EXHIBIT
10.2


 


CONFIDENTIAL
TREATMENT


 


EPIX Medical, Inc. has
requested that the marked portions of this document be accorded confidential
treatment pursuant to Rule 24b-2 under the Securities Exchange Act of 1934.


 


 


Final Version


 


COLLABORATIVE RESEARCH AGREEMENT


 


between


 


EPIX


 


and


 


SCHERING


 

















 


TABLE OF CONTENTS


 


	
  1.

  	
  DEFINITIONS

  
	
   

  	
   

  	
   

  	
   

  
	
  2.

  	
  RESEARCH PROGRAM

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  2.1

  	
  Objectives
  of the Research Program; Term; Exclusivity

  
	
   

  	
  2.2

  	
  Obligations of the Parties

  
	
   

  	
   

  	
  2.2.1

  	
  Research Plan(s)

  
	
   

  	
   

  	
  2.2.2

  	
  Due Diligence;
  Commitment of FTE’s

  
	
   

  	
   

  	
  2.2.3

  	
  Information Exchange;
  Reports

  
	
   

  	
   

  	
  2.2.4

  	
  Supply of Proprietary
  Materials

  
	
   

  	
  2.3

  	
  Contract Services and Goods

  
	
   

  	
  2.4

  	
  Discovery of Lead Compounds

  
	
   

  	
   

  	
   

  	
   

  
	
  3.

  	
  RESEARCH FUNDING

  
	
   

  	
   

  
	
   

  	
  3.1

  	
  Payments
  by SCHERING

  
	
   

  	
  3.2

  	
  Loan
  by SCHERING to EPIX

  
	
   

  	
   

  	
   

  	
   

  
	
  4.

  	
  OPTION
  RIGHTS FOR DEVELOPMENT CANDIDATES AND JOINT TECHNOLOGY

  
	
   

  	
   

  
	
   

  	
  4.1

  	
  SCHERING
  License Option

  
	
   

  	
   

  	
  4.1.1

  	
  Option Grant

  
	
   

  	
   

  	
  4.1.2

  	
  Exercise of SCHERING Option

  
	
   

  	
  4.2

  	
  Failure to
  Exercise; EPIX License Option

  
	
   

  	
  4.3

  	
  Failure to
  Exercise the Option by both Parties

  
	
   

  	
  4.4

  	
  Joint
  Technology Option

  
	
   

  	
   

  	
   

  	
   

  
	
  5.

  	
  ADMINISTRATION OF
  THE COLLABORATION

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  5.1

  	
  Establishment and
  Function of RSC

  
	
   

  	
   

  	
  5.1.1

  	
  Membership

  
	
   

  	
   

  	
  5.1.2

  	
  Chair

  
	
   

  	
   

  	
  5.1.3

  	
  Minutes

  
	
   

  	
   

  	
  5.1.4

  	
  Responsibilities of the RSC

  
	
   

  	
   

  	
  5.1.5

  	
  RSC
  Dispute Resolution

  
	
   

  	
  5.2

  	
  Establishment
  and Function of Management Team

  
	
   

  	
   

  	
  5.2.1

  	
  Membership

  
	
   

  	
   

  	
  5.2.2

  	
  Chair

  
	
   

  	
   

  	
  5.2.3

  	
  Minutes

  
	
   

  	
   

  	
  5.2.4

  	
  Responsibilities of
  Management Team

  
	
   

  	
   

  	
  5.2.5

  	
  Management Team
  Dispute Resolution

  
								



 


i

















 


	 
	
   

  	
  5.3

  	
  Establishment of
  Project Team(s)

  
	 
	
   

  	
   

  	
   

  	
   

  
	 
	
  6.

  	
  DEVELOPMENT
  AND COMMERCIALIZATION OF DEVELOPMENT CANDIDATES

  
	 
	
   

  	
   

  	
   

  	
   

  
	 
	
   

  	
  6.1

  	
  Development
  and Commercialization Obligations

  
	 
	
   

  	
   

  	
  6.1.1

  	
  SCHERING’s
  obligations

  
	 
	
   

  	
   

  	
  6.1.2

  	
  EPIX’
  obligations

  
	 
	
   

  	
  6.2

  	
  Progress
  Reports

  
	 
	
   

  	
  6.3

  	
  Clinical Development by
  EPIX

  
	 
	
   

  	
  6.4

  	
  Record Keeping

  
	 
	
   

  	
   

  	
   

  
	 
	
  7.

  	
  LICENSE GRANTS; ROYALTIES

  
	 
	
   

  	
   

  	
   

  	
   

  
	 
	
   

  	
  7.1

  	
  Research
  Licenses

  
	 
	
   

  	
   

  	
  7.1.1

  	
  License
  to SCHERING

  
	 
	
   

  	
   

  	
  7.1.2

  	
  License to EPIX

  
	 
	
   

  	
  7.2

  	
  Development
  and Commercialization Licenses

  
	 
	
   

  	
   

  	
  7.2.1

  	
  Licenses
  to SCHERING

  
	 
	
   

  	
   

  	
  7.2.2

  	
  Licenses to
  EPIX

  
	 
	
   

  	
   

  	
  7.2.3

  	
  License Term

  
	 
	
   

  	
  7.3

  	
  Payments of
  EPIX

  
	 
	
   

  	
   

  	
  7.3.1

  	
  Milestones

  
	 
	
   

  	
   

  	
  7.3.2

  	
  Royalties
  by EPIX

  
	 
	
   

  	
  7.4

  	
  Royalties
  by SCHERING; Buy-up Option Epix

  
	 
	
   

  	
   

  	
  7.4.1

  	
  Royalty Rates

  
	 
	
   

  	
   

  	
  7.4.2

  	
  Buy-up Option Epix

  
	 
	
   

  	
   

  	
  7.4.3

  	
  Payments of EPIX
  under Buy-up Option

  
	 
	
   

  	
   

  	
  7.4.4

  	
  Sublicense
  Income

  
	 
	
   

  	
  7.5

  	
  General License Conditions

  
	 
	
   

  	
   

  	
  7.5.1

  	
  Payment Dates and Reports

  
	 
	
   

  	
   

  	
  7.5.2

  	
  Payments; Currency
  Conversion

  
	 
	
   

  	
   

  	
  7.5.3

  	
  Records; Audit Rights;
  Disputes

  
	 
	
   

  	
   

  	
  7.5.4

  	
  Taxes

  
	 
	
   

  	
   

  	
  7.5.5

  	
  Retained Rights

  
	
   

  	
   

  
	
  8.

  	
  TERMINATION

  
	
   

  	
   

  
	
   

  	
  8.1

  	
  Term

  
	
   

  	
  8.2

  	
  Termination By Either Party

  
	
   

  	
   

  	
  8.2.1

  	
  Termination
  for Breach

  
	
   

  	
   

  	
  8.2.2

  	
  Termination for Insolvency

  
	
   

  	
   

  	
  8.2.3

  	
  Termination for Convenience

  
	
   

  	
  8.3

  	
  Consequences of Termination

  
	
   

  	
  8.4

  	
  Surviving
  Provisions

  
	
   

  	
   

  	
   

  
	
  9.

  	
  INTELLECTUAL PROPERTY
  RIGHTS

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  9.1

  	
  Disclosure
  of Inventions

  
						



 


ii

















 


	
   

  	
  9.2

  	
  Ownership

  
	
   

  	
   

  	
  9.2.1

  	
  EPIX Background Technology

  
	
   

  	
   

  	
  9.2.2

  	
  SCHERING Background
  Technology

  
	
   

  	
   

  	
  9.2.3

  	
  Joint
  Technology

  
	
   

  	
  9.3

  	
  Patent
  Coordinators

  
	
   

  	
  9.4

  	
  Patent Filing,
  Prosecution and Maintenance

  
	
   

  	
   

  	
  9.4.1

  	
  Patent Filing,
  Prosecution and Maintenance of Joint Patent Rights

  
	
   

  	
   

  	
  9.4.2

  	
  Patent Filing,
  Prosecution and Maintenance by EPIX

  
	
   

  	
   

  	
  9.4.3

  	
  Patent Filing,
  Prosecution and Maintenance by SCHERING

  
	
   

  	
  9.5

  	
  Infringement of Patent
  Rights

  
	
   

  	
   

  	
  9.5.1

  	
  Infringement of
  Joint Patent Rights

  
	
   

  	
   

  	
  9.5.2

  	
  Infringement of EPIX
  Patent Rights

  
	
   

  	
   

  	
  9.5.3

  	
  Infringement of
  SCHERING Patent Rights

  
	
   

  	
   

  	
  9.5.4

  	
  Notice
  of Infringement

  
	
   

  	
   

  	
  9.5.5

  	
  Infringement
  of Know-How

  
	
   

  	
  9.6

  	
  Cooperation

  
	
   

  	
  9.7

  	
  Patent Management

  
	
   

  	
   

  	
   

  
	
  10.

  	
  CONFIDENTIALITY

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  10.1

  	
  Nondisclosure Obligations

  
	
   

  	
   

  	
  10.1.1

  	
  General

  
	
   

  	
   

  	
  10.1.2

  	
  Limitations

  
	
   

  	
   

  	
  10.1.3

  	
  Terms
  of this Agreement

  
	
   

  	
  10.2

  	
  Injunctive
  Relief

  
	
   

  	
   

  	
   

  
	
  11.

  	
  REPRESENTATIONS AND WARRANTIES

  
	
   

  	
   

  
	
   

  	
  11.1

  	
  Representations and
  Warranties

  
	
   

  	
  11.2

  	
  Organization

  
	
   

  	
  11.3

  	
  Authorization

  
	
   

  	
  11.4

  	
  No Inconsistent Obligation

  
	
   

  	
  11.5

  	
  Warranty
  Disclaimer

  
	
   

  	
   

  	
   

  
	
  12.

  	
  INDEMNITY

  
	
   

  	
   

  
	
   

  	
  12.1

  	
  Claim

  
	
   

  	
  12.2

  	
  SCHERING
  Indemnity Obligations

  
	
   

  	
  12.3

  	
  EPIX Indemnity Obligations

  
	
   

  	
  12.4

  	
  Procedure

  
	
   

  	
  12.5

  	
  Limited
  Liability

  
	
   

  	
   

  	
   

  
	
  13.

  	
  MISCELLANEOUS

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  13.1

  	
  Force Majeure

  
	
   

  	
  13.2

  	
  Assignment

  
	
   

  	
  13.3

  	
  Severability

  
	
   

  	
  13.4 

  	
  Notices

  
	
   

  	
  13.5

  	
  Applicable Law

  



 


iii

















 


	
   

  	
  13.6

  	
  General Dispute Resolution

  
	
   

  	
   

  	
  13.6.1

  	
  Negotiation

  
	
   

  	
   

  	
  13.6.2

  	
  Arbitration

  
	
   

  	
  13.7

  	
  Public
  Announcements

  
	
   

  	
  13.8

  	
  Entire Agreement; Amendment

  
	
   

  	
  13.9

  	
  Headings

  
	
   

  	
  13.10

  	
  Agreement Not to
  Solicit Employees

  
	
   

  	
  13.11

  	
  Exports

  
	
   

  	
  13.12

  	
  Waiver

  
	
   

  	
  13.13

  	
  Counterparts

  
	
   

  	
  13.14

  	
  Independent
  Contractors; Negation of Partnership

  
	
   

  	
  13.15

  	
  Ambiguities

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  Exhibit 1.13

  	
   

  	
  EPIX Patent Rights

  
	
   

  	
  Exhibit 1.15

  	
   

  	
  Products in Development or Commercialized

  
	
   

  	
  Exhibit 1.49

  	
   

  	
  SCHERING Patent Rights

  
	
   

  	
  Exhibit 2.4A

  	
   

  	
  Criteria for Lead Compounds

  
	
   

  	
  Exhibit 2.4B

  	
   

  	
  Criteria for Development Candidates

  
	
   

  	
  Exhibit 3.2A

  	
   

  	
  Copy of Loan Agreement

  
	
   

  	
  Exhibit 3.2B

  	
   

  	
  Copy of Security
  Agreement

  



 


iv

















 


COLLABORATIVE RESEARCH AGREEMENT


 


This COLLABORATIVE RESEARCH AGREEMENT (this
“Agreement”) is entered into as of May 26, 2003 (the “Effective Date”), by and
between Epix Medical, Inc., a Delaware corporation having its principal place
of business at 71 Rogers Street, Cambridge, MA 02142-1118 USA (“EPIX”), and
Schering Aktiengesellschaft, a German corporation having its principal place of
business at 13342, Berlin, Germany (“SCHERING”).  Each of SCHERING, EPIX and their respective Affiliates is
sometimes referred to individually herein as a “Party” and collectively as the
“Parties”.


 


WHEREAS, EPIX has
expertise and proprietary technology related to the discovery, development and
commercialization of products for use in magnetic resonance imaging;


 


WHEREAS, SCHERING has expertise and proprietary
technology related to the discovery, development and commercialization of
products for use in magnetic resonance imaging;


 


WHEREAS, EPIX and
SCHERING desire to bring their collective expertise, proprietary technology and
other resources together in a collaborative effort to discover new technology
and products for use in magnetic resonance imaging; and


 


WHEREAS, EPIX and SCHERING
further desire to provide for a series of rights and obligations pertaining to
the commercialization of new products arising from their collaborative efforts
as set forth herein.


 


NOW, THEREFORE, in
consideration of the mutual covenants contained herein, and for other good and
valuable consideration, the Parties hereto, intending to be legally bound,
hereby agree as follows:


 


1.                                       DEFINITIONS


 


Whenever used in this
Agreement with an initial capital letter, the terms defined in this
Section 1 shall have the meanings specified.


 


1.1                                 “Affiliate”
means any corporation, firm, partnership or other entity which directly or
indirectly controls or is controlled by or is under common control with a Party
to this Agreement. For purposes of this definition, “control” means ownership,
directly or through one or more Affiliates, of fifty percent (50%) or more of
the shares of stock entitled to vote for the election of directors, in the case
of a corporation, or fifty percent (50%) or more of the equity interests in the
case of any other type of legal entity, status as a general partner in any
partnership, or any other arrangement whereby a Party controls or has the right
to control the Board of Directors or equivalent governing body of a corporation
or other entity.


 


1.2                                 “Audit
Disagreement” has the meaning set forth in Section 7.5.3 (b).


 


1

















 


1.3                                 “Confidential
Information” means (a) all tangible embodiments of Technology
produced or discovered by either Party or jointly by the Parties under the
Research Program, the prosecution files pertaining to any Joint Patent Rights
and all information concerning the terms of this Agreement and (b) with respect
to a Party (the “Receiving Party”), all information, Technology and Proprietary
Materials which is disclosed by the other Party (the “Disclosing Party”) to the
Receiving Party hereunder or to any of its employees, consultants, Affiliates,
licensees or Sublicensees, except to the extent that the information described
in this Section 1.3(b), (i) as of the date of disclosure is demonstrably known
to the Receiving Party or its Affiliates, as shown by written documentation,
other than by virtue of a prior confidential disclosure to such Party or its
Affiliates; (ii) as of the date of disclosure is in, or subsequently enters,
the public domain, through no fault or omission of the Receiving Party; (iii)
is obtained from a Third Party having a lawful right to make such disclosure
free from any obligation of confidentiality to the Disclosing Party; or (iv) is
independently developed by or for the Receiving Party without reference to or
reliance upon any Confidential Information of the Disclosing Party as
demonstrated by competent written records.


 


1.4                                 “Control”
or “Controlled” means (a) with respect to Know-How (other than
Proprietary Materials) and/or Patent Rights, the possession by a Party of the
ability to grant a license or sublicense of such Know-How and/or Patent Rights
as provided herein without violating the terms of any agreement or arrangement
between such Party and any Third Party and (b) with respect to Proprietary
Materials, the possession by a Party of the ability to supply such Proprietary
Materials to the other Party as provided herein without violating the terms of
any agreement or arrangement between such Party and any Third Party.


 


1.5                                 “Cost”
or “Costs”
shall mean expenses incurred by the Parties, determined in a reasonable manner
in accordance with GAAP in case of EPIX and IAS in case of SCHERING, and
consistent with each Party’s accounting practice.


