# EPARegistrationNumber 66330-324 Vol. 1

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# (



# •
• August 15, 2005


### Ms. Joanne Miller, PM 23 Registration Division

- 7505C Office ofPesticide Programs U.S. Environmental Protection Agency Crystal Mall 2, Room 266A 1801 South Bell Street 

### Arlington, V A 22202 

### Subject: Agency Letter Dated June 13, 2000

DearMs. Miller: Please find enclosed the aflidavit for the 

### previolls year as required 

### by the Agency letter dated June 13,2000. Should you have any questions in regardstothis submission, please 

### donot hesitate to call me at 901-432-51 18. Sincerely,

## '~

# bWllGc-0~ Bill Washburn Regulatory Affairs Manager**~-)O** 

### Be/ 772099 •

# ,



# •
• Affidavit
Pursuant to the letteragreement with EPA ofJune 13, 2000, Micro Flo Company LLC ("Micro Flo") hereby affirms (1) The source ofthe active ingredient in each Micro Flo technical product is the approved source listed on the Confidential Statement of Formula (CSF); (2) This affidavit applies to the following products: Acephate Technical Bifenth(tn Technical 

### Ethephon 65 MUP iprodione Technical Mepiquat Chloride Technical Permethrin Technical Thidiazuron Technical Thiophanate-Methyl Technical (3) Micro Flo has not imported technical grade pesticide products otherthan those specified in Micro Flo CSFs for products intended for sale and distribution in the United States, and (4) All Micro Flo**end~use** products offered for sale in the United States were formulated from technical grade pesticide products specified in the applicable CSFs. (5) I understand that it is a violation of 18 U.S.C. Section 1001 to knowingly and willfully make any materiallyfalse statement or representation to EPA. Ifurther understand that Micro Flo may be subject to enforcement actions based on the statements in this affidavit.

Micro Flo Company LLC 

### By 

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# Ji;rrb

William C. Wisdom Managing Director



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Numbor LLC/51036-402 4: .Company/Product lNamlll 2. EPA ProdUCI Manager J, 

## Mm., PM' 23 3. Pfllpoaed Classification

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# 0 Ro.tlicted Micro Flo Company LLClThidiazuron Technical ,,'-,- -,- ,"-
. 5. Namll Imd Addrll$s III Applicllnt {Include ZIP Codfl/ Micro Flo Company LLC P.O. Box 772099 6. Expedited Reveiw. In accotdance wilh FIFRA Sectitm 3{c)f3t (b)(il. my ptoduct is simil3t or idenlical in composititm and labeling to:**,,~ennessee** 38117-2099 

## U ChtICk ifthis isB newaddrll$$ EPA Reg. No. _____**~~~~~** __**,_,~** ___._.__**~_** 

# .i.CJ Amllndmont

- Explain billow. 

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Final printed lobels in rep.onsll to Agllncylettor deted "Me Too· Applicotion.**~** RlIsubmiuion in rO$ponn to Agllncv IlIttllf doted**~**___ 

### 2/6/03 

# o Nlltiliclltion· E"pillin billow. 

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- Explein below. Explanation: Uall IIddit;lInel plIgels) il nllclllsary_ IFor slIctllln t lind Svctilln 11.1 Resubmission ofnolmcalion in response 10 EPA leller 2/6/03.**-~~-~** PerPR Notice 98-10 SeclionVI. Nolificalion oJAllernale Brand Name N-phenyl·N··1.2.3·lhiadiazol-5-ylurea TGAI 

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,b•.**N~.** Pam BlUce Tid
.. Fedetal Regislrations Specialist Telophontl No. IInciude AreaCodel 9011432-5000 Certification Icertify thllt th., statllmonts IhaYII made lin this form and all otta<:hments thareto ere ttue. eccuroto ond completo. Iacknowilldgll that anyknowfinglly fofu or mi51eeding at.tamontmaybe pUni,h4ble byfine orimpri"'rvnenl or both Undlll IIPPlicablo lew.

4.Typed Nllmll Pam Bruce
EPA F«m 85'0·' '''''.3·94' I editilln. ere 3. Till' 

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## •• • • Federal Regi5lrationG Specialist 

### •••••• • •



### •• 2/14/03 

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- EPA Fito Copy (original) 

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• il3/06/03 THU 09-: 22 FAl 901 432 5040 MICRO FLO 

# MICAOlAFLO**'lilIll'!mrHmrn~'<IJl'Bom:ooN**

# C OMPANY

DATE: 

### March 5, 2003
RE: Thidiazuron Technical, EPA Reg. #51036"402 Notificationof

### Altemate Brand Name 141002



# CERTIFICATION STATEMENT NOTIFICATION MAR 0 

## Ii 2003 NotificatiQn

## ofaddition of

### Dest per PR Notice 98cl0 

### This nOtification Is consistentwith the proviSions 

## ofPR'Notice 98-10 and EPA regulations at

## '10 CFR 

## 152.46, and no otherchanges have been made

## to the labeling or the confidential statementofformula ofthis product. I 

### understand that itis aviolation of 18 

### U.S.C. 

## Sec. 1001

## to willfully make any false statement

## to EPA. 

## Jfurther understand thatifthis notification is not consistent with the terms ofPR Notice 98-10 and 

## '10 CFR 152.46, this product may be in violation ofFlFRA and 

## I may be 

## subject

## to enforcementaction and penalties undersections 12

### and 14

### ofFlFRA.

# 'k?mlfu~ Pam Bruce Federal Registrations Specialist

4

# •

• For Cotton Defoliant Formulation Use Only 

## N-PHENYL-N'-1,2,3-THIADIAZOL-S-YLUREA TGAI ACTIVE INGREDIENT: Thidiazuron*.
. . . 

## INERT INGREDIENTS:. TOTAL: *N-phenyl-N'-l,2,3-thiadiazol-S-ylurea . 98.30% 

### 1.70% 

### .100.00%



## KEEP OUT OF REACH OF CHILDREN CAUTION 

## NOTIFICATION FIRST AID 

## IF INHALED: • Move person to fresh air. 

# • If person is not breathing, call 911 or give artificial respiration, preferably possible. 

## MAli 0 ti 

## 2003

an ambulance, then mouth-to-mouth, if

• Call a poison control center or doctor for further treatment advice. 

## IF ON SKIN OR CLOTHING: • Take off contaminated clothing. • Rinse skin immediately with plenty of water for 15-20 minutes. • Call a poison control center or doctor for treatment advice. 

## IF IN EYES: • Hold eye open and rinse slowly and gently with water for 15-20 minutes. • Remove contact lenses, if present, after the first 

### 5 minutes, then continue rinsing eye. • Call a poison control center or doctor for treatment advice. IF SWALLOWE0: • Call a poison control center or doctor immediately for treatment advice. 

# • • 

# • Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by the control center or doctor. Do not give anything by mouth to an unconscious person. poison
•

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# . EPA Reg. No. 51036-402 AD Oll003 EPA Est. No.**XXXX-XXX~XXX** 

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• Manufactured 

## By: MICRO FLO COMNPANY LLC 

### P.O. BOX 772099 

### MEMPHIS, TN 38117 PRECAUTIONARY STATEMENTS HAZARDS TO HIJMANS AND DOMESTIC ANIMALS CAUTION. Harmful 

### if swallowed, inhaled, or absorbed through the 

### skin. Avoid breathing dust. Avoid contact with skin, eyes, and clothing. Do not contaminate food or feedstuffs. 

### EMERGENCY TELEPHONE NUMBERS: (800) 424-9300 (CHEMTREC, 

### transportation and spills) (800) 900-4000 (Poison Control Center, human health) (800) 345-4735 (ASPCA, animal health) DIRECTIONS FOR USE 

### It 

### is a violation of Federal law to use this product in a manner 

### inconsistent 

### with its labeling. Labeling for products formulated from this product must conform to that which is currently registered with the u.s. Environmental Protection Agency. Only for formulation into a defoliant, for the following uses: 1. 

