exv4w1






Exhibit 4.1




EXECUTION VERSION




WARRANT



THE SECURITIES EVIDENCED BY THIS WARRANT HAVE NOT BEEN REGISTERED UNDER THE U.S. SECURITIES ACT OF
1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY OTHER APPLICABLE SECURITIES LAWS AND HAVE
BEEN ISSUED IN RELIANCE UPON AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT
AND SUCH OTHER SECURITIES LAWS. NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN MAY
BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED, HYPOTHECATED OR OTHERWISE DISPOSED
OF, EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR ANY OTHER
APPLICABLE SECURITIES LAWS, OR PURSUANT TO A TRANSACTION WHICH IS EXEMPT FROM, OR NOT SUBJECT TO,
SUCH REGISTRATION.




August 4, 2008          




     Warrant to Purchase up to 400,000 shares of Common Stock of EPIX Pharmaceuticals, Inc. (the
“Company”).



     In consideration for Kingsbridge Capital Limited (the “Investor”) agreeing to enter
into that certain Common Stock Purchase Agreement, dated as of the date hereof, between the
Investor and the Company (the “Agreement”), the Company hereby agrees that the Investor or
any other Warrant Holder (as defined below) is entitled, on the terms and conditions set forth
below, to purchase from the Company at any time during the Exercise Period (as defined below) up to
400,000 fully paid and non-assessable shares of common stock, par value $0.01 per share, of the
Company (the “Common Stock”) at the Exercise Price (as defined below), as the same may be
adjusted from time to time pursuant to Section 6 hereof. The resale of the shares of Common Stock
or other securities issuable upon exercise or exchange of this Warrant is subject to the provisions
of the Registration Rights Agreement. Capitalized terms used herein and not otherwise defined
shall have the meanings given them in the Agreement.



     Section 1. Definitions.



          “Affiliate” shall mean any Person that, directly or indirectly through one or more
intermediaries, controls or is controlled by, or is under direct or indirect common control with
any other Person. For the purposes of this definition, “control,” when used with respect
to any Person, means the power to direct the management and policies of such Person, directly or
indirectly through the ownership of voting securities, and the term “controls” and
“controlled” have meanings correlative to the foregoing.




          “Closing Price” as of any particular day shall mean the closing price per share of the
Company’s Common Stock as reported by Bloomberg L.P. on such day.




          “Exercise Period” shall mean that period beginning six months after the date of this
Warrant and continuing until the earlier of (i) the expiration of the five-year period thereafter,
or (ii) a Funding Default, subject in each case to earlier termination in accordance with Section 6
hereof.




 









 








          “Exercise Price” as of the date hereof shall mean $2.4925.




          “Funding Default” shall mean a failure by Investor to accept a Draw Down Notice made
by the Company and to acquire and pay for the Shares in accordance therewith within three (3)
Trading Days following the delivery of such Shares to the Investor, provided such Draw Down Notice
was made in accordance with the terms and conditions of the Agreement (including the satisfaction
or waiver of the conditions to the obligation of the Investor to accept a Draw Down set forth in
Article VII of the Agreement), provided further, that such failure was reasonably within the
control of the Investor.




          “Per Share Warrant Value” shall mean the difference resulting from subtracting the
Exercise Price from the Closing Price on the Trading Day immediately preceding the Exercise Date.




          “Person” shall mean an individual, a corporation, a partnership, a limited liability
company, an association, a trust or other entity or organization, including a government or
political subdivision or an agency or instrumentality thereof.




          “Principal Market” shall mean the NASDAQ Global Select Market, the NASDAQ Global
Market, the NASDAQ Capital Market, the American Stock Exchange or the New York Stock Exchange,
whichever is at the time the principal trading exchange or market for the Common Stock.




          “SEC” shall mean the United States Securities and Exchange Commission.




          “Trading Day” shall mean any day other than a Saturday or a Sunday on which the
Principal Market is open for trading in equity securities.




          “Warrant Holder” shall mean the Investor or any permitted assignee or permitted
transferee of all or any portion of this Warrant.




          “Warrant Shares” shall mean those shares of Common Stock received upon exercise of
this Warrant.




     Section 2. Exercise.