 


1.6                                 “Cost of
Goods Sold”  shall mean the cost for
manufacturing the Licensed Product, using SCHERING’s standard accounting
procedures computed in accordance with IAS applied on a consistent basis. Such
cost shall include, but not be limited to, the fully burdened cost of all raw
materials, auxiliaries and other ingredients, labor and overhead, depreciation,
maintenance and repair, destroyed material, production variance, imputed
interest on safety stocks and capacity cost for dedicated equipment, for the
synthesis, formulation, filling, finishing, labeling, packaging, storing,
testing and quality control, and assurance activities, and shall also include
reasonable expenses for services and transportation charges and any royalties
paid to Third Parties in connection with the manufacturing process or materials
used. “Cost of Goods” shall not include general and
administrative expenses, sales and marketing costs or costs associated with
meeting the chemistry manufacturing and control requirements of the FDA or
other regulatory authorities.


 


1.7                                 “Designation
Notice” has the  meaning
set forth in Section 2.4.


 


1.8                                 “Development
Candidates” shall mean Lead Compounds in the Field that progress
successfully through the lead optimization process and that are designated
according to


 


2

















 


the criteria in Exhibit
2.4 as “Development Candidates” as well as any modifications thereof during any
development process thereafter.


 


1.9                                 “Development
Costs” shall mean all internal (direct and indirect) and Third
Party expenses incurred by EPIX in connection with the Research Program, or by
SCHERING following exercise of the SCHERING Option, determined in a reasonable
manner in accordance with GAAP.  Such
expenses include, but are not limited to (i) direct labor (salaries, wages,
incentive awards and employee benefits but excluding any employee benefits
associated with equity incentive plans); (ii) materials and supplies; (iii)
allocated Costs for building space directly dedicated to the development of the
Lead Compounds, Development Candidates and/or Licensed Products (including
rent, depreciation, amortization and maintenance) but excluding expenses
relating to unused capacity, development of other products, and amortization of
property, plant and equipment not directly related to development of Lead
Compounds, Development Candidates and/or Licensed Products; (iv) Third Party
contracts and consulting expenses incurred for services in connection with the development
of Lead Compounds, Development Candidates and/or Licensed Products; (v)
allocated Costs for information technology directly dedicated to the
development of the Lead Compounds, Development Candidates and/or Licensed
Products; and (vi) travel and entertainment, telephone, recruiting, training
(both internal and external), clinical trial insurance, software, personal
computer equipment and support Costs and freight and delivery expenses. Such
Costs shall not include General and Administrative Expenses or expenses
incurred from departments that are not directly engaged in the development of
the Lead Compounds, Development Candidates and/or Licensed Products including,
but not limited to, finance and procurement, corporate administration, legal
(both external and internal expenses), human resources, business development
and licensing, sales and marketing except for Costs of investor relations.


 


Development
activities for which Development Costs are incurred include but are not limited
to pre-clinical and clinical work (Phase I-IV trials (such Phase IV trials to
be intended to support approval of an NDA, MAA or a supplement or amendment
thereto, required as a condition of approval of an NDA, MAA or a supplement or
amendment thereto, or required to support continued approval of an NDA, MAA or
a supplement or amendment thereto), regulatory filings, Cost of compound for
pre-clinical and clinical work (Phase I-IV trials, as described above in this
sentence), and all Costs of Lead Compounds, Development Candidates and/or
Licensed Products related to regulatory filings in the Territory including CMC
Costs.


 


1.10                           “Effective
Date” has the meaning set forth in the introductory paragraph.


 


1.11                           “EPIX
Background Technology” means collectively all EPIX Patent Rights
and EPIX Know-How.


 


1.12                           “EPIX
Option” has the meaning set forth in Section 4.2.


 


1.13                           “EPIX
Patent Rights” means the Patent Rights, Controlled by EPIX and
having claims covering EPIX Know-How, which are already in existence prior to
the Effective Date, as identified on Exhibit 1.13 hereto or filed thereafter.


 


3

















 


1.14                           “EPIX
Know-How” means all Know-How useful in the Field that is: (a)
Controlled by EPIX immediately prior to the Effective Date, or (b) developed or
conceived by EPIX on or after the Effective Date in the conduct of activities
outside of the Research Program.


 


1.15                           “Field”
means the diagnosis or characterization of diseases or conditions in humans
through the use of magnetic resonance imaging; provided, however,
that the Field shall not include: (i) any products that are subject to a
license granted under the Thrombus Development Agreement entered into by and
between the Parties as of the Effective Date or the Strategic Collaboration
Agreement between EPIX and SCHERING dated June 9, 2000, or (ii) any products
already commercialized or in preclinical or clinical development prior to the
Effective Date as set forth on Exhibit 1.15 , 
or (iii) any product, compound or Technology being subject to a contract
or collaboration with a Third Party which is already in existence prior to the
Effective Date, or any extension or amendment thereof, except for those
contracts as to be determined by the RSC.


 


1.16                           “FDA”
means the United States Food and Drug Administration or any successor agency.


 


1.17                           “First
Commercial Sale” means the date of the first sale of a Licensed
Product in the ordinary course of business in any country by a Party or an
Affiliate or Sublicensee of such Party after all marketing, pricing and/or
reimbursement approvals of the competent health authority(ies) of such country
required for sale of such product in such country have been obtained.


 


1.18                           “Full Time
Equivalent”  or “FTE” means one (1) or more qualified
employee(s), contractor(s) or agent(s) of a Party who, collectively, spend time
and effort working on a specific project or task equivalent to the time and
effort of one (1) full-time employee for one (1) year.


 


1.19                           “General
and Administrative Expenses” shall mean all direct and indirect
expenses incurred by SCHERING and EPIX in connection with departmental units
that are not directly engaged in the research, development, manufacturing, or
sales and marketing of Joint Technology, Lead Compounds, Development Candidates
and Licensed Products.  General and
Administrative Expenses shall include, but not be limited to, charges falling
within the following, groups: finance, procurement, order entry, corporate
administration, legal (both external and internal expenses), human resources,
business development and licensing and investor relations.  “General and Administrative Expenses” shall
exclude the following groups of charges: clinical trial insurance Costs,
facilities and information technology. 
Such expenses shall be determined in accordance with GAAP, consistently
applied.


 


1.20                           “IND”  means
an Investigational New Drug application, as defined in the United States Food,
Drug and Cosmetic Act and applicable regulations promulgated thereunder, or the
equivalent in any other country.


 


1.21                           “Indemnitee”
has the meaning set forth in Section 12.4.


 


4

















 


1.22                           “Indemnitor”
has the meaning set forth in Section 12.4.


 


1.23                           “Joint
Know-How” means all Know-How that is: (a) developed or conceived
by EPIX and/or SCHERING after the Effective Date in the conduct of activities
within the Research Program, and/or (b) Controlled jointly by EPIX and
SCHERING.


 


1.24                           “Joint
Patent Rights” means Patent Rights Controlled by SCHERING and
EPIX and having claims covering Joint Know-How, which are filed after the
Effective Date.


 


1.25                           “Joint
Technology” means collectively all Joint Patent Rights and Joint
Know-How.


 


1.26                           “Know-How”
means and includes all present and future know-how, inventions, trade secrets,
copyrights, data, regulatory submissions and other intellectual property of any
kind, whether patentable or not, including Proprietary Materials.


 


1.27                           “Lead
Compounds” means compounds that will be the subject of research
optimization efforts in the Research Program and that are designated, as
provided in Section 2.4, to be “Lead Compounds.”


 


1.28                           “Licensed
Product(s)” means any product based upon, derived from or
incorporating a Development Candidate or Joint Technology licensed by either
SCHERING or EPIX under this Agreement.


 


1.29                           “License
Term” has the meaning set forth in Section 7.2.3 of this
Agreement.


 


1.30                           “Management
Team” means the organizational body for the Research Program as
set forth in Section 5.2.


 


1.31                           “MAA”
means an application for Regulatory Approval to sell a Product in the European
Union.


 


1.32                           “NDA”  means
a New Drug Application, as defined in the United States Food, Drug and Cosmetic
Act and applicable regulations promulgated thereunder.


 


1.33                           “Net Sales”
shall meanthe amount invoiced by the selling Party, its Affiliates or
sublicensees for sales of a Licensed Product to unaffiliated Third Parties less
the following deductions applicable to the Licensed Product for:


 


(i)                                     transportation
charges and insurance charges paid by the selling Party;


 


(ii)                                  sales
and excise taxes or customs duties paid by the selling Party or any other
governmental charges imposed upon the sale of the Licensed Product and paid by
the selling Party exclusive of taxes on the income of the selling Party;


 


5

















 


(iii)                               fees
paid to distributors, consignees or agents in connection with the sale of the
Licensed Product;


 


(iv)                              rebates
and premiums granted in connection with the sale of a Licensed Product;


 


(v)                                 credits
to customers on account of governmental requirements, price differences,
rejection, outdating, returns or recalls of the Licensed Product;


 


(vi)                              quantity
discounts, cash discounts or chargebacks granted in connection with the sale of
the Licensed Product;


 


(vii)                           provisions
for price reductions; and


 


(viii)                        selling
Party’s standard allowance as demonstrated to the other Party’s reasonable
satisfaction, and in no case in excess of [*****].


 


For the purpose of
calculating Net Sales, the Parties recognize that (a) the selling Party’s
customers may include persons in the chain of commerce who enter into
agreements with the selling Party as to price even though title to the Licensed
Product does not pass directly from the selling Party to such customers and
even though payment for such Licensed Product is not made by such customers
directly to the selling Party and (b) in such cases, chargebacks paid by the
selling Party to or through a Third Party (such as a wholesaler) can be
deducted by the selling Party from gross revenue in order to calculate Net
Sales. Any deductions above which involve a payment by the selling Party shall
be taken as a deduction against aggregate sales for the period in which the
payment or deduction is made.


 


In the event a Licensed
Product is sold in the form of a combination product containing one or more
active ingredients in addition to a Licensed Product, Net Sales for such
combination product will be adjusted by multiplying actual Net Sales of such
combination product by the fraction A / (A+B) where A is the invoice price of
the Licensed Product, if sold separately, and B is the invoice price of any
other active ingredient or ingredients in the combination, if sold
separately.  If, on a country-by-country
basis, the other active ingredient or ingredients in the combination are not
sold separately in that country, Net Sales shall be calculated by multiplying
actual Net Sales of such combination product by the fraction A / C where A is
the invoice price of the Licensed Product if sold separately, and C is the
invoice price of the combination product. 
If, on a country by country basis, neither the Licensed Product nor the
other active component or components of the combination product is sold
separately in said country, Net Sales shall be determined between the Parties in
good faith. 


 


1.34                           “Part or
Parts of the Agreement” means either all terms relating to the
Research Program or all terms relating to a license granted or optioned under
this Agreement, depending on which terms are involved.


 


6

















 


1.35                           “Other
Schering Patent(s)” means any patent filed by SCHERING after the
Effective Date which incorporates Technology arising out of research activities
at SCHERING outside the Field and outside the scope of this Collaboration.


 


1.36                           “Patent
Rights” means the rights and interests in and to issued patents
and pending patent applications (which for purposes of this Agreement shall be
deemed to include certificates of invention and applications for certificates
of invention and priority rights) in any country, including all provisional
applications, substitutions, continuations, continuations-in-part, divisionals,
and renewals, all letters patent granted thereon, and all reissues,
reexaminations and extensions thereof, Controlled by a Party.


 


1.37                           “Phase
III Clinical Trial” means a pivotal human clinical trial in any
country the results of which could be used to establish safety and efficacy of
a Product as a basis for a marketing approval application submitted to the FDA,
or that would otherwise satisfy requirements of U.S. Statute 21 CFR 312.21(c),
or its foreign equivalent.


 


1.38                           “Project
Team(s)” means the working group(s) conducting the work in the
various research projects under the Research Plan(s) and established in
accordance with Section 5.3.


 


1.39                           “Proprietary
Materials” means any tangible chemical, biological or physical
research materials that are furnished by or on behalf of one Party to the other
Party in connection with this Agreement, regardless of whether such materials
are specifically designated as proprietary by the transferring Party.


 


1.40                           “[*****]”
means the use of [*****] to a [*****] for the purpose of imaging in [*****] or
[*****] or for [*****].


 


1.41                           “Regulatory
Approval”  means any approval, product and establishment
license, registration or authorization of any national, federal, state or local
regulatory agency, department, bureau or other governmental entity necessary
for the manufacture, use, storage, importation, export, transport or sale by a
Party of a Licensed Product in a regulatory jurisdiction.


 


1.42                           “Research
Plan(s)” means the written plan(s) and description(s) of  each research project to be conducted under
this Agreement, as to be determined by the RSC.


 


1.43                           “Research
Program” means the collaborative research  program to be conducted pursuant to this
Agreement as reflected in the Research Plan(s), focusing initially in the
following three areas; (a) inflammation (including plaque) imaging with
magnetic resonance imaging contrast media (including gadofluorines), (b)
cardiac perfusion imaging, and (c) high-sensitivity magnetic resonance imaging
contrast media.


 


1.44                           “Research
Program Term” has the meaning set forth in Section 2.1.


 


7

















 


1.45                           “Research
Steering Committee” or  “RSC” means the committee of EPIX and
SCHERING representatives established pursuant to Section 5.1 hereof to
administer the affairs of the Collaboration.


 


1.46                           “SCHERING
Background Technology” means collectively all SCHERING Patent
Rights and SCHERING Know-How.


 


1.47                           “SCHERING
Know-How” means all Know-How useful in the Field that is: (a)
Controlled by SCHERING immediately prior to the Effective Date, or (b)
developed or conceived by SCHERING on or after the Effective Date in the
conduct of activities outside of the Research Program.


 


1.48                           “SCHERING
Option” has the meaning set forth in Section 4.1.


 


1.49                           “SCHERING
Patent Rights” means the Patent Rights, Controlled by SCHERING
and having claims covering SCHERING Know-How, which are already in existence
prior to the Effective Date, as identified on Exhibit 1.49 hereto or filed
thereafter.


 


1.50                           “Sublicense
Income” means all payments received by a Party from a
sublicensee in connection with the grant of a sublicense under a development
and a commercial license in accordance with Section 4.4  or Section 7.2, including without limitation,
royalties, up-fronts, technology access fees, milestones and fifty percent
(50%) of the premium over fair market value paid to such Party  in connection with  the issuance of securities of such Party where fair market value
is based on the number of securities issued multiplied by the average closing
price of the stock as quoted on the stock exchange (NASDAQ or Deutsche Boerse
XETRA, respectively), such average based on a twenty (20) business day period,
but excluding (a) payments made to support or fund research and development
activities and (c) payments made for other rights or tangible property to the
extent not in excess of the fair market value of such other rights or tangible
property.


 


1.51                           “Term”
has the meaning set forth in Section 8.1.


 


1.52                           “Territory”
means all countries of the world.


 


1.53                           “Third
Party” means any person or entity other than SCHERING and EPIX
and their respective Affiliates.


 


2.                                       RESEARCH
PROGRAM


 


2.1                                 Objectives of the Research Program; Term;
Exclusivity.  The
objectives of the Research Program shall be the discovery and optimization of
compounds that may become Licensed Products and Joint Technology that is useful
in the Field.  The Research Program
shall commence on the Effective Date and shall continue for a period of three
(3) years, with an option to extend the Program for two (2) additional years
upon mutual agreement of both Parties no


 


8

















 


later than ninety
(90) days prior to the expiration of the initial term (the “Research Program
Term”).  Neither Party shall perform any
research, in the Field during the Research Program Term outside of this collaboration.


 


2.2                                 Obligations of the Parties.


 


2.2.1                        Research Plan(s).  The work under the Research Program will be
organized into various research projects to be conducted in accordance with a
Research Plan, which may be amended from time-to-time during the Research
Program Term.  The initial Research Plan
will be determined at the first meeting of the RSC.  The Parties will execute each Research Plan in accordance with
the requirements set forth herein (for example, with the diligence specified in
Section 2.2.2). For each of the research projects one of the Parties shall be
designated by the Management Team as being primarily responsible for the
various tasks under the relevant Research Plan. Each Research Plan may be
modified upon proposal for such modification by the Project Team to the Management
Team, which shall discuss and decide about such modifications.