### Terrestrial F'ood Crop: Cotton
. 

### 2. Uses for which U.S. EPA has accepted the required data and/or citations of data that the formulator has submitted in support of registration. 3. 

### Uses U • S • 

### for EPA experimental requirements. purposes that a ro
ENVIRONMENTAL HAZARDS 

### in compliance with

Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or publ.ic waters unless this product is specifically ident i f 

### ied and addressed in an..**·~~.oES** 

### permit
_ Do not discharge effluent containing this prodJ:c't" to sewer systems without prevj_ously notifying the sewage**tr;a.~~ent** 

### plant authority_ For guidance, contact your State**~~~~r Boa~d**  

### or Regional Office of the EPA. : .: ••• 

## •• • STORAGE AND DISPOSAl, 

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### Do not contaminate water, food, or feed by storage or disposal. STORAGE: 

### store other pesticides, 

### product in original 

### fertilizer, food or container feed. 

### only, away 

### from

PESTICIDE DISPOSAL: Do not contaminate water, food or feed by 

### storage or disposal. Wastes resulting from the use of this 

### product may be disposed of on site or at an approved waste disposal facility. CONTAINER DISPOSAL: Completely empty liner by 

### shaking and tapping 

### sides and bottom to loosen clinging particles. Empty residue into manufacturing equipment. Then dispose of liner in a sanitary landfill or by incineration 

### if allowed by 

### state and local authorities. If drum is contaminated and cannot be reused, 

### dispose of in the same manner. DO NOT REUSE EMPTY CONTAINER NOTICE OF WARRANTY 

### Micro Flo Company will not be responsible for losses or damages resulting from the use of this product in any manner not specifically recommended by Micro Flo Company. User assumes all risks associated with such non-recommended use. Micro Flo Company warrants that this product conforms to the chemical description on the label thereof and is reasonably fit for purposes stated on such label only when used in accordance with directions under norma} use conditions. It is impossible to eliminate all risks inherently associated with use of this product. MICRO FLO COMPANY MAKES NO WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR IMPLIED WARRANTY EXCEPT AS STATED ABOVE.



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• 113(06/03 THF 09,: 22 F.U 901 432 5040 .1HCRO FLO 

# FAX TRANSMISSION Micro Flo Company Regulatory Department P.O. Box 772099, Memphis, TN 38117 (901) 432-5000 (901) 432-5031 EClX

TO: JOl'ce 

## Edwards # 

# of Pages,_2_ (Induding CoverPage) 

## COMPANY: 

## US EPA FAX#: 

# ']b3-!f)5-{eQ?-Q

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## FROM: 

# /1lrnmw DATE: 

# ,3-k03
COMMENTS:



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# f-- Registration oPP ldentifior Number 

### Environmental Protection Agency 

### f-- Amendment 

# 293559 We.hington, DC 20460 

### Other L..- 

### ilor ,

# - I 1. CompanvlProduct Number 2. EPA Product Manager 3, Propo.ed Clnllifre.tion IName) 

### PM' 

# DNol'lO 7 

# D Restricted

:5. Name and Addr
... of ApplieDnt (11If::lude ZIP Cod., 

### 6. Expedited Review. In FIFRA Section 3(c)j3) 

### (bHiI. my product is similar or in composition and labeling 

### to: 

# /

EPA Reg. No. 

# n Chtwk ift;hj$ is • nowadwtl$$ Product Name 

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# ~ Amendment· Explain belew, 

# 0 Final printed r.. ·porae to Ra.ubmi
.. ion in re.pon••to Agencylener datod 

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# 0 Notifie.tion· Explain below. 

# 0 bofow. 

# ! Explanation: u••additional peg.ts) It n.c.... ry. (For lIection I end Section II.)



### , - III**~** 

# ,-,;;;- / Child-R•• istant Packaging**u~Pacl«lgin"** 

# / I**~.r** Soluble Pack8Qing 2. Typo ofContainer 

# •a::·- _ V•• 

## I--- VOl

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# . Pl._tic No No Glasa

a Certification must If

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## Ilf

# -Y,,- No. par p..., Unit Packoging wgt'l / 

# w'" cantlinor Other be submitttHf I 

# r3.

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# o ConUliner 

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# ID lobo! 

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# ","""" 0" 6. Menner in Which Lobel ;. Affixed to

# ptet o Other 

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# / , -IV 1. Contact Point (Compltlfe below (Of 

# , " o b. fO PfOC8S$ this 

# ,**N~.** 

# / Titlll Telephone No. (lncluda Aroo Code) 

### Certification 6. Ooto**App1ic~'IIion** I certify that tho .tlll8monts I hIve mlldo on this lorm end 011**onachmont~** thGreto or. tnro, occuroto and complete. Rllcoived I ecknowledgo tIuIt onyknowinglyfalso ormisloading statamant may be puniGhablo byfino or imprisonment or both Undor applicablalow. (Stamped)
2. Sigl\Bture 3. TIllo 

# 14. Typed Non,. 5. Data 

### 9 EPA**F~m** 8570·' 'R._,
...., seditions arll 

# , WhIu
- EPA FUa Copy lorIglnall Y_Now

-**AppU~t** Copy**------------~~~---**

PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS
PAPERWORK REDUCTION ACT NQTICE: Public reporting burdon for thi, coUection ofinformation is ostimated to IlYi1rogo 0.B5 hour per rot>pon!lo, ineluding time for reviewing iru:uuctWQ$, £IUIrching existing dete $oure(l$, oethoring and muintuioing the dotl! needed, and clIfTlploting and reviewing the collection of information. S,nd COl'lT\1etlts rogarding tho burden estimole or anvoth.r aspect of thi$: collection of informtltion, including suggutiom, for reducing this burden, \0 Chief, Information Policy Bronch, {2136), U.S. Environmental Protoction Agency. 401 M Street, SW, Woshington, DC 20460.

### 1!!:lJilll!i1l;rm!!!~, Thill form ill to be u"od for aU oppliclltions for now rogistretion, ond uso reregistration, amendment. r.$ubrnl$lIion, to applications for notificotiont, I printod labeling, reregistration, etc. In order to procass on application for a now ragistration aubmittad on thill form, tho following materiel mutt aecompany tho eppliclltion: 1. Cartificotion with**Ra~oct** to Citation of Data (EPA Form a57().29). IIf Mt exomptod by40 CFR 152.81 fbI {411; 2. Confldontial Sttltoment of Formulll (EPA Form 857().4); 3. Formuletor'a Exomption Statamant (EPA Form 8570-27); 4. FiVil copiat of drllft laboling; 5. Trnllo oaple. of anydata 8ubmitted; 6. Authorillltion lattor whara applicable; 7. Matrica. whero appliCllble. 

# I""t'mii••**I~** of Labeling" Labeling should first ba oubmined in tho form of draftI,bllls wilh 1111 applications for new ragi§trelion. Such draftIllbflls m",b'l of typed labal taxt on 8.5 x 11 inch paporfor aubmiuion or a mockup of tha propoaed Icbet If prepar,d for mockup, It should ba 

# I",,,,",<od in a wav as to faciliteta stor'ga in 8n 8.5 x 11 inch fila. Mockup lab,ls significentiy smaUer than 8.5 x 11 inches ehould be m"",,,,,d**'o~** paper for eubmiesion. 

# I,,"',ml••ionof Data" Data submittad in support of thie 8pplication mu§t be submitted in eccordenca with PR Notico 86·5.

