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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549





FORM 10-Q







|x | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ---------------------------------------------------------------------------------------

FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2010

or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

FOR THE TRANSITION PERIOD FROM TO

Commission File Number: 1-33428





Pharmasset, Inc.

(Exact name of registrant as specified in its charter)







|                                                               |  |                                  
|-------------------------------------------------------------- |  | ---------------------------------
|DELAWARE                                                       |  | 98-0406340                       
|(State or other jurisdiction of incorporation or organization) |  | (IRS Employer Identification No.)
|                                                               | 
|303-A College Road East
Princeton, New Jersey                  |  | 08540                            
|(Address of registrants principal executive offices)          |  | (Zip Code)                       

(609) 613-4100

(Telephone number, including area code)

N/A

(Former Name, Former Address and Former Fiscal Year, if Changed Since Last Report)

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past
90 days.    x  Yes     ̈  No

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate website, if any, every Interactive
Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such
files).     ̈  Yes     ̈  No

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer or a smaller
reporting company. See definition of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the Exchange Act.



|                        |  |   |  |                           |  |  
|----------------------- |  | - |  | ------------------------- |  | -
|Large accelerated filer |  |  ̈ |  | Accelerated filer         |  | x
|                        |  |   | 
|Non-accelerated filer   |  |  ̈ |  | Smaller reporting company |  |  ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange
Act).     ̈  Yes    No  x

The number of shares of the registrants common stock, $0.001 par value, outstanding as of July 30, 2010 was 33,984,692.











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PHARMASSET, INC.

FORM 10-Q

FOR THE QUARTER ENDED JUNE 30, 2010

INDEX



|           |  |                                                                                                                       |  |     
|---------- |  | --------------------------------------------------------------------------------------------------------------------- |  | ----
|           |  |                                                                                                                       |  | Page
|           |  |                                                                                                                      
|PART 1.    |  | FINANCIAL INFORMATION                                                                                                 |  |     
|           |  |                                                                                                                      
|Item 1.    |  | Financial Statements                                                                                                  |  | 4   
|           |  |                                                                                                                      
|           |  | Condensed Balance Sheets as of June 30, 2010 (Unaudited) and September 30, 2009                                       |  | 4   
|           |  |                                                                                                                      
|           |  | Condensed Statements of Operations for the Three and Nine Months Ended June 30, 2010 (Unaudited) and 2009 (Unaudited) |  | 5   
|           |  |                                                                                                                      
|           |  | Condensed Statements of Cash Flows for the Nine Months Ended June 30, 2010 (Unaudited) and 2009 (Unaudited)           |  | 6   
|           |  |                                                                                                                      
|           |  | Notes to Financial Statements (Unaudited)                                                                             |  | 7   
|           |  |                                                                                                                      
|Item 2.    |  | Managements Discussion and Analysis of Financial Condition and Results of Operations                                 |  | 19  
|           |  |                                                                                                                      
|Item 4.    |  | Controls and Procedures                                                                                               |  | 39  
|           |  |                                                                                                                      
|PART II.   |  | OTHER INFORMATION                                                                                                     |  |     
|           |  |                                                                                                                      
|Item 1.    |  | Legal Proceedings                                                                                                     |  | 39  
|           |  |                                                                                                                      
|Item 1A.   |  | Risk Factors                                                                                                          |  | 39  
|           |  |                                                                                                                      
|Item 6.    |  | Exhibits                                                                                                              |  | 40  
|           | 
|SIGNATURES |  | 41                                                                                                                   



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FORWARD-LOOKING STATEMENTS

This Quarterly Report on Form 10-Q contains forward-looking statements. The forward-looking statements are principally contained in the
sections entitled Business and Managements Discussion and Analysis of Financial Condition and Results of Operations. These statements involve known and unknown risks, uncertainties, and other factors that may cause our
actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. For this purpose, any statement that is not a statement of
historical fact should be considered a forward-looking statement. We may, in some cases, use words such as project, believe, anticipate, plan, expect, estimate,
intend, potential, or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. These forward-looking statements include statements about the following:



| |  |  | our product development efforts, primarily with respect to the preclinical and clinical trial results and regulatory approval of RG7128, PSI-7977,
PSI-938, and PSI-661 for the treatment of hepatitis C virus (HCV) and, secondarily, the development of
RacivirTMfor the treatment of human immunodeficiency
virus (HIV);
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the initiation, termination, completion, or success of preclinical studies and clinical trials;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | clinical trial initiation and completion dates, anticipated regulatory filing dates, and regulatory approval for our product candidates;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the commercialization of our product candidates;
| | - |  | ------------------------------------------------



| |  |  | our collaboration agreement with F. Hoffmann-LaRoche Ltd. and Hoffmann-La Roche Inc. (collectively, Roche), including potential milestone
or royalty payments thereunder;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our intentions regarding the establishment of collaborations or the licensing of product candidates or intellectual property;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------



| |  |  | the scope and enforceability of our intellectual property rights, including claims that we or our collaborators may infringe third party intellectual
property rights or be otherwise required to pay license fees under such third party rights;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our intentions to expand our capabilities and hire additional employees;
| | - |  | ------------------------------------------------------------------------



| |  |  | anticipated operating losses, future revenues, research and development expenses, and the need for additional financing; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



| |  |  | our financial performance.
| | - |  | --------------------------

Forward-looking statements reflect our current views with respect to future events and are subject to risks and uncertainties. We discuss
many of the risks and uncertainties associated with our business in greater detail in our Annual Report on Form 10-K for the fiscal year ended September 30, 2009 under the heading Risk Factors. Given these risks and uncertainties,
you should not place undue reliance on these forward-looking statements. All forward-looking statements represent our estimates and assumptions only as of the date of this Quarterly Report on Form 10-Q.

You should read this Quarterly Report on Form 10-Q and the documents that we reference in it completely and with the understanding that
our actual future results may be materially different from what we expect. You should assume that the information appearing in this Quarterly Report on Form 10-Q is accurate as of the date on the front cover of this Quarterly Report on Form 10-Q
only. Our business, financial condition, results of operations, and prospects may change. We may not update these forward-looking statements, even though our situation may change in the future, unless we have obligations under the federal securities
laws to update and disclose material developments related to previously disclosed information. The forward-looking statements contained in this Quarterly Report on Form 10-Q are subject to the safe-harbor protection provided by the Private
Securities Litigation Reform Act of 1995 and Section 21E of the Securities Exchange Act of 1934, as amended (Exchange Act).



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PART 1. FINANCIAL INFORMATION



|ITEM 1. | FINANCIAL STATEMENTS
|------- | --------------------

PHARMASSET, INC.

CONDENSED BALANCE SHEETS

(in thousands, except par value, share and per share amounts)



|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ----------------- | -------- | - | ---------------------- | - | -------- | -
|                                                                                                                                                                             |  | As ofJune 30,2010 |          |   | As ofSeptember 30,2009 |  
|                                                                                                                                                                             |  | (unaudited)       |          |   |                        |  
|ASSETS                                                                                                                                                                       |  |                   |          |   |                        |   |          |  
|CURRENT ASSETS:                                                                                                                                                              |  |                   |          |   |                        |   |          |  
|Cash and cash equivalents                                                                                                                                                    |  | $                 | 144,374  |   |                        | $ | 58,408   |  
|Amounts due from collaboration partner                                                                                                                                       |  |                   | 10       |   |                        |   | 369      |  
|Prepaid expenses and other assets                                                                                                                                            |  |                   | 1,054    |   |                        |   | 1,656    |  
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|Total current assets                                                                                                                                                         |  |                   | 145,438  |   |                        |   | 60,433   |  
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|                                                                                                                                                                             |  |                  
|EQUIPMENT AND LEASEHOLD IMPROVEMENTS:                                                                                                                                        |  |                   |          |   |                        |   |          |  
|Equipment                                                                                                                                                                    |  |                   | 4,152    |   |                        |   | 3,613    |  
|Leasehold improvements                                                                                                                                                       |  |                   | 1,837    |   |                        |   | 1,837    |  
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|                                                                                                                                                                             |  |                   | 5,989    |   |                        |   | 5,450    |  
|Less accumulated depreciation and amortization                                                                                                                               |  |                   | (4,133   | ) |                        |   | (3,419   | )
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|Total equipment and leasehold improvements, net                                                                                                                              |  |                   | 1,856    |   |                        |   | 2,031    |  
|Restricted cash                                                                                                                                                              |  |                   | 100      |   |                        |   | 100      |  
|Other assets                                                                                                                                                                 |  |                   | 148      |   |                        |   | 172      |  
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|Total                                                                                                                                                                        |  | $                 | 147,542  |   |                        | $ | 62,736   |  
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|                                                                                                                                                                             |  |                  
|LIABILITIES AND STOCKHOLDERS EQUITY                                                                                                                                         |  |                   |          |   |                        |   |          |  
|CURRENT LIABILITIES:                                                                                                                                                         |  |                   |          |   |                        |   |          |  
|Current portion of long-term debt                                                                                                                                            |  | $                 | 8,824    |   |                        | $ | 7,513    |  
|Accounts payable                                                                                                                                                             |  |                   | 3,116    |   |                        |   | 2,533    |  
|Accrued expenses                                                                                                                                                             |  |                   | 4,746    |   |                        |   | 7,675    |  
|Deferred rent                                                                                                                                                                |  |                   |         |   |                        |   | 80       |  
|Deferred revenue                                                                                                                                                             |  |                   | 985      |   |                        |   | 985      |  
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|Total current liabilities                                                                                                                                                    |  |                   | 17,671   |   |                        |   | 18,786   |  
|                                                                                                                                                                             |  |                  
|Deferred revenue                                                                                                                                                             |  |                   | 2,217    |   |                        |   | 2,956    |  
|Long-term debt, net of discount of $214 and $472 as of June 30, 2010 and September 30, 2009,
respectively                                                                    |  |                   | 5,063    |   |                        |   | 12,096   |  
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|Total liabilities                                                                                                                                                            |  |                   | 24,951   |   |                        |   | 33,838   |  
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|                                                                                                                                                                             |  |                  
|Commitments and contingencies                                                                                                                                                |  |                   |          |   |                        |   |          |  
|                                                                                                                                                                             |  |                  
|STOCKHOLDERS EQUITY:                                                                                                                                                        |  |                   |          |   |                        |   |          |  
|Common stock, $0.001 par value, 100,000,000 shares authorized, 33,968,441 and 28,268,004 shares issued and outstanding at
June 30, 2010 and September 30, 2009, respectively |  |                   | 34       |   |                        |   | 28       |  
|Warrants to purchase 127,248 shares of common stock for $12.05 per share as of June 30, 2010 and September 30, 2009,
respectively                                            |  |                   | 1,230    |   |                        |   | 1,230    |  
|Additional paid-in capital                                                                                                                                                   |  |                   | 334,663  |   |                        |   | 195,025  |  
|Accumulated deficit                                                                                                                                                          |  |                   | (213,336 | ) |                        |   | (167,385 | )
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|Total stockholders equity                                                                                                                                                   |  |                   | 122,591  |   |                        |   | 28,898   |  
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  
|Total                                                                                                                                                                        |  | $                 | 147,542  |   |                        | $ | 62,736   |  
|                                                                                                                                                                             |  |                   |          |   |                        |   |          |  

See notes to financial statements.



4



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PHARMASSET, INC.

CONDENSED STATEMENTS OF OPERATIONS

(UNAUDITED)

(in thousands, except share and per share amounts)



|                                      |  |                            |            |   |                           |   |            |      |  |   |            |   |  |   |            |  
|------------------------------------- |  | -------------------------- | ---------- | - | ------------------------- | - | ---------- | ---- |  | - | ---------- | - |  | - | ---------- | -
|                                      |  | Three Months EndedJune 30, |            |   | Nine Months
EndedJune 30, |  
|                                      |  | 2010                       |            |   | 2009                      |   |            | 2010 |  |   | 2009       |  
|Revenues                              |  | $                          | 249        |   |                           | $ | 10,501     |      |  | $ | 769        |   |  | $ | 12,868     |  
|                                      |  |                            |            |   |                           |   |            |      |  |   |            |   |  |   |            |  
|                                      |  |                            |            |  
|COSTS AND EXPENSES:                   |  |                            |            |   |                           |   |            |      |  |   |            |   |  |   |            |  
|Research and development              |  |                            | 11,505     |   |                           |   | 13,677     |      |  |   | 32,731     |   |  |   | 41,394     |  
|General and administrative            |  |                            | 4,200      |   |                           |   | 2,995      |      |  |   | 12,086     |   |  |   | 9,958      |  
|                                      |  |                            |            |   |                           |   |            |      |  |   |            |   |  |   |            |  
|                                      |  |                            |            |  
|Total costs and expenses              |  |                            | 15,705     |   |                           |   | 16,672     |      |  |   | 44,817     |   |  |   | 51,352     |  
|                                      |  |                            |            |   |                           |   |            |      |  |   |            |   |  |   |            |  
|                                      |  |                            |            |  
|Operating loss                        |  |                            | (15,456    | ) |                           |   | (6,171     | )    |  |   | (44,048    | ) |  |   | (38,484    | )
|                                      |  |                            |            |  
|Investment income                     |  |                            | 1          |   |                           |   | 38         |      |  |   | 6          |   |  |   | 205        |  
|Interest expense                      |  |                            | (565       | ) |                           |   | (816       | )    |  |   | (1,909     | ) |  |   | (2,418     | )
|                                      |  |                            |            |   |                           |   |            |      |  |   |            |   |  |   |            |  
|                                      |  |                            |            |  
|Loss before income taxes              |  |                            | (16,020    | ) |                           |   | (6,949     | )    |  |   | (45,951    | ) |  |   | (40,697    | )
|Provision for income taxes            |  |                            |           |   |                           |   |           |      |  |   |           |   |  |   |           |  
|                                      |  |                            |            |   |                           |   |            |      |  |   |            |   |  |   |            |  
|                                      |  |                            |            |  
|Net loss                              |  | $                          | (16,020    | ) |                           | $ | (6,949     | )    |  | $ | (45,951    | ) |  | $ | (40,697    | )
|                                      |  |                            |            |   |                           |   |            |      |  |   |            |   |  |   |            |  
|                                      |  |                            |            |  
|Net loss per share: basic and diluted |  | $                          | (0.50      | ) |                           | $ | (0.25      | )    |  | $ | (1.54      | ) |  | $ | (1.57      | )
|                                      |  |                            |            |   |                           |   |            |      |  |   |            |   |  |   |            |  
|                                      |  |                            |            |  
|Weighted average shares outstanding:  |  |                            |            |   |                           |   |            |      |  |   |            |   |  |   |            |  
|basic and diluted                     |  |                            | 32,000,528 |   |                           |   | 28,121,400 |      |  |   | 29,932,398 |   |  |   | 25,907,063 |  
|                                      |  |                            |            |   |                           |   |            |      |  |   |            |   |  |   |            |  

See notes to financial statements.



5



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PHARMASSET, INC.

CONDENSED STATEMENTS OF CASH FLOWS

(UNAUDITED)

(in thousands)



|                                                                                                                       |  |                           |         |   |      |   |         |  
|---------------------------------------------------------------------------------------------------------------------- |  | ------------------------- | ------- | - | ---- | - | ------- | -
|                                                                                                                       |  | Nine Months EndedJune 30, |        
|                                                                                                                       |  | 2010                      |         |   | 2009 |  
|CASH FLOWS FROM OPERATING ACTIVITIES:                                                                                  |  |                           |         |   |      |   |         |  
|Net loss                                                                                                               |  | $                         | (45,951 | ) |      | $ | (40,697 | )
|Adjustments to reconcile net loss to net cash used in operating activities:                                            |  |                           |         |   |      |   |         |  
|Depreciation                                                                                                           |  |                           | 714     |   |      |   | 740     |  
|Non-cash stock compensation                                                                                            |  |                           | 4,293   |   |      |   | 3,570   |  
|Non-cash interest expense                                                                                              |  |                           | 316     |   |      |   | 415     |  
|Changes in operating assets and liabilities:                                                                           |  |                           |         |   |      |   |         |  
|Amounts due from collaboration partner, prepaid expenses and other assets                                              |  |                           | 927     |   |      |   | (609    | )
|Accounts payable                                                                                                       |  |                           | 584     |   |      |   | (277    | )
|Accrued expenses                                                                                                       |  |                           | (2,929  | ) |      |   | 1,796   |  
|Deferred rent                                                                                                          |  |                           | (80     | ) |      |   | (93     | )
|Deferred revenue                                                                                                       |  |                           | (739    | ) |      |   | (1,393  | )
|                                                                                                                       |  |                           |         |   |      |   |         |  
|Net cash used in operating activities                                                                                  |  |                           | (42,865 | ) |      |   | (36,548 | )
|                                                                                                                       |  |                           |         |   |      |   |         |  
|                                                                                                                       |  |                          
|CASH FLOWS FROM INVESTING ACTIVITIES:                                                                                  |  |                           |         |   |      |   |         |  
|Maturity of short-term investments                                                                                     |  |                           |        |   |      |   | 500     |  
|Purchase of equipment and leasehold improvements                                                                       |  |                           | (539    | ) |      |   | (200    | )
|                                                                                                                       |  |                           |         |   |      |   |         |  
|Net cash (used in) provided by investing activities                                                                    |  |                           | (539    | ) |      |   | 300     |  
|                                                                                                                       |  |                           |         |   |      |   |         |  
|                                                                                                                       |  |                          
|CASH FLOWS FROM FINANCING ACTIVITIES:                                                                                  |  |                           |         |   |      |   |         |  
|Borrowings of long-term debt                                                                                           |  |                           |        |   |      |   | 3,333   |  
|Proceeds from exercise of stock options                                                                                |  |                           | 1,446   |   |      |   | 582     |  
|Principal payments on long-term debt                                                                                   |  |                           | (5,980  | ) |      |   | (1,466  | )
|Principal payments on capital lease obligations                                                                        |  |                           |        |   |      |   | (42     | )
|Proceeds from issuances of common stock, net of issuance costs of $7,111 and $2,092 during 2010 and 2009,
respectively |  |                           | 133,904 |   |      |   | 43,425  |  
|                                                                                                                       |  |                           |         |   |      |   |         |  
|Net cash provided by financing activities                                                                              |  |                           | 129,370 |   |      |   | 45,832  |  
|                                                                                                                       |  |                           |         |   |      |   |         |  
|                                                                                                                       |  |                          
|Net increase in cash and cash equivalents                                                                              |  |                           | 85,966  |   |      |   | 9,584   |  
|Cash and cash equivalents - Beginning of period                                                                        |  |                           | 58,408  |   |      |   | 63,073  |  
|                                                                                                                       |  |                           |         |   |      |   |         |  
|Cash and cash equivalents - End of period                                                                              |  | $                         | 144,374 |   |      | $ | 72,657  |  
|                                                                                                                       |  |                           |         |   |      |   |         |  
|                                                                                                                       |  |                          
|SUPPLEMENTAL DISCLOSURES:                                                                                              |  |                           |         |   |      |   |         |  
|Cash paid during the period for:                                                                                       |  |                           |         |   |      |   |         |  
|Interest                                                                                                               |  | $                         | 1,593   |   |      | $ | 2,003   |  
|                                                                                                                       |  |                          
|Noncash transactions:                                                                                                  |  |                           |         |   |      |   |         |  
|Value of warrants granted in connection with debt financing                                                            |  | $                         |        |   |      | $ | 90      |  

See notes to financial statements.



