Exhibit 21

SUBSIDIARIES OF ORIENT EXPRESS HOTELS LTD.

|                                     |                                                                          | Jurisdiction of Organization                                  
|------------------------------------ | ------------------------------------------------------------------------ | --------------------------------------------------------------
|80 Westcliff (Pty) Ltd.              |                                                                          | South Africa                                                  
|Compania Hoteis Palace               |                                                                          | Brazil                                                        
|Cupecoy Village Real Estate NV       |                                                                          | St. Maarten                                                   
|Cupecoy Village Development NV       |                                                                          | St. Maarten                                                   
|European Cruises Ltd.                |                                                                          | U.K.                                                          
|                                     | Crosieres Orex S.A. (subsidiary of European Cruises Ltd.)                |                                                               
|Haggerton Holdings Ltd.              |                                                                          | Cyprus                                                        
|Hotelapa Investimento Hoteliero S.A. |                                                                          | Portugal                                                      
|La Cabana de Buenos Aires S.A.       |                                                                          | Argentina                                                     
|La Residencia Ltd.                   |                                                                          | U.K.                                                          
|                                     | Son Moragues S.A. (subsidiary of La Residencia Ltd.)                     |                                                               
|La Samanna S.A.S.                    |                                                                          | France                                                        
|Leisure Holdings Asia Ltd.           |                                                                          | Bermuda                                                       
|                                     | Subsidiaries of Leisure Holdings Asia Ltd.                               |                                                               
|                                     | Myanmar Hotels and Cruises Ltd.                                          |                                                               
|                                     | Vessel Holdings 2 Ltd.                                                   |                                                               
|Lilianfels Hotel Ltd.                |                                                                          | Bermuda                                                       
|                                     | Lilianfels Blue Mountain Pty. Ltd. (subsidiary of Lilianfels Hotel Ltd.) |                                                               
|Miraflores Ventures Ltd.             |                                                                          | B.V.I.                                                        
|                                     | Plan Costa Maya S.A. de C.V. (subsidiary of Miraflores Ventures Ltd.)    |                                                               
|MPP S.A.                             |                                                                          | Peru                                                          
|                                     | Inversiones Malecon de la Reserva S.A. (subsidiary of MPP S.A.)          |                                                               
|Observatory Hotel Ltd.               |                                                                          | Bermuda                                                       
|                                     | Observatory Hotel Pty. Ltd. (subsidiary of Observatory Hotel Ltd.)       |                                                               
|OEH Oxford Ltd.                      |                                                                          | Bermuda                                                       
|                                     | Le Manoir Ltd. (subsidiary of OEH Oxford Ltd.)                           |                                                               
|                                     |                                                                          | Le Manoir Holdings Ltd. (subsidiary of Le Manoir Ltd.)        
|                                     |                                                                          | Blanc Restaurants Ltd. (subsidiary of Le Manoir Holdings Ltd.)
|OEH Peru Ltd.                        |                                                                          | Bermuda                                                       
|OEH Spain Ltd.                       |                                                                          | Bermuda                                                       
|                                     | Nomis Mallorcan Investments S.A. (subsidiary of OEH Spain Ltd.)          |                                                               
|Orient-Express Holdings 1 Ltd.       |                                                                          | Bermuda                                                       
|                                     |                                                                          |                                                               

