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EXHIBIT 31.1

CERTIFICATION PURSUANT TO RULE 13a-14(a) AND 15d-14(a),
AS ADOPTED PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF
2002

I, Michael M. Lee, certify that:

|1. | I have reviewed this Annual Report on Form 10-K of AlphaRx, Inc.;                                                                                                                                                                                                                                                                                           
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|2. | Based on my knowledge, this report does not contain any
      untrue statement of a material fact or omit to state a material fact
      necessary to make the statements made, in light of the circumstances under
      which such statements were made, not misleading with respect to the period
      covered by this report;                          
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|3. | Based on my knowledge, the financial statements, and
      other financial information included in this report, fairly present in all
      material respects the financial condition, results of operations and cash
      flows of the registrant as of, and for, the periods presented in this
      report;                                             
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|4. | The registrants other certifying officer and I are
      responsible for establishing and maintaining disclosure controls and
      procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and
      internal control over financial reporting (as defined in Exchange Act
      Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

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| | a. | Designed such disclosure controls and procedures, or
      caused such disclosure controls and procedures to be designed under our
      supervision, to ensure that material information relating to the
      registrant, including its consolidated subsidiary, is made known to us by
      others within that entity, particularly during the period in which this
      report is being prepared;              
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| | b. | Designed such internal control over financial reporting,
      or caused such internal control over financial reporting to be designed
      under our supervision, to provide reasonable assurance regarding the
      reliability of financial reporting and the preparation of financial
      statements for external purposes in accordance with generally accepted
      accounting principles;                
| |    |                                                                                                                                                                                                                                                                                                                                                                                                                      
| | c. | Evaluated the effectiveness of the registrants
      disclosure controls and procedures and presented in this report our
      conclusions about the effectiveness of the disclosure controls and
      procedures, as of the end of the period covered by this report based on
      such evaluation; and                                                                                                          
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| | d. | Disclosed in this report any change in the registrants
      internal control over financial reporting that occurred during the
      registrants most recent fiscal quarter (the registrants fourth fiscal
      quarter in the case of an annual report) that has materially affected, or
      is reasonably likely to materially affect, the registrants internal
      control over financial reporting; and

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|5. | The registrants other certifying officer and I have
      disclosed, based on our most recent evaluation of internal control over
      financial reporting, to the registrants auditors and the audit committee
      of the registrants board of directors (or persons performing the
      equivalent functions):

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| | a. | All significant deficiencies and material weaknesses in
      the design or operation of internal control over financial reporting which
      are reasonably likely to adversely affect the registrants ability to
      record, process, summarize and report financial information; and
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| | b. | Any fraud, whether or not material, that involves
      management or other employees who have a significant role in the
      registrants internal control over financial reporting.                                                                                                     

Date: December 31, 2010

/s/ Michael M. Lee Michael M. LeePresident and Chief
Executive Officer

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