**Exhibit 10.2**

 

**Final VersionPATENT TRANSFER AGREEMENT**

 

THIS AGREEMENT is made as of May 11,2005 by and between Schering Aktiengesellschaft, a German corporation havingits principal place of business at Müllerstraße 178, 13353 Berlin, Germany(hereinafter referred to as “Schering”) and Acusphere, Inc., a Delawarecorporation having its place of business at 500 Arsenal Street, Watertown, MA02472, USA (hereinafter referred to as “Acusphere”). Schering and Acusphere aresometimes referred to herein individually as a “Party” and collectively as the “Parties”.

 

WITNESSETH:

 

WHEREAS, on December 16,2004 Schering and Acusphere have entered into a Confidentiality Agreement withrespect to information regarding ultrasound contrast agents and related patentsand patent applications;

 

WHEREAS, Acusphereindicated its interest in acquiring the Ultrasound Patents (hereinafterdefined);

 

WHEREAS, Schering andAcusphere have previously entered into a non-binding term sheet (the “TermSheet”) regarding the acquisition of the Ultrasound Patents by Acusphere andwish to incorporate the terms and conditions of such Term Sheet in more detailin a binding agreement.

 

NOW, THEREFORE, theParties hereby agree as follows:

 

# **Article I - Definitions**

 

**“Affiliate”**shall mean, with respect to a Party, any person, corporation, firm, jointventure, or other entity which, directly or indirectly, by itself or throughone or more intermediaries, controls, is controlled by, or is under commoncontrol with such Party.  As used in thisdefinition, the term “control” shall mean the possession of the power to director cause the direction of the management and policies of an entity, whetherthrough the ownership of at least 50 % of the outstanding voting securities orby contract or otherwise.

 

**“Business Day”**shall mean a day which is not a Saturday, a Sunday or other day on which banksare required or authorized by law to be closed in the United States, or inBerlin, Germany.

 

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“**ConfidentialInformation**” shall have the meaning set forth in Section 4.1.

 

**“Effective Date”**shall mean the date first written above.

 

“**Harmonic Imaging Patents**” shall mean allworld-wide pending patent applications and all patents in the field of harmonicimaging as listed in **Appendix C,**including any continuation, continuation-in-part, divisional, provisional orany substitute application, any patent issued with respect to any such patentapplications, any reissue, reexamination, renewal or extension (including anysupplemental patent certificate or certificate of protection) of any suchpatent, and all foreign counterparts existing at the Effective Date which arethe subject matter of the claims of any of the foregoing.

 

**“Losses”** shallhave the meaning set forth in Section 6.1.

 

**“Third Party”**shall mean any entity other than Acusphere or Schering or their respectiveAffiliates.

 

**“Third Party Rights”** shall mean the contracts and agreements relating to the UltrasoundPatents or Ultrasound Trademarks as listed in **Appendix B**.

 

**“Ultrasound Patents”**shall mean all world-wide pending patent applications and all patents in theultrasound field, but not including the Harmonic Imaging Patents, as listed in **Appendix A,** including any continuation,continuation-in-part, divisional, provisional or any substitute application,any patent issued with respect to any such patent applications, any reissue,reexamination, renewal or extension (including any supplemental patentcertificate or certificate of protection) of any such patent, and all foreigncounterparts, and all inventions existing at the Effective Date which are thesubject matter of the claims of any of the foregoing.

 

**“Ultrasound Trademarks”** shall mean the trademarks EchovistÒ and LevovistÒ.

 

# **Article II - Transfer ofUltrasound Patents; License Grant**

 

2.1                                 Asof the Effective Date, Schering hereby sells, assigns and transfers toAcusphere all right, title and interest in and to the Ultrasound Patents,including, but not limited to, all claims for damages already incurred, and theright to sue for past infringement. Acusphere accepts such transfer andassignment. The Ultrasound Trademarks are not part of the transfer. NeitherSchering nor any of its Affiliates owns any trademarks 

 

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relating to ultrasoundcontrast agents other than the Ultrasound Trademarks.   For the avoidance of doubt, Schering makesno sale, assignment and/or transfer of any right, title and interest in or tothe Third Party Rights.  Acusphereaccepts no responsibility or liability under or arising out of any Third PartyRights; provided that, Acusphere acknowledges and agrees that the non-exclusivelicenses previously granted by Schering in the Third Party Rights to certain ofthe Ultrasound Patents shall hereafter continue in effect in accordance withthe terms and conditions of such Third Party Rights.

 

2.2                                 Asof the Effective Date and subject to the terms and conditions contained herein,Acusphere hereby grants to Schering and its Affiliates a non-exclusive,royalty-free, worldwide license under the Ultrasound Patent familycorresponding to EP 0 365 467 B1 (Schering No. 50111)  (the “Licensed Patents”) with the right tosublicense, to use, make or have made, promote, sell and have sold itsultrasound product LevovistÒ;provided that each sublicensee is bound by a written agreement which containsterms and conditions at least as protective of the Licensed Patents as thosecontained herein.  Except for the limitedlicenses expressly granted in this Section 2.2, Acusphere retains allright, title and interest in and to the Licensed Patents.

 

2.2.1    Scheringagrees to promptly notify Acusphere in writing of any actual or threatenedinfringement by a third party of any Licensed Patents or of any claim ofinvalidity or unenforceability of the Licensed Patents.  Acusphere shall have the right, but not theobligation, to prosecute or defend such claims, as applicable.  Schering shall, if requested by Acusphere,provide reasonable assistance to Acusphere, at Acusphere’s expense, inconnection with the prosecution or defense of such claims.

 

2.3                                 Scheringshall be responsible for the execution, delivery and filing of  any and all documents or instrumentsnecessary to vest full title to the Ultrasound Patents in Acusphere.Accordingly, Schering shall, on the Effective Date (or as promptly thereafteras is practicable), provide all declarations and sign, deliver and file alldocuments (or procure that such documents are signed, delivered and filed) thatare necessary for the assignment and transfer of the Ultrasound Patents and/or theirre-registration in the name of Acusphere or an Acusphere Affiliate. Acusphereacknowledges that in order to fulfill its obligations hereunder Schering needsprompt information from Acusphere on the name of the Acusphere Affiliate, inwhich the full title to the Ultrasound Patents shall be vested, if not directlyin Acusphere. In addition, Schering needs to promptly know  the patent counsel of Acusphere who shall beresponsible for the Ultrasound Patents thereafter in the respective countries.Any 

 

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costs associated withthe assignment and transfer of the Ultrasound Patents shall be borne bySchering.

 

2.4                                 Scheringirrevocably covenants to Acusphere that it will not and will ensure that noneof the Schering Affiliates initiate, assist any third party, or otherwiseparticipate in, except where such participation is required pursuant to ajudicial or regulatory order or subpeona, in any claim, proceeding, suit orother similar action to invalidate or otherwise challenge the validity orenforceability of any of the Ultrasound Patents.

 

2.5                                 Scheringshall have paid any annuity, renewal, or administrative fee related to theUltrasound Patents that are due on or before the Effective Date.  As of the Effective Date, Acusphere shall beresponsible for any annuity, renewal or administration fee related to each ofthe Ultrasound Patents; provided, however, (a) in order to permitAcusphere or an Acusphere Affiliate adequate time to assume full administrativeresponsibility for the payment of any annuity, renewal or administrative feesdue for the Ultrasound Patents after the Effective Date, Schering agrees toarrange to pay any such annuity, renewal or administration fee due on theUltrasound Patents within ninety (90) days of the Effective Date (or until suchtime as Acusphere or an Acusphere Affiliate advises Schering, in writing, thatit no longer requires the annuity, renewal or administration fees so due),Acusphere or an Acusphere Affiliate to reimburse Schering for any such fees,and (b) Acusphere shall have no obligation to prosecute or maintain anyUltrasound Patent that it determines, in its sole discretion, to abandon orlapse; provided that Acusphere shall give Schering notice of its intention toabandon any of the Licensed Patents and Schering shall have the right, but notthe obligation, to assume responsibility for the payment of maintenancefees.  Fees already paid by Scheringprior to the Effective Date shall neither totally nor partially be charged backto Acusphere in any way.