 


2.2.2                        Due Diligence; Commitment of FTE’s.  Each Party will use commercially reasonable
efforts to perform all aspects of its obligations under the relevant Research
Plan(s) consistent with the efforts it devotes to its other collaborations with
commercial entities, and in accordance with all applicable laws, ordinances,
rules, regulations, orders, licenses and other requirements now or hereafter in
effect.  Each Party shall devote  [*****] FTE’s exclusively to the performance
of its obligations under the Research Program. The Management Team shall
allocate the actual number of FTE’s for each research project.  [*****] [*****] months after the Effective
Date EPIX may start to reduce its number of FTE’s to a [*****].  After such reduction of FTE’s [*****] the
[*****].  The individuals whom each
Party commits to the performance of the Research Program shall have the
training and experience required to perform the tasks assigned to him or her by
each Party in a manner consistent with this standards set forth in this Section
2.2.2.  Each Party will maintain a list
of the individuals it commits to the performance of the Research Program and
shall share such list with the other Party solely to facilitate the performance
of the Research Program and to allow each Party to monitor the other Party’s
compliance with this Section.  The list
of individuals each Party shall commit to the performance of the Research Program
shall be determined and exchanged at the first meeting of the RSC.


 


2.2.3                        Information Exchange; Reports.  The Party responsible for a research project
shall keep the Management Team fully informed about the status of the  Research Plan for which it is responsible.  In addition, each Project Team shall submit
a written report, describing the progress of the work done by it under the
relevant Research Plan in reasonable detail, to the Research Steering Committee
(RSC) at least seven (7) days prior to each meeting of the RSC. The Parties expect
that the exchange of information and materials may involve on-site visits and
longer exchange visits by scientists of one Party to the facilities of the
other Party. Such visits will have defined purposes, include a reasonable
number of participants and be scheduled reasonably in advance.


 


9

















 


2.2.4                        Supply of Proprietary Materials.  From time-to-time during the Term of this
Agreement, a Party (the “Transferor”) may supply the other Party (the
“Recipient”) with its Proprietary Materials for use in the Research Program or
for any additional development activities agreed upon by the Parties.  In connection therewith, the Recipient
hereby agrees that: (a) it shall not use Proprietary Materials for any purpose
other than exercising any rights granted to it or reserved by it hereunder, (b)
it shall use the Proprietary Materials only in compliance with all applicable,
federal, state, and local laws and regulations, (c) it shall not transfer any
Proprietary Materials to any Third Party without the prior written consent of
the Transferor, except as expressly permitted hereby, (d) the Transferor shall
retain full ownership of all such Proprietary Materials and (e) upon the
expiration or termination of this Agreement, the Recipient shall at the
instruction of the Transferor either destroy or return any Proprietary
Materials which are not the subject of the grant of a continuing license
hereunder.


 


2.3                                 Contract Services and Goods.  The Research Program indicates the Parties’
currently anticipated needs for contracted services and goods.  The decision on contracting any goods and
services from Third Parties shall be made by the Management Team. SCHERING
shall be responsible for funding such contracted services and goods if needed
and as indicated in one of the Research Plan(s) on a case-by-case basis up to a
maximum of $[*****] for each full calendar year, such amount to be reduced
ratably for any partial year.  The cost
of any other contracted goods and services as are provided for in the Research
Plan(s) shall be shared equally by the Parties.  As is set forth in more detail in Section 2.2.2, the Parties
shall commit [*****] FTE’s each to the performance of the Research Program.  In the event EPIX in fact commits less than
[*****] FTE’s to the performance of the Research Program, then the funding for
contracted goods and services set forth herein shall be reduced ratably over
such period of time unless the RSC shall determine otherwise. With regard to
all contracts already executed prior to the Effective Date for which the
Parties may agree to include them in the Field and, therefore, this Agreement,
all payments due under those contracts for the calendar year 2003 shall be paid
pro rata under this Section 2.3 as of the Effective Date. It is understood
between the Parties that the inclusion of any such Third Party contract may
only be included in this Agreement upon the Third Party’s consent. [*****] the
Parties agree [*****] of [*****] does [*****], Epix and Schering [*****] of
[*****] contract as [*****] or [*****]


 


2.4                                 Discovery of Lead Compounds.  The initial work under the Research Program
will be focused on the discovery of compounds meeting criteria set forth in
Exhibit 2.4A.   Upon proposal of the
relevant Project Team the Management Team shall submit the most promising
compounds to the RSC for designation as “Lead Compounds” in accordance with the
criteria set forth in Exhibit 2.4 A. 
Lead Compounds will undergo additional lead optimization efforts in
order to meet the criteria identified on Exhibit 2.4 B. Upon proposal of the
relevant Project Team, the Management Team shall decide upon submission of a
Lead Compound to the RSC for designation as a Development Candidate. If it has
been submitted by the Management Team and the RSC has positively decided to
designate the Lead Compound as a Development Candidate, the RSC shall provide
written notice to SCHERING and EPIX with its decision (the “Designation
Notice”).  It is understood that the
SCHERING members on the RSC have the authority to render any decision hereunder
only after an internal review and approval process for


 


10

















 


any Lead Compound
or Development Candidate at SCHERING. Such review process shall be initiated by
a SCHERING RSC or Management Team member as soon as possible and shall in any
case be finished within ninety (90) days after submission of a Lead Compound or
Development Candidate to the RSC by the Management Team.


 


3.                                       RESEARCH FUNDING


 


3.1                                 Payments by SCHERING.  In 
consideration of the performance by EPIX of the Research Program,
SCHERING shall make  payments to EPIX in
the aggregate amount of $[*****] (= $[*****] per FTE) for each twelve (12)
month period during the Research Program Term. 
Such annual payment shall be made in equal quarterly installments with
the first such payment being due and payable within ten (10) business days of
the Effective Date and with subsequent payments becoming due and payable every
three (3) months thereafter during the Research Program Term.  The annual payment shall be reduced
accordingly if and whenever EPIX reduces its committed FTEs in accordance with
Section 2.2.2.


 


3.2                                 Loan by SCHERING to EPIX.  SCHERING shall provide a loan of
up to $15,000,000 to EPIX in accordance with the terms and conditions set forth
in the Loan Agreement and the Security Agreement, copies of which are attached
hereto as Exhibit 3.2A and Exhibit 3.2B respectively.


 


4.                                       OPTION RIGHTS FOR DEVELOPMENT
CANDIDATES AND JOINT TECHNOLOGY


 


4.1                                 SCHERING License Option.


 


4.1.1                        Option Grant.  EPIX hereby grants to SCHERING the exclusive
right and option (the “SCHERING Option”) to obtain an exclusive license under
the terms set forth in Section 7 to develop and commercialize products based
upon, derived from or incorporating a Development Candidate with the right to
sublicense (the “SCHERING Option”).


 


4.1.2                        Exercise of SCHERING Option.  Upon the delivery by the RSC to SCHERING and
EPIX of a Designation Notice, SCHERING will have a period of [*****] [*****] to
determine whether to exercise the SCHERING Option with respect to the
Development Candidate identified in such notice.  SCHERING shall notify EPIX of its decision within such [*****]
period.  If no notice is provided to
EPIX within such [*****] period, the SCHERING Option for such Development
Candidate shall expire.


 


4.2                                 Failure to Exercise; EPIX License Option.  For all Development Candidates for which
SCHERING fails to exercise the SCHERING Option, SCHERING hereby grants to EPIX
the exclusive right and option (the “EPIX Option”) to obtain an exclusive
license under the terms set forth in Section 7 and to further develop and
commercialize products based upon, derived from or incorporating such
Development Candidate, with the right to sublicense.  Each EPIX


 


11

















 


Option shall
commence upon the expiration of the corresponding SCHERING Option and shall be
exercised within [*****] upon notification to SCHERING. If no notice is
provided by EPIX within such [*****] period, the EPIX Option for such
Development Candidate shall expire.


 


4.3                                 Failure to Exercise the Option by both Parties.  In case that neither SCHERING nor EPIX
exercise their respective option for the relevant Development Candidate during
the period set forth in Section 4.1 or Section 4.2 as applicable, both the EPIX
Option and the SCHERING Option shall again become operative and either Party
may thereafter exercise its option by written notice to the other Party.  Options shall then be exercisable on a
first-come, first-served basis.


 


4.4                                 Joint Technology Option.  Each Party hereby grants to the other the
right and option  to obtain an
exclusive, worldwide, royalty-bearing license, with the right to grant
sublicenses, under such Party’s interest in the Joint Technology, to the extent
required to permit such other Party to develop, make, have made, use, sell,
promote, have sold, and import a product based upon, derived from or
incorporating Joint Technology for use in [*****] the [*****].  The Joint Technology option shall not apply
to Development Candidates.  This option
shall commence upon the expiration of the Research Program and shall continue
in full force and effect until the [*****] anniversary of the termination of
the Research Program.  The Joint Technology
option shall be exercisable by written notice from one Party to the other Party
and on a first-come, first-served basis. For all exclusive licenses optioned
under this Section 4.4 the royalty rate of Section 7.2.1 (b) (royalties for
[*****] shall apply as well as Section 7.2.3 and Section 7.5. Notwithstanding
any rights which the Parties may have at law or otherwise as joint owners of
the Joint Technology, the Parties hereby agree that neither of them will
practice any Joint Technology, except as provided in this Section 4.4 or in
their performance hereunder, without the express written consent of the other
Party during the Term and for a period of [*****] years thereafter.


 


5.                                       ADMINISTRATION OF THE COLLABORATION


 


5.1                                 Establishment and Function of RSC.  EPIX and SCHERING hereby establish a
“Research Steering Committee” (or “RSC”) to oversee the Research Program.  The RSC shall have the responsibilities as
set forth in Section 5.1.4.


 


5.1.1                        Membership.


 


(a)                                  The
RSC shall be comprised of two (2) named representatives of SCHERING and two (2)
named representatives of EPIX.  The RSC
representatives shall be appointed as soon as possible after the Effective Date
and shall meet as needed but not less than twice annually.  Such meetings shall be at times and places
or in such form as the members of the RSC shall agree, and may take place by
conference call or videoconference. 
Each Party shall have the right to have other employees of the same
Party (or consultants to such Party, with the advance permission of the other
Party) present at and participating in any RSC meeting provided that the names,
titles, and subject matter to be addressed by such additional attendees are


 


12

















 


submitted in
writing to the other Party at least three (3) business days in advance of the
meeting, and that neither Party has more than five (5) attendees at a meeting
without the advance permission of the other Party.


 


(b)                                 A
Party may change its representative to the RSC at any time. Members of the RSC
may be represented at any meeting by an authorized designee. In making any
approval, determination or taking any other action delegated to the RSC,
SCHERING and EPIX shall each have one vote on the RSC, regardless of how many
representatives each Party may have in attendance at any RSC meeting.


 


5.1.2                        Chair.  The RSC shall initially be chaired by the
EPIX representative (the “Chair”) and thereafter the Chair shall alternate from
meeting to meeting between the representative of SCHERING and the representative
of EPIX.


 


5.1.3                        Minutes.  The RSC shall keep accurate minutes of its
deliberations, which record all proposed decisions and all material actions
recommended or taken.  The Chair shall
be responsible for the preparation of draft minutes.  Draft minutes shall be sent to the other member of the RSC within
ten (10) working days after each meeting. 
The draft minutes shall be edited by the Chair based on comments from
the other member of the RSC to be provided within ten (10) working days and
shall be distributed to the other member by the Chair within thirty (30)
working days after the meeting, and in any case no later than one (1) week
prior to the next meeting.  All minutes
of the RSC shall at all times be available to both Parties.


 


5.1.4                        Responsibilities of the RSC.  The RSC shall be responsible for making
strategic decisions relating to the overall Research Program, including without
limitation, the following matters:


 


(a)                                  determination
of a Research Plan and any amendments thereto or changes thereof;


 


(b)                                 monitoring
the progress of the Research Program based upon information from the Management
Team;


 


(c)                                  approving
resource allocation and approving priorities within the Research Program with
regard to each Research Plan;


 


(d)                                 determination
of potential Lead Compounds;


 


(e)                                  determination
of potential Development Candidates; and


 


(f)                                    dispute
resolution for disputes among Management Team.


 


5.1.5                        RSC Dispute Resolution.  In the event that the RSC shall not be able
to reach a decision or take an action on any matter that is reserved to the RSC
hereunder, then such RSC decisions shall first be referred for resolution to
the Chief Executive Officer  of EPIX and the Head of Corporate Research
of SCHERING for attempted resolution by good faith negotiation.  Such good faith negotiation may include the
appointment by either Party of an


 


13

















 


unaffiliated
expert chosen on the basis of such person’s experience and expertise in the
particular type of issue that is unresolved, in order to advise such officers
on the matter.  If such officers are
unable to resolve the matter within ninety (90) days, then SCHERING shall have
authority to make the decision.


 


5.2                                 Establishment and Function of
Management Team. 
EPIX and SCHERING hereby establish a “Management Team” to plan and
administer the execution of the various projects composing the Research Program
and reflected by the Research Plan(s). 
The Management Team shall have the responsibilities as set forth in
Section 5.2.4.


 


5.2.1                        Membership.


 


(a)                                  The
Management Team shall be comprised of two (2) named representatives of SCHERING
and two (2) named representatives of EPIX. 
Each such representative shall be appointed as soon as possible after
the Effective Date and shall meet as needed but not less than four times
annually.  Such meetings shall be at
times and places or in such form as the members of the Management Team shall
agree, and may take place by conference call or videoconference.  Each Party shall have the right to have
other employees of the same Party (or consultants to such Party, with the
advance permission of the other Party) present at and participating in any
Management Team meeting provided that the names, titles, and subject matter to
be addressed by such additional attendees are submitted in writing to the other
Party at least three (3) business days in advance of the meeting, and that
neither Party has more than three (3) attendees at a meeting without the
advance permission of the other Party.


 


(b)                                 A
Party may change its representatives to the Management Team at any time.  Members of the Management Team may be
represented at any meeting by an authorized designee.  In making any approval, determination or taking any other action
delegated to the Management Team, SCHERING and EPIX shall each have one vote on
the Management Team, regardless of how many representatives each Party may have
in attendance at any Management Team meeting.


 


5.2.2                        Chair. 
The  Team shall initially be
chaired by one of the EPIX representatives (the “Chair”) and thereafter the
Chair shall alternate from meeting to meeting between one of the
representatives of SCHERING and one of the representatives of EPIX.


 


5.2.3                        Minutes. 
The Management Team shall keep accurate minutes of its deliberations,
which record all proposed decisions and all actions recommended or taken.  The Chair shall be responsible for the
preparation of draft minutes.  Draft
minutes shall be sent to the other member of the Management Team within ten
(10) working days after each meeting. 
The draft minutes shall be edited by the Chair based on comments from
the other member of the Management Team to be provided within ten (10) working
days and shall be distributed to the other member by the Chair within thirty
(30) days after the meeting, but in no case later than one (1) week prior to
the next meeting of the Management Team. All records of the Management Team
shall at all times be available to both Parties.


 


14

















 


5.2.4                        Responsibilities of Management Team.  The Management Team shall be responsible for
making decisions that are relevant to the individual research projects within
the Research Program, including without limitation, the following matters:


 


(a)                                  allocating
FTE’s and resources to the research projects (to be approved by RSC)


 


(b)                                 choosing
project management tools;


 


(c)                                  monitoring
the progress of each research project and providing information to the RSC


 


(d)                                 selection
of contract service providers


 


(e)                                  proposing
potential Lead Compounds to RSC;


 


(f)                                    proposing
potential Development Candidates to RSC.


 


5.2.5                        Management Team Dispute Resolution.  In the event that the Management Team shall
not be able to reach a decision or take an action on any matter that is
reserved to the Management Team hereunder, then such dispute shall first be
referred for resolution to the RSC. If the RSC can not agree on the solution
for the dispute, Section 5.1.5 shall apply accordingly.


 


5.3                                 Establishment of Project Team(s).  Upon consultation with the Party primarily
responsible for the relevant research project, the Management Team shall
determine and nominate a Project Team consisting of all FTE’s working on that
research project.


 


6.                                       DEVELOPMENT AND COMMERCIALIZATION
OF DEVELOPMENT CANDIDATES


 


6.1                                   Development and Commercialization
Obligations.


 


6.1.1                        SCHERING’s obligations.  SCHERING shall use diligent efforts to
undertake the development and commercialization of each Licensed Product
licensed hereunder in the Field, using the level of resources and effort which
are consistent with those which it would apply to a product of comparable
potential resulting from its own research programs.


 


6.1.2                        EPIX’ obligations.  EPIX shall use diligent efforts to undertake
the development and commercialization of each Licensed Product licensed
hereunder in the Field, using the level of resources and effort which are
consistent with those which it would apply to a product of comparable potential
resulting from its own research programs.


