# **Exhibit 32.1**

# ** **

## **CERTIFICATE PURSUANT TO 18 U.S.C.SECTION 1350,**

## ** AS ADOPTED PURSUANT TO SECTION 906 OF THE**

## **SARBANES-OXLEY ACT OF 2002**

 
| In connection  with the Quarterly Report of GlobalSCAPE, Inc. on Form 10-Q for the period  ending September 30, 2007 as filed with the Securities and Exchange  Commission on the date hereof (the “Report”), we, Charles R. Poole, President  and Chief Executive Officer, and Bernard N. Schneider, Chief Financial  Officer, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to  Section 906 of the Sarbanes-Oxley Act of 2002, that: |
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                |
| (1)                                                                                                                                                                                                                                                                                                                                                                                                                                                                 | The Report fully  complies with the requirements of section 13(a) or 15(d) of the Securities  Exchange Act of 1934; and |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |
| (2)                                                                                                                                                                                                                                                                                                                                                                                                                                                                 | The information  contained in the Report fairly presents, in all material respects, the  financial condition and results of operations of GlobalSCAPE, Inc. |

 

 
| /s/ Charles R. Poole                   |   |
|----------------------------------------|--------|
| Charles R. Poole                       |
| President and Chief  Executive Officer |
| November 14, 2007                      |
|                                   |
|                                   |
| /s/ Kelly E. Simmons                   |   |
| Kelly E. Simmons                       |
| Chief Financial Officer                |
| November 14, 2007                      |

 

# ****