 

2.6                                 Scheringshall, on the Effective Date, deliver to Acusphere all copies in its or itscounsel’s possession of files relating to the prosecution and defense of all ofthe Ultrasound Patents, including, without limitation, the entire “file wrapper”(prosecution history) of all issued and pending Ultrasound Patents, includingofficial correspondence (office actions, amendments, etc.) to and from, andnotes of telephone conversations with, any U.S. and foreign governmental orregulatory authority regarding all of the Ultrasound Patents.  After the Effective Date, Schering is willingto assist Acusphere, to the extent that Schering’s internal resources andcapabilities allow, in the filing and prosecution of any patent applications includedin the Ultrasound Patents and in the defense of any of the Ultrasound Patentsbefore the U.S. Patent and Trademark Office and equivalent foreign governmental

 

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authorities.  Acusphere shall reimburse Schering for thereasonable cost of any such cooperation.

 

2.7                                 Schering hereby grants Acusphere and eachAcusphere Affiliate an irrevocable (except as otherwise set forth in Section 7.3),non-exclusive, royalty-free, fully paid up, non-sublicenseable, worldwide,perpetual  right and license to use theHarmonic Imaging Patents solely in connection with exercising its rights in andto any and all of the Ultrasound Patents or in connection with the manufacture, use,importation, or sale of ultrasoundcontrast agents owned or controlled by Acusphere, including without limitation, the right andlicense to develop, have developed, manufacture, have manufactured, market,promote, sell, have sold, offer for sale, have offered for sale, import, haveimported, rent, provide and/or lease products or services which practice orembody, or are configured for use in practicing, the Harmonic Imaging Patentsand the right to practice any method covered by the Harmonic Imaging Patents.

 

### **Article III - Payments;Payment Terms**

 

3.1                                Inconsideration of the assignment and transfer of the Ultrasound Patents,Acusphere shall pay to Schering an overall amount of $7,000,000 (seven millionUSD) to be paid in the following installments:

 

•                  $ 1,000,000.00 (one million USD) within 15 BusinessDays of the Effective Date of this Agreement;

•                  $ 3,000,000.00 (three million USD) within 15Business Days of the first anniversary of the Effective Date of this Agreement;

•                  $ 3,000,000.00 (three million USD) within 15Business Days of the second anniversary of the Effective Date of thisAgreement.

 

Allpayments are due as listed above without invoice and shall be made to a bankaccount to be notified by Schering in due time. For any delayed paymentSchering has the right to charge computed interest to Acusphere at PrimeRate as quoted on internet page ‘http://www.bankofamerica.com/facts/index.cfm?Menu_Sel=primerate’”plusa premium of 3% p.a. computed onthe basis of act/360 year, such interest to be due and payable upon tender ofthe payment.

 

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**Article IV –Confidentiality; Public Announcements**

 

4.1                                 Except to the extent expressly authorized bythis Agreement or otherwise agreed in writing, the Parties agree that thereceiving Party shall keep confidential and shall not publish or otherwisedisclose or use for any purpose other than as provided for in this Agreementany Confidential Information of the other Party.  As used herein, “Confidential Information”means any information and materials other than the Ultrasound Patents orHarmonic Imaging Patents furnished to a Party by the other Party pursuant tothis Agreement that (a) the disclosing Party has marked as confidential orproprietary, or (b) the disclosing Party identifies as confidential at thetime of oral disclosure with written confirmation within 15 days of disclosureto the receiving Party; provided, that the provisions of this Agreementwill be deemed Confidential Information of both Parties; provided, furtherhowever, that reports and/or information related to or regarding thedisclosing Party’s business plans, business methodologies, strategies,technology, specifications, development plans, customers, prospectivecustomers, billing records, and products or services**willbe deemed Confidential Information of the disclosing Party even if not somarked or identified, except to the extent that it can be established by thereceiving Party that such Confidential Information:

 

(a)                                  was already known to the receiving Party, otherthan under an obligation of confidentiality, at the time of disclosure by theother Party, as evidenced by written records maintained by the receiving Partyin the ordinary course of business; or

 

(b)                                 was generally available to the public orotherwise part of the public domain at the time of its disclosure to thereceiving Party; or

 

(c)                                  became generally available to the public orotherwise part of the public domain after its disclosure and other than throughany act or omission of the receiving Party in breach of this Agreement; or

 

(d)                                 was disclosed to the receiving Party, otherthan under an obligation of confidentiality, by a Third Party who had noobligation to the disclosing Party not to disclose such information to others.

 

4.2                                 Each Party may disclose Confidential Informationhereunder to the extent such disclosure is reasonably necessary to comply withapplicable governmental laws, rules and regulations, including, withoutlimitation, those of the U.S. Food and Drug Administration (“FDA”) andSecurities and Exchange Commission.  If aParty is required by law or regulation to make any such disclosure of the otherParty’s Confidential Information it will give reasonable advance notice to theother Party of 

 

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such disclosure requirement and shall permit the otherParty to intervene therein to protect its interests in its ConfidentialInformation, and provide full cooperation and assistance to other Party inseeking to obtain such protection; provided, however, that none of the rightsand obligations set forth in this sentence shall apply to any such disclosureby Acusphere in a Form 8-K or Form 10-Q which is filed with theSecurities and Exchange Commission within 45 days of the Effective Date.

 

4.3                                 Notwithstanding any of the foregoing to thecontrary, Acusphere may prepare and issue a press release announcing anddescribing this Agreement and the transaction contemplated hereby.  At least 5 (five) Business Days prior toreleasing such press release, Acusphere shall give Schering the opportunity toreview and comment thereon. Acusphere shall refer to Schering in such releaseas “Schering AG, Germany”.

 

4.4                                 Except as set forth in Section 4.3,neither Party shall use the name of the other Party or any Affiliate of theother Party in relation to this Agreement or the transactions described hereinin any public announcement, press release or other public document without thewritten consent of such other Party, which consent shall not be unreasonablywithheld, conditioned or delayed; provided, however, that either Party may usethe name of the other Party in any document filed with any regulatory agency orauthority to comply with legal or regulatory requirements, including the FDAand the Securities and Exchange Commission, in which cases Acusphere shallrefer to Schering as “Schering AG, Germany”. Notwithstanding the foregoing, Schering agrees not to disclose the termsof this Agreement to its sublicensees within 90 days after the Effective Date.

 

4.5                                This Article IV shall survive terminationor expiration of this Agreement.

 

##### **Article V - Representations and Warranties;Limitation**

 

5.1                                Each of the Parties represents and warrants tothe other Party that (a) it has full right, power and authority to executeand deliver this Agreement and to consummate the transactions contemplatedhereby, (b) this Agreement is a legal and valid obligation binding uponsuch Party and enforceable in accordance with its terms, and (c) theexecution, delivery and performance of the Agreement by such Party does notconflict with any agreement, instrument or understanding, oral or written, towhich it is a Party or by which it is bound, nor to such Party’s knowledge,violate any law or regulation of any court, governmental body or administrativeor other agency having jurisdiction over it.

 

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5.2                                Schering hereby represents and warrants toAcusphere that

 

(a)                        Schering is the rightful and exclusive owner ofall right, title and interest in and to the Ultrasound Patents;

 

(b)                       the Ultrasound Patents are free and clear ofany liens, license rights, security interests, encumbrances or rights torepurchase, other than those listed in **Appendix B**;

 

(c)                        each of the Ultrasound Patents is properlyfiled or issued, as applicable, currently in compliance with formal legalrequirements (including, without limitation, payment of filing, examination andgovernmental taxes and maintenance fees) and enforceable and, to the knowledgeof Schering or any of its Affiliates, valid.

