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                                                                    EXHIBIT 10.1

                         DATATRAK INTERNATIONAL, INC.
           AMENDED AND RESTATED OUTSIDE DIRECTOR STOCK OPTION PLAN

     (f/k/a Amended and Restated 1999 Outside Director Stock Option Plan)

      DATATRAK International, Inc., hereinafter called the "Company," hereby
adopts a stock option plan for eligible Directors of the Company pursuant to the
following terms and provisions:

      1. PURPOSE OF THE PLAN. The purpose of this plan, hereinafter called the
"Plan," is to provide additional incentive to those Directors of the Company who
are not employees of the Company or any of its subsidiaries or affiliates by
encouraging them to acquire a new or an additional share ownership in the
Company, thus increasing their proprietary interest in the Company's business
and providing them with an increased personal interest in the Company's
continued success and progress. These objectives will be promoted through the
grant of options to acquire the Company's Common Shares, without par value per
share (the "Common Shares"), pursuant to the terms of the Plan. Only those
Directors who meet the qualifications stated above are eligible for and shall
receive options under this Plan.

      2. EFFECTIVE DATE OF THE PLAN. The Plan shall become effective as of
September 22, 1999, subject to approval by holders of shares representing a
majority of the outstanding voting stock of the Company present at a meeting of
shareholders called for that purpose.

      3. COMMON SHARES SUBJECT TO THE PLAN. The Common Shares to be issued upon
the exercise of the options granted under the Plan shall be Common Shares of the
Company. Either treasury or authorized and unissued Common Shares, or both, as
the Board of Directors shall from time to time determine, may be so issued.
Common Shares which are the subject of any lapsed, expired or terminated options
may be made available for re-offering under the Plan. If an option granted under
this Plan is exercised pursuant to the terms and conditions of subsection 5(b),
any Common Shares which are the subject thereof shall not thereafter be
available for re-offering under the Plan.

      Subject to the provisions of the next succeeding paragraph of this Section
3, the aggregate number of Common Shares for which options may be granted under
the Plan shall be Five Hundred Fifty Thousand (550,000) Common Shares.

      In the event that, subsequent to the date of adoption of the Plan by the
Board of Directors, the Common Shares should, as a as a result of a stock split,
stock dividend, combination or exchange of shares, exchange for other
securities, reclassification, reorganization, redesignation, merger,
consolidation, recapitalization or other such change, be increased or decreased
or changed into or exchanged for a different number or kind of shares of stock
or other securities of the Company or of another corporation, then (i) there
shall automatically be substituted for each Common Share subject to an
unexercised option (in whole or in part) granted under the Plan, each Common
Share available for additional grants of options under the Plan and each Common
Share made available for grant to each eligible Director pursuant to Section 4
hereof, the number and kind of shares of stock or other securities into which
each outstanding Common Share shall be changed or for which each such Common
Share shall be exchanged, (ii) the option price per Common Share or unit of
securities shall be increased or decreased proportionately so that the aggregate
purchase price for the securities subject to the option shall remain the same as
immediately prior to such event, and (iii) the Board of Directors shall make
such other adjustments as may be appropriate and equitable to prevent
enlargement or dilution of option rights. Any such adjustment may provide for
the elimination of fractional shares.

      4. GRANT OF OPTIONS.

            a. AUTOMATIC GRANTS. Subject to the terms of the Plan, each eligible
Director shall be granted non-qualified stock options to purchase (i) 12,500
Common Shares as of the date such Director is first appointed or elected to the
Board of Directors, (ii) 6,250 Common Shares at each annual meeting of


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the shareholders of the Company so long as he or she is an eligible Director,
and (iii) 1,000 Common Shares at each annual meeting of the shareholders of the
Company so long as he or she is an eligible Director and is then-serving as a
Chairperson of a standing committee of the Board of Directors.

            b. UPON RETIREMENT. Subject to the terms of the Plan, in the event a
Director has served for at least five (5) years as a Director of the Company,
then upon retirement from the Board such Director shall be granted a
non-qualified stock option for 6,250 Common Shares as of the date of such
retirement, provided that such Director agrees to be available for limited
consulting for a period of one year after his retirement at the request of
either the Chief Executive Officer of the Company or the Board of Directors.