6



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Pharmasset, Inc.

Notes to Financial Statements (Unaudited)

1. DESCRIPTION OF BUSINESS AND BASIS OF PRESENTATION

Description of Business-Pharmasset, Inc. (Pharmasset or the
Company) is a clinical-stage pharmaceutical company committed to discovering, developing, and commercializing novel drugs to treat viral infections. The Companys primary focus is on the development of nucleoside/tide analogs as
oral therapeutics for the treatment of chronic hepatitis C virus (HCV) infection and, secondarily, on the development of
RacivirTMfor the treatment of human immunodeficiency
virus (HIV) infection. Nucleoside/tide analogs are a class of compounds which act as alternative substrates for the viral polymerase, thus inhibiting viral replication. The Company currently has four clinical-stage product candidates,
three of which it is developing itself and one of which it is developing with a strategic partner. The Company is also advancing a series of preclinical candidates in preparation for clinical development. The Companys four clinical stage
product candidates are:



| |  |  | RG7128, an HCV cytosine nucleoside analog polymerase inhibitor the Company is developing through a strategic collaboration with F. Hoffmann-La Roche
Ltd and Hoffmann-La Roche Inc. (collectively, Roche). RG7128 recently completed 12 weeks of dosing in a Phase 2b PROPEL clinical trial in combination with
Pegasys® (pegylated interferon) plus
Copegus® (ribavirin), the standard of care for treating HCV (SOC) and is also in a 24 week Phase 2b
clinical trial in combination with SOC. RG7128 is also being evaluated in the INFORM studies, the first series of studies designed to investigate the combination of two oral, direct acting antivirals (DAAs) in the absence of pegylated
interferon and ribavirin. All of these studies are being conducted by Roche;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | PSI-7977, an HCV uracil nucleotide analog polymerase inhibitor that recently completed 28 days of dosing in a Phase 2a clinical trial in combination
with SOC. We are planning for a Phase 2b clinical trial in combination with SOC that we expect to initiate during the fourth calendar quarter of 2010;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | PSI-352938 (PSI-938), an HCV guanine nucleotide analog polymerase inhibitor that is in a Phase 1 clinical trial; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------



| |  |  | Racivir, for the treatment of HIV in combination with other approved HIV drugs, which has completed a Phase 2 clinical trial.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------

The Company is subject to risks common to companies in the pharmaceutical industry including, but not
limited to, risks and uncertainties relating to product development, protection of proprietary intellectual property, compliance with government regulations, dependence on key personnel, the need to obtain additional financing, uncertainty of market
acceptance of products, and product liability. (See Part II, Item 1A. - Risk Factors for additional information.)

Basis of Presentation - The Company was incorporated as Pharmasset, Inc. under the laws of Delaware on June 8, 2004.
Management has evaluated subsequent events for disclosure or recognition in the accompanying financial statements up to the filing of this report.

The accompanying unaudited condensed financial statements have been prepared in accordance with accounting principles generally accepted
in the United States of America for interim financial information and with the instructions to Form 10-Q and Rule 10-01 of Regulation S-X. Accordingly, they do not contain all of the information and footnotes required for complete
financial statements. In the opinion of management, the accompanying unaudited condensed financial statements reflect all adjustments, which include normal recurring adjustments, necessary to present fairly the Companys interim financial
information. The accompanying unaudited condensed financial statements and notes to the condensed financial statements should be read in conjunction with the audited financial statements for the fiscal year ended September 30, 2009 included in
the Companys Annual Report on Form 10-K filed with the Securities and Exchange Commission (SEC) on November 25, 2009.



7



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2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Use of Estimates - The preparation of the Companys financial statements in conformity with accounting principles
generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial
statements, and the reported amounts of revenue and expenses during the reporting period. Actual results could differ from those estimates.

Cash and Cash Equivalents - Cash and cash equivalents represent cash and highly liquid investments purchased within three
months of the maturity date and consist primarily of mutual and money market funds.

Investments - The Company
invests available cash primarily in mutual and money market funds, bank certificates of deposit and investment-grade commercial paper, corporate notes, and government securities. All investments are classified as available-for-sale and are carried
at fair market value with unrealized gains and losses recorded in accumulated other comprehensive (loss) income. For purposes of determining realized gains and losses, the cost of securities sold is based on specific identification.

Deferred Offering Costs - Costs incurred in connection with an equity offering are deferred and, upon completion of the
equity offering, are applied against the proceeds from the offering.

Deferred Financing Costs - Costs incurred
in connection with debt offerings are deferred (and included in prepaid expenses and other current assets and other long-term assets on the balance sheet) and amortized as interest expense over the term of the related debt using the effective
interest method. The amortization expense is included in interest expense in the statements of operations.

Equipment
and Leasehold Improvements - Equipment and leasehold improvements are recorded at cost and are depreciated using the straight-line method over the following estimated useful lives of the assets: computer equipmentthree years;
laboratory and office equipmentseven years; and leasehold improvementsthe lesser of the estimated useful life of the asset or the lease term. Expenditures for maintenance and repairs are expensed as incurred. Capital expenditures which
improve and extend the life of the related assets are capitalized.

Intangible Assets -Intangible assets are
recorded at cost and are amortized on a straight-line basis over the estimated useful life. The estimated useful life is determined based upon a review of several factors including the nature of the asset, its expected use, length of the agreement
and the period over which benefits are expected to be received from the use of the asset.

Impairment of Long-Lived
Assets - The Company continually evaluates whether events or circumstances have occurred that indicate the estimated remaining useful lives of long-lived assets may require revision or that the carrying value of these assets may be impaired.
To determine whether assets have been impaired, the estimated undiscounted future cash flows for the estimated remaining useful life of the respective assets are compared to the carrying value. To the extent that the undiscounted future cash flows
are less than the carrying value, a new fair value of the asset is required to be determined. If such fair value is less than the current carrying value, the asset is written down to its estimated fair value.

Fair Value of Financial Instruments-The Company categorizes its financial assets based on the priority of
the inputs to the valuation technique into a three-level fair value hierarchy as set forth below. Except for the Companys debt with its lender (See Note 5), the Company does not have any financial liabilities that are required to be
measured at fair value on a recurring basis. If the inputs used to measure the financial instruments fall within different levels of the hierarchy, the categorization is based on the lowest level input that is significant to the fair value
measurement of the instrument.

Financial assets recorded on the balance sheets are categorized as follows:



| |  |  | Level 1  Financial assets whose values are based on unadjusted quoted prices for identical assets or liabilities in an active market which the
Company has the ability to access at the measurement date (examples include active exchange-traded equity securities and most U.S. government and agency securities).
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | Level 2  Financial assets whose values are based on quoted market prices in markets where trading occurs infrequently or whose values are based
on quoted prices of instruments with similar attributes in active markets.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Level 3  Financial assets whose values are based on prices or valuation techniques that require inputs that are both unobservable and significant
to the overall fair value measurement. These inputs reflect managements own assumptions about the assumptions a market participant would use in pricing the asset.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

As of June 30, 2010 and September 30, 2009, the Company did not have any Level 2 or 3 financial assets and the Companys
Level 1 financial assets were as follows:



|                                                                |  |                |         |                   |   |       
|--------------------------------------------------------------- |  | -------------- | ------- | ----------------- | - | ------
|                                                                |  | Level 1       
|                                                                |  | June 30,2010   |         | September 30,2009
|                                                                |  | (in thousands)
|Money Market Funds                                              |  | $              | 4,855   |                   | $ | 16,838
|Mutual Funds (invested in short-term U.S. Treasury Obligations) |  |                | 139,519 |                   |   | 41,570
|Certificate of Deposit                                          |  |                | 100     |                   |   | 100   
|                                                                |  |                |         |                   |   |       
|Total                                                           |  | $              | 144,474 |                   | $ | 58,508
|                                                                |  |                |         |                   |   |       

The Certificate of Deposit included above as of
June 30, 2010 and September 30, 2009 is for a letter of credit in place to support a performance bond required to ensure payment of import duties on supplies used in the Companys development programs, and is classified as Restricted
Cash on the balance sheet as of June 30, 2010 and September 30, 2009.

Concentrations of Credit Risk,
Suppliers, and Revenues - The Companys financial instruments that potentially subject it to concentrations of credit risk are cash and cash equivalents and investments. The Company invests cash that is not currently being used in
operations in accordance with its investment policy. The policy allows for the purchase of low-risk, investment grade debt securities issued by the United States government and very highly-rated banks and corporations, subject to certain
concentration limits. The policy allows for maturities that are not longer than two years for individual securities and an average of one year for the portfolio as a whole.

The Company relies on certain materials used in its development process, some of which are procured from a single source. The failure of
a supplier, including a subcontractor, to deliver on schedule could delay or interrupt the development process and thereby adversely affect the Companys operating results.

During the three and nine months ended June 30, 2010 and 2009, the Company derived all of its revenues from one customer (See
Note 4).

Revenue Recognition - The Company recognizes revenues when all of the following four criteria are
present: persuasive evidence of an arrangement exists; delivery has occurred or services have been rendered; the fee is fixed or determinable; and collectability is reasonably assured. For arrangements that involve the delivery or performance of
multiple products, services and/or rights to use assets, the elements are divided into separate units of accounting if certain criteria are met, including whether the delivered element has stand-alone value to the collaborator and whether there is
objective and reliable evidence of the fair value of the undelivered obligation(s). The consideration received is allocated among the separate units either on the basis of each units fair value or using the residual method and the applicable
revenue recognition criteria is applied to each of the separate units.



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The Companys revenues are primarily related to its collaboration agreement with Roche.
This agreement provides for various types of payments to the Company, including non-refundable upfront license fees, research and/or development payments, and milestone payments.

Where the Company has continuing performance obligations under the terms of a collaborative arrangement, non-refundable upfront license
payments received upon contract signing are recorded as deferred revenue and recognized as revenue as the related activities are performed. The period over which these activities are to be performed is based upon managements estimate of the
development period. Changes in managements estimate could change the period over which revenue is recognized. Research and/or development payments are recognized as revenues as the related research and/or development activities are performed
and when the Company has no continuing performance obligations related to the research and development payment received.

The
Company recognizes revenue from milestone payments when earned, provided that (i) the milestone event is substantive and its achievability was not reasonably assured at the inception of the agreement and (ii) the Company does not have
ongoing performance obligations related to the achievement of the milestone earned. Milestone payments are considered substantive if all of the following conditions are met: the milestone payment is non-refundable; achievement of the milestone was
not reasonably assured at the inception of the arrangement; substantive effort is involved to achieve the milestone; and the amount of the milestone appears reasonable in relation to the effort expended, the other milestones in the arrangement and
the related risk associated with the achievement of the milestone. Any amounts received under the agreements in advance of performance, if deemed substantive, are recorded as deferred revenue and recognized as revenue as the Company completes its
performance obligations.

Where the Company has no continuing involvement under a collaborative arrangement, the Company
records nonrefundable license fee revenues when the Company has the contractual right to receive the payment, in accordance with the terms of the license agreement, and records milestones upon appropriate notification to the Company of achievement
of the milestones by the collaborative partner.

Deferred revenue associated with a non-refundable payment received under a
collaborative agreement that is terminated prior to its completion results in an immediate recognition of the deferred revenue.

Research and Development Expenses - Research and development expenses consist primarily of salaries and related personnel
expenses, fees paid to external service providers, costs of preclinical studies and clinical trials, drug and laboratory supplies, costs for facilities and equipment, and the costs of intangibles that are purchased from others for use in research
and development activities, such as in-licensed product candidates, that have no alternative future uses. Research and development expenses are included in operating expenses when incurred. Reimbursements received from the Companys
collaborator(s) for third-party research and development expenses incurred by the Company on their behalf are recorded as a contra-expense. Amounts due from collaborators for reimbursement of research and development expenses are recorded on the
balance sheets as Amounts due from collaboration partner.

Nonrefundable advance payments for goods or services
that will be used or rendered for future research and development activities are deferred and capitalized. Such amounts are then recognized as an expense as the related goods are delivered or the services are performed, or when the goods or services
are no longer expected to be provided.

Stock-Based Compensation - The Company recognizes stock compensation
expense for awards of equity instruments to employees and directors based on the grant-date fair value of those awards (with limited exceptions). The grant-date fair value of the award is recognized as compensation expense on a straight-line basis
over the requisite service period. Equity instruments granted to consultants are periodically valued and recorded as stock compensation expense as the equity instrument vests.

Stock-based compensation expense is included in both research and development expenses and in general and administrative expenses in the
statements of operations. Since the Companys stock was not publicly traded prior to April 27, 2007, the expected volatility was calculated for each equity award granted based on the peer method. The Company identified
companies that trade publicly within the pharmaceutical industry that have similar SIC codes, employee count and revenues. Prior to October 1, 2006, the Company had chosen the weekly high price volatility for these companies for a period of
five years. Subsequent to October 1, 2006, the Company has used the weekly high price for these companies for a period of six years to coincide with the expected term.



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Income Taxes - The Company accounts for income taxes under the asset and
liability method. The Company provides deferred tax assets and liabilities for the expected future tax consequences of temporary differences between the Companys financial statement carrying amounts and the tax bases of assets and liabilities
using enacted tax rates expected to be in effect in the years in which the differences are expected to reverse. A valuation allowance is provided to reduce the deferred tax assets to the amount that is expected to be realized.

On October 1, 2007, the Company adopted a new comprehensive model for how it recognizes, measures, presents, and discloses in its
financial statements uncertain tax positions that the Company has taken or expects to take on a tax return (including a decision whether to file or not to file a return in a particular jurisdiction). Under this new comprehensive model, the financial
statements reflect expected future tax consequences of such positions presuming the taxing authorities full knowledge of the position and all relevant facts.

As a result of adopting this new comprehensive model, there were no changes to the Companys deferred tax assets as of
October 1, 2007. The total amount of unrecognized tax benefits at October 1, 2007 was $126,000, all of which would favorably impact the Companys effective tax rate if recognized. Since the unrecognized tax benefit has not been
utilized on the Companys tax returns, there is no liability recorded on the balance sheets. The Company does not have any interest or penalties accrued related to tax positions at adoption. In the event the Company determines that accrual of
interest or penalties are necessary in the future, the amount will be presented as a component of income taxes.

Net
Income (Loss) Per Common Share - Basic net income (loss) per common share is calculated by dividing net income (loss) by the weighted average number of common shares outstanding during the period. Diluted net income (loss) per common share
is calculated by dividing net income (loss) by the weighted average number of common shares and other dilutive securities outstanding during the period. Dilutive potential common shares resulting from the assumed exercise of outstanding stock
options and warrants are determined based on the treasury stock method.



|                                                                                             |  |                                         |         |   |                                         |   |        |      |  |   |         |   |  |   |         |  
|-------------------------------------------------------------------------------------------- |  | --------------------------------------- | ------- | - | --------------------------------------- | - | ------ | ---- |  | - | ------- | - |  | - | ------- | -
|                                                                                             |  | Three Months EndedJune 30,              |         |   | Nine Months EndedJune 30,               |  
|                                                                                             |  | 2010                                    |         |   | 2009                                    |   |        | 2010 |  |   | 2009    |  
|                                                                                             |  | (In thousands, exceptper share amounts) |         |   | (In thousands, exceptper share amounts) |  
|Numerator:                                                                                   |  |                                         |         |   |                                         |   |        |      |  |   |         |   |  |   |         |  
|Net loss                                                                                     |  | $                                       | (16,020 | ) |                                         | $ | (6,949 | )    |  | $ | (45,951 | ) |  | $ | (40,697 | )
|                                                                                             |  |                                         |         |   |                                         |   |        |      |  |   |         |   |  |   |         |  
|Denominator:                                                                                 |  |                                         |         |   |                                         |   |        |      |  |   |         |   |  |   |         |  
|Weighted average common shares outstanding used in calculation of basic net loss per share   |  |                                         | 32,001  |   |                                         |   | 28,121 |      |  |   | 29,932  |   |  |   | 25,907  |  
|Effect of dilutive securities:                                                               |  |                                         |         |   |                                         |   |        |      |  |   |         |   |  |   |         |  
|Common stock options                                                                         |  |                                         |        |   |                                         |   |       |      |  |   |        |   |  |   |        |  
|Common stock warrants                                                                        |  |                                         |        |   |                                         |   |       |      |  |   |        |   |  |   |        |  
|                                                                                             |  |                                         |         |   |                                         |   |        |      |  |   |         |   |  |   |         |  
|Weighted average common shares outstanding used in calculation of diluted net loss per share |  |                                         | 32,001  |   |                                         |   | 28,121 |      |  |   | 29,932  |   |  |   | 25,907  |  
|                                                                                             |  |                                         |         |   |                                         |   |        |      |  |   |         |   |  |   |         |  
|                                                                                             |  |                                         |         |  
|Net loss per share: basic and diluted                                                        |  | $                                       | (0.50   | ) |                                         | $ | (0.25  | )    |  | $ | (1.54   | ) |  | $ | (1.57   | )
|                                                                                             |  |                                         |         |   |                                         |   |        |      |  |   |         |   |  |   |         |  

The following table summarizes the securities outstanding at the end of each period with the potential to
become common stock that have been excluded from the computation of diluted net income (loss) per share, as their effect would have been anti-dilutive.