 

(d)                       there are no pending, or, to the knowledge ofSchering or any of its Affiliates, threatened claims against Schering or any ofits Affiliates claiming that the making, using, selling, offering for sale orimporting of products or services which are covered by the subject matter ofthe claims of the Ultrasound Patents infringe on or violate any patent or otherintellectual property right of a person or entity or that any of the UltrasoundPatents is invalid or unenforceable and Schering is not aware of any facts orcircumstances that would form the basis for a determination that any of suchUltrasound Patents are invalid or unenforceable.

 

(e)                        to the knowledge of Schering or any of itsAffiliates, the making, using, selling, offering for sale or importing of productsor services which are covered by the subject matter of the claims of theUltrasound Patents does not infringe on or violate (or in the past did notinfringe on or violate) any patent or other intellectual property right of aperson or entity.

 

(f)                          to the knowledge of Schering or any of itsAffiliates, there is no, nor has there been any, infringement or violation oralleged infringement or violation by any person or entity of any of Schering’srights in or to the Ultrasound Patents.

 

(g)                       All licenses or other agreements under whichSchering has granted rights to others in the Ultrasound Patents are listed in **Appendix B** attached hereto. All such licenses or other agreements are in full force and effect, and,to the 

 

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knowledge of Schering there is no material default byany Party thereto.  True and completecopies of all such licenses or other agreements, and any amendments thereto,have been provided to Acusphere with certain limited redactions thereto, andSchering has all requisite power and authority to grant the rights purported tobe conferred thereby.

 

(h)                       **AppendixA**comprises a complete and accurate listing of all patents and patentapplications owned or controlled by Schering or any Affiliate of Schering inthe ultrasound field; and  **Appendix C** comprises a complete and accurate listing of allHarmonic Imaging Patents owned or controlled by Schering or any Affiliate ofSchering.

 

5.3                                EXCEPT AS SET FORTH ABOVE IN SECTION 5.2,EACH PARTY MAKES NO AND DISCLAIMS ANY OTHER WARRANTY OR REPRESENTATION, EXPRESSOR IMPLIED, CONCERNING THE ULTRASOUND PATENTS, INCLUDING ANY WARRANTY OFMERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE,

 

##### **Article VI - Indemnification**

 

6.1                                Without prejudice to any other right or remedyavailable to either Party arising out of the breach by the other of any of therepresentations and warranties set out in Sections 5.1 and 5.2 above, eachParty hereby agrees to indemnify, defend and hold the other Party and itsAffiliates, directors, officers, and employees harmless from and against anyand all suits, claims, actions, demands, liabilities, expenses and/or losses,including reasonable legal expenses and attorneys’ fees (collectively, “Losses”and each a “Loss”), resulting directly or indirectly from (i) the materialbreach of any obligation under this Agreement, or (ii) the material breachof any representation or warranty made by such Party hereunder; providedhowever that neither party shall indemnify the other party for loss of profit.

 

6.2                                Each indemnified Party agrees to give theindemnifying Party prompt written notice of any Loss or discovery of fact uponwhich such indemnified Party intends to base a request for indemnificationunder Section 6.1.  Each Party shallfurnish promptly to the other copies of all papers and official documentsreceived in respect of any Loss. The indemnifying Party shall have the soleright to defend, settle or otherwise dispose of such Loss, on such terms as theindemnifying Party, in its sole discretion, shall deem appropriate. Theindemnifying Party shall obtain the written consent of the indemnified Party,which shall not be unreasonably withheld or delayed, prior to 

 

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ceasing to defend, settling or otherwise disposing ofany Loss if as a result thereof the indemnified Party would become subject toinjunctive or other equitable relief or any remedy other than the payment ofmoney, which payment would be the responsibility of the indemnifying Party. Theindemnifying Party shall not be liable for any settlement or other dispositionof a Loss by the indemnified Party which is reached without the written consentof the indemnifying Party. The reasonable costs and expenses, includingreasonable fees and disbursements of counsel incurred by any indemnified Partyin connection with any Loss, shall be reimbursed on a quarterly basis by theindemnifying Party, without prejudice to the indemnifying Party’s right tocontest the indemnified Party’s right to indemnification and subject to refundin the event the indemnifying Party is ultimately held not to be obligated toindemnify the indemnified Party.

 

6.3                                This Article VI shall survive thetermination or expiration of this Agreement.

 

##### ** ****Article VII - Term and Termination**

 

7.1                                This Agreement shall come into force on theEffective Date and shall continue in effect until the last Ultrasound Patentlicensed back to Schering under Section 2.2 has expired.

 

7.2                                In case that Schering or any of its Affiliatesor sublicensees of Schering or any of Schering’s Affiliates attempts tochallenge the validity or enforceability of the Licensed Patents, Acusphere hasthe right to immediately terminate the license granted in Section 2.2above upon written notice.

 

7.3                                In the event thatAcusphere acquires (whether through a purchase of assets or stock, merger orotherwise) a Third Party  which,immediately prior to the closing of such acquisition, is a party to aneffective agreement under which Schering has granted such Third Party a royaltybearing license under any of the Harmonic Imaging Patents (any such agreement,a “Harmonic Imaging Patent License”), Acusphere shall promptly notify Scheringof such acquisition.  Thereafter, uponSchering’s written request, the parties shall amend this Agreement to clarifythat the Harmonic Imaging Patent License royalty obligations with respect tothe Harmonic Imaging Patents covered therein supercede the royalty free licensegranted in Section 2.7 above and confirm that Acusphere and/or an AcusphereAffiliate, as applicable, shall pay all royalties set forth in and subject tothe terms and conditions of the Harmonic Imaging Patent License with respect tothose Harmonic Imaging Patents covered therein.

 

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7.4                                The rights and obligations set forth in thisAgreement shall extend beyond the expiration of this Agreement only to theextent expressly provided for herein, or to the extent that the survival ofsuch rights or obligations are necessary to permit their complete fulfillmentor discharge

 

##### **Article VIII - Miscellaneous**

 

8.1                                Amendments. No subsequent amendment or addition to this Agreement shall be bindingupon the Parties unless executed in writing and signed by the respectiveauthorized representatives of the Parties.

 

8.2                                Headings.  The section and paragraphheadings contained herein are for the purposes of convenience only and are notintended to define or limit the contents of said sections or paragraphs.

 

8.3                                Further Actions.  EachParty agrees to execute, acknowledge and deliver such further instruments, andto do all such other acts, as may be necessary or appropriate in order to carryout the purposes and intent of the Agreement.

 

8.4                                Severability. Each Party hereby agrees that it does not intend, by its executionhereof, to violate any public policies, statutory or common laws, rules,regulations, treaties or decisions of any government agency or executive bodythereof of any country or community or association of countries.  Should one or more provisions of thisAgreement be or become invalid, the Parties hereto shall substitute, by mutualconsent, valid provisions for such invalid provisions, which valid provisionsin their economic and other effects are sufficiently similar to the invalid provisionsthat it can be reasonably assumed that the Parties would have entered into thisAgreement with such valid provisions.  Incase such valid provisions cannot be agreed upon, the invalidity of one orseveral provisions of this Agreement shall not affect the validity of thisAgreement as a whole, unless the invalid provisions are of such essentialimportance to this Agreement that it is to be reasonably assumed that theParties would not have entered into this Agreement without the invalidprovision.

 

8.5                                Prior Agreements.  ThisAgreement constitutes the full and entire understanding and agreement among theParties hereto with respect to the subject matters hereof, and any and allother written or oral agreements existing prior to or contemporaneously herewith,including but not limited to, the Term Sheet between the Parties, are herebyexpressly superseded by the provisions of this Agreement. The ConfidentialityAgreement dated December 16, 2004 shall continue to apply.

 

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8.6                                Notices.    All notices, requests, demands and othercommunications hereunder shall be in writing and shall be deemed to have beenduly given when delivered personally or when mailed, by certified or registeredmail, prepaid, to the Parties or their assignees at the address set forth above(or at such other address as shall be given in writing by a Party).