            c. OPTION PRICE. The price at which each Common Share may be
purchased pursuant to an option granted under the Plan shall be equal to the
"fair market value" (as determined pursuant to Section 7) for each such share as
of the date on which the option is granted (the "Date of Grant"), but in no
event shall such price be less than the par value of such Common Shares.
Anything contained in this subsection (c) to the contrary notwithstanding, in
the event that the number of Common Shares subject to any option is adjusted
pursuant to Section 3, a corresponding adjustment shall be made in the price at
which the Common Shares subject to such option may thereafter be purchased.

            d. DURATION OF OPTIONS. Each option granted under the Plan shall
expire and all rights to purchase Common Shares pursuant thereto shall cease on
the date (the "Expiration Date") which shall be the tenth anniversary of the
Date of Grant of such option.

            e. VESTING OF OPTIONS. For the annual grants of options to purchase
6,250 Common Shares and 1,000 Common Shares for Chairpersons, one hundred
percent (100%) of each such option granted under the Plan shall become fully
vested and exercisable on the date of the first annual meeting of the Company's
shareholders following the Date of Grant. For the grants of 12,500 Common Shares
upon the initial appointment or election of an eligible Director or for grants
of 6,250 Common Shares upon the upon the retirement of a Director, one hundred
percent (100%) of each such option granted under the Plan shall become fully
vested and exercisable on the first anniversary of the Date of Grant.

      5. OPTION PROVISIONS.

            a. LIMITATION ON EXERCISE AND TRANSFER OF OPTIONS. Each option
agreement shall be binding upon and inure to the benefit of any successor of the
Company and the heirs, estate, personal representative and transferees of the
optionee. All or any portion of an option shall be transferable by the optionee,
in whole at any time or in part from time to time, to (i) any member of the
optionee's Immediate Family, (ii) any trust whose beneficiaries consist solely
of the optionee and/or members of the optionee's Immediate Family, and (iii) any
person or entity who is an "affiliate" of the optionee (as such term is defined
in Rule 501(b) of Regulation D promulgated under the Securities Act of 1933).
Notwithstanding the foregoing, the Company shall be under no obligation to
record any such transfer upon the books of the Company and may treat the
optionee as the record and beneficial owner thereof for all purposes until such
time as: (a) the transferor delivers to the Company a fully executed assignment
of option in the form attached as Exhibit A to the option agreement; (b) the
transferee delivers to the Company a fully executed joinder to the option
agreement in the form attached as Exhibit B to the option agreement; and (c)
that the transferor and transferee establish, to the reasonable satisfaction of
the Company, that such a transfer is permitted under applicable provisions of
the federal securities laws. For purposes of this Plan, "Immediate Family" means
a person's parents, siblings, spouse, children or grandchildren or any of the
foregoing persons. No option granted hereunder may be pledged or hypothecated,
nor shall any such option be subject to execution, attachment or similar
process.

            b. EXERCISE OF OPTION. Each option granted hereunder may be
exercised in whole or in part (to the maximum extent then exercisable) from time
to time during the option period, but this right of exercise shall be limited to
whole shares. Options shall be exercised by the optionee giving written notice
to the Chief Financial Officer of the Company at its principal business office,
by certified mail, return receipt requested, of the optionee's intention to
exercise the same and the number of shares with respect to which the option is
being exercised (the "Notice of Exercise of Option") accompanied by full payment
of


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the purchase price in cash or in whole or in part in Common Shares having a
fair market value on the date the option is exercised equal to that portion of
the purchase price for which payment in cash is not made. Such Notice of
Exercise of Option shall be deemed delivered upon deposit into the mails.

            c. TERMINATION OF DIRECTORSHIP FOR CAUSE. In the event that such
Director is removed in accordance with the Company's Articles of Incorporation,
as amended, then all options shall terminate three (3) months after the
effective date of termination of his or her Directorship and neither he nor she
nor any other person shall have any right after such date to exercise all or any
part of such option.