### 1~!!'J~a!];U!:lJgRIil;:r];!.!ll$.; 

## .. Plaeso rosd tho instructions listod below before completing

### thi~ application. First datermine the typo of

### ragi~tretion in Block A. for which you ara submitting this application. For applicetions submitted in connactlon with Now Rogistration IIction" Sectiol'\$ IV must ba completad bytm. applicent. For epplications submitted in connoction with emended raugi§tration aClion,. rosubmisuions,**;:::'o::';~~~';'** reragistratione. otc.• Sactions I. II, and IV**mu~t** be comploted by the applicant. Chockthe IIPproprieta ection for which you era submitting thi' form.

### 1~il1QJ[!l~U**~** This lIection mustbe complatod, all applicabla. for all registration ections. 1. CompanvlProduct Numbar • Insort your Compeny Numbor, if ono has been a$Signad by EPA. This number mey havebaon eSllignad to you**o~** e ballic ragictrant, a distributor, or all an astablishmant. If your product is registerod, insart tha Product Number. 2. EPA ProductManegar

- If known. fill in the nnma and PM number of tho EPA Product Manager. 3. Propoeed Clusificatlon • SpecifytM proposed Clllssification of this product. 4. Product Nel'M

- Enter the complete product Mme of this pesticide as it will appasr on the lablll. The nlUTlO muut be upeoific to this product ool.,.. Duplication of n&fl'lO$ i. notpermitted 1!IfT!0ng products of the $Ome compony. Do not include anvbrond narne or companyline ds"illn.ationr;. 5. Nema andAddre•• of Applleont· Tho MmII of tha firm Dr ponon end addross. shown in your**epp~cation** i& the per&on or firm to whom tho registration will ba illllued. If you oro actingin baholf of onothar party, you must IIUbmit authorillltion from thatpartyto act for thom in mattar•• An applicant not residing in the Unitod States must hovo on IIIUtlwriled agent residing in the United Statec to oct for thom in 1111 regilllretiQn mattars, TM name 111M complate mcillng eddru!I of such en egontmu$t accomplllnv this IIpplicotion. Expedited Review· FIFRA $ection 3 (c) 3 (S) provide
.. for IIxpeditad raview ofapplication; for rogilltrlltion. or emondmsnts to existingragistrlltions. thaI Me lIimilllr or identicoll0 othar pesticide product$ that aro currontlvregi$tared withthe EPA. In ordar for YOlJr application to be aligibht for expOOltad r"viow, you must provido us with tha EPA Registration Numbor and prodUct nome of tho prodUctyou believe is similer to or idonticnllO your product. Th
.. product mu"t bo**~miJar** or identical in bOlh formuhnion and labolad usa...

## ~::~~~,' This lI"ction mustbe oornplotad for 011 applicotions submined to l!IfT!and the r"'gilltration ooly of a currentlv r...giutored product for a rll$ubmiscUon In rellponse to lin Ag"ncVlanllr, for notifications to the Agencv, for lhe lIubmill.uon of final printod labeling. for 11M for anv other eetion thet pl!lrtains to a snecifio EPA'regjstllrl'ld prodl/ct. This 8IIction Is.!!.!2! 12!2! ueed for a now eppliclltion for ragistretion. 1. SubJ-ct of submiulon

- Cheek the applicable block and provide th. AgoncV lotter date if appropriate. Provide a briof oxplanalion of thll purposelsl for the submission, such"**~thl!l** (lljdition of 8**~ile,** pest or crop**{$pecifyJ~; ~amend**  the Confidential Statoment of Formula bV

...**~; ~reregi$tration** **IilUbmi.uion~; ~oanllrallobol**  r.vision of usa directionll.**~** Attach a &aparote pnga If (lljditional &paco is neadod.

### ~~~~~~ lPackaging and Container Information)" Thill Saction mUllt be compJet&d for allopplications submitted In connoction with new or appIiaable amendments. Type of Packeglng- Chocl:: the approprinto block if your product wlH be pe.ckegad in the indicoted pe.ekaging**typo~.** Indicat$ the aile of the individual packtlts and numbar per**rota~** container. Type of Retail Container ·lndical0 type of containar in which product**w~1** be me.tt.tad. Location of Not ContenU -Indicate thelocation of the not contents information for your prodUct. SileJ.) of Retail Container

- SpacifVth$ net contents of .U retoil containalt for your prodUct. Location of U
.. Dintetione.

- Indicote the locetion of the Ulla directiolUl for your prodUct. Man/'Ief In which Iabe) '- off!XCId 10 pwduct • Indicated tho method prodUctlabol ito ettechad to retail container.

### ~~~~t!;~ fContact Point}

- Thill Saction mullt bo completad for 011 IIPPlice.lionll for Registration actioni'. ;'0., now productll r..gislretian,**~mo-too, ~**  reragiltretion. etc. 1-5. Solf·axplaMtory. •• EPA Un Only. 

### 10I**-~** ---== ---- ---- 

## • PI.IIUI"";**'-~"on** 

### ,.-;.,..bMotfIco form. FormA**ro:v~.** OMS No. 2070-0080 , , United Stete, 

# a Registration oPP Identifier Number 

# &EPA Environmental Protection Agency Amendment 

# 293559 Washington. DC 20480 

### Other Application for Pesticide
- Section I 1. Compeny/Product Number 2. EPA Product Mllnager 3. Propeeed Cle
.. Wrcetion
4. Compeny/Product IName) 

## PM, DNone D Rllltricted
5. Name and Add"
..of ApplIcant (Includ. ZIP CDde) 6. Expedited Review. In accordance with FIFRA Section 3(cJ(3} (bHi), my product is similaror identical in composition and labeling to: EPA Reg. No. 

# D Ch.ckifthis isa n.wlIddru$ Product Name 

### Section
- II

# ~ Amendment· Explain below. 

# D Final printed lebol' in re.pona.e to Agencyletter d.,ted Ruubml
.. ion In roepon,.to Agency letter deted 

# D ·MII Too·**~pplic.tion.** 

# D Notificeoon· Explain below. 

# D Other· Explain below. Explanation: u•., eddJtionlll pegel') 11 nece.. ery. IFor lIection Iand Saction II.)

, ,

, 

### Section
- III 1. Metorial Thit ProductWIlla. P.ekepd In: Child-Re,i$tent Paekeging Unit Packaging Weter Soluble Packeging 2. TVJ)e of Contlli".r 

# •B::'- Bv" , 

# B V

.. 

# §M"

. No No Pla.tic Gla
.. e Certification must If ·V
.. - No/por If-V
.. • No. per Paper Unit Packeoing wgt. contain" Peckogo wgt contain" Othar ISpecify) besubmitted 

# , , 

### , 3. Location of Not Conlonte Information 4. Sizels) Rotei! Conteiner 5. locatiOn 01 label Directiens



# D 

# o Container 

# B On label LobO On labaling accompanying prodUct 6. Manner in Which label i. Affixed to Product

# ~ UtMgraph 

# o Other

, Pap.r**~Iuad** Stenci ed



### , Section 

# - IV 1. Contect Point (Complere rftlf1l.S 'dirBcrlyb./owforidtmrificstron offndividual to be contlilc/.d, ifnllClIsssry, fo proCII$$ thrfillf!p!icarion.)**N~,** TItle ToJophone No. Unclude Arae Codo)
Certification 6. Oete Appiicotion Icertifythat the s;t8temenlS Ihavo mllde on this form and all enachmenl$ thllreto ere truo. accurete end COmpletll. Recaived Iecknowledge thet anyknowil'lgly fals. ormisJeeding lIlatemantmey be punishable byfino orimcrilOonmont or (Stamped) both und.r applicable lew. 2. Signature 3. TItle