 

8.7                                Governing Law and Dispute Resolution.

 

ThisAgreement shall be governed by and construed in accordance with the laws ofGermany. All disputes arising in connection with this Agreement or its validitywhich cannot be resolved amicably by the Parties shall be finally settledaccording to the rules of the German Institution of Arbitration e.V.(Deutsches Institut für Schiedsgerichtsbarkeit e.V.) without recourse to theordinary courts of law except for interim proceedings (*einstweiligerRechtschutz*). The exclusive place of arbitration shall be Frankfurtam Main, Germany. The arbitral tribunal shall consist of three arbitrators, onearbitrator to be appointed by each Party and the third to be appointed by theArbitration Institution. The language of the arbitral proceedings shall beEnglish.

 

INWITNESS WHEREOF, Schering and Acusphere have caused this Agreement to beexecuted as of the Effective Date by their respective duly authorizedrepresentatives.

 
| Acusphere, Inc.     | Schering  Aktiengesellschaft                |
|--------------------------|---------------------------------------------|
|                     |                                        |
| /s/  Sherri C. Oberg     |                                        | /s/ H.M.  Rook |   |
| Name: Sherri C. Oberg    | Name: H.M. Rook                             |
| Title: President and CEO | Title: Head of GBU Diagnostic Imaging       |
|                     |                                        |
|                     |                                        |
|                     | /s/ Dr. T.  Fritzsch                   |   |
|                     | Name: Dr. T.  Fritzsch                 |
|                     | Title:                                      | Business  Development Diagnostic |
|                     | Imaging,  Licensing & Cooperations |
|                          |                                             |  |  |  |

 

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**Appendix A - Ultrasound Patents**

 

**PatentFamily # 03228A**

 
| **Ctry** | ** ** | **Type** | ** ** | **Filing**  | ** ** | **Filing   Number** | ** ** | **Publication** | ** ** | **Grant**   | ** ** | **Grant  number** | ** ** | **Proc** | ** ** | **Date**    | ** ** | **Nature** | ** ** | **Exp**     | ** ** |
|----------|------------|----------|------------|-------------|------------|---------------------|------------|-----------------|------------|-------------|------------|-------------------|------------|----------|------------|-------------|------------|------------|------------|-------------|------------|
| DE       |       | NP1      |       | 05/Feb/1988 |       | P 3803972.9         |       | 10/Aug/1989     |       | 04/Jul/1989 |       | 3803972           |       | GRT      |       | 04/Jul/1989 |       | 3803972    |       | 05/Feb/2008 |       |
| DK       |       | PCT1     |       | 01/Feb/1989 |       | 1864/90             |       |            |       |        |       |              |       | NATF     |       | 03/Aug/1990 |       | 1864/90    |       | 01/Feb/2009 |       |
| US       |       | CNT2     |       | 11/Jun/1990 |       | 07/536377           |       |            |       |        |       |              |       | FLG      |       | 11/Jun/1990 |       | 07/536377  |       |        |       |
| US       |       | CNT3     |       | 07/Jun/1993 |       | 08/072748           |       |            |       | 20/Jun/1995 |       | 5425366           |       | GRT      |       | 20/Jun/1995 |       | 5425366    |       | 20/Jun/2012 |       |
| US       |       | CNT4     |       | 13/Feb/1995 |       | 08/387612           |       |            |       |        |       |              |       | FLG      |       | 13/Feb/1995 |       | 08/387612  |       |        |       |
| US       |       | CNT5     |       | 07/Jun/1995 |       | 08/477642           |       |            |       | 06/Jun/2000 |       | 6071496           |       | GRT      |       | 06/Jun/2000 |       | 6071496    |       | 06/Jun/2017 |       |
| US       |       | CNT6     |       | 07/Jun/1995 |       | 08/474468           |       |            |       | 23/Jan/2001 |       | 6177062 B1        |       | GRT      |       | 23/Jan/2001 |       | 6177062 B1 |       | 06/Jun/2017 |       |
| US       |       | CNT7     |       | 29/Nov/1995 |       | 08/563926           |       |            |       |        |       |              |       | FLG      |       | 29/Nov/1995 |       | 08/563926  |       | 03/Feb/2009 |       |
| US       |       | CNT8     |       | 24/Feb/2000 |       | 09/512473           |       |            |       |        |       |              |       | FLG      |       | 24/Feb/2000 |       | 09/512473  |       | 03/Feb/2009 |       |

 

A-1

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**PatentFamily # 50111A**

 
| **Ctry** | ** ** | **Type** | ** ** | **Filing**  | ** ** | **Filing Number** | ** ** | **Publication** | ** ** | **Grant**   | ** ** | **Grant  number** | ** ** | **Proc** | ** ** | **Date**    | ** ** | **Nature**      | ** ** | **Exp**     | ** ** |
|----------|------------|----------|------------|-------------|------------|-------------------|------------|-----------------|------------|-------------|------------|-------------------|------------|----------|------------|-------------|------------|-----------------|------------|-------------|------------|
| DE       |       | EPA1     |       | 06/Apr/1989 |       | 89730095.0        |       | 25/Apr/1990     |       | 18/Aug/1993 |       | P 58905318.3-08   |       | GRT      |       | 18/Aug/1993 |       | P 58905318.3-08 |       | 06/Apr/2009 |       |
| DE       |       | SPC1     |       | 07/Jun/1996 |       | 19675015.6        |       |            |       | 13/Dec/1995 |       | 32851.00.00       |       | GRT      |       | 13/Dec/1995 |       | 32851.00.00     |       | 21/Jun/2010 |       |
| ES       |       | EPA1     |       | 06/Apr/1989 |       | 89730095.0        |       | 25/Apr/1990     |       | 18/Aug/1993 |       | 0365467           |       | GRT      |       | 18/Aug/1993 |       | 0365467         |       | 06/Apr/2009 |       |
| ES       |       | SPC1     |       | 29/Jan/1998 |       | C 9800006         |       |            |       | 01/Sep/1999 |       | C 9800006         |       | GRT      |       | 01/Sep/1999 |       | C 9800006       |       | 21/Jun/2010 |       |
| FR       |       | EPA1     |       | 06/Apr/1989 |       | 89730095.0        |       | 25/Apr/1990     |       | 18/Aug/1993 |       | 0365467           |       | GRT      |       | 18/Aug/1993 |       | 0365467         |       | 06/Apr/2009 |       |
| FR       |       | SPC1     |       | 06/Apr/1989 |       | 89730095.0        |       |            |       | 10/Oct/1999 |       | 97 C 0008         |       | GRT      |       | 10/Oct/1999 |       | 97 C 0008       |       | 20/Jun/2010 |       |
| GB       |       | EPA1     |       | 06/Apr/1989 |       | 89730095.0        |       | 25/Apr/1990     |       | 18/Aug/1993 |       | 0365467           |       | GRT      |       | 18/Aug/1993 |       | 0365467         |       | 06/Apr/2009 |       |
| GB       |       | SPC1     |       | 22/Nov/1996 |       | SPC/GB96/055      |       |            |       | 21/Apr/1997 |       | SPC/GB96/055      |       | GRT      |       | 21/Apr/1997 |       | SPC/GB96/055    |       | 20/Jun/2010 |       |
| IT       |       | EPA1     |       | 06/Apr/1989 |       | 89730095.0        |       | 25/Apr/1990     |       | 18/Aug/1993 |       | 0365467           |       | GRT      |       | 18/Aug/1993 |       | 0365467         |       | 06/Apr/2009 |       |
| IT       |       | SPC1     |       | 30/Oct/1996 |       |              |       |            |       |        |       |              |       | FLG      |       | 30/Oct/1996 |       |            |       | 06/Apr/2014 |       |
| JP       |       | NP1      |       | 04/Oct/1989 |       | 258007/89         |       |            |       | 11/Jan/1996 |       | 2005630           |       | GRT      |       | 11/Jan/1996 |       | 2005630         |       | 04/Oct/2009 |       |
| JP       |       | SPC1     |       | 03/Sep/1999 |       | 11-700082         |       |            |       | 22/Feb/2001 |       | 2005630           |       | GRT      |       | 22/Feb/2001 |       | 2005630         |       | 04/Oct/2014 |       |

 

