OFFICE LEASE AGREEMENT
 BETWEEN
 NORMANDY WALTHAM HOLDINGS, LLC
 (LANDLORD)
 AND
 THE MEDICINES COMPANY
 (TENANT)




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1. Basic Lease Information
    
    
    12. Lease Grant
    
    
    33. Adjustment of Commencement Date; Possession
    
    
    34. Rent
    
    
    45. Compliance with Laws; Use
    
    
    56. Security Deposit
    
    
    67. Building Services
    
    
    68. Leasehold Improvements
    
    
    79. Repairs and Alterations
    
    
    810. Entry by Landlord
    
    
    911. Assignment and Subletting
    
    
    912. Liens
    
    
    1013. Indemnity and Waiver of Claims
    
    
    1114. Insurance
    
    
    1115. Subrogation
    
    
    1216. Casualty Damage
    
    
    1217. Condemnation
    
    
    1318. Events of Default
    
    
    1319. Remedies
    
    
    1320. Limitation of Liability
    
    
    1521. Intentionally Omitted
    
    
    1522. Holding Over
    
    
    1523. Subordination to Mortgages; Estoppel Certificate
    
    
    1624. Notice
    
    
    1625. Surrender of Premises
    
    
    1626. Miscellaneous
    
    
    1627. OFAC Compliance
    
    
    1928. Parking
    
    
    20




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OFFICE LEASE AGREEMENT
 THIS
OFFICE LEASE AGREEMENT Lease NORMANDY WALTHAM HOLDINGS, LLC Landlord THE MEDICINES COMPANY Tenant
 Exhibit A Exhibit B Exhibit C Exhibit D Exhibit E
 1. Basic Lease Information.
 Building Rentable Square Footage of
the Building
 Premises Exhibit A nd Rentable Square Footage of the Premises
 Base Rent
 Months of Term

Annual
Rate Per Square Foot
    Monthly Base Rent1 through 12
    
    $52,122.00
    
    $4,343.5013 through 24
    
    $54,166.00
    
    $4,513.8325 through 36
    
    $56,210.00
    
    $4,684.17
 Tenants Pro Rata Share
 Base Year Base Year Exhibit B
 Fiscal Year
 Term Commencement Date Termination Date




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Improvement Allowance(s)
 Security Deposit
 Guarantor(s)
 Brokers
 Permitted Use
 Notice Addresses
 Landlord
  
  th
  th
  
 Tenant
  Business Days Holidays Building Service Hours




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Landlord Work Work Letter Exhibit C
 Property
 2. Lease Grant.
 Common Areas
 3. Adjustment of Commencement Date; Possession.
 Target Commencement Date Exhibit D Substantially Complete Tenant Delay




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Exhibit
C,
 4. Rent.
 Rent Additional Rent plus
 Exhibit B




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5. Compliance with Laws; Use.
 ADA Law(s)
 Base Building Exhibit E




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6. Security Deposit.
  7. Building Services.




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Electric Service
Provider Alternative Service Provider
  Service Failure th
 8. Leasehold Improvements.
 Leasehold Improvements




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Required Removables
 9. Repairs and Alterations.
 Cable
  Alterations Cosmetic Alteration




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10. Entry by Landlord.
  11. Assignment and Subletting.
 Transfer




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Ownership Change Permitted Transfer Affiliate
 12. Liens.




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13. Indemnity and Waiver of Claims.
 Landlord Related Parties Losses Tenant Related Parties
 14. Insurance.
 Tenants Insurance Tenants Property




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15. Subrogation.
  16. Casualty Damage.
 Casualty (Completion Estimate




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17. Condemnation.
 Taking
 18. Events of Default.
 Default Monetary Default
 19. Remedies.




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Costs of
Reletting




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20. Limitation of Liability.
   21. Intentionally Omitted.
 22. Holding Over.
 st




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23. Subordination to Mortgages; Estoppel Certificate.
 Mortgage Mortgagee
 24. Notice.
 notice
 25. Surrender of Premises.
  26. Miscellaneous.




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Force Majeure




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Hazardous Materials
  27. OFAC Compliance.
 OFAC List Embargoed Person et seq et seq




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Prohibited
Person
  28. Parking




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WITNESS/ATTEST:
    
    
    
    LANDLORD:NORMANDY WALTHAM HOLDINGS, LLC,
a Delaware limited liability company/s/ William OKeefeName (print):
    
    William OKeefe
    
    
    
    By:
    
    /s/  Raymond P. TrevisanRaymond P. Trevisan/s/ Laura Allen
    
    
    
    
    
    Vice PresidentName (print):
    
    Laura Allen
 WITNESS/ATTEST:
    
    
    
    TENANT:THE MEDICINES COMPANY,
a Delaware corporation/s/ Kevin J Raslowsky
    
    
    
    By:
    
    /s/ William OConnorName (print): Kevin J Raslowsky
    
    
    
    
    
    Name:
    
    WILLIAM OCONNORTitle:
    