            d. ACCELERATION OF EXERCISE OF OPTION IN CERTAIN EVENTS.
Notwithstanding anything to the contrary described in the Plan, in the event of
a "change in control," the eligible Director shall have the immediate right and
option (notwithstanding the provisions of paragraph 4 hereof) to exercise the
option with respect to all Common Shares covered by the option, which exercise,
if made, shall be irrevocable. The term "change in control" shall mean: (i) the
receipt by the Company of a Schedule 13D or other advice indicating that a
person, or any member of a "group," is the "beneficial owner" (as those terms
are defined in Rule 13d-3 under the Securities Exchange Act of 1934) of twenty
percent (20%) or more of the voting power of the Company; (ii) the first
purchase of shares pursuant to a tender offer or exchange (other than a tender
offer or exchange by the Company or its affiliates) for all or any amount of
Common Shares or any class or any securities convertible into such Common
Shares, the results of which would make the offeror and/or its affiliates the
beneficial owners of twenty percent (20%) or more of the voting power of the
Company; (iii) the date of the approval by shareholders of the Company of an
agreement providing for any consolidation or merger of the Company in which the
Company will not be the continuing or surviving corporation or pursuant to which
shares of capital stock of any class, or any securities convertible into such
capital stock, of the Company would be converted into cash, securities, or other
property, other than a merger or consolidation of the Company with an affiliate
of the Company or in which the holders of all of the shares of all classes of
the Company's capital stock immediately prior to the merger or consolidation
would own at least a majority of the voting power of the surviving corporation
(or the direct or indirect parent company of the surviving corporation)
immediately after the merger or consolidation; (iv) the date of the approval by
shareholders of the Company of any sale, lease, exchange, or other transfer (in
one transaction or a series of related transactions) of all or substantially all
the assets of the Company; or (v) the adoption of any plan or proposal for the
liquidation (but not a partial liquidation) or dissolution of the Company.

            e. OPTION AGREEMENTS. Options granted under the Plan shall be
subject to the further terms and provisions of an option agreement the execution
of which by each optionee shall be a condition to the receipt of an option.

            f. CERTAIN RESTRICTIONS. Notwithstanding anything in the foregoing
to the contrary, the Company shall not, unless approved by the holders of a
majority of the shares present and entitled to vote at a duly convened meeting
of shareholders: (i) grant any stock option, including stock appreciation right,
with an exercise price that is less than one hundred percent (100%) of the fair
market value of the underlying stock on the date of grant; or (ii) reduce the
exercise price of any stock option, including stock appreciation right,
outstanding or to be granted in the future; cancel and re-grant options at a
lower exercise price (including entering into any "6 month and 1 day"
cancellation and re-grant program), whether or not the canceled options are put
back into the available pool for grant; replace out-of-the-money options with
restricted stock in an exchange, buy-back or other program; or replace any
options with new options having a lower exercise price or accelerated vesting
schedule in an exchange, buy-back or other program. The prohibitions set forth
in subsections 5(f)(i) and 5(f)(ii) above may not be further amended or repealed
without the affirmative vote of the holders of a majority of the shares present
and entitled to vote at a duly convened meeting of shareholders.

      6. INVESTMENT REPRESENTATION; APPROVALS AND LISTING. The options to be
granted hereunder shall be further conditioned upon receipt of the following
investment representation from the optionee:

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      "I further agree that any Common Shares of DATATRAK International, Inc.
      (the "Company") which I may acquire by virtue of this option shall be
      acquired for investment purposes only and not with a view to distribution
      or resale; provided, however, that this restriction shall become
      inoperative in the event that the said Common Shares subject to this
      option shall be registered under the Securities Act of 1933, as amended,
      or in the event that the offer or sale of the Common Shares subject to
      this option may be lawfully made without registration of the said Common
      Shares under the Securities Act of 1933, as amended, as established to the
      satisfaction of the Company."

The Company shall not be required to issue any certificate or certificates for
Common Shares upon the exercise of an option granted under the Plan prior to (i)
the obtaining of any approval from any governmental agency which the Company
shall, in its sole discretion, determine to be necessary or advisable, (ii) the
admission of such Common Shares to listing on any national securities exchange
on which the Common Shares may be listed, (iii) the completion of any
registration or other qualification of the Common Shares under any state or
federal law or ruling or regulations of any governmental body which the Company
shall, in its sole discretion, determine to be necessary or advisable or the
determination by the Company, in its sole discretion, that any registration or
other qualification of the Common Shares is not necessary or advisable, and (iv)
the obtaining of an investment representation from the optionee in the form
stated above or in such other form as the Company, in its sole discretion, shall
determine to be adequate.