A-2

----

 

**PatentFamily # 50622A**

 
| **Ctry** | ** ** | **Type** | ** ** | **Filing**  | ** ** | **Filling  Number** | ** ** | **Publication** | ** ** | **Grant**   | ** ** | **Grant  number** | ** ** | **Proc** | ** ** | **Date**    | ** ** | **Nature**     | ** ** | **Exp**     | ** ** |
|----------|------------|----------|------------|-------------|------------|---------------------|------------|-----------------|------------|-------------|------------|-------------------|------------|----------|------------|-------------|------------|----------------|------------|-------------|------------|
| AT       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | E 163134          |       | GRT      |       | 11/Feb/1998 |       | E 163134       |       | 05/Jun/2013 |       |
| BE       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| CH       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| DE       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 59308146.3-08     |       | GRT      |       | 11/Feb/1998 |       | 59308146.3-08  |       | 05/Jun/2013 |       |
| DK       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| EP       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| ES       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| FR       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| GB       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| GR       |       | EPT1     |       | 02/Jun/1993 |       | 20040400095         |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 3026498.B2        |       | GRT      |       | 11/Feb/1998 |       | 3026498.B2     |       | 02/Jun/2013 |       |
| IT       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| LU       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| MC       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| NL       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| NO       |       | PCT1     |       | 05/Jun/1993 |       | 19944805            |       |            |       | 08/May/2000 |       | 307646            |       | GRT      |       | 08/May/2000 |       | 307646         |       | 05/Jun/2013 |       |
| PT       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777           |       | GRT      |       | 11/Feb/1998 |       | 0644777        |       | 05/Jun/2013 |       |
| SE       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 93912897-1        |       | GRT      |       | 11/Feb/1998 |       | 93912897-1     |       | 05/Jun/2013 |       |
| US       |       | PCT1     |       | 05/Jun/1993 |       | 08/351372           |       |            |       |        |       |              |       | NATF     |       | 13/Dec/1994 |       | 08/351372      |       |        |       |
| IE       |       | EPT1     |       | 05/Jun/1993 |       | 93912897.1          |       | 29/Mar/1995     |       | 11/Feb/1998 |       | 0644777/E78869    |       | GRT      |       | 11/Feb/1998 |       | 0644777/E78869 |       | 05/Jun/2013 |       |

 

A-3

----

 

**PatentFamily # 50686A**

 
| **Ctry** | ** ** | **Type** | ** ** | **Filing**  | ** ** | **Filing  Number** | ** ** | **Publication** | ** ** | **Grant**   | ** ** | **Grant  number** | ** ** | **Proc** | ** ** | **Date**    | ** ** | **Nature**        | ** ** | **Exp**     | ** ** |
|----------|------------|----------|------------|-------------|------------|--------------------|------------|-----------------|------------|-------------|------------|-------------------|------------|----------|------------|-------------|------------|-------------------|------------|-------------|------------|
| AT       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | E 173937          |       | GRT      |       | 02/Dec/1998 |       | E 173937          |       | 24/Apr/2013 |       |
| BE       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| CA       |       | PCT1     |       | 24/Apr/1993 |       | 2137910            |       |            |       | 03/Jun/2003 |       | 2137910           |       | GRT      |       | 03/Jun/2003 |       | 2137910           |       | 24/Apr/2013 |       |
|     |       |     |       |        |       |               |       |            |       |        |       |              |       |     |       |        |       |              |       |        |       |
| CH       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| DE       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 59309189.2-08     |       | GRT      |       | 02/Dec/1998 |       | 59309189.2-08     |       | 24/Apr/2013 |       |
| DK       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| ES       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| FR       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| GB       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| GR       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 990400590/3029494 |       | GRT      |       | 02/Dec/1998 |       | 990400590/3029494 |       | 24/Apr/2013 |       |
| IE       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| IT       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| LU       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| MC       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| NL       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| NO       |       | PCT1     |       | 24/Apr/1993 |       | 944806             |       |            |       | 25/Sep/2000 |       | 308510            |       | GRT      |       | 25/Sep/2000 |       | 308510            |       | 24/Apr/2013 |       |
| PT       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 0644776           |       | GRT      |       | 02/Dec/1998 |       | 0644776           |       | 24/Apr/2013 |       |
| SE       |       | EPT1     |       | 24/Apr/1993 |       | 93911501.0         |       | 29/Mar/1995     |       | 02/Dec/1998 |       | 93911501-0        |       | GRT      |       | 02/Dec/1998 |       | 93911501-0        |       | 24/Apr/2013 |       |

 

A-4

----

 

**PatentFamily #50716A**

 
| **Ctry** | ** ** | **Type** | ** ** | **Filing**  | ** ** | **Filing Number** | ** ** | **Publication** | ** ** | **Grant**   | ** ** | **Grant  number** | ** ** | **Proc** | ** ** | **Date**    | ** ** | **Nature**        | ** ** | **Exp**     | ** ** |
|----------|------------|----------|------------|-------------|------------|-------------------|------------|-----------------|------------|-------------|------------|-------------------|------------|----------|------------|-------------|------------|-------------------|------------|-------------|------------|
| AT       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | E 165517          |       | GRT      |       | 29/Apr/1998 |       | E 165517          |       | 08/Sep/2013 |       |
| BE       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 0662005           |       | GRT      |       | 29/Apr/1998 |       | 0662005           |       | 08/Sep/2013 |       |
| CA       |       | PCT1     |       | 08/Sep/1993 |       | 2145505           |       |            |       | 17/Feb/2004 |       | CA 2145505        |       | GRT      |       | 17/Feb/2004 |       | CA 2145505        |       | 08/Sep/2013 |       |
| CH       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 0662005           |       | GRT      |       | 29/Apr/1998 |       | 0662005           |       | 08/Sep/2013 |       |
| CN       |       | NP1      |       | 25/Sep/1993 |       | 93118159.3        |       | 20/Jul/1994     |       | 06/Feb/2002 |       | 80509             |       | GRT      |       | 06/Feb/2002 |       | 80509             |       | 25/Sep/2013 |       |
| DE       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 59308479.9-08     |       | GRT      |       | 29/Apr/1998 |       | 59308479.9-08     |       | 08/Sep/2013 |       |
| DE       |       | NP1      |       | 26/Sep/1992 |       | P 4232755.5       |       | 31/Mar/1994     |       |        |       |              |       | PUB      |       | 31/Mar/1994 |       | DE 4232755 A1     |       | 26/Sep/2012 |       |
| DK       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 0662005           |       | GRT      |       | 29/Apr/1998 |       | 0662005           |       | 08/Sep/2013 |       |
| ES       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 0662005           |       | GRT      |       | 29/Apr/1998 |       | 0662005           |       | 08/Sep/2013 |       |
| FI       |       | PCT1     |       | 08/Sep/1993 |       | 951379            |       |            |       |        |       |              |       | NATF     |       | 23/Mar/1995 |       |              |       | 08/Sep/2013 |       |
| FR       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 0662005           |       | GRT      |       | 29/Apr/1998 |       | 0662005           |       | 08/Sep/2013 |       |
| GB       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 0662005           |       | GRT      |       | 29/Apr/1998 |       | 0662005           |       | 08/Sep/2013 |       |
| GR       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 980401268/3027050 |       | GRT      |       | 29/Apr/1998 |       | 980401268/3027050 |       | 08/Sep/2013 |       |
| IE       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       |            |       | 29/Apr/1998 |       | 0662005/E 80081   |       | GRT      |       | 29/Apr/1998 |       | 0662005/E 80081   |       | 08/Sep/2013 |       |
| IT       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 0662005           |       | GRT      |       | 29/Apr/1998 |       | 0662005           |       | 08/Sep/2013 |       |
| LU       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 0662005           |       | GRT      |       | 29/Apr/1998 |       | 0662005           |       | 08/Sep/2013 |       |
| MC       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 0662005           |       | GRT      |       | 29/Apr/1998 |       | 0662005           |       | 08/Sep/2013 |       |
| NL       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 0662005           |       | GRT      |       | 29/Apr/1998 |       | 0662005           |       | 08/Sep/2013 |       |
| NO       |       | PCT1     |       | 08/Sep/1993 |       | 19951138          |       |            |       | 15/May/2000 |       | 307692            |       | GRT      |       | 15/May/2000 |       | 307692            |       | 08/Sep/2013 |       |
| PT       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 0662005           |       | GRT      |       | 29/Apr/1998 |       | 0662005           |       | 08/Sep/2013 |       |
| SE       |       | EPT1     |       | 08/Sep/1993 |       | 93919293.6        |       | 12/Jul/1995     |       | 29/Apr/1998 |       | 93919293.6        |       | GRT      |       | 29/Apr/1998 |       | 93919293.6        |       | 08/Sep/2013 |       |
| US       |       | CWO1     |       | 21/Jul/1997 |       | 08/897319         |       | 07/Mar/2002     |       | 07/May/2002 |       | 6383470 B1        |       | GRT      |       | 07/May/2002 |       | 6383470 B1        |       | 08/Sep/2013 |       |
| US       |       | PCT1     |       | 08/Sep/1993 |       | 08/406882         |       |            |       |        |       |              |       | NATF     |       | 27/Mar/1995 |       | 08/406882         |       |        |       |

