than ten (10) years of experience in the appraisal of improved office and high tech and life sciences
laboratory real estate in the greater Boston, Massachusetts metropolitan area, or (B) a licensed commercial real estate broker with not less than ten (10) years experience representing landlords and/or tenants in the leasing of high tech
or life sciences space in Cambridge, Massachusetts, (ii) devoting substantially all of their time to professional appraisal or brokerage work, as applicable, at the time of appointment and (iii) be in all respects impartial and
disinterested. 
 28.3 Rights Personal. The Extension Right is personal to Tenant and is not assignable without
Landlord’s consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s interest in the Lease. 

  
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 28.4 Exceptions. Notwithstanding anything set forth above to the contrary, at
Landlord’s option, the Extension Right shall not be in effect and Tenant may not exercise the Extension Right: 

(i) during any period of time that Tenant is in Default under any provision of this Lease; or 

(ii) if Tenant has been in Default under any provision of this Lease three or more times, whether or not the Defaults
are cured, during the 12 month period immediately prior to the date that Tenant intends to exercise the Extension Right, whether or not the Defaults are cured. 

28.5 No Extensions. The period of time within which the Extension Right may be exercised shall not be extended or enlarged by
reason of Tenant’s inability to exercise the Extension Right. 
 28.6 Termination. The Extension Right shall, at
Landlord’s option, terminate and be of no further force or effect even after Tenant’s due and timely exercise of the Extension Right, if, after such exercise, but prior to the commencement date of the Extension Term, (i) Tenant fails
to timely cure any Default by Tenant under this Lease; or (ii) Tenant has Defaulted three or more times during the period from the date of the exercise of the Extension Right to the date of the commencement of the Extension Term, whether or not
such Defaults are cured. 
 ARTICLE 29 

RIGHT OF FIRST OFFER 

29.1 Tenant’s Right of First Offer. After the initial lease-up of the entire Building, Tenant shall have a one-time Right
of First Offer to lease any space (“Offer Space”) in the Building subject to the right of Foundation Medicine after initial lease-up of the Building (and to the extent any space remains vacant after September 1, 2015)
and subject to the right of Landlord to extend or renew any then current lease (or enter into a new lease with the same tenant even if no extension or renewal rights are contained in the current lease) and subject to the following terms and
conditions: 
 (a) Landlord shall give notice (“Offer Notice”) to Tenant of the availability (or
anticipated availability) of such space, setting forth the terms and conditions on which Landlord would lease such space to Tenant which terms shall include rent at the Market Rate. The term of the lease for the Offer Space shall be co-terminus with
the Term for the Premises provided that there is at least five (5) years of unexpired Term remaining in the Base Term or Extension Term. Otherwise the term pertaining to the Offer Space shall be five (5) years unless a longer term is
requested by Tenant. Tenant shall have the right, exercisable by notice to Landlord given on or before the tenth (10th ) Business Day after receipt of the Offer Notice to lease such space on
the terms and conditions set forth in the Offer Notice. If Tenant shall not elect to lease such space within the ten (10) Business Day period, Landlord shall be free to lease such space at any time and on any terms and conditions; provided
however , that if Landlord intends to lease the Offer Space at an amount equal to or less than 95% of the rent offered to Tenant in the Offer Notice or 

  
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Landlord fails to lease the Offer Space within the twelve (12) month period following Tenant’s failure to elect or election not to lease such Offer Space, Landlord shall again offer the
Offer Space to Tenant pursuant to this Article 29 at such lower rent amount. The twelve (12) month deadline shall be extended as necessary if Landlord has commenced negotiations with a prospective tenant but not yet in good faith executed a
lease during the twelve (12) month period. 
 (b) The terms and provisions of Sections 28.3-28.6 shall be incorporated
into this Section and pertain to Tenant’s option to exercise its Right of First Offer as if originally stated herein. 
 ARTICLE 30

 MISCELLANEOUS 

30.1 Notices. All notices or other communications between the parties shall be in writing and shall be deemed duly given upon
delivery or refusal to accept delivery by the addressee thereof if delivered in person, or upon actual receipt if delivered by reputable overnight guaranty courier, addressed and sent to the parties at their addresses set forth above. Landlord and
Tenant may from time to time by written notice to the other designate another address for receipt of future notices. 
 30.2 Joint and
Several Liability. If and when included within the term “Tenant,” as used in this instrument, there is more than one person or entity, each shall be jointly and severally liable for the obligations of Tenant. 

30.3 Financial Information. Upon request from Landlord given not more than once in any twelve month period unless a Default
shall have occurred and remain outstanding, Tenant shall furnish Landlord with true and complete copies of Tenant’s most recent annual financial statements and Tenant’s most recent unaudited quarterly financial statements, in form
customarily prepared by Tenant. If Tenant becomes a “public company” and its financial information is publicly available, then the foregoing delivery requirements of this Section shall not apply. Such financial information shall be
provided subject to the requirement that Landlord agree to: (a) hold in confidence all such financial information and not disclose the financial information to third parties other than Landlord’s affiliates, attorneys, lenders and
consultants without the prior written consent of Tenant; (b) use the financial information solely in connection with this Lease; (c) treat the financial information with the same degree of care it uses to protect its own but in no event
with less than a reasonable degree of care; (d) reproduce the financial information solely to the extent necessary in connection with this Lease, with all such reproductions being considered confidential; and (e) disclose solely to its
employees or consultants on a need-to-know basis; provided, however , that (i) any such employees and consultants are bound by written obligations of confidentiality at least as restrictive as those set forth in this Lease, and
(ii) Landlord remains liable for the compliance of such employees and consultants with such obligations. 
 Landlord will not have
obligations of non-disclosure and non-use with respect to any portion of the financial information that Landlord can demonstrate, by clear and convincing evidence: (a) is generally known to the public at the time of disclosure or becomes
generally known through no wrongful act on the part of Landlord; (b) is in Landlord’s possession at the time of disclosure other than as a result of Landlord’s breach of any legal obligation; (c) becomes known to Landlord through
disclosure by sources other than Tenant having the legal right to disclose such financial information; or (d) is independently developed by Landlord without reference to or reliance upon the financial information as evidenced by written
records. 

  
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 If Landlord is required by a governmental authority or by order of a court of competent
jurisdiction to disclose any of the financial information, Landlord will give Tenant prompt written notice thereof and Landlord shall take all reasonable and lawful actions to avoid or minimize the degree of such disclosure. Landlord will reasonably
cooperate with Tenant in any efforts to seek a protective order. 
 30.4 Recordation. Tenant agrees not to record this
Lease, but upon request of either party, both parties shall execute and deliver a notice of this Lease in form appropriate for recording or registration, and if this Lease is terminated before the Term expires, an instrument in such form
acknowledging the date of termination. 
 30.5 Interpretation. The normal rule of construction to the effect that any
ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of this Lease or any exhibits or amendments hereto. Words of any gender used in this Lease shall be held and construed to include any other gender,
and words in the singular number shall be held to include the plural, unless the context otherwise requires. The captions inserted in this Lease are for convenience only and in no way define, limit or otherwise describe the scope or intent of this
Lease, or any provision hereof, or in any way affect the interpretation of this Lease. 
 30.6 Not Binding Until
Executed. The submission by Landlord to Tenant of this Lease shall have no binding force or effect, shall not constitute an option for the leasing of the Premises, nor confer any right or impose any obligations upon either party until
execution of this Lease by both parties. 
 30.7 Limitations on Interest. It is expressly the intent of Landlord
and Tenant at all times to comply with applicable law governing the maximum rate or amount of any interest payable on or in connection with this Lease. If applicable law is ever judicially interpreted so as to render usurious any interest called for
under this Lease, or contracted for, charged, taken, reserved, or received with respect to this Lease, then it is Landlord’s and Tenant’s express intent that all excess amounts theretofore collected by Landlord be credited on the
applicable obligation (or, if the obligation has been or would thereby be paid in full, refunded to Tenant), and the provisions of this Lease immediately shall be deemed reformed and the amounts thereafter collectible hereunder reduced, without the
necessity of the execution of any new document, so as to comply with the applicable law, but so as to permit the recovery of the fullest amount otherwise called for hereunder. 

30.8 Choice of Law. Construction and interpretation of this Lease shall be governed by the internal laws of the state in which
the Premises are located, excluding any principles of conflicts of laws. 
 30.9 Time. Time is of the essence as to the
performance of Tenant’s obligations under this Lease. 

  
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 30.10 OFAC. Tenant, and all beneficial owners of Tenant, are currently (a) in
compliance with and shall at all times during the Term of this Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive
order, or regulation relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of this Lease be listed on, the Specially Designated Nationals and Blocked Persons List maintained
by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or entity with whom a U.S. person is prohibited from
conducting business under the OFAC Rules. 
 30.11 Incorporation by Reference. All exhibits and addenda attached hereto are
hereby incorporated into this Lease and made a part hereof. If there is any conflict between such exhibits or addenda and the terms of this Lease, such exhibits or addenda shall control. 

30.12 Entire Agreement. This Lease, including the exhibits attached hereto, constitutes the entire agreement between Landlord
and Tenant pertaining to the subject matter hereof and supersedes all prior and contemporaneous agreements, understandings, letters of intent, negotiations and discussions, whether oral or written, of the parties, and there are no warranties,
representations or other agreements, express or implied, made to either party by the other party in connection with the subject matter hereof except as specifically set forth herein. 

30.13 No Accord and Satisfaction. No payment by Tenant or receipt by Landlord of a lesser amount than the monthly installment of
Base Rent or any Additional Rent will be other than on account of the earliest stipulated Base Rent and Additional Rent, nor will any endorsement or statement on any check or letter accompanying a check for payment of any Base Rent or Additional
Rent be an accord and satisfaction. Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such Rent or to pursue any other remedy provided in this Lease. 

30.14 Hazardous Activities. Notwithstanding any other provision of this Lease, Landlord, for itself and its employees, agents
and contractors, reserves the right to refuse to perform any repairs or services in any portion of the Premises which, pursuant to Tenant’s routine safety guidelines, practices or custom or prudent industry practices, require any form of
protective clothing or equipment other than safety glasses. In any such case, Tenant shall contract with parties who are acceptable to Landlord, in Landlord’s reasonable discretion, for all such repairs and services, and Landlord shall, to the
extent required, equitably adjust Tenant’s Share of Operating Expenses in respect of such repairs or services to reflect that Landlord is not providing such repairs or services to Tenant. 

30.15 REIT/UBTI. The Landlord and the Tenant hereby agree that it is their intent that all minimum rent and all other additional
rent and any other rent and charges payable to the Landlord under this lease (hereinafter individually and collectively referred to in this Section as “Rent”) shall qualify as “rents from real property” within the
meaning of Sections 512(b)(3) and 856(d) of the Internal Revenue Code of 1986, as amended, (the “Code”) and the U.S. Department of the Treasury Regulations promulgated thereunder (the “Regulations”).
In the event that (i) the Code or the Regulations, or interpretations thereof by the Internal Revenue Service contained in revenue rulings or other similar public pronouncements, shall be changed so that any Rent no longer so 

  
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qualifies as “rent from real property” for purposes of either said Section 512(b)(3) or Section 856(d) or (ii) the Landlord, in its sole discretion, determines that there
is any risk that all or part of any Rent shall not qualify as “rents from real property” for the purposes of either said Sections 512(b)(3) or 856(d), such Rent shall be adjusted in such manner as the Landlord may require so that it will
so qualify; provided, however, that any adjustments required pursuant to this Section shall be made so as to produce the equivalent (in economic terms) Rent as payable prior to such adjustment and shall not materially adversely affect the operations
of Tenant in the Premises. The parties agree to execute such further commercially reasonable instrument as may reasonably be required by the Landlord in order to give effect to the foregoing provisions of this Section. 

30.16 Quiet Enjoyment. So long as Tenant is not in Default under this Lease, Tenant shall, subject to the terms of this Lease,
at all times during the Term, have peaceful and quiet enjoyment of the Premises against any person claiming by, through or under Landlord. 

30.17 Prorations. All prorations required or permitted to be made hereunder shall be made on the basis of a 360 day year and 30
day months. 
 30.18 Rules and Regulations. Tenant shall, at all times during the Term and any extension thereof, comply with
all reasonable rules and regulations at any time or from time to time established by Landlord covering use of the Premises and the Project. The current rules and regulations are attached hereto as Exhibit J. If there is any conflict
between said rules and regulations and other provisions of this Lease, the terms and provisions of this Lease shall control. Furthermore, during the performance of Tenant’s Work, if there is any conflict between said rules and regulations and
the Tenant Design and Construction Guidelines attached hereto as Exhibit H, the terms and provisions of the Tenant Design and Construction Guidelines shall control. Landlord shall not have any liability or obligation for the breach of
any rules or regulations by other tenants in the Project and shall not enforce such rules and regulations in a discriminatory manner. 

30.19 Security. Landlord and Tenant acknowledge and agree that security devices and services, if any, while intended to deter
crime may not in given instances prevent theft or other criminal acts and that Landlord is not providing any security services with respect to the Premises and that Tenant is not providing any security services with respect to areas outside of the
Premises. Tenant agrees that, except to the extent caused by the negligence or willful misconduct of Landlord or any Landlord Party, Landlord shall not be liable to Tenant for, and Tenant waives any claim against Landlord with respect to, any loss
by theft or any other damage suffered or incurred by Tenant in connection with any unauthorized entry into the Premises or any other breach of security with respect to the Premises. Tenant shall be entitled to install and maintain security devices
and services as it deems appropriate within the Premises, and Landlord acknowledges that the scope of such security devices and services may include surveillance and monitoring of areas outside of the Premises provide that such devices do not affect
the rights and use and enjoyment of other tenants in the Building. Tenant shall be solely responsible for the personal safety of Tenant’s officers, employees, agents, contractors, guests and invitees while any such person is in, on or about the
Premises and/or the Project. Tenant shall at Tenant’s cost obtain insurance coverage to the extent Tenant desires protection against such criminal acts. 

  
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 30.20 Force Majeure. Neither party shall be responsible or liable for delays in the
performance of its obligations hereunder (other than monetary obligations) when caused by, related to, or arising out of acts of God, sinkholes or subsidence, strikes, lockouts, or other labor disputes, embargoes, quarantines, weather, national,
regional, or local disasters, calamities, or catastrophes, inability to obtain labor or materials (or reasonable substitutes therefor) at reasonable costs or failure of, or inability to obtain, utilities necessary for performance, governmental
restrictions, orders, limitations, regulations, or controls, national emergencies, delay in issuance or revocation of permits, enemy or hostile governmental action, terrorism, insurrection, riots, civil disturbance or commotion, fire or other
casualty, and other causes or events beyond the reasonable control of such party (“Force Majeure”). 
 30.21
Brokers. Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent or other person in connection with this transaction and that no broker brought about this transaction, other than the Brokers listed in
Section 1.1 hereof. Landlord and Tenant each hereby agree to indemnify and hold the other harmless from and against any claims by any broker, other than the Brokers named in Section 1.1, claiming a commission or other form of compensation
by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this leasing transaction. Landlord will be responsible to pay the commissions due to the named Brokers pursuant to a separate agreement. 

30.22 Severability. If any clause or provision of this Lease is illegal, invalid or unenforceable under present or future laws,
then and in that event, it is the intention of the parties hereto that the remainder of this Lease shall not be affected thereby. It is also the intention of the parties to this Lease that in lieu of each clause or provision of this Lease that is
illegal, invalid or unenforceable, there be added, as a part of this Lease, a clause or provision as similar in effect to such illegal, invalid or unenforceable clause or provision as shall be legal, valid and enforceable. 

[Signatures on next page] 

  
 57 








 IN WITNESS WHEREOF, Landlord and Tenant have executed this Lease as of the day and year
first above written. 
  

			
	 TENANT:
  

BLUEBIRD BIO, INC.,
 a Delaware corporation

		
	By:	 	 /s/ Nick Leschly

	Name:	 	 Nick Leschly

	Title:	 	 Chief Executive Officer

	
	 LANDLORD:
  

150 SECOND STREET, LLC,
 a Delaware limited liability
company

		
	By:	 	 /s/ Shawn Hurley

		 	Shawn Hurley, Manager
		
	By:	 	 /s/ Mats Johansson

		 	Mats Johansson, Manager



  
 58 








 EXHIBIT A TO LEASE 

PLAN OF PREMISES, STORAGE SPACES AND SHARED SPACES 

(Attached) 
  

  
 A-1 








 



 







 



 







 



 







 



 







 



 







 EXHIBIT B TO LEASE 

DESCRIPTION OF PROJECT 
 That
certain parcel of land with the buildings thereon situated in Cambridge, Middlesex County, Massachusetts being bounded and described as follows: 
 65
Bent Street, Cambridge, Massachusetts 
  

			
	WESTERLY	  	on Second Street, two hundred (200) feet;
	NORTHERLY	  	on Charles Street, three hundred (300) feet;
	EASTERLY	  	on land of owners unknown, two hundred (200) feet;
	SOUTHERLY	  	on Bent Street, three hundred (300) feet.

 Containing 60,000 square feet of land, any or all of said measurements being more or less. 

Subject to that certain Ground Lease dated November 12, 2010 by and between Bent Associates Limited Partnership, a Massachusetts limited partnership, as
ground lessor, and 150 Second Street, LLC, a Delaware limited liability company, as ground lessee, notice of which Ground Lease is recorded with the Middlesex County South District Registry of Deeds in Book 55812, Page 1. 

Being the same premises conveyed by Quitclaim Deed dated December 26, 1985 and recorded with said Deeds in Book 16676, Page 105. 

  
 B-1 








 EXHIBIT C TO LEASE 

ACKNOWLEDGMENT OF LEASE COMMENCEMENT DATE 

This ACKNOWLEDGMENT OF LEASE COMMENCEMENT DATE is made this      day of
        ,         , between 150 SECOND STREET, LLC, a Delaware limited liability company (“Landlord”), and
                    , a
                     corporation (“Tenant”), and is attached to and made a part of the Lease dated
            ,          (the “ Lease”), by and between Landlord and Tenant. Any initially capitalized terms used but
not defined herein shall have the meanings given them in the Lease. 
 Landlord and Tenant hereby acknowledge and agree, for all purposes of
the Lease, that the Lease Commencement Date of the Base Term of the Lease is                     ,
                     and the termination date of the Base Term of the Lease shall be midnight on
                    ,
                    . The Rent Commencement Date is             ,
        . In case of a conflict between the terms of the Lease and the terms of this Acknowledgment of Commencement Date, this Acknowledgment of Lease Commencement Date shall control for all purposes.

 IN WITNESS WHEREOF, Landlord and Tenant have executed this Acknowledgment of Lease Commencement Date to be effective on the date first
above written. 
  

			
	TENANT:
	
	
                          
                                         
                   ,
 a
                     corporation

		
	By:	 	  

	Its:	 	  

	
	LANDLORD:
	
	 150 SECOND STREET, LLC,
 a
Delaware limited liability company

		
	By:	 	  

	Name:	 	  

	Title:	 	  




  
 C-1 








 EXHIBIT D TO LEASE 

RENT CERTIFICATE 
 150 Second
Street, LLC 
 c/o Skanska USA Commercial Development Inc. 
 253
Summer Street 
 Boston, MA 02210 
  

	 	Re:	Lease dated as of                      by and between Rivertech Associates II, LLC (“
Landlord”), and Bluebird Bio, Inc. (“Tenant”), pertaining to the                      floor consisting of
                     rentable square feet of the building (collectively, the “ Premises”) located at 840 Memorial Drive,
Cambridge, Massachusetts (“Lease”). 

 The undersigned hereby certifies, represents and warrants to 150
Second Street, LLC and its successors, assigns, affiliates and lenders (together, the “New Landlord”), as follows and acknowledges that this certification, representation and warranty are being relied upon by the New Landlord in
connection with provisions of Section 4.2 of the Lease Agreement dated as of             , 2013 by and between New Landlord and Tenant pertaining to certain premises located at
150 Second Street, Cambridge, Massachusetts: 
 1. Tenant has previously delivered a true, accurate and complete copy of the Lease to the
New Landlord and there have been no amendments, modifications, side letters or other agreements relating to the Lease since such delivery. The Lease is in full force and effect. 

2. The term of the Lease expires on
                    . 
 3.
Tenant has paid to Landlord the monthly fixed rent of $         and monthly additional rent for operating costs and taxes of $         due under the Lease
through the period ended             , 20    . 

6. Tenant is not entitled to, and has made no agreement(s) with Landlord concerning, free rent, partial rent, rebate of rent payments, credit
or offset or deduction in rent, or any other type of rental concession, including, without limitation, lease support payments, lease buy-outs, or rental concessions pertaining to any unfunded tenant improvement allowance. 

7. Tenant has neither assigned its interest under the Lease, by operation of law or otherwise, nor entered into any sublease, concession
agreement or license pertaining to the Premises or any portion thereof. 
 8. Tenant has no option to reduce the Premises or no right to
terminate the Lease prior to the stated expiration date other than as specifically set forth in the Lease with respect to casualty and condemnation. The Landlord has no right to recapture any portion of the Premises prior to the stated expiration
date other than as specifically set forth in the Lease with respect to casualty and condemnation. 

  
 D-1 








 9. [If a Memorial Drive Rent Savings Event has occurred, in lieu of Sections 4, 5 or 6 above,
as the case may be, insert in substantially the following form: Tenant has entered into a sublease pertaining to the Premises. The monthly base rent and escalations due to Landlord is $         for
the period ended                     . The documented out of pocket transaction costs to Tenant in connection with the sublease is
$        . The rent payable under the sublease is $         for the period ended
                    . 
 Or in
the alternative, as the case may be: Tenant’s rent obligations under the Lease have terminated or been reduced by virtue of
                     (for example, lease termination agreement). The aggregate amount of rent savings under the Lease through the original
expiration date of the term of the Lease is $        . The documented out of pocket transaction costs to Tenant in connection with the (lease termination agreement) is
$        .] 
 Executed under seal as of the      day of
        , 20    . 
  

			
	 BLUEBIRD BIO, INC.,
 a
Delaware corporation

		
	By:	 	  

	Name:	 	  

	Title:	 	  




  
 D-2 








 EXHIBIT E TO LEASE 

BASE BUILDING SPECIFICATIONS 

  
 E-1 









 



 
  

 Base-Building Core & Shell Definition 

150 Second Street – Cambridge, MA 
 1.
GENERAL 
 Landlord is to deliver building for Use Group B and S-2, using Type I-B Construction in accordance with 780 CMR
Massachusetts State Building Code – 8th Edition. 
  

	 	A.	Basement Level – 12’-2” Floor-to-floor height. 

  

	 	B.	Ground Floor – 14’-8” Floor-to-floor height. 

  

	 	C.	Second Floor – 14’-8” Floor-to-floor height. 

  

	 	D.	Third Floor – 14’-8” Floor-to-floor height. 

  

	 	E.	Total area is approximately 123,210 RSF subject to final measurement. 

  

	 	F.	Structure designed to accommodate finish ceiling height of 9’-4” AFF. 

  

	 	G.	Slab to underside of beam dimension is 11’ typical with ability for utilities to be run though open webbed joists. 

  

	 	H.	General column spacing is 32’ x 45’. 

  

	 	I.	Building / Core and Shell Project designed to achieve LEED Gold Certification (NC). 

 2.
FOUNDATIONS AND SLAB-ON-GRADE 
  

	 	A.	Foundations consist of spread footings with a perimeter foundation wall. Basement slab consists of 5” reinforced concrete slab-on-grade. 


 

	 	B.	All foundation, slab-on-grade, and slabs-on-deck concrete will be controlled and tested in accordance with applicable building codes and standards. Concrete compressive strengths will be as required to meet structural
requirements, but no less than 4,000 psi. 

  

	 	C.	Concrete reinforcing steel conforms to ASTM 615. 

  

	 	D.	Welded wire mesh conforms to ASTM 185. 

  

	 	E.	Slab-on-grade designed for a 100 psf live load. 

 3. STRUCTURE 

 

	 	A.	The structure has been designed with the following live loads: 

  

	 	1.	Wind and seismic loads in accordance with State Building Code. 

  

	 	2.	Tenant area floors – 100 psf. 

  

	 	3.	Mechanical equipment rooms – 150 psf 

  

	 	4.	Penthouse Roof –20 psf Minimum Live Load and in accordance with governing building codes, plus allowances for specific snow drifting and equipment loads. 


 

	 	B.	The structure consists of an internally-braced steel frame supporting composite 3” metal deck with 4 1/2 “NW concrete fill at tenant floors, reinforced with 6 x 6 W.W.F. 


  
 



 
 E-2 









 



 
  


	 	C.	All steel is ASTM A36, A572 grade 50, A992 grade 50, A500 grade B, or as required. All shop and field-welded connections are welded in accordance with AWS standards. Bolted field connections have been made with
3/4” diameter A325 high-strength bolts, minimum. 

  

	 	D.	Floor deck at tenant floors consists of minimum 18 gauge steel or as engineered. All metal deck will conform to the Steel Deck Institute’s Code of Recommended Standard Practice. 


 

	 	E.	Composite steel floor deck concrete cover at floors have a minimum compressive strength of 4,000 psi and reinforced with welded wire mesh. 


 

	 	F.	Structure is fireproofed where required by the Commonwealth of Massachusetts Building Code. 

  

	 	G.	Fire exit stairs are standard steel pan stair assemblies with painted steel handrails and concrete treads. 

  

	 	H.	Miscellaneous iron items (elevator sill angles, ladders, railings, access platforms, stairs for accessing all equipment in compliance with OSHA and applicable codes, loose lintels, expansion plates, toilet partition
support frames, etc.) are provided as needed. 

 4. ROOFING AND WATERPROOFING 

 

	 	A.	Roofing system is a loose-laid, mechanically-fastened or fully adhered, single-ply membrane, TPO type similar to Carlisle. 

  

	 	B.	Roof insulation is extruded polystyrene board similar to Styrofoam by Dow, conforming to requirements of the Massachusetts State Energy Code and is acceptable for use with the roofing membrane specified.


  

	 	C.	Roof accessories such as bonding adhesive, splicing cement, lap sealant, tape, water cut-off mastic, etc., are compatible with the roofing membrane specified. Typical roof penetrations are flashed with material matching
the roof system. 

  

	 	D.	Metal flashing has been provided and a perimeter coping/gravel stop is anodized extruded or painted brake-formed aluminum. 

  

	 	E.	Elevator pits are waterproofed as required. 

  

	 	F.	Compatible roof walkway pads by the roofing manufacturer have been provided for base building equipment access and servicing. 

  

	 	G.	Base building includes a prescribed method for exterior window. Equipment to be provided by property management personnel. 


5. EXTERIOR WALLS 
  

	 	A.	The Building is clad with a combination of cementitious fiberboard, strip windows, curtain wall and composite metal panels. All glass is new energy efficient “low E” glass. 


  
 



 
 E-3 









 



 
  


	 	B.	Entrance doors are aluminum storefront doors. BOH doors are painted hollow metal. 

  

	 	C.	Loading dock exterior doors are electronically operated, high-cycle aluminum doors by Rytec or similar. 

 6.
INTERIOR FINISHES 
  

	 	A.	Main entrance floor finish is terrazzo flooring. Lobby walls are finished with a combination of wood paneling/glass/resin synthetic panel feature wall and painted drywall and ceilings. 


 

	 	B.	Core Toilet floors are ceramic tile or similar. Marble thresholds are provided at door openings where ceramic tile abuts other floor finishes. All toilet room wet walls are covered with ceramic tile or similar up to
ceiling. Paint is provided for the remaining walls. Toilet ceilings are acoustical tegular tile suspended ceilings with an exposed suspension grid, or drywall. Lavatory counters are polished granite or similar with under mounted sinks. All toilet
spaces throughout the building are of the same color and level of finish. Automatic flushometers and touchless faucets have been installed on all lavoratories, water closets, and urinals. 


 

	 	C.	Door frames are hollow metal (cold-formed steel). Solid core, wood veneer doors are provided for common area amenities such as toilet rooms. Painted hollow metal doors are provided for Base Building service areas. All
doors and hardware comply with regulations of the Massachusetts Architectural Access Board and The Americans with Disabilities Act. 

  

	 	D.	Landlord has provided the Base Building mechanical rooms, electrical rooms, telephone/data riser closets and janitorial closets in core area on typical floors and ground floor. 


 

	 	E.	Inside face of typical exterior walls consists of the back of the façade cladding system with insulation, fireproofed as required by code. 


 

	 	F.	Lobby and Base Building interior lighting consists of architecturally specified efficient lighting. 

  

	 	G.	Typical stair finishes include concrete floors and treads, painted steel risers and rails, primed and painted drywall surfaces. 


7. SPECIALTIES & EQUIPMENT 
  

	 	A.	Building Directory’s will be provided by Base Building. Base Building will specify and install signage required by code, including City of Cambridge Inspectional Services and Fire Dept. for Base Building portion of
construction. 

  

	 	B.	Metal toilet partitions are steel panels with brushed stainless steel finish, and floor-mounted. 


  
 



 
 E-4 









 



 
  


	 	C.	Toilet room accessories, brushed stainless steel, Bobrick Co., or equal: recessed paper towel dispenser; toilet paper holders; soap dispensers; grab bars. 


8. VERTICAL TRANSPORTATION 
  

	 	A.	Two (2) gearless, standard elevators based on the following quantities, speeds and capacity: One (1) 3,500 #, 200fpm passenger elevator serving Basement through 3 rd floors and One (1) 4,000, 200fpm,
double-sided combination service / passenger elevator serving Basement through penthouse floors. Interior cab finishes are similar in quality and context to ground floor lobby. 


9. PLUMBING 
  

	 	A.	Domestic water system supplied by dual metered service from public water mains. Piping is type “L” copper. Two (2) 125 gallon, gas-fired domestic water heaters are provide re-circulating hot water
to accommodate core toilet rooms and tempered water risers. 

  

	 	B.	Stormwater is reclaimed from a portion of the roof; collected in an underground storage tank and reused for toilet and urinal flushing to supplement potable water requirement. Overflow from tank and the remainder of the
roof discharges to a storm infiltration system. 

  

	 	C.	Low pressure gas service provided to all base building equipment. Gas riser is sized with additional capacity to supply tenant provided generators. 


 

	 	D.	Typical toilet rooms on floors 1-3 have fixture count as required by code. All water closets and urinals are wall hung to facilitate floor cleaning. All fixtures are “low-flow” type, hands-free.
Lavatory sinks are under mounted and have metered and motion sensor operated faucet controls with hot water flow restrictors. 

  

	 	E.	Showers are provided on the first floor. 

  

	 	F.	Non-potable cold water risers are provided to supply non-potable connection at each floor. 

  

	 	G.	Clear water waste receivers aree provided at each floor to accept RO reject water, condensate and similar clean water. This water can also be collected in the above-mentioned tank for reuse. 


10. FIRE PROTECTION SYSTEM 
  

	 	A.	Fire protection is fed from a 6” service from the public water main. An in-line, vertical fire pump feeds two (2) 6” combined standpipes, to provide pressure for the sprinkler system. 


 

	 	B.	Hose connections for Fire Department use will be provided as required by code for base building only. Piping will be black steel pipe schedule 10 for pipe 2 1/2” and larger and schedule 40 for pipe 2” and
smaller. All piping, valves and equipment is UL-Listed and labeled. Tamper switches are provided on all control valves. 


  
 



 
 E-5 









 



 
  


	 	C.	Automatic sprinkler system is supplied from the combination sprinkler/standpipe risers in each stair. The sprinkler systems on each floor is connected to the riser in each stair. All occupied space in the building is
fully sprinklered using upright sprinkler heads, at a density in accordance with code. Sprinkler coverage is designed for light hazard protection in core and common areas, ordinary hazard group 1 protection in mechanical and storage areas, and up to
ordinary hazard group 2 in tenant lab areas. 

 11. HEATING, VENTILATING AND AIR CONDITIONING 

 

	 	A.	The cooling system includes a chilled water plan consisting of three (3) 300-ton water-cooled centrifugal chillers, associated pumps, and distribution to two (2) custom manufactured variable volume air
handling units with a nominal capacity of 82,000CFM. Heat is rejected to the atmosphere by two (2) 625-ton cooling towers equipped with whisper quiet fans. 

  

	 	B.	Heating is provided by hot water risers fed from four (4) 2,700-MBH gas-fired, condensing boilers. Valved branch lines on the hot water risers is provided to each floor for tenant use. 


 

	 	C.	Laboratory exhaust is provided by two (2) 82,000 CFM variable volume exhaust air handlers with energy recovery systems to transfer heat from the exhaust to the outside air entering the building. 


 

	 	D.	Space is provided for additional tenant dedicated air handlers, exhaust air handlers, cooling towers, boilers and chillers. 

  

	 	E.	Tenant supplemental cooling capacity is provided by secondary condenser water risers connected to the building’s cooling towers by 140 ton plate and frame heat exchanger providing approximately 45 tons of cooling
to each floor. 

  

	 	F.	Garage exhaust is equipped with a total capacity of 20,600CFM exhaust control with carbon monoxide sensors and VFD control. 

  

	 	G.	The Building Automation System is equipped with Direct Digital Control (DDC). The DDC system incorporates a complete graphics interface package to monitor and control all HVAC systems. The system is expandable to
include all tenant systems and equipment. 

  

	 	H.	One 660 gallon double wall fuel storage tank is provided to feed the life-safety emergency generator in the mechanical penthouse. 

  

	 	G.	Toilet areas have exhaust air systems maintaining an exhaust rate of 75CFM/fixture. 

  

	 	H.	Base building provides infrastructure for approximately 75 degrees Fahrenheit, dry bulb at 55% relative humidity during the cooling season and approximately 70 degrees Fahrenheit during the heating season; both based on
ASHRAE design conditions of the City of Boston. 

 OUTDOOR DESIGN CONDITIONS ( ASHRAE 1%) 

 

					
	A.	 	Summer:	    	91 F dry bulb
		 		    	88 degrees Farhrenheit dry bulb, 73 degree Farhrenheit wet bulb
	B.	 	Winter:	    	6 degrees Fahrenheit Dry Bulb


  
 



 
 E-6 









 



 
  

 INDOOR DESIGN CONDITIONS 

 

					
	A.	  	Summer:	    	74 F dry bulb 50 % RH
	B.	  	Winter:	    	72 F dry bulb 20% RH

 VENTILATION 

Minimum Outside Air: In accordance with the Massachusetts State Building Code, 8th Edition 

 

			
	Anticipated occupancy:	  	7 people per 1000sf for office
		  	50 people per 1000sf for conference room
	Ventilation Rate:	  	1.7 CFM/sq ft

 INTERNAL HEAT GAIN 
  

			
	Occupants:	  	108sf/person (useable sf)
	Lighting	  	1.0 watts/useable sf
	Power	  	7 watts/useable sf

  

	 	G.	Outside air for ventilation is provided by four ventilation riser ducts stubbed into 1 location on each floor in accordance with current codes and ASHRAE standards. Ventilation and exhaust airflows for Tenant needs
shall be designed by Tenant designers. Available floor exterior static pressure allowance shall be 0.75”wc. 

  

	 	I.	Base Building mechanical equipment is provided with necessary acoustical vibration isolation as recommended by an independent acoustical consultant to achieve a Sound Transmission Class in accordance with code.


 12. ELECTRICAL 
  

	 	A.	Base building service is a metered 3,000-amp 277/480V 3-phase, 4 wire electric service 

  

	 	B.	Each tenant floor is served by a separately unmetered 800-amp 277/480V 3-phase, 4 wire electric service capable of providing 12w/sf of tenant floor power 


 

	 	C.	Spare capacity is provided at the building switchgear for additional electric service as required. 

  

	 	D.	A 250 KW, diesel engine generator to accommodate base building life safety requirements is provided. 

  

	 	E.	One telephone/data closet per floor is provided in base building for tenant installed risers and distribution cabling, consisting of three (3) riser sleeves at 5” each 


 

	 	F.	A fully addressable code compliant fire alarm system is installed with sufficient power supplies and infrastructure capacity at the head end for the future tenant tie-in. The tenant is responsible for electronic release
devices and locking mechanisms at stair tower egress doors if the tenant intends to use stairwells for inter-floor travel. The tenant is to supply, install and coordinate all fire alarm notification and initiating devices within the tenant space
connected to base building systems. Base Building egress stairwell doors will be passage type, unlocked. 

  

	 	G.	Fire alarm system includes a City of Cambridge Master Box, all front end equipment, common area ADA notification and alarm initiating devices, elevator recall, and terminal boxes on each floor for connection of tenant
fire alarm and notification devices to the base building system. The fire alarm terminal cabinets shall be located in the electrical closets. 


  
 



 
 E-7 









 



 
  


	 	H.	Base building security system provides building perimeter security with card readers and CATV. Tenant security system is to be designed by the tenant for its specific needs. Tenant will be responsible for system design,
distribution wiring and installing all the cameras, access control, and related appurtenances as part of TI. 

 —END—


  
 



 
 E-8 








 EXHIBIT F TO LEASE 

LANDLORD TENANT MATRIX 

  
 F-1 








 Skanska Commercial Development Inc 

150 Second Street 
 5.15.13 

Allocation of Responsibility Between Landlord and Tenant Work 
  

							
	 ELEMENT
	  	 DESCRIPTION
	  	 BASE

BUILDING

WORK
	  	 TENANT

WORK

				
	 SITE IMPROVEMENTS:
	  	Entrance Plaza, perimeter sidewalks, street trees, street lights and furniture in accordance with the Approved Project.	  	X	  	
				
		  	Telephone conduit from outside building into basement floor telephone room.	  	X	  	
				
		  	Cable/Data conduit from outside building into basement telephone room	  	X	  	
				
		  	Electrical Service to building	  	X	  	
				
		  	Gas Service to building for base building and tenant systems	  	X	  	
				
		  	Domestic sanitary sewer connection to street	  	X	  	
				
		  	Lab waste sanitary sewer connection from tenant pH room in basement floor to building drain.	  	X	  	
				
		  	Domestic and fire protection water service to building.	  	X	  	


  
 F-2 









							
	 CODE COMPLIANCE:
	  	Building construction in accordance with requirements of Massachusetts State Building Code, 8th edition (as amended, restated, or superseded as applicable)	  	X	  	X
				
	 STRUCTURE:
	  	Floor systems capable of supporting a live / partition load of 100 lbs. psf on all floors	  	X	  	
				
		  	14’8” Floor to floor heights, 12’ floor to floor height in B1	  	X	  	
				
		  	Floor construction to accommodate 100lbs/sf on floors 1 through 3. Penthouse floor construction to accommodate 150lbs/sf	  	X	  	
				
		  	Structural modifications to increase floor live load capacity	  		  	X
				
		  	Structural modifications to accommodate tenant specific openings including but not limited to shafts, risers, and interconnecting stairs	  		  	X
				
		  	Framed openings for base building supply air and tenant exhaust shafts	  	X	  	
				
		  	All catwalks and dunnage required to support and enable access to Base Building mechanical equipment.	  	X
	  	
				
		  	All structural modifications, dunnage, catwalks and other requirements necessary to support and enable access to Tenant equipment in Penthouse	  		  	X


  
 F-3 









							
		  	Miscellaneous metal items such as brackets or supports and concrete housekeeping pads required for tenant supplied equipment	  		  	X
				
		  	Structural assemblies requiring fire-proofing to be sprayed with cementitious fireproofing system	  	X	  	X
				
	 BUILDING ENVELOPE:
	  	Environmentally responsible sustainable building design that achieves LEED Gold Certification.	  	X	  	
				
		  	Facade of aluminum and glass window wall, cementitious rain screen and metal panels, with thermally insulated glass including light-gauge metal stud back-up with insulation where required	  	X	  	
				
		  	Overhead coiling doors at loading dock and at parking garage entry	  	X	  	
				
		  	Acoustic roof screen to conceal tenant exhaust fans and standby generators	  	X	  	
				
		  	Architecturally integrated, enclosed mechanical penthouse with space for tenant mechanical equipment.	  	X	  	
				
		  	Any modifications to façade, penthouse or screen wall system necessary to accommodate tenant requirements, provided that any such modifications must be approved by Landlord.	  		  	X
				
	 ROOFING:
	  	TPO system with walking pads to all base building mechanical equipment.	  	X	  	


  
 F-4 









							
		  	Roofing penetrations for tenant equipment or systems, to be made in accordance with roofing manufacturer’s details and warranty requirements	  		  	X
				
		  	Walking pads to tenant special mechanical equipment.	  		  	X
				
	 COMMON AREAS:
	  	Entrance lobby with finishes that include stone, tile & carpet flooring, wood or stone wall accents, drywall and suspended ceilings and appropriate accent lighting.	  	X	  	
				
		  	Finished egress stairways and corridors as required for occupant circulation and emergency egress	  	X	  	
				
		  	Men’s and Women’s shower rooms located near first floor bathrooms	  	X	  	
				
		  	Exterior loading area with two truck bays with access and space for one rubbish dumpster	  	X	  	
				
		  	Loading Dock Lift (if required)	  		  	X
				
		  	Ground floor recycling room	  	X	  	
				
		  	Basement level parking area	  	X	  	
				
		  	Bike racks located in basement	  	X	  	
				
		  	Finished basement floor main electrical service rooms, water and fire pump room	  	X	  	
				
		  	Finished toilet rooms, janitor closets, telephone and electric closets, and egress stairways serving each floor.	  	X	  	


  
 F-5 









							
		  	Construction of code-required corridor system on each floor, including door packages, ready for Tenant finish if tenant occupies entire floor.	  		  	X
				
		  	Construction of and finish for common corridors and elevator lobbies on multi-tenant floors.	  	X	  	
				
		  	Rooftop mechanical penthouse and screened roof area for base building mechanical equipment. Rooftop expansion space allocated for tenant mechanical equipment in designated locations within the screen wall.	  	X	  	
				
		  	Doors and frames at common areas: hollow metal frames; hollow metal doors at service areas, solid core wood doors at other areas, and lever hardware	  	X	  	
				
		  	Doors, frames, and hardware to tenant areas	  		  	X
				
	 ELEVATORS
	  	One gearless passenger elevator with 3,500 lb. capacity	  	X	  	
				
		  	One gearless combination freight/passenger elevator with 4,000lb capacity	  	X	  	
				
		  	Dedicated shaft way for third elevator	  	X	  	
				
		  	Third Elevator if required	  		  	X
				
	 WINDOW TREATMENT:
	  	Supply and installation of building standard blinds for all windows	  		  	X
				
		  	Modifications to window wall system approved by Landlord	  		  	X


  
 F-6 









							
		  	Signage, lighting and other brand identity treatments approved by Landlord	  		  	X
				
	 TENANT AREAS:
	  	Construction of and finishes for corridors and elevator lobbies for single tenanted floors	  		  	X
				
		  	Light gauge framing, insulation & vapor barrier on inside face of exterior walls.	  	X	  	
				
		  	Interior wall furring and sills (if applicable) and drywall finish at perimeter walls.	  		  	X
				
		  	Interior drywall soffit at perimeter of building with blocking for building standard window treatments.	  		  	X
				
		  	Partitions, ceilings, flooring, painting, doors, millwork and all related finishes for office and laboratory build out within Tenant premises	  		  	X
				
	 HVAC:
	  	Processed condenser water system capable of providing 45 Tons per floor at 2.4 GMP per Ton per Floor	  	X	  	
				
		  	(2) Condenser Water Supply and Return Distribution Risers connected to a plate/frame heat exchanger with 2- 1/2” valves capped on floors 1 through 3 for tenant distribution and 1 1/2” valves capped in the basement on the
east side of the building.	  	X	  	
				
		  	Condenser Water on-floor distribution	  		  	X


  
 F-7 









							
		  	Central Chilled Water Plant sized to provide cooling with 100% outside air at 1.7CFM per usable sf	  	X	  	
				
		  	Allotted space for future 150ton chiller to accommodate expansion of system to 2CFM per usable sf	  		  	X
				
		  	Processed Chilled Water system capable of providing 45 Tons per floor with energy recovery taken into account	  	X	  	
				
		  	Plate and Frame heat exchanger, associated piping and pumps to connect chilled water riser to existing chillers and/or future 150ton chiller	  		  	X
				
		  	(2) Processed Chilled Water Supply and Return Distribution Risers	  	X	  	
				
		  	Processed Chilled Water Supply and Return riser connection in penthouse to tenant provided chiller (if required)	  		  	X
				
		  	Excess Capacity in base building chiller plant to provide chilled water to each floor (capacity subject to chilled water on floor use)	  	X	  	
				
		  	Tenant Chiller for Tenant Process Chilled Water	  		  	X
				
		  	Penthouse air handling units capable of providing 1.7 CFM per usable sf. Vertical supply ducts sized to accommodate 2.0CFM stubbed out in (2) locations per floor	  	X	  	
				
		  	Additional AHU to exceed 1.7CFM/sf of supply	  		  	X


  
 F-8 









							
		  	General laboratory exhaust fans capable of exhausting 1.7 CFM per usable sf. Vertical exhaust ducts sized to accommodate 2.0CFM stubbed out in (2) locations per floor	  	X	  	
				
		  	Additional laboratory exhaust fans to exceed 1.7CFM/sf of exhaust	  		  	X
				
		  	All on-floor supply and exhaust distribution in tenant spaces	  		  	X
				
		  	Central Heating Plant consisting of condensing boilers supplying hot water to AHU’s and other shell and core heating elements.	  	X	  	
				
		  	Allotted space for future condensing boiler	  	X	  	
				
		  	Future boiler and associated piping and pumps to accommodate expansion of system to 2CFM per usable sf	  		  	X
				
		  	(2) Hot water supply and return distribution risers with 2- 1 / 2” valves capped on floors 1 through 3 for tenant distribution. 1 1 / 2” riser drops to basement level on the East side of the building.	  	X	  	
				
		  	All hot water supply and return on-floor distribution for tenant use	  		  	X
				
		  	Any additional mechanical equipment and/or any modifications to Base Building equipment to increase the mechanical capacity of the building.	  		  	X


  
 F-9 









							
		  	Ductwork, VAV boxes, registers and controls for HVAC in lobby spaces and core areas, including toilet exhaust system.	  	X	  	
				
		  	Supply and exhaust air distribution within the tenant space including all medium pressure and low pressure ducts, diffusers, registers, grilles, terminal volume control boxes, VAV boxes, fan powered units, reheat coils, baseboard
radiation and hot water piping.	  		  	X
				
		  	Toilet and/or shower ventilation requirements for additional tenant locker rooms and restrooms as required.	  		  	X
				
		  	Central DDC computerized energy management system for applicable core and shell system with expansion capacity for tenant fit out systems.	  	X	  	
				
		  	Temperature controls within tenant space, and links to base building system.	  		  	X
				
		  	Dedicated kitchen exhaust system	  		  	X
				
		  	All components of tenant exhaust systems, including fume hoods, floor distribution ductwork, specialty high corrosive system ducts and dedicated exhaust fans, controls, equipment dunnage and sound attenuation.	  		  	X
				
		  	Dedicated air handler, additional cooling, additional heating and associated ductwork, equipment and controls if required for a Tenant Animal Care Facility.	  		  	X


  
 F-10 









							
		  	Specialized tenant systems and equipment including supplemental or spot cooling, steam boilers, dedicated rated exhaust for H2 or H3 storage rooms, air and vacuum systems and all related HVAC equipment.	  		  	X
				
		  	Additional sound attenuation necessary to ensure tenant’s equipment complies with local noise regulations.	  		  	X
				
		  	Carbon Monoxide Monitored garage exhaust system	  	X	  	
				
		  	Fuel oil storage tank, transfer pumps and distribution piping for Base Building life safety emergency generator	  	X	  	
				
		  	Fuel oil system tenant provided stand-by generator.	  		  	X
				
		  	BTU Meters connected to BAS for hot, condenser, and processed chilled water at floor connections	  		  	X
				
		  	Air monitoring flow stations connected to BAS for exhaust	  		  	X
				
		  	Air monitoring flow stations connected to BAS for supply (at Floor take-offs or at terminal units if required by tenant)	  		  	X
				
	 GAS:
	  	Gas service capable of providing low-pressure (10” w.g. ) service.	  	X	  	
				
		  	Gas piping for Base Building equipment.	  	X	  	


  
 F-11 









							
		  	6” Gas service brought to tenant non-roofed penthouse for tenant provided generator capable of providing 8000 cfh (tenant premises to dictate allocation)	  	X	  	
				
		  	Gas Sub-meter for tenant use	  		  	X
				
		  	Gas connection to tenant generator	  		  	X
				
		  	Any and all tenant required gas service and distribution for on-floor use	  		  	X
				
	 PLUMBING:
	  	Domestic water service, with back-flow prevention and duplex booster.	  	X	  	
				
		  	(2) Gas Fed Boilers providing hot water to restrooms and tempered water risers	  	X	  	
				
		  	Hot water supply and return risers and distribution to restrooms	  	X	  	
				
		  	Core and Restroom plumbing and fixtures to meet code requirements	  	X	  	
				
		  	(1) 4” Domestic Cold water riser with 1” connections valved and capped on floors 1 through 3	  	X	  	
				
		  	Water Sub-meter and on-floor distribution of domestic cold water	  		  	X
				
		  	Hot water plumbing including heaters, boilers, distribution and associated equipment for tenant use	  		  	X
				
		  	(2) 2” Tempered Water Risers valved and capped on floors 1 through 3 providing 70-90 degree water	  	X	  	
				
		  	Tempered Water Sub-meter and on-floor distribution for tenant use	  		  	X


  
 F-12 









							
		  	(2) 3” Nonpotable Water risers fed from 2 booster pumps stubbed out on floors 1 through 3	  	X	  	
				
		  	Nonpotable Water submeter and on-floor distribution	  		  	X
				
		  	Installation of Tenant’s non-potable/potable water heaters.	  		  	X
				
		  	Tenant metering, sub metering, distribution and backflow prevention at laboratory connections.	  		  	X
				
		  	Waste and vent risers for tenant non-lab waste	  	X	  	
				
		  	Connection to non-lab waste and vent	  		  	X
				
		  	Shaft Space for lab waste and vent risers	  	X	  	
				
		  	Lab waste and vent risers for tenant use	  		  	X
				
		  	Domestic sanitary sewer, storm, and water to/from city	  	X	  	
				
		  	Roof and canopy storm drains	  	X	  	
				
		  	Production and distribution of clean steam including fuel source.	  		  	X
				
		  	Steam generator, fuel source, floor by floor humidification associated steam piping and reducing stations.	  		  	X
				
		  	All non-base building plumbing including kitchen, cafeteria and specialized equipment.	  		  	X


  
 F-13 









							
		  	Reserved, allocated space in basement for tenant’s acid neutralization system	  	X	  	
				
		  	Acid waste neutralization equipment, lifting stations and laboratory waste lines including distribution, pumps, and risers.	  		  	X
				
		  	Manifolds, piping, floor drains, equipment and other requirements for laboratory gases, compressed air, vacuum systems and RO/DI water systems. Distributed vertical utility chases are provided.	  		  	X
				
		  	Waste stacks to receive base building and tenant clear water wastes (e.g., a.c. condensate, RO reject).	  	X	  	
				
	 ELECTRICAL:
	  	Base building electric metered by Nstar at main switchboard	  	X	  	
				
		  	Tenant electric metered by Nstar on tenant floor	  		  	X
				
		  	Tenant submeter for any specialized and/or processed loads (data center, etc.)	  		  	X
				
		  	Life safety lighting and other “Legally Required” emergency power systems.	  	X	  	
				
		  	Automatic transfer switch for emergency and egress lighting	  	X	  	X
				
		  	Building electrical service to provide two 3,000 Ampere 480/277 Volt, 3 phase, 4 wire via main switchboards in main electrical room.	  	X	  	


  
 F-14 









							
		  	Allocation of approximately 12 watts/sf for tenant distribution with 15 watts/sf for lab area and 5 watts/sf for office area based on 70%/30% lab to office ratio% office	  	X	  	
				
		  	(2) 4” Conduits from unmetered switchboard in basement to 800AMP unmetered wireway	  	X	  	
				
		  	Conductor from basement switchboard to 800 AMP wireway in each floor’s electric room	  		  	X
				
		  	CT cabinet, utility meter, high voltage, low voltage and distribution for tenant power	  		  	X
				
		  	All power for any and all systems within tenant space	  		  	X
				
		  	Lighting & receptacles serving core areas.	  	X	  	
				
		  	Building Exterior lighting package.	  	X	  	
				
		  	Exterior and Interior Tenant Signage lighting package	  		  	X
				
		  	Diesel fuel life safety generator to provide emergency power for MA code-required egress lighting, fire alarm systems, common area emergency egress lighting and exit signs, capacity to serve emergency egress and exit lighting in
tenant areas and lab exhaust fans.	  	X	  	
				
		  	Emergency Transfer switch(s) capable of providing power to code required emergency equipment.	  	X	  	


  
 F-15 









							
		  	Back-up generator and systems, including transfer switch, distribution, controls and associated appurtenances	  		  	X
				
		  	Emergency egress and exit lighting in core areas.	  	X	  	
				
		  	Emergency egress and exit lighting fixtures in tenant area, connected to Base Building life safety emergency generator.	  		  	X
				
	 FIRE PROTECTION:
	  	Sprinkler service entrance including fire department connection, alarm valve, backflow protection and standpipe in each stair.	  	X	  	
				
		  	Fire Pump and all related controls	  	X	  	
				
		  	Core and stair area sprinkler heads and piping.	  	X	  	
				
		  	Flow control valve station in stair at each floor.	  	X	  	
				
		  	Primary sprinkler distribution on each floor.	  	X	  	
				
		  	All run outs, drops, heads and related equipment within tenant premises.	  		  	X
				
		  	All run outs, drops, heads and related equipment within unleased and unoccupied space within the building as required to obtain a building occupancy permit.	  	X	  	
				
		  	Special extinguishing systems.	  		  	X
				
		  	Fire Extinguisher Cabinets in core area with appropriate Fire Extinguisher	  	X	  	


  
 F-16 









							
		  	Fire Extinguisher Cabinets in tenant area (building standard) with appropriate Fire Extinguisher	  		  	X
				
		  	Additional hose connection in fit-up spaces to meet 150 foot distance requirements of Cambridge Fire Department.	  		  	X
				
	 FIRE ALARM:
	  	Base building expandable addressable fire alarm system that meets all code requirements.	  	X	  	
				
		  	Detection and annunciation devices (i.e. horns and strobes) in core areas and stair entries.	  	X	  	
				
		  	Detection, annunciation and all wiring in tenant areas and as required to tie into base building system.	  		  	X
				
	 TELECOMMUNICATIONS
	  	Main Distribution Frame (MDF) telephone room, core riser closets on each floor with sleeves through slab.	  	X	  	
				
		  	(4) 4” Conduits from City Service Ductbank into main tel/data closet in basement	  	X	  	
				
		  	Primary POS and distribution into tenant space	  		  	X
				
		  	Telephone and data wiring, conduits and outlets for Tenant areas from core closets.	  		  	X
				
		  	Audio-visual connections and systems for Tenant areas.	  		  	X
				
		  	Any special equipment needed to provide specific requirements for tenants telephone equipment.	  		  	X


  
 F-17 









							
	 SECURITY:
	  	(Base) Building security network system for monitoring and access control.	  	X	  	
				
		  	Card access at Building main entries, service doors, and traveling cable for security in elevators.	  	X	  	
				
		  	Card access in elevator cabs if required	  		  	X
				
		  	Electric door hardware and wiring on interior emergency egress doors in Stair #1 only.	  	X	  	
				
		  	Electric door hardware and wiring on interior emergency egress does in Stair #2	  		  	X
				
		  	Card access and/or alarm systems into or within Tenant’s premises. Emergency egress doors must be tied into Base Building Fire Alarm system.	  		  	X
				
		  	CCTV DVR surveillance in basement and at ground floor entries	  	X	  	
				
	 SIGNAGE:
	  	Building and site exterior address, directional, and any common identity signage to owner standards.	  	X	  	
				
		  	Building common area interior signage.	  	X	  	
				
		  	Signage within tenant’s space.	  		  	X
				
		  	Exterior Signage subject to Landlord Approval	  		  	X


  
 F-18 








 EXHIBIT G TO LEASE 

TENANT’S CONCEPT PLAN 

  
 G-1 








 



 







 EXHIBIT H TO LEASE 

TENANT DESIGN AND CONSTRUCTION GUIDELINES 

  
 H-1 








 



 

  
 H-2 








 



 
  
  

Table of Contents 
  

					
	Section I: Rules & Procedures for Tenant Contractors	  	 	H-4	  
		
	Section II: Insurance Requirements for Tenant Contractors	  	 	H-12	  
		
	Section III: Close-Out Requirements for Tenant Contractors	  	 	H-16	  
		
	Section IV: Tenant Improvement Standards	  	 	H-18	  
		
	Section V: LEED Guidelines	  	 	H-22	  
		
	 Part A: Introduction and General Information
	  	 	H-23	  
		
	 Part B: LEED-CS and LEED-CI Certification
	  	 	H-25	  
		
	 1. Sustainable Sites (SS)
	  	 	H-25	  
	 2. Water Efficiency (WE)
	  	 	H-33	  
	 3. Energy and Atmosphere (EA)
	  	 	H-35	  
	 4. Materials and Resources (MR)
	  	 	H-38	  
	 5. Indoor Environmental Quality (IEQ)
	  	 	H-42	  
	 6. Innovation in Design (ID)
	  	 	H-49	  
	 Appendix A: Reference Material
	  	 	H-50	  

  
 



 

  
 H-3 








 



 
  
 



 

  
 H-4 









 



 
  
  

 

 Section I: Rules & Procedures for Tenant Contractors 

Introduction 
 The following requirements apply only to
Tenant’s contractors and have been developed to ensure that modifications or improvements to the building and/or building systems and equipment are completed to building standards while maintaining a level of safety consistent with industry
standards. The review of tenant plans and/or specifications by Landlord and its insurers, consultants or other representatives, does not imply that any plans so reviewed comply with applicable laws, ordinances, codes, standards or regulations. Nor
does Landlord’s review or approvals imply that any work is to be performed at Landlord’s expense. 
 Landlord has the explicit right to remove
from the project any person who does not comply with these rules after one day’s notice. 
 Part A: General 

 

	1.	No work will be performed until the Landlord has received two (2) sets of signed and sealed drawings and specifications and has given written approval. 