4. Typed Name 5. Data 11 " EPA Form 8570-1 meV. s-.S4) PreVloU, edition, era obsolete. Whlu. •EPA FIle Copy lorlglnall Vellow

- Applle&nt CopyPAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS PAPERWQRK REDUCTION ACT NQTICE: Public reponing burden for this co!i/)ction of information is cSlimat&d to average 0.85 hour per**rs~pon,;o,** including time for roviewing iootructiol<S,**~srching** IIxisting dotn sources, gllthurlng end mllintuining tho data neoded, llna comploting lind reviewing the collsction of ;nforma-Jon. Send comments regardingthoburden**'!ltim~te** or any other .spect 01 this collection ofinloITnelion, inc1ua'og l>uggll$\ions for ,,,dueinQ this burden. to Chiof, Information Pelicy Bronch, 12136), U.S. Environmental PrOIOClion Agllncy, 401 M Strllot, SW, Washington, DC 20460. INSTRUCTIONS: Thie form is to bo used for an IlppliCelions for OIIW registrOllon, end use reregistration, amondment, rllSubminion, 10 oppliclltions for nOlifications, final printed labeling. rereQ',;;trDlion, elC. In ordor to process en I'Ipplication for 10 new registration 6ubmitted on this form. the following !1"I3Ullial mullt Mcomparw Ihe application: 1. CortifiolOtion with Respect to Citetion of Dllta (EPA Form 6570-29). {II not eXempted by 40 CFR 152.$t Ib) (4)); 2. Confidential SUltllmont of Formule IEPA Form 8570-41; 3. Fotrr'llJlotor's Exemption Stetemll'nt IEPA Form 8570-27); 4. Five copios ofdroft Illboling; 5. Throe capilli of anydate $ubrniuod; 6. Authorization lotter where &pplicobl&; 7. MatriCOI where applieablo_ Submiull><l of I..beHno
_labeling should first be aubmiu&d in the form of droitlabeb with all epplicotiom: for now registrOlion. Such draft**11lb~ls** may bo In thl!; form oftyped lablll t"let on 8.5 x 11 inch pllp&< for eubmin;on or a mockup of the propooed label. II prepered for mock.up, it should be • con§tl1.Jcted in a way as to facilitate storoge in on 8,5x 11 inch file. Mockup labels significantly emallor than

## a.s x " inchos shouk! be mounted 0 x 11 inch peper for subminion. Submlulon of Datil' 0&\11 subm1nsd in &UPport of lhis application must be submittod in accordance with pR Notice 86-5. SPECIFIC INSTRUCTIQNS:**Plell~e** re&d the in&tructions listed bolow boforo completinn this IIppliclltion. Fir&t dotermino tho type of rsgl$.,,,tion tlction. lililtod in Block A, lor which you tiro lilubmitting thi6 eppllcation. For**~plicatio!J6** :;ubmiued in connection with New Regi§lration actionlil, Sectionlil I, HI, ar.d IV must be compleutd by the epplicant. For applicalions submitted in connection with amended rerbgi$tratilln action$, r!)$ubmi$$ion$,**notification~.** reregi$trl.ltionS. ote., Sections I, II, end IV must be completed bythc applicant. Block A· Chock the appropriote action for which you are submitting this lorm. SECTIQ!Y.l- This section must be complllled, e§ IIppliceblll. lor ell registration ectioOll;. 1. ComplOtlylProdul't Numb.,r

- In$el1 YOUI Company Number. il OM has boen ossigned by EPA. This number mayheve bO(ln ,,,,,signed to you as e be$ic rogi:;tranl, a distributor, or liS an cliltsbllshmenl. II your product is regiOlorod, insert the Producl Number. 2. EPA Produl't Manllger· If known, fill in tha nome and PM nUmbllr of tho EPA Product Monegsr. 3. Propgsed CI
..."llicatlon

- Spocify tha proposed cls$sificotion of this prC>duct. 4. Produl't Name· Enter thll complete product nMTl1! 01 this pesticide ea it win appear on tho label. The narne muDI ba specific to thig product only. Duplication of nameG is not permitted amongproduct& 01 tha some company. Do not include enybrsnd nome or compllnylimil deliligmiltioOl •. 5. Name andAddra
..ofApplicant

- The nDmO of the lirm or pefflon and eddrcs1l shown in your application is thll pereon or firm to whom the registretion will bo iuued. If you are acting in behall of enother party, you must submit outhorization from thllt partyto aot for them in reglstretion msnen:. An applicent notruiding in tho Unitod States mugt hllvlI sn**outho~z&d** agant residing inthe United Stetes to ect for thom in ell • rogistration mattllrs, The nl.llTle and completo mailing address 01 such tin egent rruJlII eccompany this nppliclltion, 6. Expedited Relllew

- FIFRA aection 3 {c) 3 (S) provides for expedited review of applications fOI registrelion, or amendments to e)Cisting registretions, thet ere ,imilar or identical toother pe;tlcide product' that IIro currontly registarad with tn. EPA. In order for your applicotion to b(l eligible for exp&dited raview, you muatprovide U$ with the EPA Rllgistration Numbarand product nO!1"l3 of the product you boliova is ,imilar to oridentical to your product. Thr.t prodUct mustbe cirrular or Identical in both formulation end laboled usell. SECTION II·Thi, lIection fT\UfI be oompleted for all opplicetionc eubmitled to errand tho regietrotion onlyof a currently regietered product IAmendment), for a rcpubmisslon In l'1IepoO$O to on Agency loner. for notificationl to Ihe Anency, for thellubmiulon of fine! printed lebeling, for roregistretion end for enyothr.tr action that porteins to a specific EPA-rogiiter&Sl product. This section ie!l2!

### 12.1u! uoed for a new application for rogistratlon. 1. Subfect o(submi
.. lon • Check the applicable block lind provide the Agoncylettsrdete if appropriete. Provide a briof explenetion of tho purposels) lor the wbminion, such 0$ *tn. addition of e site, post or crop (specify)-; *arnand the ConfidanticJ Statement of Formula by
..."; -roregistrlllion wbmi.$ion"; -g.norallebel rovi,ion of Ulle directions.- Anach a 'opllrato psg. if additionmspace is n$edod. SECTIQN 

### III (Peckllging end Container Information!

- This SlIction mutt be comp)oted for ell epplicillions submitted in connection with nllW regic-trat!on or oppIiGeble emondmontJ;,

,. Type of P.ekllging

- Chr.tck thr.t appropriato block jf your product**w~1** bs peckegod in the indicated peckllging typell. Indic.te the**si~o** ofthO il'ldividuel packatll and number per retail container. 2. Type of A.t.n Contelner

- Indieeto type of contuinor in which product will be merkoted. 3. lec.tlon of N.tContente

- Indicate thelocetion of the nat conlOnt. Information fer yourproduct. 4. Siu{.! of Retait ContaiMl'

- Spoclfytho notcontantll of all retail container. foi YClUr prodUct. S. loution of Us. Dinetiorw· Indicate the location 01 thll un directions for your product. G, M.nner in which label. affixed to product-Indicated the meth2d product Illbelis ettached to rll1ail eontainor. seCTION IV IContoct Poinl) • Thill Section must be completed for ell eppliclltions lor RegiGtration**ection~.** 1.0., new prCtducts regilltretion, relHJbmisJion, -mtt-too," rarogi.tration, etc. 1-5. Sell·explanatory. 6. EPA Ua. Only, 

### 12I



# • UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 2D46D

OFFICE OF PREVENTION. PESTICIDESAND TOXIC $UBS1N,CES



## Ms. Pam Bntcc Federal Registration Specialist Micro Flo CompanyLLC P.O. Box 772099 Memphis, Tennessee 38117-2099 February 6. 2003

RE: Notification ofAdditional BrandName: Thidizuron Technical EPA Reg. No.: 51036-402 

### Submission Dated: February 6, 2003 Dear Ms. BOice: 

### The notification 

## referred to above is incomplete and cannot be accepted at this time. A notification labelingchange must include a copyofthe label with the changc(s) clearly marked. Please referto the PRNotice98-10 Section VI and resubmityom notification. 

