# F o

ilUNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON , D.C. 20460 OFF I CE OF C HEMI C AL SAFET Y A ND POL L UT I ON PRE V ENT IO N



### MEMORAND UM D a t e : July9,2015 

### SU BJ EC T : Ferbarn: Tier I (Scop ing) Review of Human I nc idents and Epidem io logy

PC Co d e : 03480 I. 034804 Decis io n ' o.: 506261 Pet i tion No. : A Ri
.

sk Assessmen t Type: A T XR No.: NA MRID No.: NA DP B a r co cl e: 0427982 R egis t ra t io n No.: NA Reg ul ato r y Actio n : A Case No.: A CAS No.: 1448 · 1-64- 1 , 128- 04 -1 40 C FR : NA Ver.Apr.OS F ROM : Shanna Recore, Industrial Hygienist

### ~ I
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### ~ Toxicology and Epidem iology Branch**~** .**~** _./"**~d** ' Health Effect Division (7509 P)

### {VV'**~** E l izabeth Evans, E n v i ro n men tal P rotect ion Spec i alist 

# CJ,; Toxicology and Epidemiology Branch Health Effects Division (7509P) T HRO UG H: David Miller , Acting B ranch Chief Tox ico logy and Epidemio logy Branch Hea lth Effects Div i s io n (7509P) 

### TO : Jess ica Kidwell, Risk Assessor Risk Assessment Branch I V Health Effects Division (7509P) and J

. Parker , C h em ical R ev iew Manager Risk Manag e men t 

### & Implementat ion Branch I Pesticide Re-evaluation Divi s ion (750 8P) Summary a nd Conclusions Based on the low frequency a n d severity of in c ide n t cases r epor te d fo r fe rba m to both I D S and SENSOR-Pestic ides, there does not appear to be a concern at this t i me tha t would warrant furth e r investigation. The Agency wi ll continue to m on itor the incid e nt information and if a concern i s triggered , addi ti o nal ana lysis wi ll be inc l uded in the risk assessment.

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### I. A CTIO N REQ UE ST E D Thi s rev ie w i s in te nd e d to fulfill o ur re quire m e nt to d ocke t s umm a ri es of in c i d e nt d a ta th a t w ere repo rt e d t o th e Age n cy , as w e ll as t o e n s ure human inc iden t d at a an d th e Ag ri c ultu ral H ea lth Stud y ( AH S) a re pa r t o f the prob lem fo rm ul ati o n pha se of regi s tr a t ion r ev ie w . Re p o rt s o f a d ve r se he alth e ff e ct s a lle ge dl y d ue to a s p ec ifi c p e sti c id e e x p os ur e ( i.e. , an " in c id e nt ") a r e large ly se l f -r

epo rt e d a nd th e refore , ge n era ll y speakin g , ne ith e r expos ure to a pes ti c id e or repo rte d sy m ptom ( o r th e connection b e twe e n th e tw o) i s v alida te d or o th e r w i se c o nfirm e d
. T y pi ca ll y , ca u sati o n ca nn o t b e d e te rmin e d ba se d o n i nc id e nt d a t a . H o weve r , in c id e nt in fo rm a ti o n ca n be a n imp o rt a nt so urce o f feedbac k to th e Age n cy : in c ide nt s of seve re o ut co m e , or a s u gge s te d patte rn o r tre n d am o n g less sev e re in c i d e nt s, can s ig n a l th e A g en cy to furth e r in ves ti ga te a pa rt ic ul a r c hemi ca l o r prod u ct. O bse r v ati o n a l epid e mi o lo gy s tudi es r e la t e th e ri s k o f di sease , 

### e.g. , can ce r , a nd ex p os ure to a n a ge nt s u c h as a p es t ic ide prod uct in the ge n e ra l popu lat io n o r s pec i fi c s ub

- g ro u p s li ke pe s ticid e appl icat o rs . 