          (a) Method of Exercise. This Warrant may be exercised in whole or in part (but not as
to a fractional share of Common Stock), at any time and from time to time during the Exercise
Period, by the Warrant Holder by surrender of this Warrant, with the form of exercise attached
hereto as Exhibit A completed and duly executed by the Warrant Holder (the “Exercise
Notice”), to the Company at the address set forth in Section 10.4 of the Agreement, accompanied
by payment of the Exercise Price multiplied by the number of shares of Common Stock for which this
Warrant is being exercised (the “Aggregate Exercise Price”). The later of the date on
which an Exercise Notice or payment of the Exercise Price (unless this Warrant is exercised in
accordance with Section 2(c) below) is received by the Company in accordance with this clause
(a) shall be deemed an “Exercise Date.”




 









 








          (b) Payment of Aggregate Exercise Price. Subject to paragraph (c) below, payment of
the Aggregate Exercise Price shall be made by wire transfer of immediately available funds to an
account designated by the Company. If the amount of the payment received by the Company is less
than the Aggregate Exercise Price, the Warrant Holder will be notified of the deficiency and shall
make payment in that amount within three (3) Trading Days. In the event the payment exceeds the
Aggregate Exercise Price, the Company will refund the excess to the Warrant Holder within five (5)
Trading Days of receipt.




          (c) Cashless Exercise. In the event that the Warrant Shares to be received by the
Warrant Holder upon exercise of the Warrant may not be resold pursuant to an effective registration
statement or an exemption to the registration requirements of the Securities Act and applicable
state laws, the Warrant Holder may, as an alternative to payment of the Aggregate Exercise Price
upon exercise in accordance with paragraph (b) above, elect to effect a cashless exercise by so
indicating on the Exercise Notice and including a calculation of the number of shares of Common
Stock to be issued upon such exercise in accordance with the terms hereof (a “Cashless
Exercise”). If a registration statement on Form S-3 under the Securities Act or such other
form as deemed appropriate by counsel to the Company for the registration for the resale by the
Warrant Holder of (x) the shares of Common Stock of the Company that may be purchased under the
Agreement, (y) the Warrant Shares, or (z) any securities issued or issuable with respect to any of
the foregoing by way of exchange, stock dividend or stock split or in connection with a combination
of shares, recapitalization, merger, consolidation or other reorganization or otherwise, has been
declared effective by the SEC and remains effective, the Company may, in its sole discretion,
permit the Warrant Holder to effect a Cashless Exercise or require the Warrant Holder to pay the
Exercise Price of the Warrant Shares being purchased by the Warrant Holder under this Warrant. In
the event of a Cashless Exercise, the Warrant Holder shall receive that number of shares of Common
Stock determined by (i) multiplying the number of Warrant Shares for which this Warrant is being
exercised by the Per Share Warrant Value and (ii) dividing the product by the Closing Price on the
Trading Day immediately preceding the Exercise Date, rounded to the nearest whole share. The
Company shall cancel the total number of Warrant Shares equal to the excess of the number of the
Warrant Shares for which this Warrant is being exercised over the number of Warrant Shares to be
received by the Warrant Holder pursuant to such Cashless Exercise.




          (d) Replacement Warrant. In the event that the Warrant is not exercised in full, the
number of Warrant Shares shall be reduced by the number of such Warrant Shares for which this
Warrant is exercised, and the Company, at its expense, shall forthwith issue and deliver to or upon
the order of the Warrant Holder a new Warrant of like tenor in the name of the Warrant Holder,
reflecting such adjusted number of Warrant Shares.




     Section 3. Ten Percent Limitation. The Warrant Holder may not exercise this Warrant
such that the number of Warrant Shares to be received pursuant to such exercise aggregated with all
other shares of Common Stock that are then beneficially owned or deemed to be beneficially owned by
the Warrant Holder would result in the Warrant Holder owning more than 9.9% of all of such Common
Stock as would be outstanding on such Exercise Date, as determined in accordance with Section 13(d)
of the Exchange Act.



 









 





     Section 4. Delivery of Warrant Shares.



          (a) Subject to the terms and conditions of this Warrant, as soon as practicable after the
exercise of this Warrant in full or in part, and in any event within ten (10) Trading Days
thereafter, the Company at its expense (including, without limitation, the payment by it of any
applicable issue taxes) will cause to be issued in the name of and delivered to the Warrant Holder,
or as the Warrant Holder may lawfully direct, a certificate or certificates for, or make deposit
with the Depositary Trust Company via book-entry of, the number of validly issued, fully paid and
non-assessable Warrant Shares to which the Warrant Holder shall be entitled on such exercise,
together with any other stock or other securities or property (including cash, where applicable) to
which the Warrant Holder is entitled upon such exercise in accordance with the provisions hereof.