### Any questions thatYOli may have concerning this action, please contact me at 703/305-5479.
Sincerc£,

N 

## ti cations Review Coordinator R 

## g" tration Division (7505C)

13'

# 5L

. F, 0

.... No , M •.



# . 

# § Registration opp Identifier Number 

# &EPA United Stal•• 

### Environmental Protection Agency Amendment W81hington, DC 20460 

## v Other 

### for 

# ,- 

# , I I. Company1f>roouctNumb.r 2. EPA Produet Monagor 3, Propos&<:! Classifieation Micro Flo

### Co I I r. J. MHle<

## ~N.'" 

# D R
.. tricltK!

## 4~icm Flo INam
.., PM, LLC/Thidiazuron Technical 

### 23 Nomo**.~** Addross of Applicont (lnclud. ZIPCoda) 

### 6. Expedited Reveiw. In accordance with FIFRA Section 31c)j3) 

### Micro Flo Company LLC Ibllil. my ptoduct is similar Of identical in composition and labeling 

### P.O. Box 772099 to: 

### Memphis, Tennessee 38117-2099 EPA Reg. No. 

# D Chock ifthi1l ;$ II now (lddrfl$S 

### Product Name



### , - II 

# D Amondment· Expl&in bfllow. 

# 2J Final printed lablllls in 'fIj'l.onso 10 

# D D AgoneV rotto, dOIM

--- Rosubminionin r"Rpons" 10 Agoncvlotto, doted. -MeToo· Application. Notification· EXplain below. 

# D Olhof' Explain below,
Us.additionol pag..CsI if n..cessary. IFof .ection Iend Section 11.1 NolmealionlorAllernale 6rand Name: N·phenyl·N',C ,2,3·thiadiazol·5·ylureaTGAI



### -III 1.**M.~ri"** no;. "'
.... 0< ""

.. 

# ,**~,** 

# i Unil Packaging Wet". Soluble Pack"ging 2. Typ" of Conlainef

# ~V" ,- V" 

### - V
..

# ~..."

# .. v N.

# ~ 

# N.**~** PI
..tic 

# N. Glan 

### * c.tificationmust**u~;**

# .., No. p.f

### ',~;::,; w,l**~~:.rf** Pllpef wgl. conl";nO' conl";n.f

..... OIMr 

# i liberdrum 

### M $ubmittfld I 

# e.' N", !4.

# Si,.,.,,,,..,

# IS~ ,., ......11



# ...b., U 50 Kg 6. Mannlfin Which Lobol i. Aflixed 10 Pfoduci 

# 1-'**~i** U 0,",.,



### , -IV 11
. Coo,."

# P.i., • ifom•. .. 

## •b., "hi

..

### IN~' Tltlo

## .n'.~Alal Cod.) Pam Bruce Fedetal RegisetationsSpecialist Certification Icertilvthallhe $lot_nI5 Ihivi madl on this fo"" aod aU Ittaclvnenl. Ihefolo afa trul, .ccurala Ind cWI&: Iacknowledge thet any**kf\(lw~nglly** 1$1$0 Of misleading 5111etmenl m&y bapunishablo by fino orimprilonmet!1 Of • 

### • IS,""""'I bOlh urKI.r I lew. • ••••• 

# .. •• •••• 2. 

# i J, TItle 

## • • 

# r1LvY!**T~{** II

## (X ••••• •••• Federal RogiSlralions Specialist 

## • • ./ 

### ••••• •••• 4. Typed Nema S.Oal* 

## • • 

## .'

# .. Pam Bruce 

### 1/28/03 • • 

## • • •



# .... "'.'Mm
.. 7.·1 ,....

# "34"
, O(Iitiont .fa obsoloto. 'MWUo ' EPA FlIrt Copy lorioInal) 

### V_·. , ",<, 

### 14

# •
• J["c;:" d l',o,., 

### '"Y,**;-r"},,",,~** h"'l"''-'''''>'_''' :l:'.'l""" O:,Q',c;

-'Oll F""""\"""",, ;"-'.' .• j .w.

;';',,'b, ",;[."", 1,.("**~G·lf.J** 

### NOTICE OF PESTICIDE:**~** 

### Registration



## ___ Reregistration

Micro Flo Co. LLC 

### P.O Box 772099 Memphis, TN 381 17 fFi\ ''''{j.**~;",_** t;" ,- : 

### 51036-402 Conditional


### THIDIAZURON TECHNICAL

Noto:**t:h~"g'-'~** "" ""'01,,,,) :lltf"",,g Lll**.,,)b~t"';"'"** ()-"", lh'''' "",,,c'I",,:-(] '"**"O'''10''''-~O''** WlLh Ulis r·"lJSl,-"U.O'-,**r""~,·.** 11".**"dA'iL~'~d** lo und "cC'-,pt;"d by >-I",**r\",q;"t,-~t"x, Db;~,on**  rrio,. to '.!::;" of til!' l"bGi in """"e,CC!. 1" ,"",y**'_"",-("sp"~d'Ol""_c',** "" U>b [H",h.,:**_,l"'~y~** ,",H-"'- t" i.Il'· .,hov", tPT< rC9"'U",;t;o1 Jlu,obc", lJ._**l,.,~",** {,r ,"f,."",,,""" (""_,;i,,,d joy lh'"' ".,,,":.,,,,,,(, (l,,, "V,v,_,**"',".~d I'nAi'_-~<k'**  '" l,.",,_"_'y "_<IC3t"I'RCi,-'_**·_"1~3\",-.'d** '.:"i'" '_j", 

### r-",,·,·,-,,) ,,,-..-;r:,,,,d,_-,**,'u,ql~"k** _,,,J**1':"l1~'''\I-;,d,,"** "":.
III "td"," lo F'U".,:l ],'o_,H" ,,,,,I "'" ,_-,,,),,,,,,,,,, 

### ,j,,_- Ad,,, "";''-'''''''''-. '," b', """ )Un, 

### ""y ,)" ''''Y ,-"",_, """I"""'; '"**'_'!''''::~'c** ,jp,:**:"~9j"t'-,ll"1l** 0:' \,'o':)('lo,· f" _.,xnClhll,_'"**"',~h** til"**'\c~,** j'h"**~:cc,_,p:"n..;-""~** ""Y ,,,",.,_, ",**'CGl",.,.,c~'''n** KII, 'h"**r,""j~":,",-,,,** ,,(,' i',,,,,,,n**,,,,~.-,,** th' ,;-( J:_ ",,: te, C"_'**ce,,~l'-~"d** ,,', <;l-('"", ,b"**,-.-,,-,)~L)-dr;,_** d r,,,llI 'J'


### This prodlTct is conditiol1nlly registcred ill nccordallcc with FIFRA sec. 3(c)(7)(A) provided that you: S11bmit and/or citc all dnID rcquired for registrntion/rcregistrillion ofy01Jr product whcn thc Agency recplires nil registrants ofsimilar products to submit slleh dati1. 2. Make the following: labcl changc:

a. Revise the EPA Registration Number to read, "EPA Reg. No. 