      7. GENERAL PROVISIONS. For all purposes of this Plan, the fair market
value of a Common Share shall be determined as follows: so long as the Common
Shares of the Company are listed upon an established stock exchange or exchanges
or contained in the Nasdaq National Market System or the Nasdaq SmallCap Market
System (in either case, "Nasdaq"), such fair market value shall be determined to
be the highest closing sale price of such Common Shares on such stock exchange
or exchanges or Nasdaq the trading day on which the option is granted (or the
date the Common Shares are tendered as payment, in the case of determining fair
market value for that purpose) or if no sale of such Common Shares shall have
been made on any stock exchange or Nasdaq on that day, then on the closest
preceding day on which there was a sale of such Common Shares; and during any
period of time as such Common Shares are not listed upon an established stock
exchange or traded on Nasdaq, the fair market value per share shall either be
(i) the mean between dealer "Bid" and "Ask" prices of such Common Shares in the
over-the-counter market on the trading day immediately prior to the day the
option is granted (or the day the Common Shares are tendered as payment, in the
case of determining fair market value for that purpose), as reported by the
National Association of Securities Dealers, Inc., or (ii) the value determined
by the Board of Directors, excluding for that purpose, the votes of any eligible
Directors.

      The liability of the Company under the Plan and any distribution of Common
Shares made hereunder is limited to the obligations set forth herein with
respect to such distribution and no term or provision of the Plan shall be
construed to impose any liability on the Company in favor of any person with
respect to any loss, cost or expense which the person may incur in connection
with or arising out of any transaction in connection with the Plan, including,
but not limited to, any liability to any federal, state, or local tax authority
and/or any securities regulatory authority.

      Nothing in the Plan or in any option agreement shall confer upon any
optionee any right to continue as a Director, or to be entitled to any
remuneration or benefits not set forth in the Plan or such option.

      Nothing contained in the Plan or in any option agreement shall be
construed as entitling any optionee to any of the rights of a shareholder as a
result of the grant of an option until such time as Common Shares are actually
issued to such optionee pursuant to the exercise of an option.

      The Plan may be assumed by the successors and assigns of the Company.

      The Plan shall not be amended more than once every six (6) months, other
than to comport with changes in the Internal Revenue Code, the Employee
Retirement Income Security Act, or the rules thereunder.

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      The cash proceeds received by the Company from the issuance of Common
Shares pursuant to the Plan will be used for general corporate purposes or in
such other manner as the Board of Directors deems appropriate.

      The expense of administering the Plan shall be borne by the Company.

      The captions and section numbers appearing in the Plan are inserted only
as a matter of convenience. They do not define, limit, construe or describe the
scope or intent of the provisions of the Plan.

      8. TERMINATION OF THE PLAN. The Plan shall terminate ten (10) years from
the date of its original adoption by the Board of Directors of the Company and
thereafter no options shall be granted hereunder. All options outstanding at the
time of termination of the Plan shall continue in full force and effect in
accordance with and subject to their terms and the terms and conditions of the
Plan.

      9. TAXES. Appropriate provisions shall be made for all taxes required to
be withheld and/or paid in connection with the options or the exercise thereof,
and the transfer of Common Shares pursuant thereto, under the applicable laws or
other regulations of any governmental authority, whether federal, state, or
local and whether domestic or foreign. In its discretion, the Company may permit
the optionee to satisfy such withholding requirements by (a) the Company
withholding from issuance to the optionee such number of Common Shares otherwise
issuable upon exercise of the option as the Company and the optionee may agree,
provided, however, that the optionee must have had on file with the Company, for
at least six (6) months prior thereto, an effective standing election to satisfy
said optionee's tax withholding obligations in such a fashion, which election
form by its terms shall not be revocable or amendable for at least six (6)
months, or (b) with the consent of the Board, in whole or in part, in Common
Shares having a fair market value on the date the option is exercised equal to
that portion of the withholding obligation for which payment in cash is not
made.

      10. CHANGES IN GOVERNING RULES AND REGULATIONS. All references herein to
the Internal Revenue Code of 1986, as amended, or sections thereof, or to rules
and regulations of the Department of Treasury or of the Securities and Exchange
Commission, shall mean and include the Code sections thereof and such rules and
regulations as are now in effect or as they may be subsequently amended,
modified, substituted or superseded.



Adopted as of June 2, 2004