Exhibit 10.1
 *
    
    Confidential Treatment has been
requested for the marked portions
of this exhibit pursuant to Rule
24B-2 of the Securities Exchange
Act of 1934, as amended.
 THIRD AMENDMENT
 between
 TRUBION PHARMACEUTICALS, INC.
 and
 LONZA SALES AG
(successor in interest to Lonza Biologics, Inc., by way of novation)
 to
 MANUFACTURING SERVICES AGREEMENT
dated November 21, 2005




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##### 



THIRD AMENDMENT TO MANUFACTURING SERVICES AGREEMENT
  (1)
    
    Trubion Pharmaceuticals, Inc. (Trubion) and(2)
    
    Lonza Sales AG (Lonza Sales)
   February
2010 TRU-016 Run
 Exhibit 1 Schedule
2-016
 Schedule 3-016
 3.1.
    
    A row containing the following text and format shall be inserted at the bottom of the
table that appears under the sentence In consideration for Lonza carrying out the Services
as detailed in Schedule 2-016, Trubion shall pay Lonza as follows::
 Stage 11
    
    [*]
    
    [*]Stage 12
    
    [*]
    
    [*]
 3.2.
    
    Following the final line of text that appears under the heading Payment by Trubion of
the Price for each Stage shall be made against Lonzas invoices as follows: the following
text shall be inserted:For Stage 11
    *Confidential Treatment Requested.
 2




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##### 



For Stage 12
     Exhibit B
 Exhibit
D-016-2
      TRUBION PHARMACEUTICALS, INC.
    
    
    
    LONZA SALES AGBy:
    
    /s/ KENDALL M. MOHLER
    
    
    
    By:
    
    /s/ GERRY KENNEDYName:
    
    Kendall M. Mohler
    
    
    
    
    
    Name:
    
    Gerry KennedyTitle:
    
    CSO, SVP & R&D
    
    
    
    
    
    Title:
    
    Authorized SignatoryDate:
    
    2/22/10
    
    
    
    
    
    Date:
    
    3 March 2010LONZA SALES AGBy:
    
    /s/ STEVE FLATMANName:
    
    Steve FlatmanTitle:
    
    Authorized SignatoryDate:
    
    3 March 2010
 *Confidential Treatment Requested.
 3




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##### 



Exhibit 1
 Stage 11  [*]
       [*][*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
     
 
 
 
 
 
            *Confidential Treatment Requested.
 4




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##### 



*Confidential Treatment Requested.
 5




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##### 



Stage 12  [*]
        [*]
    
    [*][*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
    [*]
    
 
 
 
 
 
 
 
          *Confidential Treatment Requested.
 6




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##### 



*Confidential Treatment Requested.
 7




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##### 



Trubions Primary Business Coordinator
    
    [*]Trubions Backup Business Coordinator
    
    [*]Trubions Primary Technical Coordinator
    
    [*]Trubions Backup Technical Coordinator
    
    [*]
  Lonzas Primary Business Coordinator
    
    [*]Lonzas Backup Business Coordinator
    
    [*]Lonzas Primary Technical Coordinator
    
    [*]Lonzas Backup Technical Coordinator
    
    [*]
 *Confidential Treatment Requested.
 8




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##### 



[*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*][*]
    
    [*]
    
    [*]
 *Confidential Treatment Requested.
 9