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|Orient-Express Hotels Inc.                  |                                                                     | Delaware                                                                     
|------------------------------------------- | ------------------------------------------------------------------- | -----------------------------------------------------------------------------
|                                            | Subsidiaries of Orient-Express Hotels Inc.                          |                                                                              
|                                            | '21' Club Properties Inc.                                           |                                                                              
|                                            |                                                                     | '21' Club Inc. (subsidiary of '21' Club Properties Inc.)                     
|                                            | Charleston Place Holdings Inc.                                      |                                                                              
|                                            | El Encanto Inc.                                                     |                                                                              
|                                            | Mountbay Holdings Inc.                                              |                                                                              
|                                            |                                                                     | Subsidiaries of Mountbay Holdings Inc.                                       
|                                            |                                                                     | Inn at Perry Cabin Inc.                                                      
|                                            |                                                                     | Keswick Hall Inc.                                                            
|                                            | Orient-Express Louisiana Inc.                                       |                                                                              
|                                            | Orient-Express Services Inc.                                        |                                                                              
|                                            |                                                                     | Subsidiaries of Orient-Express Services Inc.                                 
|                                            |                                                                     | Keswick Golf Club Inc.                                                       
|                                            |                                                                     |                                                                              
|                                            |                                                                     | Luxury Reservation Services Inc.                                             
|                                            | Venice Simplon-Orient-Express Inc.                                  |                                                                              
|                                            |                                                                     | Orient-Express Travel Inc. (subsidiary of Venice Simplon-Orient-Express Inc.)
|                                            | Windsor Court Hotel Inc.                                            |                                                                              
|Orient-Express Luxembourg Finance S.a.r.l.  |                                                                     | Luxembourg                                                                   
|Orient-Express Luxembourg Holdings S.a.r.l. |                                                                     | Luxembourg                                                                   
|                                            | Subsidiaries of Orient-Express Luxembourg Holdings S.a.r.l.         |                                                                              
|                                            | Collection Venice Simplon-Orient-Express Ltd.                       |                                                                              
|                                            | Venice Simplon-Orient-Express Ltd.                                  |                                                                              
|                                            |                                                                     | Subsidiaries of Venice Simplon-Orient-Express Ltd.                           
|                                            |                                                                     | Northern Belle Ltd.                                                          
|                                            |                                                                     | Venice Simplon-Orient-Express Deutschland G.m.b.H.                           
|                                            |                                                                     | Venice Simplon-Orient-Express Voyages S.A.                                   
|                                            | Orient-Express Hotels Italia S.r.l.                                 |                                                                              
|                                            |                                                                     | Subsidiaries of Orient-Express Hotels Italia S.r.l.                          
|                                            |                                                                     | Hotel Cipriani S.r.l.                                                        
|                                            |                                                                     |                                                                              
|                                            |                                                                     |                                                                              
|                                            |                                                                     |                                                                              
|                                            |                                                                     |                                                                              
|                                            |                                                                     | Hotel Splendido S.r.l.                                                       
|                                            |                                                                     |                                                                              
|                                            |                                                                     | Villa San Michele S.r.l.                                                     
|                                            |                                                                     |                                                                              
|                                            |                                                                     | Orient-Express Hungary Kft                                                   
|Orient-Express Hotels U.K. Ltd.             |                                                                     | U.K.                                                                         
|                                            | Subsidiaries of Orient-Express Hotels U.K. Ltd.                     |                                                                              
|                                            | Horatio Properties Ltd.                                             |                                                                              
|                                            | Orient-Express Services Ltd.                                        |                                                                              
|Orient-Express Spanish Holdings S.L.        |                                                                     | Spain                                                                        
|Reids Hoteis Lda.                           |                                                                     | Portugal                                                                     
|                                            | Island Hotel (Madeira) Ltd. (subsidiary of Reids Hoteis Lda)        |                                                                              
|                                            | Game Viewers (Pty) Ltd. (subsidiary of Island Hotel (Madeira) Ltd.) |                                                                              
|                                            | Game Trackers (Pty) Ltd. (subsidiary of Game Viewers (Pty) Ltd.)    |                                                                              
|                                            |                                                                     |                                                                              

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|Sea Containers Peru Rail Ltd.       |                                                                             | Bermuda
|----------------------------------- | --------------------------------------------------------------------------- | -------
|Viewgrove Holdings Ltd.             |                                                                             | Cyprus 
|                                    | LLC Esanna Holdings (subsidiary of Viewgrove Holdings Ltd.)                 |        
|                                    | LLC Europe Hotel (subsidiary of LLC Esanna Holdings)                        |        
|Windsor New Orleans Properties Ltd. |                                                                             | Bermuda
|                                    | Windsor Great Park Inc. (subsidiary of Windsor New Orleans Properties Ltd.) |        
|                                    | Windsor Court Hotel L.P. (subsidiary of Windsor Great Park Inc.)            |        

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