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|                                 |  |                |  |      
|-------------------------------- |  | -------------- |  | -----
|                                 |  | As of June 30,
|                                 |  | 2010           |  | 2009 
|                                 |  | (In thousands)
|                                 |  |               
|Options to purchase common stock |  | 2,871          |  | 2,689
|Common stock warrants            |  | 127            |  | 127  
|                                 |  |                |  |      
|Total                            |  | 2,998          |  | 2,816
|                                 |  |                |  |      

Segment Reporting - Operating segments
are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker, or decision-making group, in making decisions regarding resource allocation and
assessing performance. The Company, which uses financial information in determining how to allocate resources and assess performance, has determined that it operates in one segment, which focuses on developing nucleoside/tide analog drugs for the
treatment of viral infections.

Recently Issued Accounting Pronouncements- In October 2009, the
FASB issued ASU No. 2009-13, Multiple-Deliverable Revenue Arrangements. This ASU provides guidance on accounting for multiple-deliverable revenue arrangements that provides principles and application guidance on whether multiple
deliverables exist, and how the arrangement should be separated and the consideration allocated. This guidance requires an entity to allocate revenue in an arrangement using estimated selling prices of deliverables if a vendor does not have
vendor-specific objective evidence or third-party evidence of selling price. The update eliminates the use of the residual method and requires an entity to allocate revenue using the relative selling price method and also significantly expands the
disclosure requirements for multiple-deliverable revenue arrangements. This guidance should be applied on a prospective basis for revenue arrangements entered into or materially modified in fiscal years beginning on or after June 15, 2010, with
earlier application permitted. The Company is currently evaluating the impact, if any, of adopting this guidance on its financial statements.

In April 2010, the FASB issued ASU No. 2010-17, Revenue Recognition  Milestone Method. This ASU provides guidance
on the criteria that should be met for determining whether the milestone method of revenue recognition is appropriate. Under the milestone method of revenue recognition, consideration that is contingent upon achievement of a milestone in its
entirety can be recognized as revenue in the period in which the milestone is achieved only if the milestone meets all criteria to be considered substantive. This standard provides the criteria to be met for a milestone to be considered substantive
which includes that: a) performance consideration earned by achieving the milestone be commensurate with either performance to achieve the milestone or the enhancement of the value of the item delivered as a result of a specific outcome resulting
from performance to achieve the milestone; and b) relate to past performance and be reasonable relative to all deliverables and payment terms in the arrangement. This standard is effective on a prospective basis for milestones in fiscal years
beginning on or after June 15, 2010. Although we are still evaluating the impact of this standard, we do not expect its adoption to have a material impact on our financial position or the results of our operations.

3. ACCRUED EXPENSES

Accrued expenses consisted of the following:



|                                |  |                |       |                    |   |      
|------------------------------- |  | -------------- | ----- | ------------------ | - | -----
|                                |  | As of          |       | As of             
|                                |  | June 30, 2010  |       | September 30, 2009
|                                |  | (In thousands)
|Accrued clinical trial expenses |  | $              | 776   |                    | $ | 4,274
|Accrued compensation            |  |                | 1,342 |                    |   | 1,623
|Accrued legal fees              |  |                | 1,725 |                    |   | 1,165
|Other accrued expenses          |  |                | 903   |                    |   | 613  
|                                |  |                |       |                    |   |      
|                                |  | $              | 4,746 |                    | $ | 7,675
|                                |  |                |       |                    |   |      



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4. CONTRACT REVENUE AGREEMENTS

The following is a reconciliation between cash payments received and receivable under contract revenue agreements and contract revenues
reported:



|                         |  |                            |     |                           |   |        |  |      |     |  |   |       
|------------------------ |  | -------------------------- | --- | ------------------------- | - | ------ |  | ---- | --- |  | - | ------
|                         |  | Three Months EndedJune 30, |     | Nine Months EndedJune 30,
|                         |  | 2010                       |     | 2009                      |   | 2010   |  | 2009
|                         |  | (In thousands)             |     | (In thousands)           
|Cash received/receivable |  | $                          | 3   |                           | $ | 10,037 |  | $    | 30  |  | $ | 11,475
|Deferred                 |  |                            |    |                           |   |       |  |      |    |  |   |      
|Amortization             |  |                            | 246 |                           |   | 464    |  |      | 739 |  |   | 1,393 
|                         |  |                            |     |                           |   |        |  |      |     |  |   |       
|Revenues                 |  | $                          | 249 |                           | $ | 10,501 |  | $    | 769 |  | $ | 12,868
|                         |  |                            |     |                           |   |        |  |      |     |  |   |       

The Company recorded revenues from the collaboration
agreement with Roche, comprising 100% of total revenues during the three and nine months ended June 30, 2010 and 2009. Revenues during each period reflect amortization of up-front and subsequent collaborative and license payments received from
Roche previously recorded as deferred revenue. Revenues during the three and nine months ended June 30, 2009 also include a $10.0 million milestone payment received from Roche for initiating a Phase 2b study of RG7128. Revenues during the nine
months ended June 30, 2009 also include $1.4 million of research and development payments from Roche for activities related to holding and maintaining the Investigational New Drug (IND) application for RG7128.

Roche - In October 2004, the Company entered into a collaboration and license agreement with Roche to develop PSI-6130 and
PSI-6130 prodrugs (including RG7128) for treating chronic HCV infection, and to discover chemically related nucleoside polymerase inhibitors pursuant to a research collaboration. The research collaboration ended in December 2006 with no additional
rights being conferred upon Roche. The Company granted Roche worldwide rights, excluding Latin America and Korea, to PSI-6130 and its prodrugs (including RG7128). Roche paid the Company an up-front payment of $8.0 million in 2004 and agreed to pay
future research and development costs. The up-front payment has been recorded as deferred revenue and is being amortized over the estimated development period. The portion of the above payments recorded as deferred revenue on the Companys
balance sheets as of June 30, 2010 and September 30, 2009 was approximately $3.2 million and $3.9 million, respectively. Roche is also required to make certain future payments to the Company for RG7128 upon the achievement of predefined
development and marketing milestones in Roches territories. In addition, the Company will receive royalties paid as a percentage of total annual net product sales, if any, in Roches territories, and the Company will be entitled to
receive one time performance payments should net sales from the product exceed specified thresholds.

The Company retained
certain co-promotion rights in the United States. The Company will be required to pay Roche royalties on net product sales, if any, in the territories the Company has retained. Prior to the transfer of the IND for RG7128 to Roche, which occurred
during December 2008, Roche funded and the Company was responsible for preclinical work, the IND submission, and the initial clinical trial, while Roche managed other preclinical studies and clinical development. Roche reimbursed the Company
approximately $3 thousand and $0.3 million during the three months ended June 30, 2010 and 2009, and $42 thousand and $0.8 million during the nine months ended June 30, 2010 and 2009, respectively, under this agreement. Roche will continue
to fund all of the expenses of, and be responsible for, other preclinical studies and future clinical development of RG7128 in the territories licensed to Roche. Roche and the Company will continue to jointly oversee all development and marketing
activities of RG7128 in the territories licensed to Roche.

The agreement will terminate once there are no longer any royalty
or payment obligations. Additionally, Roche may terminate the agreement in whole or in part by providing six months written notice to the Company. Otherwise, either party may terminate the agreement in whole or in part in connection with a
material breach of the agreement by the other party that is not timely cured. In the event of termination, Roche must assign or transfer to the Company all regulatory filings, trademarks, patents, and preclinical and clinical data related to this
collaboration.



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5. DEBT

On September 30, 2007, the Company entered into a Loan Agreement that allowed the Company to borrow up to $30.0 million in $10.0
million increments (Loan Agreement). The Company borrowed the first and second $10.0 million increments by signing two Secured Promissory Notes (Notes A and B) on October 5, 2007 and March 28, 2008, respectively.
Notes A and B bear interest at 12%. On December 12, 2008, the Company amended the Loan Agreement and borrowed $3.3 million by signing a Secured Promissory Note (Note C). Note C bears interest at 12.5%. Notes A, B and C are to be
repaid over a 45-month period with the first 15 monthly payments representing interest only followed by 30 equal monthly payments of principal and interest. The principal monthly repayments on each of the following notes begin and end as follows:



|       |  |                |  |                
|------ |  | -------------- |  | ---------------
|Note   |  | Begin          |  | End            
|       |  |               
|Note A |  | March 1, 2009  |  | August 1, 2011 
|Note B |  | August 1, 2009 |  | January 1, 2012
|Note C |  | May 1, 2010    |  | October 1, 2012

Prepayment of
the loans made pursuant to the Loan Agreement is subject to penalty and substantially all of the Companys tangible and intangible assets (except for intellectual property) are pledged as collateral for the Loan Agreement. Future total
principal repayments of the three Notes amount to $1.5 million in fiscal 2010, $9.5 million in fiscal 2011, $3.0 million in fiscal 2012, and $0.1 million in fiscal 2013. There are no additional borrowings available under the Loan Agreement.

Under the Loan Agreement, the Company agreed that in the event its market capitalization is below $90.0 million for 15
consecutive days in which the principal market for its common stock is open for trading to the public, the Company will be required to repay 50% of the then outstanding principal balance of the loans. The Company further agreed that in the event its
market capitalization is below $40.0 million for 15 consecutive days in which the principal market for its common stock is open for trading to the public, the Company will be required to repay all of the then outstanding principal balance of the
loans.

In conjunction with entering into the Loan Agreement, the Company granted warrants to the lender to purchase shares of
the Companys common stock (See Note 7). Since these warrants were granted in conjunction with entering into the Loan Agreement and with the intention of executing promissory notes, the relative fair value of the warrant was recorded as equity
and deferred interest as the warrants became exercisable and the deferred financing costs and debt discount are being amortized over the term of the promissory notes using the effective interest method.

6. STOCK COMPENSATION

In 1998, the Company adopted the 1998 Stock Plan, which was subsequently amended (hereinafter referred to as the 1998 Plan, as
amended). In 2007, the Company adopted the 2007 Equity Incentive Plan (2007 Plan). Upon the adoption of the 2007 Plan, no additional awards will be issued under the 1998 Plan, as amended, and the shares remaining for future
issuance under the 1998 Stock Plan, as amended, were transferred to the 2007 Plan. The purpose of these plans is to provide an incentive to officers, directors, employees, independent contractors, and to other persons who provide significant
services to the Company. A maximum of 5,683,396 shares of the Companys common stock are authorized for issuance under the 2007 Plan, as amended and the 1998 Stock Plan, as amended. Issuances can be in the form of stock options, stock
appreciation rights, restricted stock, deferred stock, restricted stock units, performance shares, phantom stock, and similar types of stock awards as well as cash awards. Stock options granted under the 2007 Plan, as amended may be either
incentive stock options, as defined under Section 422 of the Internal Revenue Code (Code) or nonstatutory stock options and shall be granted at per share exercise prices equal to the fair value of the shares on the dates
of grant. The 2007 Plan, as amended, will terminate in fiscal 2017 unless it is extended or terminated earlier pursuant to its terms. As of June 30, 2010, 712,346 shares were available for future issuance under the 2007 Plan, as amended.



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Stock Options - The assumptions used and weighted-average information for
employee and director grants for the three and nine months ended June 30, 2010 and 2009 are as follows:



|                                               |  |                    |       |                   |          |   |      |   |       |      |  |   |       |  
|---------------------------------------------- |  | ------------------ | ----- | ----------------- | -------- | - | ---- | - | ----- | ---- |  | - | ----- | -
|                                               |  | Three Months Ended |       | Nine Months Ended |         
|                                               |  | June 30,           |       | June 30,          |         
|                                               |  | 2010               |       |                   | 2009 (1) |   | 2010 |   |       | 2009 | 
|Risk free interest rate                        |  |                    | 2.93  | %                 |          |  |      |   | 2.91  | %    |  |   | 3.19  | %
|Expected dividend yield                        |  |                    | 0.0   | %                 |          |  |      |   | 0.0   | %    |  |   | 0.0   | %
|Expected lives (years)                         |  |                    | 6.11  |                   |          |  |      |   | 6.00  |      |  |   | 5.98  |  
|Expected volatility                            |  |                    | 68.28 | %                 |          |  |      |   | 64.26 | %    |  |   | 54.39 | %
|Weighted-average fair value of options granted |  | $                  | 21.06 |                   |          |  |      | $ | 13.17 |      |  | $ | 9.97  |  



|(1) | No stock options were granted during the three months ended June 30, 2009.
|--- | --------------------------------------------------------------------------

Generally, stock options granted under these plans have a contractual life of ten years and vest pro rata over three or four year terms.
A summary of the Companys stock option activity during the nine months ended June 30, 2010 is as follows:



|                                            |  |           |   |  |                  |      
|------------------------------------------- |  | --------- | - |  | ---------------- | -----
|                                            |  | Number of |   |  | Weighted Average
|                                            |  | Shares    |   |  | Exercise Price  
|Outstanding - September 30, 2009            |  | 2,548,700 |   |  | $                | 10.26
|Granted (unaudited)                         |  | 566,691   |   |  | $                | 21.65
|Exercised (unaudited)                       |  | (50,571   | ) |  | $                | 5.34 
|Forfeited (unaudited)                       |  | (6,409    | ) |  | $                | 21.97
|                                            |  |           |   |  |                  |      
|Outstanding - December 31, 2009 (unaudited) |  | 3,058,411 |   |  | $                | 12.43
|Granted (unaudited)                         |  | 5,000     |   |  | $                | 28.95
|Exercised (unaudited)                       |  | (83,638   | ) |  | $                | 8.90 
|Forfeited (unaudited)                       |  | (56,809   | ) |  | $                | 18.73
|                                            |  |           |   |  |                  |      
|Outstanding - March 31, 2010 (unaudited)    |  | 2,922,964 |   |  | $                | 12.44
|Granted (unaudited)                         |  | 1,800     |   |  | $                | 33.10
|Exercised (unaudited)                       |  | (43,831   | ) |  | $                | 9.86 
|Forfeited (unaudited)                       |  | (10,171   | ) |  | $                | 17.57
|                                            |  |           |   |  |                  |      
|Outstanding - June 30, 2010 (unaudited)     |  | 2,870,762 |   |  | $                | 12.47
|Exercisable - September 30, 2009            |  | 1,481,788 |   |  | $                | 6.97 
|                                            |  |           |   |  |                  |      
|Exercisable - December 31, 2009 (unaudited) |  | 1,672,754 |   |  | $                | 8.34 
|                                            |  |           |   |  |                  |      
|Exercisable - March 31, 2010 (unaudited)    |  | 1,703,201 |   |  | $                | 8.61 
|                                            |  |           |   |  |                  |      
|Exercisable - June 30, 2010 (unaudited)     |  | 1,762,296 |   |  | $                | 8.85 
|                                            |  |           |   |  |                  |      

The range of exercise prices of stock options outstanding at June 30, 2010 was $3.00 to
$33.10. The weighted average remaining contractual life of stock options outstanding at June 30, 2010 was 7.09 years. The total intrinsic value of options exercised during the nine months ended June 30, 2010 was $2,962,238. The Company
recognized compensation expense of $1,160,216 and $959,040 during the three months ended June 30, 2010 and 2009, and $4,059,496 and $3,320,463 during the nine months ended June 30, 2010 and 2009, respectively, related to stock options
issued to non-employees and employees. As of June 30, 2010 and September 30, 2009, $9,189,601 and $6,937,089, respectively, of deferred stock-based compensation expense related to non-employee and employee stock options remained
unamortized. The unamortized amount of $9,189,601 as of June 30, 2010 has a weighted-average period of approximately 1.37 years to be recognized.



