Exhibit 3.1

                            Certificate of Amendment
                                       Of
                Amended and Restated Certificate of Incorporation
                                       of
                         keryx biopharmaceuticals, inc.
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        Keryx Biopharmaceuticals, Inc., a corporation organized and existing
under and by virtue of the Delaware General Corporation Law (the "Corporation"),
does hereby certify:

        FIRST: That on April 14, 2004, the Board of Directors of the Corporation
        adopted resolutions setting forth a proposed amendment to the Amended
        and Restated Certificate of Incorporation of the Corporation and
        declaring its advisability. The proposed amendment is as follows:

                  RESOLVED, that the Corporation's Amended and Restated
                  Certificate of Incorporation be amended by deleting Article
                  FOURTH in its entirety and by substituting in lieu thereof the
                  following:

                           "FOURTH: The total number of shares of all classes of
                           stock which the Corporation shall have the authority
                           to issue is 65,000,000, which is divided into
                           60,000,000 shares of Common Stock, par value $0.001
                           per share, and 5,000,000 shares of Preferred Stock,
                           par value $0.001 per share."

        SECOND: That said amendment was duly adopted in accordance with the
        provisions of Section 242 of the Delaware General Corporate Law.


         IN WITNESS WHEREOF, the Corporation has caused this certificate to be
signed by a duly authorized officer this 18th day of June, 2004.




                                      By: /s/ Michael S. Weiss
                                          -------------------------------------
                                          Michael S. Weiss
                                          Chairman and Chief Executive Officer

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                              AMENDED AND RESTATED
                          CERTIFICATE OF INCORPORATION
                                       OF
                         KERYX BIOPHARMACEUTICALS, INC.


FIRST: The name of the corporation (hereinafter called the "Corporation") is
KERYX BIOPHARMACEUTICALS, INC.

SECOND: Its registered office in the State of Delaware is located at 2711
Centerville Road, Suite 400, City of Wilmington 19808, County of New Castle; and
the name of the registered agent of the Corporation in the State of Delaware at
such address is Corporation Service Company.

THIRD: The purpose of the Corporation is to engage in any lawful act or activity
for which corporations may be organized under the General Corporation Law of the
State of Delaware, as from time to time amended (the "DGCL").

FOURTH: The total number of shares of all classes of stock which the Corporation
shall have the authority to issue is 45,000,000, which is divided into
40,000,000 shares of Common Stock, par value of $0.001 per share, and 5,000,000
shares of Preferred Stock, par value $0.001 per share.

FIFTH: The Corporation is to have perpetual existence.

SIXTH: Whenever a compromise or arrangement is proposed between the Corporation
and its creditors or any class of them and/or between the Corporation and its
stockholders or any class of them, any court of equitable jurisdiction within
the State of Delaware may, on the application of the Corporation or of any
creditor or stockholder thereof or on the application of any receiver or
receivers appointed for the Corporation under Section 291 of Title 8 of the DGCL
or on the application of trustees in dissolution or of any receiver or receivers
appointed for the Corporation under Section 279 of Title 8 of the DGCL, order a
meeting of the creditors or class of creditors, and/or of the stockholders or
class of stockholders of the Corporation, as the case may be, to be summoned in
such manner as the said court directs. If a majority in number representing
three-fourths in value of the creditors or class of creditors, and/or of the
stockholders or class of stockholders of the Corporation, as the case may be,
agrees to any compromise or arrangement, and to any reorganization of the
Corporation as a consequence of such compromise or arrangement, the said
compromise or arrangement and the said reorganization shall, if sanctioned by
the court to which the said application has been made, be binding on all the
creditors or class of creditors, and/or on all the stockholders or class of
stockholders, of the Corporation, as the case may be, and also on the
Corporation.

SEVENTH: For the management of the business and for the conduct of the affairs
of the Corporation, and in further definition, limitation, and regulation of the
powers of the Corporation and of its directors and of its stockholders or any
class thereof, as the case may be, it is further provided:


<PAGE>

        1. The management of the business and the conduct of the affairs of the
Corporation shall be vested in its Board of Directors. The number of directors
which shall constitute the whole Board of Directors shall be fixed by, or in the
manner provided in, the Bylaws. The phrase "whole Board" and the phrase "total
number of directors" shall be deemed to have the same meaning, to wit, the total
number of directors which the Corporation would have if there were no vacancies.
No election of directors need be by written ballot.

        2. After the original or other Bylaws of the Corporation have been
adopted, amended, or repealed, as the case may be, in accordance with the
provisions of Section 109 of the DGCL, and, after the Corporation has received
any payments for any of its stock, the power to adopt, amend, or repeal the
Bylaws of the Corporation may be exercised by the Board of Directors of the
Corporation; provided, however, that any provision for the classification of
directors of the Corporation for staggered terms pursuant to the provisions of
subsection (d) of Section 141 of the DGCL shall be set forth in an initial Bylaw
or in a Bylaw adopted by the stockholders entitled to vote of the Corporation
unless provisions for such classification shall be set forth in the certificate
of incorporation.

        3. Whenever the Corporation shall be authorized to issue only one class
of stock, each outstanding share shall entitle the holder thereof to notice of,
and the right to vote at, any meeting of stockholders. Whenever the Corporation
shall be authorized to issue more than one class of stock, no outstanding shares
of any class of stock which is denied voting power under the provisions of the
certificate of incorporation shall entitle the holder thereof to the right to
vote at any meeting of stockholders except as the provisions of paragraph (2) of
subsection (b) of Section 242 of the DGCL shall otherwise require; provided,
that no share of any such class which is otherwise denied voting power shall
entitle the holder thereof to vote upon the increase or decrease in the number
of authorized shares of said class.

EIGHTH: The personal liability of the directors of the Corporation is hereby
eliminated to the fullest extent permitted by the provisions of paragraph (7) of
subsection (b) of Section 102 of the DGCL, as the same may be amended and
supplemented.

NINTH: The Corporation, to the fullest extent permitted by the provisions of
Section 145 of the DGCL, as the same may be amended and supplemented, shall
indemnify any and all persons whom it shall have power to indemnity under said
section from and against any and all of the expenses, liabilities, or other
matters referred to in or covered by said section, and the indemnification
provided for herein shall not be deemed exclusive of any other rights to which
those indemnified may be entitled under any Bylaw, agreement, vote of
stockholders or disinterested directors or otherwise, both as to action in such
person's official capacity and as to action in another capacity while holding
such office, and shall continue as to a person who has ceased to be a director,
officer, employee, or agent and shall inure to the benefit of the heirs,
executors, and administrators of such person.

TENTH: From time to time any of the provisions of this certificate of
incorporation may be amended, altered, or repealed, and other provisions
authorized by the laws of the State of Delaware at the time in force may be
added or inserted in the manner and at the time prescribed by said laws, and all
rights at any time conferred upon the stockholders of the corporation by this
certificate of incorporation are granted subject to the provisions of this
Article TENTH.