 

	2.	All modifications to the building or to the building systems and equipment must comply with state, federal and local codes and ordinances. 


 

	3.	Prior to the work commencing, a building permit must be obtained and displayed and a certificate of insurance from the contractor must be furnished to the Landlord naming the as additional insureds all parties specified
in the Lease. 

  

	4.	At the completion of the work, the Leasehold Contractor shall furnish to the Landlord two (2) hard copies of redlined “as builts” as installed by the Leasehold Contractor and one (1) complete
CADD.DWG disk file showing the final architectural and engineering drawings. 

  

	5.	The contractor must notify the Landlord of all work scheduled and must provide the Landlord with a list of all personnel working in the building. 


 

	6.	The contractor must furnish the Landlord with a list of all subcontractors including emergency phone and/or pager numbers prior to commencing the work. 


 

	7.	The contractor must provide an on-site project superintendent at all times that construction work is underway. This supervisor must be knowledgeable of the project’s scope of work and have adequate on-site
reference materials including plans, specifications and MSDS information on all materials used in the performance of the work. 


  
 



 
 H-5 









 



 
  
  

 


	8.	All workers must be dressed appropriately (appropriate dress will include hard hat, appropriate foot ware, etc.) to meet building safety standards that have been provided to Tenant in writing. Shirts must be worn at all
times. No shorts are permitted. 

  

	9.	All carts must be furnished with pneumatic tires and rubber bumpers. 

  

	10.	Smoking is not allowed in the building. 

  

	11.	The use of radios is prohibited. 

  

	12.	Prior to the start of work, all blinds must be raised and bagged, all windowsills and other base building components must be adequately protected and the protection must be maintained. Workers must not stand on
windowsills or other building components. 

  

	13.	Any work that requires access to another tenant’s space must first be coordinated through the Landlord. 

  

	14.	Dumping of construction debris into building drains, mop sinks, trash dumpsters, etc. is strictly prohibited. If this does occur, the contractor shall be charged 200% of the cost of clearing any drain, including
administrative time, where evidence of this is found. 

  

	15.	Base building restrooms within the construction area will be available for use by the contractor unless landlord dedicates an alternate location. Contractor shall be responsible for any damage to the restrooms and for
cleaning and stocking during construction. All other base building restrooms shall be locked and are not to be used by construction personnel. 

  

	16.	Use of the building stairwells for moving construction materials and construction personnel shall be limited to the stairwell designated by Landlord. No material may be brought through the Building lobby. Any damage
done to the stairwell (rails, doors and frames, sheetrock, ceilings etc.) shall be repaired by the Tenant contractor at its sole expense to the satisfaction to the Landlord. 


 

	17.	The contractor shall repair all construction disturbed by the new tenant work or damaged by the contractor’s or subcontractor’s personnel. 


 

	18.	After initial occupancy of the building, no work will be performed from 8:00 am to 8:00 pm Monday through Friday and 9:00 am to 4:00 pm Saturday that will disturb or inconvenience any existing tenants in the building
(e.g. core drilling, shooting track, noxious odors, etc.). The Landlord must preapprove any work that entails noise, vibration or noxious odors. 

  

	19.	All structural revisions, including but not limited to penetrations of slabs, are to be reviewed by Landlord’s engineer. 

  

	20.	Any roof related work must be performed by the roofing contractor designated by the Landlord. 


  
 



 
 H-6 









 



 
  
  

 


	21.	The contractor shall immediately report all accidents to the Landlord in writing after first notifying the Landlord by telephone. 

  

	22.	Landlord shall provide the name of the manufacturer of lockset and key cores for compatibility with building master keying system. 


Part B: Life Safety 
  

	1.	Contractor shall furnish Landlord one set of sprinkler shop drawings and hydraulic calculations for approval by the Landlord’s insurance company once they are completed by subcontractor and ready for submittal to
the Fire Marshall. Once approved by the Fire Marshall, the contractor shall furnish Landlord one set of the approved sprinkler shop drawings. 

  

	2.	Contractor will not disconnect, tamper with, delete, obstruct, relocate, or expand any life safety equipment, except as indicated on drawings approved by the Landlord. Contractor shall not interfere with or delay any
other inspections scheduled prior to Contractors inspections or testing. 

  

	3.	The contractor must take necessary precautions to prevent accidental fire alarms. Any fees or costs charged to the Landlord by the local fire department that arise from accidental fire alarms caused by the contractor
will be paid by the contractor. The Landlord strongly suggests that, during any work that increases the likelihood of an accidental fire alarm such as demolition or sprinkler work, a person approved by the Landlord be designated to “watch”
the fire alarm panel. 

  

	4.	Any unit or device temporarily incapacitated will be red-tagged “Out of Service” and the Landlord will be alerted prior to the temporary outage. 


 

	5.	The base building fire alarm system shall monitor all tenant installed special fire extinguisher/alarm detection systems. The connections to the base building fire alarm system will be at the tenant’s expense. To
the extent the Premises are occupied, or same is otherwise required under Legal Requirements, fire “watch” shall also be provided by tenant contractor during any period fire alarm system is placed out of service for work or connection to
base building. 

  

	6.	All Tenant installed fire alarm initiation and notification devices that connect with the base building fire alarm system shall match the base building system and be approved by the Landlord. 


 

	7.	All connections to the building’s existing fire alarm system are to be made only by the subcontractor specified by the Landlord. 


 

	8.	All fire alarm testing will be scheduled at least 72 hours in advance with the Landlord and other contractors and must occur after normal business hours if the building is occupied. 


  
 



 
 H-7 









 



 
  
  

 


	9.	Combustible and hazardous materials are not allowed to be stored in the building without prior written approval of the Landlord. Material safety data sheets on all materials to be stored in the building must be kept on
site and a copy submitted to the Landlord. 

  

	10.	Dust protection of smoke detectors must be installed and removed each day (if operational). Dust protection is required during construction to avoid false fire alarms and damaging of detector system. Filter media must
be installed over all return air paths to any equipment rooms prior to demolition. The media must be maintained during construction and removed at substantial completion. 


 

	11.	The building is to be fully protected by automatic sprinkler systems in accordance with Landlord’s standards and specifications. 


 

	12.	All sprinkler systems and equipment are to be designed and installed in accordance with the current standards of the National Fire Protection Association. 


 

	13.	All equipment, devices and materials used in the installation must be listed by UL and FM Approved. 

  

	14.	Connections to the base building sprinkler system/standpipe riser shall be provided with a control valve and water flow alarm device. Sprinkler system control valves shall be UL Listed and FM Approved, clockwise
closing, indicating valves with supervisory switches. 

  

	15.	All corrective work to the fire alarm system due to the contractor’s work shall be charged to the contractor. 

  

	16.	All fire alarm wiring in public areas (outside of Tenant demising walls) shall be in rigid conduit. 

 Part
C: Parking – Loading Dock 
  

	1.	Contractors, subcontractors and their personnel will not use the loading dock area for parking without first obtaining permission from the Landlord 24 hours in advance to assure dock availability. Unauthorized vehicles
will be ticketed and towed. 

  

	2.	Use of the loading dock for deliveries/trash removal must be scheduled through the Landlord. 

  

	3.	Material that does not fit into the service elevator must be delivered through a window opening. The contractor will be required to properly remove and replace the glass and to adequately protect the window framing with
prior approval from the Landlord. 

  

	4.	Any instance that requires the removal and replacement of exterior glass, must be approved by Landlord and performed by Landlord approved contractor. 


  
 



 
 H-8 









 



 
  
  

 

 Part D: Utilities 
  

	1.	Utilities (i.e. electric, gas, water, telephone/cable) must not be cut off or interrupted without 48 hour notice and written permission of the Landlord. 


Part E: Security 
  

	1.	The contractor will be responsible for controlling any keys or access cards furnished by the Landlord and will return them to the Landlord. 


 

	2.	The contractor will be responsible for locking any secure area made available to the contractor whenever that area is unattended. 

  

	3.	Contractors may be required to wear identification badges, in which case the badges will be issued by the Landlord to the contractor. 


Part F: Elevators 
  

	1.	No passenger elevators will be used to move construction material or construction personnel. 

  

	2.	The passenger/service elevator can be used to move construction personnel at any time during the day, provided the elevator doors are not held open. The service elevator can not be used to move construction materials
into the building during building operating hours between the hours of 8:00 am and 8:00 p.m. unless approved in writing by Landlord. All other usage must be scheduled with the Landlord with at least 48 hours notice. 


 

	3.	Any costs to repair damage to the elevators including dust or dirt in machine rooms or shaft or costs for service calls resulting from the contractor’s operations will be charged to the contractor.


  

	4.	Any work on the elevators, call buttons and signal lanterns must be approved by Landlord and coordinated with building management. 


Part G: Cleaning 
  

	1.	The contractor will remove all trash and debris daily or as often as necessary to maintain cleanliness in the building. The building trash compactors or containers are not to be used for construction debris.


  

	2.	Walk-off mats or other protection must be provided at door entrances where work is being performed. 


  
 



 
 H-9 









 



 
  
  

 


	3.	Carpeting shall be protected by plastic runners or hardboard as necessary to maintain cleanliness and to protect carpets from damage. 


 

	4.	Tile, terrazzo and wood floors shall be protected from damage as necessary. 

  

	5.	Contractor will furnish a vacuum(s) with a supply of clean bags and an operator to facilitate ongoing clean-up. 

  

	6.	Trash removal will be scheduled and coordinated with the Landlord and undertaken only through the service elevator. 

  

	7.	Contractors must remove all food cartons and related debris from the work area on a daily basis. 

  

	8.	Driveway and street cleaning by Contractor will be required when Contractor’s work has created mud or debris. 


Part H: Mechanical and Electrical Work 
  

	1.	Before any new electrical or mechanical equipment is installed in the building, the contractor must submit a copy of the manufacturer’s data sheets along with complete shop drawings and submittals to the Landlord
for approval. 

  

	2.	Any installation or modification to building HVAC or electrical systems must be first submitted to the Landlord for review. This includes base building systems as well as supplemental units and/or exhaust systems.


  

	3.	The mechanical and electrical plans must be prepared by a licensed engineer and engineer and must show size and location of all supply and return grilles. We may require that the Landlord’s MEP engineer review the
MEP drawings. In that event the tenant will pay for the cost of this review. We will notify the tenant prior to engaging the Landlord’s engineer. 

  

	4.	Contractors modifying ductwork, air grilles, VAV boxes, etc., must balance the air and water systems as necessary. All air balancing is to be done in the presence of the Landlord. Two copies of all balance reports shall
be submitted to Landlord for review and approval. 

  

	5.	Any domestic or condenser water connections made to the building’s piping system, must include a high quality isolation valve, (brass bodied gate or ball-type) and adequate system drain valves. If the system piping
is of a different material a dielectric union must be installed. All valves and equipment must be easily accessible; access doors are required in drywall or other fixed construction. 


 

	6.	Exhaust fans from cooking areas may not discharge into a return ceiling plenum. Such fans will be ducted to the outside via exhaust shafts or other routes as approved by the Landlord. 


  
 



 
 H-10 









 



 
  
  

 


	7.	Where independent tenant-owned air conditioning units are installed, an electric submeter with a output that is compatible with the base building management system must be used or a flat rate electricity charge will be
paid by the Tenant based on anticipated consumption. 

  

	8.	The installation of tenant equipment (except emergency lighting per code) on the base building emergency power supply systems is not permitted. Tenant may seek Landlord review and approval for special circumstances.


  

	9.	Any existing mechanical or electrical systems and their controls that are to remain shall be properly commissioned. That is, at the beginning of the job the systems will be turned over to the contractor in working
condition by the Landlord. Before beginning any work, the contractor should inspect the mechanical or electrical systems and their controls to ensure their working condition. The contractor should advise the Landlord of any noted deficiencies. At
the end of the job, the contractor will be responsible for the proper operation of the mechanical and electrical systems. If the contractor fails to note any deficiencies at the outset of the job, the contractor will, nevertheless, be required to
correct the problems before the Landlord accepts the system. 

  

	10.	All circuit breaker panels must be clearly and accurately identified with typed labels. 

  

	11.	Tenant shall properly protect any of its mechanical equipment with prefilters, dust covers etc. prior to start of work, and shall not disturb any similar prefilters and covers covering base building mechanical
equipment. Protection shall be removed and equipment wiped down at completion. 

  

	12.	Energy management and building control work is to be performed by Landlord’s designated subcontractor. 

  

	13.	Tenant installed equipment that supplements existing base building equipment such as VAV boxes, fire alarm devices, control work etc., shall be identical to the existing base building equipment to facilitate warranty
and maintenance operations. 

  

	14.	All concealed equipment shall be located with necessary accessibility for maintenance and repair. 

  

	15.	Contractor shall contract Landlord 48 hours in advance for Landlord wall and ceiling close-in inspectors. 

  

	16.	No flexible conduit installed in the electrical closets. All runs inside the closet must be electrical metallic tubing (EMT). 


  
 



 
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 Section II: Insurance Requirements for Tenant Contractors 

Introduction 
 Tenant’s Contractors shall procure and
maintain for the duration of the contract insurance against claims for injuries to persons or damages to property which may arise from or in connection with the performance of the work hereunder by the contractor, his agents, representatives,
employees, or subcontractors. The cost of such insurance shall be included in the contractor’s bid, unless otherwise specified. 
 Part A: Minimum
Scope of Insurance 
 Coverage shall be at least as broad as: 
  

	1.	Insurance Services Office “occurrence” form CG 00 01 (ed. 10/93) covering commercial general liability or its equivalent. 

  


	2.	Insurance Services Office form CA 00 01 (ed. 6/92) covering automobile liability, coverage must apply to all owned, non-owned and hired vehicles. 


 

	3.	Workers compensation insurance as required by labor code of the jurisdiction in which the Building is located, and employers liability insurance. 


Part B: Minimum Limits of Insurance 
 Contractor shall
maintain limits no less than: 
  

	1.	Commercial general liability: $1,000,000 combined single limit per occurrence for death, bodily injury and property damage. Minimum $2,000,000 aggregate. (The general aggregate limit shall apply separately to this
project/location or the general aggregate shall be twice the required limit.). 

  

	2.	Automobile liability: $1,000,000 per person/$2,000,000 per accident for death, bodily injury and property damage. 

  

	3.	Workers compensation and employers liability: Workers compensation limits as required by the labor code of the jurisdiction in which the Building is located and employers liability limits of $1,000,000 per accident.


  

	4.	Umbrella Liability: $5,000,000 per occurrence and $5,000,000 aggregate (The aggregate limit shall apply separately to this project/location). 


Part C: Coverages 
  

	1.	General Liability and Automobile Liability Coverage 

 (a) The managing agent of the Building,
the holder of any mortgage, and their respective officers and employees are to be covered as additional insureds as respects: liability arising out of activities performed by or on behalf of the contractor; products and completed operations of the
contractor; premises owned, leased, or used by the contractor; or automobiles owned, leased, hired, or borrowed by the contractor. 

  
 



 
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 The coverage shall contain no special limitations on the scope of protection afforded. 

(b) The contractor’s insurance coverage shall be primary insurance as respects the Landlord, its officers, officials, and employees. Any
other insurance or self-insurance maintained by the Landlord, its officers, officials, and employees shall be excess of and not contribute with the contractor’s insurance. 

(c) Any failure to comply with reporting provisions of the policies shall not affect coverage provided to the agency, its officers, officials,
and employees. 
 (d) The contractor’s insurance shall apply separately to each insured against whom claim is made or suit is brought
except with respect to the limits of the insurer’s liability. 
 The insurer shall agree to waive all rights of subrogation against the
Landlord, its officers, officials, and employees for losses arising from work performed by the contractor for the Landlord. 
 Part D: All Coverages

 Each insurance policy required by this clause shall be endorsed to state that coverage shall not be suspended, voided, canceled by either party,
reduced in coverage or in limits except after 30 days’ prior written notice by certified mail, return receipt requested, has been given to the city. 

Part E: Acceptability of Insurers 
 Insurance is to be
placed with insurers licensed to do business in the jurisdiction in which the Building is located, that have been approved in advance by the Landlord, with a Best’s rating of no less than A:XI unless specific approval has been granted by the
Landlord. 
 Part F: Verification of Coverage 

Contractor shall furnish the Landlord with certificates of insurance evidencing the coverages required by this Article. The certificates for each insurance
policy are to be signed by a person authorized by that insurer to bind coverage on its behalf. The certificates are to be on ACORD Form 27 and/or ACORD Form 25-S, or other forms 

  
 



 
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that are similarly binding on insurers, which forms are to be received and approved by the Landlord before work commences. In addition, the Landlord shall require an endorsement naming the
Landlord, the managing agent of the Building, the holder of any mortgage and their respective officers and employees as additional insureds or loss-payees (whichever is applicable). The Landlord reserves the right to require Tenant to deliver
complete, certified copies of all required insurance policies, at any time. 
 Part G: Subcontractors 

Contractors shall include all subcontractors as insureds under their policies or shall furnish separate certificates for each subcontractor in the form
described in clause E above. All coverage for subcontractors shall be subject to all of the requirements stated herein. Commercial general liability coverage shall include independent contractors coverage, and the contractor shall be responsible for
assuring that all subcontractors are properly insured. 

  
 



 
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 Section III: Close-Out Requirements for Tenant Contractors 

The following are required from the general contractor prior to final payment being made: 

 

	1.	Two complete sets of all Operations and Maintenance Manuals bound in notebooks with an index, as specified in the project manuals. 

  

	2.	Two sets of blackline prints and one(1) CADD.DWG disk file including architectural, structural, plumbing, fire protection, elevator, mechanical, and electrical drawings. The as-built drawings must include modifications
made to the specifications, schedules and details and all changes initiated by requests for information and field orders. 

  

	3.	Copies of all building permits and certificates of occupancy, or occupancy permits. 

  

	4.	Final Releases of Liens from the general contractor and all subcontractors. 

  

	5.	One copy of all warranties bound in notebooks with a corresponding warranty log. 

  

	6.	One complete set of all approved submittals and shop drawings and a copy of the final submittal log. 

  

	7.	A complete list of all persons, including names, addresses, phone numbers and contact persons that will be providing warranty service during the warranty periods. 


 

	8.	One copy of NEBB certified air and water balancing reports. 

  

	9.	When the general contractor considers the work to be ready for final acceptance, written certification from the general contractor shall be submitted stating the following: 


 

	(a)	Work has been completed in accordance with the contract documents and Tenant Plans; 

  

	(b)	All punch list items and other deficiencies identified by the Certificate of Substantial Completion have been corrected; 

  

	(c)	Work has been inspected for compliance with the contract documents and Tenant Plans; 

  

	(d)	All mechanical and electrical equipment and systems have been tested in the presence of the Landlord’s representative and are operational. 


  
 



 
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 1.0 Ceiling 

1.1 All tile and grid shall be standard white, Class A fire rated, and contain recycled content. 

1.2 Perimeter Soffit detail shall be constructed as follows: 
  





 
 2.0 Wall Finishes 

Suggested Guidelines 
 2.1 All partitions shall
be finished with paint and standard base unless alternate is proposed. 
  

	(a)	Standard resilient wall base shall be 2 1 / 2” high. Cove base shall be used at all resilient or exposed flooring. Straight base shall be used at all carpeted flooring. 


  
 



 
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 3.0 Doors/Hardware 

Suggested Guidelines 
 3.1 Suite Entry –
Glass Double Doors. Doors shall be 3’x8’, 1 / 2 “ frameless glass with polished edges and top and bottom rails. Hardware shall include vertical pull bar with back to back mounting through door, a recessed and concealed header, and
door closer. Standard hardware to be brushed stainless steel. 
 3.2 Corridor Wood Doors. Doors shall be 3’x8’. Doors shall be flush,
solid-core, paint-grade wood door with aluminum frame assembly. Doors shall have mortised locksets and be equipped with a recessed, concealed header and door closer. Standard hardware to be brushed stainless steel. 

3.3 Interior Wood Doors. Doors shall be 3’x8’. Doors shall be flush, solid-core, paint-grade wood door with aluminum frame assembly. Doors shall
have butt hinges, cylindrical locksets and be equipped with a surface mounted door closer. Standard hardware to be brushed stainless steel. 
 4.0
Lighting 
 Suggested Guidelines 
 Use of
indirect pendant mounted ambient lighting system to reflect off high ceiling is preferred, with a design work surface illumination level of 25 – 30 foot-candles. 

Use of LED lighting is recommended for task lighting; 

Use light colored ceiling materials to reflect indirect lighting 

5.0 Partitions 
 Suggested Guideline 

Use low partitions (below 42”) to promote better lighting/day lighting and allow views to perimeter whenever possible 

  
 



 
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 In an attempt to maximize natural day lighting the use of light shelves and reflective ceiling materials
is encouraged to bounce light deep within the building. 
 6.0 Suite Entry Signage 

Subject to Article 24 of the Lease. 
 7.0 Window Blinds

 In accordance with landlord specified treatments. 

8.0 Flooring 
 Carpet and vinyl flooring adhesive to be
low VOC. 
 9.0 HVAC 
 9.1 See Building Shell Definition

 9.2 Subject to Landlord approval, Tenant may elect to install supplemental HVAC systems. All supplemental HVAC systems shall be sub metered. Supplemental
HVAC is not included in the turnkey cost – and would be paid for by Tenant. 
 10.0 Telephone/Data 

10.1 Pull string and trim ring at locations determined by Tenant. Entire cable plant will be contracted for directly between the Tenant and their vendor. 

10.2 All necessary communications equipment is the responsibility of the Tenant and shall be located completely with Tenant space. 

  
 



 
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 11.0 General Plumbing Requirements 

 
 



 
  
 



 

  
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 Part A: Introduction and General Information 

Why Green? 
 Buildings in the United States consume over
80% of the total electricity and more than 30% of total energy used annually. Buildings also utilize significant amounts of fresh water during both construction and occupancy. Material waste during construction accounts for up to 53% of landfill
waste, depending on location. A well designed, sustainable building works to reduce impact on the environment while garnering financial and health-related benefits for the Owner and Tenants. 

Currently, people spend over 90% of their time in buildings – much of that time at work. One benefit of a green building for occupants is the more
comfortable and controllable environment designed into sustainable buildings. The impact of such an attribute can be manifested in increased employee retention and productivity. 

United States Green Building Council and LEED 
 The United
States Green Building Council (USGBC) is a nonprofit organization committed to expanding sustainability in the built environment. Its mission is to transform the way buildings and communities are designed, built and operated, enabling an
environmentally and socially responsible, healthy, and prosperous environment that improves the quality of life. LEED (Leadership in Energy and Environmental Design) is a voluntary, consensus-based national rating system for developing
high-performance, sustainable buildings. 
 Developed by the USGBC, LEED addresses all building types and emphasizes state- of-the-art strategies for
sustainable site development, water savings, energy efficiency, materials and resource selection, and indoor environmental quality. LEED is a voluntary rating system for green building design and construction that provides immediate and measurable
results for building owners and occupants. 
 Opportunities for Tenants 

Tenants at 150 Second have a remarkable opportunity to help lead the shift to sustainability in buildings, and in the process define a new kind of workplace.
By locating in a LEED Gold building, tenants will benefit from a high performance building with excellent indoor air quality and ample daylight and views. These and other elements combine to create a healthier workplace and improve the indoor
environment for all 

  
 



 
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employees. In addition, 150 Second has set a higher standard with high-performance technologies that use less energy, consume less water, and leave a smaller footprint on the city’s
resources. Some of the building’s innovative features will be noticed at once: low flow plumbing fixtures and the zero irrigation rain garden. Others, such as energy-saving base building mechanical systems will exist behind the scenes, quietly
but significantly setting the building apart from its neighbors. 
 The LEED Guidelines that follow summarize the measures that Skanska has taken to achieve
LEED Gold certification for 150 Second. These guidelines are intended to help tenants understand and take full advantage of the high-performance features of the building, and to provide guidance in ways that tenants can reinforce these features in
their own workplaces. 
 Skanska set a goal of achieving LEED Gold for the base building at 150 Second using LEED for Core and Shell (LEED-CS) version 2009.
We can only design and build the building, however. It is up to our tenants to fit it out and operate it in an environmentally friendly way. To do this, we recommend you use the LEED for Commercial Interiors (LEED-CI) rating system. The intent of
LEED-CI is to assist in the creation of high-performance, healthy, durable, affordable and environmentally sound commercial interiors. Together LEED-CS and LEED-CI address the commercial office real estate market for both developers and tenants
enabling significant benefits through improved indoor air quality, maximized day lighting and lower energy costs. A copy of the LEED 
 -CI 2009 Scorecard
and link to the Rating System are included in Appendix A for reference by tenants who wish to explore more information on timing and detailed strategies. 

  
 



 
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 Project Data 
  

			
	Floor Area:	  	123,210 rentable square feet (total)
		
	Occupancy Group:	  	Group S-2, Low Hazard Storage (Parking Garage)
		
		  	Group B, (30%) and Lab areas (70%)
		
	Construction Type:	  	IB
		
	Building Address:	  	 150 Second Street
 Cambridge, MA
02141


 Part B: LEED-CD and LEED-CI Certification 

Base Building Certification at 150 Second 
 The LEED
Guidelines that follow summarize the measures Skanska has undertaken to achieve LEED certification under the LEED for Core and Shell (LEED-CS) rating system. It is intended to help tenants understand and take full advantage of the high-performance
features of the building, and to provide guidance to assist tenants in reinforcing these features in their own workplaces. It will also provide tenants with guidance and information on achievement of LEED for Commercial Interiors (LEED-CI). 

Sustainable Sites (SS) 
 The LEED requirements for the
Sustainable Sites category are predominantly base-building responsibilities. A tenant applying for LEED for Commercial Interiors (LEED-CI) certification automatically gains five credits simply by choosing to be a tenant in the LEED-CS building at
150 Second. 
 SSp1: Erosion and Sedimentation Control 

Intent Reduce pollution from construction activities by controlling soil erosion, water-way sedimentation and airborne dust generation. 

LEED-CS This prerequisite is normally required as a routine part of the site design and city entitlement process. 150 Second complied with the
requirements of this prerequisite 

  
 



 
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by developing and adhering to a Stormwater Pollution Prevention Plan as required by the United States Environmental Protection Agency. Tenants benefit by knowing that the construction process of
the LEED-CS building had minimal negative impact on the local environment in terms of loss of soil, sedimentation of local storm-sewer systems, and localized air pollution. 

LEED-CI No related LEED-CI credit. 
 SSc1: Site
Selection 
 Intent Avoid development of inappropriate sites and reduce the environmental impact from the location of a building on the site. 

LEED-CS 150 Second meets all of the stated criteria for this credit. By developing in a dense, urban neighborhood, urban sprawl is reduced, as is the
pressure to develop in environmentally sensitive areas. The LEED-CS building did not develop on prime farmland, within a flood plain, near wetland areas, on land protected for endangered species, or on former public parkland. Location by the tenant
in 150 Second helps to preserve these valuable environmental resources. 
 LEED-CI No related LEED-CI credit. Tenants attempting LEED-CI at 150
Second will earn five points for locating in a LEED-CS building. This is associated with LEED-CI SSc1: Site Selection. 
 SSc2: Development Density and
Community Connectivity 
 Intent Channel development to urban areas with existing infrastructure to protect greenfields, and persevere habitat and
natural resources. 
 LEED-CS 150 Second is located on a previously developed site, within one-half mile of a dense residential zone and within close
pedestrian access to more than ten basic community services. Pedestrians also have easy access to all community services. Tenants benefit from the close proximity of numerous services such as restaurants, shopping, and groceries. The close proximity
of neighborhood and community services help to reduce pollution caused by the use of motor vehicles. 150 Second also meets the development density path of this credit. 

  
 



 
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 LEED-CI Tenants attempting LEED-CI at 150 Second will earn six LEED-CI points through SSc2:
Development Density and Community Connectivity. 
  
 



 
 SSc3: Brownfield Redevelopment 

Intent Remediate and redevelop sites deemed as contaminated in order to restore the health of the site and avoid development of greenfield sites. 

LEED-CS 150 Second is located on a site that was previously contaminated. The site has been remediated. Remediation and redevelopment of brownfield
sites is a huge undertaking by a developer, and Skanska is proud to have redeveloped this site and make it suitable for living and working conditions. 

LEED-CI Brownfield redevelopment is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 

SSc4.1: Alternative Transportation-Public Transportation Access (LEED-CI SSc3.1) 

Intent Locate project near public transportation to reduce the number of vehicles on the road and to reduce land redevelopment for parking. 

  
 



 
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 LEED-CS 150 Second is located within one-quarter mile walking distance of the Lechmere T stop and
multiple bus lines. Locating in close proximity to rail and multiple bus lines is beneficial to tenants and their visitors because of the convenience of public transit access. This also reduces the need to drive cars to the site, thereby reducing
environmental impacts associated with pollution and development. 
 LEED-CI Tenants attempting LEED-CI at 150 Second will earn six points meeting the
credit requirements of SSc3.1: Alternative Transportation-Public Transportation Access in the LEED-CI rating system. 
 SSc4.2: Alternative
Transportation – Bicycle Storage and Changing Rooms 
 (LEED-CI SSc3.2) 

Intent Include bike racks and showering facilities to encourage building occupants to bike to the site, in an effort to reduce the number of vehicles on
the road and to reduce land development for parking. 
 LEED-CS 150 Second provided 22 long-term and 8 exterior bike storage spaces for an estimated
>8% of the assumed building users and provided 2 shower and changing rooms. This exceeds the requirement of racks for 3% of all building users and provided showering for an estimated 0.5% of full-time equivalent (FTE) occupants 

LEED-CI Tenants attempting LEED-CI at 150 Second may be able to earn two points for LEED-CI SSc3.2: Alternative Transportation-Bicycle Storage and
Changing Rooms. However, LEED-CI projects must provide bike racks for 5% of tenant occupants and showers for 0.5% of FTE. Tenants should verify that the bike racks and showers provided in the base building meet the required numbers for the tenant
space. The base building provides sufficient bike storage to satisfy the requirements for 600 total peak users and changing facilities for 400 total FTE’s. 

  
 



 
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 SSc4.3 Alternative Transportation – Low-Emitting and Fuel-Efficient Vehicles 

Intent Encourage the use of low-emitting and fuel-efficient (LE/FE) vehicles by providing preferred parking spaces for LE/FE vehicles. 

LEED-CS 150 Second will offer 5 preferred spaces for vehicles that meet the LEED definition of Low-Emitting and Fuel Efficient Vehicles. 

LEED-CI There is no related LEED-CI credit. 
 SSc4.4:
Alternative Transportation – Parking Capacity (LEED-CI SSc3.3) 
 Intent Minimize parking spaces and provide preference to carpool and
vanpool vehicles, in an effort to reduce the number of vehicles on the road and to reduce land development for parking. 
 LEED-CS 150 Second
minimized the total parking capacity to not exceed local zoning requirements but was not required to provide preferred parking for carpools or vanpools to meet the credit requirements. Parking capacity was minimized in an effort to reduce land
development. 
 LEED-CI Tenants attempting LEED-CI at 150 Second may be able to earn two points for LEED-CI SSc3.3: Alternative Transportation –
Parking Availability, which requires minimized parking for tenants and preferred parking for carpools and vanpools. Tenants in a LEED-CS building do not automatically meet this credit and will have to determine the maximum number of parking spaces
available to them and provide the preferred parking spaces. See the LEED-CI Rating System for exact requirements. 
 SSc5.1: Site Development –
Protect or Restore Habitat 
 Intent Conserve native habitat in an effort to promote biodiversity. 

LEED-CS 150 Second did not pursue this credit. 

LEED-CI There is no related LEED-CI credit. 
 SSc5.2:
Site Development – Maximize Open Space 
 Intent Provide a high ratio of open space to development footprint to promote biodiversity. 

  
 



 
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 LEED-CS Although 150 Second did not pursue this LEED credit, the Project increased the amount of
vegetated open space which provides tenants with added amenities and park space. 
 LEED-CI There is no related LEED-CI credit. 

SSc6.1: Stormwater Design – Quality Control 

Intent Limit disruption of natural hydrology by reducing impervious cover, increasing onsite infiltration, and managing stormwater runoff quantities.

 LEED-CS 150 Second implemented a stormwater management plan that reduced the stormwater runoff by 25% compared to pre-development volumes. Tenants
and the local community benefit from the stormwater management plan due to less stormwater runoff and less contamination entering local waterways. Post development conditions show 44.92% reduction in 2 year, 24-hour design storm. 

LEED-CI Stormwater management is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 

SSc6.2: Stormwater Design – Quality Control 

Intent Limit disruption of natural hydrology by reducing impervious cover, increasing on-site infiltration, and managing the quality of stormwater
runoff. 
 LEED-CS 150 Second has provided a new stormwater technology that captures and treats stormwater runoff from 90% of the annual rainfall and
removes at least 95.58% of total suspended solids. Tenants and the local community benefit from the stormwater management plan due to less stormwater runoff and less contamination entering local waterways. 

LEED-CI Stormwater management is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 

SSc7.1 Heat Island Effect – Nonroof 
 Intent
Reduce heat island effect (thermal gradient differences between developed and undeveloped areas) to minimize impact on microclimate, and human and wildlife habitat. 

  
 



 
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 LEED-CS 150 Second has placed 84% of the total parking capacity under a white roof in an effort to
reduce the heat island effect. By placing the majority of parking spaces under one cover in a stacked parking garage, 150 Second is able to reduce the amount of asphalt required for the same number of parking spaces and therefore minimize local heat
island effects. 
 LEED-CI The heat island effect is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a
LEED-CS building. 
 SSc7.2: Heat Island Effect – Roof 

Intent Reduce heat island effect (thermal gradient differences between developed and undeveloped areas) to minimize impact on microclimate, and human
and wildlife habitat. 
 LEED-CS 150 Second installed a light colored roof which reduces the heat island effect. Tenants will benefit from more
efficient operations of the HVAC system in the building, which is passed on to the tenants in reduced energy costs. 
 LEED-CI The heat island effect
is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 
 SSc8: Light Pollution Reduction

 Intent Reduce the impacts of lighting on nocturnal environments, reduce glare, and minimize light trespass from interior windows. 

LEED-CS 150 Second did not pursue this credit. 

LEED-CI Light pollution reduction is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building.

 SSc9: Tenant Design and Construction Guidelines 

Intent Provide tenants with a descriptive tool that both educates and helps implement sustainable design and construction features in their tenant
improvement build-out. 

  
 



 
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 LEED-CS Tenant Design and Construction Guidelines benefit the LEED-CS certified project for two
important reasons. First, the Guidelines help tenants design and build sustainable interiors and adopt green building practices; second, the Guidelines help in coordinating LEED-CI and LEED-CS certifications. These Guidelines are a tool to enable
tenants of 150 Second to design and implement sustainable, green building interiors that will benefit the overall health and quality of life for building occupants. 

LEED-CI No related LEED-CI credit. 
 Water Efficiency
(WE) 
 WEp1: Water Use Reduction – 20% Reduction and WEc3: Water Use Reduction 

Intent Maximize water efficiency within buildings to reduce the burden on municipal water supply and wastewater systems. 

LEED-CS 150 Second installed base building fixtures to achieve the prerequisite of 20% water reduction but also earned additional points and achieved
an overall water use reduction of 39% for showers, low-flush toilets and low-flush urinals. In total, these measures will reduce water consumption of the building by approximately 250,000 gallons per year. 

LEED-CI Tenants attempting LEED-CI at 150 Second will also need to meet the 20% water use reduction prerequisite. This prerequisite addresses only
toilets, urinals, lavatory faucets, prerinse spray valves and showerheads. 150 Second has ultra low-flow metering lavatories, low-flow showers, low-flow toilets and low-flush urinals that tenants will be using and can take advantage of in compliance
with LEED-CI. The tenant’s participation in this credit guideline could further support reduction of water use. 
 150 Second encourages tenants to
employ water efficient fixtures in other areas of their space such as installing ultra flow faucets (0.5 gpm) in pantry/kitchenette laboratory and/or prerinse spray valves below the baseline. By employing similar strategies for the tenant space, the
tenant has the opportunity to achieve up to 11 points for WEc1: Water Use Reduction within the LEED-CI rating system. 

  
 



 
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 Goals for Tenant Water Fixtures: 
  

	•	 	Low Flow Water Closets (1.28 gpf) – Already in core toilet rooms. 

  

	•	 	Pint Flush Urinals (0.125 gpf) – Already in core toilet rooms. 

  

	•	 	Ultra Low Flow Metering Lavatories (0.83 g/cycle) – Already in core toilet rooms. 

  

	•	 	Ultra Low Flow Kitchen and Janitorial Sinks (1.0 gpm) 

  

	•	 	Ultra Low Flow Shower Fixtures (1.5 gpm) – Already in core shower rooms. 

  

	•	 	Residential Dishwashers (Energy Star) 

  

	•	 	Commercial Dishwashers (1.0 gallons/rack) 

  

	•	 	Residential Clothes Washers [4.5 WF (gallons/ft 3 /cycle)] 

  

	•	 	Commercial Clothes Washer [7.5 WF (gallons/ft 3 /cycle)] 

 WEc1: Water Efficient Landscaping 

Intent Reduce potable water consumption for irrigation through the use of high-efficient technologies and low-water consuming plantings. 

LEED-CS 150 Second installed limited turf grass and drought-resistant plants that require no permanent irrigation. These measures have resulted in a
100% potable water use reduction for irrigation. 
 LEED-CI Water-efficient landscaping is covered under LEED-CI SSc1: Site Selection, where tenants
earn five points for locating in a LEED-CS building. 
 WEc2: Innovative Wastewater Technologies 

Intent Reduce wastewater generation and minimize the impact on municipal wastewater treatment plants. 

LEED-CS 150 Second installed an onsite rainwater storage system that treats water to tertiary standards. The treated rainwater is then reused for the
toilets and urinals. This rainwater storage system reduces water use for toilets and urinals by 85%. 
 LEED-CI Innovative wastewater technologies
are covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 

  
 



 
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 Energy and Atmosphere (EA) 

EAp1: Fundamental Commissioning and EAc3: Enhanced Commissioning 

(LEED-CI, EAc2: Enhanced Commissioning) 
 Intent

 Fundamental: To verify that the project’s energy-related systems are installed, calibrated and perform according to the
owner’s project requirements, basis of design and construction documents. Benefits of commissioning include reduced energy use, lower operating costs, reduced contractor callbacks, better building documentation, improved occupant productivity
and verification that the systems perform in accordance with the owner’s project requirements. 
 Enhanced: To begin the commissioning
process early in the design process and execute additional activities after systems performance verification is completed. 
 LEED-CS 150 Second
performed enhanced commissioning of all base building energy systems, including base building HVAC system and controls, domestic hot water, core and lobby lighting systems and controls and building management system. This process helped to assure
all energy-related systems are operating as intended. 
 LEED-CI Tenants attempting LEED-CI at 150 Second are required to perform fundamental
commissioning of their energy-related systems. Additionally, tenants can achieve five points if they elect to perform enhanced commissioning (EAc2). 

EAp2: Minimum Energy Performance 
 Intent To
establish the minimum level of energy efficiency for the proposed building and systems to reduce environmental and economic impacts associated with excessive energy use. 

LEED-CS 150 Second performed whole building energy simulation using ASHAE 90.1-2007 Appendix G and has met the requirements for energy performance. 150
Second energy simulation demonstrated an improvement of 43% over ASHRAE 90.1-2007. The building envelope was designed to improve energy efficiency and reduce the cost of energy for the entire building, these savings are passed on to the tenant. 

LEED-CI Minimum Energy Performance of the tenant space is a prerequisite in the LEED-CI rating system CAp2. Tenants attempting LEED-CI at 150 Second
are required to comply with the mandatory provisions and prescription requirements of ASHRAE 90.1-2007, as well as reduce connected lighting power density by 10% from ASHRAE 90.1-2007 and install Energy Star appliances for at least 50% of eligible
equipment. Tenants occupying space in 150 Second will benefit from the energy efficiencies of the base building systems but will not be automatically guaranteed credit compliance. 

  
 



 
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 EAp3: Fundamental Refrigerant Management 

Intent To reduce stratospheric ozone depletion. 

LEED-CS 150 Second installed new HVAC systems which contained no Chlorofluorocarbon (CFC)-based refrigerants which thereby reduce the buildings impact
on the ozone. 
 LEED-CI Tenants attempting LEED-CI at 150 Second are required to comply with this prerequisite through either the purchase of new
HVAC equipment which contains no CFC-based refrigerants or upgrading of existing equipment which contains CFC-based refrigerants. 
 EAc1: Optimize
Energy Performance 
 Intent To achieve increasing levels of energy performance beyond the prerequisite standard and to reduce environmental and
economic impacts associated with excessive energy use. 
 LEED-CS 150 Second performed whole building energy simulation using ASHAE 90.1-2007
Appendix G and has met the requirements for energy performance. 150 Second energy simulation demonstrated an improvement of 43% over ASHRAE 90.1-2007. 

LEED-CI Tenants attempting LEED-CI at 150 Second can earn points for further enhancing energy efficiency. These combined strategies will contribute
toward further reductions in environmental and economic impacts for the project. Points are achievable across different areas of energy related systems as follows: 

EAc1.1: Optimize Energy Performance – Lighting Power: Projects can achieve up to five points for further reductions in lighting
power density below ASHRAE 90.1-2007. 
 Recommendations for Tenant Lighting Systems: 

 

	 	•	 	Display lighting: metal halide, fluorescent, or LED lamps rather than halogen. 


  
 



 
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 EAc1.2: Optimize Energy Performance – Lighting Controls: Projects that install
lightning controls such as daylight and occupancy sensors can achieve up to three points in and contribute towards increased energy conservation. 

Recommendations for Tenant Lighting Controls: 
  

	 	•	 	Install daylight responsive controls in all regularly occupied spaces within 15 feet of windows and under skylights. 


EAc1.3: Optimize Energy Performance – HVAC: Through increased HVAC equipment efficiencies and appropriate zoning and controls,
which result in HVAC performance above ASHRAE 90.1-2007, projects are eligible for up to 10 points. 
 Recommendations for Tenant HVAC
Systems: 
  

	 	•	 	High SEER condensing units – minimum 14 SEER. 

  

	 	•	 	Air source heat pump heating. 

  

	 	•	 	Electronically Controlled Motors (ECM) in fan coils. 

  

	 	•	 	Demand ventilation controls with CO2 sensors. 

 EAc1.4: Optimize Energy Performance –
Equipment and Applications: Selecting energy-efficient equipment and appliances, as qualified by EPA’s Energy Star Program, can contribute up to 4 points. 

EAc2: On-Site Renewable Energy 
 Intent To
encourage and recognize increasing levels of on-site renewable energy self-supply to reduce environmental and economic impacts associated with fossil fuel energy use. 

LEED-CD 150 Second did not pursue this credit. 

LEED-CI On-site renewable energy is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 

EAc5: Measurement and Verification (LEED-CI, EAc3) 

Intent To provide for the ongoing accountability of building energy consumption over time. 

LEED-CS 150 Second did not pursue this credit. 

  
 



 
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 LEED-CI Tenants attempting LEED-CI at 150 Second can earn points by providing ongoing accountability
and optimization of their energy and water consumption over time. 150 Second has provided tenants a lease agreement in which energy costs are paid by the tenants and not included in the base rent, making the tenants eligible for three points in
LEED-CI (EAc3-Measurement & Verification). Furthermore, the base building central monitoring system allows tenants the ability to easily install submetering devices within their space. 

EAc6: Green Power (LEED-CI, EAc4) 
 Intent To
encourage the development and use of grid-source, renewable energy technologies on a net-zero pollution basis. 
 LEED-CS 150 Second did not pursue
this credit. 
 LEED-CI Tenants attempting LEED-CI at 150 Second can earn five points by engaging in a 2 year renewable energy contract through
LEED-CI EAc4. The contract amount must be for at least 50% of the energy consumed in the tenant space for at least 8 kilowatt hours per square foot of tenant space. 

Materials and Resources (MR) 
 MRp1: Storage and
Collection of Recyclables 
 Intent Facilitate the reduction of waste generated by building occupants that is hauled to and disposed of in
landfills. 
 LEED-CS 150 Second provides a centrally located, easily accessible area for recycling of paper, cardboard, glass, plastics and metals,
for the base building and tenant occupants. The recycling storage area is located at Room 119 near the loading dock. 
 LEED-CI Tenants attempting
LEED-CI at 150 Second are provided with an easily accessible dedicated area for tenants recycling (paper, corrugated cardboard, glass, plastics and metals). This is a prerequisite in the LEED-CI rating system (MRp1) and LEED-CI projects will
automatically earn this prerequisite. Tenants are strongly encouraged to create a dedicated recycling area on each floor to facilitate efficient sorting and recycling of waste materials. 

  
 



 
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 MRc1.1: Tenant Space – Long-term Commitment (LEED-CI Only) 

Intent To encourage choices that conserve resources, reduce waste and the environmental impacts of tenants related to materials, manufacturing and
transportation. 
 LEED-CS There is no related LEED-CS credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second are encouraged to pursue a ten-year lease. Doing so will help earn LEED-CI MRc1.1. 

MRc1.2: Building Reuse – Maintain Interior Nonstructural Elements 

Intent To reduce the environmental impact of new construction by salvaging old building stock. 

LEED-CS 150 Second did not pursue this credit. 

LEED-CI Tenants LEED-CI at 150 Second may earn a point for the interior salvage of the floors, walls and doors, as long as tenants preserve these
elements during fit-out. Projects can up to two points for MRc1.2: Building Reuse-Maintain Interior Nonstructural Components for maintain 40% or 60% of interior components. 

MRc2: Construction Waste Management 
 Intent Divert
Construction and demolition debris from disposal in landfills and incinerators. Redirect recyclable recovered resources back to the manufacturing process. Redirect reusable materials to appropriate sites. 

LEED-CS 150 Second implemented a Construction Waste Management Plan that resulted in diverting over 95% of the project’s construction and
demolition waste from being disposed in landfills. 
 LEED-CI Tenants attempting LEED-CI at 150 Second can develop and implement their own
construction waste management plan during the construction of the tenant space, and by recycling 50% or 75% of construction, demolition and packaging debris, tenants can qualify for up to two points for MRc2.1: Construction Waste Management. 

  
 



 
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 MRc3: Materials Reuse (LEED-CI, MR3.1) 

Intent To reduce the environmental impact of new construction by salvaging materials. 

LEED-CS 150 Second did not pursue this credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second can earn up to two LEED-CI points under MRc3.1: Materials Reuse by using salvaged old doors and
windows to make interior partitions, and an additional credit for MRc3.2: Materials Reuse – Furniture and Furnishing for reusing furniture. 

MRc3.2: Materials Reuse – Furniture and Furnishing (LEED-CI Only) 

Intent To reduce the environmental impact of new construction by salvaging materials. 

LEED-CS There is no related LEED-CS credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second can refurnish, reuse or salvage 30% of their total furniture cost to earn an additional LEED-CI point.

 MRc4: Recycled Content 
 Intent Increased
demand for building products that incorporate recycled content materials, thereby reducing impacts resulting from extraction and processing of virgin materials. 

LEED-CS 150 Second specified the use of a minimum of 20% of building materials (by cost) as recycled materials, containing post-consumer or
post-industrial recycled content. 
 LEED-CI Tenants attempting LEED-CI at 150 Second can specify 10% – 20% of materials to have recycled
content, out of the total amount of construction materials and furnishings, the tenant can achieve two LEED points through MRc4: Recycled Content. Consider specifying products such as structural steel, gypsum board and concrete to have high-recycled
content. 
 MRc5: Regional Materials 
 Intent
Increase demand for building materials and products that are extracted and manufactured within the region, thereby supporting the use of indigenous resources and reducing the environmental impacts resulting from transportation. 

  
 



 
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 LEED-CS 150 Second specified the use of a minimum of 10% of building materials (by cost) to be
regionally extracted and manufactured (within 500 miles of the site). 
 LEED-CI Tenants attempting LEED-CI at 150 Second can specify 20% of the
combined value of construction materials and furnishings to be manufactured regionally (within 500 miles of the site) to earn a LEED-CI point for MRc5: Regional Materials. If 10% of those materials are also extracted, harvested or recovered from
within 500 miles of the project, tents earn an additional point under MRc5, Option 2. 
 MRc6: Rapidly Renewable Materials (LEED-CI Only) 

Intent To reduce the environmental impact of finite raw materials that have long-cycles of growth. 

LEED-CS There is no related LEED-CS credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second are encouraged to specify a minimum of 5% of the total value of all building materials from rapidly
renewable sources to earn a LEED-CI point through MRc6: Rapidly Renewable Materials. Rapidly renewable materials are agricultural products, either fiber or animal, which take ten years or less to grow or raise and then harvested in an ongoing and
sustainable fashion. Bamboo, wool, carpets, cork, rubber, strawboard and wheatboard are all examples of rapidly renewable resources. 
 MRc6: Certified
Wood (LEED-CI, MRc7) 
 Intent Encourage environmentally responsible forest management. 

LEED-CS 150 Second specified a minimum of 50% of wood-based products to be harvested in accordance with the Forest Stewardship Council’s (FSC)
Principles and Criteria, for base building wood components. FSC certification means that the forest managers employed environmentally and socially responsible forest management practices. FSC wood has been specified for base building finishes such
as the lobby wall paneling and cabinetry. 
 LEED-CI Tenants attempting LEED-CI at 150 Second are encouraged to specify certified wood for new wood
products and materials for their space. A minimum of 50% of certified wood used in the project is required to achieve a LEED-CI point through MRc7: Certified Wood. 

  
 



 
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 Indoor Environmental Quality (IEQ) 

IEQp1: Minimum Indoor Air Quality Performance 

Intent To establish minimum indoor air quality (IAQ) performance to enhance indoor air quality in buildings, thus contributing to the comfort and
well-being of the occupants. 
 LEED-CS 150 Second has met the requirements of Section 4 through 7 of ASHRAE Standard 62.1-2007, Ventilation for
Acceptable Indoor Air Quality for the base building, and goes beyond the ventilation rates required by the prerequisite to provide 30% more ventilation than required by the ASHRAE standard. The base building HVAC system supports this design by
providing at least 20 cubic feet per minute of outside air per person, based on standard occupancy densities. The tenants from this by increased productivity. 

LEED-CI Tenants attempting LEED-CI at 150 Second are required to supply minimum levels of ventilation through compliance with ASHRAE 62.1-2007.
Depending on the location of the tenant spaces, tenants may need to provide adequate ventilation for their spaces to meet LEED-CI IEQp1: Minimum Indoor Air Quality Performance. Some spaces in the tenant building will automatically comply, others
will need to provide ventilation in their own spaces. Contact building management for details on your tenant space. 
 IEQp2: Environmental Tobacco Smoke
Control 
 Intent To minimize exposure of building occupants, indoor surfaces and ventilation air distribution systems to environmental tobacco
smoke (ETS). 
 LEED-CS 150 Second has prohibited smoking inside the building, and prohibited smoking on the property from within 25 feet of entries,
outdoor air intakes and operable windows. 
 LEED-CI Tenants attempting LEED-CI at 150 Second will automatically comply with this prerequisite,
through LEED-CI IEQp2: Environmental Tobacco Smoke Control, 

  
 



 
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due to the building’s no smoking policy. Tenants are prohibited from smoking within the building and have ben provided designated smoking areas which are at least 25 feet away from building
entries, outdoor air intakes and operable windows. Signage indicating that smoking is not allowed within 25 feet of the all entrances will be provided for the entire building. 

IEQc1: Outdoor Air Delivery Monitoring 
 Intent To
provide capacity for ventilation system monitoring to help promote occupant comfort and well-being. 
 LEED-CS 150 Second has installed a permanent
monitoring system to ensure that ventilation systems in all public spaces maintain design minimum requirements. This has been accomplished through the incorporation of CO2 monitoring devices and outdoor airflow measurement devices within the base
building. Furthermore, the installed system in the base building is capable of being expanded to provide CO2 monitoring within the tenant spaces. 

LEED-CI Tenants attempting LEED-CI at 150 Second can achieve one point for installing permanent ventilation monitoring systems within their tenant
space, through IEQc1: Outdoor Air Delivery Monitoring. 
 IEQc2: Increased Ventilation 

Intent To provide additional outdoor air ventilation to improve indoor air quality (IAQ) and promote occupant comfort, well-being and productivity. 

LEED-CS 150 Second has increased breathing zone outdoor air ventilation rates to all occupied spaces by at least 30% above the minimum rates required
by ASHRAE 62.1-2007 for the base building. Furthermore, the base building systems have provided tenants with the ability to achieve LEED-CI, IEQc2: Increased Ventilation within their space by providing increased ventilation for each zone. 

LEED-CI Tenants attempting LEED-CI at 150 Second can achieve one point, through LEED-CI IEQc2: Increased Ventilation, by providing additional air
ventilation through appropriate mechanical or natural ventilation design strategies. The base building has provided the ability to easily facilitate increased ventilation within the tenant space. 

  
 



 
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 IEQc3: Construction Indoor Air Quality Management Plan – During Construction 

(LEED-CI, IEQc3.1) 
 Intent To reduce indoor air
quality (IAQ) problems resulting from construction or renovation and promote the comfort and well-being of construction workers and building occupants. 

LEED-CS 150 Second has developed and implemented an IAQ management plan for the construction and pre-occupancy phases for the base building. As a
result, the base building has provided a healthy indoor environment for tenants as they commence occupancy in their space. Measures taken as part of the IAQ plan included enclosed space ventilation, protection of absorption materials from moisture
damage, replacement of filters prior to occupancy, among other requirements from the Sheet Metal and Air Conditioning National Contractors Association (SMACNA) guidelines. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point, through LEED-CI IEQc3.1: Construction IAQ Management Plan – During
Construction, for developing and implementing their own IAQ management plan for the construction and preoccupancy phases of the tenant space. 
 IEQc3.2:
Construction Indoor Air Quality Management Plan – Before Occupancy 
 Intent To reduce indoor air quality (IAQ) problems resulting from
construction or renovation to promote the comfort and well-being of construction workers and building occupants. 
 LEED-CS There is no related
LEED-CD credit. 
 LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by performing a building flush-out or air testing the
tenant space to ensure a healthy indoor environment. 
 IEQc4.1: Low-Emitting Materials-Adhesives & Sealants 

Intent To reduce the quantity of indoor air contaminants that are odorous, irritating and/or harmful to the comfort and well-being of installers and
occupants. 
 LEED-CS 150 Second has complied with the applicable volatile organic compound (VOC) requirements for all adhesives and sealants
installed within the weather barrier for the base building. As a result, the base building has provided a healthy indoor environment for tenants as they commence occupancy in their space. 

  
 



 
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 LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by ensuring that all adhesives
and sealants installed within the tenant space comply with the applicable VOC limits. 
 IEQc4.2: Low-Emitting Materials – Paints and Coatings

 Intent To reduce the quantity of indoor air contaminants that are odorous, irritating and/or harmful to the comfort and well-being of
installers and occupants. 
 LEED-CS 150 Second has complied with the applicable volatile organic compound (VOC) requirements for all paints and
coatings installed within the weather barrier for the base building. As a result, the base building has provided a healthy indoor environment for tenants as they commence occupancy in their space. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by ensuring that all paints and coatings installed within the tenant space
comply with the applicable VOC limits. 
 IEQc4.3: Low-Emitting Materials – Flooring Systems 

Intent To reduce the quantity of indoor air contaminants that are odorous, irritating and/or harmful to the comfort and well-being of installers and
occupants. 
 LEED-CS 150 Second has complied with the applicable standards for all flooring systems installed within the weather barrier for the
base building. As a result, the base building has provided a healthy indoor environment for tenants as they commence occupancy for their space. 
 LEED-CI
Tenants attempting LEED-CI at 150 Second may achieve one point by ensuring that all flooring systems installed within the tenant space comply with the applicable standards. 

IEQc4.4: Low-Emitting Materials – Composite Wood and Agrifiber Product 

Intent To reduce the quantity of indoor air contaminant that are odorous, irritating and/ or harmful to the comfort and well-being of installers and
occupants. 

