Exhibit 21

SUBSIDIARIES OF ORIENT-EXPRESS HOTELS LTD.

|                                     |                                                                           | Jurisdiction of Organization                                              
|------------------------------------ | ------------------------------------------------------------------------- | --------------------------------------------------------------------------
|80 Westcliff (Pty) Ltd.              |                                                                           | South Africa                                                              
|Alberghiera Fiesolana S.p.A.         |                                                                           | Italy                                                                     
|                                     | Byblos S.r.l.
(subsidiary of Alberghiera Fiesolana S.p.A.)                |                                                                           
|Compania Hoteis Palace               |                                                                           | Brazil                                                                    
|Hotel Cipriani S.p.A.                |                                                                           | Italy                                                                     
|                                     | Subsidiaries of Hotel Cipriani S.p.A.                                     |                                                                           
|                                     | Venice Simplon-Orient-Express Ltd.                                        |                                                                           
|                                     |                                                                           | Subsidiaries of Venice Simplon-Orient-Express Ltd.                        
|                                     |                                                                           | Northern Belle Ltd.                                                       
|                                     |                                                                           | Venice Simplon-Orient-Express Deutschland GmbH                            
|                                     |                                                                           | Venice Simplon-Orient-Express Voyages S.A.                                
|                                     | Venice Simplon-Orient-Express Servizi S.r.l.                              |                                                                           
|Hotelapa Investimento Hoteleiro S.A. |                                                                           | Portugal                                                                  
|Hotel Splendido S.r.l.               |                                                                           | Italy                                                                     
|                                     | Subsidiaries of Hotel Splendido S.r.l.                                    |                                                                           
|                                     | Mirna S.r.l.                                                              |                                                                           
|                                     |                                                                           | Collection Venice Simplon-Orient-Express Ltd. (subsidiary of Mirna S.r.l.)
|                                     | Société de la Cité S.A.                                                   |                                                                           
|La Residencia Ltd.                   |                                                                           | U.K.                                                                      
|                                     | Son Moragues S.A. (subsidiary of La Residencia Ltd.)                      |                                                                           
|La Samanna S.A.S.                    |                                                                           | France                                                                    
|Leisure Holdings Asia Ltd.           |                                                                           | Bermuda                                                                   
|                                     | Subsidiaries of Leisure Holdings Asia Ltd.                                |                                                                           
|                                     | Myanmar Hotels and Cruises Ltd.                                           |                                                                           
|                                     | Vessel Holdings 2 Ltd.                                                    |                                                                           
|Lilianfels Hotel Ltd.                |                                                                           | Bermuda                                                                   
|                                     | Lilianfels Blue Mountains Pty. Ltd. (subsidiary of Lilianfels Hotel Ltd.) |                                                                           
|Miraflores Ventures Ltd.             |                                                                           | B.V.I.                                                                    
|                                     | Plan Costa Maya, S.A. de C.V. (subsidiary of Miraflores Ventures Ltd.)    |                                                                           
|MPP S.A.                             |                                                                           | Peru                                                                      
|                                     | Inversiones Malecon de la Reserva S.A. (subsidiary of MPP S.A.)           |                                                                           
|Nara Tahiti S.A.                     |                                                                           | French Polynesia                                                          
|Observatory Hotel Ltd.               |                                                                           | Bermuda                                                                   
|                                     | Observatory Hotel Pty. Ltd. (subsidiary of Observatory Hotel Ltd.)        |                                                                           
|OEH Oxford Ltd.                      |                                                                           | Bermuda                                                                   
|                                     | Le Manoir Ltd. (subsidiary of OEH Oxford Ltd.)                            |                                                                           
|                                     | Le Manoir Holdings Ltd. (subsidiary of Le Manoir Ltd.)                    |                                                                           
|                                     | Blanc Restaurants Ltd. (subsidiary of Le Manoir Holdings Ltd.)            |                                                                           
|OEH Peru Ltd.                        |                                                                           | Bermuda                                                                   
|OEH Spain Ltd.                       |                                                                           | Bermuda                                                                   
|                                     | Nomis Mallorcan Investments S.A. (subsidiary of OEH Spain Ltd.)           |                                                                           
|Orient-Express Holdings 1 Ltd.       |                                                                           | Bermuda                                                                   
|                                     |                                                                           |                                                                           

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|Orient-Express Hotels Inc.           |                                                                                 | Delaware                                                                     
|------------------------------------ | ------------------------------------------------------------------------------- | -----------------------------------------------------------------------------
|                                     | Subsidiaries of Orient-Express Hotels Inc.                                      |                                                                              
|                                     | '21' Club Properties Inc.                                                       |                                                                              
|                                     |                                                                                 | '21' Club Inc. (subsidiary of '21' Club Properties Inc.)                     
|                                     | Charleston Place Holdings Inc.                                                  |                                                                              
|                                     | Mountbay Holdings Inc.                                                          |                                                                              
|                                     |                                                                                 | Subsidiaries of Mountbay Holdings Inc.                                       
|                                     |                                                                                 | Inn at Perry Cabin Corporation                                               
|                                     |                                                                                 | Keswick Hall Inc.                                                            
|                                     | Orient-Express Services Inc.                                                    |                                                                              
|                                     |                                                                                 | Subsidiaries of Orient-Express Services Inc.                                 
|                                     |                                                                                 | Keswick Golf Club Inc.                                                       
|                                     |                                                                                 |                                                                              
|                                     |                                                                                 | Luxury Reservation Services Inc.                                             
|                                     | Orient-Express Hotels Louisiana Inc.                                            |                                                                              
|                                     | Venice Simplon-Orient-Express Inc.                                              |                                                                              
|                                     |                                                                                 | Orient-Express Travel Inc. (subsidiary of Venice Simplon-Orient-Express Inc.)
|                                     | Windsor Court Hotel Inc.                                                        |                                                                              
|Orient-Express Hotels U.K. Ltd.      |                                                                                 | U.K.                                                                         
|                                     | Subsidiaries of Orient-Express Hotels U.K. Ltd.                                 |                                                                              
|                                     | Horatio Properties Ltd.                                                         |                                                                              
|                                     |                                                                                 | Mount Nelson Hotel Ltd. (subsidiary of Horatio Properties Ltd.)              
|                                     | Orient-Express Services Ltd.                                                    |                                                                              
|Orient-Express Spanish Holdings S.L. |                                                                                 | Spain                                                                        
|                                     | Orient-Express Madrid S.L. (subsidiary of Orient-Express Spanish Holdings S.L.) |                                                                              
|Reid's Hoteis Lda.                   |                                                                                 | Portugal                                                                     
|                                     | Island Hotel (Madeira) Ltd. (subsidiary of Reid's Hoteis Lda.)                  |                                                                              
|                                     | Game Viewers (Pty) Ltd. (subsidiary of Island Hotel (Madeira) Ltd.)             |                                                                              
|                                     | Gametrackers (Botswana) (Pty) Ltd. (subsidiary of Game Viewers (Pty) Ltd.)      |                                                                              
|Sea Containers Peru Rail Ltd.        |                                                                                 | Bermuda                                                                      
|Windsor New Orleans Properties Ltd.  |                                                                                 | Bermuda                                                                      
|                                     | Windsor Great Park Inc. (subsidiary of Windsor New Orleans Properties Ltd.)     |                                                                              
|                                     | Windsor Court Hotel Limited Partnership (subsidiary of Windsor Great Park Inc.) |                                                                              

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