### II. BA C K G RO UN D F erba m ( dim e th y ldithi ocarba m a te sa lt s) i s a c a rba m a te f un g ic ide reg i s te re d fo r use o n c itru s , p o m e and s to n e fr uit s , c ranb e rr ies, an d tobacco. 1 Fo r thi s eva lu a ti o n , both the O P P In c ide n t D a ta Sys te m (IDS ) a n d the Ce nt e r s fo r D i sease C o ntro l and Preve nti on/N ati o n a l In s ti tut e for Occ upati o n a l Safe ty and H ea lth (C D C/N I OS H ) S e nt i ne l Eve nt Not i fi catio n Sys t e m fo r Occupa ti onal R i s k -P e s ti c ides ( SENS OR ) datab ases w e r e cons ulte d fo r pes ti c ide incid e nt data o n th e ac ti ve in g r e di e nt fe rb a m ( p c co d es: 0 34 801 , 034 8 0 4 )
. T h e p urpo se o f the d a t ab as e sea r c h is to identi fy p o t e nti a l p atte rn s in th e fre qu e n cy and severity of th e he a lth e ff e ct s a tt r i b u ted to f e rb am expo s ure. F e rb am i s n o t includ e d in the A HS , a nd the refo re th i s s tud y does n o t prov id e in fo rm a ti o n fo r thi s re po1t
. 

### III. RE SULT S/ DIS CUS SION

a. ID S (Incident Data Sys tem) OPP ' s ID S in cl ude s repo rt s o f a ll ege d human hea lth in c id e nt s fr o m vari o u s so urces , includin g man da to ry Fe d e ral In s e c ti c id e, F un g ic ide and R ode nt ic ide Ac t ( FI F RA ) Sec ti o n 6(a)(2) reports fr o m reg i stra nt s, ot h e r f e dera l a nd s ta t e heal th and e n viro nme nt a l a ge n c ies, and indi v id u a l co n s um e r s . Si nce 1 992, O PP h as co m p il e d these rep o rt s in ID S. ID S co n ta in s repo rt s fro m a cross the U
. S
. and m os t incid e nt s h ave a ll r e levant prod u c t in fo rma ti o n reco rd ed. Re p o rt s s ubmitte d to the I D S re pre s e nt an ecdo ta l repo rt s o r all egat io n s o nl y , u nl ess oth e rwi se s ta t e d i n th e repo rt. ID S re co r d s i ncid e nt s in o n e o f two m odules: M a i n I D S and A gg reg ate I D S:

1 http : //w w w.epa.gov/ pe s tici d es / rere g is tr atio n/ RE D s/ fact s hee t s / fc rba m _fac t
. pd f
P age 2o f4o M a in ID S conta in s incid e nts re s ulting in hi gher severity outcomes and pro v ides m o re det a il with regard t o case s pecific s . Thi s sys te m sto r es incident data fo r de at h , major and mod era te incidents , and it in c lude s inform a tion about th e location , date and nature of the incident. Main ID S incident s in vo l ving only one acti ve ingredient (as opposed to pesticid e products with multipl e active in g red ie nt s) are co nsid ered to provide more c e rt ain infom1 ation about the p o te ntial e ffects of exposure from the pesticide.



### o Agg re gate IDS contains incident s resulting in less severe human incident s ( minor , unknown , or no e ffects o u tcomes)
. T h ese are re ported by registrant s only as counts in w hat are agg r ega te s ummarie s . For the Main ID S, from January 