  
 



 
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 LEED-CS All composite wood and agrifiber products used on the interior of 150 Second have contained no
added urea-formaldehyde resins for the base building. As a result, the base building has provided a healthy indoor environment for tenants as they commence occupancy in their space. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by ensuring that all composite wood and agrifiber products installed within
tenant space contain no added urea-formaldehyde resins. 
 IEQc4.5: Low-Emitting Materials – Systems Furniture and Seating (LEED-CI Only) 

Intent To reduce the quantity of indoor air contaminants that are odorous, irritating and/or harmful to the comfort and well-being of installers and
occupants. 
 LEED-CS No related LEED-CS credit. 

LEED CI Tenants attempting LEED-CI at 150 Second may achieve one point by ensuring that all systems furniture and seating installed within the tenant
space comply with the applicable standards. 
 IEQc5: Indoor Chemical and Pollutant Source Control 

Intent To minimize building occupant exposure to potentially hazardous particulates and chemical pollutants. 

LEED-CS 150 Second has complied with the applicable measures for indoor chemical and pollutant source control for the base building. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by minimizing and controlling the entry of pollutants into the tenant space
through the employment of all applicable requirements of LEED-CI IEQc5: Indoor Chemical and Pollutant Source Control. The base building has provided a permanent entryway system at all major entrances, sufficient exhaust and sealing of housekeeping
and janitorial rooms, MERV-13 filtration on air handling units and closed containment systems for all hazardous liquid wastes. In addition, tenants are required to provide a 10-foot long entryway system for all main entrances. 

  
 



 
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 IEQc6.1: Controllability of Systems – Lighting 

Intent To provide a high level of lighting system control by individual occupants or groups in multi-occupant spaces (e.g., classrooms and conference
areas) and promote their productivity, comfort and well-being. 
 LEED-CS There is no related LEED-CS credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by providing individual lighting control for at least 90% of occupants of the
tenant space and for all multi-occupant spaces. 
 IEQc6: Controllability of Systems – Thermal Comfort (LEED-CI, IEQc6.2) 

Intent To provide a high level of thermal comfort control by individual occupants or groups in multi-occupant spaces (e.g. classrooms and conference
areas) and promote their productivity, comfort and well-being. 
 LEED-CS 150 Second did not pursue this credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by providing individual thermal comfort controls for at least 50% of occupants
of the tenant space and for all multi-occupant spaces. 
 IEQc7: Thermal Comfort – Design (LEED-CI, IEQc7.1) 

Intent To provide a comfortable thermal environment that promotes occupant productivity and well-being. 

LEED-CS 150 Second has designed and installed the HVAC system and building envelope to meet the requirements of ASHRAE-55-2004 for the base building.
ASHRAE-55 requires the regulation of temperature and humidity levels within the building based on climate zone. The base building has provided the ability for tenants to comply with the requirements of ASHRAE 55-2004 during build-out of their tenant
space. 
 LEED-CI Tenants attempting LEED CI at 150 Second will achieve one point by demonstrating that the HVAC system meets the requirements of
ASHRAE-55-2004. 
  

  
 



 
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 IEQc7.2: Thermal Comfort – Verification (LEED-CI Only) 

Intent To provide for the assessment of building occupants’ comfort over time. 

LEED-CS There is no related LEED-CS credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second can achieve one point by meeting the following requirements: 

 

	•	 	Achieving IEQc7.1 

  

	•	 	Providing a permanent monitoring system and process for corrective action to ensure that building performance meets the desired comfort criteria. 


 

	•	 	Conduct a thermal comfort survey of tenant space occupants within 6-18 months after occupancy. 

 IEQc8.1:
Daylight and Views – Daylight 
 Intent To provide occupants with a connection between indoor spaces and the outdoors through the
introduction of daylight and views into the regularly occupied areas of the building. 
 LEED-CS 150 Second did not pursue this credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second will achieve one point by providing sufficient daylight to at least 75% of regularly spaces. To do so
tenants must be sure that their fit-out does not compromise the daylight provided by the base building, new simulations may need to be run. 
 IEQc8.2:
Daylight and Views – Views 
 Intent To provide occupants with a connection between indoor spaces and the outdoors through the introduction
of daylight and views into the regularly occupied areas of the building. 
 LEED-CS 150 Second has achieved direct views to the outdoor environment
through vision glazing for 91% of regularly occupied areas. The calculation of views for tenant spaces was done using a feasible tenant layout per the default occupancy counts. 

  
 



 
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 LEED-CI Tenants attempting LEED-CI at 150 Second will achieve one point by providing direct views to
the outdoor environment through vision glazing for at least 90% of regularly occupied areas. To do so tenants must be sure that their fit-out does not compromise the views provided by the base building. Tenants should consider using an open plan,
desk partitions less than 42” in height in areas where views to the outside area possible, and glass partitions around common meeting areas. 

Innovation in Design (ID) 
 IDc1: Innovation in Design

 Intent To provide design teams and projects the opportunity to be awarded points for exceptional performance above the requirements set by LEED
and to develop innovation ideas in green building categories not specifically addressed by LEED. 
 LEED-CS 150 Second has four points in the LEED ID
category: 
  

	•	 	The base building has achieved exemplary performance under SSc4.1. 

  

	•	 	The base building has achieved exemplary performance under MRc2. 

  

	•	 	The base building has achieved exemplary performance under SSc2. 

  

	•	 	The base building participated in Pilot Credit 12 Reduced Automobile Dependence. 

 LEED-CI Tenants
attempting LEED-CI at 150 Second are encouraged to achieve all four ID credits through creative design and management of their built-out space. 
 IDc2:
LEED Accredited Professional 
 Intent To support and encourage the design integration required by LEED green buildings and to streamline the
application and certification process. 
 LEED-CS 150 Second has accomplished this through the participation of many LEED Accredited Professionals on
the design team and a sustainability consultant. The use of a LEED-AP as a responsible member of the design team for the base building and any tenant improvements will help ensure that the design and material specifications for the project will
properly address the established sustainable design criteria for the project. 
 LEED-CI Tenants attempting LEED-CI at 150 Second are encouraged to
include at least one principle participant on the project team, who has successfully completed the LEED Accredited Professional exam. Tenants can achieve one point for LEED-CI. 

  
 



 
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 Appendix A: Reference Material 

Tenants should refer to the link below for a reference guide for the LEED 2009 for Commercial Interiors (LEED-CI) Rating System.
http://www.usgbc.org/ShowFile.aspx?DocumentID=5543 
 For reference, tenants should see to the LEED-CI 2009 Scorecard below. 

 
 



 

  
 



 
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 EXHIBIT I TO LEASE 

PARKING PLAN 

  
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 EXHIBIT J TO LEASE 

RULES AND REGULATIONS 
 Tenant (and
tenant employees and contractors) shall faithfully observe and comply with the following Rules & Regulations: 
  

	 	1.	The sidewalks, entrances, service elevator lobby, corridors, stairwells, and fire exits of the building shall not be encumbered by any tenant or its agents, employees, licensees or guests or shall be used for
tenant’s premises provided that the stairwells may be so used. 

  

	 	2.	All deliveries to and removals from the building of furniture, equipment and supplies shall be by way of the loading dock – a platform (delivery entrance) located at the ground level of the building and accessible
from the street and then only during such hours as may be prescribed by the owner’s representative (Monday through Friday, 7AM – 5PM). During such hours there shall be no separate charge to tenant for the normal use of the loading dock or
freight elevator. Tenant shall be responsible for any loss, cost or damage suffered or incurred as a result of or arising from deliveries and/or removals after such hours. 


 

	 	3.	The loading dock and service elevator are for pick ups and deliveries only. Due to limited space at the loading dock, there is a vehicle parking limit of thirty (30) minutes, provided other deliveries are waiting,
unless special arrangements are made with the Property Management Office. Persons using service elevators will sign in at the security desk in the main lobby and be issued a floor pass. Each tenant will supply a list of authorized employees that
require access to the freight elevators. 

  

	 	4.	All incoming and outgoing shipments must be moved directly, by the delivery or pick up agent from the delivery entrance: such shipments will not be held at the delivery entrance. Building operating personnel are not
authorized to sign receipt for shipments to or from the building. 

  

	 	5.	Furniture, equipment and supplies and other packaged materials and items requiring the use of a hand truck, pallet truck or other type of wheeled transport, shall be moved only upon the service elevator.


  

	 	6.	All large deliveries, pick ups, moves and removal of demolition materials must be transported on the service elevator after hours, with prior approval of the owner’s representative and at the expense
of the tenant. The removal of demolition material and the delivery of sheet rock will require the smoke detectors in the freight elevators to be disabled. 


  
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	 	7.	No hand truck, pallet truck or other type of wheeled transport shall be used in the lobbies, corridors or elevators of the building other than in the loading dock corridor to and including the freight elevator.


  

	 	8.	The owner’s representative reserves the right to inspect all items to be brought into the building and to exclude from the building all items which violate any provision of the rules and regulations or which may,
in the reasonable judgment of the owner’s representative, constitute a hazard or danger to the building, its equipment or occupants. 

  

	 	9.	Any damage to the building or any part thereof caused by the moving in our out of the building of furniture, equipment, supplies, or other items, shall be repaired by the owner’s representative at the expense of
the tenant responsible. 

  

	 	10.	Tenant shall notify the property management office when safes or other heavy equipment, except in the ordinary course of tenant’s business operations in accordance with its permitted use, are to be taken in or out
of the building, and such moving shall only be done after written permission is obtained from the property management office on such conditions, as the property management office shall require. Additional costs related to the installation of such
equipment, shall, as for elevator use or window removal, will be borne by tenant. 

  

	 	11.	All construction and demolition work requires a written request to be approved by the property management office who will act reasonably in connection therewith. Tenant and tenant’s contractor will be required to
follow the 150 Second Street Tenant Improvement Rules and Regulations that is available upon request at the property management office. Upon completion of approved work, if applicable, Tenant must provide “As-Built” drawings in both CAD
and black line form to the owner’s representative. 

  

	 	12.	Access to the area above the ceiling must be scheduled and approved by the property management office. All ceiling tiles must be back in place by the end of the working day. 


 

	 	13.	The property management office reserves the right to control and operate the public portions of the building and the public facilities, as well as the facilities furnished for the common use of the tenants, in such
manner as they deem best for the benefit of the tenants. 

  

	 	14.	The property management office reserves the right to exclude from the building, during non-business hours, all persons who do not present a valid building access photo id card that are not otherwise escorted by a Tenant
representative. 


  
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	 	15.	The property management office must be given advance written notification of any after-hour functions requiring access via loading dock or building services. Tenant shall reimburse the owner’s representative for
any third party out of pocket costs incurred in connection with these services. 

  

	 	16.	No additional locks or bolts of any kind shall be placed upon any of the doors in any tenant’s premises and no lock on any door therein shall be changed or altered in any respect without property management
approval. In the case where tenant has equipment in the MEP rooms, card readers are to be installed by tenant, and a room access list provided to building management. 


 

	 	17.	No acids, vapors, or other materials shall be discharged into non-designated waste lines, vents or flues of the building. The water wash closets and other plumbing fixtures in or serving any tenant’s premises (not
specifically designed for this purpose) shall not be used for any purpose other than that for which they were designed or constructed, and no sweeping shall be deposited therein. The property management office shall repair any damage resulting to
the same from misuse by a tenant, at the expense of the tenant. 

  

	 	18.	If a tenant’s premises becomes infested with vermin, such tenant, at its sole cost and expense, unless it is clearly determined that the same has been caused entirely by others, shall cause it premises to be
exterminated by such exterminators as shall be approved by the property management office at such times and to such extent as the property management office deems necessary. 


 

	 	19.	No part of the tenant’s premises shall be occupied at any time as sleeping quarters and no part of the building shall be used for gambling or for any immoral or unlawful purposes or practices. No intoxicating
liquor shall be sold in any part of the building unless allowed by the lease agreement. 

  

	 	20.	No animals or birds, bicycles, skate boards, in-line skater or other vehicles shall be allowed in the corridors, lobbies, elevators, sidewalks, walkways, gardens, or elsewhere in or around the building (provided that
animals related to vivarium usage may be housed in the vivarium in tenant’s premises and transported in the freight elevator). Bicycle storage is available at the designated areas in the garage and at the front entrance by the canopy.


  

	 	21.	Canvassing, soliciting or peddling in the building is prohibited and each tenant shall cooperate to prevent the same. 

  

	 	22.	A building directory with the names of the tenants will be provided and maintained by the property management office. The property management office at the tenant’s expense will make changes in the directory,
within a reasonable time period after written notice from the tenant. 


  
 J-3 









	 	23.	Tenants may be requested to assign from their employees, personnel to perform specific tasks required by the building’s emergency evacuation plan. Person so assigned shall be made available from time to time for
instructions by the building life safety director. 

  

	 	24.	Access to building tele/com centers and closets will be provided by building security only. Anyone requesting access must have a valid id from the telecommunication company that employs them or be listed on the approved
access list that is maintained at the property management office. Tenant may elect to install a card reader and provide documentation of appropriate personnel training to allow authorization for room access. 


 

	 	25.	Building maintenance will provide access to the building electric closets. Tenants will be required to notify the property management office by electronic mail should a vendor require access. All tenant vendors must
have a valid id from the company that employees them or be listed on the approved access list that is maintained at the property management office. Tenant may elect to install a card reader and provide documentation of appropriate personnel training
to allow authorization for room access. 

  

	 	26.	Portable electric heaters, fans or desktop heating appliances (coffee cup warmers) are not allowed inside any tenant spaces or common areas within the building, unless approved by the property management office.


  

	 	27.	Prior written approval, which shall be at the sole discretion of the property management office, must be obtained for installation of any window shades, blinds, drapes or any other window treatment of any kind; provided
however, the foregoing restriction shall not apply to any of such items that are installed as part of Tenant’s Work in conformity with the Plans. 

  

	 	28.	Plumbing, fixtures and appliances shall be used only for the purpose for which constructed, no other unsuitable material shall be placed therein. 


 

	 	29.	Owner and property management office shall have the right to prescribe the weight and position of heavy equipment or objects, which may overstress any portion of the floors of the premises. All damage done to the
building by the improper placing of such heavy items will be repaired at the sole expense of the tenant. 

  

	 	30.	No nails, hooks or screws shall be driven into or inserted in any part of the building except as approved by the property management office, permitted by tenant’s lease, or as reasonably necessary to permit tenant
to hang pictures and other wall decorations or wall hangings (e.g., whiteboards, corkboards, signs, shelves, etc.) within the premises. 


  
 J-4 









	 	31.	Tenant shall comply with all requirements necessary for the security of the premises, including the use or property removal passes for the removal of office equipment/packages, and use of security control cards for
access to the building at all times. 

  

	 	32.	Smoking is not permitted in the 150 Second Street common areas including exterior entrances, vestibules, corridors, restrooms, stairwells and parking garage. Additionally, smoking is not allowed within 25 feet of the
front of the entrance of the building as well as the loading dock entrance. Tenant must comply with requests by the owner’s representative concerning informing their employees of items of importance to the owner. 


 

	 	33.	All doors opening to public corridors shall be kept closed at all times except for normal ingress and egress to the premises, unless electrical holdbacks have been installed. 


 

	 	34.	Owner reserves the right to close and keep locked all entrance and exit doors during hours when the building is closed. Access to the building may be refused unless person seeking access has proper identification or has
previously arranged a pass for access to the building. The owner and its representative shall in no case be liable for damages for any error with regard to the admission to or exclusion from the building of any person. In case of invasion, mob,
riot, public excitement or other commotion, owner reserves the right to prevent access to the building during the continuance of it by any means it deems appropriate for the safety and protection of life and property. 


 

	 	35.	No furniture, freight, equipment or other bulky matter will be brought into or removed from the building or carried up or down in elevators, except upon prior notice to the property management office and in such manner,
in such specific elevator, and between such hours as shall be reasonably designated by the owner; provided however , (i) the foregoing restrictions shall not apply to items brought into the building in connection with Tenant’s Work,
or (ii) for items delivered to the Premises on a recurring basis, such approval need only be obtained from Landlord once. Tenant shall provide the property management office with reasonable prior notice of the need to utilize the elevator for
any such purpose, so as to provide owner with a reasonable period to schedule such use and to install such padding or take such other actions or prescribe such procedures as are appropriate to protect against damage to the elevators or other parts
of the building. 

  

	 	36.	Tenant shall not disturb, solicit or canvass any occupant of the building and shall cooperate with the owner or owner’s agent to prevent it. 


 

	 	37.	The toilet rooms, urinals, wash bowls and other apparatus shall not be used for any purpose other than that for which they were constructed and no foreign substance of any kind whatsoever shall be thrown therein.



  
 J-5 









	 	38.	Tenant shall not use any method of heating or air conditioning other than that which is supplied by the owner without the prior written consent of the owner. 


 

	 	39.	Cooking shall not be permitted or done by any tenant on the premises, nor shall the premises be used for the storage of merchandise for lodging of for any improper objectionable or immoral purposes. Notwithstanding the
foregoing, laboratory approved equipment and microwave ovens and/or small toaster ovens may be used on the premises for heating food and brewing coffee, tea, hot chocolate and similar beverages, provided that such use is in accordance with
applicable federal, state and city laws, codes, ordinances, rules and regulations, and does not cause odors which are objectionable to owner and other tenants. 

  

	 	40.	Owner will approve where and how telephone wires are to be introduced to the premises. No boring or cutting for wires shall be allowed without the consent of the owner. The location of telephone, call boxes and other
office equipment affixed to the premises shall be subject to the approval of the owner. 

  

	 	41.	Tenant, it’s employees and agents shall not loiter in the entrances or corridors, nor in any way obstruct the sidewalks, lobby, halls, stairwells or elevators and shall use the same only as a means of ingress and
egress for the premises. 

  

	 	42.	Tenant shall store all trash and garbage within the interior of the premises. No material shall be placed in the trash boxes or receptacles if material is of such nature that it may not be disposed of in the ordinary
and customary manner of removing and disposing of trash and garbage in the City of Cambridge without violation of any law or ordinance governing such disposal. All trash, garbage and refuse disposal shall be made only through entryways and elevators
provided for such purposes at such times, as owner shall designate. Building has a compactor that is maintained and operated by building management. 

  

	 	43.	Tenant shall assume any and all responsibility for protecting the premises form theft, robbery and pilferage, which includes keeping doors locked and other means of entry to the premises closed, when the premises are
not occupied. 

  

	 	44.	Owner may waive any one or more of these Rules and Regulations for the benefit of any particular tenant or tenants. This shall not prevent the owner from thereafter enforcing any such Rules and Regulations against any
or all tenants of the building. 


  
 J-6 









	 	45.	No awnings or other projects shall be attached to the outside walls of the building without the prior written consent of the owner. No curtains, blinds, shades or screens shall be attached to or hung in, or used in
connection with any window or door of the premises without prior written consent of the owner. All electrical ceiling fixtures hung in offices or spaces along the perimeter of the building must be fluorescent and/or of a quality, type, design and
bulb color approved by the owner. 

  

	 	46.	Food vendors shall be allowed in the 150 Second Street building upon receipt of a written request from the tenant. The food vendor shall service only the tenants that have a written request on file in the property
management office. Under no circumstances shall the food vendor display their products in a public or common area including corridors and elevator lobbies. Any failure to comply with this rule shall result in the immediate permanent withdrawal of
the vendor from 150 Second Street. 

  

	 	47.	Tenant shall comply with any non smoking ordinances adopted by any applicable governmental authority. In addition, owner reserves the right to designate in owner’s sole discretion, the only outside areas of the
premises where smoking shall be permitted. 

  

	 	48.	Owner and its agent have the right to evacuate 150 Second Street in the event of an emergency or catastrophe. 

  

	 	49.	Provided such changes are not in conflict with the terms of this Lease and that Landlord provides prior written notice of such change, Owner and its agent reserves the right at any time to change or rescind any one or
more of these Rule and Regulations or to make such other further reasonable Rules and Regulations as in owner’s judgment may from time to time be necessary for the management, safety, care and cleanliness of the premises and building, and for
the preservation of good order therein, as well as for the convenience of other occupants and tenants. Owner shall not be responsible to tenant or to any other person for the non-observance of the Rules and Regulations and tenant shall agree to
abide by these rules as a condition of its occupancy of the premises. 


  
 J-7 








 FIRST AMENDMENT TO LEASE 

THIS FIRST AMENDMENT TO LEASE (“Amendment”) dated as of November 15, 2013 by and between 150 Second Street, LLC, a
Delaware limited liability company (“Landlord”), and Bluebird Bio, Inc., a Delaware corporation (“Tenant”). 

Preliminary Statement 

Landlord and Tenant entered into the Lease, dated as of June 3, 2013, regarding the premises containing approximately 43,586 rentable
square feet comprising the entire third floor of the building located at 150 Second Street, Cambridge, Massachusetts (“Lease”). 

Landlord and Tenant wish to amend the Lease to acknowledge and memorialize the following: 

 

	 	(A)	Tenant has installed a gas pressure booster to support Tenant’s emergency generator located on the roof of the Building. Tenant has also installed an uninterruptible power supply device to support Tenant’s
generator in the event of a power failure. Tenant has requested permission to connect Tenant’s gas pressure booster to the base building generator as a secondary source of power supply in the event of a power failure. Landlord is willing to
allow such connection upon the terms and conditions set forth in this Amendment. 

  

	 	(B)	Tenant has requested permission to install Tenant’s Dry Cooler units in the screened-in penthouse area of the Building. Landlord is willing to allow such installation upon the terms and conditions set forth in this
Amendment. 

  

	 	(C)	Tenant wishes to cause a vivarium to be installed in Tenant’s Shared Space located on the first floor of the Building, and not within the Premises as originally intended. Landlord is willing to approve such request
upon the terms and conditions set forth in this Amendment. 

 NOW, THEREFORE, in consideration of the premises and the mutual
agreements contained herein and in the Lease, Landlord and Tenant hereby agree as follows: 
 1. Base Building Generator. Tenant
acknowledges that Landlord has no obligation under the Lease to provide an emergency generator or emergency back-up power to Tenant. Notwithstanding the foregoing, Landlord hereby agrees to allow Tenant to cause Tenant’s gas pressure booster to
be connected to Landlord’s base building standby emergency generator panel subject to the applicable requirements set forth in the Lease and the following terms and conditions: 

 

	 	(a)	All installation and connection work and use of the base building generator shall be performed at Tenant’s cost and in compliance with all applicable Legal Requirements. 


 

	 	(b)	Tenant acknowledges that neither Landlord nor any consultant, employee or agent of Landlord has made any representation or warranty regarding the specifications of the base building generator or the suitability or
sufficiency thereof for Tenant’s use. 









	 	(c)	Tenant hereby waives any Claims against Landlord arising from any interruption of service or failure of the base building generator to operate properly from any cause whatsoever. No such interruption or failure shall
result in eviction or constructive eviction of Tenant, termination of this Lease or the abatement of Rent. Tenant hereby indemnifies Landlord from and against any and all Claims arising in connection Tenant’s use of the base building generator
as a supplemental power source for Tenant’s purposes unless caused solely by Landlord’s negligence or willful misconduct. 

  

	 	(d)	If at any time during the Term, Landlord reasonably determines, that Tenant’s connection to and use of the base building generator violates any applicable Legal Requirement or insurance requirement, voids any
warranty or otherwise adversely affects the Building or any other tenant, then Tenant shall, upon reasonable notice from Landlord attempt to correct such violation or issue. If Tenant is unable to do so, Tenant shall discontinue use of the base
building generator and shall restore the equipment or connections to the original condition or configuration reasonable wear and tear excepted. 

  

	 	(e)	No further alterations or connections to the base building generator shall be made or permitted without Landlord’s consent. 

  

	 	(f)	Once installed, the gas pressure booster shall not be removed by Tenant at any time during the Term. Upon the expiration or earlier termination of the Lease, Tenant’s ownership interest in the gas pressure booster
shall transfer to Landlord without charge, and Tenant agrees that it will not remove the gas pressure booster from the Premises. 


2. Dry Cooler Units. Tenant may cause its dry cooler units and any appurtenant equipment for the cooling of Tenant’s Liebert units
(collectively, “Dry Cooler Units”) to be installed within the screened-in penthouse area of the Building in the location shown on the sketch plan attached hereto as Exhibit A. The installation and use of the Dry Cooler Units are
subject to the requirements set forth in the Lease and the following terms and conditions: 
  

	 	(a)	Notwithstanding any provision to the contrary contained in the Lease, Tenant shall remove the Dry Cooler Units upon the expiration or earlier termination of the Lease, restore the applicable area and repair any damage
related to the removal of such equipment at Tenant’s cost. 

  

	 	(b)	The Landlord shall retain the right to cause the Dry Cooler Units to be relocated to another location within the property reasonably acceptable to Tenant at the Landlord’s cost provided that such relocation would
not materially adversely affect the performance of the Dry Cooler Units. 


  
 168 









	 	(c)	Tenant shall not modify the initial tenant improvements or propose any future alterations that would use more air handling capacity than 56,350 CFM. 


3. Vivarium. Tenant may cause a vivarium to be installed and used in Tenant’s allocated Shared Space located on the first floor of
the Building near the loading dock, as shown on the plan attached to this Amendment as Exhibit B, subject to the applicable provisions of the Lease and the following terms and conditions: 

 

	 	(a)	No construction work shall commence until Landlord approve the final plans and specifications pertaining to the work; 

  

	 	(b)	Tenant’s installation and use of the vivarium shall comply with all applicable Legal Requirements and shall not, in Landlord’s reasonable judgment, adversely affect the use and enjoyment of the other occupants
of the Building; 

  

	 	(c)	Landlord shall not have any obligation to make any improvements or alterations to the Shared Space to prepare such space for Tenant’s proposed use; 


 

	 	(d)	Tenant, at its sole expense, shall keep Tenant’s Shared Space clean and in good condition; 

  

	 	(e)	Landlord shall not be required to provide any services to the Shared Space; and 

  

	 	(f)	Upon the expiration or earlier termination of the Lease, Tenant shall restore the applicable area and repair any damage related to the removal of the vivarium. 


4. Ratification. Except only as expressly amended hereby, the Lease shall continue in full force and effect as heretofore. This
Amendment sets forth the entire agreement of the parties with respect to the subject matter as of the date hereof and no prior agreement, letters, representations, warranties, promises or understandings pertaining to any such matters shall be
effective for any such purpose. 
 5. Defined Terms. All capitalized terms in this Amendment shall have the same meaning as in the
Lease, unless otherwise defined herein: 
 6. Bind and Inure. This document shall become effective and binding only upon the
execution and delivery of this Amendment by Landlord and Tenant. 
 7. Counterparts. This Amendment may be executed in any number of
counterparts, provided each of the parties hereto executes at least one counterpart; each such counterpart hereof shall be deemed to be an original instrument, but all such counterparts together shall constitute but one agreement. This Amendment may
be executed and delivered by facsimile or other electronic transmission, and such signatures shall have the same force and effect as originals. 

  
 169 








 WITNESS the execution hereof as an instrument under seal as of the day first above written. 

 

			
	LANDLORD:
	
	 150 SECOND STREET, LLC,
 a
Delaware limited liability company

		
	By:	 	 /s/ Shawn Hurley

		 	Shawn Hurley, Manager
		
	By:	 	 /s/ Mats Johannson

		 	Mats Johansson, Manager
	
	TENANT:
	
	 BLUEBIRD BIO, INC.,
 a
Delaware corporation

	
	 By: /s/ Jeffrey T. Walsh
 Name:
Jeffrey T. Walsh
 Title: COO




  
 170 








 EXHIBIT A 

Plan Showing Location of Dry Cooler Units 







 



 







 EXHIBIT B 

Plan Showing Location of Vivariumpgs 







 



 







 



 







 TENANT ESTOPPEL CERTIFICATE 

 

			
	 150 SECOND STREET, LLC
 c/o Skanska USA
Commercial Development
 253 Summer Street
 Boston, MA 02110

Attention: Shawn Hurley
	  	 ARE-MA Region No. 50, LLC
 385 E. Colorado
Boulevard, Suite 299
 Pasadena, CA 91101
 Attention: Corporate
Secretary


 Ladies and Gentlemen: 
 By lease
dated as of June 3, 2013 (the “Lease”), the undersigned (“Tenant”) has leased from 150 SECOND STREET, LLC, a Delaware limited liability company, or its predecessors in interest
(“Landlord”) the premises located at 150 Second Street, Cambridge,. Massachusetts which is more particularly described in the Lease. Landlord, as owner of the property (the “Property”) of which the leased premises
are a part, intends to sell the Property to ARE-MA Region No. 50, LLC, a Delaware limited liability company (“Purchaser”) who, as a condition to the purchase of the Property, has required this tenant estoppel
certificate. 
 In consideration of Purchaser’s agreement to . purchase the Property and for other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, Tenant agrees and certifies to Landlord and to Purchaser as of the date hereof as follows: 

1. Attached hereto as Exhibit 1 is a true, correct and complete copy of the Lease, including the following amendments,
modifications, supplements, guarantees and restatements thereof, which together represent all of the amendments, modifications, supplements, guarantees and restatements thereof: First Amendment to Lease of even date herewith (If none, please
state “None.”) The Lease constitutes the complete agreement between Landlord and Tenant for the leased premises and the Property, except as modified by the Lease amendments noted above (if any), has not been modified, altered or amended.

 2. The leased premises contain 43,586 rentable square feet. Tenant is entitled to use 1,646 square feet of Storage Space located in the
basement of the Building. Tenant is entitled to use Tenant’s Share of 4,847 square feet of Shared Space located on the first floor, basement and penthouse of the Building. Tenant’s Share is 35.38%. 

3. The leased premises and possession thereof are accepted; the Lease is in full force and effect. The Lease Commencement Date will be
January 1, 2014 and the Base Term expires on the last day of the 108 month after the Lease Commencement Date occurs. 
 4. As of the
date hereof, Tenant claims no present charge, lien or claim of offset against rent after the Rent Commencement Date. 
 5. The Rent
Commencement Date is anticipated to occur on July 1, 2014. Rent will not be paid more than one month in advance. As of the Rent Commencement Date, Base Rent will be $208,849.58 per month and is due on the first of each month. A security deposit
in the amount of $1,253,097.48 has been paid to Landlord in the form of a letter of credit (a copy of which is attached). Rent in respect of Tenant’s Share of the Storage Space will be $2,469.00 per month based on $18.00 per square foot. 







 6. There are no existing defaults by reason of any act or omission of the Landlord except as
follows: NONE. (If none, please state “None.”) 
 7. As of the date of this Certificate, to the best of
Tenant’s knowledge, Landlord has performed all obligations required of Landlord pursuant to the Lease; no offsets, counterclaims, or defenses of Tenant under the Lease exist against Landlord; and no events have occurred that, with the passage
of time or the giving of notice, would constitute a basis for offsets, counterclaims, or defenses against Landlord, except as follows: NONE. (If none, please state “None.”) Landlord has no outstanding obligations under the Lease
(including tenant improvements or tenant improvement allowances), except as follows: Funding the balance of the Landlord’s Contribution. As of the date hereof, the unfunded amount of the Landlord’s Contribution is $4,365,127.54. 

8. Tenant has no option, right of first refusal or other right to purchase the Property or any portion thereof, or any interest therein
pursuant to the terms of the Lease or contained in any other document or agreement (written or oral) whatsoever. The only interest of Tenant in the Property is that of a tenant pursuant to the terms of the Lease. Tenant hereby waives any option,
right of first refusal or other right to purchase the Property or any portion thereof or interest therein that is contained in the Lease or any other document or agreement, if any. 

9. Tenant has not sublet or assigned the leased premises or the Lease or any portion thereof to any sublessee or assignee. The address for
notices to be sent to Tenant is as set forth in the Lease. 
 10. There is not pending or, to the knowledge of Tenant, threatened against or
contemplated by the Tenant, any petition in bankruptcy, whether voluntary or otherwise, any assignment for the benefit of creditors, or any petition seeking reorganization or arrangement under the federal bankruptcy laws or those of any state. 

11. Tenant has committed to the use of twenty eight (28) parking spaces in the garage and fifteen (15) surface parking spaces on the
parking lot at 29 Charles Street for the year commencing as of the Lease Commencement Date. 
 All capitalized terms used herein shall have
the same meaning as in the Lease, unless otherwise defined herein. 

  
 2 








 This certificate may be relied upon by Landlord, Purchaser, and their respective
successors and assigns. 
  

			
	TENANT:
	
	BLUEBIRD BIO, INC.
		
	By:	 	/s/ Jeffrey T. Walsh
	Name:  Jeffrey T. Walsh
	Title:  Chief Operating Officer
	Date:  November 15, 2013



  
 3 








 LEASE 

Between 
 150 SECOND
STREET, LLC 
 as Landlord, 

and 
 BLUEBIRD BIO, INC.

 as Tenant, 

For Premises located at: 

150 Second Street 

Cambridge, Massachusetts 







 TABLE OF CONTENTS 

 

					
	 ARTICLE 1 BASIC LEASE PROVISIONS; DEFINITIONS
	  	 	1	  
	 1.1 Basic Lease Provisions.
	  	 	1	  
	 1.2 Definitions.
	  	 	5	  
		
	 ARTICLE 2 PREMISES; APPURTENANT RIGHTS; RESERVATIONS
	  	 	8	  
	 2.1 Lease of Premises
	  	 	8	  
	 2.2 Appurtenant Rights
	  	 	9	  
	 2.3 Landlord Reservations.
	  	 	10	  
		
	 ARTICLE 3 DELIVERY OF PREMISES; ACCEPTANCE
	  	 	10	  
	 3.1 Delivery of Premises; Acceptance of Premises
	  	 	10	  
	 3.2 Acknowledgment of Lease Commencement Date.
	  	 	10	  
		
	 ARTICLE 4 RENT
	  	 	11	  
	 4.1 Base Rent
	  	 	11	  
	 4.2 Base Rent Abatement Period
	  	 	11	  
	 4.3 Additional Rent
	  	 	13	  
	 4.4 Intentionally Omitted
	  	 	14	  
	 4.5 Operating Expense Payments
	  	 	14	  
	 4.6 Taxes
	  	 	17	  
		
	 ARTICLE 5 CONDITION OF PREMISES; CONSTRUCTION
	  	 	18	  
	 5.1 Base Building Work
	  	 	18	  
	 5.2 Tenant’s Work
	  	 	18	  
	 5.3 Intentionally Deleted.
	  	 	20	  
	 5.4 Landlord’s Contribution
	  	 	20	  
		
	 ARTICLE 6 USE
	  	 	22	  
	 6.1 Use
	  	 	22	  
		
	 ARTICLE 7 PARKING
	  	 	22	  
	 7.1 Parking
	  	 	22	  
		
	 ARTICLE 8 UTILITIES; SERVICES
	  	 	24	  
	 8.1 Utilities; Services.
	  	 	24	  
	 8.2 Shafts and Risers.
	  	 	24	  
	 8.3 Rooftop Premises.
	  	 	25	  
	 8.4 Access.
	  	 	26	  
		
	 ARTICLE 9 ALTERATIONS
	  	 	26	  
	 9.1 Alterations and Tenant’s Property
	  	 	26	  
		
	 ARTICLE 10 REPAIRS AND MAINTENANCE
	  	 	28	  
	 10.1 Landlord’s Repairs
	  	 	28	  
	 10.2 Tenant’s Repairs
	  	 	29	  


  
 i 









					
	 ARTICLE 11 MECHANIC’S LIENS
	  	 	29	  
	 11.1 Mechanic’s Liens
	  	 	29	  
		
	 ARTICLE 12 INDEMNIFICATION
	  	 	30	  
	 12.1 Indemnification
	  	 	30	  
		
	 ARTICLE 13 INSURANCE
	  	 	30	  
	 13.1 Insurance
	  	 	30	  
		
	 ARTICLE 14 RESTORATION
	  	 	32	  
	 14.1 Restoration
	  	 	32	  
		
	 ARTICLE 15 CONDEMNATION
	  	 	33	  
	 15.1 Condemnation
	  	 	33	  
		
	 ARTICLE 16 EVENTS OF DEFAULT
	  	 	34	  
	 16.1 Events of Default
	  	 	34	  
	 16.2 Landlord’s Remedies.
	  	 	35	  
		
	 ARTICLE 17 ASSIGNMENT AND SUBLETTING
	  	 	37	  
	 17.1 General Prohibition
	  	 	37	  
	 17.2 Permitted Transfers
	  	 	37	  
	 17.3 Additional Conditions
	  	 	39	  
	 17.4 No Release of Tenant, Sharing of Excess Rents
	  	 	40	  
	 17.5 No Waiver
	  	 	40	  
	 17.6 Prior Conduct of Proposed Transferee
	  	 	40	  
		
	 ARTICLE 18 ESTOPPEL CERTIFICATE
	  	 	40	  
	 18.1 Estoppel Certificate
	  	 	40	  
		
	 ARTICLE 19 SUBORDINATION
	  	 	41	  
	 19.1 Subordination
	  	 	41	  
		
	 ARTICLE 20 SURRENDER
	  	 	41	  
	 20.1 Surrender
	  	 	41	  
		
	 ARTICLE 21 ENVIRONMENTAL REQUIREMENTS
	  	 	43	  
	 21.1 Prohibition/Compliance/Indemnity
	  	 	43	  
	 21.2 Business
	  	 	44	  
	 21.3 Tenant Representation and Warranty
	  	 	44	  
	 21.4 Testing
	  	 	44	  
	 21.5 Control Areas
	  	 	45	  
	 21.6 Intentionally Deleted
	  	 	45	  
	 21.7 Tenant’s Obligations
	  	 	45	  
	 21.8 Definitions
	  	 	45	  
		
	 ARTICLE 22 TENANT’S REMEDIES/LIMITATION OF LIABILITY
	  	 	46	  
	 22.1 Tenant’s Remedies/Limitation of Liability
	  	 	46	  
	 22.2 Limitation on Landlord’s Liability
	  	 	46	  


  
 ii 









					
	 ARTICLE 23 INSPECTION AND ACCESS
	  	 	47	  
	 23.1 Inspection and Access
	  	 	47	  
		
	 ARTICLE 24 SIGNAGE
	  	 	48	  
	 24.1 Signs; Exterior Appearance
	  	 	48	  
		
	 ARTICLE 25 HOLDING OVER
	  	 	48	  
	 25.1 Holding Over
	  	 	48	  
		
	 ARTICLE 26 WAIVER OF JURY TRIAL
	  	 	49	  
	 26.1 Waiver of Jury Trial
	  	 	49	  
		
	 ARTICLE 27 SECURITY DEPOSIT
	  	 	49	  
	 27.1 Security Deposit.
	  	 	49	  
		
	 ARTICLE 28 RIGHT TO EXTEND TERM
	  	 	50	  
	 28.1 Extension Rights
	  	 	50	  
	 28.2 Arbitration
	  	 	51	  
	 28.3 Rights Personal
	  	 	51	  
	 28.4 Exceptions
	  	 	52	  
	 28.5 No Extensions
	  	 	52	  
	 28.6 Termination
	  	 	52	  
		
	 ARTICLE 29 RIGHT OF FIRST OFFER
	  	 	52	  
	 29.1 Tenant’s Right of First Offer
	  	 	52	  
		
	 ARTICLE 30 MISCELLANEOUS
	  	 	53	  
	 30.1 Notices
	  	 	53	  
	 30.2 Joint and Several Liability
	  	 	53	  
	 30.3 Financial Information
	  	 	53	  
	 30.4 Recordation
	  	 	54	  
	 30.5 Interpretation
	  	 	54	  
	 30.6 Not Binding Until Executed
	  	 	54	  
	 30.7 Limitations on Interest
	  	 	54	  
	 30.8 Choice of Law
	  	 	54	  
	 30.9 Time
	  	 	54	  
	 30.10 OFAC
	  	 	55	  
	 30.11 Incorporation by Reference
	  	 	55	  
	 30.12 Entire Agreement
	  	 	55	  
	 30.13 No Accord and Satisfaction
	  	 	55	  
	 30.14 Hazardous Activities
	  	 	55	  
	 30.15 REIT/UBTI
	  	 	55	  
	 30.16 Quiet Enjoyment
	  	 	56	  
	 30.17 Prorations
	  	 	56	  
	 30.18 Rules and Regulations
	  	 	56	  
	 30.19 Security
	  	 	56	  


  
 iii 









					
	 30.20 Force Majeure
	  	 	57	  
	 30.21 Brokers
	  	 	57	  
	 30.22 Severability
	  	 	57	  


  
 iv 








 LEASE AGREEMENT 

THIS LEASE AGREEMENT (this “Lease”) is made as of the 3rd day of
June, 2013 (“Effective Date”), between 150 SECOND STREET, LLC, a Delaware limited liability company (“Landlord”), and BLUEBIRD BIO, INC., a Delaware corporation
(“Tenant”). 
 ARTICLE 1 

BASIC LEASE PROVISIONS; DEFINITIONS 
  

	 	1.1	Basic Lease Provisions. 

  

			
	Landlord:	  	150 Second Street, LLC, a Delaware limited liability company
		
	Landlord’s Address:	  	 c/o Skanska USA Commercial Development Inc.

253 Summer Street
 Boston, MA 02210

Attn: Charles Leatherbee

		
	Tenant:	  	Bluebird Bio, Inc., a Delaware corporation
		
	Tenant’s Original Address:	  	840 Memorial Drive Cambridge, MA 02139
		
	Address:	  	150 Second Street, Cambridge, Massachusetts
		
	Premises:	  	That portion of the Project known as Suite 300, containing 43,586 rentable square feet, comprising the entire third floor of the Building, including the Shared Space allocated to Tenant for Tenant’s mechanical, PH and lab
related storage located in the penthouse, first floor and lower level of the Building as shown on Exhibit A.
		
	Project:	  	The real property on which the building (the “Building”) in which the Premises are located at 150 Second Street, Cambridge, Massachusetts, together with all improvements thereon and appurtenances thereto
as described on Exhibit B.
		
	Base Rent:	  	$57.50 per rentable square foot of the Premises per annum with annual escalations as set forth in the following table:


  









													
	 Period
	  	Rate per RSF	 	  	Annual Base Rent	 	  	Monthly Base
Rent	 
	 Months 1(from Lease Commencement Date) through 12*
	  	$	57.50	  	  	$	2,506,195.00	  	  	$	208,849.58	  
	 Months 13 through 24*
	  	$	59.23	  	  	$	2,581,598.78	  	  	$	215,133.23	  
	 Months 25 through 36
	  	$	61.00	  	  	$	2,658,746.00	  	  	$	221,562.17	  
	 Months 37 through 48
	  	$	62.83	  	  	$	2,738,508.38	  	  	$	228,209.03	  
	 Months 49 through 60
	  	$	64.72	  	  	$	2,820,885.92	  	  	$	235,073.83	  
	 Months 61 through 72
	  	$	66.66	  	  	$	2,905,442.76	  	  	$	242,120.23	  
	 Months 73 through 84
	  	$	68.66	  	  	$	2,992,614.76	  	  	$	249,384.56	  
	 Months 85 through 96
	  	$	70.72	  	  	$	3,082,401.92	  	  	$	256,866.83	  
	 Months 97 through 108
	  	$	72.84	  	  	$	3,174,804.24	  	  	$	264,567.02	  

  

	*	Notwithstanding anything in this Section of the Lease to the contrary, Tenant shall be entitled to an abatement of Base Rent in the amount of $208,849.58 per month for six (6) consecutive full calendar months of
the Base Term beginning on the Lease Commencement Date, subject to the terms and conditions set forth in Section 4.2. 

  

			
	Rent Commencement Date:	  	The date following the Lease Commencement Date on which the full amount of the Rent Abatement has been fully applied to the Base Rent under this Lease subject to the terms and conditions set forth in Section 4.2.
		
	Rentable Area of Premises:	  	43,586 rentable square feet
		
	Rentable Area of Project:	  	123,210 square feet
		
	Tenant’s Share of Operating Expenses:	  	35.38%
		
	Lease Commencement Date:	  	The earlier of: (i) the Substantial Completion of Tenant’s Work (as set forth in Section 5.4) and Tenant’s occupancy of the Premises for purposes of conducting Tenant’s business operations; or (ii) January 1,
2014.


  
 2 









			
	Base Term:	  	Beginning on the Lease Commencement Date and ending on the last day of the one hundred eighth (108th) month thereafter.
		
	Extension Term:	  	One option for five (5) years as set forth in Section 28.
		
	Landlord’s Contribution:	  	Subject to Section 5.4 below, $150 per RSF of the Premises calculated to equal $6,537,900 based on Premises containing 43,586 RSF plus up to an additional $4,358.60 ($.10 per RSF) for out of pocket costs incurred in preparing the
initial test fit of the Premises.
		
	Permitted Use:	  	General office, research and development, laboratory and other related uses, including the use of a vivarium, consistent with the character of the Project and otherwise in compliance with the provisions of Section 6
hereof.
		
	Wiring and ACH Instructions for Rent Payment:	  	
Bank:                         Bank
of America
 Account Name:         150 Second Street LLC

Account Number:     4427702408
 ACH
Routing /ABA Number: 111000012
 Wire Routing /ABA Number: 026009593

Bank Address:
 Mail
Code:                GA1-006-09-10

                          
        Atlanta Plaza Building

                          
        600 Peachtree St NE

                          
        Atlanta, GA 30308-2265

		
	Parking:	  	As set forth in Section 7.
		
	Security Deposit:	  	$1,253,097.48 subject to the terms and conditions set forth in Section 27.
		
	General Liability Insurance:	  	$2,000,000.00 per occurrence/$3,000,000.00 aggregate (combined single limit) for property damage, bodily injury and death.
		
	Right of First Offer:	  	As set forth in Section 29.
		
	Landlord’s Notice Address:	  	 c/o Skanska USA Commercial Development Inc.

253 Summer Street
 Boston, MA 02210

Attn: Charles Leatherbee



  
 3 









			
	Tenant’s Notice Address:	  	 Prior to the Lease Commencement Date:
  

840 Memorial Drive
 Cambridge, MA 02139

Attention: Linda Bain
  

After the Lease Commencement Date:
  

150 Second Street
 Cambridge, MA 02139

Attention: Linda Bain

		
	Brokers:	  	Jones Lang LaSalle and Colliers International New England LLC

 The following Exhibits and Addenda are attached hereto and incorporated herein by this reference: 

EXHIBIT A - PLAN OF PREMISES, STORAGE SPACES AND SHARED SPACES 

EXHIBIT B - DESCRIPTION OF PROJECT 
 EXHIBIT
C - ACKNOWLEDGMENT OF LEASE COMMENCEMENT DATE 
 EXHIBIT D - RENT CERTIFICATE 

EXHIBIT E - BASE BUILDING SPECIFICATIONS 

EXHIBIT F - LANDLORD TENANT MATRIX 
 EXHIBIT
G - TENANT’S CONCEPT PLAN 
 EXHIBIT H - TENANT DESIGN AND CONSTRUCTION GUIDELINES 

EXHIBIT I - PARKING PLAN 
 EXHIBIT J -
RULES AND REGULATIONS 

  
 4 









	 	1.2	Definitions. 

 “Abated Base Rent” shall have the meaning set
forth in Section 4.2 hereof. 
 “ADA” shall mean the Americans With Disabilities Act, 42 U.S.C. §
12101, et seq., together with the regulations promulgated pursuant thereto. 
 “Additional Rent” shall have the meaning set
forth in Section 4.3 hereof. 
 “AIA” shall mean the American Institute of Architects. 

“Alterations” shall have the meaning set forth in Section 9.1 hereof. 

“Annual Estimate” shall have the meaning set forth in Section 4.4 hereof. 

“Annual Statement” shall have the meaning set forth in Section 4.4 hereof. 

“Arbitrator” shall mean any person appointed by or on behalf of either party or appointed pursuant to the provisions hereof
and: (i) shall be (A) a member of the American Institute of Real Estate Appraisers with not less than 10 years of experience in the appraisal of improved office and high tech and life sciences laboratory real estate in the greater Boston,
Massachusetts metropolitan area, or (B) a licensed commercial real estate broker with not less than 15 years experience representing landlords and/or tenants in the leasing of high tech or life sciences laboratory space in the greater Boston,
Massachusetts metropolitan area, (ii) devoting substantially all of their time to professional appraisal or brokerage work, as applicable, at the time of appointment and (iii) be in all respects impartial and disinterested. 

“Assignment Date” shall have the meaning set forth in Section 17.2 hereof. 

“Assignment Notice” shall have the meaning set forth in Section 17.2 hereof. 

“Assignment Termination” shall have the meaning set forth in Section 17.2 hereof. 

“Base Rent” shall have the meaning set forth in Section 1.1 hereof. 

“Base Rent Abatement Period” shall have the meaning set forth in Section 4.2 hereof. 

“Base Term” shall have the meaning set forth in Section 1.1 hereof. 

“Business Day” shall mean any day other than (a) a Saturday or Sunday and (b) any Federal holiday or (c) a day
on which banks are not open for business generally in the Commonwealth of Massachusetts. 
 “Broker” shall have the meaning
set forth in Section 1.1 hereof. 
 “Building Systems” shall mean the structural, exterior, parking and
other Common Areas of the Project, including HVAC, plumbing, fire sprinklers, electrical, elevators and all other building systems serving the Premises and other portions of the Project. 

  
 5 








 “Claims” shall have the meaning set forth in Section 6.1
hereof. 
 “Common Areas” shall mean the portions of the Project which are for the non-exclusive use of tenants of the
Project. 
 “Default Rate” shall mean an annual rate equal to the lesser of 12% per annum or the highest rate
permitted by law. 
 “Default” shall have the meaning set forth in Section 16.1 hereof. 

“Environmental Claims” shall have the meaning set forth in Section 21.1. 

“Environmental Requirements” shall have the meaning set forth in Section 21.8 hereof. 

“Excess Rent” shall have the meaning set forth in Section 17.4 hereof. 

“Expense Information” shall have the meaning set forth in Section 4.4 hereof. 

“Extension Proposal” shall have the meaning set forth in Section 28.2 hereof. 

“Extension Right” shall have the meaning set forth in Section 28.1 hereof. 

“Extension Term” shall have the meaning set forth in Section 28.1 hereof. 

“Force Majeure” shall have the meaning set forth in Section 30.20 hereof. 

“Governmental Authority” shall have the meaning set forth in Section 4.6 hereof. 

“Haz Mat Documents” shall have the meaning set forth in Section 21.2 hereof. 

“Hazardous Materials Clearances” shall have the meaning set forth in Section 14.1 hereof. 

“Hazardous Materials List” shall have the meaning set forth in Section 21.2 hereof. 

“Hazardous Materials” shall have the meaning set forth in Section 21.8 hereof. 

“Holder” shall have the meaning set forth in Section 19.1 hereof. 

“Independent Review” shall have the meaning set forth in Section 4.4 hereof. 

“Installations” shall have the meaning set forth in Section 9.1 hereof. 

“Landlord’s Work” shall have the meaning set forth in Section 5.1 hereof. 

“Legal Requirement(s)” shall mean all laws, orders, judgments, ordinances, regulations, codes, directives, permits, licenses,
covenants and restrictions now or hereafter applicable to the Project, and to the use and occupancy thereof, including, without limitation, the ADA. 

  
 6 








 “Letter of Credit” shall have the meaning set forth in
Section 27.1 hereof. 
 “Market Rate” shall have the meaning set forth in
Section 28.1 hereof. 
 “Maximum Restoration Period” shall have the meaning set forth in
Section 14.1 hereof. 
 “Memorial Drive Lease” shall have the meaning set forth in
Section 4.2 hereof. 
 “Memorial Drive Rent Savings Event” shall have the meaning set forth in
Section 4.2 hereof. 
 “Mortgage” shall have the meaning set forth in Section 19.1
hereof. 
 “OFAC” shall mean the Office of Foreign Assets Control of the U.S. Department of Treasury. 

“OFAC Rules” shall mean the rules of OFAC and any statute, executive order, or regulation relating thereto. 

“Operating Expenses” shall have the meaning set forth in Section 4.4 hereof. 

“Permitted Assignment” shall have the meaning set forth in Section 17.2 hereof. 

“Permitted Use” shall have the meaning set forth in Section 1.1 hereof. 

“Premises” shall have the meaning set forth in Section 1.1 hereof. 

“Proceeding for Relief” shall have the meaning set forth in Section 16.1(f) hereof. 

“Project” shall have the meaning set forth in Section 1.1 hereof. 

“Related Parties” shall have the meaning set forth in Section 13.1 hereof. 

“Removable Installations” shall have the meaning set forth in Section 9.1 hereof. 

“Rent” shall mean Base Rent, Tenant’s Share of Operating Expenses and all other amounts payable by Tenant to Landlord
hereunder. 
 “Rent Abatement” shall have the meaning set forth in Section 4.2 hereof. 

“Rent Abatement Conditions” shall have the meaning set forth in Section 4.2 hereof. 

“Rentable Area of the Premises” shall have the meaning set forth in Section 1.1 hereof. 

“Rentable Area of the Project” shall have the meaning set forth in Section 1.1 hereof. 

“Rent Adjustment Percentage” shall mean three percent (3%). 

“Rent Certificate” shall have the meaning set forth in Section 4.2 hereof. 

  
 7 








 “Security Deposit” shall have the meaning set forth in
Section 27.1 hereof. 
 “Substantial Completion” or “Substantially Complete” shall have
the meaning set forth in Section 5.4. 
 “Surrender Plan” shall have the meaning set forth in
Section 20.1 hereof. 
 “Taking” and “Taken” shall have the meaning set forth in
Section 15.1 hereof. 
 “Taxes” shall have the meaning set forth in Section 4.5
hereof. 
 “Tenant HazMat Operations” shall have the meaning set forth in Section 20.1 hereof. 

“Tenant Parties” shall have the meaning set forth in Section 10.1 hereof. 

“Tenant’s Property” shall have the meaning set forth in Section 9.1 hereof. 

“Tenant’s Share of Operating Expenses” shall have the meaning set forth in Section 1.1 hereof. 

“Tenant’s Share” shall mean the percentage set forth in the Basic Lease Provisions as Tenant’s Share as reasonably
adjusted by Landlord for changes in the physical size of the Premises or the Project occurring thereafter. 
 “Tenant’s
Work” shall have the meaning set forth in Section 5.2. 
 “Utilities” shall have the meaning
set forth in Section 8.1 hereof. 
 “Restoration Period” shall have the meaning set forth in
Section 14.1 hereof. 
 ARTICLE 2 

PREMISES; APPURTENANT RIGHTS; RESERVATIONS 

2.1 Lease of Premises. Upon and subject to all of the terms and conditions hereof, Landlord hereby leases the Premises to Tenant
and Tenant hereby leases the Premises from Landlord. 
 Excepted and excluded from the Premises and the Common Areas (as defined below) are
the ceiling, floor, perimeter walls and exterior windows (except the inner surface of each thereof), and any space in the Premises used for shafts, stacks, pipes, conduits, fan rooms, ducts, electric or other utilities, sinks or other Building
facilities, but the entry doors to the Premises are a part thereof, together with related glass and finish work. Landlord shall have the right to place in the Premises interior sun control devices, utility lines, cables and wiring, equipment,
stacks, pipes, conduits, ducts and the like, provided that any such installations shall be located above the ceiling or within the walls (except for the interior sun control devices which shall be located in or near the windows) and shall not
otherwise materially interfere with Tenant’s use, or materially reduce the rentable square footage of the Premises. 

  
 8 








 2.2 Appurtenant Rights. Subject to the matters set forth in the following
paragraph, Tenant shall have, as appurtenant to the Premises, the non-exclusive right to use, and permit its invitees to use in common with Landlord and others, the following areas of the Property (collectively, the “Common
Areas”) (i) public or common lobbies, hallways, stairways, elevators (including but not limited to freight elevators) and common walkways necessary for access to the Building and the Premises, and if the portion of the Premises on
any floor includes less than the entire floor, any common toilets, any corridors required for access to the Premises and any elevator lobby of such floor; and (ii) the access roads, driveways, parking areas (as the same may be designated or
modified by Landlord from time to time), loading areas, pedestrian sidewalks, landscaped areas, trash enclosures (including but not limited to dumpsters maintained on the premises by Landlord), if any, and other areas or facilities, if any, which
are located in or on the Property and designated by Landlord from time to time for the non-exclusive use of tenants and other occupants of the Building. 

Landlord has designated certain areas located on the penthouse, ground level and garage level of the Building for Storage Space and Shared
Space, as shown on the plan attached hereto as Exhibit A, for use by the tenants of the Building. Tenant shall be allocated Tenant’s Share of the Storage Space and Shared Space, the location and use of which shall be reasonably
determined by Landlord and Tenant subject to applicable Legal Requirements, circulation requirements and Landlord’s reasonable requirements and conditions (including, without limitation, consideration for the utility of the unused portions of
the Storage Space and Shared Space by other tenants of the Building). The Storage Space and Shared Space shall be leased to Tenant on all of the terms and conditions of this Lease which are applicable to the Premises except as follows: (i) the
rent for Tenant’s Share of the Storage Space shall be the then applicable market rate (currently $18.00 per RSF); (ii) Landlord shall not have any obligation to make any improvements or alterations to the Storage Space and Shared Space to
prepare such space for Tenant’s use; (iii) Tenant shall use Tenant’s Share of the Storage Space and Shared Space solely for the storage or use of Tenant’s property or equipment and for no other purpose and in accordance with all
applicable Legal Requirements; (iv) Tenant, at its sole expense, shall keep Tenant’s Share of the Storage Space and Shared Space clean and in good condition; and (vi) Landlord shall not be required to provide any services for the
Storage Space and Shared Space. Notwithstanding the foregoing, as of the Effective Date, Tenant shall be deemed to have elected to lease the entire amount of Storage Space allocated to Tenant at the rate of $18.00 per RSF (gross) for the Term. If
Tenant subsequently elects to surrender any or all of such Storage Space to Landlord, Landlord may offer the surrendered Storage Space to other tenants in the Building and Tenant’s right to lease such surrendered Storage Space thereafter will
be subject to availability at such future time and Tenant’s payment at the then applicable market rental rate. 
 Notwithstanding any
provision herein to the contrary, Tenant’s rights under this Lease shall always be subject to (a) reservations, restrictions, easements and encumbrances of record, as amended from time to time, (b) such reasonable rules and
regulations from time to time established by Landlord with respect to the Property pursuant to Section 30.18 (the “Rules and Regulations”), and (c) Landlord’s reservations set forth in
Section 2.3 below or elsewhere in this Lease. 