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|                                |  |                                 |  |                                                    |  |                              |       |                  |         |                              |   |      
|------------------------------- |  | ------------------------------- |  | -------------------------------------------------- |  | ---------------------------- | ----- | ---------------- | ------- | ---------------------------- | - | -----
|Outstanding as of June 30, 2010 |  | Exercisable as of June 30, 2010
|Number ofOptions                |  | ExercisePrice                   |  | WeightedAverageRemainingContractualLife (in Years) |  | WeightedAverageExercisePrice |       | Number ofOptions |         | WeightedAverageExercisePrice
|                                |  |                                 |  |                                                    | 
|990,318                         |  | 3.00 - 4.49                     |  | 5.20                                               |  | $                            | 3.43  |                  | 940,919 |                              | $ | 3.39 
|6,500                           |  | 4.50 - 5.99                     |  | 6.75                                               |  | $                            | 5.58  |                  | 4,041   |                              | $ | 5.61 
|27,268                          |  | 6.00 - 7.49                     |  | 1.73                                               |  | $                            | 6.55  |                  | 27,268  |                              | $ | 6.55 
|86,666                          |  | 7.50 -10.49                     |  | 6.86                                               |  | $                            | 8.88  |                  | 81,666  |                              | $ | 8.91 
|618,266                         |  | 10.50 -15.00                    |  | 7.33                                               |  | $                            | 13.66 |                  | 372,066 |                              | $ | 13.66
|1,133,944                       |  | 15.01 -29.99                    |  | 8.74                                               |  | $                            | 20.05 |                  | 335,773 |                              | $ | 19.00
|7,800                           |  | 30.00 -33.10                    |  | 9.48                                               |  | $                            | 30.30 |                  | 563     |                              | $ | 32.00

As of June 30,
2010, after considering estimated forfeitures, there were 2,764,051 options outstanding that were either vested or expected to vest in the future, of which 1,762,296 options were currently exercisable, with weighted average exercise prices of $12.26
and $8.85 per share, aggregate intrinsic values of $41,703,363 and $32,583,492 and weighted average remaining contractual terms of 7.04 and 6.23 years, respectively.

Restricted Stock - Restricted stock has been issued to the Companys non-employee directors and to
consultant(s). Restricted stock issued to non-employee directors prior to fiscal 2010 vested no later than one year from the date of issuance, as long as the director remained in continuous service to the Company as of the vest date. Restricted
stock issued to non-employee directors subsequent to fiscal 2009 vests 50% on the first anniversary of the date of grant, 25% on the second anniversary, and 25% on the third anniversary, provided that the director is and has remained in continuous
service to the Company as a director as of such anniversary. Restricted stock issued to a consultant vests equally on a quarterly basis over four years.

With regard to restricted stock granted to non-employee directors, the fair value of the restricted stock issued was determined using the
closing price of the Companys common stock as reported on the Global Market of The NASDAQ Stock Market LLC (NASDAQ) on the date of grant and is recognized as stock-based compensation expense as the shares vest over the vesting
period. With regard to the restricted stock granted to the consultant, stock-based compensation expense equal to the fair value of the restricted shares that vest is recorded on a quarterly basis over the vesting period of four years. The fair value
of each of the restricted shares that vest is equal to the fair value of a share of the Companys common stock as of each vesting date.

A summary of the Companys restricted stock activity during the nine months ended June 30, 2010 is as follows:



|                                            |  |                
|------------------------------------------- |  | ---------------
|                                            |  | Number ofShares
|Outstanding - September 30, 2009            |  | 54,666         
|Granted (unaudited)                         |  |               
|Forfeited (unaudited)                       |  |               
|                                            |  |                
|Outstanding - December 31, 2009 (unaudited) |  | 54,666         
|Granted (unaudited)                         |  | 12,000         
|Forfeited (unaudited)                       |  |               
|                                            |  |                
|Outstanding - March 31, 2010 (unaudited)    |  | 66,666         
|Granted (unaudited)                         |  |               
|Forfeited (unaudited)                       |  |               
|                                            |  |                
|Outstanding - June 30, 2010 (unaudited)     |  | 66,666         
|                                            |  |                

During March 2010, the Company issued a total of
12,000 shares of restricted stock to its non-employee directors. As of June 30, 2010, holders were vested in 51,332 of the 66,666 restricted shares outstanding, leaving a total of 15,334 restricted shares unvested as of quarter end. The
weighted average fair value of the shares granted in fiscal 2010 was $29.01 per share.



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The Company recognized compensation expense of $233,857 during the nine months ended
June 30, 2010 related to restricted stock issued to its non-employee directors and to the consultant. Unrecognized compensation expense for the restricted shares granted to the non-employee directors was $298,525 at June 30, 2010. This
amount will be recognized over the remaining vesting period of the restricted shares.

7. STOCKHOLDERS EQUITY AND WARRANTS

Common Stock - As of June 30, 2010, the Company had 100,000,000 shares of common stock authorized with
a par value of $0.001 per share and the Company had reserved 2,870,762 shares of common stock for issuance upon the exercise of outstanding common stock options. Also, 712,346 shares of the Companys common stock were reserved for future grants
of stock options (or other similar equity instruments) under the Companys 2007 Plan, as amended, as of June 30, 2010. In addition, 127,248 shares of the Companys common stock were reserved for future exercise of outstanding warrants
as of June 30, 2010.

On May 19, 2010, the Company completed an underwritten public offering of 3,680,000 shares of
the Companys common stock (which included the underwriters exercise in full of its over-allotment option) for a price to the public of $29.00 per share. The underwriter purchased the shares from the Company at a price of $27.55 per
share, pursuant to the underwriting agreement. The net proceeds from the sale of the shares, after deducting the underwriters discount and offering expenses, were $101.2 million.

In addition, on February 2, 2010, the Company completed an underwritten public offering of 1,830,400 shares of the Companys
common stock (which included the underwriters exercise in full of its over-allotment option) for a price to the public of $18.75 per share. The underwriter purchased the shares from the Company at a price of $18.00 per share, pursuant to the
underwriting agreement. The net proceeds from the sale of the shares, after deducting the underwriters discount and offering expenses, were $32.7 million.

Initial Public Offering-On May 2, 2007, the Company completed an initial public offering
(IPO) of 5,050,000 shares of its common stock (including the underwriters exercise of a portion of their over-allotment option) at a public offering price of $9.00 per share. Net cash proceeds from the IPO were $40.7 million after
deducting the underwriters discount and offering expenses paid during fiscal 2007.

Warrants - In
conjunction with entering into a Loan Agreement and with executing three secured promissory notes (See Note 5), the Company granted warrants to the lender to purchase 127,248 shares of the Companys common stock. The warrants expire seven years
from the date of grant (or upon a change of control as defined in the Loan Agreement) as follows: 66,390 expire on September 30, 2014, 49,793 expire on March 28, 2015, and 11,065 expire on December 12, 2015.

8. INCOME TAXES

There
was no income tax expense during the three and nine months ended June 30, 2010 and 2009. The Companys effective tax rate for the three and nine months ended June 30, 2010 and 2009 was 0% due to uncertainties related to the
realizability of the deferred tax assets as a result of the Companys history of operating losses. The net deferred tax asset as of June 30, 2010 remains fully offset by a valuation allowance since it is more likely than not that such tax
benefits will not be realized.

As of September 30, 2009, the Company had United States federal net operating loss
carryforwards of approximately $144.9 million available to offset future taxable income, if any. Of the federal net operating losses, $10.5 million was generated from windfall tax benefit stock option deductions. The tax benefit of this portion of
the net operating loss will be accounted for directly to equity as additional paid in capital as the stock option related losses are utilized. As of September 30, 2009, the Company also had research and development tax credits of approximately
$138,159 available to offset future tax liabilities. The loss carryovers and the research and development tax credits expire over a period of 2020 to 2029.



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As of October 1, 2007, the Companys unrecognized tax benefits were $126,000 and
have not significantly changed as of June 30, 2010. The Company does not expect any significant changes to the unrecognized tax benefits within 12 months of the reporting date.

The Internal Revenue Service (IRS) could challenge tax positions taken by the Company for the periods for which there are
open tax years. The Company is open to challenge for the periods of 2004-2009 from federal and state jurisdictions.

Under
Section 382 of the Code, utilization of the net operating loss and research and development tax credit carryforwards may be subject to a limitation if a change in ownership of the Company, as defined in the Code, occurred previously or could
occur in the future. The Company completed a Section 382 analysis regarding limitation of its net operating loss and research and development credit carryforwards that covered the period three years prior to its IPO on May 2, 2007 through
its follow-on public offering of its common stock on February 5, 2009, and concluded that a change in control occurred at the Company during the quarter ended September 30, 2008. This change in control limits the future use of the
Companys net operating loss and research and development credit carryforwards from fiscal 2008 and prior years. However, based upon the Companys financial projections, it does not believe that this limitation will result in the
expiration of any of these net operating loss and research and development credit carryforwards before they are able to be utilized. Changes in ownership subsequent to this period could lead to a change in the limitation in future years, which could
impact the use of the Companys net operating loss and research and development credit carryforwards generated in the affected years. Any limitation may result in expiration of a portion of the NOL or research and development credit
carryforwards before utilization, which would reduce the Companys gross deferred tax assets. The Company will continue to monitor changes in its ownership and will update its Section 382 analysis when it believes a change in control may
have occurred.

9. COMMITMENTS AND CONTINGENCIES

The Company has entered into an operating lease for office and laboratory space located in Princeton, New Jersey through May 22,
2015. The Company has also entered into an operating lease for office space located in Durham, North Carolina through April 2011.

As of June 30, 2010, minimum future payments under non-cancellable operating leases are as follows:



|                                |  |                    |      
|------------------------------- |  | ------------------ | -----
|                                |  | As ofJune 30, 2010
|                                |  | (In thousands)    
|Fiscal 2010                     |  |                    | 150  
|Fiscal 2011                     |  |                    | 884  
|Fiscal 2012                     |  |                    | 835  
|Fiscal 2013                     |  |                    | 835  
|Fiscal 2014                     |  |                    | 835  
|Thereafter                      |  |                    | 537  
|                                |  |                    |      
|                                | 
|Total minimum payments required |  | $                  | 4,076
|                                |  |                    |      

Under a license agreement with Emory University for
Racivir, the Company agreed to pay Emory University up to an aggregate of $1.0 million in future marketing milestone payments. None of these potential future payments are included in the Companys financial statements, as the payments are
contingent on the achievement of milestones, which it has not yet achieved.



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##### Table of Contents

|ITEM 2. | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
|------- | -------------------------------------------------------------------------------------

The following discussion and analysis should be read together with our condensed financial statements and the related notes to those
condensed financial statements included elsewhere in this Quarterly Report on Form 10-Q.

Overview

We are a clinical-stage pharmaceutical company committed to discovering, developing, and commercializing novel drugs
to treat viral infections. Our primary focus is on the development of nucleoside/tide analogs as oral therapeutics for the treatment of chronic hepatitis C virus (HCV) infection and, secondarily, on the development of
RacivirTMfor the treatment of human immunodeficiency
virus (HIV) infection. Nucleoside/tide analogs are a class of compounds which act as alternative substrates for the viral polymerase, thus inhibiting viral replication. We currently have four clinical-stage product candidates, three of
which we are developing ourselves and one of which we are developing with a strategic partner. We are also advancing a series of preclinical candidates in preparation for clinical development. Our four clinical stage product candidates are:



| |  |  | RG7128, an HCV cytosine nucleoside analog polymerase inhibitor we are developing through a strategic collaboration with F. Hoffmann-La Roche Ltd and
Hoffmann-La Roche Inc. (collectively, Roche). RG7128 recently completed 12 weeks of dosing in a Phase 2b PROPEL clinical trial in combination with
Pegasys® (pegylated interferon) plus
Copegus® (ribavirin), the standard of care for treating HCV (SOC) and is also in a 24 week Phase 2b
clinical trial in combination with SOC. RG7128 is also being evaluated in the INFORM studies, the first series of studies designed to investigate the combination of two oral, direct acting antivirals (DAAs) in the absence of pegylated
interferon and ribavirin. All of these studies are being conducted by Roche;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | PSI-7977, an HCV uracil nucleotide analog polymerase inhibitor that recently completed 28 days of dosing in a Phase 2a clinical trial in combination
with SOC. We are planning for a Phase 2b clinical trial in combination with SOC that we expect to initiate during the fourth calendar quarter of 2010;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | PSI-938, an HCV guanine nucleotide analog polymerase inhibitor that is in a Phase 1 clinical trial; and
| | - |  | -------------------------------------------------------------------------------------------------------



| |  |  | Racivir, for the treatment of HIV in combination with other approved HIV drugs, which has completed a Phase 2 clinical trial.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------

In addition, we are developing PSI-661, an HCV guanine nucleotide analog polymerase inhibitor we nominated as a development
candidate in October 2009. PSI-661 is in preclinical studies required for submission of an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) or equivalent foreign regulatory
application. PSI-938 or PSI-661 could potentially be used in combination with our current nucleoside/tides, RG7128 or PSI-7977, as well as other classes of DAAs. Given the similarities of PSI-938 and PSI-661, our plan is to select one of these
product candidates for later-stage clinical development based upon a review of the early human clinical trial results of both PSI-938 and PSI-661.

We are continuing to research nucleoside/tide analogs (both pyrimidines and purines) with the intention of identifying additional product
candidates that can potentially be used in combination with our nucleoside/tides, RG7128 and PSI-7977, in combination with other classes of DAAs, or with SOC for the treatment of HCV. We have identified proprietary nucleotide prodrugs for oral
administration that are referred to as phosphate prodrugs because they have the ability to deliver the biologically available monophosphate forms of the compounds into infected cells, thus bypassing a rate-limiting step in the metabolic pathway to
the active triphosphate form of the drug. The goal of these efforts is to identify compounds with improved potency, safety, convenience, oral bioavailability, and increased intrahepatic nucleotide triphosphate levels. Certain of these compounds have
demonstrated exceptional in vitro anti-HCV activity, with up to 100 times greater potency than PSI-6130 (of which RG7128 is a prodrug). Early studies in animals indicate that several of these compounds can achieve concentrations of the active
triphosphate form in the liver up to 1000 times higher than PSI-6130 at equivalent doses.



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We are developing PSI-7977, PSI-938, PSI-661, and Racivir ourselves. We have a strategic
collaboration with Roche for the development of PSI-6130 and its prodrugs, including RG7128. Under the collaboration, Roche pays all development costs and provides us with potential income from milestone payments that can be used to fund the
advancement of our proprietary product candidates.

Our Product Candidates

Our research and development programs are primarily focused on discovering and developing drugs that treat HCV and, secondarily, on the
development of Racivir for the treatment of HIV infection. Our product candidates are nucleoside/tide analogs that we believe have potential competitive advantages with respect to safety, efficacy, drug resistance, and/or convenience of dosing as
compared to currently approved drugs and other known investigational agents. The following table summarizes the five product candidates on which we are focusing:



|           |  |                  |  |                                                                                                                                                                                                               |  |                                                                                                                                                                                                               |  |                            
|---------- |  | ---------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ---------------------------
|Indication |  | ProductCandidate |  | Status                                                                                                                                                                                                        |  | Next Expected Milestone(s)                                                                                                                                                                                    |  | CommercializationPartner(s)
|HCV        |  | RG7128           |  | Recently completed 12 week dosing portion in a Phase 2b PROPEL clinical trial and is in a 24 week Phase 2b clinical trial in patients with HCV genotypes 1 and 4. Both
studies are being conducted by Roche |  | Initiate a Phase 2b clinical trial in patients with HCV genotypes 2 and 3 during the first half of calendar year 2011 to be conducted by Roche; initiate Phase 3 studies during 2011
to be conducted by Roche |  | Roche                      
|           |  |                  |  |                                                                                                                                                                                                              
|HCV        |  | PSI-7977         |  | Recently completed 28 days of dosing in a Phase 2a clinical trial and are planning a 12-week Phase 2b clinical trial                                                                                          |  | Initiate a 12-week Phase 2b clinical trial during the fourth calendar quarter of 2010                                                                                                                         |  |                           
|           |  |                  |  |                                                                                                                                                                                                              
|HCV        |  | PSI-938          |  | In a Phase 1 clinical trial                                                                                                                                                                                   |  | Report preliminary results from the Phase 1 clinical trial during the fourth calendar quarter of 2010                                                                                                         |  |                           
|           |  |                  |  |                                                                                                                                                                                                              
|HCV        |  | PSI-661          |  | In IND-enabling preclinical studies                                                                                                                                                                           |  | Submit IND application during the fourth calendar quarter of 2010                                                                                                                                             |  |                           
|           |  |                  |  |                                                                                                                                                                                                              
|HIV        |  | Racivir          |  | Completed Phase 2 clinical trial                                                                                                                                                                              |  | Engage a development partner for a combination drug study                                                                                                                                                     |  |                           

Product
Candidates for the Treatment of HCV

HCV Background

HCV is a leading cause of chronic liver disease and liver transplants. The World Health Organization estimates nearly 180 million
people worldwide, or approximately three percent of the worlds population, are infected with HCV. About 130 million of these individuals are chronic HCV carriers who are at an increased risk of developing liver cirrhosis or liver cancer,
approximately 15 million of whom are in the United States, Europe, and Japan. The Centers for Disease Control and Prevention (CDC) has reported that 4.1 million people in the United States have been infected with HCV, of whom
3.2 million are chronically infected. Of those chronically infected, the majority are undiagnosed and unaware of their HCV infection. Separately, approximately ten percent of diagnosed HCV patients in the United States are treated each year.



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At least six major genotypes of HCV have been identified, each with multiple subtypes.
Genotypes are designated with numbers (genotypes 1-6) and subtypes with letters. HCV genotypes 1, 2, 3, and 4 have a worldwide distribution, but their prevalence varies from one geographic area to another. Genotype 1 and its subtypes (1a and
1b) are the most common genotype globally, accounting for approximately 70% of infections. In the United States, approximately 67% and 33% of all of the genotype 1 HCV infections are subtypes 1a and 1b, respectively. Patients with genotype 2 or 3
represent approximately 25% of the worldwide chronically infected HCV population and the remaining five percent is comprised of genotypes 4 through 6. Worldwide sales of HCV drugs in 2005 were approximately $2.2 billion and are forecasted to reach
more than $8.0 billion in 2015. Historically, sales of HCV drugs increase as new therapies are introduced that improve the sustained virologic response (SVR), defined as the inability to detect HCV RNA in a patients blood six
months after discontinuation of therapy, with a standard polymerase chain reaction (PCR) test, which measures the amount of HCV in the blood.