### 51036-402"
. b. Within thethird 

### (3) paragraph underthe head'lI1g entitled 

### "NOTICEOFWARRANTY," revise "PURPUSE" to rend as "PURPOSE" 3, Submit, within six (6) months ofthe date ofthis rcgistrationl1oticc, thc solubility ofthc Thidiazuron technical in organic solvcnts. Alternatively, )'011I11ay**~m1\'idejustification** 

### for a waiver ofthis data rCC]1lircmcnt 4. Submit, witiTin six (6) months ortllcdate ofthis registration notice, the completed storage**~t<lbjlitylcormsion** 

### characteristics df-'J![I 

### oftile Thidiazuron technical in organic solveJJ!s. Altcn)(;ltively, you may prO\'idejustification for 11 

### waiver ofthis data rcquircmcnt. 5 Submit two (2) copies ofthc revised final printed l;lhel for the rlOcord

"", 

## JAN 0 2003

15 

### I 

# I-- ----

# -------

- --- - ---- ----------- -,



### page 2 EPA Reg. No. 51036-402

Iftheseconditionsarenot complied with, theregistrationwill besubject to cancellation in accordance with 

### FIFRA 

### sec. 6(e). Your release for shipment oftile product constitutes acceptance ofthese conditions. A stamped copy ofthe label is enclosed for your records.



### Joanne 1. 

### Miller Prochlct Manager (23) 

### Herbicide Branch Registration Division (7505C)

• Enclosures


# •

16

# •
• ------------------,

For Cotton Defoliant Formulation Use Only 

## THIDIAZURON TECHNICAL ACTIVE INGREDIENT: Thidiazuron*. 

## INERT INGREDIENTS:. *N-phenyl-N'-1,2,3-thiadiazol-S-ylurea 

### . 98.30% 1.70% .100.00%



### KEEP OUT OF REACH OF CHILDREN CAUTION 

## FIRST AID IF INHALED: • Move person to fresh air. • If person is not breathing I 

### give artificial respiration, possible. call 911 or 

### preferably an ambulance I 

### then mouth-to-mouth, 

### if
• Call a poison control center 

## advice. or doctor for further**tre~:~~'1Emt** 00 0 

### IF ON SKIN OR CLOTHING: o 0 0 o 00 

### • Take off contaminated clothing. ••••••• o 0 0 

### • Rinse skin immediately with plenty of water for 15-20**mi~t~s.** 

### • Call a poison control center or doctor for 

## treatment:advi·ce·. IF IN EYES: •• • :-: ••

### ••• ••• 

### • Hold eye open and rinse slowly and gently with**w~~~** 

### for lS-20 minutes. •••• o 0 

### • Remove contact lenses, if present, after the first 5**mi1"l.~es,** 

### then continue rinsing eye. :••••

, 00 

### • Call a poison control center or doctor for treatment**adv~ce** 

### . IF SWALLOWED: • Call a poison control center or doctor immediately for treatment advice. • Have person sip 

### a glass of water if able to swallow. • Do not induce vomiting unless told to do so by the poison control center or doctor. • Do not give anything by mouth to an unconscious person. EPA Reg. No. 51036- NET CONTENTS: EPA Est. No. 

## XXXX-XXX-XXX

Manufactured By: MICRO FLO COMNPANY LLC P.O. BOX 772099 MEMPHIS, TN 38117 ACC/i:PTED wilh COm.tENTS in F.PA Lo:tt
..r Dated



### 17

# •
• PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

### CAUTION. Harmful 

### if swallowed, inhaled, or absorbed through the 

### skin. Avoid breathing dust. Avoid contact with skin, eyes, and clothing. Do not contaminate food or feedstuffs. EMERGENCY TELEPHONE NUMBERS: (800) 424-9300 (CHEMTREC, 

### transportation and spills) (800) 900-4000 (Poison Control Center, human health) (aDO) 345-4735 (ASPCA, animal health) DIRECTIONS FOR USE It 

### is a violation of Federal law to use this product in a manner inconsistent with its labeling
. 

### Labeling for products formulated from this product must conform to that which is currently registered with the U.S. Environmental Protection Agency. 

### Only for formulation into a defoliant, for the following uses. 1. Terrestrial Food Crop: Cotton. 2. Uses for which U. S. EPA has accepted citations of data that the formulator of registration. 3. Uses for experimental purposes that U.S. EPA requirements. the has

are 

### ENVIRONMENTAL HAZARDS 

## • • •••• 

# .. . ., 

# . · ..**requir¢&:~ta** 

### add/or submitted**~n ~~H~Qrt**  

### •••••• •**F..** 

### in 

## • • 

# .. . ... • •• ••••• ••• 

### cqJIlp.,J..iance .with •

### ••• 

### • •



### •••• 

# ... . , 

# . · .. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or public waters unless this product is specifically identified and addressed in an NPDES permit. Do not discharge effluent containing this product to sewer systems without previously notifying the sewage treatment plant authority. For guidance, contact your State Water Board or Regional Office of the EPA. STORAGE AND DISPOSAL Do not contaminate water, food, or feed by storage or disposal. STORAGE: Store product in original container only, away from other pesticides, fertilizer, food or feed.

2 

### 18

# •
• PESTICIDE DISPOSAL: Do not contaminate water, food or feed by storage or disposal. Wastes resulting from the use of this pJ.-oduct may be disposed of on site or at an approved waste disposal facility. CONTAINER DISPOSAL: Completely empty liner by shaking and tapping sides and bottom to loosen clinging particles. Empty residue into manufacturing equipment. Then dispose of liner in a sanitary landfill or by incineration if allowed by state and local authorities. If drum is contaminated and cannot be reused, dispose of in the same manner. DO NOT REUSE EMPTY CONTAINER NOTICE OF WARRANTY Micro Flo Company will not be responsible for losses or damages resulting from the use of this product in any manner not specifically recommended by Micro Flo Company. User assumes all risks associated with such non-recommended use. Micro Flo Company warrants that this product conforms to the chemical description on the label thereof and is**reasonab*~.fit** 

### for purposes stated on such label only when used in**accO~.;.i~hce** 

### with directions under normal use conditions. It is**impossibl~** 

### to eliminate all risks inherently associated with use ot ·.khis 

### product. •••••• • • 

### •• • •

### ••• 

## • MICRO FLO COMPANY MAKES NO WARRANTIES OF**MERC~~~BILI~·** 

### OR 

## FITNESS FOR A PARTICULAR PURPUSE NOR ANY OTHER**EXPRES~'OR I~~~ED**  

### WARRANTY EXCEPT AS STATED ABOVE. ..:... ••• ••••• • ••••

### • •••• 

# .

, 

# . . , 

# . • •

## •

) 

### 19

# •
•**~~r** Cotton Defoliant Formulation Use Only**~**... 

## THIDIAZURON TECHNICAL**~/ACTIVE** INGREDIENT: 

### Thidiazuron*
. INERT INGREDIENTS:. / TOTAL: /' *N-phenyl**~N** ' -1,2, 3 - thiadiazol- 5-ylurea 

### . 98.30% 1.**70%~'---"** 

### .100.00%**~** 

### KEEP OUT OF REACH OF CHILDREN

- CAUTION 

### FIRST AID /-rF INHALED: / 

### /. Move person to fresh air. 

## Y If person is not breathing, 

### give artificial respiration, call 911 or 

### preferably 

### possible. an ambulance I 

### then mouth-to-mouth, 

### if /' Call a poison control center or doctor for further**tr~~thent** 

### advice. /IF ON SKIN OR CLOTHING: 

# ..... •• 

## • •• • 

# ... /,/ Take off contaminated clothing. ••••••• /- Rinse skin immediately with plenty of water for 

## ls-·2b mirnl<t.-es.

### ~' ,Call a poison control center or doctor for

### treatm~e.:**ad~te~~** 

# ______IT IN EYES: •• •• :.:



# . ..... 

# ... 

# J. Hold eye open and rinse slowly and gently Wl.th**w.2i1;,~F** 

### for**~5-20** 

### minutes. 

# .

# ... '. Remove contact lenses, if present, after the first 5 mifi'Ates, 

### then continue rinsing eye. :•••• -.' Call a poison control center or doctor for treatment**ad~ic~**

### . IF SWALLOWED:



### ,. Call a poison control center or doctor immediately for treatment advice
. • Have person sip a glass of water if able to swallow.