  
 9 








 2.3 Landlord Reservations. Notwithstanding any provision herein to the contrary,
Landlord reserves the right to: (i) grant, modify and terminate easements and other encumbrances so long as the same do not materially and adversely interfere with the Permitted Use by Tenant, (ii) designate and change from time to time
areas and facilities so to be used; provided however, that Landlord shall be responsible for any costs incurred in moving any of Tenant’s personnel, furniture, fixtures or equipment, (iii) make additions to the Building,
(iv) construct other buildings and improvements at the Property, (v) post “For Sale” and “For Lease” signs on the Property at any time during the Term, and (vi) change the name and street address of the Building
(provided, in such event, Landlord shall reimburse Tenant for its costs to implement such changes). Landlord reserves the right, at any time and from time to time, to make such changes, alterations, additions, improvements, repairs or replacements
in or to the Project (including the Premises but, with respect to the Premises, only for purposes of repairs, maintenance, replacements and other rights expressly reserved to Landlord herein) and the fixtures and equipment therein, as well as in or
to the street entrances and/or the Common Areas, as it may reasonably deem necessary or desirable, provided, however, that there be no material obstruction or modification of access to, or material interference with the use or enjoyment of, the
Premises or parking spaces by Tenant. Subject to the foregoing, provided reasonable prior written notice is given to Tenant and Tenant’s access to the Premises is not prohibited, Landlord shall have the right to temporarily close all, or any
portion, of the Common Areas for the purpose of making repairs or changes thereto. 
 ARTICLE 3 

DELIVERY OF PREMISES; ACCEPTANCE  

3.1 Delivery of Premises; Acceptance of Premises. Landlord shall deliver the Premises to Tenant upon the Effective Date
provided that Tenant has delivered the Security Deposit to Landlord and complied with the requirements of Article 13. Except as set forth in this Section 3.1 and Section 5.1(a), if applicable: (i) Tenant shall accept the Premises in
their condition as of the time of delivery, subject to all applicable Legal Requirements (as defined in Article 6 hereof); (ii) Landlord shall have no obligation for any defects in the Premises; and (iii) Tenant’s taking
possession of the Premises shall be conclusive evidence that Tenant accepts the Premises with Landlord’s Work completed pursuant to Section 5.1(a). 

Tenant agrees and acknowledges that, except as otherwise set forth in this Lease, neither Landlord nor any agent of Landlord has made any
representation or warranty with respect to the condition of all or any portion of the Premises or the Project, and/or the suitability of the Premises or the Project for the conduct of Tenant’s business, and Tenant waives any implied warranty
that the Premises or the Project are suitable for the Permitted Use. Notwithstanding the foregoing, Landlord represents to its knowledge that general office, research and development and laboratory uses are permitted uses pertaining to the Building
under the Zoning Ordinance of the City of Cambridge. This Lease constitutes the complete agreement of Landlord and Tenant with respect to the subject matter hereof and supersedes any and all prior representations, inducements, promises, agreements,
understandings and negotiations which are not contained herein. Landlord in executing this Lease does so in reliance upon Tenant’s representations, warranties, acknowledgments and agreements contained herein. 

3.2 Acknowledgment of Lease Commencement Date. Upon request of Landlord, Tenant shall execute and deliver a written
acknowledgment of the Lease Commencement Date, Rent Commencement Date and the expiration date of the Term when such dates are established in accordance with the requirements of this Lease substantially in the form of the “Acknowledgement


  
 10 








 
of Lease Commencement Date” attached to this Lease as Exhibit C; provided, however, Tenant’s failure to execute and deliver such acknowledgment shall not affect
Landlord’s rights hereunder. The “Term” of this Lease shall be the Base Term, as defined above on the first page of this Lease and, if applicable, the Extension Term which Tenant may elect pursuant to Article 28
hereof. 
 ARTICLE 4 

RENT 
 4.1
Base Rent. The first month’s Base Rent shall be due and payable on the Lease Commencement Date and the Security Deposit shall be due and payable on delivery of an executed copy of this Lease to Landlord. Tenant shall pay to Landlord
in advance, without demand, abatement, deduction or set-off, equal monthly installments of Base Rent on or before the first day of each calendar month during the Term hereof, in lawful money of the United States of America, at the office of Landlord
for payment of Rent set forth above, or to such other person or at such other place as Landlord may from time to time designate in writing. Payments of Base Rent for any fractional calendar month shall be prorated. The obligation of Tenant to pay
Base Rent and other sums to Landlord and the obligations of Landlord under this Lease are independent obligations. Tenant shall have no right at any time to abate, reduce, or set-off any Rent (as defined in Section 1.2) due hereunder except for
any abatement, reduction or set-off as may be expressly provided in this Lease. 
 4.2 Base Rent Abatement Period.
Notwithstanding anything in this Section of the Lease to the contrary, so long as Tenant is not in Default (as defined in Section 16.1) under this Lease, Tenant shall be entitled to an abatement of Base Rent in the amount of $208,849.58 per
month for six (6) consecutive full calendar months of the Base Term beginning on the Lease Commencement Date (“Rent Abatement”). The period during which the foregoing Base Rent abatement rights are in effect shall be
referred to as the “Base Rent Abatement Period” and the amount of Base Rent permitted to be abated shall be referred to as the “Abated Base Rent”. During the Base Rent Abatement Period, only Base Rent
shall be abated as provided in this Section, and all Additional Rent and other costs and charges specified in this Lease shall remain as due and payable pursuant to the provisions of this Lease. 

As an inducement to Tenant’s entering into this Lease, Landlord offers the Rent Abatement in order to offset Tenant’s rent
obligation under its current lease pertaining to the premises located at 840 Memorial Drive, Cambridge, Massachusetts (“Memorial Drive Lease”), a true, accurate and complete copy of which Tenant shall provide to Landlord
prior to the Effective Date of this Lease. Accordingly, Landlord and Tenant agree that if Tenant’s out of pocket rent obligation under the Memorial Drive Lease is reduced or eliminated by virtue of entering into an assignment or sublease,
termination agreement or suffering a recapture of such premises or other such means (each, a “Memorial Drive Rent Savings Event”), Landlord and Tenant shall split Tenant’s rent savings under the Memorial Drive Lease on a
60% to Landlord and 40% to Tenant basis after the deduction of reasonable documented transaction costs, including, but not limited to legal and brokerage fees and tenant improvement allowances. 

  
 11 








 In order to receive the Rent Abatement and to account for the occurrence of a Memorial Drive Rent
Savings Event, Tenant shall comply with the following requirements (collectively, the “Rent Abatement Conditions”): 
  

	 	i.	Upon the Lease Commencement Date and the first day of each successive month thereafter until the expiration or earlier termination of the term of the Memorial Drive Lease, Tenant shall deliver to Landlord a Rent
Certificate substantially in the form attached hereto as Exhibit D (“Rent Certificate”) whereby Tenant certifies to Landlord, among other things, the amount of Tenant’s actual out of pocket rent payment
under the Memorial Drive Lease for the applicable monthly period. 

  

	 	ii.	Upon Landlord’s receipt of the Rent Certificate, Tenant’s obligation to pay the Base Rent for the applicable month shall abate. 


If the Rent Certificate indicates that a Memorial Drive Rent Savings Event has occurred, the amount of the Rent Abatement that may be applied
to Base Rent hereunder shall be reduced by the portion of the rent savings allocated to Landlord as Tenant realizes the actual rent savings under the Memorial Drive Lease. If a Memorial Drive Rent Savings Event has occurred and the amount of the
rent savings under the Memorial Drive Lease is greater than the remaining amount of the Rent Abatement at such time, then Tenant shall pay Landlord, as additional rent, the rent savings allocated to Landlord amortized over the remainder of the
stated term of the Memorial Drive Lease. The following examples illustrate three (but not all) possible scenarios that may arise in any given month during the Base Rent Abatement Period under this Section: 

(a) No Memorial Drive Rent Savings Event Occurs Before the Expiration of the Base Rent Abatement Period: 

 

	 	1.	Tenant submits a Rent Certificate to Landlord evidencing that no Memorial Drive Rent Savings Event has occurred. 

  

	 	2.	Tenant pays the monthly base rent of approximately $35.290.60 to landlord under the Memorial Drive Lease. 

  

	 	3.	The Monthly Base Rent of $208,849.58 due to Landlord pursuant to Section 1.1 hereof is abated. 


(b) Memorial Drive Rent Savings Event Occurs Before the Expiration of the Base Rent Abatement Period: 

 

	 	1.	Tenant submits a Rent Certificate to Landlord evidencing that Tenant and the landlord under the Memorial Drive Lease have entered into a lease termination agreement (i.e. a Memorial Drive Rent Savings Event) yielding a
rent savings of $500,000 (after deduction of Tenant’s reasonable documented transaction costs). 

  

	 	2.	Landlord’s share of the rent savings is $300,000 and Tenant’s share of the rent savings is $200,000. 

  

	 	3.	Tenant pays the net monthly rent (or no monthly rent, as the case may be) due to landlord under the Memorial Drive Lease after accounting for the rent savings under the Memorial Drive Lease. 


  
 12 









	 	4.	The amount of Rent Abatement that may be applied to Base Rent is reduced by $300,000 (the amount of Landlord’s share of the rent savings). Therefore, Tenant pays Base Rent of $208,849.58 to Landlord plus additional
rent of $91,150.42 ($208,849.58 + $91,150.42 = $300,000 rent savings due Landlord). 

 (c) Memorial Drive Rent
Savings Event Occurs After the Expiration of the Base Rent Abatement Period: 
  

	 	1.	Tenant submits a Rent Certificate to Landlord evidencing that Tenant and the landlord under the Memorial Drive Lease have entered into a lease termination agreement (i.e. a Memorial Drive Rent Savings Event) yielding a
rent savings of $500,000 (after deduction of Tenant’s reasonable documented transaction costs). 

  

	 	2.	Landlord’s share of the rent savings is $300,000 and Tenant’s share of the rent savings is $200,000. 

  

	 	3.	Tenant pays the net monthly rent (or no monthly rent, as the case may be) due to landlord under the Memorial Drive Lease after accounting for the rent savings under the Memorial Drive Lease. 


 

	 	4.	Assuming five months remaining in the term under the Memorial Drive Lease, the monthly amount of the Landlord’s share of the rent savings amortized on a straight line basis over the unexpired portion of the term
under the Memorial Drive Lease is $60,000 ($300,000 ÷ 5 months). 

  

	 	5.	Tenant pays the applicable monthly Rent to Landlord due under this Lease plus additional rent of $60,000 for five consecutive months. 


In the event of any inconsistency or conflict between the numeric examples provided above and the written provisions set forth in this
Section, the written text shall govern. 
 If Tenant fails to comply with the requirements set forth in this Section 4.2, Tenant shall
be obligated to pay the applicable Base Rent. If a Rent Certificate is inaccurate or if Tenant and Landlord have failed to properly account for a previously-occurring Memorial Drive Rent Savings Event, then Tenant shall be obligated to prepare and
deliver a Rent Certificate addressing such inaccuracy or failure and shall pay to Landlord the Landlord’s share of any previously Abated Base Rent. 

4.3 Additional Rent. In addition to Base Rent, commencing on the Lease Commencement Date, Tenant agrees to pay to Landlord as
additional rent (“Additional Rent”): (i) Tenant’s Share of “Operating Expenses” (as defined in Section 4.5), and (ii) any and all other amounts Tenant assumes or agrees to pay to Landlord under
the provisions of this Lease, including, without limitation, any and all other sums that may become due by reason of any default of Tenant or failure to comply with the agreements, terms, covenants and conditions of this Lease to be performed by
Tenant, after any applicable notice and cure period. 

  
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 4.4 Intentionally Omitted. 

4.5 Operating Expense Payments. Landlord shall deliver to Tenant a written estimate of Operating Expenses for each calendar year
during the Term (the “Annual Estimate”) which may be revised by Landlord from time to time during such calendar year. During each month of the Term commencing on the Lease Commencement Date, on the same date that Base Rent is
due, Tenant shall pay Landlord an amount equal to 1/12th of Tenant’s Share of the Annual Estimate. Payments for any fractional calendar month shall be prorated. If Landlord fails to give Tenant the Annual Estimate prior to the beginning of any
calendar year, Tenant shall continue to pay Operating Expenses in accordance with the previous Annual Estimate, until Tenant receives a new statement from Landlord. 

The term “Operating Expenses” means all costs and expenses of any kind or description whatsoever incurred or accrued
each calendar year by Landlord in operating, maintaining, repairing, and managing the Building and the Project including, without duplication, Taxes (as defined in Section 4.5), capital repairs and improvements (1) reasonably
projected to reduce the amount of Operating Expenses payable by Tenant, or (2) required to comply with any Legal Requirements that first become effective and applicable to the Project after the date of this Lease, amortized over-the useful life
of such capital items as determined in accordance with generally accepted accounting principles, costs for transportation services for the benefit of the tenants of the Building and a property management fee at fair market rates not to exceed 3.0%
of Base Rent, excluding only: 
 (a) the original construction costs of the Project and renovation prior to the date of the Lease and
costs of correcting defects in such original construction or renovation (including Landlord’s Work); 
 (b) capital expenses for
the Project except as expressly permitted above; 
 (c) interest, principal and other payments pursuant to a Mortgage (as defined in
Section 19.1) debts of Landlord, ground rent, financing costs and amortization of funds borrowed by Landlord, whether secured or unsecured; 

(d) depreciation of the Project (except for capital improvements, the cost of which are includable in Operating Expenses); 

(e) advertising, promotional, legal and space planning expenses and leasing commissions and other costs and expenses incurred in
procuring and leasing space to tenants for the Project, including any leasing office maintained in the Project, free rent and construction allowances for tenants; 

(f) legal and other expenses incurred in the negotiation or enforcement of leases; 

(g) completing, fixturing, improving, renovating, painting, redecorating or other work, which Landlord pays for or performs for other
tenants within their premises, and costs of correcting defects in such work; 

  
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 (h) costs to be reimbursed by other tenants of the Project or Taxes to be paid directly by
Tenant or other tenants of the Project, whether or not actually paid; 
 (i) The cost of any work or services performed for any other
property other than the Project, including, without limitation, salaries, wages, benefits and other compensation paid to employees of Landlord who are not assigned in whole or in part to the operation, management, maintenance or repair of the
Project; 
 (j) salaries, wages, benefits and other compensation paid to officers and executives of Landlord and administrative
employees above the grade of property manager or building supervisor and Landlord’s general overhead; 
 (k) general
organizational, administrative and overhead costs relating to maintaining Landlord‘s existence, either as a corporation, partnership, or other entity, including general corporate, legal and accounting expenses; 

(l) costs (including attorneys’ fees and costs of settlement, judgments and payments in lieu thereof) incurred in connection with
disputes with tenants, other occupants, or prospective tenants, and costs and expenses, including legal fees, incurred in connection with negotiations or disputes with employees, consultants, management agents, leasing agents, purchasers or
mortgagees of the Building; 
 (m) costs incurred by Landlord due to the violation by Landlord, its employees, agents or contractors
or any tenant of the terms and conditions of any lease of space in the Project or any Legal Requirement (as defined in Section 1.2); 

(n) penalties, fines or interest incurred as a result of Landlord‘s inability or failure to make payment of Taxes and/or to file
any tax or informational returns when due, or from Landlord’s failure to make any payment of Taxes required to be made by Landlord hereunder before delinquency; 

(o) overhead and profit increment paid to Landlord or to subsidiaries or affiliates of Landlord for goods and/or services in or to the
Project to the extent the same exceeds the costs of such goods and/or services rendered by unaffiliated third parties on a competitive basis; 

(p) costs of Landlord’s charitable or political contributions, or of fine art maintained at the Project; 

(q) costs in connection with services (including electricity), items or other benefits of a type which are not standard for the Project
and which are not available to Tenant without specific charges therefor, but which are provided to another tenant or occupant of the Project, whether or not such other tenant or occupant is specifically charged therefor by Landlord; 

(r) costs incurred in the sale or refinancing of the Project; 

(s) costs for remediation, abatement, removal or encapsulation of Hazardous Materials at the Project other than routine cleaning and
maintenance which may involve the same; 

  
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 (t) net income taxes of Landlord or the owner of any interest in the Project, franchise,
capital stock, gift, estate or inheritance taxes or any federal, state or local documentary taxes imposed against the Project or any portion thereof or interest therein; and 

(u) any expenses otherwise includable within Operating Expenses to the extent actually reimbursed by persons other than tenants of the
Project under leases for space in the Project. 
 Within 90 days after the end of each calendar year (or such longer period as may be
reasonably required), Landlord shall furnish to Tenant a statement (an “Annual Statement”) showing in reasonable detail: (a) the total and Tenant’s Share of actual Operating Expenses for the previous calendar year,
and (b) the total of Tenant’s payments in respect of Operating Expenses for such year. If Tenant’s Share of actual Operating Expenses for such year exceeds Tenant’s payments of Operating Expenses for such year, the excess shall
be due and payable by Tenant as Rent within 30 days after delivery of such Annual Statement to Tenant. If Tenant’s payments of Operating Expenses for such year exceed Tenant’s Share of actual Operating Expenses for such year, the excess
shall be credited against the next due amounts of Rent, provided that any overpayment shall be paid to Tenant within thirty (30) days if the Term has ended, provided that if Tenant is delinquent in its obligation to pay Base Rent or Additional
Rent, Landlord shall pay the excess to Tenant after deducting all other amounts due Landlord. 
 The Annual Statement shall be final and
binding upon Tenant unless Tenant, within 90 days after Tenant’s receipt thereof, shall contest any item therein by giving written notice to Landlord, specifying each item contested and the reason therefor. If, during such 90 day period, Tenant
reasonably and in good faith questions or contests the accuracy of Landlord’s statement of Tenant’s Share of Operating Expenses, provided that Tenant pays any amount due on the Annual Statement if applicable, Landlord will provide Tenant
with access to Landlord’s books and records relating to the operation of the Project and such information as Landlord reasonably determines to be responsive to Tenant’s questions (the “Expense Information”). If
Landlord and Tenant cannot agree upon the amount of Tenant’s Share of Operating Expenses within thirty (30) days after Tenant’s review of such Expense Information, then Tenant shall have the right to have an independent public
accounting firm selected by Tenant, working pursuant to a fee arrangement other than a contingent fee (at Tenant’s sole cost and expense) and approved by Landlord (which approval shall not be unreasonably withheld, conditioned or delayed),
audit and/or review the Expense Information for the year in question (the “Independent Review”). The results of any such Independent Review shall be binding on Landlord and Tenant. If the Independent Review shows that the
payments actually made by Tenant with respect to Operating Expenses for the calendar year in question exceeded Tenant’s Share of Operating Expenses for such calendar year, Landlord shall at Landlord’s option either (i) credit the
excess amount to the next succeeding installments of estimated Operating Expenses or (ii) pay the excess to Tenant within 30 days after delivery of such statement, except that after the expiration or earlier termination of this Lease or if
Tenant is delinquent in its obligation to pay Rent, Landlord shall pay the excess to Tenant after deducting all other amounts due Landlord. If the Independent Review shows that Tenant’s payments with respect to Operating Expenses for such
calendar year were less than Tenant’s Share of Operating Expenses for the calendar year, Tenant shall pay the deficiency to Landlord within 30 days after delivery of such statement. If the Independent Review shows that Tenant has overpaid with
respect to Operating Expenses stated in the Annual Statement or any adjustments made 

  
 16 








 
thereafter by more than 5% then Landlord shall reimburse Tenant for all costs incurred by Tenant for the Independent Review. Operating Expenses for the calendar years in which Tenant’s
obligation to share therein begins and ends shall be prorated. Notwithstanding anything set forth herein to the contrary, if the Project is not at least 95% occupied on average during any year of the Term, Tenant’s Share of Operating Expenses
that vary according to occupancy of the Project for such year shall be computed as though the Project had been 95% occupied on average during such year. 

“Tenant’s Share” shall be the percentage set forth on the first page of this Lease as Tenant’s Share as
reasonably adjusted by Landlord for changes in the physical size of the Premises or the Project occurring thereafter. Landlord may equitably adjust Tenant’s Share for any item of expense or cost reimbursable by Tenant that relates to a repair,
replacement, or service that benefits only the Premises or only a portion of the Project that includes the Premises, which adjustment may be reviewed by Tenant as part of the Independent Review. Base Rent, Tenant’s Share of Operating Expenses
and all other amounts payable by Tenant to Landlord hereunder are collectively referred to herein as “Rent.” 

4.6 Taxes. Tenant shall pay, as part of Operating Expenses, all taxes, levies, fees, assessments and governmental charges of any
kind, existing as of the Lease Commencement Date or thereafter enacted (collectively referred to as “Taxes”), imposed by any federal, state, regional, municipal, local or other governmental authority or agency, including,
without limitation, quasi-public agencies (collectively, “Governmental Authority”) during the Term, including, without limitation, all Taxes: (i) imposed on or measured by or based, in whole or in part, on rent payable
to (or gross receipts received by) Landlord under this Lease and/or from the rental by Landlord of the Project or any portion thereof, or (ii) based on the square footage, assessed value or other measure or evaluation of any kind of the
Premises or the Project, or (iii) assessed or imposed by or on the operation or maintenance of any portion of the Premises or the Project, including parking, or (iv) assessed or imposed by, or at the direction of, or resulting from Legal
Requirements, or interpretations thereof, promulgated by any Governmental Authority, or (v) imposed as a license or other fee, charge, tax, or assessment on Landlord’s business or occupation of leasing space in the Project. The prorated
portion of any Taxes that are due and payable pertaining to periods prior to the Lease Commencement Date or after the expiration of the Term shall not be Tenant’s obligation to pay hereunder. Landlord may contest by appropriate legal
proceedings the amount, validity, or application of any Taxes or liens securing Taxes. If a change in Taxes is obtained for any year of the Term during which Tenant paid Tenant’s Share of Taxes, then Taxes for that year will be retroactively
adjusted and Landlord shall provide Tenant with a credit, if any, based on the adjustment. Taxes shall not include any net income taxes imposed on Landlord except to the extent such net income taxes are in substitution for any Taxes payable
hereunder. If any such Tax is levied or assessed directly against Tenant, then Tenant shall be responsible for and shall pay the same at such times and in such manner as the taxing authority shall require. Tenant shall pay, prior to delinquency, any
and all Taxes levied or assessed against any personal property or trade fixtures placed by Tenant in the Premises, whether levied or assessed against Landlord or Tenant. If any Taxes on Tenant’s personal property or trade fixtures are levied
against Landlord or Landlord’s property, or if the assessed valuation of the Project is expressly increased by the taxing authority by a value attributable to improvements in or alterations to the Premises, whether owned by Landlord or Tenant
and whether or not affixed to the real property so as to become a part thereof, higher than the base valuation on which Landlord 

  
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from time-to-time allocates Taxes to all tenants in the Project, Landlord shall have the right, but not the obligation, to pay such Taxes. Landlord’s determination of any excess assessed
valuation shall be binding and conclusive, absent manifest error. The amount of any such payment by Landlord shall constitute Additional Rent due from Tenant to Landlord within thirty (30) days. 

ARTICLE 5 
 CONDITION
OF PREMISES; CONSTRUCTION 
 5.1 Base Building Work. 

(a) Landlord shall deliver the Premises to Tenant upon the Effective Date with the work (“Landlord’s
Work”) more particularly described in the base building specifications attached hereto as Exhibit E (“Base Building Specifications”) completed. Landlord’s Work shall comply with the Legal
Requirements and shall be consistent with Class A standards for laboratory and office space, and substantially in conformance with, and not materially inconsistent with, the Base Building Specifications. Landlord shall deliver the Premises to
Tenant with all base building systems, including, but not limited to, HVAC, electrical, life safety and plumbing systems in good working order, in compliance with applicable Legal Requirements and suitable for laboratory purposes. The allocation of
the responsibilities between the Landlord’s Work and Tenant’s Work is set forth on the Landlord/Tenant Matrix attached hereto as Exhibit F (“Landlord/Tenant Matrix”). 

(b) Tenant agrees, except as otherwise provided herein to the contrary, (i) to accept possession of the Premises in the condition
described in the Base Building Specifications and otherwise in “as is” condition, (ii) that neither Landlord nor Landlord’s agents have made any representations or warranties with respect to the Premises or the Building except as
provided herein, and (iii) Landlord has no obligation to perform any work, supply any materials, incur any expense or make any alterations, additions or improvements to the Premises to prepare the Premises for Tenant’s use and occupancy
except as provided herein. 
 5.2 Tenant’s Work. 

(a) Tenant shall prepare, at its sole cost and expense (against which the Landlord’s Contribution may be applied), a set of
design/development plans in substantial conformity with the concept plan approved by Landlord (subject to Landlord’s review of further details regarding access and maintenance of the tel/data room and access, maintenance and ventilation issues
in connection with components located on the third floor along the window line) and attached hereto as Exhibit G, Tenant Design and Construction Guidelines attached hereto as Exhibit H (“Tenant Design and
Construction Guidelines”) and the allocation of responsibilities set forth in the Landlord/Tenant Matrix sufficient for Landlord to approve Tenant’s proposed design of the Premises (“Design/Development
Plans”), and a full set of final permit-ready construction drawings (“Final Construction Drawings”) for the interior finish and layout of the initial improvements (“Tenant’s Work”)
which Tenant desires to have performed in the Premises. The Design/ Development Plans and the Final Construction Drawings are collectively referred to herein as the “Plans.” Provided that no Default has occurred and remains
outstanding, Landlord shall reimburse Tenant up to $4,358.60 ($.10 per RSF) for out of pocket costs incurred in preparing the initial test fit of the Premises. 

  
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 (b) The Plans shall be submitted to Landlord, together with a construction budget setting
forth the anticipated costs for the Tenant’s Work, and Landlord shall approve or disapprove of the Plans, which approval shall not be unreasonably withheld, conditioned or delayed, and Landlord shall respond in any event within fifteen
(15) days of receiving them. No work shall be conducted by or on behalf of Tenant until the Final Construction Drawings have been approved for such work in writing by Landlord. At Tenant’s sole cost and expense (against which the
Landlord’s Contribution may be applied), Tenant shall cause the Plans to be revised in a manner sufficient to remedy the Landlord’s objections and/or respond to the Landlord’s concerns and for such revised Plans to be redelivered to
Landlord, and Landlord shall approve or disapprove such portions of the Plans to which Landlord previously commented within seven (7) Business Days following the date of resubmission. Landlord’s failure to timely respond to Tenant’s
submitted Plans or revised Plans shall be deemed to be approval thereof provided that upon submitting such plans, Tenant provides written notice to Landlord stating “IF LANDLORD FAILS TO RESPOND TO THE ENCLOSED PLANS WITHIN 15 DAYS (OR 7
BUSINESS DAYS AS APPLICABLE), LANDLORD’S APPROVAL SHALL BE DEEMED GIVEN PURSUANT TO SECTION 5.2(b) OF THE LEASE” in upper case boldface type in the top margin of such notice. Landlord’s approval is solely given for the benefit of
Landlord and Tenant under this Section and neither Tenant nor any third party shall have the right to rely upon Landlord’s approval of the Plans for any other purpose whatsoever. 

(c) Landlord shall not charge Tenant any coordination, overhead or contractor supervision fees in connection with Tenant’s Work;
provided, however that Landlord shall be reimbursed from the Landlord’s Contribution for any third-party, out of pocket expenses incurred by Landlord in connection with the review and approval of Tenant’s Work. 

(d) The Plans shall be stamped by a Massachusetts registered architect and engineer, such architect and engineer and Tenant’s
general contractor and subcontractors, being subject to Landlord’s prior approval, which shall not be unreasonably withheld, conditioned or delayed, and shall comply with the Legal Requirements and the requirements of the Tenant Design and
Construction Guidelines. The final approved Plans shall be in a form satisfactory to appropriate governmental authorities responsible for issuing permits, approvals and licenses required for Tenant’s Work. 

(e) Tenant’s Work shall be completed in accordance with the Plans and no material changes to Tenant’s Work shall occur
without Landlord’s approval as set forth herein. All of the Tenant’s Work shall be performed in accordance with the requirements set forth in the Tenant Design and Construction Guidelines and completed in a first class workmanlike manner.
Tenant shall be solely responsible for the effect of the Tenant’s Work on the Building’s structure and systems, whether or not Landlord has consented to the Alterations, and shall reimburse Landlord on demand for any costs incurred by
Landlord by reason of any faulty work done by Tenant or its contractors. All of Tenant’s Work shall be performed in such manner as to maintain harmonious labor relations and to minimize any material interference with Building operations or
other construction work being performed within the Building. 
 (f) Tenant shall use diligent efforts to keep the Project and
Tenant’s leasehold interest therein free of any liens or claims of liens arising from acts or omissions of Tenant, or its subtenants, contractors or others claiming by, through or under Tenant, and shall discharge or bond


  
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any such liens within ten (10) Business Days following notice to Tenant of their filing. Before commencement of any work, upon Landlord’s request, Tenant’s contractor shall provide
a payment, performance and lien indemnity bond required by Landlord. Tenant shall provide evidence of such insurance as Landlord may reasonably require, naming Landlord as an additional insured. Tenant shall indemnify Landlord and hold it harmless
from and against any cost, claim, or liability arising from any work done by or at the direction of Tenant. 
 (g) All alterations
affixed to the Premises shall become part thereof and remain therein at the end of the Term unless otherwise agreed to by Landlord and Tenant. However, if Landlord gives Tenant a notice, at the time Landlord approves the Plans, to remove any
alterations, Tenant shall do so and shall pay the cost of removal and any repair required by such removal. 
 (h) All of
Tenant’s personal property, trade fixtures, equipment, furniture, movable partitions, and any alterations not affixed to the Premises shall remain Tenant’s property, removable at any time. If Tenant fails to remove any such materials at
the end of the Term, Landlord may do so and store them at Tenant’s expense, without liability to Tenant, and may sell them at public or private sale and apply the proceeds to any amounts due hereunder, including costs of removal, storage and
sale. 
 5.3 Intentionally Deleted. 

5.4 Landlord’s Contribution. (a) As an inducement to Tenant’s entering into this Lease, Landlord
shall, subject to the terms set forth in this Section, provide to Tenant a special tenant improvement allowance for the actual costs incurred with respect to the design and hard construction costs pertaining to Tenant’s Work up to a maximum
aggregate amount of Six Million Five Hundred Thirty Seven Thousand Nine Hundred and 00/100 Dollars ($6,537,900.00) [$150.00 per RSF] less any past due expenses owed to Landlord by Tenant under this Lease (“Initial
Allowance”). 
 (b) Landlord shall pay to Tenant an amount not to exceed Landlord’s Contribution to the extent
permitted pursuant to this Section, provided that as of the date on which Landlord is required to make payment thereof pursuant to this Section: (i) this Lease is in full force and effect, and (ii) no Event of Default then exists. Tenant
shall pay all costs of the Tenant’s Work in excess of Landlord’s Contribution. Before Tenant submits a requisition request for any hard construction costs, Landlord agrees to fund up to fifty percent (50%) of Tenant’s early
design fees from Landlord’s Contribution, with the balance of such design fees to be funded on a dollar for dollar basis as the hard construction costs are funded. Thereafter, each funded requisition for Landlord’s Contribution shall be
applied first on account of any hard construction costs and labor directly related to the Tenant’s Work and materials delivered to the Building in connection with the Tenant’s Work, and then, second on account of any design fees. If,
following the expiration of the six (6) month period following the completion of the Tenant’s Work and satisfaction of the conditions set forth in this Section, any amount of Landlord’s Contribution has not been requisitioned by
Tenant, such remainder shall be retained by Landlord and Tenant shall have no further right to claim thereto. 

  
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 (c) Landlord shall make progress payments on account of Landlord’s Contribution to
Tenant on a monthly basis, for the work performed during the previous month, less such retainage (“Retainage”) as is provided for in Tenant’s construction contract(s) and contracts for the purchase and delivery of
furniture, fixtures and equipment, provided that such contracts shall require Retainage of not less than five percent (5%) of the total contract price (in the aggregate) (which 5% Retainage shall not be in addition to the amounts retained under
such contracts). 
 (d) Landlord shall pay Landlord’s Proportion (hereinafter defined) of the cost shown on each requisition
submitted by Tenant to Landlord until the entirety of Landlord’s Contribution has been exhausted. “Landlord’s Proportion” shall be a fraction, the numerator of which is Landlord’s Contribution and the
denominator of which is the total contract price for Tenant’s Work (as evidenced by reasonably detailed documentation delivered to Landlord with the requisition first submitted by Tenant). 

Landlord’s progress payments shall be made payable directly to Tenant or, upon Tenant’s written request, to Tenant’s general
contractor, within thirty (30) days following the delivery to Landlord of requisitions therefor. Landlord shall have the right, upon reasonable advance notice to Tenant, to inspect Tenant’s books and records relating to each requisition in
order to verify the amount thereof. Tenant shall submit requisition(s) no more often than monthly. Each such requisition shall be executed by a duly authorized officer of Tenant, and shall be accompanied by (i) with the exception of the first
requisition, copies of partial waivers of lien from all contractors, subcontractors, and material suppliers covering all work and materials which were the subject of previous progress payments by Landlord and Tenant, (ii) a certification from
Tenant’s architect on a completed AIA Form G702, and (iii) a requisition certificate on a completed AIA Form G703. Landlord shall hold such Retainage and disburse the Retainage, or portions thereof as requisitioned by Tenant from time to
time on account of subcontractors who have completed their respective portions of the job, upon submission by Tenant to Landlord of Tenant’s requisition therefor accompanied by all documentation required under the foregoing provisions of this
Section, together with (A) proof of the satisfactory completion of all required inspections and issuance of any required approvals, permits and sign offs for the work of such subcontractor, or with respect to the work of the Tenant’s
general contractor, the Tenant’s Work, by Governmental Authorities having jurisdiction thereover (including issuance of the Certificate of Occupancy) (“Substantial Completion of Tenant’s Work”), and
(B) issuance of final lien waivers by all contractors, subcontractors and material suppliers covering all of the Tenant’s Work or the portion thereof as applicable (which final lien waivers may be conditioned upon, or delivered concurrent
with, payment of such Retainage). If Tenant fails to pay to Tenant’s contractors the amounts paid by Landlord to Tenant in connection with any previous requisition(s), Landlord shall thereafter have the right to have Landlord’s
Contribution paid directly to Tenant’s contractors. In addition, concurrent with the final requisition for the Retainage, Tenant shall submit “as-built” plans and specifications for the Tenant’s Work. The right to receive
Landlord’s Contribution is for the exclusive benefit of Tenant, and in no event shall such right be assigned to or be enforceable by or for the benefit of any third party, including any contractor, subcontractor, materialman, laborer,
architect, engineer, attorney or other person or entity (excepting only to a permitted assignee of this Lease pursuant to Article 17). 

  
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 ARTICLE 6 

USE 
 6.1
Use. The Premises shall be used solely for the Permitted Use set forth in the basic lease provisions in Section 1.1 of this Lease, and in compliance with all Legal Requirements now or hereafter applicable to the
Premises, and to the use and occupancy thereof, including, without limitation, the Americans With Disabilities Act, 42 U.S.C. § 12101, et seq. (together with the regulations promulgated pursuant thereto, “ADA”). Tenant
shall, upon 5 days’ written notice from Landlord, discontinue any use of the Premises which is declared by any Governmental Authority (as defined in Section 4.6) having jurisdiction to be a violation of a Legal Requirement.
Tenant will not use or permit the Premises to be used for any purpose or in any manner that would void Tenant’s or Landlord’s insurance, increase the insurance cost, or cause the disallowance of any sprinkler or other credits. Tenant shall
reimburse Landlord promptly upon demand for any additional premium charged for any such insurance policy by reason of Tenant’s failure to comply with the provisions of this Section or otherwise caused by Tenant’s use and/or occupancy of
the Premises. Tenant will use the Premises in a careful, safe and proper manner and will not commit or permit waste, overload the floor or structure of the Premises, subject the Premises to use that would damage the Premises or obstruct or interfere
with the rights of Landlord or other tenants or occupants of the Project, including conducting or giving notice of any auction, liquidation, or going out of business sale on the Premises, or using or allowing the Premises to be used for any unlawful
purpose. Tenant shall cause any equipment or machinery to be installed in the Premises so as to reasonably prevent sounds or vibrations from the Premises from extending into Common Areas, or other space in the Project. Tenant shall not, without the
prior written consent of Landlord use the Premises in any manner which will require ventilation, air exchange, heating, gas, steam, electricity or water beyond the capacity of the Project as set forth in this Lease. 

Tenant, at its sole expense, shall make any alterations or modifications to the interior or the exterior of the Premises or the Project that
are required by Legal Requirements (including, without limitation, compliance of the Premises with the ADA) related to Tenant’s use or occupancy of the Premises. Notwithstanding any other provision herein to the contrary, Tenant shall be
responsible for any and all demands, claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses incurred in investigating or resisting the same (including, without limitation,
reasonable attorneys’ fees, charges and disbursements and costs of suit) (collectively, “Claims”) arising out of or in connection with Legal Requirements related to Tenant’s use or occupancy of the Premises, and
Tenant shall indemnify, defend, hold and save Landlord harmless from and against any and all Claims arising out of or in connection with any failure of the Premises to comply with any Legal Requirement (to the extent that such Claims do not arise
from the failure of Landlord’s Work to comply with any Legal Requirements). 
 ARTICLE 7 

PARKING 
 7.1
Parking. Subject to all matters of record, Force Majeure, a Taking and the exercise by Landlord of its rights hereunder, Tenant shall have the right, in common with other tenants of the Project to use Tenant’s pro rata share of the
non-reserved parking spaces at the Project at the then-current prevailing rate equal to (a) .65 parking spaces per 1,000 rentable square feet of the Premises (or 28 spaces based on 43,586 RSF) for the parking spaces located in the Building
garage 

  
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at the current monthly fee of $225 per space, and (b) .35 parking spaces per 1,000 rentable square feet of the Premises (or 15 spaces based on 43,586 RSF) for surface parking spaces located
on the adjacent lot at the current monthly fee of $175 per space, as such rates may vary from time to time to reflect current fair market parking rates in East Cambridge and Kendall Square, as shown on the parking plan attached hereto as
EXHIBIT I (“Parking Plan”). Subject to Landlord’s reasonable requirements or conditions and any applicable Legal Requirements and the rights of Foundation Medicine, Inc. and its successors and assigns
(“Foundation Medicine”), Tenant may designate and mark (by virtue of signage reasonably approved by Landlord) at Tenant’s cost a portion of Tenant’s allocated parking spaces for visitor parking on a reserved basis
in locations to be reasonably agreed upon by Landlord and Tenant. 
 The parking spaces shall be subject to such reasonable rules and
regulations as may be in effect for the use of the parking garage/areas from time to time (including, without limitation, Landlord’s right, without additional charge to Tenant above the prevailing fair market rate for parking spaces, to
institute a valet or attendant-managed parking system) provided that access to the parking spaces by Tenant’s employees shall be on a 24/7 basis. Landlord shall not be liable to Tenant, and this Lease shall not be affected, if any parking
rights of Tenant hereunder are impaired by Applicable Law. Notwithstanding anything to the contrary contained herein, Landlord shall have the right to relocate the surface parking spaces to the following garages in order of priority: (1) the
CambridgeSide Galleria Parking Garage located at 100 CambridgeSide Place in Cambridge; (2) the First Street Garage located on Spring Street in Cambridge; and (3) the common parking facility that serves the buildings located at 350
Kendall Street, 650 East Kendall Street, 675 West Kendall Street, 500 Kendall Street and 350 3rd Street (Watermark Cambridge), each located in Cambridge. If parking spaces are not available in
such garages, then Landlord shall have the right to relocate the surface parking spaces to an alternate public parking facility of comparable quality located no further than one third mile from the Project and located within the City of Cambridge.
Tenant shall be responsible for the actual fee for such offsite parking spaces which fee shall not to exceed the published parking rates for monthly parking for the respective parking garage from time to time and shall not include any mark-up of
such fee by Landlord or the owner or operator of the parking garage. 
 Within thirty (30) days after the Effective Date and each
anniversary of the Lease Commencement Date, Tenant shall provide Landlord written notice of the number of parking spaces allocated to Tenant that Tenant is committed to using each year. If the number of parking spaces requested by Tenant is less
than the 28 garage spaces and 15 surface spaces allocated to Tenant, then Landlord reserves the right to allocate the excess parking spaces to other occupants in the Building on monthly basis. Upon sixty (60) days notice from Tenant, Landlord
shall arrange for such reallocated parking spaces to be restored for Tenant’s non-exclusive use. 
 Tenant shall have no right to
hypothecate or encumber the parking spaces, and shall not sublet, assign, or otherwise transfer the parking spaces other than to employees of Tenant occupying the Premises or to a permitted transferee pursuant to Section 17 of this Lease. 

Tenant shall, at Tenant’s sole expense, for so long as the Parking and Traffic Demand Management Plan dated April 2008 as approved by the
City of Cambridge on April 28, 2008, including the conditions set forth in such approval (as amended from time to time, the “PTDM”), remains applicable to the Project, (i) offer to subsidize mass transit monthly
passes for all of its 

  
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employees; (ii) implement a Commuter Choice Program; (iii) discourage single-occupant vehicle use by its employees; (iv) promote alternative modes of transportation and use of
alternative work hours; (v) meet with Landlord and/or its representatives no more than quarterly to discuss transportation programs and initiatives; (vi) participate in annual surveys monitoring transportation programs and initiatives;
(vii) cooperate with Landlord in connection with transportation programs and initiatives promulgated pursuant to the PTDM; (viii) provide alternative work programs (such as telecommuting, flex-time and compressed work weeks) to its
employees in order to reduce traffic impacts in Cambridge during peak commuter hours; and (ix) otherwise cooperate with Landlord in encouraging employees to seek alternate modes of transportation. 

ARTICLE 8 
 UTILITIES;
SERVICES 
 8.1 Utilities; Services. Landlord shall provide, subject to the terms of this Section, hot and cold water
for restrooms, drinking and office kitchen purposes, sewer connection, heated and chilled water for the HVAC system serving the Premises, electricity in an amount at least equal to 12 watts per usable square foot, gas service for the HVAC system and
water for sprinklers (collectively, “Utilities”) as more particularly set forth in the Base Building Specifications. Landlord shall pay, as Operating Expenses or subject to Tenant’s reimbursement obligation, for all
Utilities used on the Premises, all maintenance charges for Utilities, and any storm sewer charges or other similar charges for Utilities imposed by any Governmental Authority or Utility provider, and any taxes, penalties, surcharges or similar
charges thereon. Utilities will be separately metered or charged directly to Tenant by the provider as provided in the Landlord/Tenant Matrix attached hereto as Exhibit F. Tenant shall pay directly to the Utility provider, prior to
delinquency, any separately metered Utilities and services which may be furnished to Tenant or the Premises during the Term. Tenant shall pay, as part of Operating Expenses, its share of all charges for jointly metered Utilities based upon
consumption, as reasonably determined by Landlord. No interruption or failure of Utilities, from any cause whatsoever other than Landlord’s negligence or willful misconduct, shall result in eviction or constructive eviction of Tenant,
termination of this Lease or the abatement of Rent. Tenant agrees to limit use of water and sewer with respect to Common Areas to normal restroom use. Tenant shall supply its own cleaning and rubbish removal service. Landlord at Landlord’s cost
shall supply a dumpster or compactor at the loading dock for Tenant’s use for the disposal of non-hazardous, non-controlled substances. 

8.2 Shafts and Risers. During the Term, Landlord grants to Tenant a non-exclusive license to use a portion (reasonably specified
by Landlord based on Tenant’s Plans and generally based on Tenant’s Share) of the Building risers and other Building communications pathways reasonably designated by Landlord (“Communications Pathways”) for the
installation, maintenance, operation, replacement and/or removal at Tenant’s sole expense of certain cables, conduits, innerducts and connecting hardware approved by Landlord (any such cables, conduits, innerducts and connecting hardware
installed within the Communications Pathways, as the same may be modified, altered or replaced during the Term, are collectively referred to herein as the “Connecting Cables”). Any such approvals shall be granted, and
installation performed, in accordance with the terms of Section 11 below. With respect to each cable placed in the Communications Pathways from and after the Execution Date, Tenant shall label such cable (at the floor of the Building where the
cable originates and the floor where such cable terminates and at 

  
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each access point in between at which such cable is pulled) with identification information as reasonably required by Landlord which shall be consistent with commercial practice in the
Cambridge/Kendall Square submarket. Landlord makes no warranties or representations to Tenant as to the suitability of the Communications Pathways for the installation and operation of the Connecting Cables and Tenant hereby accepts the same in
their as is, where is condition with all faults on the date hereof, provided, however, Landlord shall ensure that such Communications Pathways are dry and free of interference from electrical cables and other base building devices likely to
interfere with the operation of such Connecting Cables. In the event that at any time during the Term, Landlord reasonably determines, that the operation and/or periodic testing of the Connecting Cables interferes with the operation of the Building
or the business operations of any of the occupants of the Building, then Tenant shall, upon reasonable notice from Landlord attempt to correct such interference in accordance with commercially reasonable approaches. Tenant is expressly forbidden to
serve other tenants or occupants of the Building, to serve any locations outside the Building, or to resell any communications services without the prior written consent of Landlord, which consent may be granted in Landlord’s sole discretion.
Upon the expiration or earlier termination of this license, Tenant shall remove the Connecting Cables from the Communications Pathways and restore any damage to the Building related to the removal of the Connecting Cables caused by Tenant, which
obligations shall survive the expiration or earlier termination of this Lease. In addition, Landlord may, upon reasonable prior written notice (which notice shall not be required in the event of an emergency), suspend this license and/or relocate
the Connecting Cables in the event of any repair or construction affecting the Communications Pathways, provided, however, prior to making any such repair or construction, Landlord shall ensure that Tenant has an alternative means of communicating
in a manner consistent with the operation and standards of the Connecting Cables at the time of such license suspension and at Landlord’s sole cost and expense. After the completion of such repair and/or construction, this license shall be
reinstated with such reasonable modifications as Landlord may require and for which Landlord shall reimburse Tenant to ensure consistency with the new use of the Communications Pathways. Subject to earlier termination pursuant to the provisions of
this Section, this license shall be coterminous with the Lease. 
 8.3 Rooftop Premises. During the Term, Tenant shall have
the right to use a portion of the rooftop of the Building reasonably designated by Landlord (the “Rooftop Premises”) at no additional rental cost for the installation of HVAC equipment, antennas, satellite dishes or other
communications device and certain mechanical devices necessary for the operation of Tenant’s business in the Premises, all of which shall have been approved by Landlord (any devices and/or equipment installed within the Rooftop Premises, as the
same may be modified, altered or replaced during the Term, is collectively referred to herein as “Tenant’s Rooftop Equipment”). Landlord’s approval of such devices and/or equipment shall not be unreasonably
withheld, conditioned or delayed provided Tenant demonstrates to Landlord’s reasonable satisfaction that the proposed devices and/or equipment (i) do not interfere with any base building equipment operated by Landlord on the roof;
(ii) will not affect the structural integrity of the Building or void the warranty for the roof or the roof membrane; (iii) shall be adequately screened so as to minimize the visibility of such devices and/or equipment; and (iv) shall
be adequately sound-proofed to meet all requirements of Legal Requirements. Tenant shall not install or operate Tenant’s Rooftop Equipment until Tenant has obtained and submitted to Landlord copies of all required governmental permits,
licenses, and authorizations necessary for the installation and operation thereof. In addition, Tenant shall comply with all reasonable construction rules and regulations 

  
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promulgated by Landlord in connection with the installation, maintenance and operation of Tenant’s Rooftop Equipment. Landlord shall provide reasonable utility service (at Tenant’s
reasonable cost) to the Rooftop Premises or to Tenant’s Rooftop Equipment. Tenant shall be responsible for the cost of repairing and maintaining Tenant’s Rooftop Equipment in good order, condition and repair and for the cost of repairing
any damage to the Building, or the cost of any necessary improvements to the Building, caused by or as a result of the installation, replacement and/or removal of Tenant’s Rooftop Equipment. Landlord makes no warranties or representations to
Tenant as to the suitability of the Rooftop Premises for the installation and operation of Tenant’s Rooftop Equipment. Tenant shall use Landlord’s roof contractor (if such roof is under warranty by such contractor) or another contractor
reasonably acceptable to Landlord for any work impacting the roof or roof membrane. If Tenant’s Rooftop Equipment damages the roof (other than ordinary wear and tear damage or damage arising from extraordinary events of a nature not
controllable by Tenant such as high winds, fire, electrical storms and the like) or invalidates or adversely affects any warranty, Tenant shall be fully responsible for the cost of repairs directly related and limited to the damage caused by
Tenant’s Rooftop Equipment (and any subsequent repairs to the roof to the extent that any warranty is invalidated or adversely affected). Except as set forth in the next sentence, Landlord shall elect, at the time of Landlord’s approval
thereof, either to require Tenant to convey to Landlord, in consideration of Ten Dollars ($10.00), all of Tenant’s right, title and interest in and to all or any portion of Tenant’s Rooftop Equipment or to remove such Tenant’s Rooftop
Equipment or a portion thereof at the expiration or sooner termination of the Term. Notwithstanding the foregoing, unless this Lease has been terminated due to a Default by Tenant, Tenant may remove Tenant’s satellite dishes and generators and
equipment appurtenant thereto at the expiration of the Term at Tenant’s cost provided that Tenant complies with any reasonable requirements or conditions imposed by Landlord and that Tenant remains responsible for the cost of repairs directly
related and limited to the damage caused by the removal of such equipment. 
 8.4 Access. Subject to reasonable security
procedures that Landlord may institute from time to time to prevent unauthorized access to the Building, Tenant shall have access to the Premises, the Rooftop Premises, the Building garage and surface lot, the freight elevator and freight loading
dock, and any other appurtenant areas, twenty-four (24) hours per day, seven (7) days per week. A security card will be issued to all permitted Building occupants. An access card will be required for access to the Building between the
hours of 6:00 p.m. and 7:00 a.m. on weekdays and 24 hours a day on weekends. Landlord shall install a card key access system on the elevators providing Tenant with the ability to lock off any full floors that it occupies. 

ARTICLE 9  

ALTERATIONS 
 9.1
Alterations and Tenant’s Property. Any alterations, additions, or improvements made to the Premises by or on behalf of Tenant, including additional locks or bolts of any kind or nature upon any doors or windows in the
Premises, but excluding installation, removal or realignment of furniture systems (other than removal of furniture systems owned or paid for by Landlord) not involving any modifications to the structure or connections (other than by ordinary plugs
or jacks) to Building Systems (as defined in Section 10.1) (“Alterations”), shall be subject to Landlord’s prior written consent, which may be given or withheld in Landlord’s sole discretion if
any such Alteration affects the structure or Building Systems and shall not be otherwise unreasonably withheld, conditioned or delayed. If Landlord approves any Alterations, Landlord 

  
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may impose such reasonable conditions on Tenant in connection with the commencement, performance and completion of such Alterations as Landlord may deem appropriate in Landlord’s sole and
absolute discretion. However, Landlord’s consent shall not be required for any Alterations that (a) are not visible from the exterior of the Building; (b) will not adversely affect the Building Systems or structural elements; and
(c) either are of a cosmetic nature such as painting, wallpapering, hanging pictures and installing carpeting, or cost less than $50,000 in any one instance. Any request for approval shall be in writing, delivered not less than 15 Business Days
in advance of any proposed construction, and accompanied by plans, specifications, bid proposals, work contracts and such other information concerning the nature and cost of the alterations as may be reasonably requested by Landlord, including the
identities and mailing addresses of all persons performing work or supplying materials. Landlord’s right to review plans and specifications and to monitor construction shall be solely for its own benefit, and Landlord shall have no duty to
ensure that such plans and specifications or construction comply with applicable Legal Requirements. Tenant shall cause, at its sole cost and expense, all Alterations to comply with insurance requirements and with Legal Requirements and shall
implement at its sole cost and expense any alteration or modification required by Legal Requirements as a result of any Alterations. Landlord shall not charge Tenant any coordination, overhead or contractor supervision fees in connection with the
Alterations; provided, however that Landlord shall be reimbursed for any reasonable third-party, out of pocket expenses incurred by Landlord in connection with the review and approval of the Alterations. Before Tenant begins any Alteration, Landlord
may post on and about the Premises notices of non-responsibility pursuant to applicable law. Tenant shall reimburse Landlord for, and indemnify and hold Landlord harmless from, any expense incurred by Landlord by reason of faulty work done by Tenant
or its contractors, delays caused by such work, or inadequate cleanup. The construction of Tenant’s Work shall be governed by the provisions contained in Section 5.2, and not the provisions of this Article 9. 

Upon Landlord’s request, Tenant shall furnish security or make other arrangements satisfactory to Landlord to assure payment for the
completion of all Alterations work free and clear of liens, and shall provide (and cause each contractor or subcontractor to provide) certificates of insurance for workers’ compensation and other coverage in amounts and from an insurance
company satisfactory to Landlord protecting Landlord against liability for personal injury or property damage during construction. Upon completion of any Alterations, Tenant shall deliver to Landlord: (i) sworn statements setting forth the
names of all contractors and subcontractors who did the work and final lien waivers from all such contractors and subcontractors; and (ii) “as built” plans for any such Alteration. 

Except for Removable Installations (as hereinafter defined), all Installations (as hereinafter defined) shall be and shall remain the property
of Landlord during the Term and following the expiration or earlier termination of the Term, shall not be removed by Tenant at any time during the Term, and shall remain upon and be surrendered with the Premises as a part thereof. Notwithstanding
the foregoing, Landlord may, at the time its approval of any such Installation is requested, notify Tenant that Landlord requires that Tenant remove such Installation upon the expiration or earlier termination of the Term, in which event Tenant
shall remove such Installation in accordance with the immediately succeeding sentence. Upon the expiration or earlier termination of the Term, Tenant shall remove (i) Connecting Cable as required in Section 8.2, (ii) any Installations
for which Landlord has given Tenant notice of removal in accordance with the immediately preceding sentence, and (iii) all of Tenant’s Property (as hereinafter defined), and 

  
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Tenant shall restore and repair any damage caused by or occasioned as a result of such removal, including, without limitation, capping off all such connections behind the walls of the Premises
and repairing any holes. During any restoration period beyond the expiration or earlier termination of the Term, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant. Landlord hereby waives any lien
or other interest in any of Tenant’s Property and Removable Installations and shall confirm such waiver in a form reasonably acceptable to Landlord and Tenant provided that Landlord shall be paid for Landlord’s reasonable out of pocket
expenses in connection with the waiver process. 
 For purposes of this Lease, (x) “Removable Installations”
means any Installations that Tenant desires to have removed from the Premises at the expiration or earlier termination of the Term which Landlord agrees in writing may be removed by Tenant, (y) “Tenant’s Property”
means Removable Installations and, other than Installations, any personal property or equipment of Tenant that may be removed without material damage to the Premises, and (z) “Installations” means all property of any
kind paid for by Landlord, all Alterations, all fixtures, and all partitions, hardware, built-in machinery, built-in casework and cabinets and other similar additions, equipment, property and improvements built into the Premises so as to become an
integral part of the Premises, including, without limitation, fume hoods which penetrate the roof or plenum area, built-in cold rooms, built-in warm rooms, walk-in cold rooms, walk-in warm rooms, deionized water systems, glass washing equipment,
autoclaves, chillers, built-in plumbing, electrical and mechanical equipment and systems, and any power generator and transfer switch. 