 

A-5

----

 

**PatentFamily #50902A**

 
| **Ctry** | ** ** | **Type** | ** ** | **Filing**  | ** ** | **Filing  Number** | ** ** | **Publication** | ** ** | **Grant**   | ** ** | **Grant  number**   | ** ** | **Proc** | ** ** | **Date**    | ** ** | **Nature**          | ** ** | **Exp**     | ** ** |
|----------|------------|----------|------------|-------------|------------|--------------------|------------|-----------------|------------|-------------|------------|---------------------|------------|----------|------------|-------------|------------|---------------------|------------|-------------|------------|
| AT       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| BE       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| CA       |       | PCT1     |       | 25/Aug/1994 |       | 2171303            |       |            |       |        |       |                |       | FLG      |       | 25/Aug/1994 |       | 2171303             |       | 25/Aug/2014 |       |
| CH       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| DE       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 59409568.9-08       |       | GRT      |       | 25/Oct/2000 |       | 59409568.9-08       |       | 25/Aug/2014 |       |
| DK       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| ES       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| FR       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| GB       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| GR       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 20010400035/3035219 |       | GRT      |       | 25/Oct/2000 |       | 20010400035/3035219 |       | 25/Aug/2014 |       |
| IE       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| IT       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| LU       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| MC       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| NL       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| NO       |       | PCT1     |       | 25/Aug/1994 |       | 960973             |       |            |       | 04/Mar/2002 |       | 312007              |       | GRT      |       | 04/Mar/2002 |       | 312007              |       | 25/Aug/2014 |       |
| PT       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 0717617             |       | GRT      |       | 25/Oct/2000 |       | 0717617             |       | 25/Aug/2014 |       |
| SE       |       | EPT1     |       | 25/Aug/1994 |       | 94926878.3         |       | 26/Jun/1996     |       | 25/Oct/2000 |       | 94926878.3          |       | GRT      |       | 25/Oct/2000 |       | 94926878.3          |       | 25/Aug/2014 |       |
| US       |       | DWO1     |       | 13/Dec/1999 |       | 09/459578          |       |            |       | 04/Sep/2001 |       | 6284280 B1          |       | GRT      |       | 04/Sep/2001 |       | 6284280 B1          |       | 25/Aug/2014 |       |
| US       |       | PCT1     |       | 25/Aug/1994 |       | 08/605174          |       |            |       | 30/May/2000 |       | 6068857             |       | GRT      |       | 30/May/2000 |       | 6068857             |       | 30/May/2017 |       |

 

A-6

----

 

**Patentfamily # 51090A**

 
| **Ctry** | ** ** | **Type** | ** ** | **Filing**  | ** ** | **Filing  Number** | ** ** | **Publication** | ** ** | **Grant**   | ** ** | **Grant  number** | ** ** | **Proc** | ** ** | **Date**    | ** ** | **Nature**    | ** ** | **Exp**     | ** ** |
|----------|------------|----------|------------|-------------|------------|--------------------|------------|-----------------|------------|-------------|------------|-------------------|------------|----------|------------|-------------|------------|---------------|------------|-------------|------------|
| AT       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 0744961           |       | GRT      |       | 19/Sep/2001 |       | 0744961       |       | 10/Feb/2015 |       |
| BE       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 0744961           |       | GRT      |       | 19/Sep/2001 |       | 0744961       |       | 10/Feb/2015 |       |
| CH       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 0744961           |       | GRT      |       | 19/Sep/2001 |       | 0744961       |       | 10/Feb/2015 |       |
| DE       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 59509618.2-08     |       | GRT      |       | 19/Sep/2001 |       | 59509618.2-08 |       | 10/Feb/2015 |       |
| DK       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 0744961           |       | GRT      |       | 19/Sep/2001 |       | 0744961       |       | 10/Feb/2015 |       |
| ES       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 0744961           |       | GRT      |       | 19/Sep/2001 |       | 0744961       |       | 10/Feb/2015 |       |
| FR       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 0744961           |       | GRT      |       | 19/Sep/2001 |       | 0744961       |       | 10/Feb/2015 |       |
| GB       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 0744961           |       | GRT      |       | 19/Sep/2001 |       | 0744961       |       | 10/Feb/2015 |       |
| IE       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 0744961           |       | GRT      |       | 19/Sep/2001 |       | 0744961       |       | 10/Feb/2015 |       |
| IT       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 0744961           |       | GRT      |       | 19/Sep/2001 |       | 0744961       |       | 10/Feb/2015 |       |
| JP       |       | PCT1     |       | 10/Feb/1995 |       | 07-522099          |       |            |       |        |       |              |       | FLG      |       | 10/Feb/1995 |       | 07-522099     |       |        |       |
| NL       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 0744961           |       | GRT      |       | 19/Sep/2001 |       | 0744961       |       | 10/Feb/2015 |       |
| NO       |       | PCT1     |       | 10/Feb/1995 |       | 19963501           |       |            |       | 21/May/2002 |       | 312497            |       | GRT      |       | 21/May/2002 |       | 312497        |       | 10/Feb/2015 |       |
| PT       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 0744961           |       | GRT      |       | 19/Sep/2001 |       | 0744961       |       | 10/Feb/2015 |       |
| SE       |       | EPT1     |       | 10/Feb/1995 |       | 95909702.3         |       | 04/Dec/1996     |       | 19/Sep/2001 |       | 95909702.3        |       | GRT      |       | 19/Sep/2001 |       | 95909702.3    |       | 10/Feb/2015 |       |
| US       |       | DWO1     |       | 06/Aug/1998 |       | 09/129953          |       |            |       | 23/Oct/2001 |       | 6306366 B1        |       | GRT      |       | 23/Oct/2001 |       | 6306366 B1    |       | 10/Feb/2015 |       |
| US       |       | PCT1     |       | 10/Feb/1995 |       | 08/700354          |       |            |       |        |       |              |       | NATF     |       | 21/Oct/1996 |       | 08/700354     |       |        |       |

 

A-7

----

 