___ • Do not induce vomiting unless told to do so by the poison control center or doctor
. • Do not give anything by mouth to an unconscious person. EPA Reg. No. 51036-**~ET** 

### CONTENTS:**~EPA** 

### Est. No. XXXX-XXX-XXX**~~** 

### Manufactured By: MICRO FLO COMNPANY LLC 

### P.O. BOX 772099 MEMPHIS, TN 

### 38117

20

# •
• PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMALS / 

### /CAUTION. Harmful if swallowed, inhaled, or absorbed through the skin. Avoid breathing dust. Avoid contact with skin, eyes, and clothing. Do not contaminate food or feedstuffs. EMERGENCY TELEPHONE NUMBERS: 

### (800) 424-9300 (CHEMTREC, transportation and spills) (800) 900-4000 (Poison Control Center, human health) (800) 345-4735 (ASPCA, animal health) "

### DIRECTIONS FOR USE**~It** 

### is a violation of Federal law to use this product in a manner inconsistent with its labeling. 

## / / Labeling for products formulated from this product must conform to that which is currently registered with the U.S. Environmental Protection Agency.

# ~ly for formulation into a defoliant, 

# ft. Terrestrial Food Crop: Cotton

# ,< for the following**uS~A.**

/ 

## /'3. Uses for which U.S. EPA has accepted citations of data that the formulator of registration. Uses 

## u.s. for 

### EPA experimental requirements. purposes that the 

### has

are 

### /ENVIRONMENTAL HAZARDS 

## • • 

### •••• 

## ., 

# . 

# . , 

# . · ., requir®6.data and/or submitted;n**f>l~Drt**



### in 

### •••••• •

### ••• 

### • •

•• • ••• 

### • 

## •• cdmb-:tiance·· with •••••• • •••• 

### • •

•••• 

# ., . •• • • ••

### ~o not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or public waters unless this product is specifically identified and addressed in an NPDES permit. Do not discharge effluent containing this product to sewer systems without previously notifying the sewage treatment plant authority. For guidance, contact your State Water Board or Regional Office of the EPA. /'·STORAGE AND DISPOSAL

.....·-/60 

### not contaminate water, food, or feed by 

### storage or disposal.



## ?TORAGE: Store product in original other pesticides, fertilizer, food or container feed. only, away from

2 21

# •
• " 

### /'PESTICIDE DISPOSAL: Do not contaminate water, food or feed by



### , storage or disposal. Wastes resulting from the use of this product may be disposed of on site or at an approved waste 

### disposal facility
. ...----co'i'nAINER DISPOSAL: 

### Completely empty liner by shaking and tapping 

### sides and bottom to loosen clinging particles. Empty residue into manufacturing equipment. Then dispose of liner in a 

### sanitary landfill or by incineration 

### if allowed by 

### state and local authorities. If drum is contaminated and cannot be reused, dispose of in the same manner.**~DO** 

## NOT REUSE EMPTY CONTAINER ------"NOTICE OF WARRANTY**~Micro** 

### Flo Company will 

## not be responsible 

## for losses 

## or damages 

### resulting from the use of this product in any manner not specifically recommended by Micro Flo Company. User assumes all risks associated with such non-recommended use. /Micro Flo Company warrants that this product conforms to the**~** 

### chemical description on the label thereof and is reasonably fit

for purposes stated on such label only when used in accIMraance with directions under normal use conditions. It is impossible to eliminate all risks inherently associated with use**or·.~his** 

### product. •••••• • 

## • •• • • •••• 

# y/ MICRO FLO COMPANY MAKES NO ,_ WARRANTIES OF**MERCH1W~ILlm'i.·** 

### OR FITNESS FOR A PARTICULAR l?URPUSK' NOR ANY OTHER EXPRESS-·OR**I~~:!\.ED** 

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# o Restricted 4.,:.Company/Product {Name) PM' Thidiazuron Technical 23 5. Nl'lmtI and Address of Applicant (IncJud. ZIP Cod., 

### 6. Expedited Reveiw. In accordance with FIFRA Section 3{cH3) 

### Micro Flo Company LLC (bWt, my product is similat ot identical in composition andlabeling 

### P.O. box 772099 to: 

### Memphis, TN 38117 EPA Reg. No. 

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### • • •••• MorrisGaskins 

### Jan. 8,2003 

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# MICRO~ 

# FLO**1,"~**..

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# COMPANY
FAX (4 

### pages) 

### 1-703-308-1825 

### January 8, 2003


### Mr. Marcel Howard (Team 23) 

## Registration Division Office of Pesticide Programs (7504C) 

### Crystal Mall 2, Room 258 1921 

## Jefferson Davis Highway 

### Arlington, VA 22202
RE: Thidiazuron Technical EPA File Symbol Sl036-UNE
Dear Mr. Howard, The attached submission is a revised Data Matrix (internal and 

### public record) for the above referenced application in response to our telephone discussion today. Please call if 

### you have any questions. 

## Regards,

Morris Gaskins 

### Manager of Registrations 901-432-5119 morris.gaskins@microflocompany.com



### •••••• • 

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# • • Form Approved OMS No. 2070-0060 I 

### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 401 M Street, S.W. WASHINGTON, DC 

### 20460 Paperwork Reduction kJ: Notice: The public reporting burden forthis collection ofinformation is estimated toaverage 0.25 hours per response for registration activities and 0.25 hours per response for reregistration and special review actiWies, including time for reading the instructions and completing the necessaryforms. Send comments regarding the burden estimate or any otheraspectofthis collection ofinformation, including suggestions for reducing the burden to: Director, OPPE Information t-1anagement Division (2137) U.S. Environmental Protection**Agency,~91** 

### MStreet, S.W., Washington, DC 20460. Do 

### notsend the form tothis address. 

### OATAMATRIX Date: January8, 2003 EPA RegNo.,F;>. Symbol 

### 51036-UNE Page 1 of 1 Appllcant's/Registrant's Name &.Address: Micro Flo Company Product: 

### P.O. Box 772099 Memphis, TN 38117 THIDIA2URON TECHNICAL Ingredient: Thidiazuron 05 # 

### 51707-55-2 Guideline Reference Number 

### l GuidelineStudy Name ( MRID 

### Number (Submitter 

## !status 

## ! Note 830 Group A 

# I Proouct Identity, Comp:>sition and Analysis 

# I Micro Flo Co. llC 

# ISubmitted with appl. 

# I830 Group B Physical/Chemical Properties 

# IMicro Flo Co. lLC -I-=.ubmitted**~ith** appl. 

### GENERIC DATA CITE ALL cmAll CITE All CITE All CITE All cmAll**~** 

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### Morris Gaskins Date

### ~**~ ~**  

### Manager of Registrations 1/8/03 EPA Form 8570-35 (9-97) ElectronIC and aper versionS available. Submitonly Paper Vision_ Agency Internal Use Copy

### ---- 

# • • Form Approved OMB No. 2070-0060 

### UNITED STATES ENVIRONMENTAL PROTEcnONAGENCY 401 M Street, S.W. WASHINGTON, DC 20460 Paperwork Reduction k.t. Notice: The public reporting burden forthis collection ofinformation is estimated to average 0.25 hours per response for r€9istration activities and 0.25 hours per responsefor reregistration 

### and special review acti'vities, including time for rea:ling the instructions and completing the necessaryforms. 

### Send comments r€9arding the burden estimate or anyother aspectofthis collection ofinformation, iocluding suggestions for reducing the burden 

### to: Director, OPPE Information Management Division (2137) U.s. Environmental Protection Agency, 

### 401 MStreet, S.W., Washington, OC 20460. Do notsend the form tothis address. 

### DATA MATRIX Date: January 

### 8, 2003 EPA Reg No./File Symbol 

### 51036-UNE Page 1 of 1 Applicant's/Reglsttant's Name &.Address: Micro Flo Company Product: 

### P.O. Box 

### 772099 Memphis, TN 38117 

### THIOIAZURON TECHNICAL Ingredient: Thidiazuron CAS 

### # 51707-55-2 Guideline Reference Number \ GuidelineStudy Name l MRID Number Submitter Status \ Note Micro Flo Co. LLC Submitted with appl. Micro Flo Co. LLC Submitted with appl.