### I , 20 I 0 to February 

### 5 , 2 015 , there we re no incid e nt s reported in vo lv ing fe rbam. In Agg regate JD S , from Januar y I , 

### 20 I 

### 0 to February 

### 5 , 2015, there were no incidents reported involv in g ferbam. 

### b
. SENS OR -Pes ti c id es Th e SENSOR -P esticides database cov e r s 

### 12 s tates fr o m 

### 1998-2011 , alt hou g h reporting varies from state t o state. Cases of pesticide-related i ll n esses are asce rtained from a variety of sources , in c ludin g: re port s from loca l P o i so n Co ntrol Ce nt ers , s t ate D e partment of Labor wo rk ers' compensa ti o n claims w h e n rep o rt e d by physicians, r epo rts from State Dep a rtment s of Agriculture, and physic i an report s to s ta te D epartments of He a lth. Alt h ough both occupational a nd n o n- occ upati o n a l in c idents a re included in the dat a base , SENSOR- Pe st i c id es foc use s o n occupational pest icide incident s, a nd is of particular value in providing that inform a tion. The s t ate coord inator a t eac h o f the 

### 12 re spec ti ve s ta te D epartment s o f Health co nduct s case followup ac tiviti es s u c h as ob ta inin g me dical r eco rd s to verify symptoms a nd severity. Us ing s tandardi ze d protocol and case d e finitions derived from poi so n cente r reporting, the s tate SENSO R-P es ti c id e coordinator e nters the incid e nt in formation into the stat e -based sys tem w hi ch i s se nt to N IOSH annually to be aggregated. A r ev iew of SENSO R

- P es ticide s 

### 1998- 2 011 id e ntifi es 

### 19 ca ses, stemming from 

### 1 5 events , in vo lvin g fcrbam. Of these, nin e cases are s in g le ai , one case was a se lf-h arm attempt b y in gest i o n and ha s been re mo ve d from this analysis. Of the eight rem a inin g s ingle a i cases , four cases were mod e ra te in se verity a nd fo ur case s were low in seve rit y. The moderate an d l ow seve rit y cases ar e s umm a ri zed i n Tabl e 

### I belo w. SENS OR-Pestic id es 1998-20 11 S in 2 le Al Fe r ba m Case D esc r ip t io n Case ID Yea r Severi ty Case D esc rip tio n TX00999 1999 modera te Sprayi n g ter mit e s pray in enc losed area. Inhaled fumes a nd began developing sy mpt o m s. FL03920 20 10 modcra1e Ca ll e r s1a 1 es th at she was ex po sed t o so dium dimethyldithiocarbamate. It got into her boot and now her t oes are red.

P age 3of4FL03052 2008 moderate Wa s spraying unknown type of "d u st" (w/ ac ti ve in gredient Carbamatc 22%) two days ago. FL00502 1998 moderate Pati e nt sp l ashed product on his f ee t , hand s and groin a rea. Now he ha s blisters, was advised Lo remove contaminated clothe s. OR00913 2003 low No detail provided OR00905 2003 lo w No detai l provided NY00765 2003 low Man 2 days po st exposure to Raid insecticide
. SOB resolved but headache & blurry v is ion con tinu e. FLO l 240 2003 low Set off an unknown brand of fogger , did not leave the home for approx . 45 minutes later.

c . Ag ri c ultur a l H ea lth Stud y (A H S) 

### The AHS is a hi g h qua li ty, pro s pective ep id emiology study eval uating the link between pesticide use and vari o u s health outcomes in c ludin g cancer. The A HS includes private and commercia l pesticide app li cators and their spo us es. If 

### the re are AHS fi ndin gs re levant to a particular pesticide goi n g through reg istra tion review , th e Agency w ill ensure th ey are conside red in th e prob lem formu lation/scoping phase of the process and , if appropriate , fully rev iew ed in the risk assessme nt phase of the proces s. The AH S in c lud es information on us e of 80 different pesticide ac tive ingredient s commonly u se d in agriculture. Ferbam is not included in the A H S, and therefore this study does not provide information for this repo rt. I V
. 

### CONCLUS I ON 

### Based on the low frequency and severity of incident cases reported for ferbam to both IDS and SENSO R

- Pesticides, th ere does n ot a pp ear to be a co nc ern at thi s tim e th at wou ld wan-ant further investigation. The Agency w ill con tinu e to monitor the incident information and if a concern is triggered, additiona l ana lysis wi ll be includ ed in the risk assess me nt
.

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