          (b) This Warrant may not be exercised as to fractional shares of Common Stock. In the event
that the exercise of this Warrant, in full or in part, would result in the issuance of any
fractional share of Common Stock, then in such event the Warrant Holder shall receive the number of
shares rounded down to the nearest whole share.




     Section 5. Representations, Warranties and Covenants of the Company.



          (a) The Warrant Shares, when issued in accordance with the terms hereof, will be duly
authorized and, when paid for or issued in accordance with the terms hereof, shall be validly
issued, fully paid and non-assessable.




          (b) The Company shall take all commercially reasonable action and proceedings as may be
required and permitted by applicable law, rule and regulation for the legal and valid issuance of
this Warrant and the Warrant Shares to the Warrant Holder.




          (c) The Company has authorized and reserved for issuance to the Warrant Holder the requisite
number of shares of Common Stock to be issued pursuant to this Warrant. The Company shall at all
times reserve and keep available, solely for issuance and delivery as Warrant Shares hereunder,
such shares of Common Stock as shall from time to time be issuable as Warrant Shares.




          (d) From the date hereof through the last date on which this Warrant is exercisable, the
Company shall take all steps commercially reasonable to ensure that the Common Stock remains listed
or quoted on the Principal Market.




 









 








     Section 6. Adjustment of the Exercise Price. The Exercise Price and, accordingly, the
number of Warrant Shares issuable upon exercise of the Warrant, shall be subject to adjustment from
time to time upon the happening of certain events as follows:



          (a) Reclassification, Consolidation, Merger, Mandatory Share Exchange, Sale or
Transfer.




               (i) Upon occurrence of any of the events specified in subsection (a)(ii) below (the
“Adjustment Events”) while this Warrant is unexpired and not exercised in full, the Warrant
Holder may in its sole discretion require the Company, or any successor or purchasing corporation,
as the case may be, without payment of any additional consideration therefor, upon surrender by the
Warrant Holder of the Warrant to be replaced, to execute and deliver to the Warrant Holder a new
Warrant providing that the Warrant Holder shall have the right to exercise such new Warrant (upon
terms not less favorable to the Warrant Holder than those then applicable to this Warrant) and to
receive upon such exercise, in lieu of each share of Common Stock theretofore issuable upon
exercise of this Warrant, the kind and amount of shares of stock, other securities, money or
property receivable upon such Adjustment Event by the holder of one share of Common Stock issuable
upon exercise of this Warrant had this Warrant been exercised immediately prior to such Adjustment
Event. Such new Warrant shall provide for adjustments that shall be as nearly equivalent as may be
practicable to the adjustments provided for in this Section 6.



               (ii) The Adjustment Events shall be (1) any reclassification or change of Common Stock (other
than a change in par value, as a result of a subdivision or combination of Common Stock or in
connection with an Excluded Merger or Sale), (2) any consolidation, merger or mandatory share
exchange of the Company with or into another corporation (other than a merger or mandatory share
exchange with another corporation in which the Company is a continuing corporation and which does
not result in any reclassification or change other than a change in par value or as a result of a
subdivision or combination of Common Stock), other than (each of the following referred to as an
“Excluded Merger or Sale”) a transaction involving (A) sale of all or substantially all of
the assets of the Company, (B) any merger, consolidation or similar transaction where the
consideration payable to the shareholders of the Company by the acquiring Person consists
substantially of cash or publicly traded securities, or a combination thereof, or where the
acquiring Person does not agree to assume the obligations of the Company under outstanding warrants
(including this Warrant). In the event of an Excluded Merger or Sale, the Company shall deliver a
notice to the Warrant Holder at least 10 days before the consummation of such Excluded Merger or
Sale, the Warrant Holder may exercise this Warrant at any time before the consummation of such
Excluded Merger or Sale (and such exercise may be made contingent upon the consummation of such
Excluded Merger or Sale), and any portion of this Warrant that has not been exercised before
consummation of such Excluded Merger or Sale shall terminate and expire, and shall no longer be
outstanding.