 


6.2                                 Progress Reports.    The developing Party shall keep the other
Party regularly informed on all development activities for a Licensed Product,
at least by annual up-date reports.


 


15

















 


6.3                                 Clinical Development by EPIX.  In the event that  SCHERING desires for EPIX to perform additional development work
on a licensed Development Candidate, including without limitation, clinical
trials, then EPIX and SCHERING shall agree on a development plan to advance
such Development Candidate through to completion of a proof-of-concept clinical
trial.  Such development plan will
include a protocol for such proof-of-concept clinical trial and estimated
Development Cost for such proof-of-concept clinical trial.  SCHERING shall deliver the development plan
to EPIX upon its completion.  EPIX will
then have a period of thirty (30) days to determine, in its sole discretion,
whether to accept the obligation to undertake the additional work described in
the development plan.  In the event that
EPIX agrees to perform such work, EPIX will so notify SCHERING in writing and
EPIX will perform the work, in accordance with the diligence standards provided
hereunder.  Such additional work shall
not be deemed to be part of the Research Program  and EPIX shall not be permitted to count the efforts it makes
under such development plan as work performed under the Research Program for
purposes of determining whether it has met the requirement that it commit
[*****] to the work under the Research Program.  SCHERING shall reimburse, on a monthly basis, one hundred percent
(100%) of all Development Costs incurred by EPIX in performing such development
work.  EPIX shall invoice SCHERING for
such amounts at the end of each calendar month and shall provide sufficient
detail of the costs and expenses incurred.


 


6.4                                 Record Keeping.  EPIX and SCHERING shall each maintain
records in sufficient detail and in accordance with commonly accepted industry
standards which will document in a manner appropriate for purposes of
supporting the filing of potential patent applications, all work done and
results achieved in the performance of the Research Program (including all data
in the form required under any applicable governmental regulations). Subject to
Article 10 hereof, EPIX and SCHERING shall each provide the other the right to
inspect and copy such records to the extent reasonably required for the
performance of its obligations under this Agreement and shall not use such
records or information except to the extent otherwise permitted by this
Agreement.


 


7.                                       LICENSE GRANTS; ROYALTIES


 


7.1                                 Research Licenses.


 


7.1.1                        License to SCHERING.   EPIX hereby grants to SCHERING and its
Affiliates a fully paid-up, non-exclusive, royalty-free, worldwide license in
the Field, without the right to grant sublicenses, under EPIX Background
Technology, for the sole purpose of conducting the activities required in the
performance of its obligations hereunder as part of the Research Program,
during the Research Program Term.


 


7.1.2                        License to EPIX.  SCHERING hereby grants to EPIX and its
Affiliates a paid-up, non-exclusive, royalty-free, worldwide license in the
Field, without the right to grant sublicenses under SCHERING Background
Technology for the sole purpose of conducting the activities required in the
performance of its obligations hereunder as part of the Research Program,
during the Research Program Term.


 


16

















 


7.2                                 Development and Commercialization
Licenses.


 


7.2.1                        Licenses to SCHERING


 


(a)                                  Subject
to SCHERING’s exercise of the SCHERING Option, EPIX hereby grants to SCHERING
an exclusive, worldwide, royalty-bearing license, with the right to grant
sublicenses under the EPIX Background Technology and EPIX’ interest in the
Joint Technology to the extent required to permit SCHERING  to develop, make, have made, use, promote,
sell, have sold and import Licensed Products, for use in the Field, in the
Territory during the License Term.


 


(b)                                 EPIX
hereby grants to SCHERING an exclusive, worldwide, royalty-bearing license,
with the right to grant sublicenses under EPIX’ interest in the Joint
Technology to permit SCHERING to develop, make, have made, use, promote, sell,
have sold and import products for use in the  [*****]
during the License Term.  Anything to
the contrary herein notwithstanding, products which are developed, made, used,
promoted, sold or imported under this license shall be “Licensed Products” for
all purposes under this Agreement except that the following Sections shall not
apply to such products: Section 6.1.1, 6.2, 7.2.3(b) and Section 7.4. SCHERING
shall pay a royalty on products under this Section equal to [*****] [*****] of
Net Sales. SCHERING shall inform EPIX about the First Commercial Sale of any
product under this license. For the sake of clarity the Parties agree that any
royalty obligation under this Section expires upon the expiration of the last
to expire of the relevant Patent Rights in the country covering the product.


 


7.2.2                        Licenses to EPIX


 


(a)                                  Subject
to EPIX’s exercise of the EPIX Option, SCHERING hereby grants to EPIX an
exclusive, worldwide, royalty-bearing license, with the right to grant
sublicenses under the SCHERING Background Technology and SCHERING’s interest in
the Joint Technology to the extent required to permit EPIX to develop, make,
have made, use, sell, promote, have sold and import Licensed Products, for use
in the Field, in the Territory during the License Term.


 


(b)                                 SCHERING
hereby grants to EPIX a non-exclusive, worldwide, royalty-free license, without
the right to grant sublicenses under Other Schering Patent(s) to the extent
necessary to permit EPIX to develop, make, have made, use, promote, sell, have
sold and import Licensed Products in the Field.


 


7.2.3                        License Term.  The term of any license granted pursuant to
Section 7.2 or Section 4.4 with respect to any Licensed Product, shall commence
(i) in case of a license granted under Section 7.2.1 (a) or 7.2.2 (a) upon the
date the option giving rise to such license is exercised in accordance with
this Agreement, or (ii) in case of a license granted under Section 7.2.1 (b),
7.2.2 (b) or 4.4 upon the existence of the relevant Joint Technology, or Other
Schering Patent(s) and shall continue on a country-by-country and
product-by-product basis until the longer of: (a) the expiration of the last to
expire of the relevant Patent Rights in the country


 


17

















 


covering the
Licensed Product and (b) the expiration of [*****] from the First Commercial
Sale in such country of such Licensed Product (the “License Term”).  Upon the expiration of the License Term for
each  Licensed Product, such license
shall convert automatically to a paid up, royalty-free license to develop,
manufacture, use, sale or import such Licensed Product.  The Parties hereby acknowledge that during
the License Term royalties may be payable hereunder for a Licensed Product that
is not covered by any claim in Patent Rights subject to a license granted
hereunder.  Under such circumstances,
royalties shall be payable as set forth herein, but at a reduced rate equal to
fifty percent (50 %) of the royalty rate which would otherwise be payable
hereunder, if the manufacture, use, sale or importation of such Licensed
Product were covered by a claim in Patent Rights subject to a license granted
hereunder.  Such reduced royalties shall
be in consideration of: (i) the commercial advantage and background information
gained from the Research Program, (ii) the contribution of the unpatented
Technology to the successful development of the Licensed Product and (iii) the
exclusivity of the Collaboration.


 


7.3                                 Payments of EPIX


 


7.3.1                        Milestones.  EPIX shall make the following one-time
milestone payments to SCHERING for each EPIX Licensed Product.  Such payments shall be due and payable
within thirty (30) days following the achievement of the corresponding
milestone event.


 


	
  Milestone Event

  	
   

  	
  Milestone
  Payment

  Amount

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  [*****]

  	
   

  	
  $

  	
  [*****]

  	
   

  
	
  [*****]

  	
   

  	
  $

  	
  [*****]

  	
   

  
	
  [*****]

  	
   

  	
  $

  	
  [*****]

  	
   

  
	
  [*****]

  	
   

  	
  $

  	
  [*****]

  	
   

  



 


7.3.2                        Royalties by EPIX.


 


(a)                                  EPIX
shall pay SCHERING a royalty based on total annual Net Sales of each Licensed
Product sold by EPIX and/or its Affiliates during the License Term, at the
following rates:


 




	
  On Annual Net Sales of a

  Licensed Product between:

  	
   

  	
  Royalty
  Rate (%)

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  Above
  $ [*****]$ [*****]

  	
   

  	
  [*****]

  	
  %

  
	
   

  	
   

  	
   

  	
   

  
	
  Above
  $ [*****]

  	
   

  	
  [*****]

  	
  %

  






 


(b)                                 EPIX
shall pay SCHERING [*****] of any and all Sublicense Income within thirty (30)
days of receipt by EPIX.


 


18

















 


7.4                                 Royalties
by SCHERING; Buy-up Option EPIX.


 


7.4.1                        Royalty Rates.  SCHERING shall pay EPIX a royalty based on
total annual Net Sales of each  Licensed
Product sold by SCHERING and/or its Affiliates during the License Term at the
following rates:


 




	
  On Annual Net Sales of a

  Licensed Product between:

  	
   

  	
  Royalty
  Rate (%)

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  Above
  $[*****] and up to $[*****]

  	
   

  	
  [*****]

  	
  %

  
	
   

  	
   

  	
   

  	
   

  
	
  Above
  $[*****]

  	
   

  	
  [*****]

  	
  %

  






 


7.4.2                        Buy-up Option EPIX.  Notwithstanding the foregoing, EPIX shall
have the option of increasing the above royalty rates payable with respect to
each Licensed Product sold by SCHERING by reimbursing SCHERING for a percentage
of all the Development Costs for such Licensed Product incurred by SCHERING as
follows.  For every [*****] of the total
Development Costs incurred by SCHERING after the date SCHERING exercises the
SCHERING Option for a particular Licensed Product that EPIX reimburses SCHERING
for, the royalty rate otherwise payable under the table above will be increased
by [*****] [*****].  This option is
limited such that EPIX cannot reimburse SCHERING for more than [*****] of such
Development Costs for any Licensed Product and so the maximum royalty rates
payable for any SCHERING Licensed Product are [*****] and [*****]; provided,
however, if the [*****] for any Licensed Product is [*****] than [*****] of the
[*****] of [*****], then [*****] this [*****] hereunder.  EPIX must exercise this option with respect
to a  Licensed Product by providing
written notice to SCHERING within [*****] months after the day on which
SCHERING exercises the SCHERING Option relating to such Licensed Product.  If EPIX fails to provide notice within such
[*****] month period, this option shall expire with respect to such Licensed
Product and shall be of no further force or effect.


 


7.4.3                        Payments of EPIX under Buy-up Option.  Within one (1) month from the end of the
calendar quarter in which EPIX has exercised its buy-up option and on a
quarterly basis thereafter, EPIX shall pay its share of the Development Costs
incurred by SCHERING during the relevant calendar quarter, except that the
first such payment shall include reimbursement based on total Development Costs
incurred by SCHERING from the date it exercised the SCHERING Option.  The Development Costs incurred by SCHERING
during each calendar quarter shall be converted from EURO into United States
Dollars by the EURO Foreign Exchange Reference Rate published by the European
Central Bank in Frankfurt/Main on the last day of the applicable calendar
quarter. The
corresponding calculation will be provided by SCHERING to EPIX within fifteen
(15) business days  from the end of the
respective calendar quarter.


 


7.4.4                        Sublicense Income.  SCHERING shall pay EPIX [*****] of any and
all


 


19

















 


Sublicense Income within thirty (30) days of receipt by SCHERING.


 


7.5                                 General License Conditions.


 


7.5.1                        Payment Dates and Reports.  All royalty payments on Net Sales shall be
paid within sixty (60) days after the end of each calendar quarter in which
such Net Sales are made.  Such payments
shall be accompanied by a report for the applicable calendar quarter showing
the Net Sales of each Licensed Product sold,   the applicable royalty rate for such Licensed Product, and a
calculation of the amount of royalty due.


 


7.5.2                        Payments; Currency Conversion.


 


(a)                                   Payments.  Payments by either Party to the other Party
under this Agreement shall be made in United States dollars by wire transfer of
immediately available funds to an account at a commercial bank designated by
the receiving Party at least ten (10) Business Days before such payment is due.


 


(b)                                  Royalty
Payments within SCHERING. 
The calculation of royalty payments within SCHERING is based on Euro.
Therefore, where payments are based on Net Sales in countries other than the
member states of the European Monetary Union, the amount of such Net Sales
expressed in the currency of each country shall be converted into Euro at the
Euro Foreign Exchange Reference Rates published by the European Central Bank in
Frankfurt / Main, Germany on the last Business Day of the applicable calendar
quarter. The resulting Euro amount will be converted into United States dollars
again at the Euro Foreign Exchange Reference Rates published by the European
Central Bank in Frankfurt / Main, Germany on the last Business Day of the
applicable calendar quarter. These Euro Foreign Exchange Reference Rates are,
as of the effective date, published on Reuters screen <ECB37>.  If no Euro Foreign Exchange Reference Rate
is determined for the relevant currency the parties shall agree upon another
reference rate.


 


(c)                                   Royalty
Payments within EPIX. 
The calculation of royalty payments within EPIX is based on United
States dollars. Therefore, where payments are based on Net Sales in countries
other than the United States, the amount of such Net Sales expressed in the
currency of each country shall be converted into United States dollars at the
Euro Foreign Exchange Reference Rates published by the European Central Bank in
Frankfurt / Main, Germany on the last Business Day of the applicable calendar
quarter. If no Euro Foreign Exchange Reference Rate is determined for the
relevant currency the parties shall agree upon another reference rate.


 


7.5.3                        Records; Audit Rights; Disputes.


 


(a)                                   Records
of Revenues and Expenses; Audit Rights.  Each Party will maintain complete and
accurate records which are relevant to the determination of Development Costs,
and royalty payments under this Agreement and such records shall be open during
reasonable business hours for a period of two (2) years from creation of
individual records for examination at the other Party’s expense and not more
often than once each calendar year by a


 


20

















 


certified public accountant selected by the other Party (subject to the
consent of the Party to be audited, such consent not to be unreasonably
withheld or delayed), or the other Party’s internal accountants (unless the
Party to be audited objects to the use of such internal accountants) for the
sole purpose of verifying for the inspecting Party the correctness of
calculations and classifications of such Development Costs and royalty payments
under this Agreement.  Each Party shall
bear its own Costs related to such audit; provided, that, for any
underpayments greater than [*****] of annual Development Costs and/or royalty
payments (as the case may be) by the audited Party, the audited Party shall pay
the other Party the amount of underpayment, together with interest as provided
herein, from the time the amount was due and the inspecting Party’s
out-of-pocket expenses related to the audit. 
For any underpayments less than [*****] of annual Development Costs
and/or royalty payments (as the case may be), found under this Section, the audited
Party shall pay the inspecting Party the amount of the underpayment.  Any overpayments by the audited Party will
be refunded to the audited Party or credited to future payments by the audited
Party to the inspecting Party, at the audited Party’s election.


 


(b)                                  Resolution
of Payment Disputes. 
Except as set forth in this Section, the provisions of Section 13.6
shall not be applicable to disputes described in this Section.  If there is a dispute between the Parties
following any audit performed pursuant to this Section (an “Audit Disagreement”):
(i) within thirty (30) business days of the identification of the Audit
Disagreement and notice thereof to the other Party, the Parties shall jointly
select a recognized international accounting firm to act as an independent
expert to resolve such Audit Disagreement; (ii) the Audit Disagreement
submitted for resolution shall be described by the Parties to the independent
expert, which description may be in written or oral form, within ten (10)
business days of the selection of such independent expert; (iii) the
independent expert shall render a decision on the matter as soon as
practicable; (iv) the decision of the independent expert shall be final and
binding unless such Audit Disagreement involves alleged fraud, breach of this
Agreement or construction or interpretation of any of the terms and conditions
thereof, which Audit Disagreements shall be resolved as set forth in Section
13.6; and (v) all fees and expenses of the independent expert, including any
Third Party support staff or other costs incurred with respect to carrying out
the procedures specified at the direction of the independent expert in
connection with such Audit Disagreement, shall be borne by each Party in
inverse proportion to the disputed amounts awarded to such Party by the independent
expert through such decision (e.g., EPIX disputes $100; the independent expert
awards EPIX $60; EPIX pays for forty percent (40%) of the independent expert’s
costs, and SCHERING pays for sixty percent (60%) of the independent expert’s
costs.)


 


(c)                                   Payments;
Interest.  Any payments
due under this Agreement shall be due on such date as specified in the
Agreement and, in the event such date is not a business day, then the next
succeeding business day.  Any failure by
a Party to make a payment within ten (10) days after the date when due shall
obligate such Party to pay computed interest, the interest period commencing on
the due date and ending on the payment day, to the receiving Party at a rate
per annum equal [*****].  The interest
shall be computed on the basis of a 365/360 year; interest shall be compounded
annually in arrears.  Such interest
shall be due and payable on the tender of the underlying principle payment.