ARTICLE 10  

REPAIRS AND MAINTENANCE 

10.1 Landlord’s Repairs. Landlord, as an Operating Expense subject to the provisions of Section 4.5 hereof,
shall maintain all of the structural, exterior, parking and other Common Areas of the Project, including roof, HVAC, plumbing, fire sprinklers, elevators and all other building systems serving the Premises and other portions of the Project
(“Building Systems”), in good repair, comparable to other first class lab research buildings in the Kendall Square area and in compliance with all applicable Legal Requirements, reasonable wear and tear and uninsured losses
and damages and damage caused by Tenant, or by any of Tenant’s agents, servants, employees, invitees and contractors (collectively, “Tenant Parties”) excluded. Losses and damages caused by Tenant or any Tenant Party
shall be repaired by Landlord, to the extent not covered by insurance, at Tenant’s sole cost and expense. Landlord reserves the right to stop Building Systems services when necessary (i) by reason of accident or emergency, or (ii) for
planned repairs, alterations or improvements, which are, in the judgment of Landlord, desirable or necessary to be made, until said repairs, alterations or improvements shall have been completed. Landlord shall have no responsibility or liability
for failure to supply Building Systems services during any such period of interruption; provided, however, that Landlord shall, except in case of emergency, give Tenant 24 hours advance notice of any planned stoppage of Building
Systems services for routine maintenance, repairs, alterations or improvements. Tenant shall promptly give Landlord written notice of any repair required by Landlord pursuant to this Section, after which Landlord shall make a commercially reasonable
effort to effect such repair. Landlord shall not be liable for any failure to make any repairs or to perform any maintenance unless such failure shall persist for an unreasonable time after Tenant’s written notice of the need for such repairs
or maintenance but in no event not later than thirty (30) days after receipt of such notice, or such longer time as is 

  
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reasonably necessary if more than 30 days are reasonably required to complete such repairs so long as Landlord commences such repairs within such 30 day period and thereafter diligently attempts
to complete the same. Tenant waives its rights under any state or local law to terminate this Lease or to make such repairs at Landlord’s expense and agrees that the parties’ respective rights with respect to such matters shall be solely
as set forth herein. Repairs required as the result of fire, earthquake, flood, vandalism, war, or similar cause of damage or destruction shall be controlled by Section 14.1. 

10.2 Tenant’s Repairs. Subject to Section 10.1 hereof, Tenant, at its expense, shall repair, replace and
maintain in good condition all portions of the Premises, including, without limitation, entries, doors, ceilings, interior windows, interior walls, and the interior side of demising walls, reasonable wear and tear and damage by fire or other
casualty excepted. Such repair and replacement may include capital expenditures and repairs whose benefit may extend beyond the Term. Should Tenant fail to make any such repair or replacement or fail to maintain the Premises, Landlord shall give
Tenant notice of such failure. If Tenant fails to commence cure of such failure within 30 days of Landlord’s notice, and thereafter diligently prosecute such cure to completion, Landlord may perform such work and shall be reimbursed by Tenant
within 30 days after demand therefor; provided, however, that if such failure by Tenant creates or could create an emergency, Landlord may immediately commence cure of such failure and shall thereafter be entitled to recover the costs of such cure
from Tenant. Subject to Articles 13 and 14, Tenant shall bear the full uninsured cost of any repair or replacement to any part of the Project that results from damage caused by Tenant or any Tenant Party and any repair that benefits only the
Premises. 
 ARTICLE 11 

MECHANIC’S LIENS 

11.1 Mechanic’s Liens. Tenant shall discharge, by bond or otherwise, any mechanic’s lien filed against the Premises or
against the Project for work claimed to have been done for, or materials claimed to have been furnished to, Tenant within 10 Business Days after written notice of the filing thereof, at Tenant’s sole cost and shall otherwise keep the Premises
and the Project free from any liens arising out of work performed, materials furnished or obligations incurred by Tenant. Should Tenant fail to discharge any lien described herein, Landlord shall have the right, but not the obligation, to pay such
claim or post a bond or otherwise provide security to eliminate the lien as a claim against title to the Project and the cost thereof shall be immediately due from Tenant as Additional Rent. If Tenant shall lease or finance the acquisition of office
equipment, furnishings, or other personal property of a removable nature utilized by Tenant in the operation of Tenant’s business, Tenant warrants that any Uniform Commercial Code Financing Statement filed as a matter of public record by any
lessor or creditor of Tenant will upon its face or by exhibit thereto indicate that such Financing Statement is applicable only to removable personal property of Tenant located within the Premises. In no event shall the address of the Project be
furnished on the statement without qualifying language as to applicability of the lien only to removable personal property, located in an identified suite held by Tenant. 

  
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 ARTICLE 12 

INDEMNIFICATION 

12.1 Indemnification. Tenant hereby indemnifies and agrees to defend, save and hold Landlord harmless from and against any and
all demands, claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses incurred in investigating or resisting the same (including, without limitation, reasonable attorneys’ fees,
charges and disbursements and costs of suit) (collectively, “Claims”) for injury or death to persons or damage to property (a) occurring within the Premises, or (b) occurring outside of the Premises and caused by
the negligence or willful misconduct of Tenant, or (c) arising from a breach or default by Tenant in the performance of any of its obligations hereunder, in all cases unless caused solely by the willful misconduct or negligence of Landlord or
Landlord’s agents, servants, employees, and contractors. Landlord shall not be liable to Tenant for, and Tenant assumes all risk of damage to, personal property (including, without limitation, loss of records kept within the Premises), unless
caused solely by the willful misconduct or negligence of Landlord or Landlord’s agents, servants, employees, and contractors, but subject to waiver of claims and subrogation provisions of Article 13. Tenant further hereby irrevocably waives any
and all Claims for injury to Tenant’s business or loss of income relating to any such damage or destruction of personal property (including, without limitation, any loss of records). Landlord shall not be liable for any damages arising from any
act, omission or neglect of any tenant in the Project or of any other third party. 
 The provisions of this Section 12.1 shall survive
the expiration or earlier termination of this Lease. 
 ARTICLE 13 

INSURANCE 
 13.1
Insurance. (a) Tenant shall not conduct or permit to be conducted any activity, or place any equipment in or about the Premises or the Building which will in any way increase the rate of fire insurance or other insurance on the
Building pertaining to the Permitted Use in compliance with the terms of the Lease provided that the Hazardous Materials List (defined in Section 21.2) does not change. If any increase in the rate of fire insurance or other insurance is stated
by any insurance company to be due to any activity or equipment of Tenant in or about the Premises or the Building, such statement shall be conclusive evidence that the increase in such rate is due to such activity or equipment and, as a result
thereof, Tenant shall be liable for the amount of such increase. Tenant shall reimburse Landlord for such amount upon written demand from Landlord and such sum shall be considered additional rent payable hereunder.

(b) Landlord shall insure the Building, other than Tenant’s Work and Alterations (including improvements and betterments which
shall be Tenant’s obligation to insure), against loss due to fire and other casualties included in standard extended coverage insurance policies in an amount equal to ninety percent (90%) of the replacement cost thereof (with a waiver of
co-insurance), exclusive of architectural and engineering fees, excavations, footings and foundations. Throughout the Lease Term, Landlord shall maintain commercial general liability insurance (written on an occurrence basis) covering the
Project. Such insurance shall need not cover (a) Tenant’s furniture, fixtures, equipment or other personal property of Tenant on the Premises, or (b) any portion of the Tenant’s Work.

  
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 (c) Commencing on the Lease Commencement Date and throughout the Lease Term, Tenant shall
obtain and maintain (1) commercial general liability insurance (written on an occurrence basis) including coverage provided in the current Insurance Services Office commercial general liability policy form insuring the indemnification
obligations assumed by Tenant under this lease to the extent they are insurable, premises and operations coverage, containing an endorsement for personal injury, (2) all-risk property insurance, or its equivalent (with flood and earthquake
coverage at Tenant’s option), (3) business interruption insurance (in an amount not less than the Base Rent and Additional Rent then in effect during any year), (4) comprehensive automobile liability insurance (covering any
automobiles owned or operated by Tenant, if any), (5) worker’s compensation insurance, (6) during all periods alcoholic beverages are dispensed or sold by Tenant at the Building or the Premises, liquor liability insurance or host
liquor liability insurance as the case may be, (7) employer’s liability insurance, and (8) such additional insurance relating to Tenant’s use and storage of Hazardous Materials as may be necessary to comply with any requirement
of any Governmental Authority. Such commercial general liability insurance shall be in an amount (which may include umbrella liability insurance) of no less than Two Million Dollars ($2,000,000) combined single limit per occurrence with a Three
Million Dollar ($3,000,000) annual aggregate. Such property insurance shall be in an amount not less than that required to replace all of Tenant’s Work and Alterations (including improvements and betterments) and all other contents of the
Tenant on the Premises (including, without limitation, Tenant’s trade fixtures, decorations, furnishings, equipment and personal property). Such automobile liability insurance shall be in an amount not less than One Million Dollars
($1,000,000) for each accident. Such worker’s compensation insurance shall carry minimum limits as defined by the law of the jurisdiction in which the Building is located (as the same may be amended from time to time). Such
employer’s liability insurance shall be in an amount not less than Five Hundred Thousand Dollars ($500,000) for each accident, Five Hundred Thousand Dollars ($500,000) disease-policy limit, and Five Hundred Thousand Dollars ($500,000)
disease-each employee.
 (d) All such insurance required of Tenant under this Section shall: (1) be issued by a company
that is licensed to do business in the jurisdiction in which the Building is located and that has a rating equal to or exceeding A:VII from Best’s Insurance Guide; (2) in the case of the commercial general liability insurance, name as
additional insureds, the Landlord and the Landlord’s managing agent of the Building and if required by Landlord’s lender, the holder of any mortgage will be added as additional insured upon request by Landlord; (3) in the case of the
all-risk property insurance and business interruption insurance, provide that the insurer thereunder waives all right of recovery by way of subrogation against Landlord, its partners, employees and mortgage holder where required in writing prior to
a loss, in connection with any loss or damage covered by Tenant’s property policy; (4) be reasonably acceptable in form and content to Landlord if not on customary industry form and content; (5) be primary and noncontributory;
(6) to the extent obtainable, tenant’s insurer will endeavor to provide to Landlord, 30 days prior written notice of cancellation (with an exception of 10 days for non-payment of premium); however Tenant agrees to provide notice to
Landlord as soon as they are aware of such cancellation from their carriers; and (7) not contain any deductible provision that is not commercially reasonable unless such provision is first approved in writing by Landlord (provided that
Tenant’s deductible of $25,000 as of the Effective Date is deemed approved). Landlord may, from time to time, require Tenant to obtain additional insurance if such request is reasonable and customary with insurance requirements of other similar
tenants in the same geographic region, or if Landlord’s Lender requires a change to comply with loan requirements. Tenant shall provide certificates of insurance evidencing all required coverage prior to commencement of Tenant’s Work and
annually during the term of the lease prior to each policy expiration. Tenant shall also agree to provide full copies of actual policies upon written request from Landlord. Landlord may defer commencement of the Tenant’s Work pending delivery
of evidence of insurance. 

  
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 (e) Tenant hereby waives and releases Landlord and the holder of any mortgage from any and
all liabilities, claims and losses for damage to property for which Landlord is or may otherwise be held liable to the extent Tenant either is required to maintain property insurance pursuant to this Article with respect to the property so damaged,
or receives insurance proceeds on account thereof. Landlord hereby waives and releases Tenant from any and all liabilities, claims and losses for damage to property for which Tenant is or may be otherwise held liable to the extent Landlord either is
required to maintain property insurance pursuant to this Article with respect to the property so damaged, or receives insurance proceeds on account thereof. In the case of the all-risk property insurance, both parties shall secure waiver of
subrogation endorsements from their respective insurance carriers as to the other party. 
 ARTICLE 14 

RESTORATION 

14.1 Restoration. If, at any time during the Term, the Project or the Premises are damaged or destroyed by a fire or other
insured casualty, Landlord shall notify Tenant within 30 days after discovery of such damage as to the amount of time Landlord reasonably estimates it will take to restore the Project or the Premises, as applicable (the “Restoration
Period”). If the Restoration Period is reasonably estimated to exceed 9 months (the “Maximum Restoration Period”), Landlord may, in such notice, elect to terminate this Lease as of the date that is 45 days after
the date of discovery of such damage or destruction. If Landlord, in such notice, does not elect to terminate this Lease, and the restoration will exceed the Maximum Restoration period, Tenant may terminate this Lease by providing Landlord with
notice of such election to terminate this Lease within five (5) Business Days of Tenant’s receipt of such notice. Unless Landlord or Tenant, as the case may be, so elects to terminate this Lease, Landlord shall, subject to receipt of
sufficient insurance proceeds (with any deductible to be treated as a current Operating Expense), promptly restore the Premises (including Landlord’s Work and Tenant’s Work, but excluding the improvements installed by Tenant or by Landlord
and paid for by Tenant), subject to delays arising from the collection of insurance proceeds, from Force Majeure events or as needed to obtain any license, clearance or other authorization of any kind required to enter into and restore the Premises
issued by any Governmental Authority having jurisdiction over the use, storage, handling, treatment, generation, release, disposal, removal or remediation of Hazardous Materials in, on or about the Premises (collectively referred to herein as
“Hazardous Materials Clearances”); provided, however, that if repair or restoration of the Premises is not substantially complete as of the end of the Maximum Restoration Period or, if longer, the Restoration Period, Landlord
may, in its sole and absolute discretion, elect not to proceed with such repair and restoration, in which event Landlord shall be relieved of its obligation to make such repairs or restoration and this Lease shall terminate as of the date that is 75
days after the later of: (i) discovery of such damage or destruction, or (ii) the date all required Hazardous Materials Clearances are obtained, but Landlord shall retain any Rent paid and the right to any Rent payable by Tenant prior to
such election by Landlord. 

  
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 Tenant, at its expense, shall promptly perform, subject to delays arising from the collection of
insurance proceeds, from Force Majeure (as defined in Section 30.20) events or to obtain Hazardous Material Clearances, all repairs or restoration not required to be done by Landlord and shall promptly re-enter the Premises and commence
doing business in accordance with this Lease. 
 Notwithstanding the foregoing, either party may terminate this Lease if the Premises are
damaged during the last year of the Term and Landlord reasonably estimates that it will take more than two months to repair such damage, or if insurance proceeds are not available for such restoration. Rent shall be abated from the date all required
Hazardous Material Clearances are obtained until the Premises are repaired and restored, in the proportion which the area of the Premises, if any, which is not usable by Tenant bears to the total area of the Premises, unless Landlord provides Tenant
with other space during the period of repair that is suitable for the temporary conduct of Tenant’s business. Such abatement shall be the sole remedy of Tenant, and except as provided in this Section, Tenant waives any right to terminate the
Lease by reason of damage or casualty loss. 
 The provisions of this Lease, including this Section, constitute an express agreement between
Landlord and Tenant with respect to any and all damage to, or destruction of, all or any part of the Premises, or any other portion of the Project, and any statute or regulation which is now or may hereafter be in effect shall have no application to
this Lease or any damage or destruction to all or any part of the Premises or any other portion of the Project, the parties hereto expressly agreeing that this Section sets forth their entire understanding and agreement with respect to such matters.

 ARTICLE 15 

CONDEMNATION 

15.1 Condemnation. If the whole or any material part of the Premises or the Project is taken for any public or quasi-public use
under governmental law, ordinance, or regulation, or by right of eminent domain, or by private purchase in lieu thereof (a “Taking” or “Taken”), and the Taking would in Landlord’s reasonable
judgment, either prevent or materially interfere with Tenant’s use of the Premises or materially interfere with or impair Landlord’s ownership or operation of the Project, then upon written notice by Landlord this Lease shall terminate and
Rent shall be apportioned as of said date. In addition, if a Taking of the whole or any material part of the Premises or the Project would in the reasonable judgment of Tenant either prevent or materially interfere with Tenant’s use of the
Premises, Tenant shall have the right to terminate this Lease by written notice to Landlord within thirty (30) days of the date that Landlord’s title has been divested of such property. If part of the Premises shall be Taken, and this
Lease is not terminated as provided above, Landlord shall promptly restore the Premises and the Project as nearly as is commercially reasonable under the circumstances to their condition prior to such partial Taking and the rentable square footage
of the Building, the rentable square footage of the Premises, Tenant’s Share of Operating Expenses and the Rent payable hereunder during the unexpired Term shall be reduced to such extent as may be fair and reasonable under the circumstances.
Upon any such Taking, Landlord shall be entitled to receive the entire price or award from any such Taking without any payment to Tenant, and Tenant hereby assigns to Landlord Tenant’s interest, if any, in such award. Tenant shall have the
right, to the extent that same shall not diminish Landlord’s award, to make a separate claim against the condemning authority (but not Landlord) for such 

  
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compensation as may be separately awarded or recoverable by Tenant for moving expenses and damage to Tenant’s trade fixtures, if a separate award for such items is made to Tenant. Tenant
hereby waives any and all rights it might otherwise have pursuant to any provision of state law to terminate this Lease upon a partial Taking of the Premises or the Project. 

ARTICLE 16 
 EVENTS OF
DEFAULT 
 16.1 Events of Default. Each of the following events shall be a default (“Default”)
by Tenant under this Lease: 
 (a) Payment Defaults. Tenant shall fail to pay any installment of Rent or any other payment
hereunder when due and such default shall continue for more than five (5) Business Days after written notice from Landlord. 
 (b)
Insurance. Any insurance required to be maintained by Tenant pursuant to this Lease shall be canceled or terminated or shall expire or shall be reduced or materially changed, or Landlord shall receive a notice of nonrenewal of any such
insurance and Tenant shall fail to replace such insurance at least 20 days before the expiration of the current coverage. 
 (c)
Abandonment. Tenant shall no longer conduct any of its business operations in the Premises. 
 (d) Improper
Transfer. Tenant shall assign, sublease or otherwise transfer all or any portion of Tenant’s interest in this Lease or the Premises except as expressly permitted herein, or Tenant’s interest in this Lease shall be attached,
executed upon, or otherwise judicially seized and such action is not released within 90 days of the action. 
 (e) Liens.
Tenant shall fail to discharge or otherwise obtain the release of any lien placed upon the Premises in violation of this Lease within 15 days after written notice from Landlord. 

(f) Insolvency Events. Tenant or any guarantor or surety of Tenant’s obligations hereunder shall: (A) make a general
assignment for the benefit of creditors; (B) commence any case, proceeding or other action seeking to have an order for relief entered on its behalf as a debtor or to adjudicate it a bankrupt or insolvent, or seeking reorganization,
arrangement, adjustment, liquidation, dissolution or composition of it or its debts or seeking appointment of a receiver, trustee, custodian or other similar official for it or for all or of any substantial part of its property (collectively a
“Proceeding for Relief”); (C) become the subject of any Proceeding for Relief which is not dismissed within 90 days of its filing or entry; or (D) die or suffer a legal disability (if Tenant, guarantor, or surety is
an individual) or be dissolved or otherwise fail to maintain its legal existence (if Tenant, guarantor or surety is a corporation, partnership or other entity). 

(g) Estoppel Certificate or Subordination Agreement. Tenant fails to execute any document required from Tenant under Article 18
or 19 within 5 Business Days after a second notice requesting such document. 

  
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 (h) Other Defaults. Tenant shall fail to comply with any provision of this Lease
other than those specifically referred to in this Section, and, except as otherwise expressly provided herein, such failure shall continue for a period of 30 days after written notice thereof from Landlord to Tenant. 

Any notice given pursuant to this Section hereof shall: (i) specify the alleged default, (ii) demand that Tenant cure such default,
(iii) be in lieu of, and not in addition to, or shall be deemed to be, any notice required under any provision of applicable law, and (iv) not be deemed a forfeiture or a termination of this Lease unless Landlord elects otherwise in such
notice; provided that if the nature of Tenant’s default pursuant to this Section is such that it cannot be cured by the payment of money and reasonably requires more than 30 days to cure, then Tenant shall not be deemed to be in default if
Tenant commences such cure within said 30 day period and thereafter diligently prosecutes the same to completion; provided, however, that such cure shall be completed no later than 90 days from the date of Landlord’s notice. 

16.2 Landlord’s Remedies. 

(a) Payment By Landlord; Interest. Upon a Default by Tenant hereunder, Landlord may, without waiving or releasing any obligation
of Tenant hereunder, make such payment or perform such act. All sums so paid or incurred by Landlord, together with interest thereon, from the date such sums were paid or incurred, at the Default Rate, shall be payable to Landlord on demand as
Additional Rent. 
 (b) Late Payment Rent. Late payment by Tenant to Landlord of Rent and other sums due will cause Landlord
to incur costs not contemplated by this Lease, the exact amount of which will be extremely difficult and impracticable to ascertain. Such costs include, but are not limited to, processing and accounting charges and late charges which may be imposed
on Landlord under any Mortgage covering the Premises. Therefore, if any installment of Rent due from Tenant is not received by Landlord within 5 days after the date such payment is due, Tenant shall pay to Landlord an additional sum equal to 5% of
the overdue Rent as a late charge. The parties agree that this late charge represents a fair and reasonable estimate of the costs Landlord will incur by reason of late payment by Tenant. In addition to the late charge, Rent not paid when due shall
bear interest at the Default Rate from the 5th day after the date due until paid. 
 (c) Remedies. Upon the occurrence of a
Default, Landlord, at its option, without further notice or demand to Tenant, shall have in addition to all other rights and remedies provided in this Lease, at law or in equity, the option to pursue any one or more of the following remedies, each
and all of which shall be cumulative and nonexclusive, without any notice or demand whatsoever. 
 (i) Terminate this
Lease, or at Landlord’s option, Tenant’s right to possession only, in which event Tenant shall immediately surrender the Premises to Landlord, and if Tenant fails to do so, Landlord may, without prejudice to any other remedy which it may
have for possession or arrearages in rent, enter upon and take possession of the Premises in compliance with applicable Legal Requirements and expel or remove Tenant and any other person who may be occupying the Premises or any part thereof, without
being liable for prosecution or any claim for damages therefor unless such process is accomplished by Landlord in violation of applicable Legal Requirements; 

  
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 (ii) Upon any termination of this Lease, whether pursuant to the foregoing
subsection (i) or otherwise, Landlord may recover from Tenant the following: 
 (A) The worth at the time of
award of any unpaid Rent which has been earned at the time of such termination; plus 
 (B) The worth at the time of
award of the amount by which the unpaid Rent which would have been earned after termination until the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 

(C) The worth at the time of award of the amount by which the unpaid Rent for the balance of the Term after the time of
award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 
 (D) Any
other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its obligations under this Lease or which in the ordinary course of things would be likely to result therefrom, specifically
including, but not limited to, brokerage commissions and advertising expenses incurred, expenses of remodeling the Premises or any portion thereof for a new tenant, whether for the same or a different use, and any special concessions made to obtain
a new tenant; and 
 (E) At Landlord’s election, such other amounts in addition to or in lieu of the foregoing
as may be permitted from time to time by applicable law. 
 As used in the foregoing subsection (c)(ii) (A) and (B),
the “worth at the time of award” shall be computed by allowing interest at the Default Rate. As used in subsection (c)(ii)(C) above, the “worth at the time of award” shall be computed by discounting such amount at
the discount rate of the Federal Reserve Bank of Boston at the time of award plus 1%. 
 (iii) Landlord may continue
this Lease in effect after Tenant’s Default and recover Rent as it becomes due (Landlord and Tenant hereby agreeing that Tenant has the right to sublet or assign hereunder, subject only to reasonable limitations). Accordingly, if Landlord does
not elect to terminate this Lease following a Default by Tenant, Landlord may, from time to time, without terminating this Lease, enforce all of its rights and remedies hereunder, including the right to recover all Rent as it becomes due. 

  
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 (iv) Intentionally Deleted. 

(v) Independent of the exercise of any other remedy of Landlord hereunder or under applicable law, upon the occurrence
of a monetary Default or Default pertaining to Tenant’s failure to comply with the requirements of Article 21, Landlord may conduct an environmental test of the Premises as generally described in Section 21.4 hereof, at
Tenant’s expense. 
 Notwithstanding anything to the contrary contained herein, in no event shall Tenant ever be liable to Landlord for
any special, indirect, consequential or punitive damages under this Lease except as may arise in connection with Tenant’s holding over of the Premises as set forth in Article 25. 

(d) Effect of Exercise. Exercise by Landlord of any remedies hereunder or otherwise available shall not be deemed to be an
acceptance of surrender of the Premises and/or a termination of this Lease by Landlord, it being understood that such surrender and/or termination can be effected only by the express written agreement of Landlord and Tenant. Any law, usage, or
custom to the contrary notwithstanding, Landlord shall have the right at all times to enforce the provisions of this Lease in strict accordance with the terms hereof; and the failure of Landlord at any time to enforce its rights under this Lease
strictly in accordance with same shall not be construed as having created a custom in any way or manner contrary to the specific terms, provisions, and covenants of this Lease or as having modified the same and shall not be deemed a waiver of
Landlord’s right to enforce one or more of its rights in connection with any subsequent default. A receipt by Landlord of Rent or other payment with knowledge of the breach of any covenant hereof shall not be deemed a waiver of such breach, and
no waiver by Landlord of any provision of this Lease shall be deemed to have been made unless expressed in writing and signed by Landlord. To the greatest extent permitted by law, Tenant waives all right of redemption in case Tenant shall be
dispossessed by a judgment or by warrant of any court or judge. Any reletting of the Premises or any portion thereof shall be on such terms and conditions as Landlord in its sole discretion may determine. Landlord shall not be liable for, nor shall
Tenant’s obligations hereunder be diminished because of, Landlord’s failure to relet the Premises or collect rent due in respect of such reletting or otherwise to mitigate any damages arising by reason of Tenant’s Default. 

ARTICLE 17 

ASSIGNMENT AND SUBLETTING 

17.1 General Prohibition. Without Landlord’s prior written consent which shall not be unreasonably withheld, conditioned or
delayed subject to and on the conditions described in this Section, Tenant shall not, directly or indirectly, voluntarily or by operation of law, assign this Lease or sublease the Premises or any part thereof or mortgage, pledge, or hypothecate its
leasehold interest or grant any concession or license within the Premises, and any attempt to do any of the foregoing shall be void and of no effect. 

17.2 Permitted Transfers. If Tenant desires to assign, sublease, hypothecate or otherwise transfer this Lease or sublet the
Premises other than pursuant to a Permitted Assignment (as defined below), then at least 15 Business Days, but not more than 45 Business Days, before the date Tenant desires the assignment or sublease to be effective (the “Assignment
Date”), Tenant shall give Landlord a notice (the “Assignment Notice”) containing such information about the 

  
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proposed assignee or sublessee, including the proposed use of the Premises and any Hazardous Materials proposed to be used, stored handled, treated, generated in or released or disposed of from
the Premises, the Assignment Date, any relationship between Tenant and the proposed assignee or sublessee, and all material terms and conditions of the proposed assignment or sublease, including a copy of any proposed assignment or sublease in its
final form, and such other information as Landlord may deem reasonably necessary or appropriate to its consideration whether to grant its consent. Landlord may, by giving written notice to Tenant within 10 Business Days after receipt of the
Assignment Notice: (i) grant such consent, or (ii) refuse such consent, in its reasonable discretion; or (iii) terminate this Lease with respect to the space described in the Assignment Notice as of the Assignment Date (an
“Assignment Termination”). Among other reasons, it shall be reasonable for Landlord to withhold its consent in any of these instances: (1) the proposed assignee or subtenant is a governmental agency; (2) in
Landlord’s reasonable judgment, the use of the Premises by the proposed assignee or subtenant would entail any Alterations that would substantially lessen the value of the leasehold improvements in the Premises, or would require substantially
increased services by Landlord; (3) in Landlord’s reasonable judgment, the proposed assignee or subtenant lacks the creditworthiness to support the financial obligations it will incur under the proposed assignment (4) in
Landlord’s reasonable judgment, the business of the proposed assignee or subtenant is inconsistent with the type and quality of the nature of the Building; (5) the use of the Premises by the proposed assignee or subtenant will violate any
applicable Legal Requirement; (6) Landlord has experienced previous defaults by or is in litigation with the proposed assignee or subtenant; or (7) the proposed assignee or subtenant is an existing tenant in the Building and Landlord has,
or within a reasonable time frame will have, vacant space of comparable size, or a prospective tenant with whom Landlord has been in negotiations within the previous six (6) months; or (8) if the assignment or subletting concerns more than
50% of the Premises, the net worth (as determined in accordance with generally accepted accounting principles) of the proposed assignee or subtenant is less than $10,000,000. If Landlord delivers notice of its election to exercise an Assignment
Termination, Tenant shall have the right to withdraw such Assignment Notice by written notice to Landlord of such election within 5 Business Days after Landlord’s notice electing to exercise the Assignment Termination. If Tenant withdraws such
Assignment Notice, this Lease shall continue in full force and effect. If Tenant does not withdraw such Assignment Notice, this Lease, and the term and estate herein granted, shall terminate as of the Assignment Date with respect to the space
described in such Assignment Notice. No failure of Landlord to exercise any such option to terminate this Lease, or to deliver a timely notice in response to the Assignment Notice, shall be deemed to be Landlord’s consent to the proposed
assignment, sublease or other transfer. Tenant shall reimburse Landlord for its reasonable, out of pocket costs in connection with its consideration of any Assignment Notice and/or its preparation or review of any consent documents (provided that
such expenses shall not exceed $5,000 in any one instance with respect to the approval of any assignments or sublets unless such assignment or sublease does not occur in the ordinary course of business (e.g. is in connection with a bankruptcy or
reorganization of tenant), involves additional documentation beyond Landlord’s customary form of consent or significant negotiation of the same, or Landlord provides unusual or extraordinary services in connection therewith). 

Notwithstanding the foregoing, Landlord’s consent to an assignment of this Lease or a subletting of any portion of the Premises to any
entity controlling, controlled by or under common control with Tenant (a “Control Permitted Assignment”) shall not be required, provided that Landlord shall have the right to approve the form of any such sublease or
assignment. In addition, 

  
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Tenant shall have the right to assign this Lease, upon prior written notice to Landlord but without obtaining Landlord’s prior written consent, to a corporation or other entity which is a
successor-in-interest to Tenant, by way of merger, consolidation or corporate reorganization, or by the purchase of all or substantially all of the assets or the ownership interests of Tenant provided that (i) such merger or consolidation, or
such acquisition or assumption, as the case may be, is for a good business purpose and not principally for the purpose of transferring the Lease, and (ii) the net worth (as determined in accordance with generally accepted accounting principles
(“GAAP”)) of the assignee is not less than the greater of the net worth (as determined in accordance with GAAP) of Tenant as of the date of this Lease or the date of Tenant’s most current quarterly or annual financial
statements, and (iii) such assignee shall agree in writing to assume all of the terms, covenants and conditions of this Lease arising after the effective date of the assignment (a “Corporate Permitted Assignment”).
Control Permitted Assignments and Corporate Permitted Assignments are hereinafter referred to as “Permitted Assignments.” 

Notwithstanding anything to the contrary in this Article, Tenant shall have the right to obtain financing from investors (including venture
capital funding and corporate partners) which invest in private companies or undergo a public offering which results in a change in control of Tenant without such change of control constituting an assignment under this Section requiring Landlord
consent, provided that (i) Tenant notifies Landlord in writing of the financing prior to the closing of the financing (or, if prohibited from so notifying Landlord by Legal Requirements or other contractual confidentiality obligations, then
promptly thereafter), and (ii) provided that in no event shall such financing result in a change in use of the Premises from the use contemplated by Tenant at the commencement of the Term. 

17.3 Additional Conditions. As a condition to any such assignment or subletting, whether or not Landlord’s consent is
required, Landlord may require: 
 (i) that any assignee or subtenant agree, in writing at the time of such assignment or subletting,
that if Landlord gives such party notice that Tenant is in Default under this Lease, such party shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments will be received by Landlord without any liability except to
credit such payment against those due under the Lease, and any such third party shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason; provided, however, in no event shall
Landlord or its successors or assigns be obligated to accept such attornment; and 
 (ii) A list of Hazardous Materials, certified by
the proposed assignee or sublessee to be true and correct, which the proposed assignee or sublessee intends to use, store, handle, treat, generate in or release or dispose of from the Premises, together with copies of all documents relating to such
use, storage, handling, treatment, generation, release or disposal of Hazardous Materials by the proposed assignee or subtenant in the Premises or on the Project, prior to the proposed assignment or subletting, including, without limitation:
permits; approvals; reports and correspondence; storage and management plans; plans relating to the installation of any storage tanks to be installed in or under the Project (provided, said installation of tanks shall only be permitted after
Landlord has given its written consent to do so, which consent may be withheld in Landlord’s sole and absolute discretion); and all closure plans or any other documents required by any and all federal, state and local Governmental Authorities
for any storage tanks 

  
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installed in, on or under the Project for the closure of any such tanks. Neither Tenant nor any such proposed assignee or subtenant is required, however, to provide Landlord with any portion(s)
of the such documents containing information of a proprietary nature which, in and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. 

17.4 No Release of Tenant, Sharing of Excess Rents. Notwithstanding any assignment or subletting, Tenant shall at all times
remain fully and primarily responsible and liable for the payment of Rent and for compliance with all of Tenant’s other obligations under this Lease. If the Rent due and payable by a sublessee or assignee (or a combination of the rental payable
under such sublease or assignment plus any bonus or other consideration therefor or incident thereto in any form) exceeds the sum of the rental payable under this Lease, (excluding however, any Rent payable under this Section) and actual and
reasonable brokerage fees, legal costs and any design or construction fees directly related to and required pursuant to the terms of any such sublease and any unamortized tenant improvement expenses paid by Tenant in excess of Landlord’s
Contribution) (“Excess Rent”), then Tenant shall be bound and obligated to pay Landlord as Additional Rent hereunder 50% of such Excess Rent within 10 days following receipt thereof by Tenant. If Tenant shall sublet the
Premises or any part thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all rent from any such subletting, and Landlord as assignee and as attorney-in-fact for Tenant,
or a receiver for Tenant appointed on Landlord’s application, may collect such rent and apply it toward Tenant’s obligations under this Lease; except that, until the occurrence of a Default, Tenant shall have the right to collect and
retain such rent. 
 17.5 No Waiver. The consent by Landlord to an assignment or subletting shall not relieve Tenant or any
assignees of this Lease or any sublessees of the Premises from obtaining the consent of Landlord to any further assignment or subletting nor shall it release Tenant or any assignee or sublessee of Tenant from full and primary liability under the
Lease. The acceptance of Rent hereunder, or the acceptance of performance of any other term, covenant, or condition thereof, from any other person or entity shall not be deemed to be a waiver of any of the provisions of this Lease or a consent to
any subletting, assignment or other transfer of the Premises. 
 17.6 Prior Conduct of Proposed Transferee. Notwithstanding any other
provision of this Section, if the proposed assignee or sublessee has operations in the Commonwealth of Massachusetts that are or have been subject to an enforcement order issued by any Governmental Authority and such operations are substantially
comparable to the operations proposed by the assignee or sublessee for the Premises in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any order related to
the failure to make a required reporting to any Governmental Authority) pertaining to a use similar to the Permitted Use, Landlord shall have the absolute right to refuse to consent to any assignment or subletting to any such party. 

ARTICLE 18 
 ESTOPPEL
CERTIFICATE 
 18.1 Estoppel Certificate. Tenant shall, within 10 Business Days of written notice from Landlord,
execute, acknowledge and deliver a statement to Landlord, or any prospective purchaser or lender, in writing (i) certifying that this Lease is unmodified and in full force and effect (or, if 

  
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modified, stating the nature of such modification and certifying that this Lease as so modified is in full force and effect) and the dates to which the rental and other charges are paid in
advance, if any, (ii) acknowledging whether or not any uncured defaults exist on the part of Landlord hereunder, or specifying such defaults if any are claimed, and (iii) setting forth such further information with respect to the status of this
Lease or the Premises as may be requested thereon. Any such statement may be relied upon by any prospective purchaser or encumbrancer of all or any portion of the real property of which the Premises are a part. Tenant’s failure to deliver such
statement within such time shall, at the option of Landlord, constitute a Default under this Lease, and, in any event, shall be conclusive upon Tenant that the Lease is in full force and effect and without modification except as may be represented
by Landlord in any certificate prepared by Landlord and delivered to Tenant for execution. Landlord shall, within 10 Business Days of written notice from Tenant, execute, acknowledge and deliver a comparable statement to Tenant. 

ARTICLE 19 

SUBORDINATION 

19.1 Subordination. This Lease and Tenant’s interest and rights hereunder are hereby made and shall be subject and
subordinate at all times to the lien of any Mortgage now existing or hereafter created on or against the Project or the Premises, and all amendments, restatements, renewals, modifications, consolidations, refinancing, assignments and extensions
thereof, provided that the Holder of such Mortgage delivers to Tenant a subordination, non-disturbance and attornment agreement on such holder’s standard and customary form provided that such holder is an institutional lender or investor.
Tenant agrees, at the election of the Holder of any such Mortgage, to attorn to any such Holder. Notwithstanding the foregoing, any such Holder may at any time subordinate its Mortgage to this Lease, without Tenant’s consent, by notice in
writing to Tenant, and thereupon this Lease shall be deemed prior to such Mortgage without regard to their respective dates of execution, delivery or recording and in that event such Holder shall have the same rights with respect to this Lease as
though this Lease had been executed prior to the execution, delivery and recording of such Mortgage and had been assigned to such Holder. The term “Mortgage” whenever used in this Lease shall be deemed to include deeds of
trust, security assignments and any other encumbrances, and any reference to the “Holder” of a Mortgage shall be deemed to include the beneficiary under a deed of trust. 

ARTICLE 20 

SURRENDER 
 20.1
Surrender. Upon the expiration of the Term or earlier termination of Tenant’s right of possession, Tenant shall surrender the Premises to Landlord in the condition the Premises are required to be maintained during the Term, along
with any Alterations or Installations permitted by Landlord to remain in the Premises pursuant to the provisions of this Lease, free of Hazardous Materials brought upon, kept, used, stored, handled, treated, generated in, or released or disposed of
from, the Premises by Tenant or any Tenant Party or subtenant (collectively, “Tenant HazMat Operations”) and released of all Hazardous Materials Clearances, broom clean, ordinary wear and tear and casualty loss and
condemnation covered by Sections 14 and 15 excepted. At least 3 months prior to the surrender of the Premises, Tenant shall deliver to Landlord a narrative description of the actions proposed (or required by any Governmental Authority)
to be taken by Tenant in order to surrender the Premises (including any Installations permitted by Landlord to 

  
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remain in the Premises) at the expiration or earlier termination of the Term, free from any residual impact from the Tenant HazMat Operations and otherwise released for unrestricted use and
occupancy (the “Surrender Plan”). Such Surrender Plan shall be accompanied by a current listing of (i) all Hazardous Materials licenses and permits held by or on behalf of any Tenant Party with respect to the Premises,
and (ii) all Hazardous Materials used, stored, handled, treated, generated, released or disposed of from the Premises, and shall be subject to the review and approval of Landlord’s environmental consultant. In connection with the review
and approval of the Surrender Plan, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such additional non-proprietary information concerning Tenant HazMat Operations as Landlord shall request. On or before such
surrender, Tenant shall deliver to Landlord evidence that the approved Surrender Plan shall have been satisfactorily completed and Landlord shall have the right, subject to reimbursement at Tenant’s expense as set forth below, to cause
Landlord’s environmental consultant to inspect the Premises and perform such additional procedures as may be deemed reasonably necessary to confirm that the Premises are, as of the effective date of such surrender or early termination of the
Lease, free from any residual impact from Tenant HazMat Operations. Tenant shall reimburse Landlord, as Additional Rent, for the actual out-of pocket expense incurred by Landlord for Landlord’s environmental consultant to review and approve the
Surrender Plan and to visit the Premises and verify satisfactory completion of the same, which cost shall not exceed $5,000. Landlord shall have the unrestricted right to deliver such Surrender Plan and any report by Landlord’s environmental
consultant with respect to the surrender of the Premises to third parties. 
 If Tenant shall fail to prepare or submit a Surrender Plan
approved by Landlord, or if Tenant shall fail to complete the approved Surrender Plan, or if such Surrender Plan, whether or not approved by Landlord, shall fail to adequately address any residual effect of Tenant HazMat Operations in, on or about
the Premises, Landlord shall have the right to take such actions as Landlord may deem reasonable or appropriate to assure that the Premises and the Project are surrendered free from any residual impact from Tenant HazMat Operations, the cost of
which actions shall be reimbursed by Tenant as Additional Rent, without regard to the limitation set forth in the first paragraph of this Section. 

Tenant shall immediately return to Landlord all keys and/or access cards to parking, the Project, restrooms or all or any portion of the
Premises furnished to or otherwise procured by Tenant. If any such access card or key is lost, Tenant shall pay to Landlord, at Landlord’s election, either the cost of replacing such lost access card or key or the cost of reprogramming the
access security system in which such access card was used or changing the lock or locks opened by such lost key. Any Tenant’s Property, Alterations and property not so removed by Tenant as permitted or required herein shall be deemed abandoned
and may be stored, removed, and disposed of by Landlord at Tenant’s expense, and Tenant waives all claims against Landlord for any damages resulting from Landlord’s retention and/or disposition of such property. All obligations of Tenant
hereunder not fully performed as of the termination of the Term, including the obligations of Tenant under Article 21 hereof, shall survive the expiration or earlier termination of the Term, including, without limitation, indemnity obligations,
payment obligations with respect to Rent and obligations concerning the condition and repair of the Premises. 

  
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 ARTICLE 21 

ENVIRONMENTAL REQUIREMENTS 

21.1 Prohibition/Compliance/Indemnity. Tenant shall not cause or permit any Hazardous Materials (as hereinafter defined) to be
brought upon, kept, used, stored, handled, treated, generated in or about, or released or disposed of from, the Premises or the Project in violation of applicable Environmental Requirements (as hereinafter defined) by Tenant or any Tenant Party or
subtenant. If Tenant breaches the obligation stated in the preceding sentence, or if the presence of Hazardous Materials in the Premises is caused or permitted by Tenant or any Tenant Party during the Term or any holding over results in
contamination of the Premises, the Project or any adjacent property, or if contamination of the Premises, the Project or any adjacent property by Hazardous Materials brought into, kept, used, stored, handled, treated, generated in or about, or
released or disposed of from, the Premises by Tenant or any Tenant Party or subtenant otherwise occurs during the Term or any holding over, Tenant hereby indemnifies and shall defend and hold Landlord, its officers, directors, employees, agents and
contractors harmless from any and all actions (including, without limitation, remedial or enforcement actions of any kind, administrative or judicial proceedings, and orders or judgments arising out of or resulting therefrom), costs, claims, damages
(including, without limitation, punitive damages and damages based upon diminution in value of the Premises or the Project, or the loss of, or restriction on, use of the Premises or any portion of the Project), expenses (including, without
limitation, attorneys’, consultants’ and experts’ fees, court costs and amounts paid in settlement of any claims or actions), fines, forfeitures or other civil, administrative or criminal penalties, injunctive or other relief (whether
or not based upon personal injury, property damage, or contamination of, or adverse effects upon, the environment, water tables or natural resources), liabilities or losses (collectively, “Environmental Claims”) which arise
during or after the Term as a result of such contamination. This indemnification of Landlord by Tenant includes, without limitation, costs incurred in connection with any investigation of site conditions or any cleanup, treatment, remedial, removal,
or restoration work required by any federal, state or local Governmental Authority because of Hazardous Materials present in the air, soil or ground water above, on, or under the Premises. Without limiting the foregoing, if the presence of any
Hazardous Materials on the Premises, the Project or any adjacent property caused or permitted by Tenant or any Tenant Party results in any contamination of the Premises, the Project or any adjacent property, Tenant shall promptly take all actions at
its sole expense and in accordance with applicable Environmental Requirements as are necessary to return the Premises, the Project or any adjacent property to the condition existing prior to the time of such contamination, provided that
Landlord’s approval of such action shall first be obtained, which approval shall not unreasonably be withheld so long as such actions would not potentially have any material adverse long-term or short-term effect on the Premises or the Project.

 Notwithstanding anything to the contrary contained in this Section 20, Tenant shall not be responsible for, and the indemnification
and hold harmless obligation set forth in this paragraph shall not apply to (i) contamination in the Premises which existed in the Premises prior to the Commencement Date, or (ii) the presence of any Hazardous Materials in the Premises
which migrated from outside of the Premises into the Premises, or (iii) contamination caused by Landlord or any Landlord Party. 

  
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 21.2 Business. Landlord acknowledges that it is not the intent of this Section to
prohibit Tenant from using the Premises for the Permitted Use. Tenant may operate its business according to prudent industry practices so long as the use or presence of Hazardous Materials is strictly and properly monitored according to all then
applicable Environmental Requirements. As a material inducement to Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant agrees to deliver to Landlord prior to the Lease Commencement Date a list identifying each
type of Hazardous Materials to be brought upon, kept, used, stored, handled, treated, generated on, or released or disposed of from, the Premises and setting forth any and all governmental approvals or permits required in connection with the
presence, use, storage, handling, treatment, generation, release or disposal of such Hazardous Materials on or from the Premises (“Hazardous Materials List”). Tenant shall deliver to Landlord an updated Hazardous Materials
List at least once a year and shall also deliver an updated list before any new Hazardous Material is brought onto, kept, used, stored, handled, treated, generated on, or released or disposed of from, the Premises. Tenant shall deliver to Landlord
true and correct copies of the following documents (the “Haz Mat Documents”) relating to the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials prior to the Lease Commencement Date, or
if unavailable at that time, concurrent with the receipt from or submission to a Governmental Authority: permits; approvals; reports and correspondence; storage and management plans, notice of violations of any Legal Requirements; plans relating to
the installation of any storage tanks to be installed in the Project (provided, said installation of tanks shall only be permitted in compliance with the applicable Legal Requirements and subject to any reasonable conditions or requirements imposed
by Landlord); all closure plans or any other documents required by any and all federal, state and local Governmental Authorities for any storage tanks installed in, on or under the Project for the closure of any such tanks; and a Surrender Plan (to
the extent surrender in accordance with Article 20 cannot be accomplished in 3 months). Tenant is not required, however, to provide Landlord with any portion(s) of the Haz Mat Documents containing information of a proprietary nature which, in and of
themselves, do not contain a reference to any Hazardous Materials or hazardous activities. It is not the intent of this Section to provide Landlord with information which could be detrimental to Tenant’s business should such information become
possessed by Tenant’s competitors. 
 21.3 Tenant Representation and Warranty. Tenant hereby represents and warrants to
Landlord that (i) neither Tenant nor any of its legal predecessors has been required by any prior landlord, lender or Governmental Authority at any time to take remedial action in connection with Hazardous Materials contaminating a property
which contamination was permitted by Tenant of such predecessor or resulted from Tenant’s or such predecessor’s action or use of the property in question, and (ii) Tenant is not subject to any enforcement order issued by any
Governmental Authority in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any order related to the failure to make a required reporting to any Governmental
Authority). If Landlord determines that this representation and warranty was not true as of the date of this lease, Landlord shall have the right to terminate this Lease in Landlord’s sole and absolute discretion. 

21.4 Testing. If any Governmental Authority requires testing to determine whether any contamination of the Premises or the
Project has occurred as a result of Tenant’s use, then Landlord shall have the right to conduct such testing at Tenant’s expense. If Tenant conducts its own tests of the Premises using third party contractors and test procedures acceptable
to Landlord (and such Governmental Authority), which tests are certified to Landlord (and such Governmental Authority), Landlord shall accept such tests in lieu of the tests to be paid for by Tenant. In


  
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addition, at any time, and from time to time, prior to the expiration or earlier termination of the Term, Landlord shall have the right to conduct appropriate tests of the Premises and the
Project to determine if contamination has occurred as a result of Tenant’s use of the Premises. In connection with such testing, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such non-proprietary information
concerning the use of Hazardous Materials in or about the Premises by Tenant or any Tenant Party. If contamination has occurred for which Tenant is liable under this Section, Tenant shall pay all costs to conduct such tests. If no such contamination
is found, Landlord shall pay the costs of such tests (which shall not constitute an Operating Expense). Landlord shall provide Tenant with a copy of all third party, non-confidential reports and tests of the Premises made by or on behalf of Landlord
during the Term without representation or warranty and subject to a confidentiality agreement. Tenant shall, at its sole cost and expense, promptly and satisfactorily remediate any environmental conditions identified by such testing for which Tenant
is responsible hereunder in accordance with all Environmental Requirements. Landlord’s receipt of or satisfaction with any environmental assessment in no way waives any rights which Landlord may have against Tenant. 

21.5 Control Areas. Tenant shall be allowed to utilize up to its pro rata share of the Hazardous Materials inventory within any
control area or zone (located within the Premises), as designated by the applicable building code, for chemical use or storage. As used in the preceding sentence, Tenant’s pro rata share of any control areas or zones located within the Premises
shall be determined based on the rentable square footage that Tenant leases within the applicable control area or zone. For purposes of example only, if a control area or zone contains 10,000 rentable square feet and 2,000 rentable square feet of a
tenant’s premises are located within such control area or zone (while such premises as a whole contains 5,000 rentable square feet), the applicable tenant’s pro rata share of such control area would be 20%. 

21.6 Intentionally Deleted. 

21.7 Tenant’s Obligations. Tenant’s obligations under this Section shall survive the expiration or earlier termination
of the Lease. any period of time after the expiration or earlier termination of this Lease required by Tenant or Landlord to complete the removal from the Premises of any Hazardous Materials (including, without limitation, the release and
termination of any licenses or permits restricting the use of the Premises and the completion of the approved Surrender Plan), Tenant shall continue to pay the full Rent in accordance with this Lease for any portion of the Premises not relet by
Landlord in Landlord’s sole discretion, which Rent shall be prorated daily. 
 21.8 Definitions. As used herein, the term
“Environmental Requirements” means all applicable present and future statutes, regulations, ordinances, rules, codes, judgments, orders or other similar enactments of any Governmental Authority regulating or relating to
health, safety, or environmental conditions on, under, or about the Premises or the Project, or the environment, including without limitation, the following: the Comprehensive Environmental Response, Compensation and Liability Act; the Resource
Conservation and Recovery Act; and all state and local counterparts thereto, and any regulations or policies promulgated or issued thereunder. As used herein, the term “Hazardous Materials” means and includes any substance,
material, waste, pollutant, or contaminant listed or defined as hazardous or toxic (other than reasonable amounts of routine cleaning products), or regulated by reason of its impact or potential impact on humans,


  
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animals and/or the environment under any Environmental Requirements, asbestos and petroleum, including crude oil or any fraction thereof, natural gas liquids, liquefied natural gas, or synthetic
gas usable for fuel (or mixtures of natural gas and such synthetic gas). As defined in Environmental Requirements, Tenant is and shall be deemed to be the “operator” of Tenant’s “facility” and the
“owner” of all Hazardous Materials brought on the Premises by Tenant or any Tenant Party, and the wastes, by-products, or residues generated, resulting, or produced therefrom. 

ARTICLE 22 

TENANT’S REMEDIES/LIMITATION OF LIABILITY 

22.1 Tenant’s Remedies/Limitation of Liability. Landlord shall not be in default hereunder unless Landlord fails to perform
any of its obligations hereunder within 30 days after written notice from Tenant specifying such failure (unless such performance will, due to the nature of the obligation, require a period of time in excess of 30 days, then after such period of
time as is reasonably necessary, provided that Landlord shall diligently and continuously pursue such cure). Upon any default by Landlord, Tenant shall give notice by registered or certified mail to any Holder of a Mortgage covering the Premises and
to any landlord of any lease of property in or on which the Premises are located and Tenant shall offer such Holder and/or landlord a reasonable opportunity to cure the default, including time to obtain possession of the Project by power of sale or
a judicial action if such should prove necessary to effect a cure; provided Landlord shall have furnished in advance to Tenant in writing the names and addresses of all such persons who are to receive such notices. All obligations of Landlord
hereunder shall be construed as covenants, not conditions; and, except as may be otherwise expressly provided in this Lease, Tenant may not terminate this Lease for breach of Landlord’s obligations hereunder. 

All obligations of Landlord under this Lease arising or accruing during the period of such Landlord’s ownership of the Premises, and not
thereafter, will be binding upon Landlord. The term “Landlord” in this Lease shall mean only the owner for the time being of the Premises. Upon the transfer by such owner of its interest in the Premises, such owner shall thereupon be
released and discharged from all obligations of Landlord thereafter accruing, but such obligations shall be binding during the Term upon each new owner for the duration of such owner’s ownership. 

22.2 Limitation on Landlord’s Liability. NOTWITHSTANDING ANYTHING SET FORTH HEREIN OR IN ANY OTHER AGREEMENT BETWEEN
LANDLORD AND TENANT TO THE CONTRARY: (A) EXCEPT TO THE EXTENT ARISING AS A RESULT OF THE NEGLIGENCE OR WILLFUL MISCONDUCT OF LANDLORD OR ANY LANDLORD PARTY, LANDLORD SHALL NOT BE LIABLE TO TENANT OR ANY OTHER PERSON FOR (AND TENANT AND EACH
SUCH OTHER PERSON ASSUME ALL RISK OF) LOSS, DAMAGE OR INJURY, TO: TENANT’S PERSONAL PROPERTY OF EVERY KIND AND DESCRIPTION, INCLUDING, WITHOUT LIMITATION TRADE FIXTURES, EQUIPMENT, INVENTORY, SCIENTIFIC RESEARCH, SCIENTIFIC EXPERIMENTS,
LABORATORY ANIMALS, PRODUCT, SPECIMENS, SAMPLES, AND/OR SCIENTIFIC, BUSINESS, ACCOUNTING AND OTHER RECORDS OF EVERY KIND AND DESCRIPTION KEPT AT THE PREMISES AND ANY AND ALL INCOME DERIVED OR DERIVABLE THEREFROM; (B) THERE SHALL BE NO PERSONAL
RECOURSE TO LANDLORD FOR ANY ACT OR OCCURRENCE IN, ON OR ABOUT THE PREMISES OR ARISING IN ANY WAY UNDER THIS LEASE OR ANY OTHER 

  
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AGREEMENT BETWEEN LANDLORD AND TENANT WITH RESPECT TO THE SUBJECT MATTER HEREOF AND ANY LIABILITY OF LANDLORD HEREUNDER SHALL BE STRICTLY LIMITED SOLELY TO LANDLORD’S INTEREST IN THE PROJECT
OR ANY PROCEEDS FROM SALE OR CONDEMNATION THEREOF AND ANY INSURANCE PROCEEDS PAYABLE IN RESPECT OF LANDLORD’S INTEREST IN THE PROJECT OR IN CONNECTION WITH ANY SUCH LOSS; AND (C) IN NO EVENT SHALL ANY PERSONAL LIABILITY BE ASSERTED AGAINST
LANDLORD IN CONNECTION WITH THIS LEASE NOR SHALL ANY RECOURSE BE HAD TO ANY OTHER PROPERTY OR ASSETS OF LANDLORD OR ANY OF LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS. UNDER NO CIRCUMSTANCES SHALL LANDLORD OR ANY OF
LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS BE LIABLE FOR INJURY TO TENANT’S BUSINESS OR FOR ANY LOSS OF INCOME OR PROFIT THEREFROM. NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED HEREIN, IN NO EVENT SHALL LANDLORD
EVER BE LIABLE TO TENANT FOR ANY SPECIAL, INDIRECT, CONSEQUENTIAL OR PUNITIVE DAMAGES UNDER THIS LEASE 
 ARTICLE 23 

INSPECTION AND ACCESS 

23.1 Inspection and Access. Landlord and its agents, representatives, and contractors may enter the Premises during business
hours on not less than 48 hours advance written notice (except in the case of emergencies in which case no such notice shall be required and such entry may be at any time) for the purpose of making such repairs as may be required or permitted
pursuant to the Lease, inspecting the Premises, showing the Premises to prospective purchasers or lenders and, during the last year of the Term, to prospective tenants, and at any time during the Term for any other business purpose. Notwithstanding
the foregoing, Landlord acknowledges that the Premises may contain confidential proprietary information and research and laboratory experiments. Accordingly, Tenant may elect to have a Tenant representative accompany any such tours with prospective
purchasers, tenants or lenders. If Tenant does not so elect to have a representative accompany the tour within 24 hours after receiving Landlord’s notice, Tenant shall be deemed to have waiver such right. 

Landlord may grant easements, make public dedications, designate Common Areas and create restrictions pertaining to the Project, provided that
no such easement, dedication, designation or restriction materially, adversely affects Tenant’s use or occupancy of the Premises for the Permitted Use. At Landlord’s request, Tenant shall execute such instruments as may be necessary for
such easements, dedications or restrictions. Tenant shall at all times, except in the case of emergencies, have the right to escort Landlord or its agents, representatives, contractors or guests while the same are in the Premises, provided such
escort does not materially and adversely affect Landlord’s access rights hereunder 

  
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 ARTICLE 24 

SIGNAGE 
 24.1
Signs; Exterior Appearance. Tenant shall not, without the prior written consent of Landlord, which may be granted or withheld in Landlord’s sole but reasonable discretion: (i) attach any awnings, exterior lights, decorations,
balloons, flags, pennants, banners, painting or other projection to any outside wall of the Project, (ii) use any curtains, blinds, shades or screens other than Landlord’s standard window coverings, (iii) coat or otherwise sunscreen
the interior or exterior of any windows, (iv) place any bottles, parcels, or other articles on the window sills, (v) place any equipment, furniture or other items of personal property on any exterior balcony, or (vi) paint, affix or
exhibit on any part of the Premises or the Project any signs, notices, window or door lettering, placards, decorations, or advertising media of any type which can be viewed from the exterior of the Building. Landlord shall provide at Landlord’s
expense building standard signage in the lobby and at Tenant’s entrance. Notwithstanding the foregoing, if Tenant occupies the entire floor, Tenant may install at Tenant’s expense Tenant’s signage in the elevator lobby in a size and
location to be determined and subject to Landlord’s approval which will not be unreasonably withheld, conditioned or delayed. Notwithstanding the foregoing, provided that Tenant occupies at least the entire third floor, and subject to the
rights of Foundation Medicine, Tenant shall have a non-exclusive right to install at Tenant’s expense exterior signage on the Building façade in a location and with a design, size and operation subject to Landlord’s approval which
shall not be unreasonably conditioned, withheld or delayed, and subject to the applicable Legal Requirements of the City of Cambridge. Tenant shall be responsible for all costs relating to the permitting, installation and maintenance of the signage.
Tenant shall remove any such signage, and repair any damage caused by such removal, prior to the expiration or earlier termination of this Lease. 

