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|   |   |                                                                                                                                                          |
|--------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------|
| x      |   | ANNUAL REPORT PURSUANT TO      SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF      1934                                                           |
|   |   | For the fiscal year ended      December 31, 2008                                                                                                              |
| OR     |
| o      |   | TRANSITION REPORT PURSUANT TO      SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF      1934                                                       |
|   |   | For the transition period      from          to           |

|                                                                     |   |                                           |
|--------------------------------------------------------------------------|--------|------------------------------------------------|
| Delaware                                                                 |   | 11-3516358                                     |
| (State      or other jurisdiction of incorporation or      organization) |   | (I.R.S.      Employer Identification      No.) |
|                                                                     |   |                                           |
| 9620      Medical Center DriveRockville,      Maryland                   |   | 20850                                          |
| (Address of principal      executive offices)                            |   | (Zip      Code)                                |

|                                               |   |                                           |
|----------------------------------------------------|--------|------------------------------------------------|
| Title of Each      Class                           |   | Name of Each Exchange on Which      Registered |
| Common Stock, $.0001 par      value per share |   | NYSE      Alternext US                         |

|                           |                                |                                               |                                  |
|--------------------------------|-------------------------------------|----------------------------------------------------|---------------------------------------|
| Large      accelerated filer o | Accelerated      filer  x | Non-accelerated      filer o                  | Smaller      reporting company x |
|                           |                                | (Do      not check if a smaller reporting company) |                                  |

|                                               |   |                               |
|----------------------------------------------------|--------|------------------------------------|
| Class                                              |   | Outstanding at March 16,      2009 |
|                                               |   |                               |
| Common      Stock, $.0001 par value per share |   | 56,025,649 shares             |
|                                               |   |                               |

|     |   |                               |
|----------|--------|------------------------------------|
| Document |   | Parts Into Which      Incorporated |
|     |   |                               |
| None.    |   | -                                  |

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|                            |                              |                           |   |   |
|---------------------------------|-----------------------------------|--------------------------------|--------|--------|
|                            | REXAHN      PHARMACEUTICALS, INC. |                           |
|                            |                              |                           |
| Date:      March 24, 2009  | By:                | /s/      Tae Heum Jeong   |   |
|                            |                              | Tae      Heum Jeong       |   |
|                            |                              | Chief      Financial Officer   |   |

| Name                                                                           | Title                                                |
|--------------------------------------------------------------------------------|------------------------------------------------------|
| /s/ Chang H. Ahn*          Chang      H. Ahn               | Chairman      and Chief Executive Officer            |
| /s/ Tae Heum Jeong*          Tae      Heum Jeong           | Chief      Financial Officer, Secretary and Director |
| /s/ Freddie Ann      Hoffman*     Freddie      Ann Hoffman | Director                                             |
| /s/ David McIntosh*          David      McIntosh           | Director                                             |
| /s/ Charles Beever*          Charles      Beever           | Director                                             |
| /s/ Kwang Soo Cheong*    Kwang      Soo Cheong             | Director                                             |
| /s/ Y. Michele      Kang*     Y.      Michele Kang         | Director                                             |

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|    |   |                                                                                                                                                                |
|---------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Exhibit |   |                                                                                                                                                                |
| Number  |   | Description      of Exhibit                                                                                                                                         |
|    |   |                                                                                                                                                                |
| 23.1    |   | Consent      of Parente Randolph, LLC                                                                                                                               |
| 23.2    |   | Consent      of Lazar, Levine & Felix LLP                                                                                                                       |
| 24      |   | Power      of Attorney filed as Exhibit 24 to the Company’s Annual Report on Form      10-K filed on March 16, 2009 is hereby incorporated by      reference. |
| 31.1    |   | Certification      of Chief Executive Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under      the Securities Exchange Act of 1934, as amended.                 |
| 31.2    |   | Certification      of Chief Financial Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under      the Securities Exchange Act of 1934, asamended.                  |

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