          (b) Subdivision or Combination of Shares. If the Company, at any time while this
Warrant is unexpired and not exercised in full, shall subdivide its Common Stock, the Exercise
Price shall be proportionately reduced as of the effective date of such subdivision, or, if the
Company shall take a record of holders of its Common Stock for the purpose of so subdividing its
Common Stock, as of such record date, whichever is earlier. If the Company, at



 









 






any time while this Warrant is unexpired and not exercised in full, shall combine its Common
Stock, the Exercise Price shall be proportionately increased as of the effective date of such
combination, or, if the Company shall take a record of holders of its Common Stock for the purpose
of so combining its Common Stock, as of such record date, whichever is earlier.




          (c) Stock Dividends. If the Company, at any time while this Warrant is unexpired and
not exercised in full, shall pay a dividend or other distribution in shares of Common Stock to all
holders of Common Stock, then the Exercise Price shall be adjusted, as of the date the Company
shall take a record of the holders of its Common Stock for the purpose of receiving such dividend
or other distribution (or if no such record is taken, as at the date of such payment or other
distribution), to that price determined by multiplying the Exercise Price in effect immediately
prior to such payment or other distribution by a fraction: (i) the numerator of which shall be the
total number of shares of Common Stock outstanding immediately prior to such dividend or
distribution, and (ii) the denominator of which shall be the total number of shares of Common Stock
outstanding immediately after such dividend or distribution. The provisions of this subsection
(c) shall not apply under any of the circumstances for which an adjustment is provided in
subsections (a) or (b).




          (d) Liquidating Dividends, Etc. If the Company, at any time while this Warrant is
unexpired and not exercised in full, makes a distribution of its assets or evidences of
indebtedness to the holders of its Common Stock as a dividend in liquidation or by way of return of
capital or other than as a dividend payable out of earnings or surplus legally available for
dividends under applicable law or any distribution to such holders made in respect of the sale of
all or substantially all of the Company’s assets (other than under the circumstances provided for
in the foregoing subsections (a) through (c)), then the Warrant Holder shall be entitled to receive
upon exercise of this Warrant in addition to the Warrant Shares receivable in connection therewith,
and without payment of any consideration other than the Exercise Price, the kind and amount of such
distribution per share of Common Stock multiplied by the number of Warrant Shares that, on the
record date for such distribution, are issuable upon such exercise of the Warrant (with no further
adjustment being made following any event which causes a subsequent adjustment in the number of
Warrant Shares issuable), and an appropriate provision therefor shall be made a part of any such
distribution. The value of a distribution that is paid in other than cash shall be determined in
good faith by the Board of Directors of the Company. Notwithstanding the foregoing, in the event
of a proposed dividend in liquidation or distribution to the shareholders made in respect of the
sale of all or substantially all of the Company’s assets, the Company shall deliver a notice to the
Warrant Holder at least 10 days before the consummation of such event, the Warrant Holder may
exercise this Warrant at any time before the consummation of such event (and such exercise may be
made contingent upon the consummation of such event), and any portion of this Warrant that has not
been exercised before consummation of such event shall terminate and expire, and shall no longer be
outstanding.




          (e) Adjustment for Spin Off. If, for any reason, prior to the exercise of this
Warrant in full, the Company spins off or otherwise divests itself of a part of its business or
operations or disposes all or a part of its assets in a transaction (a “Spin Off”) in which
the Company does not receive compensation for such business, operations or assets, but causes
securities of another entity (“Spin Off Securities”) to be issued to all or substantially
all holders of Common Stock, then the Company shall cause (i) to be reserved Spin Off Securities
equal to



 









 






the number thereof which would have been issued to the Warrant Holder in the event that the
entire unexercised portion of this Warrant outstanding on the record date (the “Record
Date”) for determining the number of Spin Off Securities to be issued to holders of Common
Stock had been exercised by the Warrant Holder as of the close of business on the Trading Day
immediately prior to the Record Date (the “Reserved Spin Off Shares”), and (ii) to be
issued to the Warrant Holder on the exercise of all or any unexercised portion of this Warrant,
such amount of the Reserved Spin Off Shares equal to (x) the Reserved Spin Off Shares multiplied by
(y) a fraction, of which (I) the numerator is the unexercised portion of this Warrant then being
exercised, and (II) the denominator is the aggregate amount of the unexercised portion of this
Warrant.




     Section 7. Notice of Adjustments. Whenever the Exercise Price or number of Warrant
Shares shall be adjusted pursuant to Section 6 hereof, the Company shall promptly prepare a
certificate signed by its Chief Executive Officer or Chief Financial Officer setting forth in
reasonable detail the event requiring the adjustment, the amount of the adjustment, the method by
which such adjustment was calculated (including a description of the basis on which the Company’s
Board of Directors made any determination hereunder), and the Exercise Price and number of Warrant
Shares purchasable at that Exercise Price after giving effect to such adjustment, and shall
promptly cause copies of such certificate to be sent by overnight courier to the Warrant Holder.