ARTICLE 25 
 HOLDING
OVER 
 25.1 Holding Over. If, with Landlord’s express written consent, Tenant retains possession of the Premises
after the termination of the Term, (i) unless otherwise agreed in such written consent, such possession shall be subject to immediate termination by Landlord at any time, (ii) all of the other terms and provisions of this Lease shall
remain in full force and effect (excluding any expansion or renewal option or other similar right or option) during such holdover period, (iii) Tenant shall continue to pay Base Rent in the amount payable upon the date of the expiration or
earlier termination of this Lease, and (iv) all other payments shall continue under the terms of this Lease. If Tenant remains in possession of the Premises after the expiration or earlier termination of the Term without the express written
consent of Landlord, Tenant shall become a tenant at sufferance upon the terms of this Lease except that the monthly rental shall be equal to 150% of Base Rent in effect during the last 30 days of the Term, plus all other Additional Rent hereunder,
and Tenant shall be responsible for all damages suffered by Landlord resulting from or occasioned by Tenant’s holding over, including consequential damages. No holding over by Tenant, whether with or without consent of Landlord, shall operate
to extend this Lease except as otherwise expressly provided, and this Section shall not be construed as consent for Tenant to retain possession of the Premises. Acceptance by Landlord of Rent after the expiration of the Term or earlier termination
of this Lease shall not result in a renewal or reinstatement of this Lease. 

  
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 ARTICLE 26 

WAIVER OF JURY TRIAL 

26.1 Waiver of Jury Trial. TO THE EXTENT PERMITTED BY LAW, TENANT AND LANDLORD WAIVE ANY RIGHT TO TRIAL BY JURY OR TO HAVE A
JURY PARTICIPATE IN RESOLVING ANY DISPUTE, WHETHER SOUNDING IN CONTRACT, TORT, OR OTHERWISE, BETWEEN LANDLORD AND TENANT ARISING OUT OF THIS LEASE OR ANY OTHER INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN CONNECTION HEREWITH OR THE
TRANSACTIONS RELATED HERETO. 
 ARTICLE 27 

SECURITY DEPOSIT 

27.1 Security Deposit. Tenant shall deposit with Landlord, upon delivery of an executed copy of this Lease to Landlord, a
security deposit (the “Security Deposit”) for the performance of all of Tenant’s obligations hereunder in the amount set forth in Section 1.1 of this Lease, which Security Deposit shall be in the form
of an unconditional and irrevocable letter of credit (the “Letter of Credit”): (i) in form and substance satisfactory to Landlord, (ii) naming Landlord as beneficiary, (iii) expressly allowing Landlord to draw
upon it at any time from time to time by delivering to the issuer notice that Landlord is entitled to draw thereunder, (iv) issued by an FDIC-insured financial institution satisfactory to Landlord, (v) redeemable by presentation of a sight
draft in the state of Landlord’s choice, and (vi) transferable without fee or cost to Landlord. If Tenant does not provide Landlord with a substitute Letter of Credit complying with all of the requirements hereof at least 10 days before
the stated expiration date of any then current Letter of Credit, Landlord shall have the right to draw the full amount of the current Letter of Credit and hold the funds drawn in cash without obligation for interest thereon as the Security Deposit.
The Letter of Credit shall be held by Landlord as security for the performance of Tenant’s obligations under this Lease. The Letter of Credit is not an advance rental deposit or a measure of Landlord’s damages in case of Tenant’s
default. Upon each occurrence of a Default (as defined in Section 16.1), Landlord may draw all or any part of the Letter of Credit to pay delinquent payments due under this Lease, future rent damages, and the cost of any damage,
injury, expense or liability caused by such Default, without prejudice to any other remedy provided herein or provided by law. Landlord’s right to use the Letter of Credit under this Section includes the right to use the Letter of Credit to pay
future rent damages following the termination of this Lease pursuant to Section 16.2 below. Upon any use of all or any portion of the Letter of Credit, Tenant shall on demand deliver a new Letter of Credit or amend the existing
Letter of Credit to restore the Letter of Credit to the amount set forth on Page 1 of this Lease. Tenant hereby waives the provisions of any law, now or hereafter in force which provide that Landlord may claim from a security deposit only those sums
reasonably necessary to remedy defaults in the payment of Rent, to repair damage caused by Tenant or to clean the Premises, it being agreed that Landlord may, in addition, claim those sums reasonably necessary to compensate Landlord for any other
loss or damage, foreseeable or unforeseeable, caused by the Default of Tenant. Upon bankruptcy or other debtor-creditor proceedings against Tenant, the Letter of Credit shall be deemed to be applied first to the payment of Rent and other charges due
Landlord for periods prior to the filing of such proceedings. The Letter of Credit, or any balance thereof (i.e., after deducting therefrom all amounts to which Landlord is entitled under the provisions of this Lease), shall be returned to Tenant
(or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within 90 days after the expiration or earlier termination of this Lease. 

  
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 Provided that no Default (as defined in Section 16.1) has occurred or event that with the
passage of time, or the giving of notice, or both, would constitute a Default has occurred that remains uncured, the amount of the Security Deposit shall be reduced to the following amounts: (i) $1,044,247.90 effective as of the Rent
Commencement Date; (ii) $835,398.32 effective as of the first anniversary of the Rent Commencement Date; and (iii) $626,548.74 effective as of the second anniversary of the Rent Commencement Date. Within thirty (30) days following
receipt of Tenant’s written request for the applicable reduction, any portion of the Security Deposit in excess of the respective reduced amounts shall, if held by Landlord in cash, be refunded to Tenant, without interest, or Landlord shall
agree to an appropriate replacement or amendment of the Letter of Credit in order to effect the applicable reduction. 
 If Landlord
transfers its interest in the Project or this Lease, Landlord shall either (a) transfer any Security Deposit then held by Landlord to a person or entity assuming Landlord’s obligations under this Section, or (b) return to Tenant any
Security Deposit then held by Landlord and remaining after the deductions permitted herein. Upon such transfer to such transferee or the return of the Security Deposit to Tenant, Landlord shall have no further obligation with respect to the Security
Deposit, and Tenant’s right to the return of the Security Deposit shall apply solely against Landlord’s transferee. The Security Deposit is not an advance rental deposit or a measure of Landlord’s damages in case of Tenant’s
default. Landlord’s obligation respecting the Security Deposit is that of a debtor, not a trustee, and no interest shall accrue thereon. 

ARTICLE 28 
 RIGHT TO
EXTEND TERM 
 28.1 Extension Rights. Tenant shall have one right (an “Extension Right”) to
extend the term of this Lease for five (5) years (an “Extension Term”) on the same terms and conditions as this Lease (other than with respect to Base Rent and the Landlord’s Work) by giving Landlord written notice
of its election to exercise the Extension Right no sooner than fifteen (15) months earlier than and at least 12 months prior to the expiration of the Base Term of the Lease. 

Upon the commencement of the Extension Term, Base Rent shall be equal to the Market Rate (as defined below). Base Rent shall thereafter be
adjusted on each annual anniversary of the commencement of the Extension Term by multiplying the Base Rent payable immediately before such adjustment by the Rent Adjustment Percentage and adding the resulting amount to the Base Rent payable
immediately before such adjustment. As used herein, “Market Rate” shall mean the then market rental rate for space that includes laboratory and office space in the Cambridge, Massachusetts area of comparable age, quality,
level of finish and proximity to amenities and public transportation as the Premises, as determined by Landlord and agreed to by Tenant. In addition, Landlord may impose a market rent for the parking rights provided hereunder. 

If, on or before the date which is 180 days prior to the expiration of the Base Term of this Lease, Tenant has not agreed with Landlord’s
determination of the Market Rate during the Extension Term after negotiating in good faith, Tenant shall be deemed to have elected arbitration as described in this Article. Tenant acknowledges and agrees that, if Tenant has elected to exercise the
Extension Right by delivering notice to Landlord as required in this Article, Tenant shall have no right thereafter to rescind or elect not to extend the term of the Lease for the Extension Term. 

  
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 28.2 Arbitration. Within ten (10) days after Tenant’s notice to Landlord
of its election (or deemed election) to arbitrate Market Rate, each party shall deliver to the other a proposal containing the Market Rate that the submitting party believes to be correct (“Extension Proposal”). If either
party fails to timely submit an Extension Proposal, the other party’s submitted proposal shall determine the Base Rent for the Extension Term. If both parties submit Extension Proposals, then Landlord and Tenant shall meet within seven
(7) days after delivery of the last Extension Proposal and make a good faith attempt to mutually appoint a single Arbitrator (and defined below) to determine the Market Rate. If Landlord and Tenant are unable to agree upon a single Arbitrator,
then each shall, by written notice delivered to the other within ten (10) days after the meeting, select an Arbitrator. If either party fails to timely give notice of its selection for an Arbitrator, the other party’s submitted proposal
shall determine the Base Rent for the Extension Term. The two Arbitrators so appointed shall, within five (5) Business Days after their appointment, appoint a third Arbitrator. If the two Arbitrators so selected cannot agree on the selection of
the third Arbitrator within the time above specified, then either party, on behalf of both parties, may request such appointment of such third Arbitrator by application to any state court of general jurisdiction in the jurisdiction in which the
Premises are located, upon ten (10) days prior written notice to the other party of such intent. 
 (a) The decision of the
Arbitrator(s) shall be made within thirty (30) days after the appointment of a single Arbitrator or the third Arbitrator, as applicable. The decision of the single Arbitrator shall be final and binding upon the parties. The average of the two
closest Arbitrators in a three Arbitrator panel shall be final and binding upon the parties. Each party shall pay the fees and expenses of the Arbitrator appointed by or on behalf of such party and the fees and expenses of the third Arbitrator shall
be borne equally by both parties. If the Market Rate is not determined by the first day of the Extension Term, then Tenant shall pay Landlord Base Rent in an amount equal to the Base Rent in effect immediately prior to the Extension Term until such
determination is made. After the determination of the Market Rate, the parties shall make any necessary adjustments to such payments made by Tenant. Landlord and Tenant shall then execute an amendment recognizing the Market Rate for the Extension
Term. 
 (b) An “Arbitrator” shall be any person appointed by or on behalf of either party or appointed
pursuant to the provisions hereof and: (i) shall be (A) a member of the American Institute of Real Estate Appraisers with not less than ten (10) years of experience in the appraisal of improved office and high tech and life sciences
laboratory real estate in the greater Boston, Massachusetts metropolitan area, or (B) a licensed commercial real estate broker with not less than ten (10) years experience representing landlords and/or tenants in the leasing of high tech
or life sciences space in Cambridge, Massachusetts, (ii) devoting substantially all of their time to professional appraisal or brokerage work, as applicable, at the time of appointment and (iii) be in all respects impartial and
disinterested. 
 28.3 Rights Personal. The Extension Right is personal to Tenant and is not assignable without
Landlord’s consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s interest in the Lease. 

  
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 28.4 Exceptions. Notwithstanding anything set forth above to the contrary, at
Landlord’s option, the Extension Right shall not be in effect and Tenant may not exercise the Extension Right: 
 (i)
during any period of time that Tenant is in Default under any provision of this Lease; or 
 (ii) if Tenant has
been in Default under any provision of this Lease three or more times, whether or not the Defaults are cured, during the 12 month period immediately prior to the date that Tenant intends to exercise the Extension Right, whether or not the Defaults
are cured. 
 28.5 No Extensions. The period of time within which the Extension Right may be exercised shall not be extended
or enlarged by reason of Tenant’s inability to exercise the Extension Right. 
 28.6 Termination. The Extension Right
shall, at Landlord’s option, terminate and be of no further force or effect even after Tenant’s due and timely exercise of the Extension Right, if, after such exercise, but prior to the commencement date of the Extension Term,
(i) Tenant fails to timely cure any Default by Tenant under this Lease; or (ii) Tenant has Defaulted three or more times during the period from the date of the exercise of the Extension Right to the date of the commencement of the
Extension Term, whether or not such Defaults are cured. 
 ARTICLE 29 

RIGHT OF FIRST OFFER 

29.1 Tenant’s Right of First Offer. After the initial lease-up of the entire Building, Tenant shall have a one-time Right
of First Offer to lease any space (“Offer Space”) in the Building subject to the right of Foundation Medicine after initial lease-up of the Building (and to the extent any space remains vacant after September 1, 2015)
and subject to the right of Landlord to extend or renew any then current lease (or enter into a new lease with the same tenant even if no extension or renewal rights are contained in the current lease) and subject to the following terms and
conditions: 
 (a) Landlord shall give notice (“Offer Notice”) to Tenant of the availability (or
anticipated availability) of such space, setting forth the terms and conditions on which Landlord would lease such space to Tenant which terms shall include rent at the Market Rate. The term of the lease for the Offer Space shall be co-terminus with
the Term for the Premises provided that there is at least five (5) years of unexpired Term remaining in the Base Term or Extension Term. Otherwise the term pertaining to the Offer Space shall be five (5) years unless a longer term is
requested by Tenant. Tenant shall have the right, exercisable by notice to Landlord given on or before the tenth (10th) Business Day after receipt of the Offer Notice to lease such space on
the terms and conditions set forth in the Offer Notice. If Tenant shall not elect to lease such space within the ten (10) Business Day period, Landlord shall be free to lease such space at any time and on any terms and conditions; provided
however, that if Landlord intends to lease the Offer Space at an amount equal to or less than 95% of the rent offered to Tenant in the Offer Notice or 

  
 52 








 
Landlord fails to lease the Offer Space within the twelve (12) month period following Tenant’s failure to elect or election not to lease such Offer Space, Landlord shall again offer the
Offer Space to Tenant pursuant to this Article 29 at such lower rent amount. The twelve (12) month deadline shall be extended as necessary if Landlord has commenced negotiations with a prospective tenant but not yet in good faith executed a
lease during the twelve (12) month period. 
 (b) The terms and provisions of Sections 28.3-28.6 shall be incorporated
into this Section and pertain to Tenant’s option to exercise its Right of First Offer as if originally stated herein. 
 ARTICLE 30

 MISCELLANEOUS 

30.1 Notices. All notices or other communications between the parties shall be in writing and shall be deemed duly given upon
delivery or refusal to accept delivery by the addressee thereof if delivered in person, or upon actual receipt if delivered by reputable overnight guaranty courier, addressed and sent to the parties at their addresses set forth above. Landlord and
Tenant may from time to time by written notice to the other designate another address for receipt of future notices. 
 30.2 Joint and
Several Liability. If and when included within the term “Tenant,” as used in this instrument, there is more than one person or entity, each shall be jointly and severally liable for the obligations of Tenant. 

30.3 Financial Information. Upon request from Landlord given not more than once in any twelve month period unless a Default
shall have occurred and remain outstanding, Tenant shall furnish Landlord with true and complete copies of Tenant’s most recent annual financial statements and Tenant’s most recent unaudited quarterly financial statements, in form
customarily prepared by Tenant. If Tenant becomes a “public company” and its financial information is publicly available, then the foregoing delivery requirements of this Section shall not apply. Such financial information shall be
provided subject to the requirement that Landlord agree to: (a) hold in confidence all such financial information and not disclose the financial information to third parties other than Landlord’s affiliates, attorneys, lenders and
consultants without the prior written consent of Tenant; (b) use the financial information solely in connection with this Lease; (c) treat the financial information with the same degree of care it uses to protect its own but in no event
with less than a reasonable degree of care; (d) reproduce the financial information solely to the extent necessary in connection with this Lease, with all such reproductions being considered confidential; and (e) disclose solely to its
employees or consultants on a need-to-know basis; provided, however, that (i) any such employees and consultants are bound by written obligations of confidentiality at least as restrictive as those set forth in this Lease, and
(ii) Landlord remains liable for the compliance of such employees and consultants with such obligations. 
 Landlord will not have
obligations of non-disclosure and non-use with respect to any portion of the financial information that Landlord can demonstrate, by clear and convincing evidence: (a) is generally known to the public at the time of disclosure or becomes
generally known through no wrongful act on the part of Landlord; (b) is in Landlord’s possession at the time of disclosure other than as a result of Landlord’s breach of any legal obligation; (c) becomes


  
 53 








 
known to Landlord through disclosure by sources other than Tenant having the legal right to disclose such financial information; or (d) is independently developed by Landlord without
reference to or reliance upon the financial information as evidenced by written records. 
 If Landlord is required by a governmental
authority or by order of a court of competent jurisdiction to disclose any of the financial information, Landlord will give Tenant prompt written notice thereof and Landlord shall take all reasonable and lawful actions to avoid or minimize the
degree of such disclosure. Landlord will reasonably cooperate with Tenant in any efforts to seek a protective order. 
 30.4
Recordation. Tenant agrees not to record this Lease, but upon request of either party, both parties shall execute and deliver a notice of this Lease in form appropriate for recording or registration, and if this Lease is terminated before
the Term expires, an instrument in such form acknowledging the date of termination. 
 30.5 Interpretation. The normal rule of
construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of this Lease or any exhibits or amendments hereto. Words of any gender used in this Lease shall be held and
construed to include any other gender, and words in the singular number shall be held to include the plural, unless the context otherwise requires. The captions inserted in this Lease are for convenience only and in no way define, limit or otherwise
describe the scope or intent of this Lease, or any provision hereof, or in any way affect the interpretation of this Lease. 
 30.6
Not Binding Until Executed. The submission by Landlord to Tenant of this Lease shall have no binding force or effect, shall not constitute an option for the leasing of the Premises, nor confer any right or impose any obligations upon
either party until execution of this Lease by both parties. 
 30.7 Limitations on Interest. It is expressly the intent of
Landlord and Tenant at all times to comply with applicable law governing the maximum rate or amount of any interest payable on or in connection with this Lease. If applicable law is ever judicially interpreted so as to render usurious any interest
called for under this Lease, or contracted for, charged, taken, reserved, or received with respect to this Lease, then it is Landlord’s and Tenant’s express intent that all excess amounts theretofore collected by Landlord be credited on
the applicable obligation (or, if the obligation has been or would thereby be paid in full, refunded to Tenant), and the provisions of this Lease immediately shall be deemed reformed and the amounts thereafter collectible hereunder reduced, without
the necessity of the execution of any new document, so as to comply with the applicable law, but so as to permit the recovery of the fullest amount otherwise called for hereunder. 

30.8 Choice of Law. Construction and interpretation of this Lease shall be governed by the internal laws of the state in which
the Premises are located, excluding any principles of conflicts of laws. 
 30.9 Time. Time is of the essence as to the
performance of Tenant’s obligations under this Lease. 

  
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 30.10 OFAC. Tenant, and all beneficial owners of Tenant, are currently (a) in
compliance with and shall at all times during the Term of this Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive
order, or regulation relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of this Lease be listed on, the Specially Designated Nationals and Blocked Persons List maintained
by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or entity with whom a U.S. person is prohibited from
conducting business under the OFAC Rules. 
 30.11 Incorporation by Reference. All exhibits and addenda attached hereto are
hereby incorporated into this Lease and made a part hereof. If there is any conflict between such exhibits or addenda and the terms of this Lease, such exhibits or addenda shall control. 

30.12 Entire Agreement. This Lease, including the exhibits attached hereto, constitutes the entire agreement between Landlord
and Tenant pertaining to the subject matter hereof and supersedes all prior and contemporaneous agreements, understandings, letters of intent, negotiations and discussions, whether oral or written, of the parties, and there are no warranties,
representations or other agreements, express or implied, made to either party by the other party in connection with the subject matter hereof except as specifically set forth herein. 

30.13 No Accord and Satisfaction. No payment by Tenant or receipt by Landlord of a lesser amount than the monthly installment of
Base Rent or any Additional Rent will be other than on account of the earliest stipulated Base Rent and Additional Rent, nor will any endorsement or statement on any check or letter accompanying a check for payment of any Base Rent or Additional
Rent be an accord and satisfaction. Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such Rent or to pursue any other remedy provided in this Lease. 

30.14 Hazardous Activities. Notwithstanding any other provision of this Lease, Landlord, for itself and its employees, agents
and contractors, reserves the right to refuse to perform any repairs or services in any portion of the Premises which, pursuant to Tenant’s routine safety guidelines, practices or custom or prudent industry practices, require any form of
protective clothing or equipment other than safety glasses. In any such case, Tenant shall contract with parties who are acceptable to Landlord, in Landlord’s reasonable discretion, for all such repairs and services, and Landlord shall, to the
extent required, equitably adjust Tenant’s Share of Operating Expenses in respect of such repairs or services to reflect that Landlord is not providing such repairs or services to Tenant. 

30.15 REIT/UBTI. The Landlord and the Tenant hereby agree that it is their intent that all minimum rent and all other additional
rent and any other rent and charges payable to the Landlord under this lease (hereinafter individually and collectively referred to in this Section as “Rent”) shall qualify as “rents from real property” within the
meaning of Sections 512(b)(3) and 856(d) of the Internal Revenue Code of 1986, as amended, (the “Code”) and the U.S. Department of the Treasury Regulations promulgated thereunder (the “Regulations”).
In the event that (i) the Code or the Regulations, or interpretations thereof by the Internal Revenue Service contained in revenue rulings or other similar public pronouncements, shall be changed so that any Rent no longer so


  
 55 








 
qualifies as “rent from real property” for purposes of either said Section 512(b)(3) or Section 856(d) or (ii) the Landlord, in its sole discretion, determines that there
is any risk that all or part of any Rent shall not qualify as “rents from real property” for the purposes of either said Sections 512(b)(3) or 856(d), such Rent shall be adjusted in such manner as the Landlord may require so that it will
so qualify; provided, however, that any adjustments required pursuant to this Section shall be made so as to produce the equivalent (in economic terms) Rent as payable prior to such adjustment and shall not materially adversely affect the operations
of Tenant in the Premises. The parties agree to execute such further commercially reasonable instrument as may reasonably be required by the Landlord in order to give effect to the foregoing provisions of this Section. 

30.16 Quiet Enjoyment. So long as Tenant is not in Default under this Lease, Tenant shall, subject to the terms of this Lease,
at all times during the Term, have peaceful and quiet enjoyment of the Premises against any person claiming by, through or under Landlord. 

30.17 Prorations. All prorations required or permitted to be made hereunder shall be made on the basis of a 360 day year and 30
day months. 
 30.18 Rules and Regulations. Tenant shall, at all times during the Term and any extension thereof, comply with
all reasonable rules and regulations at any time or from time to time established by Landlord covering use of the Premises and the Project. The current rules and regulations are attached hereto as Exhibit J. If there is any conflict
between said rules and regulations and other provisions of this Lease, the terms and provisions of this Lease shall control. Furthermore, during the performance of Tenant’s Work, if there is any conflict between said rules and regulations and
the Tenant Design and Construction Guidelines attached hereto as Exhibit H, the terms and provisions of the Tenant Design and Construction Guidelines shall control. Landlord shall not have any liability or obligation for the breach of
any rules or regulations by other tenants in the Project and shall not enforce such rules and regulations in a discriminatory manner. 

30.19 Security. Landlord and Tenant acknowledge and agree that security devices and services, if any, while intended to deter
crime may not in given instances prevent theft or other criminal acts and that Landlord is not providing any security services with respect to the Premises and that Tenant is not providing any security services with respect to areas outside of the
Premises. Tenant agrees that, except to the extent caused by the negligence or willful misconduct of Landlord or any Landlord Party, Landlord shall not be liable to Tenant for, and Tenant waives any claim against Landlord with respect to, any loss
by theft or any other damage suffered or incurred by Tenant in connection with any unauthorized entry into the Premises or any other breach of security with respect to the Premises. Tenant shall be entitled to install and maintain security devices
and services as it deems appropriate within the Premises, and Landlord acknowledges that the scope of such security devices and services may include surveillance and monitoring of areas outside of the Premises provide that such devices do not affect
the rights and use and enjoyment of other tenants in the Building. Tenant shall be solely responsible for the personal safety of Tenant’s officers, employees, agents, contractors, guests and invitees while any such person is in, on or about the
Premises and/or the Project. Tenant shall at Tenant’s cost obtain insurance coverage to the extent Tenant desires protection against such criminal acts. 

  
 56 








 30.20 Force Majeure. Neither party shall be responsible or liable for delays in the
performance of its obligations hereunder (other than monetary obligations) when caused by, related to, or arising out of acts of God, sinkholes or subsidence, strikes, lockouts, or other labor disputes, embargoes, quarantines, weather, national,
regional, or local disasters, calamities, or catastrophes, inability to obtain labor or materials (or reasonable substitutes therefor) at reasonable costs or failure of, or inability to obtain, utilities necessary for performance, governmental
restrictions, orders, limitations, regulations, or controls, national emergencies, delay in issuance or revocation of permits, enemy or hostile governmental action, terrorism, insurrection, riots, civil disturbance or commotion, fire or other
casualty, and other causes or events beyond the reasonable control of such party (“Force Majeure”). 
 30.21
Brokers. Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent or other person in connection with this transaction and that no broker brought about this transaction, other than the Brokers
listed in Section 1.1 hereof. Landlord and Tenant each hereby agree to indemnify and hold the other harmless from and against any claims by any broker, other than the Brokers named in Section 1.1, claiming a commission or other form of
compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this leasing transaction. Landlord will be responsible to pay the commissions due to the named Brokers pursuant to a separate agreement. 

30.22 Severability. If any clause or provision of this Lease is illegal, invalid or unenforceable under present or future laws,
then and in that event, it is the intention of the parties hereto that the remainder of this Lease shall not be affected thereby. It is also the intention of the parties to this Lease that in lieu of each clause or provision of this Lease that is
illegal, invalid or unenforceable, there be added, as a part of this Lease, a clause or provision as similar in effect to such illegal, invalid or unenforceable clause or provision as shall be legal, valid and enforceable. 

[Signatures on next page] 

  
 57 








 IN WITNESS WHEREOF, Landlord and Tenant have executed this Lease as of the day and year
first above written. 
  

			
	 TENANT:
  

BLUEBIRD BIO, INC.,
 a Delaware corporation

		
	By:	 	/s/ Nick Leschly
	Name:	 	Nick Leschly
	Title:	 	 Chief Executive Officer

	
	 LANDLORD:
  

150 SECOND STREET, LLC,
 a Delaware limited liability
company

		
	By:	 	/s/ Shawn Hurley
		 	Shawn Hurley, Manager
		
	By:	 	/s/ Mats Johansson
		 	Mats Johansson, Manager



  
 58 








 EXHIBIT A TO LEASE 

PLAN OF PREMISES, STORAGE SPACES AND SHARED SPACES 

(Attached) 

  
 A-1 








 



 

  








 



 

  








 



 

  








 



 

  








 



 

  








 EXHIBIT B TO LEASE 

DESCRIPTION OF PROJECT 
 That
certain parcel of land with the buildings thereon situated in Cambridge, Middlesex County, Massachusetts being bounded and described as follows: 
 65
Bent Street, Cambridge, Massachusetts 
  

			
	            WESTERLY	  	on Second Street, two hundred (200) feet;
	            NORTHERLY	  	on Charles Street, three hundred (300) feet;
	            EASTERLY	  	on land of owners unknown, two hundred (200) feet;
	            SOUTHERLY	  	on Bent Street, three hundred (300) feet.

 Containing 60,000 square feet of land, any or all of said measurements being more or less. 

Subject to that certain Ground Lease dated November 12, 2010 by and between Bent Associates Limited Partnership, a Massachusetts limited partnership, as
ground lessor, and 150 Second Street, LLC, a Delaware limited liability company, as ground lessee, notice of which Ground Lease is recorded with the Middlesex County South District Registry of Deeds in Book 55812, Page 1. 

Being the same premises conveyed by Quitclaim Deed dated December 26, 1985 and recorded with said Deeds in Book 16676, Page 105. 

  
 B-1 








 EXHIBIT C TO LEASE 

ACKNOWLEDGMENT OF LEASE COMMENCEMENT DATE 

This ACKNOWLEDGMENT OF LEASE COMMENCEMENT DATE is made this
             day of                     ,
            , between 150 SECOND STREET, LLC, a Delaware limited liability company (“Landlord”), and
                            , a
             corporation (“Tenant”), and is attached to and made a part of the Lease dated
                ,              (the “Lease”), by and between Landlord and
Tenant. Any initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 
 Landlord and Tenant
hereby acknowledge and agree, for all purposes of the Lease, that the Lease Commencement Date of the Base Term of the Lease is
                    ,              and the termination date of the Base
Term of the Lease shall be midnight on                     ,             .
The Rent Commencement Date is                     ,             . In
case of a conflict between the terms of the Lease and the terms of this Acknowledgment of Commencement Date, this Acknowledgment of Lease Commencement Date shall control for all purposes. 

IN WITNESS WHEREOF, Landlord and Tenant have executed this Acknowledgment of Lease Commencement Date to be effective on the date first above
written. 
  

			
	 TENANT:
  

                          
                                         
                 ,
 a
                     corporation

		
	By:	 	 
	Its:	 	 
	  
 LANDLORD:

 
 150 SECOND STREET, LLC,

a Delaware limited liability company

		
	By:	 	 
	Name:	 	 
	Title:	 	 



  
 C-1 








 EXHIBIT D TO LEASE 

RENT CERTIFICATE 
 150 Second
Street, LLC 
 c/o Skanska USA Commercial Development Inc. 
 253
Summer Street 
 Boston, MA 02210 
  

	 	Re:	Lease dated as of                      by and between Rivertech Associates II, LLC
(“Landlord”), and Bluebird Bio, Inc. (“Tenant”), pertaining to the                  floor consisting of
                 rentable square feet of the building (collectively, the “Premises”) located at 840 Memorial Drive, Cambridge, Massachusetts
(“Lease”). 

 The undersigned hereby certifies, represents and warrants to 150 Second Street, LLC and its
successors, assigns, affiliates and lenders (together, the “New Landlord”), as follows and acknowledges that this certification, representation and warranty are being relied upon by the New Landlord in connection with provisions of
Section 4.2 of the Lease Agreement dated as of                     , 2013 by and between New Landlord and Tenant pertaining to certain
premises located at 150 Second Street, Cambridge, Massachusetts: 
 1. Tenant has previously delivered a true, accurate and complete copy of
the Lease to the New Landlord and there have been no amendments, modifications, side letters or other agreements relating to the Lease since such delivery. The Lease is in full force and effect. 

2. The term of the Lease expires on
                    . 
 3.
Tenant has paid to Landlord the monthly fixed rent of $                 and monthly additional rent for operating costs and taxes of
$                 due under the Lease through the period ended
                , 20__. 
 6. Tenant is not entitled
to, and has made no agreement(s) with Landlord concerning, free rent, partial rent, rebate of rent payments, credit or offset or deduction in rent, or any other type of rental concession, including, without limitation, lease support payments, lease
buy-outs, or rental concessions pertaining to any unfunded tenant improvement allowance. 
 7. Tenant has neither assigned its interest
under the Lease, by operation of law or otherwise, nor entered into any sublease, concession agreement or license pertaining to the Premises or any portion thereof. 

8. Tenant has no option to reduce the Premises or no right to terminate the Lease prior to the stated expiration date other than as
specifically set forth in the Lease with respect to casualty and condemnation. The Landlord has no right to recapture any portion of the Premises prior to the stated expiration date other than as specifically set forth in the Lease with respect to
casualty and condemnation. 

  
 D-1 








 9. [If a Memorial Drive Rent Savings Event has occurred, in lieu of Sections 4, 5 or 6 above,
as the case may be, insert in substantially the following form : Tenant has entered into a sublease pertaining to the Premises. The monthly base rent and escalations due to Landlord is
$                 for the period ended                 . The documented out
of pocket transaction costs to Tenant in connection with the sublease is $                . The rent payable under the sublease is
$                 for the period ended                 . 

Or in the alternative, as the case may be: Tenant’s rent obligations under the Lease have terminated or been reduced by virtue of
                 (for example, lease termination agreement). The aggregate amount of rent savings under the Lease through the original expiration date of the term
of the Lease is $                . The documented out of pocket transaction costs to Tenant in connection with the (lease termination agreement) is
$                . ] 
 Executed under seal as of the
         day of                 , 20     . 

 

			
	 BLUEBIRD BIO, INC.,
 a
Delaware corporation

		
	By:	 	 
	Name:	 	 
	Title:	 	 



  
 D-2 








 EXHIBIT E TO LEASE 

BASE BUILDING SPECIFICATIONS 

  
 E-1 










			
	



	 	3.5.13

  

 Base-Building Core & Shell Definition 

150 Second Street – Cambridge, MA 
 1.
GENERAL 
 Landlord is to deliver building for Use Group B and S-2, using Type I-B Construction in accordance with 780 CMR
Massachusetts State Building Code – 8th Edition. 
  

	 	A.	Basement Level – 12’-2” Floor-to-floor height. 

  

	 	B.	Ground Floor – 14’-8” Floor-to-floor height. 

  

	 	C.	Second Floor – 14’-8” Floor-to-floor height. 

  

	 	D.	Third Floor – 14’-8” Floor-to-floor height. 

  

	 	E.	Total area is approximately 123,210 RSF subject to final measurement. 

  

	 	F.	Structure designed to accommodate finish ceiling height of 9’-4” AFF. 

  

	 	G.	Slab to underside of beam dimension is 11’ typical with ability for utilities to be run though open webbed joists. 

  

	 	H.	General column spacing is 32’ x 45’. 

  

	 	I.	Building/Core and Shell Project designed to achieve LEED Gold Certification (NC). 

 2. FOUNDATIONS
AND SLAB-ON-GRADE 
  

	 	A.	Foundations consist of spread footings with a perimeter foundation wall. Basement slab consists of 5” reinforced concrete slab-on-grade. 


 

	 	B.	All foundation, slab-on-grade, and slabs-on-deck concrete will be controlled and tested in accordance with applicable building codes and standards. Concrete compressive strengths will be as required to meet structural
requirements, but no less than 4,000 psi. 

  

	 	C.	Concrete reinforcing steel conforms to ASTM 615. 

  

	 	D.	Welded wire mesh conforms to ASTM 185. 

  

	 	E.	Slab-on-grade designed for a 100 psf live load. 

 3. STRUCTURE 

 

	 	A.	The structure has been designed with the following live loads: 

  

	 	1.	Wind and seismic loads in accordance with State Building Code. 

  

	 	2.	Tenant area floors – 100 psf. 

  

	 	3.	Mechanical equipment rooms – 150 psf 

  

	 	4.	Penthouse Roof –20 psf Minimum Live Load and in accordance with governing building codes, plus allowances for specific snow drifting and equipment loads. 


 

	 	B.	The structure consists of an internally-braced steel frame supporting composite 3” metal deck with 4  1⁄2 “ NW concrete
fill at tenant floors, reinforced with 6 x 6 W.W.F. 


  
 



 
 E-2 










			
	



	 	3.5.13

  


	 	C.	All steel is ASTM A36, A572 grade 50, A992 grade 50, A500 grade B, or as required. All shop and field-welded connections are welded in accordance with AWS standards. Bolted field connections have been made with  3⁄4” diameter A325 high-strength bolts, minimum. 

  

	 	D.	Floor deck at tenant floors consists of minimum 18 gauge steel or as engineered. All metal deck will conform to the Steel Deck Institute’s Code of Recommended Standard Practice. 


 

	 	E.	Composite steel floor deck concrete cover at floors have a minimum compressive strength of 4,000 psi and reinforced with welded wire mesh. 


 

	 	F.	Structure is fireproofed where required by the Commonwealth of Massachusetts Building Code. 

  

	 	G.	Fire exit stairs are standard steel pan stair assemblies with painted steel handrails and concrete treads. 

  

	 	H.	Miscellaneous iron items (elevator sill angles, ladders, railings, access platforms, stairs for accessing all equipment in compliance with OSHA and applicable codes, loose lintels, expansion plates, toilet partition
support frames, etc.) are provided as needed. 

 4. ROOFING AND WATERPROOFING 

 

	 	A.	Roofing system is a loose-laid, mechanically-fastened or fully adhered, single-ply membrane, TPO type similar to Carlisle. 

  

	 	B.	Roof insulation is extruded polystyrene board similar to Styrofoam by Dow, conforming to requirements of the Massachusetts State Energy Code and is acceptable for use with the roofing membrane specified.


  

	 	C.	Roof accessories such as bonding adhesive, splicing cement, lap sealant, tape, water cut-off mastic, etc., are compatible with the roofing membrane specified. Typical roof penetrations are flashed with material matching
the roof system. 

  

	 	D.	Metal flashing has been provided and a perimeter coping/gravel stop is anodized extruded or painted brake-formed aluminum. 

  

	 	E.	Elevator pits are waterproofed as required. 

  

	 	F.	Compatible roof walkway pads by the roofing manufacturer have been provided for base building equipment access and servicing. 

  

	 	G.	Base building includes a prescribed method for exterior window. Equipment to be provided by property management personnel. 


5. EXTERIOR WALLS 
  

	 	A.	The Building is clad with a combination of cementitious fiberboard, strip windows, curtain wall and composite metal panels. All glass is new energy efficient “low E” glass. 


  
 



 
 E-3 










			
	



	 	3.5.13

  


	 	B.	Entrance doors are aluminum storefront doors. BOH doors are painted hollow metal. 

  

	 	C.	Loading dock exterior doors are electronically operated, high-cycle aluminum doors by Rytec or similar. 

 6.
INTERIOR FINISHES 
  

	 	A.	Main entrance floor finish is terrazzo flooring. Lobby walls are finished with a combination of wood paneling/glass/resin synthetic panel feature wall and painted drywall and ceilings. 


 

	 	B.	Core Toilet floors are ceramic tile or similar. Marble thresholds are provided at door openings where ceramic tile abuts other floor finishes. All toilet room wet walls are covered with ceramic tile or similar up to
ceiling. Paint is provided for the remaining walls. Toilet ceilings are acoustical tegular tile suspended ceilings with an exposed suspension grid, or drywall. Lavatory counters are polished granite or similar with under mounted sinks. All toilet
spaces throughout the building are of the same color and level of finish. Automatic flushometers and touchless faucets have been installed on all lavoratories, water closets, and urinals. 


 

	 	C.	Door frames are hollow metal (cold-formed steel). Solid core, wood veneer doors are provided for common area amenities such as toilet rooms. Painted hollow metal doors are provided for Base Building service areas. All
doors and hardware comply with regulations of the Massachusetts Architectural Access Board and The Americans with Disabilities Act. 

  

	 	D.	Landlord has provided the Base Building mechanical rooms, electrical rooms, telephone/data riser closets and janitorial closets in core area on typical floors and ground floor. 


 

	 	E.	Inside face of typical exterior walls consists of the back of the façade cladding system with insulation, fireproofed as required by code. 


 

	 	F.	Lobby and Base Building interior lighting consists of architecturally specified efficient lighting. 

  

	 	G.	Typical stair finishes include concrete floors and treads, painted steel risers and rails, primed and painted drywall surfaces. 


7. SPECIALTIES & EQUIPMENT 
  

	 	A.	Building Directory’s will be provided by Base Building. Base Building will specify and install signage required by code, including City of Cambridge Inspectional Services and Fire Dept. for Base Building portion of
construction. 

  

	 	B.	Metal toilet partitions are steel panels with brushed stainless steel finish, and floor-mounted. 


  
 



 
 E-4 










			
	



	 	3.5.13

  


	 	C.	Toilet room accessories, brushed stainless steel, Bobrick Co., or equal: recessed paper towel dispenser; toilet paper holders; soap dispensers; grab bars. 


8. VERTICAL TRANSPORTATION 
  

	 	A.	Two (2) gearless, standard elevators based on the following quantities, speeds and capacity: One (1) 3,500 #, 200fpm passenger elevator serving Basement through
3rd floors and One (1) 4,000, 200fpm, double-sided combination service / passenger elevator serving Basement through penthouse floors. Interior cab finishes are similar in quality and context
to ground floor lobby. 

 9. PLUMBING 
  

	 	A.	Domestic water system supplied by dual metered service from public water mains. Piping is type “L” copper. Two (2) 125 gallon, gas-fired domestic water heaters are provide re-circulating hot water
to accommodate core toilet rooms and tempered water risers. 

  

	 	B.	Stormwater is reclaimed from a portion of the roof; collected in an underground storage tank and reused for toilet and urinal flushing to supplement potable water requirement. Overflow from tank and the remainder of the
roof discharges to a storm infiltration system. 

  

	 	C.	Low pressure gas service provided to all base building equipment. Gas riser is sized with additional capacity to supply tenant provided generators. 


 

	 	D.	Typical toilet rooms on floors 1-3 have fixture count as required by code. All water closets and urinals are wall hung to facilitate floor cleaning. All fixtures are “low-flow” type, hands-free.
Lavatory sinks are under mounted and have metered and motion sensor operated faucet controls with hot water flow restrictors. 

  

	 	E.	Showers are provided on the first floor. 

  

	 	F.	Non-potable cold water risers are provided to supply non-potable connection at each floor. 

  

	 	G.	Clear water waste receivers aree provided at each floor to accept RO reject water, condensate and similar clean water. This water can also be collected in the above-mentioned tank for reuse. 


 

	10.	FIRE PROTECTION SYSTEM 

  

	 	A.	Fire protection is fed from a 6” service from the public water main. An in-line, vertical fire pump feeds two (2) 6” combined standpipes, to provide pressure for the sprinkler system. 


 

	 	B.	Hose connections for Fire Department use will be provided as required by code for base building only. Piping will be black steel pipe schedule 10 for pipe 2 1⁄2” and larger and schedule 40 for pipe 2” and smaller. All piping, valves and equipment is UL-Listed and labeled. Tamper switches are provided on all control valves. 


  
 



 
 E-5 










			
	



	 	3.5.13

  


	 	C.	Automatic sprinkler system is supplied from the combination sprinkler/standpipe risers in each stair. The sprinkler systems on each floor is connected to the riser in each stair. All occupied space in the building is
fully sprinklered using upright sprinkler heads, at a density in accordance with code. Sprinkler coverage is designed for light hazard protection in core and common areas, ordinary hazard group 1 protection in mechanical and storage areas, and up to
ordinary hazard group 2 in tenant lab areas. 

  

	11.	HEATING, VENTILATING AND AIR CONDITIONING 

  

	 	A.	The cooling system includes a chilled water plan consisting of three (3) 300-ton water-cooled centrifugal chillers, associated pumps, and distribution to two (2) custom manufactured variable volume air
handling units with a nominal capacity of 82,000CFM. Heat is rejected to the atmosphere by two (2) 625-ton cooling towers equipped with whisper quiet fans. 

  

	 	B.	Heating is provided by hot water risers fed from four (4) 2,700-MBH gas-fired, condensing boilers. Valved branch lines on the hot water risers is provided to each floor for tenant use. 


 

	 	C.	Laboratory exhaust is provided by two (2) 82,000 CFM variable volume exhaust air handlers with energy recovery systems to transfer heat from the exhaust to the outside air entering the building. 


 

	 	D.	Space is provided for additional tenant dedicated air handlers, exhaust air handlers, cooling towers, boilers and chillers. 

  

	 	E.	Tenant supplemental cooling capacity is provided by secondary condenser water risers connected to the building’s cooling towers by 140 ton plate and frame heat exchanger providing approximately 45 tons of cooling
to each floor. 

  

	 	F.	Garage exhaust is equipped with a total capacity of 20,600CFM exhaust control with carbon monoxide sensors and VFD control. 

  

	 	G.	The Building Automation System is equipped with Direct Digital Control (DDC). The DDC system incorporates a complete graphics interface package to monitor and control all HVAC systems. The system is expandable to
include all tenant systems and equipment. 

  

	 	H.	One 660 gallon double wall fuel storage tank is provided to feed the life-safety emergency generator in the mechanical penthouse. 

  

	 	G.	Toilet areas have exhaust air systems maintaining an exhaust rate of 75CFM/fixture. 

  

	 	H.	Base building provides infrastructure for approximately 75 degrees Fahrenheit, dry bulb at 55% relative humidity during the cooling season and approximately 70 degrees Fahrenheit during the heating season; both based on
ASHRAE design conditions of the City of Boston. 

 OUTDOOR DESIGN CONDITIONS ( ASHRAE 1%) 

 

					
	A.	  	Summer:	  	91 F dry bulb
		  		  	88 degrees Farhrenheit dry bulb, 73 degree Farhrenheit wet bulb
	B.	  	Winter:	  	6 degrees Fahrenheit Dry Bulb



  
 



 
 E-6 










			
	



	 	3.5.13

  

 INDOOR DESIGN CONDITIONS 

 

					
	A.	  	Summer:	  	74 F dry bulb 50 % RH
	B.	  	Winter:	  	72 F dry bulb 20% RH


 VENTILATION 

Minimum Outside Air: In accordance with the Massachusetts State Building Code, 8th Edition 

 

			
	Anticipated occupancy:	  	7 people per 1000sf for office
		  	50 people per 1000sf for conference room
	Ventilation Rate:	  	1.7 CFM/sq ft


 INTERNAL HEAT GAIN 

 

			
	Occupants:	  	108sf/person (useable sf)
	Lighting	  	1.0 watts/useable sf
	Power	  	7 watts/useable sf


  

	 	G.	Outside air for ventilation is provided by four ventilation riser ducts stubbed into 1 location on each floor in accordance with current codes and ASHRAE standards. Ventilation and exhaust airflows for Tenant needs
shall be designed by Tenant designers. Available floor exterior static pressure allowance shall be 0.75”wc. 

  

	 	I.	Base Building mechanical equipment is provided with necessary acoustical vibration isolation as recommended by an independent acoustical consultant to achieve a Sound Transmission Class in accordance with code.


  

	12.	ELECTRICAL 

  

	 	A.	Base building service is a metered 3,000-amp 277/480V 3-phase, 4 wire electric service 

  

	 	B.	Each tenant floor is served by a separately unmetered 800-amp 277/480V 3-phase, 4 wire electric service capable of providing 12w/sf of tenant floor power 


 

	 	C.	Spare capacity is provided at the building switchgear for additional electric service as required. 

  

	 	D.	A 250 KW, diesel engine generator to accommodate base building life safety requirements is provided. 

  

	 	E.	One telephone/data closet per floor is provided in base building for tenant installed risers and distribution cabling, consisting of three (3) riser sleeves at 5” each 


 

	 	F.	A fully addressable code compliant fire alarm system is installed with sufficient power supplies and infrastructure capacity at the head end for the future tenant tie-in. The tenant is responsible for electronic release
devices and locking mechanisms at stair tower egress doors if the tenant intends to use stairwells for inter-floor travel. The tenant is to supply, install and coordinate all fire alarm notification and initiating devices within the tenant space
connected to base building systems. Base Building egress stairwell doors will be passage type, unlocked. 

  

	 	G.	 Fire alarm system includes a City of Cambridge Master Box, all front end equipment, common area ADA notification
and alarm initiating devices, elevator 



  
 



 
 E-7 










			
	



	 	3.5.13

  


	 	
recall, and terminal boxes on each floor for connection of tenant fire alarm and notification devices to the base building system. The fire alarm terminal cabinets shall be located in the
electrical closets. 

  

	 	H.	Base building security system provides building perimeter security with card readers and CATV. Tenant security system is to be designed by the tenant for its specific needs. Tenant will be responsible for system design,
distribution wiring and installing all the cameras, access control, and related appurtenances as part of TI. 

 —END—


  
 



 
 E-8 








 EXHIBIT F TO LEASE 

LANDLORD TENANT MATRIX 

  
 F-1 








 Skanska Commercial Development Inc 

150 Second Street 
 5.15.13 

Allocation of Responsibility Between Landlord and Tenant Work 
  

							
	 ELEMENT
	  	 DESCRIPTION
	  	 BASE
BUILDING
WORK
	  	 TENANT
WORK

				
	SITE IMPROVEMENTS:	  	Entrance Plaza, perimeter sidewalks, street trees, street lights and furniture in accordance with the Approved Project.	  	X	  	
				
		  	Telephone conduit from outside building into basement floor telephone room.	  	X	  	
				
		  	Cable/Data conduit from outside building into basement telephone room	  	X	  	
				
		  	Electrical Service to building	  	X	  	
				
		  	Gas Service to building for base building and tenant systems	  	X	  	
				
		  	Domestic sanitary sewer connection to street	  	X	  	
				
		  	Lab waste sanitary sewer connection from tenant pH room in basement floor to building drain.	  	X	  	
				
		  	Domestic and fire protection water service to building.	  	X	  	


  
 F-2 









							
	CODE COMPLIANCE:	  	Building construction in accordance with requirements of Massachusetts State Building Code, 8th edition (as amended, restated, or superseded as applicable)	  	X	  	X
				
	STRUCTURE:	  	Floor systems capable of supporting a live / partition load of 100 lbs. psf on all floors	  	X	  	
				
		  	14’8” Floor to floor heights, 12’ floor to floor height in B1	  	X	  	
				
		  	Floor construction to accommodate 100lbs/sf on floors 1 through 3. Penthouse floor construction to accommodate 150lbs/sf	  	X	  	
				
		  	Structural modifications to increase floor live load capacity	  		  	X
				
		  	Structural modifications to accommodate tenant specific openings including but not limited to shafts, risers, and interconnecting stairs	  		  	X
				
		  	Framed openings for base building supply air and tenant exhaust shafts	  	X	  	
				
		  	All catwalks and dunnage required to support and enable access to Base Building mechanical equipment.	  	X	  	
				
		  	All structural modifications, dunnage, catwalks and other requirements necessary to support and enable access to Tenant equipment in Penthouse	  		  	X


  
 F-3 









							
		  	Miscellaneous metal items such as brackets or supports and concrete housekeeping pads required for tenant supplied equipment	  		  	X
				
		  	Structural assemblies requiring fire-proofing to be sprayed with cementitious fireproofing system	  	X	  	X
				
	BUILDING ENVELOPE:	  	Environmentally responsible sustainable building design that achieves LEED Gold Certification.	  	X	  	
				
		  	Facade of aluminum and glass window wall, cementitious rain screen and metal panels, with thermally insulated glass including light-gauge metal stud back-up with insulation where required	  	X	  	
				
		  	Overhead coiling doors at loading dock and at parking garage entry	  	X	  	
				
		  	Acoustic roof screen to conceal tenant exhaust fans and standby generators	  	X	  	
				
		  	Architecturally integrated, enclosed mechanical penthouse with space for tenant mechanical equipment.	  	X	  	
				
		  	Any modifications to façade, penthouse or screen wall system necessary to accommodate tenant requirements, provided that any such modifications must be approved by Landlord.	  		  	X
				
	ROOFING:	  	TPO system with walking pads to all base building mechanical equipment.	  	X	  	


  
 F-4 









							
		  	Roofing penetrations for tenant equipment or systems, to be made in accordance with roofing manufacturer’s details and warranty requirements	  		  	X
				
		  	Walking pads to tenant special mechanical equipment.	  		  	X
				
	COMMON AREAS:	  	Entrance lobby with finishes that include stone, tile & carpet flooring, wood or stone wall accents, drywall and suspended ceilings and appropriate accent lighting.	  	X	  	
				
		  	Finished egress stairways and corridors as required for occupant circulation and emergency egress	  	X	  	
				
		  	Men’s and Women’s shower rooms located near first floor bathrooms	  	X	  	
				
		  	Exterior loading area with two truck bays with access and space for one rubbish dumpster	  	X	  	
				
		  	Loading Dock Lift (if required)	  		  	X
				
		  	Ground floor recycling room	  	X	  	
				
		  	Basement level parking area	  	X	  	
				
		  	Bike racks located in basement	  	X	  	
				
		  	Finished basement floor main electrical service rooms, water and fire pump room	  	X	  	
				
		  	Finished toilet rooms, janitor closets, telephone and electric closets, and egress stairways serving each floor.	  	X	  	


  
 F-5 









							
		  	Construction of code-required corridor system on each floor, including door packages, ready for Tenant finish if tenant occupies entire floor.	  		  	X
				
		  	Construction of and finish for common corridors and elevator lobbies on multi-tenant floors.	  	X	  	
				
		  	Rooftop mechanical penthouse and screened roof area for base building mechanical equipment. Rooftop expansion space allocated for tenant mechanical equipment in designated locations within the screen wall.	  	X	  	
				
		  	Doors and frames at common areas: hollow metal frames; hollow metal doors at service areas, solid core wood doors at other areas, and lever hardware	  	X	  	
				
		  	Doors, frames, and hardware to tenant areas	  		  	X
				
	ELEVATORS	  	One gearless passenger elevator with 3,500 lb. capacity	  	X	  	
				
		  	One gearless combination freight/passenger elevator with 4,000lb capacity	  	X	  	
				
		  	Dedicated shaft way for third elevator	  	X	  	
				
		  	Third Elevator if required	  		  	X
				
	WINDOW TREATMENT:	  	Supply and installation of building standard blinds for all windows	  		  	X
				
		  	Modifications to window wall system approved by Landlord	  		  	X


  
 F-6 









							
		  	Signage, lighting and other brand identity treatments approved by Landlord	  		  	X
				
	TENANT AREAS:	  	Construction of and finishes for corridors and elevator lobbies for single tenanted floors	  		  	X
				
		  	Light gauge framing, insulation & vapor barrier on inside face of exterior walls.	  	X	  	
				
		  	Interior wall furring and sills (if applicable) and drywall finish at perimeter walls.	  		  	X
				
		  	Interior drywall soffit at perimeter of building with blocking for building standard window treatments.	  		  	X
				
		  	Partitions, ceilings, flooring, painting, doors, millwork and all related finishes for office and laboratory build out within Tenant premises	  		  	X
				
	HVAC:	  	Processed condenser water system capable of providing 45 Tons per floor at 2.4 GMP per Ton per Floor	  	X	  	
				
		  	(2) Condenser Water Supply and Return Distribution Risers connected to a plate/frame heat exchanger with 2- 1⁄2” valves capped on floors
1 through 3 for tenant distribution and 1  1⁄2” valves capped in the basement on the east side of the building.	  	X	  	
				
		  	Condenser Water on-floor distribution	  		  	X


  
 F-7 









							
		  	Central Chilled Water Plant sized to provide cooling with 100% outside air at 1.7CFM per usable sf	  	X	  	
				
		  	Allotted space for future 150ton chiller to accommodate expansion of system to 2CFM per usable sf	  		  	X
				
		  	Processed Chilled Water system capable of providing 45 Tons per floor with energy recovery taken into account	  	X	  	
				
		  	Plate and Frame heat exchanger, associated piping and pumps to connect chilled water riser to existing chillers and/or future 150ton chiller	  		  	X
				
		  	(2) Processed Chilled Water Supply and Return Distribution Risers	  	X	  	
				
		  	Processed Chilled Water Supply and Return riser connection in penthouse to tenant provided chiller (if required)	  		  	X
				
		  	Excess Capacity in base building chiller plant to provide chilled water to each floor (capacity subject to chilled water on floor use)	  	X	  	
				
		  	Tenant Chiller for Tenant Process Chilled Water	  		  	X
				
		  	Penthouse air handling units capable of providing 1.7 CFM per usable sf. Vertical supply ducts sized to accommodate 2.0CFM stubbed out in (2) locations per floor	  	X	  	
				
		  	Additional AHU to exceed 1.7CFM/sf of supply	  		  	X


  
 F-8 









							
		  	General laboratory exhaust fans capable of exhausting 1.7 CFM per usable sf. Vertical exhaust ducts sized to accommodate 2.0CFM stubbed out in (2) locations per floor	  	X	  	
				
		  	Additional laboratory exhaust fans to exceed 1.7CFM/sf of exhaust	  		  	X
				
		  	All on-floor supply and exhaust distribution in tenant spaces	  		  	X
				
		  	Central Heating Plant consisting of condensing boilers supplying hot water to AHU’s and other shell and core heating elements.	  	X	  	
				
		  	Allotted space for future condensing boiler	  	X	  	
				
		  	Future boiler and associated piping and pumps to accommodate expansion of system to 2CFM per usable sf	  		  	X
				
		  	(2) Hot water supply and return distribution risers with 2- 1⁄2” valves capped on floors 1 through 3 for tenant distribution. 1  1⁄2” riser drops to basement level on the East side of the building.	  	X	  	
				
		  	All hot water supply and return on-floor distribution for tenant use	  		  	X
				
		  	Any additional mechanical equipment and/or any modifications to Base Building equipment to increase the mechanical capacity of the building.	  		  	X


  
 F-9 









							
		  	Ductwork, VAV boxes, registers and controls for HVAC in lobby spaces and core areas, including toilet exhaust system.	  	X	  	
				
		  	Supply and exhaust air distribution within the tenant space including all medium pressure and low pressure ducts, diffusers, registers, grilles, terminal volume control boxes, VAV boxes, fan powered units, reheat coils, baseboard
radiation and hot water piping.	  		  	X
				