 


21

















 


(d)                                  Financial
Procedures.  Each Party
shall include in any agreement with its Affiliates or sublicensees terms
requiring such party to retain records as required in this Section 7.5.3 and to
permit the such Party to inspect such records as required by this Section
7.5.3.


 


7.5.4                        Taxes.  Each
Party shall pay any and all taxes levied on 
account of signing fees, research and development funding, milestone
payments, royalties or other payments received from the other Party under this
Agreement. If laws or regulations require that taxes be withheld by the paying
Party on any such payments, the paying Party shall: (i) deduct those taxes from
the remittable payment; (ii) timely pay the deducted taxes to the proper taxing
authority; and (iii) send proof of payment to the receiving Party within thirty
(30) days of receipt of confirmation of payment from the relevant taxing
authority.


 


7.5.5                        Retained Rights.  Each Party reserves the right to practice all Know-How and Patent
Rights that it may Control to the extent not expressly subject to a right, license
or option hereunder.  No rights are
granted hereunder by implication or estoppel.


 


8.                                       TERMINATION


 


8.1                                 Term.  The term
of this Agreement shall commence on the Effective Date and shall continue until
the last to occur of the following: (i) the tenth (10th) anniversary
of the expiration or termination of the Research Program Term and (ii) the
expiration or termination of the License Term for the last Licensed Product
(the “Term”).


 


8.2                                 Termination By Either Party.  This Agreement may be terminated partially
or in its entirety at any time by either Party as follows:


 


8.2.1                        Termination for Breach.   If either Party commits a material breach
of this Agreement, the other Party may notify the breaching Party in writing of
such breach, setting forth the nature of the breach in reasonable detail.  If the breaching Party fails to cure such
breach within thirty (30) days (in the case of a payment due under this
Agreement) or sixty (60) days (in the case of any other breach) of the receipt
of the foregoing notice from the non-breaching Party, then, subject to the
terms of this Section 8.2.1, the non-breaching Party may terminate (i) the
respective Part of this Agreement which is impacted by the uncured material
breach, or (ii) if the breach is of a general nature having a material impact
on all Parts, the entire Agreement effective immediately upon a second written
notice to the breaching Party. The right of either Party to terminate this
Agreement as herein above provided shall not be affected in any way by its waiver
of, or failure to take action with respect to any previous default.


 


8.2.2                        Termination for Insolvency.  In the event that either Party files for
protection under bankruptcy laws, makes an assignment for the benefit of
creditors, appoints or suffers appointment of a receiver or trustee over its
property, files a petition under any bankruptcy or insolvency act or has any
such petition filed against it which is not discharged within sixty (60) days
of the filing thereof, then the other Party may terminate this Agreement
effective immediately upon written notice to such Party.


 


22

















 


8.2.3                        Termination for Convenience.  Either Party may terminate the Research
Program upon six (6) months prior written notice to the other Party.  Either Party may terminate any license
granted to it hereunder upon written notice to the other Party.  Neither Party may, under this Section 8.2.3,
terminate a license or option granted to the other Party under this Agreement.


 


8.3                                 Consequences of Termination.  In the event of a termination of this
Agreement in part or in its entirety pursuant to Section 8.2 above, all
Proprietary Materials shall be returned by each Party to the Party which
Controls such Proprietary Materials to the extent required by the fact of a
partial or total termination of this Agreement.


 


8.4                                 Surviving Provisions.  Termination and expiration of this Agreement
for any reason shall be without prejudice to:


 


(a)                                   the
rights and obligations of the Parties herein which survive such expiration or
termination by their terms, including without limitation, those provided in
Sections 2.2.4, 4.4, 6.4, 7.3, 7.4, 7.5, 8.3, 8.4, 9.3.2, 13.4, 13.5, 13.6
and Articles 9, 10, 11 and 12, all of which shall survive such expiration or termination;
and


 


(b)                                  any
other rights or remedies provided at law or equity which either Party may
otherwise have against the other.


 


9.                                       INTELLECTUAL PROPERTY RIGHTS


 


9.1                                 Disclosure of Inventions.  Each Party shall promptly inform the other
about all Know-How that is conceived, made or developed in the course of
carrying out the Research Program by employees or agents of either of them or
their Affiliates, alone or jointly with employees or consultants of the other
Party or its Affiliates.


 


9.2                                 Ownership.


 


9.2.1                        EPIX Background Technology.  As between the Parties, EPIX shall have sole
and exclusive ownership of all right, title and interest on a worldwide basis
in and to any and all EPIX Background Technology with full rights to license or
sublicense, subject to the obligations to SCHERING as set forth herein.


 


9.2.2                        SCHERING Background Technology.  As between the Parties, SCHERING shall have
sole and exclusive ownership of all right, title and interest on a worldwide
basis in and to any and all SCHERING Background Technology, with full rights to
license or sublicense, subject to the obligations to EPIX as set forth herein.


 


9.2.3                        Joint Technology  .  SCHERING and EPIX shall jointly own all
Joint Technology, subject to the rights of, and the licenses granted to, each
Party hereunder.


 


9.3                                 Patent Coordinators.  EPIX and SCHERING shall each appoint a
Patent Coordinator, reasonably acceptable to the other Party, who shall serve
as such Party’s primary


 


23

















 


liaison with the
other Party on matters relating to patent filing, prosecution, maintenance and
enforcement.  Each Party may replace its
Patent Coordinator at any time by notice in writing to the other Party. The
initial Patent Coordinators shall be:


 


For EPIX:                                                                                            Dr.
Alan McEwen


 


For SCHERING:                                                           Dr.
Norbert Schwarz


 


The Patent Coordinators
will have responsibility for managing all Joint Patent Rights claiming Joint
Know-How as set forth in Section 9.4.1.


 


9.4                                 Patent Filing, Prosecution and Maintenance.


 


9.4.1                        Patent Filing, Prosecution and Maintenance of
Joint Patent Rights.  The
Parties, acting through the Patent Coordinators, shall be jointly responsible
for preparing, filing, prosecuting, obtaining and maintaining all Joint Patent
Rights.  The Parties will share equally
the expense of such efforts; provided, however, that either Party may decide
not to share such expenses, on a country-by-country basis, and thereafter such
Joint Patent Rights, in such country, shall be deemed to be exclusively owned
by the other Party.  The Parties shall
jointly select patent attorneys and agents to assist them in such efforts.


 


9.4.2                        Patent Filing, Prosecution and Maintenance by EPIX.  Subject to the other terms of this
Section 9, EPIX shall be responsible for preparing, filing, prosecuting,
obtaining and maintaining, at its sole cost, expense and discretion, and acting
through patent attorneys or agents of its choice, all EPIX Patent Rights. With
regard to those EPIX Patent Rights relevant to the actual research projects
being conducted during the Research Program Term EPIX: (i) will keep the
Patent Coordinators reasonably informed of the status of such filing,
prosecution and maintenance, including, without limitation: (a) by
providing the Patent Coordinators with copies of all communications received
from or filed in patent office(s) with respect to such filing, and (b) by
providing the Patent Coordinators a reasonable time prior to taking or failing
to take any action that would affect the scope or validity of any such of any
such filing (including the substantially narrowing, cancellation or abandonment
of any claim(s) without retaining the right to pursue such subject matter in a
separate application, or the failure to file or perfect the filing of any
claim(s) in any country), with prior written notice of such proposed action or
inaction so that the Patent Coordinators have a reasonable opportunity to
review and comment.


 


9.4.3                        Patent
Filing, Prosecution and Maintenance by SCHERING. 
Subject to the other terms of this Section 9, SCHERING shall be
responsible for preparing, filing, prosecuting, obtaining and maintaining, at
its sole cost, expense and discretion, and acting through patent attorneys or
agents of its choice, all SCHERING Patent Rights. With regard to those SCHERING
Patent Rights relevant to the actual research projects being conducted during
the Research Program Term SCHERING will keep the Patent Coordinators
reasonably informed of the status of such filing, prosecution and maintenance,
including, without limitation: (a) by


 


24

















 


providing the
Patent Coordinators with copies of all communications received from or filed in
patent office(s) with respect to such filing, and (b) by providing the
Patent Coordinators a reasonable time prior to taking or failing to take any
action that would affect the scope or validity of any such of any such filing
(including the substantially narrowing, cancellation or abandonment of any
claim(s) without retaining the right to pursue such subject matter in a
separate application, or the failure to file or perfect the filing of any
claim(s) in any country), with prior written notice of such proposed action or
inaction so that the Patent Coordinators have a reasonable opportunity to
review and comment.


 


9.5                                 Infringement of Patent Rights.


 


9.5.1                        Infringement of Joint Patent Rights.  The Parties shall jointly determine whether
to bring suit (or take other appropriate legal action) against any actual,
alleged or threatened infringement of Joint Patent Rights.  If both Parties desire to take such action,
they shall jointly determine how to share the expense and proceeds, if any, of
the action and they shall jointly choose legal counsel.  If either Party declines to take any such
action, the other Party shall have the right (but not the obligation), at its
own expense, to bring suit (or take other appropriate legal action) against
such actual, alleged or threatened infringement, with legal counsel of its own
choice, but shall not be permitted to settle any such suit without the prior
consent of the other Party, which consent shall not be unreasonably
withheld.  Any damages, monetary awards
or other amounts recovered, whether by judgment or settlement, pursuant to any
suit, proceeding or other legal action taken by a single Party under this
Section shall applied as follows:


 


(a)                                  First,
to reimburse the Party bringing such action for it’s costs and expenses
(including reasonable attorneys’ fees and costs) incurred in prosecuting such
enforcement action;


 


(b)                                 Second,
the remainder shall be divided between the Parties with [*****] to the Party
bringing such action and the remaining [*****] to the other Party.


 


9.5.2                        Infringement of EPIX Patent Rights.  EPIX shall have the first right (but not the
obligation), at its own expense and with legal counsel of its own choice, to
bring suit (or take other appropriate legal action) against any actual, alleged
or threatened infringement of EPIX’ Patent Rights in the Field.  SCHERING shall have the right, at its own
expense, to be represented in any such action by EPIX by counsel of SCHERING’s
own choice; provided, however, that under no circumstances shall
the foregoing affect the right of EPIX to control the suit as described in the
first sentence of this Section.  If EPIX
does not file any action or proceeding against such infringement within six (6)
months after the later of (i) EPIX’s notice to SCHERING under Section
9.5.4, (ii) SCHERING’s notice to EPIX under Section 9.5.4, or (iii) a
written request from SCHERING to take action with respect to such infringement,
then SCHERING shall have the right (but not the obligation), at its own
expense, to bring suit (or take other appropriate legal action) against such
actual, alleged or threatened infringement, with legal counsel of its own
choice, but shall not be permitted to settle any such suit without the prior
consent of EPIX, which consent shall not be unreasonably withheld.  Any damages, monetary awards or other
amounts recovered, whether by judgment or settlement, pursuant to any suit,


 


25

















 


proceeding or
other legal action taken under this Section 9.5, shall applied as follows:


 


(a)                                  First,
to reimburse the Parties for their respective costs and expenses (including
reasonable attorneys’ fees and costs) incurred in prosecuting such enforcement
action;


 


(b)                                 Second,
to licensing Party in reimbursement for lost sales (net of royalties)
associated with Licensed Products and to the licensor Party in reimbursement
for lost royalties owing hereunder based on such lost sales;


 


(c)                                  Third,
any amounts remaining shall be allocated as follows: (a) if EPIX is the
Party bringing such suit or proceeding or taking such other legal action, one
hundred percent (100%) to EPIX, (b) if SCHERING is the Party bringing such
suit or proceeding or taking such other legal action, one hundred percent
(100%) to SCHERING, and (c) if the suit is brought jointly, fifty percent (50%)
to each Party.


 


9.5.3                        Infringement of SCHERING Patent Rights.  SCHERING shall have the first right (but not
the obligation), at its own expense and with legal counsel of its own choice,
to bring suit (or take other appropriate legal action) against any actual,
alleged or threatened infringement of SCHERING’s Patent Rights.  EPIX shall have the right, at its own
expense, to be represented in any such action by SCHERING by counsel of EPIX’s
own choice; provided, however, that under no circumstances shall
the foregoing affect the right of SCHERING to control the suit as described in
the first sentence of this Section 9.5.3. 
If SCHERING does not file any action or proceeding against such
infringement within six (6) months after the later of (i) SCHERING’s
notice to EPIX under Section 9.5.4, (ii) EPIX’s notice to SCHERING
under Section 9.5.4, or (iii) a written request from EPIX to take
action with respect to such infringement, then EPIX shall have the right (but
not the obligation), at its own expense, to bring suit (or take other
appropriate legal action) against such actual, alleged or threatened
infringement, with legal counsel of its own choice, but shall not be permitted
to settle any such suit without the prior consent of SCHERING, which consent
shall not be unreasonably withheld.  Any
damages, monetary awards or other amounts recovered, whether by judgment or
settlement, pursuant to any suit, proceeding or other legal action taken under
this Section 9.5, shall applied as follows:


 


(a)                                  First,
to reimburse the Parties for their respective costs and expenses (including
reasonable attorneys’ fees and costs) incurred in prosecuting such enforcement
action;


 


(b)                                 Second,
to licensing Party in reimbursement for lost sales (net of royalties)
associated with Licensed Products and to the licensor Party in reimbursement
for lost royalties owing hereunder based on such lost sales;


 


(c)                                  Third,
any amounts remaining shall be allocated as follows: (a) if SCHERING is
the Party bringing such suit or proceeding or taking such other legal action,
one hundred percent (100%) to SCHERING, (b) if EPIX is the Party bringing
such suit or proceeding


 


26

















 


or taking such other legal action, one hundred percent (100%) to EPIX,
and (c) if the suit is brought jointly, fifty percent (50%) to each Party.


 


9.5.4                        Notice of Infringement.  If either Party learns of any actual,
alleged or threatened infringement by a Third Party of any Patent Rights
related to the Research Program or any license granted under this
Agreement(that is EPIX Patent Rights, SCHERING Patent Rights and Joint Patent
Rights), such Party shall promptly notify the other Party and shall provide
such other Party with available evidence of such infringement.


 


9.5.5                        Infringement of Know-How.  Section 9.5 and the principles and
mechanisms set forth therein shall apply accordingly to any infringement of
unpatented Know-How related to the Research Program or any license granted
under this Agreement (that is EPIX Know-How, SCHERING Know-How and Joint
Know-How.


 


9.6                                 Cooperation.  If a Party brings any such action or
proceeding hereunder, the other Party agrees to be joined as party plaintiff if
necessary to prosecute such action or proceeding, and to give the Party
bringing such action or proceeding reasonable assistance and authority to file
and prosecute the suit; provided, however, that neither Party shall be required
to transfer any right, title or interest in or to any property to the other
Party or any Third Party to confer standing on a Party hereunder.


 


9.7                                 Patent Management.  The Parties agree to exercise their respective
rights to manage the filing, prosecution and maintenance of Patent Rights under
this Agreement in a manner, insofar as reasonably possible, that maximizes the
value of such Patent Rights within the Field.


 


10.                                 CONFIDENTIALITY


 


10.1                           Nondisclosure Obligations.


 


10.1.1                  General.  Except as provided in this Article 10,
during the Term and for a period of fifteen (15) years thereafter, both Parties
shall maintain in confidence and use only for purposes specifically authorized
under this Agreement: (i) information and data received from the other Party
resulting from or related to Know-How, the development of Lead Compounds,
Development Candidates and Licensed Products and (ii) all information and data
not described in clause (i) but supplied by the other Party under this
Agreement marked “Confidential.”  For
purposes of this Article10, information and data described in clause (i) or
(ii) shall be referred to as “Information.”


 


10.1.2                  Limitations.  To the extent it is reasonably necessary or
appropriate to fulfill its obligations or exercise its rights under this
Agreement, a Party may disclose Information it is otherwise obligated under
this Section 10.1 not to disclose to its Affiliates, sublicensees, consultants,
outside contractors and clinical investigators, on a need-to-know basis on
condition that such entities or persons enter into written agreements to keep
the Information confidential for the same time periods and to the same extent
as such Party is required to keep


 


27

















 


the Information
confidential. In addition a Party or its Affiliates or sublicensees may
disclose such Information to government or other regulatory authorities to the
extent that such disclosure is reasonably necessary to obtain patents or authorizations
to conduct clinical trials of, and to commercially market Licensed
Products.  However, for the avoidance of
doubt, the Parties state that neither SCHERING nor EPIX shall disclose
pre-clinical or clinical data of the contents or pre-clinical or clinical
study, reports derived from studies of Licensed Products that has been received
from the other Party to advertising agencies, marketing research consultants,
customers, healthcare professionals, consumers or regulatory agencies without
the prior written approval of the other Party.