     Section 8. No Impairment. The Company will not, by amendment of its Charter or Bylaws
or through any reorganization, transfer of assets, consolidation, merger, dissolution or issue or
sale of securities, avoid or seek to avoid the observance or performance of any of the terms of
this Warrant, but will at all times in good faith assist in the carrying out of all such terms and
in the taking of all such action as may be necessary or appropriate in order to protect the rights
of the Warrant Holder against impairment. Without limiting the generality of the foregoing, the
Company (a) will not increase the par value of any Warrant Shares above the amount payable therefor
on such exercise, and (b) will take all such action as may be reasonably necessary or appropriate
in order that the Company may validly and legally issue fully paid and non-assessable Warrant
Shares on the exercise of this Warrant. Notwithstanding the foregoing, nothing in this Section 8
shall restrict or impair the Company’s right to effect any changes to the rights, preferences,
privileges or restrictions associated with the Warrant Shares so long as such changes do no affect
the rights, preferences, privileges or restrictions associated with the Warrant Shares in a manner
adversely different from the effect that such changes have generally on the rights, preferences,
privileges or restrictions associated with all other shares of Common Stock.



     Section 9. Rights As Stockholder. Except as set forth in Section 6 above, prior to
exercise of this Warrant, the Warrant Holder shall not be entitled to any rights as a stockholder
of the Company with respect to the Warrant Shares, including (without limitation) the right to vote
such shares, receive dividends or other distributions thereon or be notified of stockholder
meetings.



     Section 10. Replacement of Warrant. Upon receipt of evidence reasonably satisfactory
to the Company of the loss, theft, destruction or mutilation of the Warrant and, in the case of any
such loss, theft or destruction of the Warrant, upon delivery of an indemnity agreement or security
reasonably satisfactory in form and amount to the Company or, in the case



 









 







of any such mutilation, on surrender and cancellation of such Warrant, the Company at its
expense will execute and deliver, in lieu thereof, a new Warrant of like tenor.



     Section 11. Choice of Law. This Warrant shall be construed under the laws of the
State of New York.



     Section 12. Entire Agreement; Amendments. Except for any written instrument
concurrent or subsequent to the date hereof executed by the Company and the Investor, this Warrant,
the Agreement and the Registration Rights Agreement contain the entire understanding of the parties
with respect to the matters covered hereby and thereby. No provision of this Warrant may be waived
or amended other than by a written instrument signed by the party against whom enforcement of any
such amendment or waiver is sought.



     Section 13. Restricted Securities.



          (a) Registration or Exemption Required. This Warrant has been issued in a transaction
exempt from the registration requirements of the Securities Act of 1933, as amended, in reliance
upon the provisions of Section 4(2) thereof and Regulation D promulgated thereunder, and/or upon
such other exemption from the registration requirements of the Securities Act as may be available
with respect to this Warrant. This Warrant and the Warrant Shares issuable upon exercise of this
Warrant may not be resold except pursuant to an effective registration statement or an exemption to
the registration requirements of the Securities Act of 1933 and applicable state laws.




          (b) Legend. Any replacement Warrants issued pursuant to Section 2 and Section 10
hereof and, unless a registration statement has been declared effective by the SEC in accordance
with the Securities Act with respect thereto, any Warrant Shares issued upon exercise hereof, shall
bear the following legend:





“THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE U.S.
SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY OTHER APPLICABLE
SECURITIES LAWS AND HAVE BEEN ISSUED IN RELIANCE UPON AN EXEMPTION FROM THE REGISTRATION
REQUIREMENTS OF THE SECURITIES ACT AND SUCH OTHER SECURITIES LAWS. NEITHER THIS SECURITY
NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED,
PLEDGED, ENCUMBERED, HYPOTHECATED OR OTHERWISE DISPOSED OF, EXCEPT PURSUANT TO AN EFFECTIVE
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR ANY OTHER APPLICABLE SECURITIES LAWS, OR
PURSUANT TO A TRANSACTION WHICH IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION.”