		  	Toilet and/or shower ventilation requirements for additional tenant locker rooms and restrooms as required.	  		  	X
				
		  	Central DDC computerized energy management system for applicable core and shell system with expansion capacity for tenant fit out systems.	  	X	  	
				
		  	Temperature controls within tenant space, and links to base building system.	  		  	X
				
		  	Dedicated kitchen exhaust system	  		  	X
				
		  	All components of tenant exhaust systems, including fume hoods, floor distribution ductwork, specialty high corrosive system ducts and dedicated exhaust fans, controls, equipment dunnage and sound attenuation.	  		  	X
				
		  	Dedicated air handler, additional cooling, additional heating and associated ductwork, equipment and controls if required for a Tenant Animal Care Facility.	  		  	X


  
 F-10 









							
		  	Specialized tenant systems and equipment including supplemental or spot cooling, steam boilers, dedicated rated exhaust for H2 or H3 storage rooms, air and vacuum systems and all related HVAC equipment.	  		  	X
				
		  	Additional sound attenuation necessary to ensure tenant’s equipment complies with local noise regulations.	  		  	X
				
		  	Carbon Monoxide Monitored garage exhaust system	  	X	  	
				
		  	Fuel oil storage tank, transfer pumps and distribution piping for Base Building life safety emergency generator	  	X	  	
				
		  	Fuel oil system tenant provided stand-by generator.	  		  	X
				
		  	BTU Meters connected to BAS for hot, condenser, and processed chilled water at floor connections	  		  	X
				
		  	Air monitoring flow stations connected to BAS for exhaust	  		  	X
				
		  	Air monitoring flow stations connected to BAS for supply (at Floor take-offs or at terminal units if required by tenant)	  		  	X
				
	GAS:	  	Gas service capable of providing low-pressure (10” w.g. ) service.	  	X	  	
				
		  	Gas piping for Base Building equipment.	  	X	  	


  
 F-11 









							
		  	6” Gas service brought to tenant non-roofed penthouse for tenant provided generator capable of providing 8000 cfh (tenant premises to dictate allocation)	  	X	  	
				
		  	Gas Sub-meter for tenant use	  		  	X
				
		  	Gas connection to tenant generator	  		  	X
				
		  	Any and all tenant required gas service and distribution for on-floor use	  		  	X
				
	PLUMBING:	  	Domestic water service, with back-flow prevention and duplex booster.	  	X	  	
				
		  	(2) Gas Fed Boilers providing hot water to restrooms and tempered water risers	  	X	  	
				
		  	Hot water supply and return risers and distribution to restrooms	  	X	  	
				
		  	Core and Restroom plumbing and fixtures to meet code requirements	  	X	  	
				
		  	(1) 4” Domestic Cold water riser with 1” connections valved and capped on floors 1 through 3	  	X	  	
				
		  	Water Sub-meter and on-floor distribution of domestic cold water	  		  	X
				
		  	Hot water plumbing including heaters, boilers, distribution and associated equipment for tenant use	  		  	X
				
		  	(2) 2” Tempered Water Risers valved and capped on floors 1 through 3 providing 70-90 degree water	  	X	  	
				
		  	Tempered Water Sub-meter and on-floor distribution for tenant use	  		  	X


  
 F-12 









							
		  	(2) 3” Nonpotable Water risers fed from 2 booster pumps stubbed out on floors 1 through 3	  	X	  	
				
		  	Nonpotable Water submeter and on-floor distribution	  		  	X
				
		  	Installation of Tenant’s non-potable/potable water heaters.	  		  	X
				
		  	Tenant metering, sub metering, distribution and backflow prevention at laboratory connections.	  		  	X
				
		  	Waste and vent risers for tenant non-lab waste	  	X	  	
				
		  	Connection to non-lab waste and vent	  		  	X
				
		  	Shaft Space for lab waste and vent risers	  	X	  	
				
		  	Lab waste and vent risers for tenant use	  		  	X
				
		  	Domestic sanitary sewer, storm, and water to/from city	  	X	  	
				
		  	Roof and canopy storm drains	  	X	  	
				
		  	Production and distribution of clean steam including fuel source.	  		  	X
				
		  	Steam generator, fuel source, floor by floor humidification associated steam piping and reducing stations.	  		  	X
				
		  	All non-base building plumbing including kitchen, cafeteria and specialized equipment.	  		  	X


  
 F-13 









							
		  	Reserved, allocated space in basement for tenant’s acid neutralization system	  	X	  	
				
		  	Acid waste neutralization equipment, lifting stations and laboratory waste lines including distribution, pumps, and risers.	  		  	X
				
		  	Manifolds, piping, floor drains, equipment and other requirements for laboratory gases, compressed air, vacuum systems and RO/DI water systems. Distributed vertical utility chases are provided.	  		  	X
				
		  	Waste stacks to receive base building and tenant clear water wastes (e.g., a.c. condensate, RO reject).	  	X	  	
				
	ELECTRICAL:	  	Base building electric metered by Nstar at main switchboard	  	X	  	
				
		  	Tenant electric metered by Nstar on tenant floor	  		  	X
				
		  	Tenant submeter for any specialized and/or processed loads (data center, etc.)	  		  	X
				
		  	Life safety lighting and other “Legally Required” emergency power systems.	  	X	  	
				
		  	Automatic transfer switch for emergency and egress lighting	  	X	  	X
				
		  	Building electrical service to provide two 3,000 Ampere 480/277 Volt, 3 phase, 4 wire via main switchboards in main electrical room.	  	X	  	


  
 F-14 









							
		  	Allocation of approximately 12 watts/sf for tenant distribution with 15 watts/sf for lab area and 5 watts/sf for office area based on 70%/30% lab to office ratio% office	  	X	  	
				
		  	(2) 4” Conduits from unmetered switchboard in basement to 800AMP unmetered wireway	  	X	  	
				
		  	Conductor from basement switchboard to 800 AMP wireway in each floor’s electric room	  		  	X
				
		  	CT cabinet, utility meter, high voltage, low voltage and distribution for tenant power	  		  	X
				
		  	All power for any and all systems within tenant space	  		  	X
				
		  	Lighting & receptacles serving core areas.	  	X	  	
				
		  	Building Exterior lighting package.	  	X	  	
				
		  	Exterior and Interior Tenant Signage lighting package	  		  	X
				
		  	Diesel fuel life safety generator to provide emergency power for MA code-required egress lighting, fire alarm systems, common area emergency egress lighting and exit signs, capacity to serve emergency egress and exit lighting in
tenant areas and lab exhaust fans.	  	X	  	
				
		  	Emergency Transfer switch(s) capable of providing power to code required emergency equipment.	  	X	  	


  
 F-15 









							
		  	Back-up generator and systems, including transfer switch, distribution, controls and associated appurtenances	  		  	X
				
		  	Emergency egress and exit lighting in core areas.	  	X	  	
				
		  	Emergency egress and exit lighting fixtures in tenant area, connected to Base Building life safety emergency generator.	  		  	X
				
	FIRE PROTECTION:	  	Sprinkler service entrance including fire department connection, alarm valve, backflow protection and standpipe in each stair.	  	X	  	
				
		  	Fire Pump and all related controls	  	X	  	
				
		  	Core and stair area sprinkler heads and piping.	  	X	  	
				
		  	Flow control valve station in stair at each floor.	  	X	  	
				
		  	Primary sprinkler distribution on each floor.	  	X	  	
				
		  	All run outs, drops, heads and related equipment within tenant premises.	  		  	X
				
		  	All run outs, drops, heads and related equipment within unleased and unoccupied space within the building as required to obtain a building occupancy permit.	  	X	  	
				
		  	Special extinguishing systems.	  		  	X
				
		  	Fire Extinguisher Cabinets in core area with appropriate Fire Extinguisher	  	X	  	


  
 F-16 









							
		  	Fire Extinguisher Cabinets in tenant area (building standard) with appropriate Fire Extinguisher	  		  	X
				
		  	Additional hose connection in fit-up spaces to meet 150 foot distance requirements of Cambridge Fire Department.	  		  	X
				
	FIRE ALARM:	  	Base building expandable addressable fire alarm system that meets all code requirements.	  	X	  	
				
		  	Detection and annunciation devices (i.e. horns and strobes) in core areas and stair entries.	  	X	  	
				
		  	Detection, annunciation and all wiring in tenant areas and as required to tie into base building system.	  		  	X
				
	TELECOMMUNICATIONS	  	Main Distribution Frame (MDF) telephone room, core riser closets on each floor with sleeves through slab.	  	X	  	
				
		  	(4) 4” Conduits from City Service Ductbank into main tel/data closet in basement	  	X	  	
				
		  	Primary POS and distribution into tenant space	  		  	X
				
		  	Telephone and data wiring, conduits and outlets for Tenant areas from core closets.	  		  	X
				
		  	Audio-visual connections and systems for Tenant areas.	  		  	X
				
		  	Any special equipment needed to provide specific requirements for tenants telephone equipment.	  		  	X


  
 F-17 









							
	SECURITY:	  	(Base) Building security network system for monitoring and access control.	  	X	  	
				
		  	Card access at Building main entries, service doors, and traveling cable for security in elevators.	  	X	  	
				
		  	Card access in elevator cabs if required	  		  	X
				
		  	Electric door hardware and wiring on interior emergency egress doors in Stair #1 only.	  	X	  	
				
		  	Electric door hardware and wiring on interior emergency egress does in Stair #2	  		  	X
				
		  	Card access and/or alarm systems into or within Tenant’s premises. Emergency egress doors must be tied into Base Building Fire Alarm system.	  		  	X
				
		  	CCTV DVR surveillance in basement and at ground floor entries	  	X	  	
				
	SIGNAGE:	  	Building and site exterior address, directional, and any common identity signage to owner standards.	  	X	  	
				
		  	Building common area interior signage.	  	X	  	
				
		  	Signage within tenant’s space.	  		  	X
				
		  	Exterior Signage subject to Landlord Approval	  		  	X


  
 F-18 








 EXHIBIT G TO LEASE 

TENANT’S CONCEPT PLAN 

  
 G-1 








 



 

  








 EXHIBIT H TO LEASE 

TENANT DESIGN AND CONSTRUCTION GUIDELINES 

  
 H-1 








 



 

  
 H-2 









 



 
  
  

 

 Table of Contents 
  

					
	 Section I: Rules & Procedures for Tenant Contractors
	  	 	H-4	  
		
	 Section II: Insurance Requirements for Tenant Contractors
	  	 	H-12	  
		
	 Section III: Close-Out Requirements for Tenant Contractors
	  	 	H-16	  
		
	 Section IV: Tenant Improvement Standards
	  	 	H-18	  
		
	 Section V: LEED Guidelines
	  	 	H-22	  
		
	 Part A: Introduction and General Information
	  	 	H-23	  
		
	 Part B: LEED-CS and LEED-CI Certification
	  	 	H-25	  
		
	 1. Sustainable Sites (SS)
	  	 	H-25	  
	 2. Water Efficiency (WE)
	  	 	H-33	  
	 3. Energy and Atmosphere (EA)
	  	 	H-35	  
	 4. Materials and Resources (MR)
	  	 	H-38	  
	 5. Indoor Environmental Quality (IEQ)
	  	 	H-42	  
	 6. Innovation in Design (ID) 
	  	 	H-49	  
	 Appendix A: Reference Material
	  	 	H-50	  


  
 



 
 H-3 








 



 
  
 



 

  
 H-4 









 



 
  
  

 

 Section I: Rules & Procedures for Tenant Contractors 

Introduction 
 The following requirements apply only to
Tenant’s contractors and have been developed to ensure that modifications or improvements to the building and/or building systems and equipment are completed to building standards while maintaining a level of safety consistent with industry
standards. The review of tenant plans and/or specifications by Landlord and its insurers, consultants or other representatives, does not imply that any plans so reviewed comply with applicable laws, ordinances, codes, standards or regulations. Nor
does Landlord’s review or approvals imply that any work is to be performed at Landlord’s expense. 
 Landlord has the explicit right to remove
from the project any person who does not comply with these rules after one day’s notice. 
 Part A: General 

 

	1.	No work will be performed until the Landlord has received two (2) sets of signed and sealed drawings and specifications and has given written approval. 


 

	2.	All modifications to the building or to the building systems and equipment must comply with state, federal and local codes and ordinances. 


 

	3.	Prior to the work commencing, a building permit must be obtained and displayed and a certificate of insurance from the contractor must be furnished to the Landlord naming the as additional insureds all parties specified
in the Lease. 

  

	4.	At the completion of the work, the Leasehold Contractor shall furnish to the Landlord two (2) hard copies of redlined “as builts” as installed by the Leasehold Contractor and one (1) complete
CADD.DWG disk file showing the final architectural and engineering drawings. 

  

	5.	The contractor must notify the Landlord of all work scheduled and must provide the Landlord with a list of all personnel working in the building. 


 

	6.	The contractor must furnish the Landlord with a list of all subcontractors including emergency phone and/or pager numbers prior to commencing the work. 


 

	7.	The contractor must provide an on-site project superintendent at all times that construction work is underway. This supervisor must be knowledgeable of the project’s scope of work and have adequate on-site
reference materials including plans, specifications and MSDS information on all materials used in the performance of the work. 


  
 



 
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	8.	All workers must be dressed appropriately (appropriate dress will include hard hat, appropriate foot ware, etc.) to meet building safety standards that have been provided to Tenant in writing. Shirts must be worn at all
times. No shorts are permitted. 

  

	9.	All carts must be furnished with pneumatic tires and rubber bumpers. 

  

	10.	Smoking is not allowed in the building. 

  

	11.	The use of radios is prohibited. 

  

	12.	Prior to the start of work, all blinds must be raised and bagged, all windowsills and other base building components must be adequately protected and the protection must be maintained. Workers must not stand on
windowsills or other building components. 

  

	13.	Any work that requires access to another tenant’s space must first be coordinated through the Landlord. 

  

	14.	Dumping of construction debris into building drains, mop sinks, trash dumpsters, etc. is strictly prohibited. If this does occur, the contractor shall be charged 200% of the cost of clearing any drain, including
administrative time, where evidence of this is found. 

  

	15.	Base building restrooms within the construction area will be available for use by the contractor unless landlord dedicates an alternate location. Contractor shall be responsible for any damage to the restrooms and for
cleaning and stocking during construction. All other base building restrooms shall be locked and are not to be used by construction personnel. 

  

	16.	Use of the building stairwells for moving construction materials and construction personnel shall be limited to the stairwell designated by Landlord. No material may be brought through the Building lobby. Any damage
done to the stairwell (rails, doors and frames, sheetrock, ceilings etc.) shall be repaired by the Tenant contractor at its sole expense to the satisfaction to the Landlord. 


 

	17.	The contractor shall repair all construction disturbed by the new tenant work or damaged by the contractor’s or subcontractor’s personnel. 


 

	18.	After initial occupancy of the building, no work will be performed from 8:00 am to 8:00 pm Monday through Friday and 9:00 am to 4:00 pm Saturday that will disturb or inconvenience any existing tenants in the building
(e.g. core drilling, shooting track, noxious odors, etc.). The Landlord must preapprove any work that entails noise, vibration or noxious odors. 

  

	19.	All structural revisions, including but not limited to penetrations of slabs, are to be reviewed by Landlord’s engineer. 

  

	20.	Any roof related work must be performed by the roofing contractor designated by the Landlord. 


  
 



 
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	21.	The contractor shall immediately report all accidents to the Landlord in writing after first notifying the Landlord by telephone. 

  

	22.	Landlord shall provide the name of the manufacturer of lockset and key cores for compatibility with building master keying system. 


Part B: Life Safety 
  

	1.	Contractor shall furnish Landlord one set of sprinkler shop drawings and hydraulic calculations for approval by the Landlord’s insurance company once they are completed by subcontractor and ready for submittal to
the Fire Marshall. Once approved by the Fire Marshall, the contractor shall furnish Landlord one set of the approved sprinkler shop drawings. 

  

	2.	Contractor will not disconnect, tamper with, delete, obstruct, relocate, or expand any life safety equipment, except as indicated on drawings approved by the Landlord. Contractor shall not interfere with or delay any
other inspections scheduled prior to Contractors inspections or testing. 

  

	3.	The contractor must take necessary precautions to prevent accidental fire alarms. Any fees or costs charged to the Landlord by the local fire department that arise from accidental fire alarms caused by the contractor
will be paid by the contractor. The Landlord strongly suggests that, during any work that increases the likelihood of an accidental fire alarm such as demolition or sprinkler work, a person approved by the Landlord be designated to “watch”
the fire alarm panel. 

  

	4.	Any unit or device temporarily incapacitated will be red-tagged “Out of Service” and the Landlord will be alerted prior to the temporary outage. 


 

	5.	The base building fire alarm system shall monitor all tenant installed special fire extinguisher/alarm detection systems. The connections to the base building fire alarm system will be at the tenant’s expense. To
the extent the Premises are occupied, or same is otherwise required under Legal Requirements, fire “watch” shall also be provided by tenant contractor during any period fire alarm system is placed out of service for work or connection to
base building. 

  

	6.	All Tenant installed fire alarm initiation and notification devices that connect with the base building fire alarm system shall match the base building system and be approved by the Landlord. 


 

	7.	All connections to the building’s existing fire alarm system are to be made only by the subcontractor specified by the Landlord. 


 

	8.	All fire alarm testing will be scheduled at least 72 hours in advance with the Landlord and other contractors and must occur after normal business hours if the building is occupied. 


  
 



 
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	9.	Combustible and hazardous materials are not allowed to be stored in the building without prior written approval of the Landlord. Material safety data sheets on all materials to be stored in the building must be kept on
site and a copy submitted to the Landlord. 

  

	10.	Dust protection of smoke detectors must be installed and removed each day (if operational). Dust protection is required during construction to avoid false fire alarms and damaging of detector system. Filter media must
be installed over all return air paths to any equipment rooms prior to demolition. The media must be maintained during construction and removed at substantial completion. 


 

	11.	The building is to be fully protected by automatic sprinkler systems in accordance with Landlord’s standards and specifications. 


 

	12.	All sprinkler systems and equipment are to be designed and installed in accordance with the current standards of the National Fire Protection Association. 


 

	13.	All equipment, devices and materials used in the installation must be listed by UL and FM Approved. 

  

	14.	Connections to the base building sprinkler system/standpipe riser shall be provided with a control valve and water flow alarm device. Sprinkler system control valves shall be UL Listed and FM Approved, clockwise
closing, indicating valves with supervisory switches. 

  

	15.	All corrective work to the fire alarm system due to the contractor’s work shall be charged to the contractor. 

  

	16.	All fire alarm wiring in public areas (outside of Tenant demising walls) shall be in rigid conduit. 

 Part
C: Parking – Loading Dock 
  

	1.	Contractors, subcontractors and their personnel will not use the loading dock area for parking without first obtaining permission from the Landlord 24 hours in advance to assure dock availability. Unauthorized vehicles
will be ticketed and towed. 

  

	2.	Use of the loading dock for deliveries/trash removal must be scheduled through the Landlord. 

  

	3.	Material that does not fit into the service elevator must be delivered through a window opening. The contractor will be required to properly remove and replace the glass and to adequately protect the window framing with
prior approval from the Landlord. 

  

	4.	Any instance that requires the removal and replacement of exterior glass, must be approved by Landlord and performed by Landlord approved contractor. 


  
 



 
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 Part D: Utilities 
  

	1.	Utilities (i.e. electric, gas, water, telephone/cable) must not be cut off or interrupted without 48 hour notice and written permission of the Landlord. 


Part E: Security 
  

	1.	The contractor will be responsible for controlling any keys or access cards furnished by the Landlord and will return them to the Landlord. 


 

	2.	The contractor will be responsible for locking any secure area made available to the contractor whenever that area is unattended. 

  

	3.	Contractors may be required to wear identification badges, in which case the badges will be issued by the Landlord to the contractor. 


Part F: Elevators 
  

	1.	No passenger elevators will be used to move construction material or construction personnel. 

  

	2.	The passenger/service elevator can be used to move construction personnel at any time during the day, provided the elevator doors are not held open. The service elevator can not be used to move construction materials
into the building during building operating hours between the hours of 8:00 am and 8:00 p.m. unless approved in writing by Landlord. All other usage must be scheduled with the Landlord with at least 48 hours notice. 


 

	3.	Any costs to repair damage to the elevators including dust or dirt in machine rooms or shaft or costs for service calls resulting from the contractor’s operations will be charged to the contractor.


  

	4.	Any work on the elevators, call buttons and signal lanterns must be approved by Landlord and coordinated with building management. 


Part G: Cleaning 
  

	1.	The contractor will remove all trash and debris daily or as often as necessary to maintain cleanliness in the building. The building trash compactors or containers are not to be used for construction debris.


  

	2.	Walk-off mats or other protection must be provided at door entrances where work is being performed. 


  
 



 
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	3.	Carpeting shall be protected by plastic runners or hardboard as necessary to maintain cleanliness and to protect carpets from damage. 


 

	4.	Tile, terrazzo and wood floors shall be protected from damage as necessary. 

  

	5.	Contractor will furnish a vacuum(s) with a supply of clean bags and an operator to facilitate ongoing clean-up. 

  

	6.	Trash removal will be scheduled and coordinated with the Landlord and undertaken only through the service elevator. 

  

	7.	Contractors must remove all food cartons and related debris from the work area on a daily basis. 

  

	8.	Driveway and street cleaning by Contractor will be required when Contractor’s work has created mud or debris. 


Part H: Mechanical and Electrical Work 
  

	1.	Before any new electrical or mechanical equipment is installed in the building, the contractor must submit a copy of the manufacturer’s data sheets along with complete shop drawings and submittals to the Landlord
for approval. 

  

	2.	Any installation or modification to building HVAC or electrical systems must be first submitted to the Landlord for review. This includes base building systems as well as supplemental units and/or exhaust systems.


  

	3.	The mechanical and electrical plans must be prepared by a licensed engineer and engineer and must show size and location of all supply and return grilles. We may require that the Landlord’s MEP engineer review the
MEP drawings. In that event the tenant will pay for the cost of this review. We will notify the tenant prior to engaging the Landlord’s engineer. 

  

	4.	Contractors modifying ductwork, air grilles, VAV boxes, etc., must balance the air and water systems as necessary. All air balancing is to be done in the presence of the Landlord. Two copies of all balance reports shall
be submitted to Landlord for review and approval. 

  

	5.	Any domestic or condenser water connections made to the building’s piping system, must include a high quality isolation valve, (brass bodied gate or ball-type) and adequate system drain valves. If the system piping
is of a different material a dielectric union must be installed. All valves and equipment must be easily accessible; access doors are required in drywall or other fixed construction. 


 

	6.	Exhaust fans from cooking areas may not discharge into a return ceiling plenum. Such fans will be ducted to the outside via exhaust shafts or other routes as approved by the Landlord. 


  
 



 
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	7.	Where independent tenant-owned air conditioning units are installed, an electric submeter with a output that is compatible with the base building management system must be used or a flat rate electricity charge will be
paid by the Tenant based on anticipated consumption. 

  

	8.	The installation of tenant equipment (except emergency lighting per code) on the base building emergency power supply systems is not permitted. Tenant may seek Landlord review and approval for special circumstances.


  

	9.	Any existing mechanical or electrical systems and their controls that are to remain shall be properly commissioned. That is, at the beginning of the job the systems will be turned over to the contractor in working
condition by the Landlord. Before beginning any work, the contractor should inspect the mechanical or electrical systems and their controls to ensure their working condition. The contractor should advise the Landlord of any noted deficiencies. At
the end of the job, the contractor will be responsible for the proper operation of the mechanical and electrical systems. If the contractor fails to note any deficiencies at the outset of the job, the contractor will, nevertheless, be required to
correct the problems before the Landlord accepts the system. 

  

	10.	All circuit breaker panels must be clearly and accurately identified with typed labels. 

  

	11.	Tenant shall properly protect any of its mechanical equipment with prefilters, dust covers etc. prior to start of work, and shall not disturb any similar prefilters and covers covering base building mechanical
equipment. Protection shall be removed and equipment wiped down at completion. 

  

	12.	Energy management and building control work is to be performed by Landlord’s designated subcontractor. 

  

	13.	Tenant installed equipment that supplements existing base building equipment such as VAV boxes, fire alarm devices, control work etc., shall be identical to the existing base building equipment to facilitate warranty
and maintenance operations. 

  

	14.	All concealed equipment shall be located with necessary accessibility for maintenance and repair. 

  

	15.	Contractor shall contract Landlord 48 hours in advance for Landlord wall and ceiling close-in inspectors. 

  

	16.	No flexible conduit installed in the electrical closets. All runs inside the closet must be electrical metallic tubing (EMT). 


  
 



 
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 Section II: Insurance Requirements for Tenant Contractors 

Introduction 
 Tenant’s Contractors shall procure and
maintain for the duration of the contract insurance against claims for injuries to persons or damages to property which may arise from or in connection with the performance of the work hereunder by the contractor, his agents, representatives,
employees, or subcontractors. The cost of such insurance shall be included in the contractor’s bid, unless otherwise specified. 
 Part A: Minimum
Scope of Insurance 
 Coverage shall be at least as broad as: 
  

	1.	Insurance Services Office “occurrence” form CG 00 01 (ed. 10/93) covering commercial general liability or its equivalent. 

  


	2.	Insurance Services Office form CA 00 01 (ed. 6/92) covering automobile liability, coverage must apply to all owned, non-owned and hired vehicles. 


 

	3.	Workers compensation insurance as required by labor code of the jurisdiction in which the Building is located, and employers liability insurance. 


Part B: Minimum Limits of Insurance 
 Contractor shall
maintain limits no less than: 
  

	1.	Commercial general liability: $1,000,000 combined single limit per occurrence for death, bodily injury and property damage. Minimum $2,000,000 aggregate. (The general aggregate limit shall apply separately to this
project/location or the general aggregate shall be twice the required limit.). 

  

	2.	Automobile liability: $1,000,000 per person/$2,000,000 per accident for death, bodily injury and property damage. 

  

	3.	Workers compensation and employers liability: Workers compensation limits as required by the labor code of the jurisdiction in which the Building is located and employers liability limits of $1,000,000 per accident.


  

	4.	Umbrella Liability: $5,000,000 per occurrence and $5,000,000 aggregate (The aggregate limit shall apply separately to this project/location). 


Part C: Coverages 
  

	1.	General Liability and Automobile Liability Coverage 

 (a) The managing agent of the Building,
the holder of any mortgage, and their respective officers and employees are to be covered as additional insureds as 

  
 



 
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respects: liability arising out of activities performed by or on behalf of the contractor; products and completed operations of the contractor; premises owned, leased, or used by the contractor;
or automobiles owned, leased, hired, or borrowed by the contractor. 
 The coverage shall contain no special limitations on the scope of
protection afforded. 
 (b) The contractor’s insurance coverage shall be primary insurance as respects the Landlord, its officers,
officials, and employees. Any other insurance or self-insurance maintained by the Landlord, its officers, officials, and employees shall be excess of and not contribute with the contractor’s insurance. 

(c) Any failure to comply with reporting provisions of the policies shall not affect coverage provided to the agency, its officers, officials,
and employees. 
 (d) The contractor’s insurance shall apply separately to each insured against whom claim is made or suit is brought
except with respect to the limits of the insurer’s liability. 
 The insurer shall agree to waive all rights of subrogation against the
Landlord, its officers, officials, and employees for losses arising from work performed by the contractor for the Landlord. 
 Part D: All Coverages

 Each insurance policy required by this clause shall be endorsed to state that coverage shall not be suspended, voided, canceled by either party,
reduced in coverage or in limits except after 30 days’ prior written notice by certified mail, return receipt requested, has been given to the city. 

Part E: Acceptability of Insurers 
 Insurance is to be
placed with insurers licensed to do business in the jurisdiction in which the Building is located, that have been approved in advance by the Landlord, with a Best’s rating of no less than A:XI unless specific approval has been granted by the
Landlord. 
 Part F: Verification of Coverage 

Contractor shall furnish the Landlord with certificates of insurance evidencing the coverages required by this Article. The certificates for each insurance
policy are to be signed by a person authorized by that insurer to bind coverage on its behalf. The certificates are to be on ACORD Form 27 and/or ACORD Form 25-S, or other forms 

  
 



 
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that are similarly binding on insurers, which forms are to be received and approved by the Landlord before work commences. In addition, the Landlord shall require an endorsement naming the
Landlord, the managing agent of the Building, the holder of any mortgage and their respective officers and employees as additional insureds or loss-payees (whichever is applicable). The Landlord reserves the right to require Tenant to deliver
complete, certified copies of all required insurance policies, at any time. 
 Part G: Subcontractors 

Contractors shall include all subcontractors as insureds under their policies or shall furnish separate certificates for each subcontractor in the form
described in clause E above. All coverage for subcontractors shall be subject to all of the requirements stated herein. Commercial general liability coverage shall include independent contractors coverage, and the contractor shall be responsible for
assuring that all subcontractors are properly insured. 

  
 



 
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 Section III: Close-Out Requirements for Tenant Contractors 

The following are required from the general contractor prior to final payment being made: 

 

	1.	Two complete sets of all Operations and Maintenance Manuals bound in notebooks with an index, as specified in the project manuals. 

  

	2.	Two sets of blackline prints and one(1) CADD.DWG disk file including architectural, structural, plumbing, fire protection, elevator, mechanical, and electrical drawings. The as-built drawings must include modifications
made to the specifications, schedules and details and all changes initiated by requests for information and field orders. 

  

	3.	Copies of all building permits and certificates of occupancy, or occupancy permits. 

  

	4.	Final Releases of Liens from the general contractor and all subcontractors. 

  

	5.	One copy of all warranties bound in notebooks with a corresponding warranty log. 

  

	6.	One complete set of all approved submittals and shop drawings and a copy of the final submittal log. 

  

	7.	A complete list of all persons, including names, addresses, phone numbers and contact persons that will be providing warranty service during the warranty periods. 


 

	8.	One copy of NEBB certified air and water balancing reports. 

  

	9.	When the general contractor considers the work to be ready for final acceptance, written certification from the general contractor shall be submitted stating the following: 


 

	(a)	Work has been completed in accordance with the contract documents and Tenant Plans; 

  

	(b)	All punch list items and other deficiencies identified by the Certificate of Substantial Completion have been corrected; 

  

	(c)	Work has been inspected for compliance with the contract documents and Tenant Plans; 

  

	(d)	All mechanical and electrical equipment and systems have been tested in the presence of the Landlord’s representative and are operational. 


  
 



 
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 1.0 Ceiling 

1.1 All tile and grid shall be standard white, Class A fire rated, and contain recycled content. 

1.2 Perimeter Soffit detail shall be constructed as follows: 
  





 
 2.0 Wall Finishes 

Suggested Guidelines 
 2.1 All partitions shall
be finished with paint and standard base unless alternate is proposed. 
  

	(a)	Standard resilient wall base shall be 2  1⁄2” high. Cove base shall be used at all resilient or exposed flooring.
Straight base shall be used at all carpeted flooring. 


  
 



 
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 3.0 Doors/Hardware 

Suggested Guidelines 
 3.1 Suite Entry –
Glass Double Doors. Doors shall be 3’x8’,  1⁄2” frameless glass with polished edges and top and bottom rails. Hardware shall include vertical
pull bar with back to back mounting through door, a recessed and concealed header, and door closer. Standard hardware to be brushed stainless steel. 

3.2 Corridor Wood Doors. Doors shall be 3’x8’. Doors shall be flush, solid-core, paint-grade wood door with aluminum frame assembly. Doors shall
have mortised locksets and be equipped with a recessed, concealed header and door closer. Standard hardware to be brushed stainless steel. 
 3.3
Interior Wood Doors. Doors shall be 3’x8’. Doors shall be flush, solid-core, paint-grade wood door with aluminum frame assembly. Doors shall have butt hinges, cylindrical locksets and be equipped with a surface mounted door closer.
Standard hardware to be brushed stainless steel. 
 4.0 Lighting 

Suggested Guidelines 
 Use of indirect pendant
mounted ambient lighting system to reflect off high ceiling is preferred, with a design work surface illumination level of 25 – 30 foot-candles. 

Use of LED lighting is recommended for task lighting; 

Use light colored ceiling materials to reflect indirect lighting 

5.0 Partitions 
 Suggested Guideline 

Use low partitions (below 42”) to promote better lighting/day lighting and allow views to perimeter whenever possible 

  
 



 
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 In an attempt to maximize natural day lighting the use of light shelves and reflective ceiling materials
is encouraged to bounce light deep within the building. 
 6.0 Suite Entry Signage 

Subject to Article 24 of the Lease. 
 7.0 Window Blinds

 In accordance with landlord specified treatments. 

8.0 Flooring 
 Carpet and vinyl flooring adhesive to be
low VOC. 
 9.0 HVAC 
 9.1 See Building Shell Definition

 9.2 Subject to Landlord approval, Tenant may elect to install supplemental HVAC systems. All supplemental HVAC systems shall be sub metered. Supplemental
HVAC is not included in the turnkey cost – and would be paid for by Tenant. 
 10.0 Telephone/Data 

10.1 Pull string and trim ring at locations determined by Tenant. Entire cable plant will be contracted for directly between the Tenant and their vendor. 

10.2 All necessary communications equipment is the responsibility of the Tenant and shall be located completely with Tenant space. 

11.0 General Plumbing Requirements 

  
 



 
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 Part A: Introduction and General Information 

Why Green? 
 Buildings in the United States consume over
80% of the total electricity and more than 30% of total energy used annually. Buildings also utilize significant amounts of fresh water during both construction and occupancy. Material waste during construction accounts for up to 53% of landfill
waste, depending on location. A well designed, sustainable building works to reduce impact on the environment while garnering financial and health-related benefits for the Owner and Tenants. 

Currently, people spend over 90% of their time in buildings – much of that time at work. One benefit of a green building for occupants is the more
comfortable and controllable environment designed into sustainable buildings. The impact of such an attribute can be manifested in increased employee retention and productivity. 

United States Green Building Council and LEED 
 The United
States Green Building Council (USGBC) is a nonprofit organization committed to expanding sustainability in the built environment. Its mission is to transform the way buildings and communities are designed, built and operated, enabling an
environmentally and socially responsible, healthy, and prosperous environment that improves the quality of life. LEED (Leadership in Energy and Environmental Design) is a voluntary, consensus-based national rating system for developing
high-performance, sustainable buildings. 
 Developed by the USGBC, LEED addresses all building types and emphasizes state- of-the-art strategies for
sustainable site development, water savings, energy efficiency, materials and resource selection, and indoor environmental quality. LEED is a voluntary rating system for green building design and construction that provides immediate and measurable
results for building owners and occupants. 
 Opportunities for Tenants 

Tenants at 150 Second have a remarkable opportunity to help lead the shift to sustainability in buildings, and in the process define a new kind of workplace.
By locating in a LEED Gold building, tenants will benefit from a high performance building with excellent indoor air quality and ample daylight and views. These and other elements combine to create a healthier workplace and improve the indoor
environment for all 

  
 



 
 H-23 









 



 
  
  

 

 
employees. In addition, 150 Second has set a higher standard with high-performance technologies that use less energy, consume less water, and leave a smaller footprint on the city’s
resources. Some of the building’s innovative features will be noticed at once: low flow plumbing fixtures and the zero irrigation rain garden. Others, such as energy-saving base building mechanical systems will exist behind the scenes, quietly
but significantly setting the building apart from its neighbors. 
 The LEED Guidelines that follow summarize the measures that Skanska has taken to achieve
LEED Gold certification for 150 Second. These guidelines are intended to help tenants understand and take full advantage of the high-performance features of the building, and to provide guidance in ways that tenants can reinforce these features 

in their own workplaces. 
 Skanska set a goal of achieving LEED
Gold for the base building at 150 Second using LEED for Core and Shell (LEED-CS) version 2009. We can only design and build the building, however. It is up to our tenants to fit it out and operate it in an environmentally friendly way. To do this,
we recommend you use the LEED for Commercial Interiors (LEED-CI) rating system. The intent of LEED-CI is to assist in the creation of high-performance, healthy, durable, affordable and environmentally sound commercial interiors. Together LEED-CS and
LEED-CI address the commercial office real estate market for both developers and tenants enabling significant benefits through improved indoor air quality, maximized day lighting and lower energy costs. A copy of the LEED 

-CI 2009 Scorecard and link to the Rating System are included in Appendix A for reference by tenants who wish to explore more information on timing and
detailed strategies. 

  
 



 
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 Project Data 
  

			
	Floor Area:	  	123,210 rentable square feet (total)
		
	Occupancy Group:	  	Group S-2, Low Hazard Storage (Parking Garage)
		
		  	Group B, (30%) and Lab areas (70%)
		
	Construction Type:	  	IB
		
	Building Address:	  	 150 Second Street
 Cambridge, MA
02141


 Part B: LEED-CD and LEED-CI Certification 

Base Building Certification at 150 Second 
 The LEED
Guidelines that follow summarize the measures Skanska has undertaken to achieve LEED certification under the LEED for Core and Shell (LEED-CS) rating system. It is intended to help tenants understand and take full advantage of the high-performance
features of the building, and to provide guidance to assist tenants in reinforcing these features in their own workplaces. It will also provide tenants with guidance and information on achievement of LEED for Commercial Interiors (LEED-CI). 

Sustainable Sites (SS) 
 The LEED requirements for the
Sustainable Sites category are predominantly base-building responsibilities. A tenant applying for LEED for Commercial Interiors (LEED-CI) certification automatically gains five credits simply by choosing to be a tenant in the LEED-CS building at
150 Second. 
 SSp1: Erosion and Sedimentation Control 

Intent Reduce pollution from construction activities by controlling soil erosion, water-way sedimentation and airborne dust generation. 

LEED-CS This prerequisite is normally required as a routine part of the site design and city entitlement process. 150 Second complied with the
requirements of this prerequisite 

  
 



 
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by developing and adhering to a Stormwater Pollution Prevention Plan as required by the United States Environmental Protection Agency. Tenants benefit by knowing that the construction process of
the LEED-CS building had minimal negative impact on the local environment in terms of loss of soil, sedimentation of local storm-sewer systems, and localized air pollution. 

LEED-CI No related LEED-CI credit. 
 SSc1: Site
Selection 
 Intent Avoid development of inappropriate sites and reduce the environmental impact from the location of a building on the site. 

LEED-CS 150 Second meets all of the stated criteria for this credit. By developing in a dense, urban neighborhood, urban sprawl is reduced, as is the
pressure to develop in environmentally sensitive areas. The LEED-CS building did not develop on prime farmland, within a flood plain, near wetland areas, on land protected for endangered species, or on former public parkland. Location by the tenant
in 150 Second helps to preserve these valuable environmental resources. 
 LEED-CI No related LEED-CI credit. Tenants attempting LEED-CI at 150
Second will earn five points for locating in a LEED-CS building. This is associated with LEED-CI SSc1: Site Selection. 
 SSc2: Development Density and
Community Connectivity 
 Intent Channel development to urban areas with existing infrastructure to protect greenfields, and persevere habitat and
natural resources. 
 LEED-CS 150 Second is located on a previously developed site, within one-half mile of a dense residential zone and within close
pedestrian access to more than ten basic community services. Pedestrians also have easy access to all community services. Tenants benefit from the close proximity of numerous services such as restaurants, shopping, and groceries. The close proximity
of neighborhood and community services help to reduce pollution caused by the use of motor vehicles. 150 Second also meets the development density path of this credit. 

  
 



 
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 LEED-CI Tenants attempting LEED-CI at 150 Second will earn six LEED-CI points through SSc2:
Development Density and Community Connectivity. 
  
 



 
 SSc3: Brownfield Redevelopment 

Intent Remediate and redevelop sites deemed as contaminated in order to restore the health of the site and avoid development of greenfield sites. 

LEED-CS 150 Second is located on a site that was previously contaminated. The site has been remediated. Remediation and redevelopment of brownfield
sites is a huge undertaking by a developer, and Skanska is proud to have redeveloped this site and make it suitable for living and working conditions. 

LEED-CI Brownfield redevelopment is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 

SSc4.1: Alternative Transportation-Public Transportation Access (LEED-CI SSc3.1) 

Intent Locate project near public transportation to reduce the number of vehicles on the road and to reduce land redevelopment for parking. 

  
 



 
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 LEED-CS 150 Second is located within one-quarter mile walking distance of the Lechmere T stop and
multiple bus lines. Locating in close proximity to rail and multiple bus lines is beneficial to tenants and their visitors because of the convenience of public transit access. This also reduces the need to drive cars to the site, thereby reducing
environmental impacts associated with pollution and development. 
 LEED-CI Tenants attempting LEED-CI at 150 Second will earn six points meeting the
credit requirements of SSc3.1: Alternative Transportation-Public Transportation Access in the LEED-CI rating system. 
 SSc4.2: Alternative
Transportation – Bicycle Storage and Changing Rooms 
 (LEED-CI SSc3.2) 

Intent Include bike racks and showering facilities to encourage building occupants to bike to the site, in an effort to reduce the number of vehicles on
the road and to reduce land development for parking. 
 LEED-CS 150 Second provided 22 long-term and 8 exterior bike storage spaces for an estimated
>8% of the assumed building users and provided 2 shower and changing rooms. This exceeds the requirement of racks for 3% of all building users and provided showering for an estimated 0.5% of full-time equivalent (FTE) occupants 

LEED-CI Tenants attempting LEED-CI at 150 Second may be able to earn two points for LEED-CI SSc3.2: Alternative Transportation-Bicycle Storage and
Changing Rooms. However, LEED-CI projects must provide bike racks for 5% of tenant occupants and showers for 0.5% of FTE. Tenants should verify that the bike racks and showers provided in the base building meet the required numbers for the tenant
space. The base building provides sufficient bike storage to satisfy the requirements for 600 total peak users and changing facilities for 400 total FTE’s. 

  
 



 
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 SSc4.3 Alternative Transportation – Low-Emitting and Fuel-Efficient Vehicles 

Intent Encourage the use of low-emitting and fuel-efficient (LE/FE) vehicles by providing preferred parking spaces for LE/FE vehicles. 

LEED-CS 150 Second will offer 5 preferred spaces for vehicles that meet the LEED definition of Low-Emitting and Fuel Efficient Vehicles. 

LEED-CI There is no related LEED-CI credit. 
 SSc4.4:
Alternative Transportation – Parking Capacity (LEED-CI SSc3.3) 
 Intent Minimize parking spaces and provide preference to carpool and
vanpool vehicles, in an effort to reduce the number of vehicles on the road and to reduce land development for parking. 
 LEED-CS 150 Second
minimized the total parking capacity to not exceed local zoning requirements but was not required to provide preferred parking for carpools or vanpools to meet the credit requirements. Parking capacity was minimized in an effort to reduce land
development. 
 LEED-CI Tenants attempting LEED-CI at 150 Second may be able to earn two points for LEED-CI SSc3.3: Alternative Transportation –
Parking Availability, which requires minimized parking for tenants and preferred parking for carpools and vanpools. Tenants in a LEED-CS building do not automatically meet this credit and will have to determine the maximum number of parking spaces
available to them and provide the preferred parking spaces. See the LEED-CI Rating System for exact requirements. 
 SSc5.1: Site Development –
Protect or Restore Habitat 
 Intent Conserve native habitat in an effort to promote biodiversity. 

LEED-CS 150 Second did not pursue this credit. 

LEED-CI There is no related LEED-CI credit. 
 SSc5.2:
Site Development – Maximize Open Space 
 Intent Provide a high ratio of open space to development footprint to promote biodiversity. 

  
 



 
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 LEED-CS Although 150 Second did not pursue this LEED credit, the Project increased the amount of
vegetated open space which provides tenants with added amenities and park space. 
 LEED-CI There is no related LEED-CI credit. 

SSc6.1: Stormwater Design – Quality Control 

Intent Limit disruption of natural hydrology by reducing impervious cover, increasing onsite infiltration, and managing stormwater runoff quantities.

 LEED-CS 150 Second implemented a stormwater management plan that reduced the stormwater runoff by 25% compared to pre-development volumes. Tenants
and the local community benefit from the stormwater management plan due to less stormwater runoff and less contamination entering local waterways. Post development conditions show 44.92% reduction in 2 year, 24-hour design storm. 

LEED-CI Stormwater management is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 

SSc6.2: Stormwater Design – Quality Control 

Intent Limit disruption of natural hydrology by reducing impervious cover, increasing on-site infiltration, and managing the quality of stormwater
runoff. 
 LEED-CS 150 Second has provided a new stormwater technology that captures and treats stormwater runoff from 90% of the annual rainfall and
removes at least 95.58% of total suspended solids. Tenants and the local community benefit from the stormwater management plan due to less stormwater runoff and less contamination entering local waterways. 

LEED-CI Stormwater management is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 

SSc7.1 Heat Island Effect – Nonroof 
 Intent
Reduce heat island effect (thermal gradient differences between developed and undeveloped areas) to minimize impact on microclimate, and human and wildlife habitat. 

  
 



 
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 LEED-CS 150 Second has placed 84% of the total parking capacity under a white roof in an effort to
reduce the heat island effect. By placing the majority of parking spaces under one cover in a stacked parking garage, 150 Second is able to reduce the amount of asphalt required for the same number of parking spaces and therefore minimize local heat
island effects. 
 LEED-CI The heat island effect is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a
LEED-CS building. 
 SSc7.2: Heat Island Effect – Roof 

Intent Reduce heat island effect (thermal gradient differences between developed and undeveloped areas) to minimize impact on microclimate, and human
and wildlife habitat. 
 LEED-CS 150 Second installed a light colored roof which reduces the heat island effect. Tenants will benefit from more
efficient operations of the HVAC system in the building, which is passed on to the tenants in reduced energy costs. 
 LEED-CI The heat island effect
is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 
 SSc8: Light Pollution Reduction

 Intent Reduce the impacts of lighting on nocturnal environments, reduce glare, and minimize light trespass from interior windows. 

LEED-CS 150 Second did not pursue this credit. 

LEED-CI Light pollution reduction is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building.

 SSc9: Tenant Design and Construction Guidelines 

Intent Provide tenants with a descriptive tool that both educates and helps implement sustainable design and construction features in their tenant
improvement build-out. 

  
 



 
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 LEED-CS Tenant Design and Construction Guidelines benefit the LEED-CS certified project for two
important reasons. First, the Guidelines help tenants design and build sustainable interiors and adopt green building practices; second, the Guidelines help in coordinating LEED-CI and LEED-CS certifications. These Guidelines are a tool to enable
tenants of 150 Second to design and implement sustainable, green building interiors that will benefit the overall health and quality of life for building occupants. 

LEED-CI No related LEED-CI credit. 
 Water Efficiency
(WE) 
 WEp1: Water Use Reduction – 20% Reduction and WEc3: Water Use Reduction 

Intent Maximize water efficiency within buildings to reduce the burden on municipal water supply and wastewater systems. 

LEED-CS 150 Second installed base building fixtures to achieve the prerequisite of 

20% water reduction but also earned additional points and achieved an overall water use reduction of 39% for showers, low-flush toilets and low-flush urinals.
In total, these measures will reduce water consumption of the building by approximately 
 250,000 gallons per year. 

LEED-CI Tenants attempting LEED-CI at 150 Second will also need to meet the 20% water use reduction prerequisite. This prerequisite addresses only
toilets, urinals, lavatory faucets, prerinse spray valves and showerheads. 150 Second has ultra low-flow metering lavatories, low-flow showers, low-flow toilets and low-flush urinals that tenants will be using and can take advantage of in compliance
with LEED-CI. The tenant’s participation in this credit guideline could further support reduction of water use. 
 150 Second encourages tenants to
employ water efficient fixtures in other areas of their space such as installing ultra flow faucets (0.5 gpm) in pantry/kitchenette laboratory and/or prerinse spray valves below the baseline. By employing similar strategies for the tenant space, the
tenant has the opportunity to achieve up to 11 points for WEc1: Water Use Reduction within the LEED-CI rating system. 
 Goals for Tenant Water Fixtures:

  

	•	 	Low Flow Water Closets (1.28 gpf) – Already in core toilet rooms. 


  
 



 
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	•	 	Pint Flush Urinals (0.125 gpf) – Already in core toilet rooms. 

  

	•	 	Ultra Low Flow Metering Lavatories (0.83 g/cycle) – Already in core toilet rooms. 

  

	•	 	Ultra Low Flow Kitchen and Janitorial Sinks (1.0 gpm) 

  

	•	 	Ultra Low Flow Shower Fixtures (1.5 gpm) – Already in core shower rooms. 

  

	•	 	Residential Dishwashers (Energy Star) 

  

	•	 	Commercial Dishwashers (1.0 gallons/rack) 

  

	•	 	Residential Clothes Washers [4.5 WF (gallons/ft3/cycle)] 

  

	•	 	Commercial Clothes Washer [7.5 WF (gallons/ft3/cycle)] 


WEc1: Water Efficient Landscaping 
 Intent Reduce
potable water consumption for irrigation through the use of high-efficient technologies and low-water consuming plantings. 
 LEED-CS 150 Second
installed limited turf grass and drought-resistant plants that require no permanent irrigation. These measures have resulted in a 100% potable water use reduction for irrigation. 

LEED-CI Water-efficient landscaping is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building.

 WEc2: Innovative Wastewater Technologies 

Intent Reduce wastewater generation and minimize the impact on municipal wastewater treatment plants. 

LEED-CS 150 Second installed an onsite rainwater storage system that treats water to tertiary standards. The treated rainwater is then reused for the
toilets and urinals. This rainwater storage system reduces water use for toilets and urinals by 85%. 
 LEED-CI Innovative wastewater technologies
are covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 

  
 



 
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 Energy and Atmosphere (EA) 

EAp1: Fundamental Commissioning and EAc3: Enhanced Commissioning 

(LEED-CI, EAc2: Enhanced Commissioning) 
 Intent

 Fundamental: To verify that the project’s energy-related systems are installed, calibrated and perform according to the owner’s
project requirements, basis of design and construction documents. Benefits of commissioning include reduced energy use, lower operating costs, reduced contractor callbacks, better building documentation, improved occupant productivity and
verification that the systems perform in accordance with the owner’s project requirements. 
 Enhanced: To begin the commissioning
process early in the design process and execute additional activities after systems performance verification is completed. 
 LEED-CS 150 Second
performed enhanced commissioning of all base building energy systems, including base building HVAC system and controls, domestic hot water, core and lobby lighting systems and controls and building management system. This process helped to assure
all energy-related systems are operating as intended. 
 LEED-CI Tenants attempting LEED-CI at 150 Second are required to perform fundamental
commissioning of their energy-related systems. Additionally, tenants can achieve five points if they elect to perform enhanced commissioning (EAc2). 

EAp2: Minimum Energy Performance 
 Intent To
establish the minimum level of energy efficiency for the proposed building and systems to reduce environmental and economic impacts associated with excessive energy use. 

LEED-CS 150 Second performed whole building energy simulation using ASHAE 90.1-2007 Appendix G and has met the requirements for energy performance. 150
Second energy simulation demonstrated an improvement of 43% over ASHRAE 90.1-2007. The building envelope was designed to improve energy efficiency and reduce the cost of energy for the entire building, these savings are passed on to the tenant. 

LEED-CI Minimum Energy Performance of the tenant space is a prerequisite in the LEED-CI rating system CAp2. Tenants attempting LEED-CI at 150 Second
are required to comply with the mandatory provisions and prescription requirements of ASHRAE 90.1-2007, as well as reduce connected lighting power density by 10% from ASHRAE 90.1-2007 and install Energy Star appliances for at least 50% of eligible
equipment. Tenants occupying space in 150 Second will benefit from the energy efficiencies of the base building systems but will not be automatically guaranteed credit compliance. 

  
 



 
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 EAp3: Fundamental Refrigerant Management 

Intent To reduce stratospheric ozone depletion. 

LEED-CS 150 Second installed new HVAC systems which contained no Chlorofluorocarbon (CFC)-based refrigerants which thereby reduce the buildings impact
on the ozone. 
 LEED-CI Tenants attempting LEED-CI at 150 Second are required to comply with this prerequisite through either the purchase of new
HVAC equipment which contains no CFC-based refrigerants or upgrading of existing equipment which contains CFC-based refrigerants. 
 EAc1: Optimize
Energy Performance 
 Intent To achieve increasing levels of energy performance beyond the prerequisite standard and to reduce environmental and
economic impacts associated with excessive energy use. 
 LEED-CS 150 Second performed whole building energy simulation using ASHAE 90.1-2007
Appendix G and has met the requirements for energy performance. 150 Second energy simulation demonstrated an improvement of 43% over ASHRAE 90.1-2007. 

LEED-CI Tenants attempting LEED-CI at 150 Second can earn points for further enhancing energy efficiency. These combined strategies will contribute
toward further reductions in environmental and economic impacts for the project. Points are achievable across different areas of energy related systems as follows: 

EAc1.1: Optimize Energy Performance – Lighting Power: Projects can achieve up to five points for further reductions in lighting
power density below ASHRAE 90.1-2007. 
 Recommendations for Tenant Lighting Systems: 

 

	 	•	 	Display lighting: metal halide, fluorescent, or LED lamps rather than halogen. 


  
 



 
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 EAc1.2: Optimize Energy Performance – Lighting Controls: Projects that install
lightning controls such as daylight and occupancy sensors can achieve up to three points in and contribute towards increased energy conservation. 

Recommendations for Tenant Lighting Controls: 
  

	 	•	 	Install daylight responsive controls in all regularly occupied spaces within 15 feet of windows and under skylights. 


EAc1.3: Optimize Energy Performance – HVAC: Through increased HVAC equipment efficiencies and appropriate zoning and controls,
which result in HVAC performance above ASHRAE 90.1-2007, projects are eligible for up to 10 points. 
 Recommendations for Tenant HVAC
Systems: 
  

	 	•	 	High SEER condensing units – minimum 14 SEER. 

  

	 	•	 	Air source heat pump heating. 

  

	 	•	 	Electronically Controlled Motors (ECM) in fan coils. 

  

	 	•	 	Demand ventilation controls with CO2 sensors. 

 EAc1.4: Optimize Energy Performance –
Equipment and Applications: Selecting energy-efficient equipment and appliances, as qualified by EPA’s Energy Star Program, can contribute up to 4 points. 

EAc2: On-Site Renewable Energy 
 Intent To
encourage and recognize increasing levels of on-site renewable energy self-supply to reduce environmental and economic impacts associated with fossil fuel energy use. 

LEED-CD 150 Second did not pursue this credit. 

LEED-CI On-site renewable energy is covered under LEED-CI SSc1: Site Selection, where tenants earn five points for locating in a LEED-CS building. 

EAc5: Measurement and Verification (LEED-CI, EAc3) 

Intent To provide for the ongoing accountability of building energy consumption over time. 

LEED-CS 150 Second did not pursue this credit. 

  
 



 
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 LEED-CI Tenants attempting LEED-CI at 150 Second can earn points by providing ongoing accountability
and optimization of their energy and water consumption over time. 150 Second has provided tenants a lease agreement in which energy costs are paid by the tenants and not included in the base rent, making the tenants eligible for three points in
LEED-CI (EAc3-Measurement & Verification). Furthermore, the base building central monitoring system allows tenants the ability to easily install submetering devices within their space. 

EAc6: Green Power (LEED-CI, EAc4) 
 Intent To
encourage the development and use of grid-source, renewable energy technologies on a net-zero pollution basis. 
 LEED-CS 150 Second did not pursue
this credit. 
 LEED-CI Tenants attempting LEED-CI at 150 Second can earn five points by engaging in a 2 year renewable energy contract through
LEED-CI EAc4. The contract amount must be for at least 50% of the energy consumed in the tenant space for at least 8 kilowatt hours per square foot of tenant space. 

Materials and Resources (MR) 
 MRp1: Storage and
Collection of Recyclables 
 Intent Facilitate the reduction of waste generated by building occupants that is hauled to and disposed of in
landfills. 
 LEED-CS 150 Second provides a centrally located, easily accessible area for recycling of paper, cardboard, glass, plastics and metals,
for the base building and tenant occupants. The recycling storage area is located at Room 119 near the loading dock. 
 LEED-CI Tenants attempting
LEED-CI at 150 Second are provided with an easily accessible dedicated area for tenants recycling (paper, corrugated cardboard, glass, plastics and metals). This is a prerequisite in the LEED-CI rating system (MRp1) and LEED-CI projects will
automatically earn this prerequisite. Tenants are strongly encouraged to create a dedicated recycling area on each floor to facilitate efficient sorting and recycling of waste materials. 

  
 



 
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 MRc1.1: Tenant Space – Long-term Commitment (LEED-CI Only) 

Intent To encourage choices that conserve resources, reduce waste and the environmental impacts of tenants related to materials, manufacturing and
transportation. 
 LEED-CS There is no related LEED-CS credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second are encouraged to pursue a ten-year lease. Doing so will help earn LEED-CI MRc1.1. 

MRc1.2: Building Reuse – Maintain Interior Nonstructural Elements 

Intent To reduce the environmental impact of new construction by salvaging old building stock. 

LEED-CS 150 Second did not pursue this credit. 

LEED-CI Tenants LEED-CI at 150 Second may earn a point for the interior salvage of the floors, walls and doors, as long as tenants preserve these
elements during fit-out. Projects can up to two points for MRc1.2: Building Reuse-Maintain Interior Nonstructural Components for maintain 40% or 60% of interior components. 