**PatentFamily #51639A**

 
| **Ctry** | ** ** | **Type** | ** ** | **Filing**  | ** ** | **Filing Number**  | ** ** | **Publication** | ** ** | **Grant**   | ** ** | **Grant  number** | ** ** | **Proc** | ** ** | **Date**    | ** ** | **Nature**    | ** ** | **Exp**     | ** ** |
|----------|------------|----------|------------|-------------|------------|--------------------|------------|-----------------|------------|-------------|------------|-------------------|------------|----------|------------|-------------|------------|---------------|------------|-------------|------------|
| AT       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| AU       |       | PCT1     |       | 23/May/2000 |       | 59627/00           |       | 08/Sep/2003     |       | 05/Feb/2004 |       | 766705            |       | GRT      |       | 05/Feb/2004 |       | 766705        |       | 23/May/2020 |       |
| BE       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| CA       |       | PCT1     |       | 23/May/2000 |       | 2373869            |       |            |       |        |       |              |       | NATF     |       | 13/Nov/2001 |       |          |       | 23/May/2020 |       |
| CH       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| CN       |       | PCT1     |       | 23/May/2000 |       | 00811021.2         |       |            |       |        |       |              |       | NATF     |       | 27/Nov/2001 |       | 00811021.2    |       | 23/May/2020 |       |
| CY       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| CZ       |       | PCT1     |       | 23/May/2000 |       | PV 2001-4235       |       | 17/Apr/2002     |       |        |       |              |       | PUB      |       | 17/Apr/2002 |       |          |       | 23/May/2020 |       |
| DE       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 50002914.8-08     |       | GRT      |       | 16/Jul/2003 |       | 50002914.8-08 |       | 23/May/2020 |       |
| DE       |       | NP1      |       | 27/May/1999 |       | 19925311.0         |       | 30/Nov/2000     |       | 15/Jan/2004 |       | 19925311.0-09     |       | GRT      |       | 15/Jan/2004 |       | 19925311.0-09 |       | 27/May/2019 |       |
| DK       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| EP       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| ES       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| FI       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| FR       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| GB       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00**/**01678 |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| GR       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 20030404214       |       | GRT      |       | 16/Jul/2003 |       | 20030404214   |       | 23/May/2020 |       |
| HK       |       | FPR1     |       | 23/May/2000 |       | 03102710.2         |       | 27/Jun/2003     |       |        |       |              |       | PUB      |       | 27/Jun/2003 |       | 1050492 A     |       | 23/May/2020 |       |
| HU       |       | PCT1     |       | 23/May/2000 |       | P 0201640          |       | 28/Aug/2002     |       |        |       |              |       | PUB      |       | 28/Aug/2002 |       | P 0201640     |       | 23/May/2020 |       |
| IE       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| IT       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| LU       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| MC       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| MX       |       | PCT1     |       | 23/May/2000 |       | PA/A/2001/011998   |       |            |       |        |       |              |       | NATF     |       | 23/Nov/2001 |       |          |       | 23/May/2020 |       |
| NL       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| NO       |       | PCT1     |       | 23/May/2000 |       | 20015745           |       |            |       |        |       |              |       | NATF     |       | 26/Nov/2001 |       |          |       | 23/May/2020 |       |
| NZ       |       | PCT1     |       | 23/May/2000 |       | 515147             |       | 25/Jul/2003     |       | 03/Nov/2003 |       | 515147            |       | GRT      |       | 03/Nov/2003 |       | 515147        |       | 23/May/2020 |       |
| PL       |       | PCT1     |       | 23/May/2000 |       | P-351853           |       |            |       |        |       |              |       | NATF     |       | 26/Nov/2001 |       |          |       | 23/May/2020 |       |
| PT       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |
| SE       |       | EPT1     |       | 23/May/2000 |       | PCT/DE00/01678     |       | 20/Feb/2002     |       | 16/Jul/2003 |       | 1180043           |       | GRT      |       | 16/Jul/2003 |       | 1180043       |       | 23/May/2020 |       |

 

A-8

----

 
| SK |   | PCT1 |   | 23/May/2000 |   | PV 1691-2001 |   | 04/Apr/2002 |   |        |   |       |   | PUB |   | 04/Apr/2002 |   |       |   | 23/May/2020 |   |
|----|--------|------|--------|-------------|--------|--------------|--------|-------------|--------|-------------|--------|------------|--------|-----|--------|-------------|--------|------------|--------|-------------|--------|
| US |   | PCT1 |   | 23/May/2000 |   | 09/979554    |   |        |   | 25/Nov/2003 |   | 6652782 B1 |   | GRT |   | 25/Nov/2003 |   | 6652782 B1 |   | 23/May/2020 |   |
| ZA |   | PCT1 |   | 23/May/2000 |   | 2001/10482   |   |        |   | 25/Jun/2003 |   | 2001/10482 |   | GRT |   | 25/Jun/2003 |   | 2001/10482 |   | 23/May/2020 |   |

 

A-9

----

 

**PatentFamily #52235A**

 
| **Ctry** | ** ** | **Type** | ** ** | **Filing**  | ** ** | **Filing Number** | ** ** | **Publication** | ** ** | **Grant** | ** ** | **Grant  number** | ** ** | **Proc** | ** ** | **Date**    | ** ** | **Nature**         | ** ** | **Exp**     | ** ** |
|----------|------------|----------|------------|-------------|------------|-------------------|------------|-----------------|------------|-----------|------------|-------------------|------------|----------|------------|-------------|------------|--------------------|------------|-------------|------------|
| DE       |       | NP1      |       | 28/Mar/2002 |       | 10215335.3        |       | 16/Oct/2003     |       |      |       |              |       | PUB      |       | 16/Oct/2003 |       | DE 10215335 A1     |       | 28/Mar/2022 |       |
| EP       |       | EPT      |       | 27/Mar/2003 |       | 03745194.5        |       | 22/Dec/2004     |       |      |       |              |       | PUB      |       | 22/Dec/2004 |       | 1487345            |       | 27/Mar/2023 |       |
| JP       |       | PCT      |       | 27/Mar/2003 |       | 2003-579664       |       |            |       |      |       |              |       | NATF     |       | 28/Sep/2004 |       | 2003-579664        |       | 27/Mar/2023 |       |
| US       |       | NP1      |       | 28/Mar/2003 |       | 10/400928         |       | 13/May/2004     |       |      |       |              |       | PUB      |       | 13/May/2004 |       | US-2004-0092820-A1 |       | 28/Mar/2023 |       |
| WO       |       | PCT      |       | 27/Mar/2003 |       | PCT/EP03/03227    |       |            |       |      |       |              |       | FLG      |       | 27/Mar/2003 |       | PCT/EP03/03227     |       |        |       |

 

A-10

----

 

**Appendix B****Third Party Rights under Ultrasound Patents; OtherExceptions**

 

1.)           Non-exclusive,royalty-free, worldwide license under Ultrasound Patent EP 644 776 was grantedto Nycomed Imaging AS (now Amersham Health AS) (“Nycomed”) with the right tosublicense to Affiliates under Settlement Agreement dated as of November 2,1999 between Schering and Nycomed.

 

2.)           Non-exclusivelicense under Ultrasound Patent EP 0744961 B1 was granted to Amersham Health AS(“Amersham”) under Settlement and License Agreement dated as of October 8,2004 between Schering and Amersham.

 

3.)           Non-exclusiveroyalty free license under Ultrasound Patent EP 644777 was granted to BraccoS.p.A. (“Bracco”) under Letter of Understanding dated as of November 14,2000 between Schering and Bracco.

 

B-1

----

 

**Appendix C****Harmonic Imaging Patents**

 