 


The obligation not to
disclose Information shall not apply to any part of such Information that: (i)
is or becomes part of the public domain other than by unauthorized acts of the
Party obligated not to disclose such Information or those of its Affiliates or
Sublicensees; (ii) can be shown by competent evidence to have been disclosed to
the receiving Party or its or Sublicensees by a Third Party, provided, that
such Information was not obtained by such Third Party directly or indirectly
from the other Party under this Agreement pursuant to a confidentiality
agreement; (iii) can be shown by competent evidence, prior to disclosure under
this Agreement, to already have been in the possession of the receiving Party
or its Affiliates or Sublicensees, provided, that such Information was not
obtained directly or indirectly from the other Party under this Agreement
pursuant to a confidentiality agreement; (iv) can be shown by competent
evidence to have been independently developed by the receiving Party or its
Affiliates without breach of any of the provisions of this Agreement; or (v) is
disclosed by the receiving Party pursuant to interrogatories, requests for
information or documents, subpoena, civil investigative demand issued by a
court or governmental agency or as otherwise required by law; provided, that,
the receiving Party notifies the other Party immediately upon receipt thereof
so that such other Party (with the cooperation of the receiving Party) can seek
a protective order or other order limiting or preventing disclosure; and provided,
further, that the disclosing Party furnishes only that portion of the
Information which it is advised by counsel is legally required under the
circumstances.


 


10.1.3                  Terms of this Agreement.  Except as provided in Section 10.1.2 hereof,
EPIX and SCHERING each agree not to disclose any terms or conditions of this
Agreement to any Third Party without the prior written consent of the other
Party, except as required by applicable law. 
If either Party determines that it is required to file this Agreement
with the Securities and Exchange Commission or other governmental agency for
any reason, such Party shall request confidential treatment of such portions of
this Agreement as the Parties shall together determine is appropriate.  Notwithstanding the foregoing, prior to
execution of this Agreement, EPIX and SCHERING have agreed upon the substance
of information that can be used as a routine reference in the usual course of
business to describe the terms of this transaction, and EPIX and SCHERING may
disclose such information, as modified by mutual agreement from time to time,
without the other Party’s consent as may be necessary from time to time.


 


10.2                           Injunctive Relief.  The Parties hereto understand and agree that
remedies at law may be inadequate to protect against any breach of any of the
provisions of this Article 10 by


 


28

















 


either Party or
their employees, agents, officers or directors or any other person acting in
concert with it or on its behalf. 
Accordingly, each Party shall be entitled to the granting of injunctive
relief or other equitable relief by a court of Competent jurisdiction against
any action that constitutes any such breach of this Article 10, in addition to
any monetary damages to which a Party may be entitled.


 


11.                                 REPRESENTATIONS AND WARRANTIES


 


11.1                           Representations and Warranties.  EPIX and SCHERING each represent and warrant
to the other, as of the Effective Date as follows:


 


11.2                           Organization.  It is a corporation duly organized, validly
existing and is in good standing under the laws of the jurisdiction of its
organization, is qualified to do business and is in good standing as a foreign
corporation in each jurisdiction in which the performance of its obligations
hereunder requires such qualification and has all requisite power and
authority, corporate or otherwise, to conduct its business as now being
conducted, to own, lease and operate its properties and to execute, deliver and
perform this Agreement.


 


11.3                           Authorization.  The execution, delivery and performance by
it of this Agreement: (a) have been duly authorized by all necessary corporate
action and (b) do not and will not violate any provision of any agreement, law,
rule, regulation, order, writ, judgment, injunction, decree, determination or
award presently in effect having applicability to it or any provision of its
charter documents.


 


11.4                           No Inconsistent Obligation.  It is not under any obligation to any
person, or entity, contractual or otherwise, that is conflicting or
inconsistent in any respect with the terms of this Agreement or that would
impede the diligent and complete fulfillment of its obligations hereunder and
that it has all power and authority under all instruments or agreements to
which it is a Party to enter into this Agreement and to perform its obligations
hereunder.


 


11.5                           Warranty Disclaimer.  EXCEPT AS OTHERWISE EXPRESSLY PROVIDED IN
THIS AGREEMENT, NEITHER PARTY MAKES ANY WARRANTY WITH RESPECT TO ANY
TECHNOLOGY, GOODS, SERVICES, RIGHTS OR OTHER SUBJECT MATTER OF THIS AGREEMENT
AND HEREBY DISCLAIMS WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR
PURPOSE AND NONINFRINGEMENT WITH RESPECT TO ANY AND ALL OF THE FOREGOING.


 


12.                                 INDEMNITY


 


12.1                           Claim.  For
purposes of this Article 12 “Claim” shall mean any and all Third Party suits,
actions, claims, demands, liabilities, expenses, and/or losses, including
without limitation reasonable attorneys fees, based upon, arising in connection
with, or resulting from the development, clinical study in humans, or
commercialization of Lead Compounds, Development Candidates and Licensed
Products excluding any suits, actions, claims, demands, liabilities, expenses,
and/or losses based upon, arising in connection with, or resulting from
infringement of


 


29

















 


the intellectual property rights (including without limitation patent
rights) of any Third Party or Third Parties.


 


12.2                           SCHERING Indemnity
Obligations.  Subject to
the provisions of Sections 12.3 and 12.4, SCHERING agrees to defend, indemnify
and hold EPIX, its Affiliates and their respective directors, officers,
employees and agents harmless from all Claims against EPIX, its Affiliates or
their respective directors, officers, employees or agents solely based upon,
arising in connection with or resulting from (a) actual or asserted violations
of any applicable law or regulation by SCHERING, its Affiliates, sublicensees,
or agents by virtue of which any Lead Compound, Development Candidate, or
Licensed Product is developed, distributed or sold by SCHERING shall be alleged
or determined to be adulterated, misbranded, mislabeled or otherwise not in
compliance with such applicable law or regulation, (b) the manufacture, use,
sale or promotion of Lead Compounds, Development Candidates or Licensed
Products by SCHERING; (c) any negligent or willful or intentional act or
omission to act by SCHERING, its Affiliates, sublicensees, or agents in any
manner in connection with performance hereunder; or (d) the breach of any
representation or warranty of SCHERING in this Agreement.


 


12.3                           EPIX Indemnity Obligations.  Subject to the provisions of Sections 12.2
and 12.4, EPIX agrees to defend, indemnify and hold SCHERING, its Affiliates
and their respective directors, officers, employees and agents harmless from
all Claims against SCHERING, its Affiliates or their respective directors,
officers, employees or agents solely based upon, arising in connection with or
resulting from (a) actual or asserted violations of any applicable law or
regulation by EPIX, its Affiliates, sublicensees, or agents by virtue of which
any Lead Compound, Development Candidate, or Licensed Product is developed,
distributed or sold by EPIX shall be alleged or determined to be adulterated,
misbranded, mislabeled or otherwise not in compliance with such applicable law
or regulation, (a) the manufacture, use, sale or promotion of Lead Compounds,
Development Candidates or Licensed Products; (b) any negligent or willful or
intentional act or omission to act by EPIX, its Affiliates, sublicensees or
agents in any manner in connection with performance hereunder; or (c) the
breach of any representation or warranty of EPIX in this Agreement.


 


12.4                           Procedure.  A Party or any of its Affiliates (the
“Indemnitee”) that intends to claim indemnification under this Sections 12.2 or
12.3 shall promptly notify the other Party (the “Indemnitor”) of the Claim in
respect of which the Indemnitee intends to claim such indemnification, and the
Indemnitor shall assume the defense thereof with counsel mutually ‘satisfactory
to the Parties; provided, however, that an Indemnitee shall have
the right to retain its own counsel, with the fees and expenses to be paid by
the Indemnitor, if representation of such Indemnitee by the counsel retained by
the Indemnitor,  would be inappropriate
due to actual or potential differing interests between such Indemnitee and any
other Party represented by such counsel in such proceedings. An Indemnitee
shall not be entitled to indemnification under Sections 12.2 or 12.3 if any
settlement or compromise of a Claim is effected by the Indemnitee without the
consent of the Indemnitor, which consent shall not be unreasonably withheld or
delayed.  The failure to deliver notice
to the Indemnitor within a reasonable time after notice of a Claim, if
prejudicial to its ability to defend such action, shall relieve such Indemnitor
of any


 


30

















 


liability to the
Indemnitee under Sections 12.2 or 12.3. 
The Indemnitee under Sections 12.2 or 12.3, its employees and agents
(and those of any indemnified Affiliates or other Indemnitees), shall cooperate
fully with the Indemnitor and its legal representatives in the investigation
and defense of the Claim covered by this indemnification.  Any Costs paid by an Indemnitor shall be
without prejudice to the Indemnitor’s right to contest the Indemnitee’s right
to be indemnified, and subject to refund in the event that the Indemnitor is
ultimately held not to be obligated to indemnify the Indemnitee.


 


12.5                           Limited Liability.  NOTWITHSTANDING ANYTHING TO THE CONTRARY IN
THIS AGREEMENT, NEITHER EPIX NOR SCHERING WILL BE LIABLE WITH RESPECT TO ANY
SUBJECT MATTER OF THIS AGREEMENT UNDER ANY CONTRACT, NEGLIGENCE, STRICT
LIABILITY OR OTHER LEGAL OR EQUITABLE THEORY FOR LOST PROFITS.


 


13.                                 MISCELLANEOUS


 


13.1                           Force Majeure.  Neither Party shall be held liable or
responsible to the other Party nor be deemed to have defaulted under or
breached this Agreement for failure or delay in fulfilling or performing any
term of this Agreement when such failure or delay is caused by or results from
causes beyond the reasonable control of the affected Party, including but not
limited to fire, floods, embargoes, war, acts of war (whether war is declared
or not), insurrections, riots, civil commotions, strikes, lockouts or other
labor disturbances, acts of God or acts, omissions or delays in acting by any
governmental authority; provided, however, that the Party so affected shall use
reasonable commercial efforts to avoid or remove such causes of nonperformance,
and shall continue performance hereunder with reasonable dispatch whenever such
causes are removed. Either Party shall provide the other Party with prompt
written notice of any delay or failure to perform that occurs by reason of
force majeure.  The Parties shall
mutually seek a resolution of the delay or the failure to perform as noted
above.


 


13.2                           Assignment.  This Agreement may not be assigned or
otherwise transferred by either Party without the prior written consent of the
other Party; provided, however, that either EPIX or SCHERING may,
without such consent, assign its rights and obligations under this agreement:
(i) to any Affiliate, or (ii) in connection with a merger, consolidation or
sale of substantially all of such Party’s assets to an unrelated Third Party; provided,
however, with respect to this Subsection (ii), that the other Party has
the right to terminate with immediate effect the Research Program Term under
this Agreement; provided, further, with respect to this
Subsection (ii), that such Party’s rights and obligations under this Agreement
shall be assumed in writing by its successor in interest in any such
transaction and shall not be transferred separately from all or substantially
all of its diagnostic imaging business assets. 
Any purported assignment in violation of the preceding sentence shall be
void.  Any permitted assignee shall
assume all obligations of its assignor under this Agreement.


 


13.3                           Severability.  Each Party hereby agrees that it does not
intend, by its execution hereof, to violate any public policy, statutory or
common laws, rules, regulations, treaty or


 


31

















 


decision of any
government agency or executive body thereof of any country or community or
association of countries.  Should one or
more provisions of this Agreement be or become invalid, the Parties hereto
shall substitute, by mutual consent, valid provisions for such invalid provisions
which valid provisions in their economic and other effects are sufficiently
similar to the invalid provisions that it can be reasonably assumed that the
Parties would have entered into this Agreement with such valid provisions.  In case such valid provisions cannot be
agreed upon, the invalidity of one or several provisions of this Agreement
shall not affect the validity of this Agreement as a whole or the validity of
any portions hereof, unless the invalid provisions are of such essential
importance to this Agreement that it is to be reasonably assumed that the
Parties would not have entered into this Agreement without the invalid
provisions.


 


13.4                           Notices.  Any
consent, notice or report required or permitted to be given or made under this
Agreement by one of the Parties hereto to the other shall be in writing,
delivered personally or by courier, postage prepaid (where applicable),
addressed to such other Party at its address indicated below, or to such other
address as the addressee shall have last furnished in writing to the addressor
and shall be effective upon receipt by the addressee.


 


If to
EPIX:                                                                                         EPIX
Medical, Inc.


71
Rogers Street


Cambridge,
Massachusetts 02142-1118


Attention:  Chief Executive Officer


 


with a
copy to:                                                                 Mintz
Levin, Cohn, Ferris, Glovsky and Popeo, P.C.


One
Financial Center


Boston,
Massachusetts 02111


Attention:  William T. Whelan, Esq.


 


If to
SCHERING:                   SCHERING
Aktiengesellschaft


13342
Berlin


Germany


Attention:  Head of Corporate Research


 


with a
copy to:                                                                 SCHERING
Aktiengesellschaft


13342
Berlin


Germany


Attention:  Legal Department


 


13.5                           Applicable Law.  This Agreement shall be governed by and
construed in accordance with the laws of the State of New York, without giving
effect to the choice of laws provisions thereof.


 


13.6                           General Dispute Resolution.


 


13.6.1                  Negotiation.  Subject to any other dispute resolution
principles and mechanisms set forth in this Agreement, the Parties hereby agree
that they will attempt in good


 


32

















 


faith to, resolve any controversy or claim arising out of or relating
to this Agreement promptly by negotiations. 
If a controversy or claim should arise hereunder, the representatives of
the Parties will confer at least once and will attempt to resolve the matter.   If the matter has not been resolved within
fourteen (14) Business Days of their first meeting, the representatives shall
refer the matter to the Chief Executive Officer of EPIX and the Head of
Corporate Research of SCHERING.  If the
matter has not been resolved within thirty (30) Business Days of the first
meeting of the Chief Executive Officer of EPIX and the Head of Corporate
Research of SCHERING (which period may be extended by mutual agreement),
subject to rights to injunctive relief and specific performance, and unless
otherwise specifically provided for herein, any controversy or claim arising
out of or relating to this Agreement, or the breach thereof, will be settled as
set forth in Section 13.6.2, unless provided otherwise in this Agreement.


 


13.6.2                  Arbitration.  All disputes, controversies or differences
which may arise between the Parties out of or in relation to this Agreement or
any default or breach thereof may be resolved by arbitration in accordance with
the commercial arbitration rules (except as otherwise specified herein) of the
American Arbitration Association by three arbitrators, one to be selected by
each of the Parties from a list of arbitrators supplied by the American
Arbitration Association within thirty days of receipt of such list, and a third
to be selected by the first two from such list within a reasonable time. The
arbitrators shall be experienced in the subject matter of the arbitration (for
example, arbitration of a scientific issue would require appointment of
arbitrators with knowledge of the relevant area of science).  The arbitration shall take place in New
York, New York.  Either Party may
initiate an arbitration by written not ice to the other Party, such notice
shall set forth the particulars of the issue to be arbitrated in sufficient
detail to permit the Party receiving the notice to conduct an investigation and
formulate a position (such notice shall not preclude the Parties from
attempting to informally settle their differences).  The arbitrators shall select one of their number to serve as
presiding arbitrator, with the responsibility for handling administrative
matters relating to the arbitration. 
Within sixty days of written notice to the Parties of the selection of
the third arbitrator, each Party shall contemporaneously submit in writing to
the presiding arbitrator and the other Party its position for the resolution of
the issue that is the subject matter of the arbitration.  At the request of either Party, to be submitted
to the presiding arbitrator and the other Party within sixty days receipt of
the written position of the other Party, the arbitrators shall schedule
in-person presentations of the Parties (at which both parties and all three
arbitrators shall be present), which may include the presentation of witnesses,
oral argument, or both, at the discretion of each of the Parties, and which
shall not exceed five hours for each of the Parties.  The in-person presentations shall be scheduled by the arbitrators
at their convenience and the reasonable convenience of the Parties, but shall
be held within ninety and one hundred fifty days of receipt by the presiding
arbitrator of the first request for an in-person presentation.  If neither Party makes a request for an in person
presentation, then the decision of the arbitrators shall be based solely on the
written positions of the Parties.  The
arbitrators shall have the power only to select one of the Party’s positions,
and the decision of any two of the arbitrators shall be the result of the
arbitration.  The non-prevailing Party
shall bear the costs of the arbitration. 
The decision resulting from the arbitration provided for herein shall be
final and binding on the Parties hereto. 
Notwithstanding the above, without resort to arbitration in the first
instance, either Party has the right to bring suit against the other Party for:


 


33

















 


(i) any breach of
such other Party’s duties of confidentiality pursuant to Article 10 of this
Agreement and (ii) any infringement of its own proprietary rights by the other
Party.  Judgment upon the arbitrators’
award may be entered in any court of competent jurisdiction.  The Parties agree not to institute any
litigation or proceedings against each other in connection with this Agreement
unless they have complied with the provisions of this Section 13.6.2, as they
may be applicable, unless otherwise provided herein.