Limitations of Current HCV Infection Therapy

The current standard of care for treating HCV is a combination of pegylated interferon plus ribavirin. Pegylated
interferon is a modified version of alpha interferon, a protein that occurs naturally in the human body and boosts the immune systems ability to fight viral infections. Roche, our collaboration partner in the development of RG7128, is the
market leader in sales of pegylated interferon and branded ribavirin under the brand names Pegasys® and
Copegus®, respectively.

Patients currently being treated for HCV are given pegylated interferon as a weekly injection, administered together with twice daily
ribavirin tablets. The current SOC, however, has limitations that result in less than optimal SVR rates. Substantial side effects can render treatment intolerable for many patients. For example, SOC-treated patients can have difficulties with
fatigue, bone marrow suppression, anemia, and neuropsychiatric effects. In addition, genotype 1 patients typically receive 48 weeks of SOC, but less than 50% of these patients achieve an SVR, which many physicians and patients consider a low rate of
success. Between 60% and 80% of the genotype 2 and 3 patients treated with SOC for 24 weeks achieve an SVR. The occurrence of side effects combined with the inconvenient treatment regimen can result in many patients not completing therapy.
Furthermore, a majority of individuals with HCV are unable to be treated with interferon due to contraindications, such as advanced liver disease or psychiatric conditions. The less than optimal antiviral efficacy, potential for dose-limiting side
effects (some of which can be serious), contraindications, and inconvenient dosing regimen illustrate the unmet medical need of the currently available SOC. Current therapies may also not directly target the virus, suggesting additional patient
benefit from agents which directly interfere with HCV replication.

Nucleoside/tide Analogs and Other Direct Acting
Antivirals for HCV

HCV has several viral specific enzymes that are essential for its replication, thus providing multiple
opportunities for therapeutic intervention. Many drug developers have focused on three of these enzymes: the protease (NS3) and two polymerases (NS5b and more recently, NS5a) of HCV. The goal of HCV drug
development is to discover and develop molecules that have a high affinity for binding to these enzymes thereby inhibiting enzymatic activity and, in turn, inhibiting viral replication. These compound classes are often referred to as protease
inhibitors and polymerase inhibitors. There are two types of polymerase inhibitors which have different mechanisms of action. Nucleoside/tide analog polymerase inhibitors work by acting as alternative substrates that block the synthesis of HCV RNA,
which is essential for the virus to replicate. The other type of polymerase inhibitor, non-nucleoside polymerase inhibitors, binds directly to the polymerase enzyme, causing a change in its shape. This conformational change inhibits its enzymatic
activity.

Our research efforts focus on blocking HCV replication by discovering and developing nucleoside/tide analog
polymerase inhibitors. A nucleoside is a basic building block of the nucleic acids, DNA and RNA, the genetic material of all living cells and viruses. Nucleosides consist of a molecule of sugar linked to a nitrogen-containing organic ring
compound. In the most important naturally occurring nucleosides, the sugar is either ribose (used to construct RNA) or deoxyribose (used to construct DNA), and the nitrogen-containing organic ring compound, referred to as the base, is either a
pyrimidine (cytosine, thymine, or uracil) or a purine (adenine or guanine). A nucleoside combined with a phosphate group becomes a nucleotide.



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In biological systems, nucleotides are linked by enzymes, including the polymerase, in a
specific order to make long, chainlike polynucleotides (DNA or RNA) of defined sequence to pass along genetic information for a specific protein, a gene, or an entire organism, a genome. A nucleoside analog is a synthetic molecule that
resembles a naturally occurring nucleoside. Chemical modifications in either the sugar portion or the base portion allow these compounds, once phosphorylated, to inhibit or disrupt the activity of the polymerase. When a nucleotide analog is
incorporated into viral DNA or RNA during replication, it acts to prevent production of new virus by blocking the complete synthesis of the new viral DNA or RNA genome.

Experimentsin vitro conducted by us and others show that nucleoside/tide analogs have conserved antiviral activity across all HCV
genotypes. This characteristic of the nucleoside/tide analog class relates to its unique mechanism of action. Recent clinical studies of RG7128, as more fully described below, show comparable anti-HCV activity across HCV genotypes 1, 2, and 3. Other
classes of anti-HCV drugs (i.e., protease inhibitors and non-nucleoside polymerase inhibitors) tested show diminished antiviral activity in genotypes other than genotype 1.

In clinical monotherapy studies with three separate nucleoside/tide analogs (including RG7128) over 14 days, viral breakthrough while on
therapy did not occur. In studies of non-nucleoside polymerase and protease inhibitors, viral breakthrough was seen as early as three to four days into the 14-day treatment period. The relative rapidity of the breakthrough with these classes of
drugs suggests that the patients may have harbored HCV strains that were not susceptible to at least one component of the therapeutic regimen. With longer exposure to any DAA, drug resistant virus may be selected over time. The rapidity and
frequency with which this occurs may have significant consequences for patients, including not obtaining an SVR.

Summary
of Nucleoside/tide Analogs and Their Potential Use as Future Therapy

Current market research identifies the three most
important attributes for improving HCV therapy, in order of importance, as: greater efficacy, improved tolerability, and shorter duration of treatment. Current guidance from regulatory authorities indicates that approval of DAAs for HCV must include
their use in combination with SOC. Therefore, most efforts to improve SVR rates focus on adding a DAA on to SOC. It is hoped that the addition of a drug which directly inhibits viral growth will result in a more efficacious therapy without adding to
the intolerability of interferon and ribavirin. We and other developers of HCV DAAs are currently investigating the use of DAAs in an attempt to improve upon current HCV therapy. We are focused on discovering and developing nucleoside/tides for HCV
as they have shown potential advantages over other classes of drug candidates.

Pyrimidine
Nucleoside/tide Product Candidates

RG7128 Development

Phase 1 Studies. In October 2004, we entered into a collaboration with Roche for the development and commercialization of PSI-6130
(an oral cytidine nucleoside analog polymerase inhibitor which we discovered) and its prodrugs, including RG7128, for the treatment of HCV. A prodrug is a chemically modified form of a molecule designed to enhance the absorption, distribution, and
metabolic properties of that molecule. Roche and we initiated an adaptive Phase 1 clinical trial with RG7128 in October 2006 under an IND filing. On October 12, 2007, we were informed by the FDA that RG7128 received fast track designation.
During December 2008, we completed the Phase 1 clinical trial. Following is a review of the design and results of this trial.



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This adaptive Phase 1 clinical trial of RG7128 was a multiple center, observer-blinded,
randomized, and placebo-controlled study designed to investigate the pharmacokinetics, pharmacodynamics, safety, tolerability, and food effect of RG7128 in healthy subjects and in patients chronically infected with HCV genotypes 1, 2, or 3.
This trial provided antiviral potency data over 14 and 28 days in patients chronically infected with HCV genotype 1, and over 28 days of treatment in patients chronically-infected with HCV genotypes 2 or 3 who had not responded to prior
interferon-based therapy. This study included three parts:



| |  |  | Part 1 was a single ascending dose (SAD) study conducted in 46 healthy subjects. The primary objective of Part 1 was to assess the safety,
tolerability, and pharmacokinetics of RG7128 following single ascending doses under fasting conditions. The secondary objective of Part 1 was to explore the effect of food on the pharmacokinetics of RG7128. Single oral doses of RG7128 were
administered to 46 healthy subjects in five sequential dose groups (500mg, 1500mg, 4500mg, 6000mg, and 9000mg) and one food effect group (1500mg). Results from the single ascending dose portion of the study indicated:
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | All doses of RG7128 studied (500mg to 9000mg) were generally safe and well-tolerated.
| | - |  | -------------------------------------------------------------------------------------



| |  |  | All patients completed the study and none experienced gastrointestinal adverse events or serious adverse events during the study.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------



| |  |  | No hematological or other safety laboratory abnormalities of clinical significance were noted.
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | No maximum tolerated dose was identified.
| | - |  | -----------------------------------------



| |  |  | Part 2 was a multiple ascending dose study (MAD) conducted in 40 patients chronically infected with HCV genotype 1 who had previously
failed interferon therapy. The primary objective of Part 2 was to assess the safety, tolerability, and pharmacokinetics of RG7128 after once-daily (QD) or twice-daily (BID) dosing for 14 days. The secondary objective was to
assess antiviral efficacy by measuring the change from baseline in circulating HCV RNA. Results from the multiple ascending dose portion of the study indicated:
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | RG7128 demonstrated potent, dose-dependent antiviral activity in four patient cohorts (8 active and 2 placebo per cohort) receiving 750mg or 1500mg
administered either QD or BID for 14 days as monotherapy. RG7128 demonstrated mean HCV RNA decreases from baseline of 0.9
log10(87.4% reduction), 1.5
log10(96.8% reduction), 2.1
log10(99.2% reduction), and 2.7
log10(99.8% reduction) in patients receiving 750mg QD,
1500mg QD, 750mg BID, and 1500mg BID, respectively. A maximum reduction in HCV RNA of 4.2
log10(99.9% reduction) was demonstrated in a patient
following 14 days of monotherapy with RG7128 1500mg BID, a value also below the limit of detection, which was 15 International Units per milliliter (IU/ml).
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | There was no evidence of drug resistance in any dose cohort during the 14 days of dosing.
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | RG7128 was generally safe and well tolerated over 14 days of treatment.
| | - |  | -----------------------------------------------------------------------



| |  |  | Part 3 was a 4-week study of RG7128 in combination with SOC in 81 treatment-naïve patients chronically infected with HCV genotype 1, and
additionally, in 25 prior treatment non-responders, or patients who did not achieve an SVR with previous interferon-based therapy, who were chronically infected with HCV genotypes 2 or 3. The primary objective of this study was to assess the safety,
tolerability, and pharmacokinetics of RG7128 in the clinically-relevant setting of combination therapy with SOC for chronic HCV infection. The secondary objective of Part 3 was to evaluate the short-term change in HCV RNA. The study included three
oral dose regimens of RG7128 (500mg, 1000mg, and 1500mg BID  cohorts 1, 2, and 3, respectively) in patients chronically infected with HCV genotype 1 and one oral dose regimen of RG7128 (1500mg BID  cohort 4) in patients chronically
infected with HCV genotypes 2 or 3.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



23



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##### Table of Contents

The antiviral results for cohorts 1, 2, and 3 are summarized in the following table:



|                 |  |    |  |                                 |  |                               |      
|---------------- |  | -- |  | ------------------------------- |  | ----------------------------- | -----
|RG7128 dose      |  | N  |  | Mean HCVRNA 
changefromBaseline |  | HCV 
RNA<LLOD1(<15IU/mL)N (%) |      
|                 |  |   
|500mg BID + SOC  |  | 20 |  | -3.8                            |  | 6/20                          | (30%)
|1000mg BID + SOC |  | 25 |  | -5.1                            |  | 22/25                         | (88%)
|1500mg BID + SOC |  | 20 |  | -5.1                            |  | 17/20                         | (85%)
|Placebo + SOC    |  | 16 |  | -2.9                            |  | 3/16                          | (19%)

1 LLOD means lower limit of detection by Roche Taqman Assay

For cohorts 1, 2, and 3 in treatment-naïve genotype 1 patients, RG7128 was generally safe and well-tolerated when administered for 4
weeks in combination with SOC in patients with HCV genotype 1.

The antiviral results for the 1500mg BID dose cohort (cohort 4)
in 25 prior treatment non-responders (patients who did not achieve an SVR with previous interferon-based therapy) who were chronically infected with HCV genotype 2 or 3 are summarized in the following table:



|                 |  |    |  |                                 |  |                               |      
|---------------- |  | -- |  | ------------------------------- |  | ----------------------------- | -----
|RG7128 dose      |  | N  |  | Mean HCVRNA 
changefromBaseline |  | HCV 
RNA<LLOD1(<15IU/mL)N (%) |      
|                 |  |   
|1500mg BID + SOC |  | 20 |  | -5.0                            |  | 19/20                         | (95%)
|Placebo + SOC    |  | 5  |  | -3.7                            |  | 3/5                           | (60%)

1 LLOD means lower limit of detection by Roche Taqman Assay

RG7128 was generally safe and well-tolerated in cohort 4. After receiving 4 weeks of RG7128 in combination with SOC, the 20 patients
infected with HCV genotype 2 or 3 continued to receive SOC alone for an additional 20 to 44 weeks as determined by their prior response and HCV genotype. Twenty-four weeks after the end of all treatment, 65% (13 of 20) of these patients demonstrated
an SVR.

Phase 2b Study.In April 2009, Roche began dosing in a Phase 2b PROPEL study with RG7128. During
May 2010, dosing of RG7128 triple combination therapy (RG7128 plus SOC) or placebo plus SOC in 408 treatment-naïve, genotype-1 or genotype-4 HCV-infected patients (cirrhotic and non-cirrhotic) was completed. The trial is evaluating the dose and
duration of treatment of RG7128 in combination with SOC. The primary efficacy endpoint of the trial will be the proportion of patients that achieve an SVR. Subjects were equally randomized into one of 5 arms of the study:



| |  |  | 24 weeks of total treatment, with RG7128 500mg BID in combination with SOC for 12 weeks, followed by 12 weeks of SOC
| | - |  | --------------------------------------------------------------------------------------------------------------------



| |  |  | 24 weeks of total treatment, with RG7128 1000mg BID in combination with SOC for 12 weeks, followed by 12 weeks of SOC
| | - |  | ---------------------------------------------------------------------------------------------------------------------



24



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##### Table of Contents

| |  |  | 24 weeks of total treatment, with RG7128 1000mg BID in combination with SOC for 8 weeks, followed by 16 weeks of SOC
| | - |  | --------------------------------------------------------------------------------------------------------------------



| |  |  | 48 weeks of total treatment, with RG7128 1000mg BID in combination with SOC for 12 weeks, followed by 36 weeks of SOC
| | - |  | ---------------------------------------------------------------------------------------------------------------------



| |  |  | A control arm with only SOC for 48 weeks
| | - |  | ----------------------------------------

Patients in the 24 week cohorts will discontinue treatment at week 24 if they achieved a rapid virologic response (RVR),
defined as HCV RNA below the limit of detection (<15 IU/mL as measured by TaqMan assay) four weeks after the initiation of treatment, that is maintained until week 22, a strategy known as RVR-guided treatment. Patients who do not
achieve an RVR will continue on SOC until week 48.

Interim results as of early June 2010 from all 408 patients who had
completed the first 12 weeks of the PROPEL study indicate that triple combination therapy of RG7128 and SOC was safe and well tolerated and was similar to the safety profile of SOC alone. The interim results also indicate that greater than 80% of
all of the patients receiving 12 weeks of the triple combination therapy had HCV RNA below the limit of detection, compared to less than 50% of the patients in the control arm of the study. No viral rebounds or resistance-related breakthroughs were
noted during the first 8 or 12 weeks of RG7128 triple combination therapy, which is consistent with the high barrier to resistance demonstrated in earlier clinical trials of RG7128.

An amendment to the protocol for the PROPEL study has been implemented which allows patients who were initially randomized to the
placebo/SOC arm and who are non-responders to receive open label RG7128 1000mg BID in combination with SOC for 24 weeks, followed by an additional 24 weeks of SOC. Non-response is defined as a patient who does not achieve at least a 2 log decline in
HCV RNA by week 12 of therapy, or who has HCV RNA above the limit of detection (15 IU/mL) at week 24 of therapy. This amendment will provide longer-term treatment data on patients with prior non-response to SOC, including demonstrated null
responders.

Roche has also initiated a 24+0 Phase 2b study of RG7128 in combination with SOC in 160
treatment-naïve patients with HCV genotypes 1 and 4 to evaluate the safety and efficacy of RG7128 in combination with SOC for 24 weeks with no SOC follow-up. Patients who achieve an RVR will stop all therapy (RG7128 and SOC) at week 24, while
patients who do not achieve RVR will receive a full 48 weeks of SOC. Supportive data from this study could provide the flexibility for longer dosing of RG7128 which may be required in some populations, as well as combinations of RG7128 with other
direct acting antivirals currently in development. This study completed enrollment during the second calendar quarter of 2010 and is being conducted at sites in the U.S. and Canada. Patients were initially equally randomized into one of two arms of
the study:



| |  |  | 24 weeks of treatment, with RG7128 1000mg BID in combination with SOC
| | - |  | ---------------------------------------------------------------------



| |  |  | A control arm with placebo and SOC for 48 weeks
| | - |  | -----------------------------------------------

An amendment to the protocol for this 24-week study has been implemented which allows patients who were initially randomized to the
placebo/SOC arm and who are non-responders to receive open label RG7128 1000mg BID in combination with SOC for 24 weeks, followed by an additional 24 weeks of SOC. Non-response is defined as a patient who does not achieve at least a 2 log decline in
HCV RNA by week 12 of therapy, or who has HCV RNA above the limit of detection (15 IU/mL) at week 24 of therapy. Patients from this study as well as the initial Phase 2b PROPEL study of 12 weeks RG7128 who are randomized to
placebo/SOC (described above) will provide longer-term treatment data on patients with prior non-response to SOC, including demonstrated null responders.