          (c) No Other Legend or Stock Transfer Restrictions. No legend other than the one
specified in Section 13(b) has been or shall be placed on the share certificates representing the
Warrant Shares and no instructions or “stop transfer orders” (so called “stock transfer
restrictions”) or other restrictions have been or shall be given to the Company’s transfer
agent with respect thereto other than as expressly set forth in this Section 13.




 









 








          (d) Assignment. Assuming the conditions of Section 13(a) above regarding registration
or exemption have been satisfied, the Warrant Holder may sell, transfer, assign, pledge or
otherwise dispose of this Warrant (each of the foregoing, a “Transfer”), in whole or in
part, but only to an Affiliate of the Warrant Holder. The Warrant Holder shall deliver a written
notice to Company, substantially in the form of the Assignment attached hereto as
Exhibit B, indicating the person or persons to whom the Warrant shall be Transferred and
the respective number of warrants to be Transferred to each assignee. The Company shall effect the
Transfer within ten (10) days, and shall deliver to the Transferee(s) designated by the Warrant
Holder a Warrant or Warrants of like tenor and terms for the appropriate number of shares. In
connection with and as a condition of any such proposed Transfer, the Company may require (i) the
Warrant Holder to provide an opinion of counsel to the Warrant Holder in form and substance
reasonably satisfactory to the Company to the effect that the proposed Transfer complies with all
applicable federal and state securities laws and (ii) any such Transferee to provide customary
representations and warranties attendant to the acquisition of unregistered securities, including
without limitation the Transferee’s investment intent and status as an “accredited investor” within
the meaning of Regulation D.




          (e) Investor’s Compliance. Nothing in this Section 13 shall affect in any way the
Investor’s obligations under any agreement to comply with all applicable securities laws upon
resale of the Common Stock.




     Section 14. Notices. All notices, demands, requests, consents, approvals, and other
communications required or permitted hereunder shall be given in accordance with Section 10.4 of
the Agreement.



     Section 15. Miscellaneous. This Warrant and any term hereof may be changed, waived,
discharged or terminated only by an instrument in writing signed by the party against which
enforcement of such change, waiver, discharge or termination is sought. The headings in this
Warrant are for purposes of reference only, and shall not limit or otherwise affect any of the
terms hereof. The invalidity or unenforceability of any provision hereof shall in no way affect
the validity or enforceability of any other provision.



     Section 16. Company Call Right.



          (a) If a Funding Default occurs, the Company shall have the right to demand the surrender of
this Warrant or any remaining portion thereof, Warrant Shares and/or cash from the Investor as
follows (the “Call Right”):




               (i) If the Investor has not previously exercised this Warrant in full, then the Company shall
have a right to demand the surrender of this Warrant, or remaining portion thereof, from the
Investor without compensation, and the Investor shall promptly surrender this Warrant, or remaining
portion thereof. Following such demand for surrender, this Warrant shall automatically be deemed
to have been canceled and shall have no further force or effect.



               (ii) If, prior to receiving a Call Right Notice (as defined below), the Investor has
previously exercised this Warrant with respect to some or all of the Warrant Shares,



 









 







and the Investor has not previously sold such Warrant Shares, then Company shall have a right
to purchase from the Investor that number of shares of Common Stock equal to the number of shares
of Common Stock issued in connection with the exercise(s) of the Warrant, at a repurchase price per
share equal to the price per share paid by the Investor in connection with such exercise(s). For
greater certainty, (a) if Warrant Shares were exercised for cash, the purchase price per share
under the Call Right shall be equal to the Exercise Price, (b) if Warrant Shares were exercised on
a cashless exercise basis, the purchase price per share for such Warrant Shares under the Call
Right shall be zero, and (c) if such Warrant Shares were exercised on both a cash and cashless
exercise basis, the purchase price per share under the Call Right shall be equal to the total
amount of cash paid in connection with such cash exercise(s) divided by the total number of shares
of Common Stock issued in connection with all exercises of the Warrant (whether on a cash or
cashless basis).



               (iii) If, prior to receiving a Call Right Notice, the Investor has previously exercised this
Warrant with respect to some or all of the Warrant Shares, and the Investor subsequently sold such
Warrant Shares, then the Investor shall remit to the Company the excess, if any, of (x) the
proceeds received by Investor through the sale of such Warrant Shares, over (y) the aggregate
Exercise Price for such Warrant Shares. In the event that the Investor obtained such Warrant
Shares through a Cashless Exercise, then the Investor shall instead remit to the Company all
proceeds received by the Investor through the sale of such Warrant Shares. For the avoidance of
doubt, in the event that the Investor has sold some or all of the Warrant Shares prior to receiving
a Call Right Notice, then the right set forth in this paragraph (iii) shall constitute the sole
Call Right of the Company with respect to such Warrant Shares which have been sold.