    CHIEF ACCOUNTING OFFICER/s/ Martin JohanssonName (print): Martin Johansson
    
    
    
    Tenants Tax ID Number (SSN or FEIN)




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EXHIBIT A
 OUTLINE AND LOCATION OF PREMISES
 
 A-1




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EXHIBIT B
 EXPENSES AND TAXES
 NORMANDY
WALTHAM HOLDINGS, LLC Landlord THE MEDICINES
COMPANY Tenant
 Payments.
 Expense Excess Tax
Excess
   Expenses
 B-1




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Payback Period
  B-2




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Taxes Taxes
 Audit Rights (Review Notice)
 B-3




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Objection Notice)
 B-4




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EXHIBIT C
 WORK LETTER
 ( Landlord ) ( Tenant ) .
 Premises
 Worklist) Landlord Work.
 WORK LIST
       C-1




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EXHIBIT D
 COMMENCEMENT LETTER
 (EXAMPLE)
 DateTenantAddress
 Landlord Tenant
    
 
   
  
 D-1




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By:Name:Title:Date: D-2




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EXHIBIT E
 BUILDING RULES AND REGULATIONS
  1.
    
    Sidewalks, doorways, vestibules, halls, stairways and other similar areas shall not be
obstructed by Tenant or used by Tenant for any purpose other than ingress and egress to and from
the Premises. No rubbish, litter, trash, or material shall be placed, emptied, or thrown in those
areas. At no time shall Tenant permit Tenants employees to loiter in Common Areas or elsewhere
about the Building or Property.2.
    
    Plumbing fixtures and appliances shall be used only for the purposes for which designed and no
sweepings, rubbish, rags or other unsuitable material shall be thrown or placed in the fixtures or
appliances. Damage resulting to fixtures or appliances by Tenant, its agents, employees or invitees
shall be paid for by Tenant and Landlord shall not be responsible for the damage.
 3.
    
    No signs, advertisements or notices shall be painted or affixed to windows, doors or other
parts of the Building, except those of such color, size, style and in such places as are first
approved in writing by Landlord, which approval shall not be unreasonably withheld,
conditioned or delayed. All tenant identification and suite numbers at the entrance to the
Premises shall be installed by Landlord, at Tenants reasonable cost and expense, using the
standard graphics for the Building. Except in connection with the hanging of lightweight
pictures and wall decorations, no nails, hooks or screws shall be inserted into any part of
the Premises or Building except by the Building maintenance personnel without Landlords prior
approval, which approval shall not be unreasonably withheld, conditioned or delayed.
 4.
    
    Landlord may provide and maintain in the first floor (main lobby) of the Building an
alphabetical directory board or other directory device listing tenants and no other directory
shall be permitted unless previously consented to by Landlord in writing.
 5.
    
    Tenant shall not place any lock(s) on any door in the Premises or Building without Landlords
prior written consent, which consent shall not be unreasonably withheld, and Landlord shall
have the right at all times to retain and use keys or other access codes or devices to all
locks within and into the Premises. A reasonable number of keys to the locks on the entry
doors in the Premises shall be furnished by Landlord to Tenant at Tenants cost and Tenant
shall not make any duplicate keys. All keys shall be returned to Landlord at the expiration or
early termination of the Lease.
 6.
    
    All contractors, contractors representatives and installation technicians performing work in
the Building shall be subject to Landlords prior approval, which approval shall not be
unreasonably withheld, and shall be required to comply with Landlords standard rules, regulations,
policies and procedures, which may be revised from time to time. Landlord has no obligation to
allow any particular telecommunication service provider to have
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access to the Buildings or to the Premises. If Landlord permits access, Landlord may condition the
access upon the payment to Landlord by the service provider of fees assessed by Landlord in
Landlords sole discretion.7.
    
    Movement in or out of the Building of furniture or office equipment, or dispatch or
receipt by Tenant of merchandise or materials requiring the use of elevators, stairways, lobby
areas or loading dock areas, shall be restricted to hours reasonably designated by Landlord.
Tenant shall obtain Landlords prior approval by providing a detailed listing of the activity,
which approval shall not be unreasonably withheld, conditioned, or delayed. If approved by
Landlord, the activity shall be under the supervision of Landlord and performed in the manner
reasonably required by Landlord. Tenant shall assume all risk for damage to articles moved and
injury to any persons resulting from the activity. If equipment, property, or personnel of
Landlord or of any other party is damaged or injured as a result of or in connection with the
activity, Tenant shall be solely liable for any resulting damage, loss or injury.8.
    
    Landlord shall have the right to approve the weight, size, or location of heavy equipment
or articles in and about the Premises, which approval shall not be unreasonably withheld. Damage
to the Building by the installation, maintenance, operation, existence or removal of Tenants
Property shall be repaired at Tenants sole expense.9.
    
    Corridor doors, when not in use, shall be kept closed.10.
    