**PatentFamily #51172A1**

 
|   |   | 51172 |   | Licenses List |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|--------|--------|-------|--------|---------------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|

 
| **Ctry** | ** ** | **Type** | ** ** | **Filing**  | ** ** | **Filing Number** | ** ** | **Publication** | ** ** | **Grant**   | ** ** | **Grant Number** | ** ** | **Proc** | ** ** | **Date**    | ** ** | **Nature** | ** ** | **Exp**     | ** ** |
|----------|------------|----------|------------|-------------|------------|-------------------|------------|-----------------|------------|-------------|------------|------------------|------------|----------|------------|-------------|------------|------------|------------|-------------|------------|
| AU       |       | PCT1     |       | 13/Oct/1995 |       | 38424/95          |       | 29/Oct/1998     |       | 11/Feb/1999 |       | 698398           |       | GRT      |       | 11/Feb/1999 |       | 698398     |       | 13/Oct/2015 |       |
| CN       |       | PCT1     |       | 13/Oct/1995 |       | 95195991.3        |       |            |       | 23/Jun/2004 |       | 159753           |       | GRT      |       | 23/Jun/2004 |       | 159753     |       | 13/Oct/2015 |       |
| IL       |       | NP1      |       | 31/Oct/1995 |       | 115832            |       | 24/Aug/1997     |       | 08/Mar/1999 |       | 115832           |       | GRT      |       | 08/Mar/1999 |       | 115832     |       | 31/Oct/2015 |       |
| KR       |       | PCT1     |       | 13/Oct/1995 |       | 10-1997-702870    |       | 01/Dec/1997     |       | 01/Apr/2003 |       | 380126           |       | GRT      |       | 01/Apr/2003 |       | 380126     |       | 13/Oct/2015 |       |
| MX       |       | PCT1     |       | 13/Oct/1995 |       | 972842            |       |            |       | 18/Aug/2000 |       | 198166           |       | GRT      |       | 18/Aug/2000 |       | 198166     |       | 13/Oct/2015 |       |
| NO       |       | PCT1     |       | 13/Oct/1995 |       | 972029            |       |            |       |        |       |             |       | NATF     |       | 30/Apr/1997 |       |       |       | 13/Oct/2015 |       |
| NZ       |       | PCT1     |       | 13/Oct/1995 |       | 295149            |       | 28/Oct/1998     |       | 10/Feb/1999 |       | 295149           |       | GRT      |       | 10/Feb/1999 |       | 295149     |       | 13/Oct/2015 |       |
| TW       |       | NP1      |       | 30/Nov/1995 |       | 84112793          |       | 21/Oct/1997     |       | 11/Feb/1998 |       | NI-090114        |       | GRT      |       | 11/Feb/1998 |       | NI-090114  |       | 30/Nov/2015 |       |
| US       |       | NP1      |       | 01/Nov/1994 |       | 08/332746         |       |            |       | 21/Oct/1997 |       | 5678553          |       | GRT      |       | 21/Oct/1997 |       | 5678553    |       | 01/Nov/2014 |       |
| ZA       |       | NP1      |       | 31/Oct/1995 |       | 95/9217           |       | 31/Jul/1996     |       | 31/Jul/1996 |       | 95/9217          |       | GRT      |       | 31/Jul/1996 |       | 95/9217    |       | 31/Oct/2015 |       |

 

C-1

----

 

**Patent Family #50107**

 
|   |   | 50107 |   | Licenses List |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|--------|--------|-------|--------|---------------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|

 
| **Ctry** | ** ** | **Type** | ** ** | **Filing**  | ** ** | **Filing Number** | ** ** | **Publication** | ** ** | **Grant**   | ** ** | **Grant Number** | ** ** | **Proc** | ** ** | **Date**    | ** ** | **Nature**   | ** ** | **Exp**     | ** ** |
|----------|------------|----------|------------|-------------|------------|-------------------|------------|-----------------|------------|-------------|------------|------------------|------------|----------|------------|-------------|------------|--------------|------------|-------------|------------|
| AT       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | E 68887          |       | GRT      |       | 23/Oct/1991 |       | E 68887      |       | 23/Aug/2009 |       |
| AU       |       | PCT1     |       | 23/Aug/1989 |       | 41824/89          |       | 20/May/1993     |       | 13/Sep/1993 |       | 637059           |       | GRT      |       | 13/Sep/1993 |       | 637059       |       | 23/Aug/2009 |       |
| BE       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | 0357164          |       | GRT      |       | 23/Oct/1991 |       | 0357164      |       | 23/Aug/2009 |       |
| CA       |       | NP1      |       | 31/Aug/1989 |       | 610016            |       |            |       | 19/Mar/1996 |       | 1338175          |       | GRT      |       | 19/Mar/1996 |       | 1338175      |       | 19/Mar/2013 |       |
| CH       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | 0357164          |       | GRT      |       | 23/Oct/1991 |       | 0357164      |       | 23/Aug/2009 |       |
| DE       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | P 58900401.8     |       | GRT      |       | 23/Oct/1991 |       | P 58900401.8 |       | 23/Aug/2009 |       |
| DK       |       | PCT1     |       | 23/Aug/1989 |       | 316/91            |       | 02/Jul/1993     |       | 13/Dec/2004 |       | PR 175571        |       | GRT      |       | 13/Dec/2004 |       | PR 175571    |       | 23/Aug/2009 |       |
| ES       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | 0357164          |       | GRT      |       | 23/Oct/1991 |       | 0357164      |       | 23/Aug/2009 |       |
| FR       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | 0357164          |       | GRT      |       | 23/Oct/1991 |       | 0357164      |       | 23/Aug/2009 |       |
| GB       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | 0357164          |       | GRT      |       | 23/Oct/1991 |       | 0357164      |       | 23/Aug/2009 |       |
| GR       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | 910401550        |       | GRT      |       | 23/Oct/1991 |       | 910401550    |       | 23/Aug/2009 |       |
| IT       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | 0357164          |       | GRT      |       | 23/Oct/1991 |       | 0357164      |       | 23/Aug/2009 |       |
| JP       |       | PCT1     |       | 23/Aug/1989 |       | 1-508941          |       |            |       | 25/Jul/1997 |       | 2677888          |       | GRT      |       | 25/Jul/1997 |       | 2677888      |       | 23/Aug/2009 |       |
| KR       |       | PCT1     |       | 23/Aug/1989 |       | 700928/90         |       |            |       | 23/Feb/1998 |       | 138901           |       | GRT      |       | 23/Feb/1998 |       | 138901       |       | 23/Aug/2009 |       |
| LU       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | 0357164          |       | GRT      |       | 23/Oct/1991 |       | 0357164      |       | 23/Aug/2009 |       |
| NL       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | 0357164          |       | GRT      |       | 23/Oct/1991 |       | 0357164      |       | 23/Aug/2009 |       |
| NO       |       | PCT1     |       | 23/Aug/1989 |       | 910805            |       |            |       |        |       |             |       | FLG      |       | 23/Aug/1989 |       | 910805       |       | 23/Aug/2009 |       |
| SE       |       | EPA1     |       | 23/Aug/1989 |       | 89250017.4        |       | 07/Mar/1990     |       | 23/Oct/1991 |       | 89250017.4       |       | GRT      |       | 23/Oct/1991 |       | 89250017.4   |       | 23/Aug/2009 |       |
| TW       |       | NP1      |       | 23/Oct/1989 |       | 78108117          |       | 01/Jan/1992     |       | 14/Dec/1991 |       | NI-53209         |       | GRT      |       | 14/Dec/1991 |       | NI-53209     |       | 23/Oct/2009 |       |
| US       |       | CWO1     |       | 14/Jun/1993 |       | 076221            |       |            |       | 25/Apr/1995 |       | 5410516          |       | GRT      |       | 25/Apr/1995 |       | 5410516      |       | 25/Apr/2012 |       |
| US       |       | CWO3     |       | 06/Jun/1995 |       | 08/467886         |       |            |       | 16/May/2000 |       | 6064628          |       | GRT      |       | 16/May/2000 |       | 6064628      |       |        |       |
| US       |       | CWO4     |       | 12/Jan/1999 |       | 09/228972         |       |            |       | 07/Mar/2000 |       | 6034922          |       | GRT      |       | 07/Mar/2000 |       | 6034922      |       | 23/Aug/2009 |       |
| US       |       | CWO5     |       | 02/Nov/1999 |       | 09/432123         |       |            |       | 24/Apr/2001 |       | 6221017 B1       |       | GRT      |       | 24/Apr/2001 |       | 6221017 B1   |       | 23/Aug/2009 |       |
| US       |       | CWO6     |       | 20/Dec/2000 |       | 09/740054         |       |            |       | 03/Sep/2002 |       | 6443899 B2       |       | GRT      |       | 03/Sep/2002 |       | 6443899 B2   |       | 23/Aug/2009 |       |
| ZA       |       | NP1      |       | 01/Sep/1989 |       | 89/6738           |       |            |       | 27/Jun/1990 |       | 89/6738          |       | GRT      |       | 27/Jun/1990 |       | 89/6738      |       | 01/Sep/2009 |       |

 

C-2

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