 


13.7                           Public Announcements.  Anything in Article 10 to the contrary
notwithstanding, the Parties agree that press releases and other announcements
to be made by either of them in relation to this Agreement shall be subject to
the written consent of the other Party, which consent shall not be unreasonably
withheld or delayed, except to the extent that any such press release is
required to be made by law or the rules of any national stock exchange and the
consent of the other Party is not obtained after reasonable efforts to do
so.  The Parties will agree to issue a
joint press release immediately following the execution of this Agreement, the
form and content of which shall be reasonably satisfactory to both Parties.


 


13.8                           Entire Agreement; Amendment.  This Agreement, together with the exhibits
hereto, contain the entire understanding of the Parties with respect to the
subject matter hereof.  All express or
implied agreements and understandings, either oral or written, heretofore made
are expressly merged in and made a part of this Agreement and the other
agreements described in this Section. 
This Agreement may be amended, or any term hereof modified, only by a
written instrument duly executed by both Parties hereto.


 


13.9                           Headings.  The captions to the several Articles and Sections hereof are not
a part of this Agreement, but are merely guides or labels to assist in locating
and reading the several Articles and Sections hereof.


 


13.10                     Agreement Not to Solicit Employees.  During the Term and for a period of two (2)
years following the expiration or termination of this Agreement, EPIX and
SCHERING agree not to seek to persuade or induce any employee of the other
company to discontinue his or her employment with that company in order to
become employed by or associated with any business, enterprise or effort that
is associated with its own business.


 


13.11                     Exports.  The
Parties acknowledge that the export of technical data, materials or products is
subject to the exporting Party receiving any necessary export licenses and that
the Parties cannot be responsible for any delays attributable to export
controls which are beyond the reasonable control of either Party.  EPIX and SCHERING agree not to export or
re-export, directly or indirectly, any information, technical data, the direct
product of such data, samples or equipment received or generated under this
Agreement in violation of any applicable export control laws or governmental
regulations.  EPIX and SCHERING agree to
obtain similar covenants from their licensees, Sublicensees and contractors
with respect to the subject matter of this Section 13.11.


 


13.12                     Waiver.  The
waiver by either Party hereto of any right hereunder shall not be


 


34

















 


deemed a waiver of
any other right hereunder whether of a similar nature or otherwise.


 


13.13                     Counterparts.  This Agreement may be executed in two or
more counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.


 


13.14                     Independent Contractors; Negation
of Partnership.  The
relationship of EPIX and SCHERING established by this Agreement is that of
independent contractors, and nothing contained in this Agreement shall be
construed to give either Party the power to direct or control the day-to-day
activities of the other, or allow one Party to create or assume an obligation
on behalf of the other Party for any purpose whatsoever.  This Agreement is not intended to create a
partnership between EPIX and SCHERING for United States federal income tax
purposes (as defined in Section 761 of the Internal Revenue Code), for any
state or local jurisdiction in the United States, of for any country other than
the United States.  Therefore, there is
no requirement in the United States to file Form 1065, United States
Partnership Return of Income, or any similar state or local income tax return
in any political subdivision of the United States, or any similar tax document
in any country other than the United States, in regard to the contractual
relationship described in this Agreement.


 


13.15                     Ambiguities.  The Parties acknowledge and agree that: (i)
each Party and its counsel reviewed and negotiated the terms and provisions of
this Agreement and have contributed to its revision; (ii) the rule of
construction to the effect that any ambiguities are resolved against the
drafting Party shall not be employed in the interpretation of this Agreement;
and (iii) the terms and provisions of this Agreement shall be construed fairly
as to all Parties hereto and not in a favor of or against any Party, regardless
of which Party was generally responsible for the preparation of this Agreement.


 


 


IN WITNESS WHEREOF, the
Parties have executed this Agreement as of the date first set forth above.


 


	
  EPIX MEDICAL, INC.

  
	
   

  	
   

  
	
   

  	
   

  
	
  By:

  	
   

  	
   

  
	
   

  	
  Michael D. Webb

  
	
   

  	
  Chief Executive Officer

  



 


35

















 


	
  SCHERING
  AKTIENGESELLSCHAFT

  
	
   

  	
   

  	
   

  
	
  By:

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Prof. Dr. Günter Stock

  
	
   

  	
  Member of the Vorstand

  
	
   

  	
   

  
	
   

  	
   

  
	
  By:

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  Prof. Dr. Björn
  Wallmark

  
	
   

  	
  Head of Corporate
  Research

  



 


36

















 


Exhibit 1.13


 


EPIX Patent Rights


The following patent
families constitute existing utility applications assigned to EPIX or in the
case of the MET-1 patent family exclusively licensed from The General Hospital
Corporation of Boston, Massachusetts (Agreement of March 24, 1992 amended July
10, 1995).  MET-9 is assigned to Dyax
and EPIX with EPIX having exclusive rights to MRI applications (Agreement of
June 20, 1997 amended March 17, 2003).


 


	
  MET-1

  	
   

  	
  US

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  US-CIP

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  EPO

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  CANADA

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  HONG KONG

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  LATVIA

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  SINGAPORE

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-3

  	
   

  	
  US

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-4

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  AUSTRALIA

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  ISRAEL

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  NEW ZEALAND

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  SINGAPORE

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  SOUTH AFRICA

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  SWAZILAND

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  TAIWAN

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-5

  	
   

  	
  US CON Publication

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  EPO

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  AUSTRALIA

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  CHINA

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  ISRAEL

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  NEW ZEALAND

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  SINGAPORE

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-6

  	
   

  	
  US

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  AUSTRALIA

  	
   

  	
  [*****]

  



 


37

















 


	
   

  	
   

  	
  NEW ZEALAND

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-7

  	
   

  	
  AUSTRALIA

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  EPO

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  NEW ZEALAND

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-8

  	
   

  	
  US

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-9

  	
   

  	
  US Application

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-10

  	
   

  	
  US

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-11

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-12

  	
   

  	
  US

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-14

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-15

  	
   

  	
  PCT

  	
   

  	
  [*****]

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  MET-16

  	
   

  	
  US Publication

  	
   

  	
  [*****]

  
	
   

  	
   

  	
  PCT

  	
   

  	
  [*****]

  



 


38

















 


Exhibit
1.15


 


Products of SCHERING in Development or Commercialized


 


1.              Commercialized
Products


 


Magnevist (gadopentetate
dimeglumine)


Gadovist  (gadobutrol)


Resovist (ferucarbotran)


Feridex (ferumoxide)


Teslascan (mangafodipir
trisodium)


 


2. Products in Development


[*****]


 


39

















 


Exhibit 1.49


 


Schering Patent Rights


 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  02346A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/FEB/2003

  
	
  02346A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  NO

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/FEB/2003

  
	
  02346A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/SEP/2004

  
	
  02346A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  31/DEC/2007

  
	
  02346A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/FEB/2003

  
	
  02346A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  21/JUN/2005

  
	
  02346A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/FEB/2003

  
	
  02346A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/FEB/2003

  
	
  02346A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2001

  
	
  02346A

  	
   

  	
  DE 0071564

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  02346A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/SEP/2003

  
	
  02346A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/FEB/2003

  
	
  02346A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/AUG/2005

  
	
  02346A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  02346A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/JUL/2007

  
	
  02346A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/JUL/2002

  
	
  02346A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  22/JUL/2002

  
	
  02346A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/FEB/2003

  
	
  02346A

  	
   

  	
  CA

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  03/MAR/2004

  
	
  02346A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  
	
  02346A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2002

  
	
  02346A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  23/JUL/2002

  



 


40

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/OCT/2013

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/JUN/2008

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/MAR/2004

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/MAR/2004

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/NOV/2011

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/MAR/2004

  
	
  02491A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  SG

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  02491A

  	
   

  	
  IT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/MAR/2004

  
	
  02491A

  	
   

  	
  SG

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  GB

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  10/JAN/2004

  
	
  02491A

  	
   

  	
  NL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JAN/2004

  
	
  02491A

  	
   

  	
  LU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  BE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/JAN/2004

  
	
  02491A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  GR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  GB

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  AT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  15/SEP/2011

  
	
  02491A

  	
   

  	
  ES

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/NOV/2004

  
	
  02491A

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  CH

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2006

  
	
  02491A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2004

  
	
  02491A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  09/APR/2004

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02491A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/JUN/2008

  
	
  02491A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JAN/2004

  



 


41

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  02491A

  	
   

  	
  SG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JAN/2004

  
	
  02491A

  	
   

  	
  SG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JAN/2004

  
	
  02575A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  11/JAN/2004

  
	
  02575A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  11/JAN/2004

  
	
  02969A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUL/2007

  
	
  02969A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  30/JAN/2018

  
	
  02969A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2006

  
	
  02969A

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2007

  
	
  02969A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2007

  
	
  02969A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2007

  
	
  02969A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/JUL/2007

  
	
  02969A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2007

  
	
  02969A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/DEC/2007

  
	
  02969A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2007

  
	
  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/FEB/2016

  
	
  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02969A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  02969A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUL/2007

  
	
  03035A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/NOV/2007

  
	
  03035A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  03035A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  14/SEP/2010

  
	
  03035A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/NOV/2006

  
	
  03035A

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  10/NOV/2007

  
	
  03035A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/NOV/2007

  
	
  03035A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/NOV/2007

  
	
  03035A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/NOV/2007

  



 


42

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  03035A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/NOV/2007

  
	
  03035A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/NOV/2007

  
	
  03035A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  06/MAR/2008

  
	
  03035A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  23/NOV/2007

  
	
  03035A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/MAR/2009

  
	
  03035A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  03035A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/MAR/2016

  
	
  03035A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  30/NOV/2007

  
	
  03035A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  03035A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/NOV/2007

  
	
  03193A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/FEB/2009

  
	
  03193A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  03193A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/OCT/2014

  
	
  03193A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/OCT/2014

  
	
  03226A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/MAR/2009

  
	
  03226A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/FEB/2011

  
	
  03226A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50116A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  11/AUG/2009

  
	
  50116A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/JAN/2011

  
	
  50235A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2013

  
	
  50235A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/JUN/2010

  
	
  50235A

  	
   

  	
  DD

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2008

  
	
  50235A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/JUN/2010

  
	
  50235A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/JUN/2010

  
	
  50235A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50235A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/JUN/2010

  
	
  50235A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/NOV/2011

  
	
  50235A

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  



 


43

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  50235A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2010

  
	
  50235A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/JUN/2010

  
	
  50235A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/NOV/2010

  
	
  50235A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/JUN/2010

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/AUG/2015

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/MAR/2017

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  09/DEC/2014

  
	
  50235A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50235A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUN/2010

  
	
  50298A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/NOV/2010

  
	
  50298A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/SEP/2014

  
	
  50298A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/JUL/2014

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  15/NOV/2011

  
	
  50298A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/NOV/2010

  
	
  50298A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  21/NOV/2010

  
	
  50340A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2016

  
	
  50340A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  



 


44

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  50340A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JAN/2015

  
	
  50340A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2013

  
	
  50340A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/JAN/2015

  
	
  50340A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/MAR/2016

  
	
  50340A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/MAR/2016

  
	
  50340A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  GR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/MAR/2016

  
	
  50340A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2016

  
	
  50340A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/MAR/2016

  
	
  50340A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  50340A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  24/FEB/2017

  
	
  50340A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2011

  
	
  50340A

  	
   

  	
  SE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  18/MAR/2016

  
	
  50340A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  09/NOV/2016

  
	
  50340A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/MAR/2011

  
	
  50340A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50340A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50340A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50351A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/APR/2011

  
	
  50351A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/APR/2011

  
	
  50351A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/APR/2011

  
	
  50351A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/APR/2011

  
	
  50351A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/APR/2011

  
	
  50351A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/APR/2011

  
	
  50351A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/APR/2011

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  12/JAN/2016

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/APR/2011

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/DEC/2015

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/APR/2011

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  



 


45

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  50351A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/APR/2011

  
	
  50384A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/NOV/2011

  
	
  50384A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
   

  
	
  50384A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JAN/2014

  
	
  50384A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  07/NOV/2011

  
	
  50384A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/NOV/2011

  
	
  50396B

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  06/DEC/2011

  
	
  50396B

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  IL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  06/DEC/2012

  
	
  50396B

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  07/DEC/2012

  
	
  50396B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2012

  
	
  50396B

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  06/DEC/2012

  
	
  50396B

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50396B

  	
   

  	
  AT

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  BE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  DK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  FR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  LU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  NL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  ES

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  CH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  GR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  GB

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  SE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  PT

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  MC

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  IT

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/2012

  
	
  50396B

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/DEC/2012

  



 


46

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  50449A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  11/MAY/2012

  
	
  50449A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  13/MAY/2012

  
	
  50449A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  IE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/MAY/2012

  
	
  50449A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/MAY/2012

  
	
  50449A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2012

  
	
  50449A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/MAY/2012

  
	
  50449A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/MAY/2012

  
	
  50449A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  13/APR/2012

  
	
  50449A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  27/JUN/2012

  
	
  50449A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  07/MAY/2012

  
	
  50479A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUN/2012

  
	
  50479A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/MAY/2013

  
	
  50479A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50479A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  



 


47

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  50479A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  07/DEC/2012

  
	
  50479A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50580A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/SEP/2013

  
	
  50580A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/SEP/2012

  
	
  50580A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/SEP/2013

  
	
  50580A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/SEP/2013

  
	
  50580A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/SEP/2013

  
	
  50580A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  15/DEC/2015

  
	
  50580A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/SEP/2013

  
	
  50658A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  24/JAN/2014

  
	
  50658A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  ID

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  10/MAR/2014

  
	
  50658A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2014

  
	
  50658A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  MY

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  31/JUL/2015

  
	
  50658A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50658A

  	
   

  	
  TH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  24/JAN/2014

  
	
  50658A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  11/MAR/2014

  
	
  50658A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/AUG/2014

  
	
  50658A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/JAN/2014

  
	
  50659A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/NOV/2014

  
	
  50659A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/NOV/2014

  
	
  50659A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/NOV/2014

  
	
  50659A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/NOV/2014

  
	
  50735A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/NOV/2013

  
	
  50735A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  



 


48

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  50735A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  06/NOV/2012

  
	
  50735A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/OCT/2013

  
	
  50735A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50735A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/NOV/2013

  
	
  50784A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/JAN/2014

  
	
  50856A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/APR/2014

  
	
  50856A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2013

  
	
  50856A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  50856A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/MAY/2015

  
	
  51041A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2014

  
	
  51041A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2014

  
	
  51041A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2014

  
	
  51041A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2014

  
	
  51041A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2014

  
	
  51041A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51041A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/JUN/2015

  
	
  51081A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/JAN/2015

  
	
  51081A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/JAN/2015

  
	
  51081A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51108A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  



 


49

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51108A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  07/JUL/2014

  
	
  51108A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2015

  
	
  51108A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51108A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/JUN/2015

  
	
  51108A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/JUN/2015

  
	
  51121A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/JUN/2015

  
	
  51121A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/JUN/2015

  
	
  51126A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/JUN/2015

  
	
  51130A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2018

  
	
  51130A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  02/JUN/2017

  
	
  51130A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2018

  
	
  51130A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2012

  
	
  51130A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2018

  
	
  51130A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2018

  
	
  51130A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  28/MAY/2018

  
	
  51130A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  01/JUN/2018

  
	
  51130A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/JUN/2018

  
	
  51130A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51130A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/JUN/2018

  
	
  51142A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  09/JUL/2016

  
	
  51142A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51142A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51142A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/JUN/2017

  
	
  51152A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  21/FEB/2015

  
	
  51152A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  07/JUN/2015

  
	
  51155A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  01/MAR/2015

  
	
  51155A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  



 


50

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51155A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/FEB/2016