    Tenant shall not: (1) make or permit any improper, objectionable or unpleasant noises or odors
in the Building, or otherwise interfere in any way with other tenants or persons having business
with them; (2) solicit business or distribute or cause to be distributed, in any portion of the
Building, handbills, promotional materials or other advertising; or (3) conduct or permit other
activities in the Building that might, in Landlords sole opinion, constitute a nuisance.11.
    
    No animals, except those assisting handicapped persons, shall be brought into the Building or
kept in or about the Premises.12.
    
    No inflammable, explosive or dangerous fluids or substances shall be used or kept by
Tenant in the Premises, Building or about the Property, except for those substances as are
typically found in similar premises used for general office purposes and are being used by Tenant
in a safe manner and in accordance with all applicable Laws. Tenant shall not, without Landlords
prior written consent, use, store, install, spill, remove, release or dispose of, within or about
the Premises or any other portion of the Property, any asbestos-containing materials or any solid,
liquid or gaseous material now or subsequently considered toxic or hazardous under the provisions
of 42 U.S.C. Section 9601 et seq., M.G.L. c. 21C, M.G.L. c. 21E or any other applicable
environmental Law which may now or later be in effect. Tenant shall comply with all Laws
pertaining to and governing the use of these materials by Tenant and shall remain solely liable
for the costs of abatement and removal.13.
    
    Tenant shall not use or occupy the Premises in any manner or for any purpose which might
injure the reputation or impair the present or future value of the Premises or the Building.
Tenant shall not use, or permit any part of the Premises to be used for lodging, sleeping or for
any illegal purpose.
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14.
    
    Tenant shall not take any action which would violate Landlords labor contracts or which
would cause a work stoppage, picketing, labor disruption or dispute or interfere with
Landlords or any other tenants or occupants business or with the rights and privileges of
any person lawfully in the Building (Labor Disruption).Tenant shall take the actions
necessary to resolve the Labor Disruption, and shall have pickets removed and, at the request
of Landlord, immediately terminate any work in the Premises that gave rise to the Labor
Disruption, until Landlord gives its written consent for the work to resume. Tenant shall have
no claim for damages against Landlord or any of the Landlord Related Parties nor shall the
Commencement Date of the Term be extended as a result of the above actions.
 15.
    
    Tenant shall not install, operate or maintain in the Premises or in any other area of the
Building, electrical equipment that would overload the electrical system beyond its capacity
for proper, efficient and safe operation as determined solely by Landlord. Tenant shall not
furnish cooling or heating to the Premises, including, without limitation, the use of
electronic or gas heating devices, without Landlords prior written consent. Tenant shall not
use more than its proportionate share of telephone lines and other telecommunication
facilities available to service the Building.
 16.
    
    Tenant shall not operate or permit to be operated a coin or token operated vending machine or
similar device (including, without limitation, telephones, lockers, toilets, scales, amusement
devices and machines for sale of beverages, foods, candy, cigarettes and other goods), except
for machines for the exclusive use of Tenants employees and invitees.
 17.
    
    Bicycles and other vehicles are not permitted inside the Building or on the walkways outside
the Building, except in areas designated by Landlord.
 18.
    
    Landlord may from time to time adopt reasonable systems and procedures for the security and
safety of the Building, its occupants, entry, use and contents. Tenant, its agents, employees,
contractors, guests and invitees shall comply with Landlords reasonable systems and
procedures.
 19.
    
    Landlord shall have the right to prohibit the use of the name of the Building or any other
publicity by Tenant that in Landlords sole opinion may impair the reputation of the Building
or its desirability. Upon written notice from Landlord, Tenant shall refrain from and
discontinue such publicity immediately.20.
    
    Neither Tenant nor its agents, employees, contractors, guests or invitees shall smoke or permit
smoking in the Common Areas, unless a portion of the Common Areas have been declared a designated
smoking area by Landlord, nor shall the above parties allow smoke from the Premises to emanate into
the Common Areas or any other part of the Building. Landlord shall have the right to designate the
Building (including the Premises) as a non-smoking building.21.
    
    Landlord shall have the right to designate and approve standard window coverings for the
Premises and to establish rules to assure that the Building presents a uniform exterior appearance.
Tenant shall ensure, to the extent reasonably practicable, that window coverings are closed on
windows in the Premises while they are exposed to the direct rays of the sun.
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22.
    
    Deliveries to and from the Premises shall be made only at the times in the areas and through
the entrances and exits reasonably designated by Landlord. Tenant shall not make deliveries to
or from the Premises in a manner that might Interfere with the use by any other tenant of its
premises or of the Common Areas, any pedestrian use, or any use which is inconsistent with
good business practice.23.
    
    The work of cleaning personnel shall not be hindered by Tenant after 5:30 P.M., and cleaning
work may be done at any time when the offices are vacant. Windows, doors and fixtures may be
cleaned at any time. Tenant shall provide adequate waste and rubbish receptacles to prevent
unreasonable hardship to the cleaning service.
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