In addition, Roche is planning to initiate a Phase 2b study of RG7128 in combination with SOC in patients with HCV genotypes 2 and 3
during the first half of calendar year 2011. RG7128 in combination with SOC has previously demonstrated antiviral activity in HCV genotypes 2 and 3 prior non-responders in a 28 day clinical trial, with an RVR of 95% and an SVR of 65%. Roche plans to
submit a marketing application for RG7128 to one or more regulatory authorities in 2013.



25



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##### Table of Contents

PSI-7977 Development

PSI-7977 is an isomer of PSI-7851 and a prodrug of a uridine nucleotide analog polymerase inhibitor we are developing for the treatment
of chronic HCV infection. PSI-7851 demonstrated potent in vitro anti-HCV activity with EC90 values of 0.44 +/- 0.21 uM, between 14 and 17-fold more potent than the active metabolite of our cytidine nucleoside polymerase inhibitor, PSI-6130.
The in vitro half-life of the triphosphate (the biologically active form of the molecule) in primary human hepatocytes is approximately 38 hours, which supports the exploration of once-daily dosing in early studies. Like RG7128, PSI-7851 has
demonstrated in vitro activity against HCV genotypes 1, 2, 3, and 4.

PSI-7851 is a mixture of two molecules of
identical chemical composition, PSI-7976 and PSI-7977, which only differ in the stereo-orientation of one of the atoms on the prodrug. Once inside a liver cell, both molecules are rapidly converted to the same active triphosphate. Given the
improvements in manufacturing and slightly better in vitro potency, we selected PSI-7977 for further clinical development. We also made improvements in the formulation, which we evaluated in a Phase 1 study in healthy volunteers. Following
are results from the Phase 1 single and multiple ascending dose studies of PSI-7851, which were followed by the initiation of our Phase 2a study of PSI-7977.

Phase 1 Studies. In March 2009, we initiated a Phase 1 study of PSI-7851, which was a single ascending dose (SAD)
study that assessed the safety, tolerability, and pharmacokinetics of PSI-7851 in 42 healthy subjects at doses ranging from 25mg to 800mg. Results from this study indicated there were:



| |  |  | No dose-limiting toxicity,
| | - |  | --------------------------



| |  |  | No serious adverse events, and
| | - |  | ------------------------------



| |  |  | No clinically significant changes in vital signs or electrocardiograph (ECG) readings.
| | - |  | ----------------------------------------------------------------------------------------

In June 2009, we initiated a Phase 1 multiple ascending dose (MAD) study in HCV-infected patients. Forty subjects were
enrolled at two U.S. centers and randomized to PSI-7851 (8 per cohort) or placebo (2 per cohort). The primary objective of this study was to assess the safety, tolerability, and pharmacokinetics of PSI-7851 after once-daily dosing for three days.
The secondary objective of this study was to assess antiviral activity by measuring the change in circulating HCV RNA levels. Four dose cohorts of PSI-7851 (50mg QD, 100mg QD, 200mg QD, and 400mg QD) were evaluated. Results from this study to date
indicate:



| |  |  | PSI-7851 was generally safe and well tolerated across all cohorts with no discontinuations, no serious adverse events, and no dose-related trends in
adverse events or laboratory abnormalities.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | PSI-7851 demonstrated potent antiviral activity with a mean HCV RNA change from baseline of -0.49
log10IU/mL in patients receiving 50mg QD and -0.61
log10IU/mL in patients receiving 100mg QD.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | PSI-7851 200mg QD administered for 3 days resulted in a mean change from baseline HCV RNA of -1.01
log10IU/mL, with 6 of 8 subjects achieving greater than a
1.0 log10IU/mL decline from baseline. This antiviral effect
met our threshold of approximately 1.0 log10IU/mL decline
over three days as established with the first-in-class nucleoside, RG7128.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | PSI-7851 400mg QD administered for 3 days resulted in a mean change from baseline HCV RNA of -1.95
log10IU/mL, with 6 of 8 subjects achieving greater than a
1.5 log10IU/mL decline from baseline.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Phase 2a Study. During January 2010, we initiated a 28-day Phase 2a study of PSI-7977 and enrolled
63 patients with genotype 1 chronic HCV infection who had not been treated previously. The primary goal of the study was to determine the safety and tolerability of PSI-7977 in combination with SOC. The primary efficacy endpoint of the trial was the
proportion of patients who achieve an RVR. Patients will continue to be followed through an SVR endpoint. Patients were randomized to receive one of four treatments:



| |  |  | PSI-7977 100mg QD in combination with SOC for 28 days, followed by 44 weeks of SOC alone (n=16)
| | - |  | -----------------------------------------------------------------------------------------------



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##### Table of Contents

| |  |  | PSI-7977 200mg QD in combination with SOC for 28 days, followed by 44 weeks of SOC alone (n=18)
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | PSI-7977 400mg QD in combination with SOC for 28 days, followed by 44 weeks of SOC alone (n=15)
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | A control arm with placebo in combination with SOC for 48 weeks (n=14)
| | - |  | ----------------------------------------------------------------------

The baseline HCV RNA for all patients enrolled in the study was approximately 6.5
log10IU/mL, and was similar across all treatment arms.
Results from this study to date are summarized in the following table:



|                        |  |                                                  |  |                                                                    
|----------------------- |  | ------------------------------------------------ |  | -------------------------------------------------------------------
|Study Arm               |  | Mean decrease in HCV 
RNA(log10 IU/mL) at Day 28 |  | Percentage of Patients withHCV RNA below
LLOD1(<15 IU/mL) at Day 28
|100mg PSI-7977 QD + SOC |  | -5.32                                            |  | 88%(14/16)                                                         
|200mg PSI-7977 QD + SOC |  | -5.06                                            |  | 94%(17/18)                                                         
|400mg PSI-7977 QD + SOC |  | -5.33                                            |  | 93%(14/15)                                                         
|Placebo + SOC           |  | -2.80                                            |  | 21%(3/14)                                                          

1 LLOD means lower limit of detection by Roche Taqman Assay

Safety and
tolerability for the 28-day treatment period were similar for PSI-7977 in combination with SOC compared to placebo in combination with SOC. We anticipate initiating a 12-week Phase 2b study of PSI-7977 during the fourth calendar quarter of 2010.

Combination Treatment with Two or More Direct Acting Antivirals

The use of interferon in the current standard of care limits the number of patients who can or are willing to undergo therapy for HCV and
may result in less compliance with treatment regimens. We believe that the combination of two or more DAAs may provide an SVR in the absence of interferon. The selection of the drugs in such combinations focuses on molecules which lack metabolic
interaction and possess complementary resistance profiles.

The frequent emergence of resistant variants in HCV inhibitor
monotherapy trials suggests that combinations of DAAs with complementary resistance profiles and differing metabolic pathways may be required to treat HCV. Based on consultations with experts in the field, we believe the combination of at least one
nucleoside/tide analog with, for example, a protease inhibitor or non-nucleoside polymerase inhibitor, or one nucleoside/tide combined with a second complementary nucleoside/tide, present potentially useful therapeutic regimens. These different
classes of DAAs possess complementary resistance profiles and differing metabolic pathways, suggesting that they will not adversely affect or antagonize the antiviral activity of the other compound. In addition, nucleoside/tide analogs have
demonstrated in vitro the ability to suppress the resistant variants that emerge with partially-suppressive concentrations of protease inhibitors or non-nucleoside polymerase inhibitors. Clinical use of a combination of DAAs may provide
improved antiviral activity across HCV genotypes and may lead to interferon-sparing regimens.

INFORM Studies. During
November 2008, Roche, InterMune, Inc. (InterMune), and we announced the initiation of a Phase 1 study to investigate the combination of two DAAs in the absence of interferon and ribavirin. This study, named INFORM-1, combined for the
first time in patients naïve to therapy and in patients who previously failed therapy (TF) two oral DAAs, RG7128 and danoprevir (formerly RG7227). Danoprevir is an inhibitor of the HCV NS3/4 protease, which is being developed by
InterMune in collaboration with Roche.

INFORM-1 was a randomized, double-blind, ascending dose Phase 1 trial that enrolled a
total of 86 patients and was conducted by Roche. The principal objectives were to evaluate safety, tolerability, and antiviral activity of RG7128 and danoprevir administered in combination at increasing doses for up to 13 days. Results from this
study demonstrated for the first time that the combination of an oral protease inhibitor and an oral nucleoside polymerase inhibitor resulted in significant circulating HCV RNA reduction in patients with HCV, as patients receiving the combination of
danoprevir and RG7128 for 13 days (without pegylated interferon or ribavirin) experienced a median



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##### Table of Contents

reduction in HCV RNA of -4.8 to -5.2
log10IU/mL in the highest dose levels tested. In addition,
no treatment-related serious adverse events, dose reductions, or discontinuations were reported during the study. Pharmacokinetic analyses also confirmed that there were no drug-drug interactions between the compounds. Following is a figure that
presents by dose regimen the median log10HCV RNA change from
baseline over the 13 days of treatment.

LOGO

The antiviral results for each dose regimen are summarized in the following table.



|                             |  |   |  |                   |   |  |                                |    |  |                                |   
|---------------------------- |  | - |  | ----------------- | - |  | ------------------------------ | -- |  | ------------------------------ | --
|Regimen (RG7128 / RG7227 mg) |  | N |  | PatientPopulation |   |  | HCV RNA<LLOQ1(<43 
IU/mL)N (%) |    |  | HCV RNA<LLOD2(<15 
IU/mL)N (%) |   
|500 BID/100 TID              |  | 8 |  | Naïve             |   |  | 1/8(13                         | %) |  | 1/8(13                         | %)
|500 BID/200 TID              |  | 8 |  | Naïve             |   |  | 5/8(63                         | %) |  | 2/8(25                         | %)
|1000 BID/100 TID             |  | 7 |  | Naïve             |   |  | 5/7(71                         | %) |  | 2/7(29                         | %)
|1000 BID/200 TID             |  | 8 |  | Naïve             |   |  | 5/8(63                         | %) |  | 2/8(25                         | %)
|1000 BID/600 BID             |  | 8 |  | TF (non-null      | ) |  | 4/8(50                         | %) |  | 1/8(13                         | %)
|1000 BID/900 BID             |  | 8 |  | TF (null          | ) |  | 4/8(50                         | %) |  | 2/8(25                         | %)
|1000 BID/900 BID             |  | 8 |  | Naïve             |   |  | 7/8(88                         | %) |  | 5/8(63                         | %)

1 LLOQ means lower limit of quantification by Roche Taqman Assay

2 LLOD means lower limit of detection by Roche Taqman Assay

The higher dose combination of RG7128 1000mg and danoprevir 900mg administered twice daily without pegylated
interferon or ribavirin for 13 days resulted in 88% of HCV-positive treatment-naïve patients achieving HCV RNA below the lower limit of quantification (LLOQ), and 63% of patients having HCV RNA below the lower limit of detection
(LLOD). The same regimen in null-responders resulted in 50% of patients with HCV RNA below LLOQ and 25% of patients with HCV RNA below LLOD. Null responders were defined as patients with a documented failure to
achieve a 1.0 log10or greater decline in HCV RNA in 4 weeks
or a 2.0 log10or greater decline in HCV RNA in 12 weeks of
prior treatment with pegylated interferon and ribavirin.



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##### Table of Contents

In February 2010, Roche announced that it will not conduct the previously planned 28 day
INFORM-2 study, designed to evaluate the combination of RG7128 with danoprevir, InterMunes HCV protease inhibitor, with and without pegylated interferon and ribavirin. Roche has decided instead to conduct longer duration studies of at least 12
weeks of RG7128 and danoprevir with and without SOC. The next INFORM study will commence after Roche and InterMune identify a dose level for ritonavir-boosted RG7227 from ongoing studies.

Pharmassets Proprietary DAA Combinations

Our drug discovery efforts are now primarily focused on the identification of purine nucleoside/tides that have resistance profiles that
complement the resistance profiles of our pyrimidine analog product candidates, RG7128 and PSI-7977. Purines are phosphorylated by different enzymes than the pyrimidines, and thus should not antagonize the activity of the pyrimidines. In
vitro, the combination of a purine analog with a pyrimidine analog provides additive to synergistic antiviral activity, potentially due to the fact that each of these classes of analogs compete with a different class of naturally occurring
nucleotides for incorporation into nascent HCV RNA. Such complementary activities offer the potential for a potent dual nucleoside/tide analog-based combination for the future treatment of HCV.

Due to the unique attributes of nucleoside/tides, we believe a combination of two nucleoside/tides could possess a competitive advantage
over SOC. We also believe that other combinations including a protease inhibitor or non-nucleoside polymerase inhibitor may be limited in their efficacy due to (1) their limited utility in genotypes other than Genotype 1, and (2) their
lower barriers to resistance. Inclusion of a nucleoside/tide in such a combination may improve its barrier to resistance. A dual nucleoside/tide combination could potentially provide therapeutic activity for all genotypes. In addition, since
nucleoside/tides possess favorable resistance profiles, we believe that dual nucleoside/tide combinations could possess an advantage over other combinations that incorporate drug classes with less robust resistance profiles. This strategy of dual
nucleoside/tide therapy underpins the current standard of care in HIV. Fixed-dose combinations of nucleoside/tides approved to treat HIV have long provided additional advantages, such as ease of compliance and reduced emergence of resistance.

Purine Nucleotide Product Candidates

Guanosine Program  PSI-938 and PSI-661

In 2007, we launched a purine nucleotide research and development program and in 2009, we nominated two guanine nucleotide analog
polymerase inhibitors, PSI-938 and PSI-661, as development candidates. PSI-938 and PSI-661 have demonstrated potent in vitro anti-HCV activity with EC90 values of 1.43 +/- 0.67 μM and 0.01 +/- 0.005 μM, respectively. PSI-938 and
PSI-661 have many of the benefits of our pyrimidine nucleoside/tide analogs, RG7128 and PSI-7977, in that they:



| |  |  | Have demonstrated similar in vitro activity across multiple HCV genotypes,
| | - |  | --------------------------------------------------------------------------



| |  |  | Have a higher barrier to resistance than other classes of HCV small molecules in development
| | - |  | --------------------------------------------------------------------------------------------



| |  |  | Have no CYP 3A4 liability and thus a lower risk of drug interactions when combined with other direct acting antivirals targeting HCV.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------

PSI-938 and PSI-661 retain equivalent potency against wildtype HCV and virus with the S282T mutation associated with in
vitro resistance in other nucleoside/tide analogs under development, such as RG7128, PSI-7977, IDX184 and INX189. Furthermore, the purines are metabolized to the same active triphosphate form through a different phosphorylation pathway than the
pyrimidine analogs, RG7128 and PSI-7977, thus decreasing the risk of metabolic competition during phosphorylation. The in vitro half-life of the triphosphate in primary human hepatocytes is approximately 12 hours for PSI-938 and PSI-661,
which supports the exploration of once-daily dosing in early development. The main difference between PSI-938 and PSI-661 is that PSI-661 uses a different prodrug strategy than PSI-938. Based on these characteristics, PSI-938 and PSI-661 have the
potential to be combined with our pyrimidine analogs as part of a future regimen, which is expected to be the focus of upcoming trials. Our plan is to select one of these product candidates for later-stage clinical development based upon a review of
the early human clinical trial results of both PSI-938 and PSI-661.



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PSI-938 Development

Phase 1 Studies. In April 2010, we initiated a Phase 1 study of PSI-938, which was a SAD study to assess the safety, tolerability, and
pharmacokinetics of PSI-938 following single oral administration in healthy subjects. Preliminary results from this study include:



| |  |  | No dose-related adverse events or dose-limiting toxicity,
| | - |  | ---------------------------------------------------------



| |  |  | No serious adverse events or discontinuations,
| | - |  | ----------------------------------------------



| |  |  | No grade III / IV lab abnormalities,
| | - |  | ------------------------------------



| |  |  | No clinically significant changes in vital signs or ECGs, and
| | - |  | -------------------------------------------------------------



| |  |  | Pharmacokinetics which support QD dosing.
| | - |  | -----------------------------------------

During July 2010, we initiated dosing in a Phase 1 MAD study of PSI-938 in treatment naïve patients with HCV genotype 1. Subjects
will be enrolled and randomized to PSI-938 (8 per cohort) or placebo (2 per cohort). The primary objective of the study is to assess the safety, tolerability, and pharmacokinetics of PSI-938 administered over seven days. The secondary objective of
Part 1 of this study is to assess antiviral activity by measuring the change in circulating HCV RNA levels. Based upon the results from the single ascending dose study, the starting dose of PSI-938 will be 100mg administered once daily.

We intend to report preliminary data from the MAD study during the fourth calendar quarter of 2010.

PSI-661 Development

PSI-661 is a prodrug of a guanine nucleotide analog polymerase inhibitor which we are developing for the treatment of chronic HCV
infection. It is in advanced preclinical development and our current plan is to submit an IND application, or its foreign equivalent, during the fourth calendar quarter of 2010.

Product Candidate for the Treatment of HIV

Racivir

Racivir is an oral, once-daily deoxycytidine nucleoside analog that we are developing as an HIV therapy for use in
combination with other approved HIV drugs. In a completed Phase 2 clinical trial, for the subset of patients carrying the M184V mutation and less than three thymidine analog mutations, replacing lamivudine with Racivir in their existing combination
therapies caused a mean decrease in plasma HIV RNA of 0.7
log10(80% reduction) in the second week of treatment.
Twenty-eight percent of these patients achieved an undetectable level of HIV RNA (less than 400 copies per milliliter) and 64% of these patients achieved at least a 0.5
log10decrease (68% reduction) in plasma HIV RNA.

