FIRST AMENDMENT TO LEASE
 THIS
FIRST AMENDMENT TO LEASE  Amendment ) 8 SYLVAN WAY, LLC, ( Landlord ) THE MEDICINES COMPANY, ( Tenant ) .
 INTRODUCTORY STATEMENTS:
 WHEREAS, Lease )  Property )
 WHEREAS,
 NOW, THEREFORE,
   (3)
    
    Premises:
    
    173,146 rentable square feet for the Existing Building and
the Additional Building and 2,916 rentable square feet for
the Storage Shed which shall be leased by Tenant in stages
as set forth below:From the Commencement Date until the day immediately
preceding the Phase 2 & 3 Premises Commencement Date:105,211 rentable square feet of space in the Existing
Building (which is all of the space in the Existing
Building), 24,052 rentable square feet on the 3rd
floor of the Additional Building (which is all of the space
on the third (3rd)floor of the Additional
Building) and the Storage Shed containing 2,916 rentable
square feet (collectively the Phase 1 Premises).From the Phase 2 & 3 Commencement Date until the Termination
Date the Premises shall consist of the following: (i) the
Phase 1 Premises, (ii) all of the space




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located on the first floor of the Additional Building,
which is comprised of 21,915 square feet (the Phase 2
Premises"),and (iii) all of the space located on the second
floor of the Additional Building, which is comprised of 21,968
square feet (the Phase 3
Premises").(4)
    
    Term:
    
    Fifteen (15) years.(5)
    
    Rent Date:
    
    November 22, 2008.(6)
    
    Estimated
Commencement
Date for Phase 1
Premises:
    
    December 6, 2008.Phase 2 & 3
Estimated
Commencement
Date:
    
    November 22, 2009 (the Phase 2 & 3 Estimated Commencement
Date")with respect to the Phase 2 and Phase 3 Premises.(7)
    
    Termination Date:
    
    The day immediately preceding the fifteenth
(15th) year anniversary of the Commencement Date, or
such earlier date upon which the Term may expire or be
terminated.(8)
    
    Phase 1 Premises
Commencement Date:
    
    The earlier of: (i) the date Landlord has Substantially
Completed Tenants Finish Work with respect to the Phase 1
Premises, or (ii) the date Landlord would have Substantially
Completed Tenants Finish Work with respect to the Phase 1
Premises, but for a Tenant Delay.Phase 2 & 3 Premises
Commencement: Date:
    
    The earlier of: (i) the date Landlord has Substantially
Completed Tenants Finish Work with respect to the Phase 2
Premises and the Phase 3 Premises, or (ii) the date Landlord
would have Substantially Completed Tenants Finish Work with
respect to the Phase 2 Premises and the Phase 3 Premises, but
for a Tenant Delay. Notwithstanding anything to the contrary
contained in this Lease, in no event shall the Phase 2 & 3
Premises Commencement Date occur prior to November 22, 2009.
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th
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.
    k.
    
    At Tenants expense, Tenant shall provide to Landlord the
Final Plans for the Phase 2 Premises and the Phase 3
Premises on or before:
    
    4/1/091.
    
    Expediter will file for a building permit for the Phase 2
Premises and the Phase 3 Premises not more than ten days
after receipt of construction drawings:
    
    4/13/09 (estimated)m.
    
    Based on the Final Plans and subcontractor bids accepted by
Tenant, Landlord shall provide a final all-in budget for the
Phase 2 Premises and the Phase 3 Premises on or before:
    
    7 weeks after filing
for permitn.
    
    Based on the scope selected by Tenant, Landlord and Tenant
shall agree upon a budget for the Phase 2 Premises and the
Phase 3 Premises on or before:
    
    2 weeks after Landlord
has provided the
all-in budget (m,
above)o.
    
    Subject to Excusable Delays, Landlord will obtain a
building permit for the Phase 2 Premises and the Phase 3
Premises on or before:
    
    12 weeks after filing
for permitp.
    
    Landlord shall Substantially Complete the Tenant Finish
Work for the Phase 2 Premises and the Phase 3 Premises and
shall obtain a Certificate of Occupancy or a Temporary
Certificate of Occupancy on or before:
    
    20 weeks from receipt
of building permit.
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minus " Tenant
Finish Work Allowance ) Allowance.
   
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,
 IN WITNESS WHEREOF,
 REMAINDER OF PAGE LEFT INTENTIONALLY BLANK
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WITNESS:

    Landlord:
8 SYLVAN WAY, LLC
By: Hampshire Partners Fund VI, L.P.,
        its sole member
By: Hampshire Partners LLC,
        its General Partner/s/
Sandria Miele
    
    By:
    /s/
Todd AndersonName:
    Todd AndersonTitle:
    Portfolio Manager WITNESS:

    Tenant:
THE MEDICINES COMPANY/s/
WILLIAM OCONNOR
    
    By:

/s/
CLIVE MEANWELLWILLIAM OCONNOR
    
    
    Name:
    CLIVE  MEANWELLV.P., CAO
    
    
    Title:
    Chairman & CEO 7