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                                                                     EXHIBIT 3.1

                               State of Delaware
                             AMENDED AND RESTATED
                         CERTIFICATE OF INCORPORATION
                                      OF
                        KERYX BIOPHARMACEUTICALS, INC.


     KERYX BIOPHARMACEUTICALS, INC., a corporation organized and existing under
the laws of the State of Delaware, hereby certifies as follows:

          1.   The Certificate of Incorporation for KERYX BIOPHARMACEUTICALS,
INC. was filed in the Office of the Secretary of State of Delaware on October
22, 1998.

          2.   Pursuant to Sections 242 and 245 of the General Corporation Law
of the State of Delaware, this Amended and Restated Certificate of Incorporation
amends, restates and integrates the Certificate of Incorporation of this
corporation.

          3.   The text of the Certificate of Incorporation as amended or
supplemented heretofore is hereby restated and further amended to read in its
entirety as follows:

                               State of Delaware
                             AMENDED AND RESTATED
                         CERTIFICATE OF INCORPORATION
                              A Stock Corporation

 .    First:  The name of this corporation is KERYX BIOPHARMACEUTICALS, INC.

 .    Second: Its registered office in the State of Delaware is located at 1013
     Centre Road, City of Wilmington 19805, County of Now Castle; and the name
     of the registered agent of the corporation in the State of Delaware at such
     address is Corporation Service Company.

 .    Third:  The purpose of the corporation is to engage in any lawful act or
     activity for which corporations may be organized under the General
     Corporation Law of the State of Delaware.

 .    Fourth: The total number of shares of stock which the corporation shall
     have the authority to issue is 40,000,000 shares of Common Stock with a par
     value of $ 0.001 per share and 5,000,000 shares of Common Stock, par value
     $0.001 per share.
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 .    Fifth:  The name and mailing address of the incorporator are as follows:

                    John S. Hoenigmann
                    Two World Trade Center
                    Suite 8746
                    New York, New York 10048

 .    Sixth: The corporation is to have perpetual existence.

 .    Seventh:  Wehnever a compromise or arrangement is proposed between this
     corporation and its creditors or any class of them and/or between this
     corporation and its stockholders or any class of them, any court of
     equitable jurisdiction within the State of Delaware may, on the application
     in a summary way of this corporation or of any creditor or stockholder
     thereof or on the application of any receiver or receivers appointed for
     this corporation under section 291 of Title 8 of the Delaware Code or ont
     hte application of trustees in dissolution or of any receiver or receivers
     appointed for this corporation under section 279 of Title 8 of the Delaware
     Code order a meeting of the creditors or class of creditors, and/or of the
     stockholders or class of stockholders of this corporation, as the case may
     be, to be summoned in such manner as the said court directs.  If a majority
     in number representing three fourths in value of the creditors or class of
     creditors, and/or of the stockholders or class of stockholders of htis
     corporation, as the case may be, agree to any compromise or arrangement,
     and to any reorganization of this corporation as consequence of such
     compromise or arrangement, the said compromise or arrangement and the said
     reorganization shall, if sanctioned by the court to which the said
     application has been made, be binding on all the creditors or class or
     creditors, and/or on all the stockholders or class of stockholders, of this
     corporation, as the case may be, and also on this corporation.

 .    Eighth: For the managment of the business and for the conduct of the
     affairs of the corporation, and in further definition, limitation, and
     regulation of the powers of the corporation and of its directors and of its
     stockholders or any class thereof, as the case may be, it is further
     provided:

          1.  The managment of the business and hte conduct of the affairs of
the corporation shall be vested in its Board of Directors.  The number of
directors which shall constitute the whole Board of Directors shall be fixed by,
or in the manner provided in, the Bylaws.  The phrase "whole Board" and the
phrase "total number of directors" shall be deemed to have the same meaning, to
wit, the total number of directors which the corporation would have if there
were no vacancies.  No election of directors need be by written ballot.

          2.  After the original or other Bylaws of the corporation have been
adopted, amended, or repealed, as the case may be, in accordance with the
provisions of section 109 of the General Corporation Law of the the State of
Delaware, and, after the corporation has received any payments for any of its
stock, the power to adopt, amend, or repeal the Bylaws of the
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corporation may be exercised by the Board of Directors of the corporation;
provided, however, that any provision for the classification of directors of the
corporation for staggered terms pursuant to the provisions of subsection (d) of
section 141 of the General Corporation Law of the State of Delaware shall be set
forth in an initial Bylaw or in a Bylaw adopted by the stockholders entitled to
vote of the corporation unless provisions for such classification shall be set
forth inthe certificate of incorporation.

          3.  Whenever the corporation shall be authorized to issue only one
class of stock, each outstanding share shall entitle the holder thereof to
notice of, and the right to vote at, any meeting of stockholders.  Whenever the
corporation shall be authorized to issue more than one class of stock, no
outstanding shares of any class of stock which is denied voting power under the
provisions of the certificate of incorporation shall entitle the holder thereof
to the right to vote at any meeting of stockholders except as the provisions of
paragraph (2) of subsection (b) of section 242 of the General Corporation Law of
the State of Delaware shall otherwise require; provided, that no share of any
such class which is otherwise denied voting power shall entitle the holder
thereof to vote upon the increase or decrease in the number of authorized shares
of said class.

 .    Ninth:  The personal liability of the directors of the corporatioin is
     hereby eliminated to the fullest extent permitted by the provisions of
     paragraph (7) of subsection (b) of section 102 of the General Corporation
     Law of the State of Delaware, as the same may be amended and supplemented.

 .    Tenth:  The corporation shall, to the fullest extend permitted by the
     provisions of section 145 of the General Corporation Law of the State of
     Delaware, as the same may be amended and supplemented, indemnify any and
     all persons whom it shall have power to indemnity under said section from
     and agains any and all of the expenses, liabilities, or other realtors
     referred to in or covered by said section, and the indemnification provided
     for herein shall not be deemed exclusive of any other rights to which those
     indemnified may be entitled under and Bylaw, agreement, vote of
     stockholders or disintegrated directors or otherwise, both as to action in
     such person's official capacity and as to action in another capacity while
     holding such office, and shall continue as to a person who has ceased to be
     a director, officer, employee, or agent and shall inure to the benefit of
     the heirs, executors, adn administrators of such person.

 .    Eleventh:  From time to time any of the provisions of this certificate of
     incorporation may be amended, altered, or repaired, and other provisions
     authorized by the laws of the State of Delaware at the time in force may be
     added or inserted in the manner and at the time prescribed by said laws,
     and all rights at any time conferred upon the stockholders of the
     corporation by this certificate of incorporation are granted subject to the
     provisions of this Article Eleventh.