Financial History

We have incurred substantial operating losses since our inception because we have devoted substantially all of our resources to our
research and development activities and have not generated any revenue from the sale of approved drugs. As of June 30, 2010, we had an accumulated deficit of $213.3 million. We expect our operating losses to increase for at least the next
several years as we continue to pursue the clinical development of PSI-7977, PSI-938, and PSI-661 and as we expand our discovery and development pipeline.

We have funded our operations primarily through the sale of equity securities, payments received under collaboration agreements,
borrowings under our Loan Agreement, and interest earned on investments. We expect to continue to fund our operations over the next several years through our existing cash resources, borrowings under our Loan Agreement, potential future milestone
payments that we expect to receive from Roche if certain conditions are satisfied, interest earned on our investments, payments received under potential future collaboration or other strategic



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partnership agreements, and additional capital to be raised through public or private equity offerings or debt financings. We will require significant additional financing in the future to fund
our operations. Additional financing may not be available on acceptable terms, if at all. As of June 30, 2010, we had $144.4 million of cash and cash equivalents.

Revenues

All of our product candidates are currently in development and, therefore, we do not expect to generate any direct revenues from product
sales for at least the next several years, if at all. Our revenues to date have been generated primarily from milestone payments under our collaboration agreements, license fees, and research funding. We currently have one collaboration agreement
with Roche for the development of RG7128. We entered into our collaboration agreement with Roche in October 2004. Roche subsequently paid us an up-front payment of $8.0 million. As of June 30, 2010, we had received an aggregate of
$44.5 million in payments under the Roche collaboration agreement, including research funding and related fees as well as up-front and milestone payments.

Under the current terms of the Roche collaboration agreement, if we and Roche succeed in obtaining all of the regulatory approvals
specified in the agreement for RG7128, as of June 30, 2010 the maximum future development and commercialization milestone payments payable to us is $105.0 million. Receipt of any additional milestone payments depends on many factors, some of
which are beyond our control. We cannot assure you that we will receive any of these future payments.

We expect our revenues
for the next several years to be derived primarily from payments under our current collaboration agreement with Roche and any additional collaborations that we may enter into in the future. In addition to the payments described above, we may receive
future royalties on product sales, if any, under our collaboration agreement with Roche.

Research and Development
Expenses

Our research and development expenses consist primarily of salaries and related personnel expenses, fees paid
to external service providers, up-front and milestone payments under our license agreements, patent-related legal fees, costs of preclinical studies and clinical trials, drug and laboratory supplies, and costs for facilities and equipment. We use
external service providers to manufacture our product candidates for clinical trials and for the majority of our preclinical and clinical development work. We charge all research and development expenses to operations as they are incurred.
Nonrefundable advance payments for goods or services that will be used or rendered for future research and development activities are deferred and capitalized. Such amounts are then recognized as an expense as the related goods are delivered or the
services are performed, or when the goods or services are no longer expected to be provided.

Our research activities are
primarily focused on discovering and developing novel drugs to treat HCV. Our development activities are primarily focused on the development of RG7128 (in collaboration with Roche), PSI-7977, PSI-938, and PSI-661 for the treatment of HCV and,
secondarily, on the development of Racivir for the treatment of HIV. We are responsible for all costs incurred in the clinical development of PSI-7977, PSI-938, PSI-661, and Racivir, as well as the research costs associated with our other internal
research programs. On April 20, 2009, we announced that we would be voluntarily terminating our Phase 3 registration studies of clevudine for the treatment of hepatitis B virus.

Under our collaboration with Roche, Roche will fund the clinical development and commercialization of RG7128. Under this collaboration,
Roche reimbursed us for all of the external expenses associated with, and we were responsible for, certain preclinical work, the IND filing, and the proof-of-concept clinical trial. During December 2008, we transferred the IND application for RG7128
to Roche. Roche will continue to fund all of the expenses of, and be responsible for, other preclinical studies and future clinical development of RG7128 in the territories licensed to Roche. We and Roche will continue to jointly oversee all
development and marketing activities of RG7128 in the territories licensed to Roche. Roche received a license only to PSI-6130 and its pro-drugs, including RG7128.

We use our internal research and development resources, including our employees and discovery infrastructure, across various projects.
Our related internal expenses are not attributable to a specific project, but are directed to broadly applicable research activities. Accordingly, we do not account for our internal research and development expenses on a project basis. We use
external service providers to manufacture our product candidates for clinical trials and for the substantial majority of our preclinical and clinical development work. We have tracked some of these external research and development expenses on a
project basis. To the extent that expenses are not attributable to a specific project, they are included in one of the unattributed expenses in the table below.



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The following table summarizes our research and development expenses for our current
development programs, as well as clevudine, for the three and nine months ended June 30, 2010 and 2009:



|                                                    |  |                           |        |                          |   |                         |  |      |        |  |   |        |  |   |       
|--------------------------------------------------- |  | ------------------------- | ------ | ------------------------ | - | ----------------------- |  | ---- | ------ |  | - | ------ |  | - | ------
|                                                    |  | Three MonthsEnded
June 30 |        | Nine MonthsEnded
June 30 |   | CumulativeProject Costs
|                                                    |  | 2010                      |        | 2009                     |   | 2010                    |  | 2009 |        | 
|                                                    |  | (In thousands)            |        |                         
|Expenses attributed to projects:                    |  |                           |        |                          |   |                         |  |      |        |  |   |        |  |   |       
|RG7128 Studies *                                    |  | $                         |       |                          | $ |                        |  | $    |       |  | $ |       |  | $ |      
|PSI-7977 (including PSI-7851) Studies               |  |                           | 4,131  |                          |   | 1,901                   |  |      | 10,620 |  |   | 4,051  |  |   | 18,281
|PSI-938 Studies                                     |  |                           | 1,585  |                          |   | 287                     |  |      | 3,627  |  |   | 432    |  |   | 4,940 
|PSI-661 (including PSI-879) Studies                 |  |                           | 1,265  |                          |   |                        |  |      | 3,630  |  |   |       |  |   | 3,633 
|Phase 2 Racivir Studies                             |  |                           |       |                          |   | 5                       |  |      |       |  |   | 39     |  |   | 4,237 
|Clevudine Studies                                   |  |                           |       |                          |   | 7,098                   |  |      | 1,350  |  |   | 23,437 |  |   | 72,959
|                                                    |  |                           |        |                          |   |                         |  |      |        |  |   |        |  |   |       
|Total attributed expenses                           |  |                           | 6,981  |                          |   | 9,291                   |  |      | 19,227 |  |   | 27,959 |  |   |       
|                                                    |  |                           |        |                          |   |                         |  |      |        |  |   |        |  |   |       
|Unattributed expenses                               |  |                           |        |                          |   |                         |  |      |        |  |   |        |  |   |       
|Salaries and related personnel expenses             |  |                           | 2,057  |                          |   | 2,043                   |  |      | 6,044  |  |   | 6,094  |  |   |       
|Non-cash stock compensation expense                 |  |                           | 701    |                          |   | 580                     |  |      | 2,452  |  |   | 1,945  |  |   |       
|Legal expenses associated with patents              |  |                           | 386    |                          |   | 141                     |  |      | 1,218  |  |   | 1,051  |  |   |       
|Preclinical studies and new drug discovery services |  |                           | 520    |                          |   | 615                     |  |      | 1,442  |  |   | 1,457  |  |   |       
|Drug and laboratory supplies                        |  |                           | 257    |                          |   | 261                     |  |      | 765    |  |   | 747    |  |   |       
|Consulting expense                                  |  |                           | 181    |                          |   | 212                     |  |      | 621    |  |   | 639    |  |   |       
|Facility and other expenses                         |  |                           | 422    |                          |   | 534                     |  |      | 962    |  |   | 1,502  |  |   |       
|                                                    |  |                           |        |                          |   |                         |  |      |        |  |   |        |  |   |       
|Total unattributed expenses                         |  |                           | 4,524  |                          |   | 4,386                   |  |      | 13,504 |  |   | 13,435 |  |   |       
|                                                    |  |                           |        |                          |   |                         |  |      |        |  |   |        |  |   |       
|                                                    |  |                           |        |                          |  
|Total research and development expenses             |  | $                         | 11,505 |                          | $ | 13,677                  |  | $    | 32,731 |  | $ | 41,394 |  |   |       
|                                                    |  |                           |        |                          |   |                         |  |      |        |  |   |        |  |   |       



|* | Roche is responsible for all of the expenses associated with the research and development of RG7128.
|- | ----------------------------------------------------------------------------------------------------

We will continue to make determinations as to which programs to pursue and how much funding to direct to each program on an ongoing
basis. These determinations will be made in response to the scientific and clinical success of each product candidate, as well as an ongoing assessment as to the product candidates commercial potential. We do not believe that it is possible at
this time to accurately project total program-specific expenses through commercialization for any of our product candidates, as there are numerous factors associated with the successful commercialization of any of our product candidates, including
future trial design and various regulatory requirements such as competitive final product labeling and reasonable risk management programs, many of which cannot be determined with accuracy at this time based on our stage of development. Product
candidates that may appear promising at early stages of development may not reach the market for a number of reasons. For example, product candidates may be found ineffective or may cause harmful side effects during clinical trials, may take longer
to progress through clinical trials than anticipated, may fail to receive necessary regulatory approvals, or may prove impracticable to manufacture in commercial quantities at reasonable cost and with acceptable quality. The lengthy process of
seeking FDA and other regulatory agency approvals requires the expenditure of substantial resources. Any failure or delay in obtaining regulatory approvals could materially adversely affect our product development effort and financial condition.
Because of these and other risks and uncertainties, we cannot predict when or whether we will successfully complete the development of any of our product candidates or the ultimate product development cost or whether we will obtain any approval
required by the FDA or other regulatory agencies on a timely basis, if at all.

As we obtain results from clinical trials, we
may elect to discontinue or delay preliminary studies or clinical trials for a product candidate or development program in order to focus our resources on more promising product candidates or programs. As of December 31, 2009, we had completed
the termination of our Phase 3 registration studies of clevudine.

General and Administrative Expenses

General and administrative expenses consist primarily of compensation for employees in executive and operational
functions, including accounting, finance, legal, business development, investor relations, information technology, and human resources. Other significant general and administration costs include facilities costs and professional fees for outside
accounting and legal services, travel, insurance premiums, and depreciation.



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Results of Operations

Three and Nine Months Ended June 30, 2010 and 2009

Revenues. Revenues decreased to $0.2 million during the quarter ended June 30, 2010 from $10.5 million during the quarter
ended June 30, 2009, and decreased to $0.8 million during the nine months ended June 30, 2010 from $12.9 million during the nine months ended June 30, 2009. Revenues during each three and nine month period include amortization of
up-front and subsequent collaborative and license payments received from Roche previously recorded as deferred revenue. Revenues during the three and nine months ended June 30, 2009 also include a $10.0 million milestone payment received from
Roche for initiating a Phase 2b study of RG7128. Revenues during the nine months ended June 30, 2009 also include $1.4 million of non-recurring research and development payments from Roche for activities related to holding and maintaining the
Investigational New Drug (IND) application for RG7128.

The following is a reconciliation between cash payments
received under contract revenue agreements and contract revenues reported:



|                         |  |                            |     |                           |   |        |  |      |     |  |   |       
|------------------------ |  | -------------------------- | --- | ------------------------- | - | ------ |  | ---- | --- |  | - | ------
|                         |  | Three Months EndedJune 30, |     | Nine Months EndedJune 30,
|                         |  | 2010                       |     | 2009                      |   | 2010   |  | 2009
|                         |  | (In thousands)             |     | (In thousands)           
|Cash received/receivable |  | $                          | 3   |                           | $ | 10,037 |  | $    | 30  |  | $ | 11,475
|Deferred                 |  |                            |    |                           |   |       |  |      |    |  |   |      
|Amortization             |  |                            | 246 |                           |   | 464    |  |      | 739 |  |   | 1,393 
|                         |  |                            |     |                           |   |        |  |      |     |  |   |       
|Revenues                 |  | $                          | 249 |                           | $ | 10,501 |  | $    | 769 |  | $ | 12,868
|                         |  |                            |     |                           |   |        |  |      |     |  |   |       

Research and Development Expenses. Research and
development expenses decreased to $11.5 million during the quarter ended June 30, 2010 from $13.7 million during the quarter ended June 30, 2009. This net decrease of $2.2 million consists of a $7.1 million decrease in clinical
trial expenses for clevudine resulting from our voluntary termination of our Phase 3 registration studies of clevudine, which was completed as of December 31, 2009. Mostly offsetting this $7.1 million decrease was an increase of $2.2 million
for preclinical and clinical trial costs for PSI-7977, a $1.3 million increase in preclinical trial costs for PSI-938, and a $1.3 million increase in preclinical and clinical trial costs for our other third generation HCV product candidate, PSI-661.

Research and development expenses decreased to $32.7 million during the nine months ended June 30, 2010 from $41.4
million during the nine months ended June 30, 2009. This net decrease of $8.7 million consists of a $22.1 million decrease in clinical trial expenses for clevudine resulting from our voluntary termination of our Phase 3 registration
studies of clevudine, which was completed as of December 31, 2009. Mostly offsetting this $22.1 million decrease was an increase of $6.6 million for preclinical and clinical trial costs for PSI-7977, a $3.6 million increase in preclinical trial
costs for PSI-661, and a $3.2 million increase in preclinical and clinical trial costs for our other third generation HCV product candidate, PSI-938.

General and Administrative Expenses. General and administrative expenses were $4.2 million during the quarter ended
June 30, 2010, an increase of $1.2 million from $3.0 million during the quarter ended June 30, 2009. The increase of $1.2 million was due primarily to an increase of $1.4 million in legal expenses incurred in connection with our defense
against the Demand for Arbitration and Relief (see Part II., Item 1.Legal Proceedings, for additional information). Partially offsetting this $1.4 million increase were reductions of $0.1 million in compensation expense and $0.1 million
in other administrative expenses.

General and administrative expenses were $12.1 million during the nine months ended
June 30, 2010, an increase of $2.1 million from $10.0 million during the nine months ended June 30, 2009. The increase of $2.1 million was due primarily to an increase of $3.1 million in legal expenses incurred in connection with our
defense against the Demand for Arbitration and Relief (see Part II., Item 1.Legal Proceedings, for additional information). Partially offsetting this $3.1 million increase were reductions of $0.5 million in marketing expense, $0.2 million
of consulting expense, $0.2 million of insurance expense, and $0.1 million of compensation expense.



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Investment Income. Investment income decreased to $1 thousand during the quarter
ended June 30, 2010 from $38 thousand during the quarter ended June 30, 2009, and decreased to $6 thousand during the nine months ended June 30, 2010 from $205 thousand during the nine months ended June 30, 2009. The
decrease was due primarily to lower rates of return on the average invested cash balances during 2010 compared to 2009.

Interest Expense. Interest expense decreased to $0.6 million during the quarter ended June 30, 2010 from $0.8 million during
the quarter ended June 30, 2009, and decreased to $1.9 million during the nine months ended June 30, 2010 from $2.4 million during the nine months ended June 30, 2009. The decrease in interest expense was due to lower levels of
long-term debt during 2010 compared to 2009.

Liquidity and Capital Resources

Since our inception, we have funded our operations primarily through public and private offerings of our equity securities, payments
received under our collaboration agreements, and borrowings under our Loan Agreement. We have raised approximately $309.4 million in net proceeds from sales of our equity securities, and borrowed a total of $23.3 million under our Loan Agreement
entered into on September 30, 2007. At June 30, 2010, we held $144.4 million in cash and cash equivalents and have invested substantially all of our available cash and cash equivalents in a mutual fund, which invests in short-term U.S.
Treasury and Agency Obligations, or in a money fund account. Borrowings under our Loan Agreement were $14.1 million as of June 30, 2010.

Net cash used in operating activities was $42.9 million during the nine months ended June 30, 2010 compared to $36.5 million during
the nine months ended June 30, 2009. The $6.4 million increase in net cash used in operating activities during the nine months ended June 30, 2010, as compared to the nine months ended June 30, 2009, was due primarily to higher
operating expenses of $4.7 million and unfavorable changes in our working capital of $1.7 million during the nine months ended June 30, 2010 compared to the nine months ended June 30, 2009.

Net cash used in investing activities of $0.5 million during the nine months ended June 30, 2010 was for the purchase of equipment
primarily for our lab operations. Net cash provided by investing activities of approximately $0.3 million during the nine months ended June 30, 2009 resulted from the maturity of $0.5 million of short-term investments that was partially offset
by $0.2 million of purchases of equipment.

Net cash provided by financing activities was $129.4 million during the nine
months ended June 30, 2010, compared to $45.8 million during the nine months ended June 30, 2009. The net cash provided by financing activities during the nine months ended June 30, 2010 consisted of $133.9 million of net proceeds
from issuances of common stock and $1.4 million in proceeds from the exercise of stock options that were partially offset by $6.0 million of principal payments on long-term debt. Net cash provided by financing activities during the nine months ended
June 30, 2009 consisted of $43.4 million in net proceeds from the issuance of common stock, borrowings of long-term debt of $3.3 million, and proceeds from the exercise of stock options of $0.6 million, that were partially offset by principal
payments on long-term debt and capital lease obligations of $1.5 million.