          (b) Company may exercise the Call Right by delivering a notice (the “Call Right
Notice”) to Investor within thirty (30) days after the occurrence of a Funding Default. On the
tenth (10th) business day following delivery of the Call Right Notice to Investor, Company shall
tender the purchase price, if any, and Investor shall tender shares of Common Stock, if any, to be
sold to Company pursuant to the Call Right Notice, immediately following which Company and Investor
shall consummate such purchase and sale. The Call Right shall survive both the assignment of the
Warrant by the Investor and the disposition of the Warrant Shares by the Investor following
exercise of the Warrant.




[Remainder of Page Intentionally Left Blank. Signature Page Follows.]




 









 




 EXECUTION
VERSION

     IN WITNESS WHEREOF, this Warrant was duly executed by the undersigned, thereunto duly
authorized, as of the date first set forth above.



	 	 	 	 	 
	 	 	EPIX PHARMACEUTICALS, INC.
	 
	 	 	 	 
	 

	 	By:
	 	/s/ Kim Cobleigh Drapkin
	 

	 	 	 	 
	 

	 	 	 	Kim Cobleigh Drapkin
	 

	 	 	 	Chief Financial Officer






     Investor acknowledges and agrees to the terms and conditions of this Warrant.



	 	 	 	 	 
	 	 	KINGSBRIDGE CAPITAL LIMITED
	 
	 	 	 	 
	 

	 	By:
	 	/s/ Antony Gardner-Hillman
	 

	 	 	 	 
	 

	 	 	 	Antony Gardner-Hillman
	 

	 	 	 	Director






[Signature Page to Warrant to Purchase Common Stock]




 









 








EXHIBIT A TO THE WARRANT




EXERCISE FORM




EPIX PHARMACEUTICALS, INC.




     The
undersigned hereby irrevocably exercises the right to purchase
                     shares of
Common Stock of EPIX Pharmaceuticals, Inc., a Delaware corporation (the “Company”),
evidenced by the attached Warrant, and, subject to the Company’s rights set forth in Section 2(c)
of the Warrant, (CIRCLE EITHER (i) or (ii)) (i) tenders herewith payment of the Aggregate Exercise
Price with respect to such shares in full, in the amount of $                    , in cash, by certified or
official bank check or by wire transfer for the account of the Company or (ii) elects, pursuant to
Section 2(c) of the Warrant, to convert such Warrant into shares of Common Stock of the Company on
a cashless exercise basis, all in accordance with the conditions and provisions of said Warrant.



     The undersigned requests that stock certificates for such Warrant Shares be issued, and a
Warrant representing any unexercised portion hereof be issued, pursuant to this Warrant, in the
name of the registered Warrant Holder and delivered to the undersigned at the address set forth
below.



	 	 	 	 	 
	Dated:
	 	 	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	 	 	 
	Signature of Registered Holder	 	 
	 
	 	 	 	 
	 	 	 
	Name of Registered Holder (Print)	 	 
	 
	 	 	 	 
	 	 	 
	Address	 	 






 









 






EXHIBIT B TO THE WARRANT




ASSIGNMENT




     (To be executed by the registered Warrant Holder desiring to transfer the Warrant)



     FOR VALUED RECEIVED, the undersigned Warrant Holder of the attached Warrant hereby sells,
assigns and transfers unto the persons below named the right to
purchase                      shares of
Common Stock of EPIX Pharmaceuticals, Inc., A Delaware corporation (the “Company”)
evidenced by the attached Warrant and does hereby irrevocably constitute and appoint
                     attorney to transfer the said Warrant on the books of the Company, with full power
of substitution in the premises.



	 	 	 	 	 
	Dated:
	 	 	 	 
	 

	 	 

	 	 
	 
	 	 	 	 
	 	 	 
	Signature	 	 
	 
	 	 	 	 
	Fill in for new Registration of Warrant:
	 
	 	 	 	 
	 	 	 
	Name
	 	 	 	 
	 
	 	 	 	 
	 	 	 
	Address
	 	 	 	 
	 
	 	 	 	 
	 	 	 
	Please print name and address of assignee (including zip code number)