MRc2: Construction Waste Management 
 Intent Divert
Construction and demolition debris from disposal in landfills and incinerators. Redirect recyclable recovered resources back to the manufacturing process. Redirect reusable materials to appropriate sites. 

LEED-CS 150 Second implemented a Construction Waste Management Plan that resulted in diverting over 95% of the project’s construction and
demolition waste from being disposed in landfills. 
 LEED-CI Tenants attempting LEED-CI at 150 Second can develop and implement their own
construction waste management plan during the construction of the tenant space, and by recycling 50% or 75% of construction, demolition and packaging debris, tenants can qualify for up to two points for MRc2.1: Construction Waste Management. 

  
 



 
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 MRc3: Materials Reuse (LEED-CI, MR3.1) 

Intent To reduce the environmental impact of new construction by salvaging materials. 

LEED-CS 150 Second did not pursue this credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second can earn up to two LEED-CI points under MRc3.1: Materials Reuse by using salvaged old doors and
windows to make interior partitions, and an additional credit for MRc3.2: Materials Reuse – Furniture and Furnishing for reusing furniture. 

MRc3.2: Materials Reuse – Furniture and Furnishing (LEED-CI Only) 

Intent To reduce the environmental impact of new construction by salvaging materials. 

LEED-CS There is no related LEED-CS credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second can refurnish, reuse or salvage 30% of their total furniture cost to earn an additional LEED-CI point.

 MRc4: Recycled Content 
 Intent Increased
demand for building products that incorporate recycled content materials, thereby reducing impacts resulting from extraction and processing of virgin materials. 

LEED-CS 150 Second specified the use of a minimum of 20% of building materials (by cost) as recycled materials, containing post-consumer or
post-industrial recycled content. 
 LEED-CI Tenants attempting LEED-CI at 150 Second can specify 10% – 20% of materials to have recycled
content, out of the total amount of construction materials and furnishings, the tenant can achieve two LEED points through MRc4: Recycled Content. Consider specifying products such as structural steel, gypsum board and concrete to have high-recycled
content. 
 MRc5: Regional Materials 
 Intent
Increase demand for building materials and products that are extracted and manufactured within the region, thereby supporting the use of indigenous resources and reducing the environmental impacts resulting from transportation. 

  
 



 
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 LEED-CS 150 Second specified the use of a minimum of 10% of building materials (by cost) to be
regionally extracted and manufactured (within 500 miles of the site). 
 LEED-CI Tenants attempting LEED-CI at 150 Second can specify 20% of the
combined value of construction materials and furnishings to be manufactured regionally (within 500 miles of the site) to earn a LEED-CI point for MRc5: Regional Materials. If 10% of those materials are also extracted, harvested or recovered from
within 500 miles of the project, tents earn an additional point under MRc5, Option 2. 
 MRc6: Rapidly Renewable Materials (LEED-CI Only) 

Intent To reduce the environmental impact of finite raw materials that have long-cycles of growth. 

LEED-CS There is no related LEED-CS credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second are encouraged to specify a minimum of 5% of the total value of all building materials from rapidly
renewable sources to earn a LEED-CI point through MRc6: Rapidly Renewable Materials. Rapidly renewable materials are agricultural products, either fiber or animal, which take ten years or less to grow or raise and then harvested in an ongoing and
sustainable fashion. Bamboo, wool, carpets, cork, rubber, strawboard and wheatboard are all examples of rapidly renewable resources. 
 MRc6: Certified
Wood (LEED-CI, MRc7) 
 Intent Encourage environmentally responsible forest management. 

LEED-CS 150 Second specified a minimum of 50% of wood-based products to be harvested in accordance with the Forest Stewardship Council’s (FSC)
Principles and Criteria, for base building wood components. FSC certification means that the forest managers employed environmentally and socially responsible forest management practices. FSC wood has been specified for base building finishes such
as the lobby wall paneling and cabinetry. 
 LEED-CI Tenants attempting LEED-CI at 150 Second are encouraged to specify certified wood for new wood
products and materials for their space. A minimum of 50% of certified wood used in the project is required to achieve a LEED-CI point through 
 MRc7:
Certified Wood. 

  
 



 
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 Indoor Environmental Quality (IEQ) 

IEQp1: Minimum Indoor Air Quality Performance 

Intent To establish minimum indoor air quality (IAQ) performance to enhance indoor air quality in buildings, thus contributing to the comfort and
well-being of the occupants. 
 LEED-CS 150 Second has met the requirements of Section 4 through 7 of ASHRAE Standard 62.1-2007, Ventilation for
Acceptable Indoor Air Quality for the base building, and goes beyond the ventilation rates required by the prerequisite to provide 30% more ventilation than required by the ASHRAE standard. The base building HVAC system supports this design by
providing at least 20 cubic feet per minute of outside air per person, based on standard occupancy densities. The tenants from this by increased productivity. 

LEED-CI Tenants attempting LEED-CI at 150 Second are required to supply minimum levels of ventilation through compliance with ASHRAE 62.1-2007.
Depending on the location of the tenant spaces, tenants may need to provide adequate ventilation for their spaces to meet LEED-CI IEQp1: Minimum Indoor Air Quality Performance. Some spaces in the tenant building will automatically comply, others
will need to provide ventilation in their own spaces. Contact building management for details on your tenant space. 
 IEQp2: Environmental Tobacco Smoke
Control 
 Intent To minimize exposure of building occupants, indoor surfaces and ventilation air distribution systems to environmental tobacco
smoke (ETS). 
 LEED-CS 150 Second has prohibited smoking inside the building, and prohibited smoking on the property from within 25 feet of entries,
outdoor air intakes and operable windows. 
 LEED-CI Tenants attempting LEED-CI at 150 Second will automatically comply with this prerequisite,
through LEED-CI IEQp2: Environmental Tobacco Smoke Control, 

  
 



 
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due to the building’s no smoking policy. Tenants are prohibited from smoking within the building and have ben provided designated smoking areas which are at least 25 feet away from building
entries, outdoor air intakes and operable windows. Signage indicating that smoking is not allowed within 25 feet of the all entrances will be provided for the entire building. 

IEQc1: Outdoor Air Delivery Monitoring 
 Intent To
provide capacity for ventilation system monitoring to help promote occupant comfort and well-being. 
 LEED-CS 150 Second has installed a permanent
monitoring system to ensure that ventilation systems in all public spaces maintain design minimum requirements. This has been accomplished through the incorporation of CO2 monitoring devices and outdoor airflow measurement devices within the base
building. Furthermore, the installed system in the base building is capable of being expanded to provide CO2 monitoring within the tenant spaces. 

LEED-CI Tenants attempting LEED-CI at 150 Second can achieve one point for installing permanent ventilation monitoring systems within their tenant
space, through IEQc1: Outdoor Air Delivery Monitoring. 
 IEQc2: Increased Ventilation 

Intent To provide additional outdoor air ventilation to improve indoor air quality (IAQ) and promote occupant comfort, well-being and productivity. 

LEED-CS 150 Second has increased breathing zone outdoor air ventilation rates to all occupied spaces by at least 30% above the minimum rates required
by ASHRAE 62.1-2007 for the base building. Furthermore, the base building systems have provided tenants with the ability to achieve LEED-CI, IEQc2: Increased Ventilation within their space by providing increased ventilation for each zone. 

LEED-CI Tenants attempting LEED-CI at 150 Second can achieve one point, through LEED-CI IEQc2: Increased Ventilation, by providing additional air
ventilation through appropriate mechanical or natural ventilation design strategies. The base building has provided the ability to easily facilitate increased ventilation within the tenant space. 

  
 



 
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 IEQc3: Construction Indoor Air Quality Management Plan – During Construction 

(LEED-CI, IEQc3.1) 
 Intent To reduce indoor air
quality (IAQ) problems resulting from construction or renovation and promote the comfort and well-being of construction workers and building occupants. 

LEED-CS 150 Second has developed and implemented an IAQ management plan for the construction and pre-occupancy phases for the base building. As a
result, the base building has provided a healthy indoor environment for tenants as they commence occupancy in their space. Measures taken as part of the IAQ plan included enclosed space ventilation, protection of absorption materials from moisture
damage, replacement of filters prior to occupancy, among other requirements from the Sheet Metal and Air Conditioning National Contractors Association (SMACNA) guidelines. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point, through LEED-CI IEQc3.1: Construction IAQ Management Plan – During
Construction, for developing and implementing their own IAQ management plan for the construction and preoccupancy phases of the tenant space. 
 IEQc3.2:
Construction Indoor Air Quality Management Plan – Before Occupancy  
 Intent To reduce indoor air quality (IAQ) problems resulting
from construction or renovation to promote the comfort and well-being of construction workers and building occupants. 
 LEED-CS There is no related
LEED-CD credit. 
 LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by performing a building flush-out or air testing the
tenant space to ensure a healthy indoor environment. 
 IEQc4.1: Low-Emitting Materials-Adhesives & Sealants 

Intent To reduce the quantity of indoor air contaminants that are odorous, irritating and/or harmful to the comfort and well-being of installers and
occupants. 
 LEED-CS 150 Second has complied with the applicable volatile organic compound (VOC) requirements for all adhesives and sealants
installed within the weather barrier for the base building. As a result, the base building has provided a healthy indoor environment for tenants as they commence occupancy in their space. 

  
 



 
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 LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by ensuring that all adhesives
and sealants installed within the tenant space comply with the applicable VOC limits. 
 IEQc4.2: Low-Emitting Materials – Paints and Coatings

 Intent To reduce the quantity of indoor air contaminants that are odorous, irritating and/or harmful to the comfort and well-being of
installers and occupants. 
 LEED-CS 150 Second has complied with the applicable volatile organic compound (VOC) requirements for all paints and
coatings installed within the weather barrier for the base building. As a result, the base building has provided a healthy indoor environment for tenants as they commence occupancy in their space. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by ensuring that all paints and coatings installed within the tenant space
comply with the applicable VOC limits. 
 IEQc4.3: Low-Emitting Materials – Flooring Systems 

Intent To reduce the quantity of indoor air contaminants that are odorous, irritating and/or harmful to the comfort and well-being of installers and
occupants. 
 LEED-CS 150 Second has complied with the applicable standards for all flooring systems installed within the weather barrier for the
base building. As a result, the base building has provided a healthy indoor environment for tenants as they commence occupancy for their space. 
 LEED-CI
Tenants attempting LEED-CI at 150 Second may achieve one point by ensuring that all flooring systems installed within the tenant space comply with the applicable standards. 

IEQc4.4: Low-Emitting Materials – Composite Wood and Agrifiber Product 

Intent To reduce the quantity of indoor air contaminant that are odorous, irritating and/ or harmful to the comfort and well-being of installers and
occupants. 

  
 



 
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 LEED-CS All composite wood and agrifiber products used on the interior of 150 Second have contained no
added urea-formaldehyde resins for the base building. As a result, the base building has provided a healthy indoor environment for tenants as they commence occupancy in their space. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by ensuring that all composite wood and agrifiber products installed within
tenant space contain no added urea-formaldehyde resins. 
 IEQc4.5: Low-Emitting Materials – Systems Furniture and Seating (LEED-CI Only) 

Intent To reduce the quantity of indoor air contaminants that are odorous, irritating and/or harmful to the comfort and well-being of installers and
occupants. 
 LEED-CS No related LEED-CS credit. 

LEED CI Tenants attempting LEED-CI at 150 Second may achieve one point by ensuring that all systems furniture and seating installed within the tenant
space comply with the applicable standards. 
 IEQc5: Indoor Chemical and Pollutant Source Control 

Intent To minimize building occupant exposure to potentially hazardous particulates and chemical pollutants. 

LEED-CS 150 Second has complied with the applicable measures for indoor chemical and pollutant source control for the base building. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by minimizing and controlling the entry of pollutants into the tenant space
through the employment of all applicable requirements of LEED-CI IEQc5: Indoor Chemical and Pollutant Source Control. The base building has provided a permanent entryway system at all major entrances, sufficient exhaust and sealing of housekeeping
and janitorial rooms, MERV-13 filtration on air handling units and closed containment systems for all hazardous liquid wastes. In addition, tenants are required to provide a 10-foot long entryway system for all main entrances. 

  
 



 
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 IEQc6.1: Controllability of Systems – Lighting 

Intent To provide a high level of lighting system control by individual occupants or groups in multi-occupant spaces (e.g., classrooms and conference
areas) and promote their productivity, comfort and well-being. 
 LEED-CS There is no related LEED-CS credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by providing individual lighting control for at least 90% of occupants of the
tenant space and for all multi-occupant spaces. 
 IEQc6: Controllability of Systems – Thermal Comfort (LEED-CI, IEQc6.2) 

Intent To provide a high level of thermal comfort control by individual occupants or groups in multi-occupant spaces (e.g. classrooms and conference
areas) and promote their productivity, comfort and well-being. 
 LEED-CS 150 Second did not pursue this credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second may achieve one point by providing individual thermal comfort controls for at least 50% of occupants
of the tenant space and for all multi-occupant spaces. 
 IEQc7: Thermal Comfort – Design (LEED-CI, IEQc7.1) 

Intent To provide a comfortable thermal environment that promotes occupant productivity and well-being. 

LEED-CS 150 Second has designed and installed the HVAC system and building envelope to meet the requirements of ASHRAE-55-2004 for the base building.
ASHRAE-55 requires the regulation of temperature and humidity levels within the building based on climate zone. The base building has provided the ability for tenants to comply with the requirements of ASHRAE 55-2004 during build-out of their tenant
space. 
 LEED-CI Tenants attempting LEED CI at 150 Second will achieve one point by demonstrating that the HVAC system meets the requirements of
ASHRAE-55-2004. 

  
 



 
 H-47 









 



 
  
  

 

 IEQc7.2: Thermal Comfort – Verification (LEED-CI Only) 

Intent To provide for the assessment of building occupants’ comfort over time. 

LEED-CS There is no related LEED-CS credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second can achieve one point by meeting the following requirements: 

 

	•	 	Achieving IEQc7.1 

  

	•	 	Providing a permanent monitoring system and process for corrective action to ensure that building performance meets the desired comfort criteria. 


 

	•	 	Conduct a thermal comfort survey of tenant space occupants within 6-18 months after occupancy. 

 IEQc8.1:
Daylight and Views – Daylight 
 Intent To provide occupants with a connection between indoor spaces and the outdoors through the
introduction of daylight and views into the regularly occupied areas of the building. 
 LEED-CS 150 Second did not pursue this credit. 

LEED-CI Tenants attempting LEED-CI at 150 Second will achieve one point by providing sufficient daylight to at least 75% of regularly spaces. To do so
tenants must be sure that their fit-out does not compromise the daylight provided by the base building, new simulations may need to be run. 
 IEQc8.2:
Daylight and Views – Views 
 Intent To provide occupants with a connection between indoor spaces and the outdoors through the introduction
of daylight and views into the regularly occupied areas of the building. 
 LEED-CS 150 Second has achieved direct views to the outdoor environment
through vision glazing for 91% of regularly occupied areas. The calculation of views for tenant spaces was done using a feasible tenant layout per the default occupancy counts. 

  
 



 
 H-48 









 



 
  
  

 

 LEED-CI Tenants attempting LEED-CI at 150 Second will achieve one point by providing direct views to
the outdoor environment through vision glazing for at least 90% of regularly occupied areas. To do so tenants must be sure that their fit-out does not compromise the views provided by the base building. Tenants should consider using an open plan,
desk partitions less than 42” in height in areas where views to the outside area possible, and glass partitions around common meeting areas. 

Innovation in Design (ID) 
 IDc1: Innovation in Design

 Intent To provide design teams and projects the opportunity to be awarded points for exceptional performance above the requirements set by LEED
and to develop innovation ideas in green building categories not specifically addressed by LEED. 
 LEED-CS 150 Second has four points in the LEED ID
category: 
  

	•	 	The base building has achieved exemplary performance under SSc4.1. 

  

	•	 	The base building has achieved exemplary performance under MRc2. 

  

	•	 	The base building has achieved exemplary performance under SSc2. 

  

	•	 	The base building participated in Pilot Credit 12 Reduced Automobile Dependence. 

 LEED-CI Tenants
attempting LEED-CI at 150 Second are encouraged to achieve all four ID credits through creative design and management of their built-out space. 
 IDc2:
LEED Accredited Professional 
 Intent To support and encourage the design integration required by LEED green buildings and to streamline the
application and certification process. 
 LEED-CS 150 Second has accomplished this through the participation of many LEED Accredited Professionals on
the design team and a sustainability consultant. The use of a LEED-AP as a responsible member of the design team for the base building and any tenant improvements will help ensure that the design and material specifications for the project will
properly address the established sustainable design criteria for the project. 
 LEED-CI Tenants attempting LEED-CI at 150 Second are encouraged to
include at least one principle participant on the project team, who has successfully completed the LEED Accredited Professional exam. Tenants can achieve one point for LEED-CI. 

  
 



 
 H-49 









 



 
  
  

 

 Appendix A: Reference Material 

Tenants should refer to the link below for a reference guide for the LEED 2009 for Commercial Interiors (LEED-CI) Rating System.
http://www.usgbc.org/ShowFile.aspx?DocumentID=5543 
 For reference, tenants should see to the LEED-CI 2009 Scorecard below. 

 
 



 

  
 



 
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 EXHIBIT I TO LEASE 

PARKING PLAN 

  
 I-1 








 



 

  








 EXHIBIT J TO LEASE 

RULES AND REGULATIONS 
 Tenant (and
tenant employees and contractors) shall faithfully observe and comply with the following Rules & Regulations: 
  

	 	1.	The sidewalks, entrances, service elevator lobby, corridors, stairwells, and fire exits of the building shall not be encumbered by any tenant or its agents, employees, licensees or guests or shall be used for
tenant’s premises provided that the stairwells may be so used. 

  

	 	2.	All deliveries to and removals from the building of furniture, equipment and supplies shall be by way of the loading dock – a platform (delivery entrance) located at the ground level of the building and accessible
from the street and then only during such hours as may be prescribed by the owner’s representative (Monday through Friday, 7AM – 5PM). During such hours there shall be no separate charge to tenant for the normal use of the loading dock or
freight elevator. Tenant shall be responsible for any loss, cost or damage suffered or incurred as a result of or arising from deliveries and/or removals after such hours. 


 

	 	3.	The loading dock and service elevator are for pick ups and deliveries only. Due to limited space at the loading dock, there is a vehicle parking limit of thirty (30) minutes, provided other deliveries are waiting,
unless special arrangements are made with the Property Management Office. Persons using service elevators will sign in at the security desk in the main lobby and be issued a floor pass. Each tenant will supply a list of authorized employees that
require access to the freight elevators. 

  

	 	4.	All incoming and outgoing shipments must be moved directly, by the delivery or pick up agent from the delivery entrance: such shipments will not be held at the delivery entrance. Building operating personnel are not
authorized to sign receipt for shipments to or from the building. 

  

	 	5.	Furniture, equipment and supplies and other packaged materials and items requiring the use of a hand truck, pallet truck or other type of wheeled transport, shall be moved only upon the service elevator.


  

	 	6.	All large deliveries, pick ups, moves and removal of demolition materials must be transported on the service elevator after hours, with prior approval of the owner’s representative and at the expense
of the tenant. The removal of demolition material and the delivery of sheet rock will require the smoke detectors in the freight elevators to be disabled. 


  
 J-1 









	 	7.	No hand truck, pallet truck or other type of wheeled transport shall be used in the lobbies, corridors or elevators of the building other than in the loading dock corridor to and including the freight elevator.


  

	 	8.	The owner’s representative reserves the right to inspect all items to be brought into the building and to exclude from the building all items which violate any provision of the rules and regulations or which may,
in the reasonable judgment of the owner’s representative, constitute a hazard or danger to the building, its equipment or occupants. 

  

	 	9.	Any damage to the building or any part thereof caused by the moving in our out of the building of furniture, equipment, supplies, or other items, shall be repaired by the owner’s representative at the expense of
the tenant responsible. 

  

	 	10.	Tenant shall notify the property management office when safes or other heavy equipment, except in the ordinary course of tenant’s business operations in accordance with its permitted use, are to be taken in or out
of the building, and such moving shall only be done after written permission is obtained from the property management office on such conditions, as the property management office shall require. Additional costs related to the installation of such
equipment, shall, as for elevator use or window removal, will be borne by tenant. 

  

	 	11.	All construction and demolition work requires a written request to be approved by the property management office who will act reasonably in connection therewith. Tenant and tenant’s contractor will be required to
follow the 150 Second Street Tenant Improvement Rules and Regulations that is available upon request at the property management office. Upon completion of approved work, if applicable, Tenant must provide “As-Built” drawings in both CAD
and black line form to the owner’s representative. 

  

	 	12.	Access to the area above the ceiling must be scheduled and approved by the property management office. All ceiling tiles must be back in place by the end of the working day. 


 

	 	13.	The property management office reserves the right to control and operate the public portions of the building and the public facilities, as well as the facilities furnished for the common use of the tenants, in such
manner as they deem best for the benefit of the tenants. 

  

	 	14.	The property management office reserves the right to exclude from the building, during non-business hours, all persons who do not present a valid building access photo id card that are not otherwise escorted by a Tenant
representative. 


  
 J-2 









	 	15.	The property management office must be given advance written notification of any after-hour functions requiring access via loading dock or building services. Tenant shall reimburse the owner’s representative for
any third party out of pocket costs incurred in connection with these services. 

  

	 	16.	No additional locks or bolts of any kind shall be placed upon any of the doors in any tenant’s premises and no lock on any door therein shall be changed or altered in any respect without property management
approval. In the case where tenant has equipment in the MEP rooms, card readers are to be installed by tenant, and a room access list provided to building management. 


 

	 	17.	No acids, vapors, or other materials shall be discharged into non-designated waste lines, vents or flues of the building. The water wash closets and other plumbing fixtures in or serving any tenant’s premises (not
specifically designed for this purpose) shall not be used for any purpose other than that for which they were designed or constructed, and no sweeping shall be deposited therein. The property management office shall repair any damage resulting to
the same from misuse by a tenant, at the expense of the tenant. 

  

	 	18.	If a tenant’s premises becomes infested with vermin, such tenant, at its sole cost and expense, unless it is clearly determined that the same has been caused entirely by others, shall cause it premises to be
exterminated by such exterminators as shall be approved by the property management office at such times and to such extent as the property management office deems necessary. 


 

	 	19.	No part of the tenant’s premises shall be occupied at any time as sleeping quarters and no part of the building shall be used for gambling or for any immoral or unlawful purposes or practices. No intoxicating
liquor shall be sold in any part of the building unless allowed by the lease agreement. 

  

	 	20.	No animals or birds, bicycles, skate boards, in-line skater or other vehicles shall be allowed in the corridors, lobbies, elevators, sidewalks, walkways, gardens, or elsewhere in or around the building (provided that
animals related to vivarium usage may be housed in the vivarium in tenant’s premises and transported in the freight elevator). Bicycle storage is available at the designated areas in the garage and at the front entrance by the canopy.


  

	 	21.	Canvassing, soliciting or peddling in the building is prohibited and each tenant shall cooperate to prevent the same. 

  

	 	22.	A building directory with the names of the tenants will be provided and maintained by the property management office. The property management office at the tenant’s expense will make changes in the directory,
within a reasonable time period after written notice from the tenant. 


  
 J-3 









	 	23.	Tenants may be requested to assign from their employees, personnel to perform specific tasks required by the building’s emergency evacuation plan. Person so assigned shall be made available from time to time for
instructions by the building life safety director. 

  

	 	24.	Access to building tele/com centers and closets will be provided by building security only. Anyone requesting access must have a valid id from the telecommunication company that employs them or be listed on the approved
access list that is maintained at the property management office. Tenant may elect to install a card reader and provide documentation of appropriate personnel training to allow authorization for room access. 


 

	 	25.	Building maintenance will provide access to the building electric closets. Tenants will be required to notify the property management office by electronic mail should a vendor require access. All tenant vendors must
have a valid id from the company that employees them or be listed on the approved access list that is maintained at the property management office. Tenant may elect to install a card reader and provide documentation of appropriate personnel training
to allow authorization for room access. 

  

	 	26.	Portable electric heaters, fans or desktop heating appliances (coffee cup warmers) are not allowed inside any tenant spaces or common areas within the building, unless approved by the property management office.


  

	 	27.	Prior written approval, which shall be at the sole discretion of the property management office, must be obtained for installation of any window shades, blinds, drapes or any other window treatment of any kind; provided
however, the foregoing restriction shall not apply to any of such items that are installed as part of Tenant’s Work in conformity with the Plans. 

  

	 	28.	Plumbing, fixtures and appliances shall be used only for the purpose for which constructed, no other unsuitable material shall be placed therein. 


 

	 	29.	Owner and property management office shall have the right to prescribe the weight and position of heavy equipment or objects, which may overstress any portion of the floors of the premises. All damage done to the
building by the improper placing of such heavy items will be repaired at the sole expense of the tenant. 

  

	 	30.	No nails, hooks or screws shall be driven into or inserted in any part of the building except as approved by the property management office, permitted by tenant’s lease, or as reasonably necessary to permit tenant
to hang pictures and other wall decorations or wall hangings (e.g., whiteboards, corkboards, signs, shelves, etc.) within the premises. 


  
 J-4 









	 	31.	Tenant shall comply with all requirements necessary for the security of the premises, including the use or property removal passes for the removal of office equipment/packages, and use of security control cards for
access to the building at all times. 

  

	 	32.	Smoking is not permitted in the 150 Second Street common areas including exterior entrances, vestibules, corridors, restrooms, stairwells and parking garage. Additionally, smoking is not allowed within 25 feet of the
front of the entrance of the building as well as the loading dock entrance. Tenant must comply with requests by the owner’s representative concerning informing their employees of items of importance to the owner. 


 

	 	33.	All doors opening to public corridors shall be kept closed at all times except for normal ingress and egress to the premises, unless electrical holdbacks have been installed. 


 

	 	34.	Owner reserves the right to close and keep locked all entrance and exit doors during hours when the building is closed. Access to the building may be refused unless person seeking access has proper identification or has
previously arranged a pass for access to the building. The owner and its representative shall in no case be liable for damages for any error with regard to the admission to or exclusion from the building of any person. In case of invasion, mob,
riot, public excitement or other commotion, owner reserves the right to prevent access to the building during the continuance of it by any means it deems appropriate for the safety and protection of life and property. 


 

	 	35.	No furniture, freight, equipment or other bulky matter will be brought into or removed from the building or carried up or down in elevators, except upon prior notice to the property management office and in such manner,
in such specific elevator, and between such hours as shall be reasonably designated by the owner; provided however, (i) the foregoing restrictions shall not apply to items brought into the building in connection with Tenant’s Work,
or (ii) for items delivered to the Premises on a recurring basis, such approval need only be obtained from Landlord once. Tenant shall provide the property management office with reasonable prior notice of the need to utilize the elevator for
any such purpose, so as to provide owner with a reasonable period to schedule such use and to install such padding or take such other actions or prescribe such procedures as are appropriate to protect against damage to the elevators or other parts
of the building. 

  

	 	36.	Tenant shall not disturb, solicit or canvass any occupant of the building and shall cooperate with the owner or owner’s agent to prevent it. 


 

	 	37.	The toilet rooms, urinals, wash bowls and other apparatus shall not be used for any purpose other than that for which they were constructed and no foreign substance of any kind whatsoever shall be thrown therein.



  
 J-5 









	 	38.	Tenant shall not use any method of heating or air conditioning other than that which is supplied by the owner without the prior written consent of the owner. 


 

	 	39.	Cooking shall not be permitted or done by any tenant on the premises, nor shall the premises be used for the storage of merchandise for lodging of for any improper objectionable or immoral purposes. Notwithstanding the
foregoing, laboratory approved equipment and microwave ovens and/or small toaster ovens may be used on the premises for heating food and brewing coffee, tea, hot chocolate and similar beverages, provided that such use is in accordance with
applicable federal, state and city laws, codes, ordinances, rules and regulations, and does not cause odors which are objectionable to owner and other tenants. 

  

	 	40.	Owner will approve where and how telephone wires are to be introduced to the premises. No boring or cutting for wires shall be allowed without the consent of the owner. The location of telephone, call boxes and other
office equipment affixed to the premises shall be subject to the approval of the owner. 

  

	 	41.	Tenant, it’s employees and agents shall not loiter in the entrances or corridors, nor in any way obstruct the sidewalks, lobby, halls, stairwells or elevators and shall use the same only as a means of ingress and
egress for the premises. 

  

	 	42.	Tenant shall store all trash and garbage within the interior of the premises. No material shall be placed in the trash boxes or receptacles if material is of such nature that it may not be disposed of in the ordinary
and customary manner of removing and disposing of trash and garbage in the City of Cambridge without violation of any law or ordinance governing such disposal. All trash, garbage and refuse disposal shall be made only through entryways and elevators
provided for such purposes at such times, as owner shall designate. Building has a compactor that is maintained and operated by building management. 

  

	 	43.	Tenant shall assume any and all responsibility for protecting the premises form theft, robbery and pilferage, which includes keeping doors locked and other means of entry to the premises closed, when the premises are
not occupied. 

  

	 	44.	Owner may waive any one or more of these Rules and Regulations for the benefit of any particular tenant or tenants. This shall not prevent the owner from thereafter enforcing any such Rules and Regulations against any
or all tenants of the building. 


  
 J-6 









	 	45.	No awnings or other projects shall be attached to the outside walls of the building without the prior written consent of the owner. No curtains, blinds, shades or screens shall be attached to or hung in, or used in
connection with any window or door of the premises without prior written consent of the owner. All electrical ceiling fixtures hung in offices or spaces along the perimeter of the building must be fluorescent and/or of a quality, type, design and
bulb color approved by the owner. 

  

	 	46.	Food vendors shall be allowed in the 150 Second Street building upon receipt of a written request from the tenant. The food vendor shall service only the tenants that have a written request on file in the property
management office. Under no circumstances shall the food vendor display their products in a public or common area including corridors and elevator lobbies. Any failure to comply with this rule shall result in the immediate permanent withdrawal of
the vendor from 150 Second Street. 

  

	 	47.	Tenant shall comply with any non smoking ordinances adopted by any applicable governmental authority. In addition, owner reserves the right to designate in owner’s sole discretion, the only outside areas of the
premises where smoking shall be permitted. 

  

	 	48.	Owner and its agent have the right to evacuate 150 Second Street in the event of an emergency or catastrophe. 

  

	 	49.	Provided such changes are not in conflict with the terms of this Lease and that Landlord provides prior written notice of such change, Owner and its agent reserves the right at any time to change or rescind any one or
more of these Rule and Regulations or to make such other further reasonable Rules and Regulations as in owner’s judgment may from time to time be necessary for the management, safety, care and cleanliness of the premises and building, and for
the preservation of good order therein, as well as for the convenience of other occupants and tenants. Owner shall not be responsible to tenant or to any other person for the non-observance of the Rules and Regulations and tenant shall agree to
abide by these rules as a condition of its occupancy of the premises. 


  
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	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 340

  

 SECOND AMENDMENT TO LEASE 

This Second Amendment to Lease (“Second Amendment”) is made as of June 9, 2014, by and between ARE-MA REGION
NO. 50, LLC, a Delaware limited liability company (“Landlord”), and BLUEBIRD BIO, INC., a Delaware corporation (“Tenant”). 

RECITALS 

A. Landlord’s predecessor in interest, 150 Second Street, LLC, and Tenant entered into that certain Lease Agreement dated as of
June 3, 2013, as amended by a First Amendment to Lease dated as of November 15, 2013 (the “Lease”), Tenant leased certain premises (the “Original Premises”) located at 150 Second Street, Cambridge,
Massachusetts more particularly described in the Lease. 
 B. Tenant desires to expand the Original Premises demised under the
Lease by adding approximately 9,869 rentable square feet (the “Expansion Space”) on the first floor of the Building, for a total rentable square footage from and after the Expansion Commencement Date (as hereinafter defined) of
53,455 rentable square feet, and Landlord is willing to lease the same to Tenant on the terms herein set forth. 
 C. Landlord
and Tenant desire to amend the Lease to add the Expansion Space to the Premises demised under the Lease, to provide for the improvement of such space, and to address other matters more particularly set forth below. 

D. Capitalized terms used and not otherwise defined herein shall have the meanings ascribed to them in the Lease. 

AGREEMENT 
 Now,
therefore, the parties hereto agree that the Lease is amended as follows: 
 1. Expansion Space; Tenant’s Share.
From and after the Expansion Commencement Date: (a) the Premises demised under the Lease shall be expanded to include the Expansion Space, consisting for all purposes of the Lease of 9,869 rentable square feet on the first floor of the
Building, as shown on Exhibit A, together with the additional Tenant’s Share of mechanical, pH and lab-related storage located in the penthouse, first floor and lower level of the Building, as more particularly described in
Section 7 below; (b) Tenant’s Share for all purposes of the Lease shall be 43.39%; and (c) except as specifically set forth herein to the contrary, all provisions of the Lease, including, but not limited to Exhibits E, F
and H of the Lease, shall apply to the Expansion Space.  
 2. Delivery of Expansion Space. Tenant shall accept
the Expansion Space in their condition as of the date hereof, subject to the terms of Exhibit B (Work Letter) and all applicable Legal Requirements. Tenant’s taking possession of the Expansion Space shall be conclusive evidence that
Tenant accepts the Expansion Space and that the Expansion Space was in good condition at the time possession was taken, subject to the provisions of the Work Letter. Tenant agrees and acknowledges that neither Landlord nor any agent of Landlord has
made any representation or warranty with respect to the condition of all or any portion of the Expansion Space, and/or the suitability of the Expansion Space for the conduct of Tenant’s business. Tenant shall have a right of access to the
Expansion Space for the purpose of installation of the Tenant 

  
 © All Rights
Reserved 2001 Alexandria Real Estate Equities, Inc. 
 CONFIDENTIAL – DO NOT COPY 









  

			
	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 341

  

 
Improvements from and after the date on which Tenant delivers to Landlord the TI Permit (as defined in the Work Letter), which occupancy shall be subject to all of the terms and conditions of the
Lease, as amended hereby, except that Rent as to the Expansion Space shall not commence until the Expansion Rent Commencement Date. 

3. Expansion Commencement Date; Expansion Rent Commencement Date. The Term of the Lease with respect to the Expansion
Space shall commence on the first to occur of: (a) Substantial Completion of the Tenant Improvements (as defined in Exhibit B); and (b) September 1, 2014 (the “Expansion Commencement Date”). The date for
commencement of Base Rent and Additional Rent with respect to the Expansion Space (the “Expansion Rent Commencement Date”) shall be the date which is 90 days following the Expansion Commencement Date (but no later than
December 1, 2014). The Term of the Lease as to the entirety of the Premises shall expire on December 31, 2022. The Extension Right set forth in Article 28 of the Lease shall be exercisable in accordance with Article 28 only
as to the entirety of the Premises. 
 4. Rent for Expansion Space. From and after the Expansion Rent
Commencement Date, Base Rent, Administration Rent, and Additional Rent shall be payable with respect to the Expansion Space in accordance with the terms of the Lease. Accordingly, the Base Rent for the Premises (including the Original Premises and
the Expansion Space) shall be paid in accordance with the following table (which table replaces the table set forth in Section 1.1 of the Lease): 
  

							
	 Period
	 	 Rate per RSF
	 	 Annual Base Rent
	 	 Monthly Base

Rent

				
	1/1/2014 to Expansion Rent Commencement Date*	 	$57.50	 	$2,506,195.00	 	$208,849.58
				
	Expansion Rent Commencement Date to 12/31/2014	 	$57.50	 	$3,073,662.50	 	$256,138.54
				
	 1/1/2015-12/31/2015
	 	$59.22	 	$3,165,605.10	 	$263,800.42
				
	 1/1/2016-12/31/2016
	 	$61.00	 	$3,260,755.00	 	$271,729.58
				
	 1/1/2017-12/31/2017
	 	$62.83	 	$3,358,577.60	 	$279,881.46
				
	 1/1/2018-12/31/2018
	 	$64.72	 	$3,459,607.60	 	$288,300.63
				
	 1/1/2019-12/31/2019
	 	$66.66	 	$3,563,310.30	 	$296,942.52
				
	 1/1/2020-12/31/2020
	 	$68.66	 	$3,670,220.30	 	$305,851.69
				
	 1/1/2021-12/31/2021
	 	$70.72	 	$3,780,337.60	 	$315,028.13
				
	 1/1/2022-12/31/2022
	 	$72.84	 	$3,893,662.20	 	$324,471.85


  
 © All Rights
Reserved 2001 Alexandria Real Estate Equities, Inc. 
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	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 342

  

 *Notwithstanding anything in this Section of the Lease to the contrary, Tenant shall be entitled to an
abatement of Base Rent with respect to the Original Premises in the amount of $208,849.58 per month for six (6) consecutive full calendar months of the Base Term beginning on the Lease Commencement Date, subject to the terms and conditions set
forth in Section 4.2 of the Lease. 
 5. Memorial Drive Rent Savings Event. Pursuant to
Section 4.2 of the Lease, Landlord and Tenant split Tenant’s net rent savings under the Memorial Drive Lease on a 60% to Landlord and 40% to Tenant basis. The amount of such savings allocated to Landlord is applied as a credit
against the Rent Abatement provided to Tenant during the Base Rent Abatement Period (and, accordingly, constitutes an additional rent obligation to Landlord in the same amount), as more particularly set forth in Section 4.2 of the Lease.
Tenant represents to Landlord that there have been and may be Memorial Drive Rent Savings Events, which have resulted and may in the future result in additional rent payable to Landlord hereunder as follows: (a) $9,066.96 for the month of
March, 2014 (receipt of which is hereby acknowledged by Landlord); and (b) to the extent actually received by Tenant only, $31,534.14 per month for the period from April 1, 2014 through March 31, 2015, payable monthly as provided in
Section 4.2 of the Lease. 
 6. Parking. Tenant shall have as appurtenant to the Expansion Space 6 parking
spaces in the Building garage, and 4 surface parking spaces, in accordance with Section 7.1 of the Lease. Tenant hereby confirms that, from and after the Expansion Space Commencement Date, Tenant’s commitment for parking for
calendar year 2014 shall be a total of 34 parking spaces in the Building garage, and 19 surface parking spaces. 
 7. Additional
Space. As a result of the increase in Tenant’s Share to 43.39%, Tenant’s Share of the 4,651 square feet of Storage Space in the Building’s Basement Storage Room is now 2,018 square feet of Storage Space, in accordance with and
subject to the terms of Section 2.2 of the Lease. The expansion of the Premises with space associated with the Expansion Space is comprised of: (a) the 98.5 rentable square feet in the Storage Room in the location shown on Exhibit
A-1, (b) an additional 172 rentable square feet in a location to be reasonably approved by Landlord in the lower level (basement/garage level) of the Building, as shown on Exhibit A-2; (c) an additional 372 rentable square feet
of storage space in a location to be reasonably approved by Landlord in the basement Storage Space, as shown on Exhibit A-3; and (d) an additional 171 rentable square feet in a location to be reasonably approved by Landlord on the penthouse of
the Building, as shown on Exhibit A-4.  
 8. Miscellaneous. 

a. This Second Amendment is the entire agreement between the parties with respect to the subject matter hereof and supersedes all prior and
contemporaneous oral and written agreements and discussions. This Second Amendment may be amended only by an agreement in writing, signed by the parties hereto. 

b. This Second Amendment is binding upon and shall inure to the benefit of the parties hereto and their respective permitted successors in
interest. 
 c. This Second Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of
which when taken together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to any
other counterpart identical thereto except having additional signature pages executed by other parties to this Second Amendment attached thereto. 

  
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	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 343

  

 d. Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent
or other person (collectively “Broker”) in connection with this transaction other than Jones Lang LaSalle and Colliers International, and that no Broker, other than Jones Lang LaSalle and Colliers International, who shall be paid by
Landlord pursuant to a separate Agreement, brought about this transaction. Landlord and Tenant each hereby agree to indemnify and hold the other harmless from and against any claims by any Broker (other than Jones Lang LaSalle and Colliers
International) claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this leasing transaction. 

e. As amended and/or modified by this Second Amendment, the Lease is hereby ratified and confirmed and all other terms of the Lease shall
remain in full force and effect, unaltered and unchanged by this Second Amendment. In the event of any conflict between the provisions of this Second Amendment and the provisions of the Lease, the provisions of this Second Amendment shall prevail.
Whether or not specifically amended by this Second Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this Second Amendment. 

(Signatures on Next Page) 

  
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	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 344

  

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment as of the day and year
first above written. 
  

							
	TENANT:
	
	 BLUEBIRD BIO, INC.,
 a Delaware
corporation

		
	By:	 	/s/ Jason F. Cole
	Name:	 	Jason F. Cole
	Its:	 	SVP, General Counsel
	
	LANDLORD:
	
	ARE-MA REGION NO. 50, LLC, a Delaware limited liability company
	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership, member
		 	By:	 	 ARE-QRS CORP.,
 a Maryland
corporation,
 general partner

				
		 		 	By:	 	/s/ Eric S. Johnson
		 		 	Name:	 	Eric S. Johnson
		 		 	Its:	 	Vice President
		 		 	Real Estate Legal Affairs



  
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	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 345

  

 EXHIBIT A 

Plan of Expansion Space 

See attached 

  
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 EXHIBIT A-1 
  





 







 EXHIBIT A-2 
  





 







 EXHIBIT A-3 
  





 
  







 EXHIBIT A-4 
  





 
  








  

			
	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 351

  

 EXHIBIT B TO SECOND AMENDMENT TO LEASE 

[Tenant Build] 

WORK LETTER 
 THIS
WORK LETTER (this “Work Letter”) is incorporated into that certain Second Amendment to Lease (the “Lease”) dated as of June 9, 2014 by and between ARE-MA REGION NO. 50, LLC, a Delaware limited liability company
(“Landlord”), and Bluebird Bio, Inc., a Delaware corporation (“Tenant”). Any initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 

1. General Requirements. 
 a.
Tenant’s Authorized Representative. Tenant designates Stacy Gilroy and Eric Sullivan (either such individual acting alone, “Tenant’s Representative”) as the only persons authorized to act for Tenant pursuant to this Work
Letter. Landlord shall not be obligated to respond to or act upon any request, approval, inquiry or other communication (“Communication”) from or on behalf of Tenant in connection with this Work Letter unless such Communication is in
writing from Tenant’s Representative. Tenant may change either of Tenant’s Representatives at any time upon not less than 5 business days advance written notice to Landlord. 

b. Landlord’s Authorized Representative. Landlord designates Jeff McComish, Joe Maguire, and William DePippo (any such individual
acting alone, “Landlord’s Representative”) as the only persons authorized to act for Landlord pursuant to this Work Letter. Tenant shall not be obligated to respond to or act upon any request, approval, inquiry or other Communication
from or on behalf of Landlord in connection with this Work Letter unless such Communication is in writing from Landlord’s Representative. Landlord may change any of Landlord’s Representatives at any time upon not less than 5 business days
advance written notice to Tenant. 
 c. Architects, Consultants and Contractors. Landlord and Tenant hereby acknowledge and agree that
the architect (the “TI Architect”) for the Tenant Improvements (as defined in Section 2(a) below), the general contractor and any subcontractors for the Tenant Improvements shall be selected by Tenant, subject to Landlord’s
approval, which approval shall not be unreasonably withheld, conditioned or delayed. Tenant shall use AHA Consulting Engineers for the MEP documents for the Tenant Improvements, and may use Lab Architects as the TI Architect, The Richmond Group as
Tenant’s general contractor, and Mike Fletcher from Fletcher Martin Corporation as Project Manager. Landlord shall be named a third party beneficiary of any contract entered into by Tenant with the TI Architect, any consultant, any contractor
or any subcontractor, and of any warranty made by any contractor or any subcontractor. 
 2. Tenant Improvements. 

a. Tenant Improvements Defined. As used herein, “Tenant Improvements” shall mean all improvements to the Premises desired by
Tenant of a fixed and permanent nature. Other than funding the TI Allowance (as defined below) as provided herein, and the installation of the “Demising Wall” (as hereinafter defined), Landlord shall not have any obligation whatsoever with
respect to the finishing of the Premises for Tenant’s use and occupancy. Landlord hereby agrees to install, at Landlord’s sole expense, a wall demising the Expansion Space from the adjacent first floor premises in accordance with the
specification attached hereto as Exhibit B-1 (“Demising Wall”) on a schedule which will coordinate with Tenant’s improvements in the Expansion Space and with the construction of
improvements in the adjacent tenant space. 

  
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	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 352

  

 b. Tenant’s Space Plans. Tenant shall deliver to Landlord schematic drawings
and outline specifications (the “TI Design Drawings”) detailing Tenant’s requirements for the Tenant Improvements within 60 days of the date hereof. Not more than 10 business days thereafter, Landlord shall deliver to Tenant the
written objections, questions or comments of Landlord and the TI Architect with regard to the TI Design Drawings. Tenant shall cause the TI Design Drawings to be revised to address such written comments and shall resubmit said drawings to Landlord
for approval within 5 business days thereafter. Such process shall continue until Landlord has approved the TI Design Drawings. 

c. Working Drawings. Not later than 15 business days following the approval of the TI Design Drawings by Landlord, Tenant shall
cause the TI Architect to prepare and deliver to Landlord for review and comment construction plans, specifications and drawings for the Tenant Improvements (“TI Construction Drawings”), which TI Construction Drawings shall be prepared
substantially in accordance with the TI Design Drawings. Tenant shall be solely responsible for ensuring that the TI Construction Drawings reflect Tenant’s requirements for the Tenant Improvements. Landlord shall deliver its written comments on
the TI Construction Drawings to Tenant not later than 10 business days after Landlord’s receipt of the same; provided, however, that Landlord may not disapprove any matter that is consistent with the TI Design Drawings. Tenant and the TI
Architect shall consider all such comments in good faith and shall, within 10 business days after receipt, notify Landlord how Tenant proposes to respond to such comments. Any disputes in connection with such comments shall be resolved in accordance
with Section 2(d) hereof. Provided that the design reflected in the TI Construction Drawings is consistent with the TI Design Drawings, Landlord shall approve the TI Construction Drawings submitted by Tenant. Once approved by Landlord, subject
to the provisions of Section 4 below, Tenant shall not materially modify the TI Construction Drawings except as may be reasonably required in connection with the issuance of the TI Permit (as defined in Section 3(a) below). 

d. Approval and Completion. If any dispute regarding the design of the Tenant Improvements is not settled within 10 business days
after notice of such dispute is delivered by one party to the other, Tenant may make the final decision regarding the design of the Tenant Improvements, provided (i) Tenant acts reasonably and such final decision is either consistent with or a
compromise between Landlord’s and Tenant’s positions with respect to such dispute, (ii) that all costs and expenses resulting from any such decision by Tenant shall be payable out of the TI Allowance (as defined in Section 5(d)
below), and (iii) Tenant’s decision will not affect the base Building, structural components of the Building or any Building systems (in which case Landlord shall make the final decision). Any changes to the TI Construction Drawings
following Landlord’s and Tenant’s approval of same requested by Tenant shall be processed as provided in Section 4 hereof. 

3. Performance of the Tenant Improvements. 

a. Commencement and Permitting of the Tenant Improvements. Tenant shall commence construction of the Tenant Improvements upon
obtaining and delivering to Landlord a building permit (the “TI Permit”) authorizing the construction of the Tenant Improvements consistent with the TI Construction Drawings approved by Landlord. The cost of obtaining the TI Permit shall
be payable from the TI Allowance. Landlord shall assist Tenant in obtaining the TI Permit. Prior to the commencement of the Tenant Improvements, Tenant shall deliver to Landlord a copy of any contract with Tenant’s contractors (including the TI
Architect), and certificates of insurance from any 

  
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	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 353

  

 
contractor performing any part of the Tenant Improvement evidencing industry standard commercial general liability, automotive liability, “builder’s risk”, and workers’
compensation insurance. Tenant shall cause the general contractor to provide a certificate of insurance naming Landlord, Alexandria Real Estate Equities, Inc., and Landlord’s lender (if any) as additional insureds for the general
contractor’s liability coverages required above. 
 b. Selection of Materials, Etc. Where more than one type of
material or structure is indicated on the TI Construction Drawings approved by Tenant and Landlord, the option will be within Tenant’s reasonable discretion if the matter concerns the Tenant Improvements, and within Landlord’s sole and
absolute subjective discretion if the matter concerns the structural components of the Building or any Building system. 
 c.
Tenant Liability. Tenant shall be responsible for correcting any deficiencies or defects in the Tenant Improvements.  

d. Substantial Completion. Tenant shall substantially complete or cause to be substantially completed the Tenant Improvements in
a good and workmanlike manner, in accordance with the TI Permit subject, in each case, to Minor Variations and normal “punch list” items of a non-material nature which do not interfere with the use of the Premises (“Substantial
Completion” or “Substantially Complete”). Upon Substantial Completion of the Tenant Improvements, Tenant shall require the TI Architect and the general contractor to execute and deliver, for the benefit of Tenant and Landlord, a
Certificate of Substantial Completion in the form of the American Institute of Architects (“AIA”) document G704. For purposes of this Work Letter, “Minor Variations” shall mean any modifications reasonably required: (i) to
comply with all applicable Legal Requirements and/or to obtain or to comply with any required permit (including the TI Permit); (ii) to comport with good design, engineering, and construction practices which are not material; or (iii) to
make reasonable adjustments for field deviations or conditions encountered during the construction of the Tenant Improvements. 
 4. Changes.
Any changes requested by Tenant to the Tenant Improvements after the delivery and approval by Landlord of the TI Design Drawings, shall be requested and instituted in accordance with the provisions of this Section 4 and shall be subject to the
written approval of Landlord, which approval shall not be unreasonably withheld, conditioned or delayed. 
 a. Tenant’s Right
to Request Changes. If Tenant shall request changes (“Changes”), Tenant shall request such Changes by notifying Landlord in writing in substantially the same form as the AIA standard change order form (a “Change Request”),
which Change Request shall detail the nature and extent of any such Change. Such Change Request must be signed by Tenant’s Representative. Landlord shall review and approve or disapprove such Change Request within 5 business days thereafter,
provided that Landlord’s approval shall not be unreasonably withheld, conditioned or delayed. 
 b. Implementation of
Changes. If Landlord approves such Change and Tenant deposits with Landlord any Excess TI Costs (as defined in Section 5(d) below) required in connection with such Change, Tenant may cause the approved Change to be instituted. If any TI
Permit modification or change is required as a result of such Change, Tenant shall promptly provide Landlord with a copy of such TI Permit modification or change. 

5. Costs. 
 a. Budget For
Tenant Improvements. Before the commencement of construction of the Tenant Improvements, Tenant shall obtain a detailed breakdown, by trade, of the costs incurred  

  
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	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 354

  

 
or that will be incurred, in connection with the design and construction of The Tenant Improvements (the “Budget”), and deliver a copy of the Budget to Landlord for Landlord’s
approval, which shall not be unreasonably withheld or delayed. The Budget shall be based upon the TI Construction Drawings approved by Landlord and shall include all of Landlord’s out-of-pocket costs, expenses and fees incurred by or on behalf
of Landlord arising from, out of, or in connection with, such monitoring of the construction of the Tenant Improvements, and shall be payable out of the TI Allowance (for avoidance of doubt, Landlord shall not be entitled to any project management
or oversight fees in connection with the Tenant Improvements). If the Budget is greater than the TI Allowance, Tenant shall be solely responsible for the timely payment of all amounts in excess of the TI Allowance. 

b. TI Allowance. Landlord shall provide to Tenant a tenant improvement allowance (“TI Allowance”) of $125.00 per
rentable square foot of the Expansion Space, or $1,233,625.00 in the aggregate. The TI Allowance shall be disbursed in accordance with this Work Letter. Tenant shall have no right to the use or benefit (including any reduction to Base Rent) of any
portion of the TI Allowance not required for the construction of (i) the Tenant Improvements described in the TI Construction Drawings approved pursuant to Section 2(d) or (ii) any Changes pursuant to Section 4. Tenant shall have
no right to any portion of the TI Allowance that is not disbursed before March 31, 2015.  
 c. Costs Includable in TI
Allowance. The TI Allowance shall be used solely for the payment of design, permits and construction costs in connection with the construction of the Tenant Improvements, including, without limitation, the cost of electrical power and other
utilities used in connection with the construction of the Tenant Improvements, the cost of preparing the TI Design Drawings and the TI Construction Drawings, all costs set forth in the Budget, and the cost of Changes (collectively, “TI
Costs”). Notwithstanding the foregoing, Tenant shall have the right to apply up to $10.00 per rentable square foot of the Expansion Space TI Allowance toward soft costs, including, but not limited to, furniture, fixtures and equipment,
telephone/data wiring, security access, architectural/design fees, in connection with the Expansion Space. 
 d. Excess TI
Costs. Landlord shall have no obligation to bear any portion of the cost of any of the Tenant Improvements except to the extent of the TI Allowance. Tenant shall be fully and solely liable for the timely payment of TI Costs and the cost of Minor
Variations in excess of the TI Allowance.  
 e. Payment for TI Costs. During the course of design and construction of
the Tenant Improvements, Landlord shall pay TI Costs once a month against a draw request in Landlord’s standard form, containing such certifications, lien waivers (including a conditional lien release for each progress payment and unconditional
lien releases for the prior month’s progress payments), inspection reports and other matters as Landlord customarily obtains, to the extent of Landlord’s approval thereof for payment, no later than 30 days following receipt of such draw
request. Upon completion of the Tenant Improvements (and prior to any final disbursement of the TI Allowance), Tenant shall deliver to Landlord: (i) sworn statements setting forth the names of all contractors and first tier subcontractors who
did the work and final, unconditional lien waivers from all such contractors and first tier subcontractors; (ii) as-built plans (one copy in print format and two copies in electronic CAD format) for such Tenant Improvements; (iii) a
certification of substantial completion in Form AIA G704, (iv) a certificate of occupancy for the Premises; and (v) copies of all operation and maintenance manuals and warranties affecting the Premises. 

  
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	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 355

  

 6. Miscellaneous. 

a. Consents. Whenever consent or approval of either party is required under this Work Letter, that party shall not unreasonably
withhold, condition or delay such consent or approval, except as may be expressly set forth herein to the contrary. 
 b.
Modification. No modification, waiver or amendment of this Work Letter or of any of its conditions or provisions shall be binding upon Landlord or Tenant unless in writing signed by Landlord and Tenant. 

c. Counterparts. This Work Letter may be executed in any number of counterparts but all counterparts taken together shall
constitute a single document. 
 d. Governing Law. This Work Letter shall be governed by, construed and enforced in
accordance with the internal laws of the state in which the Premises are located, without regard to choice of law principles of such State. 

e. Time of the Essence. Time is of the essence of this Work Letter and of each and all provisions thereof. 

f. Default. Notwithstanding anything set forth herein or in the Lease to the contrary, Landlord shall not have any obligation to
perform any work hereunder or to fund any portion of the TI Allowance during any period Tenant is in Default under the Lease. 

g. Severability. If any term or provision of this Work Letter is declared invalid or unenforceable, the remainder of this Work
Letter shall not be affected by such determination and shall continue to be valid and enforceable. 
 h. Merger. All
understandings and agreements, oral or written, heretofore made between the parties hereto and relating to Tenant’s Work are merged in this Work Letter, which alone (but inclusive of provisions of the Lease incorporated herein and the final
approved constructions drawings and specifications prepared pursuant hereto) fully and completely expresses the agreement between Landlord and Tenant with regard to the matters set forth in this Work Letter. 

i. Entire Agreement. This Work Letter is made as a part of and pursuant to the Lease and, together with the Lease, constitutes
the entire agreement of the parties with respect to the subject matter hereof. This Work Letter is subject to all of the terms and limitation set forth in the Lease, and neither party shall have any rights or remedies under this Work Letter separate
and apart from their respective remedies pursuant to the Lease. 
 [ Signatures on next page ] 

  
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	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 356

  

 IN WITNESS WHEREOF, Landlord and Tenant have executed this Work Letter to be effective on
the date first above written. 
  

			
	TENANT:
	
	 BLUEBIRD BIO, INC.,
 a Delaware
corporation

		
	By:	 	/s/ Jason F. Cole
	Name:	 	Jason F. Cole
	Its:	 	SVP, General Counsel


  

	
	LANDLORD:
	
	 ARE-MA REGION NO. 50, LLC,
 a Delaware limited
liability company

	 By:   ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership,
member

	 By:   ARE-QRS CORP., a Maryland corporation, general partner



  

			
	 By:
	 	/s/ Eric S. Johnson
	 Name:
	 	Eric S. Johnson
	 Its:
	 	Vice President
		 	Real Estate Legal Affairs



  
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	Second Amendment To Lease – Bluebird Bio/150 Second St., Cambridge MA	  	Page 357

  

 EXHIBIT B-1 

Specification for Demising Wall 
 The
Expansion Space shall be demised, per premises plan, with full height, one (1) hour fire-rated partition comprised of, 3-5/8” metal studs and one layer of 5/8” GWB each side. Partitions shall be sufficiently prepared for finish.


  
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 CONFIDENTIAL – DO NOT COPY