On September 30, 2007, we entered into a Loan
Agreement that allowed us to borrow up to $30.0 million in $10.0 million increments. We borrowed the first and second $10.0 million increments by signing two Secured Promissory Notes (Notes A and B) on October 5, 2007 and
March 28, 2008. Notes A and B bear interest at 12%. On December 12, 2008, we amended the Loan Agreement and borrowed $3.3 million by signing a Secured Promissory Note (Note C). Note C bears interest at 12.5%. Notes A, B, and C
are to be repaid over a 45-month period with the first 15 monthly payments representing interest only followed by 30 equal monthly payments of principal and interest. The principal monthly payments on each of the notes begin and end as follows:



|       |  |                |  |                
|------ |  | -------------- |  | ---------------
|Note   |  | Begin          |  | End            
|Note A |  | March 1, 2009  |  | August 1, 2011 
|Note B |  | August 1, 2009 |  | January 1, 2012
|Note C |  | May 1, 2010    |  | October 1, 2012

Prepayment of the
loans made pursuant to the Loan Agreement is subject to penalty and substantially all of our tangible and intangible assets (except for intellectual property) are pledged as collateral for the Loan Agreement. Future total principal repayments of the
three Notes amount to $1.5 million during the fourth quarter of fiscal 2010, $9.5 million in fiscal 2011, $3.0 million in fiscal 2012, and $0.1 million in fiscal 2013. There are no additional borrowings available under the Loan Agreement.



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Under the Loan Agreement, we agreed that in the event our market capitalization is below
$90.0 million for 15 consecutive days in which the principal market for our common stock is open for trading to the public, we will be required to repay 50% of the then outstanding principal balance of the loans. We further agreed that in the event
our market capitalization is below $40.0 million for 15 consecutive days in which the principal market for our common stock is open for trading to the public, we will be required to repay all of the then outstanding principal balance of the loans.

The Loan Agreement also contains covenants that, among other things, require us to obtain consent from the lender prior to
paying dividends, making certain investments, changing the nature of our business, assuming or guaranteeing the indebtedness of another entity or individual, selling or otherwise disposing of a substantial portion of our assets, or merging or
consolidating with another entity.

Developing drugs, conducting clinical trials and commercializing products is expensive and
we will need to raise additional funds to achieve our strategic objectives. Although we believe our existing cash resources will be sufficient to fund our projected cash requirements for at least the next 12 months, we will require significant
additional financing in the future to complete our clinical trials for PSI-7977, PSI-938, and PSI-661, to fund our portion, if any, of the cost of clinical trials for RG7128 completed outside of the territories licensed by Roche, and to fund our
other operations. Additional financing may not be available on acceptable terms, if at all. Our future capital requirements will depend on many factors, including:



| |  |  | the progress and costs of our preclinical studies, clinical trials, and other research and development activities;
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | the scope, prioritization, and number of our clinical trials and other research and development programs;
| | - |  | ---------------------------------------------------------------------------------------------------------



| |  |  | the amount of cash we receive under our existing collaboration agreement and any future collaboration agreements;
| | - |  | -----------------------------------------------------------------------------------------------------------------



| |  |  | the costs of the development and expansion of our operational infrastructure;
| | - |  | -----------------------------------------------------------------------------



| |  |  | the costs and timing of obtaining regulatory approval of our product candidates;
| | - |  | --------------------------------------------------------------------------------



| |  |  | the ability of our collaborators to achieve development milestones, marketing approval, and other events or developments under our collaboration
agreements;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs of filing, prosecuting, enforcing, and defending patent claims and other intellectual property rights;
| | - |  | ----------------------------------------------------------------------------------------------------------------



| |  |  | the costs and timing of securing manufacturing arrangements for clinical or commercial production;
| | - |  | --------------------------------------------------------------------------------------------------



| |  |  | the costs of establishing sales and marketing capabilities or contracting with third parties to provide these capabilities for us;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs of acquiring or undertaking development and commercialization efforts for any future product candidates;
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | the magnitude of our general and administrative expenses; and
| | - |  | -------------------------------------------------------------



| |  |  | any costs that we may incur under current and future licensing arrangements relating to our product candidates.
| | - |  | ---------------------------------------------------------------------------------------------------------------

Until we can generate significant continuing revenues, we expect to satisfy our future cash needs through payments received under our
collaborations, debt or equity financings, or by out-licensing product candidates. We cannot be certain that additional funding will be available to us on acceptable terms, or at all. If funds are not available, we may be required to delay, reduce
the scope of, or eliminate one or more of our research or development programs or our commercialization efforts.



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Contractual Obligations and Commitments

We entered into an operating lease for office and laboratory space located in Princeton, New Jersey through May 22, 2015. We also
entered into an operating lease for office space located in Durham, North Carolina through April 2011. We executed three secured promissory notes totaling $23.3 million; $10.0 million in October 2007, $10.0 million in March 2008, and $3.3 million in
December 2008. The secured promissory notes require payments of interest only for the first 15 months followed by 30 equal monthly payments of principal and interest. As of June 30, 2010, future payments under the three promissory notes and
minimum future payments under non-cancellable operating leases are as follows:



|                              |  |                |        |                        |   |           |  |           |       |              |   |     |  |   |  
|----------------------------- |  | -------------- | ------ | ---------------------- | - | --------- |  | --------- | ----- | ------------ | - | --- |  | - | -
|                              |  |                |        | Payments Due By Period
|                              |  | Total          |        | Less than1 year        |   | 1-3 Years |  | 4-5 Years |       | After5 Years
|                              |  | (In thousands)
|Debt obligations              |  |                |        |                        |   |           |  |           |       |              |   |     |  |   |  
|Debt maturities               |  | $              | 14,100 |                        | $ | 8,934     |  | $         | 5,166 |              | $ |    |  | $ | 
|Contractual interest          |  |                | 1,420  |                        |   | 1,150     |  |           | 270   |              |   |    |  |   | 
|Capital lease obligations     |  |                |        |                        |   |           |  |           |       |              |   |     |  |   |  
|Debt maturities               |  |                |       |                        |   |          |  |           |      |              |   |    |  |   | 
|Contractual interest          |  |                |       |                        |   |          |  |           |      |              |   |    |  |   | 
|Operating leases              |  |                | 4,076  |                        |   | 824       |  |           | 2,506 |              |   | 746 |  |   |  
|Purchase obligations          |  |                |       |                        |   |          |  |           |      |              |   |    |  |   | 
|                              |  |                |        |                        |   |           |  |           |       |              |   |     |  |   |  
|                              |  |                |        |                        |  
|Total contractual obligations |  | $              | 19,596 |                        | $ | 10,908    |  | $         | 7,942 |              | $ | 746 |  | $ | 
|                              |  |                |        |                        |   |           |  |           |       |              |   |     |  |   |  

The above contractual obligations table does not
include amounts for milestone payments related to development, regulatory, or commercialization events to licensors or collaboration partners, as the payments are contingent on the achievement of these milestones, which we have not achieved. Under
our license agreement with Emory University for Racivir, we agreed to pay Emory University up to an aggregate of $1.0 million in future marketing milestone payments.

Off-Balance Sheet Transactions

To date, we have not had any relationships with unconsolidated entities or financial partnerships, such as entities referred to as
structured finance or special purpose entities, which are established for the purpose of facilitating off-balance sheet arrangements or other contractually narrow or limited purposes.

Critical Accounting Policies and Estimates

Our discussion and analysis of our financial condition and results of operations is based on our financial statements, which have been
prepared in accordance with generally accepted accounting principles in the United States. The preparation of these financial statements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, and
expenses and related disclosures. We review our estimates on an ongoing basis. We base our estimates on historical experience and on various other assumptions that we believe to be reasonable under the circumstances. Our actual results may differ
substantially from these estimates under different assumptions or conditions. Our significant accounting policies are described in more detail in Note 2 of the Notes to Financial Statements included elsewhere in this Quarterly Report on Form 10-Q;
however, we believe that the following accounting policies are critical to the judgments and estimates used in the preparation of our financial statements.



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Revenue Recognition

We recognize revenues when all of the following four criteria are present: persuasive evidence of an arrangement exists; delivery has
occurred or services have been rendered; the fee is fixed or determinable; and collectability is reasonably assured. For arrangements that involve the delivery or performance of multiple products, services, and/or rights to use assets, the elements
are divided into separate units of accounting if certain criteria are met, including whether the delivered element has stand-alone value to the collaborator and whether there is objective and reliable evidence of the fair value of the undelivered
obligation(s). The consideration received is allocated among the separate units either on the basis of each units fair value or using the residual method and the applicable revenue recognition criteria are applied to each of the separate
units.

Our revenues are primarily related to our collaboration agreement with Roche. This agreement provides for various
types of payments to us, including non-refundable upfront license fees, research and development payments, and milestone payments.

Where we have continuing performance obligations under the terms of a collaboration agreement, non-refundable upfront license payments
received upon contract signing are recorded as deferred revenue and recognized as revenue as the related activities are performed. The period over which these activities are to be performed is based upon our estimate of the development period.
Changes in our estimate could change the period over which revenues are recognized. Research and/or development payments are recognized as revenues as the related research and/or development activities are performed and when we have no continuing
performance obligations related to the research and development payment received.

We recognize revenue from milestone
payments when earned, provided that (i) the milestone event is substantive and its achievability was not reasonably assured at the inception of the agreement and (ii) we do not have ongoing performance obligations related to the
achievement of the milestone earned. Milestone payments are considered substantive if all of the following conditions are met: the milestone payment is non-refundable; achievement of the milestone was not reasonably assured at the inception of the
arrangement; substantive effort is involved to achieve the milestone; and the amount of the milestone appears reasonable in relation to the effort expended, the other milestones in the arrangement and the related risk associated with the achievement
of the milestone. Any amounts received under the agreements in advance of performance, if deemed substantive, are recorded as deferred revenue and recognized as revenue as we complete our performance obligations.

Where we have no continuing involvement under a collaborative arrangement, we record nonrefundable license fee revenues when we have the
contractual right to receive the payment, in accordance with the terms of the license agreement, and records milestones upon appropriate notification to us of achievement of the milestones by the collaborative partner.

Deferred revenue associated with a non-refundable payment received under a collaborative agreement that is terminated prior to its
completion results in an immediate recognition of the deferred revenues.

Accrued Expenses

We are required to estimate accrued expenses as part of our process of preparing financial statements. This process involves estimating
the level of service performed on our behalf and the associated cost incurred in instances where we have not been invoiced or otherwise notified of actual costs. Examples of areas in which subjective judgments may be required include costs
associated with services provided by contract organizations for preclinical development, clinical trials and manufacturing of clinical materials. We account for expenses associated with these external services by determining the total cost of a
given study based on the terms of the related contract. We accrue for costs incurred as the services are being provided by monitoring the status of the trials and the invoices received from our external service providers. In the case of clinical
trials, the estimated cost normally relates to the projected costs of having subjects enrolled in our trials, which we recognize over the estimated term of the trial according to the number of patients enrolled in the trial on an ongoing basis,
beginning with patient enrollment. As actual costs become known to us, we adjust our accruals. To date, the number of clinical trials and related research service agreements has been relatively limited and our estimates have not differed
significantly from the actual costs incurred. We expect, however, as clinical trials for PSI-7977, PSI-938, and PSI-661 advance, that our estimated accruals for clinical and research services will be more material to our operations in future
periods.



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Stock-based Compensation

We recognize stock compensation expense for awards of equity instruments to employees and directors based on the grant-date fair value of
those awards (with limited exceptions). The grant-date fair value of the award is recognized as compensation expense over the life of the equity instruments issued. Equity instruments granted to consultants are periodically valued and recorded as
stock compensation expense as the equity instrument vests.

Stock-based compensation expense is included in both research and
development expenses and in general and administrative expenses in the statements of operations and comprehensive net income (loss). Since our stock was not publicly traded prior to April 27, 2007, the expected volatility was calculated for
each equity award granted based on the peer method. We identified companies that traded publicly within the pharmaceutical industry that had similar SIC codes, employee count and revenues. Prior to October 1, 2006, we had chosen the
weekly high price volatility for these companies for a period of five years. Subsequent to October 1, 2006, we have used the weekly high price for these companies for a period of six years to coincide with the expected term.

Recently Issued Accounting Pronouncements

In October 2009, the FASB issued ASU No. 2009-13, Multiple-Deliverable Revenue Arrangements. This ASU provides guidance on
accounting for multiple-deliverable revenue arrangements that provides principles and application guidance on whether multiple deliverables exist, how the arrangement should be separated and the consideration allocated. This guidance requires an
entity to allocate revenue in an arrangement using estimated selling prices of deliverables if a vendor does not have vendor-specific objective evidence or third-party evidence of selling price. The update eliminates the use of the residual method
and requires an entity to allocate revenue using the relative selling price method and also significantly expands the disclosure requirements for multiple-deliverable revenue arrangements. This guidance should be applied on a prospective basis for
revenue arrangements entered into or materially modified in fiscal years beginning on or after June 15, 2010, with earlier application permitted. We are currently evaluating the impact, if any, of adopting this guidance on our financial
statements.

In April 2010, the FASB issued ASU No. 2010-17, Revenue Recognition  Milestone Method.
This ASU provides guidance on the criteria that should be met for determining whether the milestone method of revenue recognition is appropriate. Under the milestone method of revenue recognition, consideration that is contingent upon achievement of
a milestone in its entirety can be recognized as revenue in the period in which the milestone is achieved only if the milestone meets all criteria to be considered substantive. This standard provides the criteria to be met for a milestone to be
considered substantive which includes that: a) performance consideration earned by achieving the milestone be commensurate with either performance to achieve the milestone or the enhancement of the value of the item delivered as a result of a
specific outcome resulting from performance to achieve the milestone; and b) relate to past performance and be reasonable relative to all deliverables and payment terms in the arrangement. This standard is effective on a prospective basis for
milestones in fiscal years beginning on or after June 15, 2010. Although we are still evaluating the impact of this standard, we do not expect its adoption to have a material impact on our financial position or the results of our operations.



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|ITEM 4. | CONTROLS AND PROCEDURES
|------- | -----------------------

Evaluation of Disclosure Controls and Procedures

We carried out an evaluation, under the supervision and with the participation of our management, including our principal executive
officer and principal financial officer, of the effectiveness of the design and operation of our disclosure controls and procedures (as such term is defined under Rule 13a-15(e) promulgated under the Securities Exchange Act of 1934, as amended
(Exchange Act), as of June 30, 2010. Based on that evaluation, management concluded that these controls and procedures are effective to ensure that information required to be disclosed by us in reports that we file or submit under
the Exchange Act is recorded, processed, summarized and reported as specified in SEC rules and forms.

Our disclosure controls
and procedures are designed to ensure that information required to be disclosed by us in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the rules and
forms of the SEC. These disclosure controls and procedures include, among other things, controls and procedures designed to ensure that information required to be disclosed by us in the reports that we file under the Exchange Act is accumulated and
communicated to our management, including our principal executive officer and principal financial officer, as appropriate to allow timely decisions regarding required disclosure.

Changes in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting during the three months ended June 30, 2010 that have
materially affected, or are reasonably likely to materially affect our internal control over financial reporting.

PART II. OTHER INFORMATION



|ITEM 1. | LEGAL PROCEEDINGS
|------- | -----------------

On
July 28, 2009, Emory University and University of Georgia Research Foundation, Inc. (Claimants) filed a Demand for Arbitration and Relief (the Demand) with the American Arbitration Association in Atlanta, Georgia (the
Emory Arbitration), claiming certain payments and seeking specific performance under the Companys January 8, 2004 license agreement with Claimants (the Emory License).

The Demand alleges that payments Pharmasset has received under the Roche collaboration agreement are subject to the Emory License and
that Pharmasset has not paid fees to Claimants based on such payments. In addition, the Demand alleges that Pharmasset has not complied with certain terms and conditions of the Emory License and that other Pharmasset product candidates are, or will
be, covered by the Emory License. The Demand requests, among other things, specific performance of the Emory License, including the payment of license fees related to past payments received by Pharmasset. The Companys response to the Demand
was filed on August 14, 2009. The Company denies these allegations and intends to vigorously defend itself against the Demand.



|ITEM 1A. | RISK FACTORS
|-------- | ------------

There have been no material changes to the risk factors discussed in Part I, Item 1A. Risk Factors,
in our Annual Report on Form 10-K for the year ended September 30, 2009 (Form 10-K). You should carefully consider the risks described in our Form 10-K, which could materially affect our business, financial condition or future
results. The risks described in our Form 10-K are not the only risks we face. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially adversely affect our business, financial
condition, and/or operating results. If any of the risks actually occur, our business, financial condition, and/or results of operations could be negatively affected.



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##### Table of Contents

|ITEM 6. | EXHIBITS
|------- | --------



|              |  |                                       
|------------- |  | --------------------------------------
|ExhibitNumber |  | Description                           
|              | 
|31.1*         |  | Rule 13a-14(a)/15d-14(a) Certification
|              | 
|31.2*         |  | Rule 13a-14(a)/15d-14(a) Certification
|              | 
|32.1*         |  | Section 1350 Certification            
|              | 
|32.2*         |  | Section 1350 Certification            

* - Filed herewith.



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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its
behalf by the undersigned thereunto duly authorized.



|                     |  |  |  |                  |  |                                                                                                  
|-------------------- |  |  |  | ---------------- |  | -------------------------------------------------------------------------------------------------
|                     |  |  |  | PHARMASSET, INC.
|                     |  |  | 
|Date: August 9, 2010 |  |  |  | By:              |  | /s/ Kurt Leutzinger                                                                              
|                     |  |  |  |                  |  | Kurt Leutzinger
Chief Financial Officer
(duly authorized officer and principal financial officer)



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EXHIBIT INDEX



|              |  |                                       
|------------- |  | --------------------------------------
|ExhibitNumber |  | Description                           
|              | 
|31.1          |  | Rule 13a-14(a)/15d-14(a) Certification
|              | 
|31.2          |  | Rule 13a-14(a)/15d-14(a) Certification
|              | 
|32.1          |  | Section 1350 Certification            
|              | 
|32.2          |  | Section 1350 Certification            



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