  
	
  51155A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/FEB/2016

  
	
  51155A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/MAR/2010

  
	
  51155A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/MAR/2016

  
	
  51156A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  27/JAN/2015

  
	
  51156A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  FI

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  HK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/JAN/2016

  
	
  51156A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  



 


51

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51156A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JAN/2016

  
	
  51156A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/JAN/2016

  
	
  51164A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/AUG/2014

  
	
  51164A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2015

  
	
  51164A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/JUL/2015

  
	
  51164A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  10/JUL/2015

  
	
  51164A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JUL/2015

  
	
  51201A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  08/MAY/2015

  
	
  51201A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  08/MAY/2015

  
	
  51201A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  08/MAY/2015

  
	
  51201A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  08/MAY/2015

  
	
  51201A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  08/MAY/2015

  
	
  51229A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/FEB/2016

  
	
  51237A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  07/JUN/2015

  
	
  51246A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/NOV/2016

  
	
  51246A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/NOV/2016

  
	
  51246A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/NOV/2016

  
	
  51246A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/NOV/2016

  
	
  51246A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51263A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/APR/2016

  
	
  51282A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  BR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  04/JUL/2015

  
	
  51282A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  



 


52

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51282A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  PK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/FEB/2018

  
	
  51282A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  RU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/SEP/2011

  
	
  51282A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  03/JUL/2016

  
	
  51282A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/JUL/2016

  
	
  51282A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51282A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/JUL/2010

  
	
  51282A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/JUL/2016

  
	
  51282A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51282A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/JUN/2016

  
	
  51285A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2016

  
	
  51285A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  



 


53

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51285A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51285A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  25/FEB/2017

  
	
  51285A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/DEC/1997

  
	
  51285A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51285A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/FEB/2017

  
	
  51315A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  04/JAN/2016

  
	
  51315A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51315A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  BR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  



 


54

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51322A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JAN/2016

  
	
  51322A

  	
   

  	
  EE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  IS

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  PK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/FEB/2018

  
	
  51322A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  RU

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/JAN/2012

  
	
  51322A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  17/JAN/2017

  
	
  51322A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/JAN/2017

  
	
  51322A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/JAN/2017

  
	
  51322A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/JAN/2017

  
	
  51322A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/FEB/1997

  
	
  51322A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51322A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  17/JAN/2017

  
	
  51322A

  	
   

  	
  LV

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  LT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  RO

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  16/JAN/2017

  
	
  51322A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  16/JAN/2017

  
	
  51358A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  



 


55

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51358A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  22/DEC/2015

  
	
  51358A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  RU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  20/DEC/2011

  
	
  51358A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51358A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/JAN/1997

  
	
  51358A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51358A

  	
   

  	
  VN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51358A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51358A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/DEC/2016

  
	
  51358A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  LI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51358A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/NOV/2016

  
	
  51378A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  26/SEP/2017

  
	
  51378A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/SEP/2018

  
	
  51378A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/OCT/1998

  



 


56

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  51378A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51378A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  CY

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51378A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  17/AUG/2018

  
	
  51412B

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  BA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  BR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  MK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  RO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  SI

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  SK 2

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  TR

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51412B

  	
   

  	
  YU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  



 


57

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  51412B

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51412B

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2018

  
	
  51433A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/AUG/2017

  
	
  51433A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2007

  
	
  51433A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  NZ

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  29/JUL/2017

  
	
  51433A

  	
   

  	
  TH

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  04/AUG/2017

  
	
  51433A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/AUG/2012

  
	
  51433A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/AUG/2017

  
	
  51433A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51433A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  05/AUG/2017

  
	
  51433A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  01/AUG/2017

  
	
  51437A

  	
   

  	
  AU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  04/DEC/2016

  
	
  51437A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  



 


58

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  51437A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51437A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/NOV/2017

  
	
  51437A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2017

  
	
  51437A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51437A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  04/DEC/2017

  
	
  51457A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  04/DEC/2016

  
	
  51457A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51457A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/NOV/2017

  
	
  51457A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/NOV/2017

  
	
  51457A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  25/NOV/2017

  
	
  51457A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2017

  
	
  51457A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51457A

  	
   

  	
  ZA

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  04/DEC/2017

  
	
  51479A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/JUL/1998

  
	
  51502A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  03/JUL/2017

  
	
  51502A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  28/MAY/2018

  
	
  51502A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAY/2018

  
	
  51502A

  	
   

  	
  TW

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  02/JUL/2013

  
	
  51502A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUN/2018

  
	
  51502A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/JUN/2018

  
	
  51502A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/JUL/1998

  
	
  51502A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51502A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  03/JUL/2018

  
	
  51502A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/OCT/2022

  
	
  51519A

  	
   

  	
  KP

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/SEP/2013

  
	
  51521A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  10/MAR/2020

  
	
  51521A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  22/FEB/2021

  
	
  51521A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  08/MAR/2021

  
	
  51521A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/SEP/2001

  
	
  51521A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51521A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  22/FEB/2021

  
	
  51521A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  22/FEB/2021

  
	
  51538A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  24/SEP/2018

  
	
  51538A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51538A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  26/SEP/2017

  
	
  51538A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51538A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51538A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2018

  
	
  51538A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  24/SEP/2018

  
	
  51538A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/OCT/1998

  
	
  51538A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51545A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/MAR/2019

  
	
  51545A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  



 


59

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51545A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2014

  
	
  51545A

  	
   

  	
  JP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/MAR/2020

  
	
  51545A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/APR/2000

  
	
  51545A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51545A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51545A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/MAR/2020

  
	
  51547A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/DEC/2017

  
	
  51547A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/DEC/2018

  
	
  51547A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/DEC/2018

  
	
  51547A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/DEC/2018

  
	
  51547A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  07/JAN/1999

  
	
  51547A

  	
   

  	
  WO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51549A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51562A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/1999

  
	
  51562A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51563A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/DEC/1999

  
	
  51563A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51564A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51590A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  03/APR/2018

  
	
  51613A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  24/JUL/2018

  
	
  51613A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/JUL/2019

  
	
  51613A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/JUL/2019

  
	
  51613A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/JUL/2019

  
	
  51613A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  02/JUL/2014

  
	
  51613A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  23/JUL/2019

  
	
  51613A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  30/OCT/1999

  
	
  51613A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51614A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  22/SEP/2018

  
	
  51614A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  21/SEP/2019

  
	
  51614A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/NOV/1999

  
	
  51614A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51614A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  



 


60

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51614A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  CY

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51614A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  20/AUG/2019

  
	
  51645A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  CN

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  A 17/NOV/2019

  
	
  51645A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  02/DEC/2018

  
	
  51645A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  HK

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/NOV/2019

  
	
  51645A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  01/DEC/2019

  
	
  51645A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/JAN/2000

  
	
  51645A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51645A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  17/NOV/2019

  
	
  51658A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/SEP/2018

  
	
  51669A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/SEP/2019

  
	
  51669A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  28/SEP/2020

  
	
  51669A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  29/SEP/2020

  
	
  51669A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/OCT/2000

  
	
  51684A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51729A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  29/SEP/2019

  
	
  51729A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  28/SEP/2020

  
	
  51729A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  29/SEP/2020

  
	
  51729A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/OCT/2000

  
	
  51729A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  12/JUL/2022

  
	
  51734A

  	
   

  	
  PE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734A

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51734A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JUL/2021

  
	
  51734A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734A

  	
   

  	
  UY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/JUL/2022

  
	
  51734A

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51734A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51734B

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734B

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51734B

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  20/JUL/2021

  
	
  51734B

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  



 


61

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51734B

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51734B

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51734B

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51734B

  	
   

  	
  UY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/JUL/2022

  
	
  51734B

  	
   

  	
  PE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2022

  
	
  51735A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  08/OCT/2000

  
	
  51752A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  06/AUG/2019

  
	
  51752A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  25/JUL/2020

  
	
  51752A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  25/JUL/2020

  
	
  51752A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/AUG/2020

  
	
  51752A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/AUG/2000

  
	
  51752A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51760A

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  11/AUG/2020

  
	
  51760A

  	
   

  	
  PH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51760A

  	
   

  	
  TH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51760A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2016

  
	
  51760A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51760A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/SEP/2001

  
	
  51760A

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  HR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  YU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  HK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51760A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  EE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  BR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2015

  
	
  51760A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  CO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51760A

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  



 


62

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51761A

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  BR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  HR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51761A

  	
   

  	
  EE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  KR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  YU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2015

  
	
  51761A

  	
   

  	
  HK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51761A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  CO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51761A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51761A

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51761A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  11/AUG/2020

  
	
  51761A

  	
   

  	
  PH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51761A

  	
   

  	
  TH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51761A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2016

  
	
  51761A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51761A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/SEP/2001

  
	
  51761A

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51761A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51762A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51762A

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51762A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  11/AUG/2020

  
	
  51762A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  17/AUG/2016

  
	
  51762A

  	
   

  	
  US

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  10/AUG/2021

  
	
  51762A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  26/SEP/2001

  
	
  51762A

  	
   

  	
  UY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  07/AUG/2021

  
	
  51762A

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51762A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51762A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  BG

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  CO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  



 


63

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51762A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2015

  
	
  51762A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  YU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  BR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  HK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51762A

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  EE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  HU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51762A

  	
   

  	
  HR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51762A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  23/JUL/2021

  
	
  51766A

  	
   

  	
  AE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2015

  
	
  51766A

  	
   

  	
  AT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  AU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  BE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  BG

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  BR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  BY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  CA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  CH

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  CN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  CY

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  CZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  DK

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  EE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  EP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  ES

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  FI

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  FR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  GB

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  GR

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  HR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51766A

  	
   

  	
  HU

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  ID

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  IE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  IL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  IN

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2014

  
	
  51766A

  	
   

  	
  IT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  JP

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  KR

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  



 


64

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant
  number

  	
   

  	
  Expiry

  
	
  51766A

  	
   

  	
  LU

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  MC

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  MX

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  NL

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  NZ

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  PL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  PT

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  RU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  SE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  09/SEP/2019

  
	
  51766A

  	
   

  	
  SK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/SEP/2015

  
	
  51766A

  	
   

  	
  UA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/SEP/2019

  
	
  51766A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  11/SEP/2020

  
	
  51766A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51766A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51766A

  	
   

  	
  YU

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  ZA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/SEP/2020

  
	
  51766A

  	
   

  	
  HK

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51766A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  11/SEP/2020

  
	
  51768A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JAN/2022

  
	
  51768A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  26/JAN/2021

  
	
  51768A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/JAN/2022

  
	
  51768A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  13/FEB/2002

  
	
  51768A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51769A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  06/APR/2021

  
	
  51769A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  24/APR/2002

  
	
  51772A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/MAR/2017

  
	
  51780A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/OCT/2019

  
	
  51800A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
  [*****]

  	
   

  	
  13/JAN/2020

  
	
  51800A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  27/JAN/2001

  
	
  51800A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51832A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  20/DEC/2022

  
	
  51834A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/DEC/2021

  
	
  51834A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  14/DEC/2021

  
	
  51834A

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51834A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  15/DEC/2020

  
	
  51834A

  	
   

  	
  JO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  02/JUL/2022

  
	
  51834A

  	
   

  	
  PE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  13/DEC/2021

  
	
  51834A

  	
   

  	
  SA

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51834A

  	
   

  	
  TH

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  14/DEC/2021

  
	
  51834A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  07/NOV/2016

  
	
  51834A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  13/DEC/2021

  
	
  51834A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/DEC/2001

  
	
  51834A

  	
   

  	
  UY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/DEC/2021

  
	
  51834A

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  51834A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51954A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  15/SEP/2020

  



 


65

















 


	
  File number

  	
   

  	
  Country C

  	
   

  	
  Publication
  number

  	
   

  	
  Grant number

  	
   

  	
  Expiry

  
	
  51954A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  14/SEP/2016

  
	
  51954A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  14/SEP/2021

  
	
  51954A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  27/SEP/2001

  
	
  51954A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  51954A

  	
   

  	
  EP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/SEP/2021

  
	
  51954A

  	
   

  	
  JP

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/SEP/2021

  
	
  51954A

  	
   

  	
  NO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  05/SEP/2021

  
	
  52024A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/MAR/2022

  
	
  52024A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52024A

  	
   

  	
  WO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  15/NOV/2022

  
	
  52024A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52162A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  18/JUN/2021

  
	
  52163A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
  [*****]

  	
   

  	
  19/JUN/2021

  
	
  52163A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUN/2022

  
	
  52163A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  52164A

  	
   

  	
  DE

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
  11/JUL/2021

  
	
  52164A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  11/JUL/2022

  
	
  52164A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  18/JUL/2002

  
	
  52164A

  	
   

  	
  WO

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52165A

  	
   

  	
  AR

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2022

  
	
  52165A

  	
   

  	
  CL

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52165A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2021

  
	
  52165A

  	
   

  	
  PE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2022

  
	
  52165A

  	
   

  	
  TW

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  09/JUL/2022

  
	
  52165A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  07/OCT/2022

  
	
  52165A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/JUL/2002

  
	
  52165A

  	
   

  	
  VE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52165A

  	
   

  	
  WO

  	
   

  	
  [*****]

  	
   

  	
   

  	
   

  	
   

  
	
  52165A

  	
   

  	
  UY

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  28/JUN/2022

  
	
  52207A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  22/OCT/2002

  
	
  52231A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/APR/2023

  
	
  52231A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  52307A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  16/JUL/2003

  
	
  52307A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  10/JUL/2022

  
	
  52308A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  13/DEC/2022

  
	
  52308A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  12/FEB/2004

  
	
  52309A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  19/FEB/2023

  
	
  52309A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  06/MAR/2004

  
	
  52335A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/APR/2023

  
	
  52335A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  11/APR/2004

  
	
  53061A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/FEB/2023

  
	
  53061A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  12/FEB/2004

  
	
  53063A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  03/APR/2023

  
	
  53063A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  53072A

  	
   

  	
  DE

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  04/FEB/2023

  
	
  53072A

  	
   

  	
  US

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  12/FEB/2004

  



 


66

















 


Exhibit
2.4 A


 


Lead Compound
Criteria for a Small Molecule


 


In general, these are not “exclusion criteria” but are intended to
provide the project team with a clear set of optimization variables that are
the basis for the decision-making process and will be investigated in the lead
compound optimization phase of the project.


 


Target:


The target has been
validated [*****], and [*****], etc.)


 


Approaches without defined target:


For compounds [*****] an
[*****] of [*****] in [*****] the [*****] of [*****] to [*****].  If possible, [*****].


 


The lead compound:


•                  Has
[*****], i.e., [*****] and [*****] the [*****].


•                  Has
shown [*****].


•                  For
projects with a [*****], the [*****] at [*****]


•                  For
projects [*****], the [*****] at [*****].


•                  Has
a [*****] plan. [*****].


•                  [*****]
have been [*****].


•                                          [*****]:
[*****] using [*****] as well as [*****].


•                                          [*****]:
[*****], [*****] and [*****].


•                  If
[*****], an [*****] of the [*****] is [*****].


•                  [*****]
for [*****] has been [*****].


•                  [*****]
such as [*****] as well as [*****].


•                  Allows
for [*****].


 


Biological
screening models


 


If possible, the [*****]
and [*****] should have been [*****] or [*****] in the [*****].  If [*****] these should also [*****].  The [*****] should be [*****], allow [*****]
[*****] and be [*****]  The [*****]
should have [*****] or [*****].  In
particular, the [*****] for [*****]  If
available, [*****]
should be included in the [*****].


 


Extract from:


[*****]


 


67

















 


Exhibit
2.4 B


 


Criteria needed to
make a Development Candidate decision


 


The development candidate
decision [*****] [*****] resulting in the [*****]


 


The development candidate compound should fulfill the criteria listed
below, which should serve as reference points rather than as strict rules:
there will be cases where some criteria are not applicable or where deviations
are justified. In general, the following criteria should be met:


 


•                  [*****]


•                  [*****]
and expected [*****]


•                  [*****]
on third party [*****]


•                  [*****],
[*****] and [*****] for the [*****] in [*****]


•                  if
possible, information available on [*****] with [*****] and [*****]


•                  appropriate
[*****]   [*****]   relevant to the [*****] at [*****], where [*****] and [*****]


•                  expectation
of [*****] for the [*****] based on [*****]
and [*****])


•                  expectation
of [*****] in relation to [*****] for the [*****]


 


Extract from :


[*****]


 


68