Uniroyal Chemical 

### Co. PAY**Nor~Am** Chemical 

### Co. PAY Spray DriftTask Force PAY Agricultural**Re~Entry**Task Force PAY Aventis CropScience USA PAY Ourdcor Residential Exposure Task PAY 

### Force 

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# /1cn-t).f: • • • ••• •••• Name and Title: Morris Gaskins Date 

### • • 

## • • • N Manager of Registrations 1/8/03 

# '" "',.,,, 

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# •
• CHEMICAL CHEMICAL NAME 120301 Thidiazuron (ANSI) 

### COMPANY# 000264 AVENTIS CROPSCIENCE USA LP

, DATA TYPES' 2 TW. ALEXANDER DRIVE BOX 12014 EU AT EC FW EF 

### OTRESEARCH TRIANGLE PARK NC XX 27709 COMPANY# 000400 CROMPTON MANUFACTURING COMPANY, INC.

, DATA TYPES '74 AMITY RD EU AT EC FW 

### EF OT BETHANY CT

XX XX 06524 COMPANY# 051036 MICRO-FLO COMPANY LLC

, DATA TYPES 'BOX 772099 EU AT EC FW EF OT MEMPHIS TN

XX XX38117 

### COMPANY# 066607 SPRAY DRIFTTASK FORCE MCKENNA & 

### CUNEO LLP 

## * DATA TYPES'" 1900 K STREET, NW ELi AT EC FW EF OT \V

### ASHINGTON DC 

### XX 20006 COMPANY# 071754 BEVERIDGE & 

### DIAMOND, Pc. AGENT FOR OUTDOORRESIDENTIAL EXPOSURE

, DATA TYPES 

# * 1350 I STREET, N.W. EU AT EC FW EF OTWASHINGTON DC XX 20005 COMPANY# 071755 BEVERIDGE & 

### DIAMOND, Pc. AGENT FOR AGRICULTURAL RE-ENTRY TASK FO

, DATA TYPES' 1350 I STREET, N.\V. EU AT EC FIV EF 

### OT IV

### ASHINGTON DC XX 20005

27

# •
• Date: August 19.2002 SUBJECT FROM:

TO: Product Chemistry Review ofThidiazuron Technical Shyam B. Mathur, Ph.D Product Chemistry Team Technical Review Branch/RD (7505C) Joanne Miller/ Marcel Howard, PM 23 Herbicide Branch 

### I RD (7505C) DP BARCODE: 0283364 EPA REG. NO.: 51036-UNE REGISTRANT: Micro-Flo Company, llC USE: Herbicide INTRODUCTION The registrant has submitted product chemistry data to support the registration of technical Thidiazuron herbicide produced in the facility located at The productchemistry data have been submitted under MRID Nos. 456019-01 thru 456019-04. SUMMARY OF FINDINGS: 1. The registrant has submitted the Confidential Statement offormula for basic formulation (dated 01-16-02) for Thidiazuron technical. The nominal concentration (98.3%) ofthe AI agrees with the product label claim. The product chemistry data submitted corresponding to guideline reference 830.1550 (Product identity & Composition), and 830.1750 (Certified limits) satisfy the data requirements of40CFR§158.155 and 158.175 respectively. 2. The product chemistry data submitted corresponding to guideline reference 830.1600 (Description of material used to produce the product) satisfy the data requirements of40CFR§ 158.160. The registrant has provided the product specifications data on all the starting materials used forthe production ofthis herbicide. 3. The product chemistry data submitted corresponding to guideline reference 830.1620 (Description of production process) satisfy the data requirements for40CFR§158.162

. 4. The productchemistry data submitted corresponding toguideline reference 830.1670 (Discussion on the formation ofimpurities)satisfy the data requirements for40CFR§158.167. 5. The data were submitted corresponding the guideline reference 830.1700 (Preliminary analysis) satisfy the data requirements of40CFR§158.170. The Thidiazuron contentwas determined by HPlC method, with UVdetector operating at 290 nm . The separation was performed on a Supelco LC-8 DB, 25 cm x 4.6 mm. 5 um column. The method wasvalidated for accuracy, linearity, and precision. 6. The data submitted corresponding the guideline reference 830.1800 (Enforcement Analytical method) satisfy the data requirements of40CFR§158.180. The HPlC method(UV, 290 nm) was used for the AI and the impurities. The method was validated for accuracy, linearity, and precision. 1. The product chemistry data submitted corresponding to guideline reference 830 Series Subgroup B (Physical/Chemical properties)for the technical produced at satisfy the data requirements of 40CFR 158.190.

28

# •
• ---------------------

BARCOOE:D283364; Reg. No

..51036*UNE PRODUCT: Thidiazuron Technical CONCLUSIONS: TheTRS hasreviewedtheproductchemistrydatasubmittedforThidiazuron Technical, producedatthe facility by Micro-Flo, Co., and has concluded that: 1. All the productchemistry data submitted correspondingto830 Series SubgroupA and Subgroup 8 satisfy the data requirements of40CFR§158.155 to 158.190 and are acceptable, exceptfor the solubility ofthe AI in the organic solvents. 2. The registrant has provided the solubility of the Thidiazuron technical in water, but did not provide information of its solubility in organic salvenls. The applicant must provide this information. 3. The CSF for basic formulation(dated 01-16-02) is filled out correctly and completely. The nominal concentration oflheAI concurswiththe productlabelclaim nominal concentration. It is in compliancewith PR Notice 91-2. The CSF for basic formulation is acceptable

.



### 29w 

### o 

# •

BARCODE:D283364; Reg. No.: 51036-UNE PRODUCT: Thidiazuron Technical 830.1550. ProduC1ldentity: (MRID No. 456019-02) 

### Common Name: Thidiazuron Technical
Chemical Name. IUPAC: 1-phenyl-3-(1,2,3-thiadiazoJ-5-yl)urea CAS; N-phenyl-N'-1.2,3-thiadiazol-5-yl urea CAS No.: 51707-55-2 PC Code No.: 120301 Empirical formula: 

### Cg 

### Ha N.l OS Molecular Weight: 

### 220.25 Structural formula: 

# Q 0 !IN 

# I )l**~-,\~** aNN S 

## H H 

# •

# •
• ATIACHMENT II REVIEWOF PRODUCT CHEMISTRY, OPPTS 830 SERIES

Chemical Name (IUPAC. ANSI, etc.) IUPAC: 1-phenyl-3-(1.2.3·thiadiazol-5-yl)urea CAS: N-phenyl-N'-1,2,3-thiadiazol-S·yl urea Chemical Number (CAS; PC Code) CAS No. 51707-55-2 PC Code:104801 Registration/Symbol No. S1036-UNE Type of Product (T, MP, EP) 98.3% TGAII MP DP Barcode 0283364 

### Reviewer --'S"'hLya"'m-"-'S",.::M"'a"th"u"r
_________ , _____ _ Branch Chief -=D"e"b"-or"a"'h-'M"c"C"'a"II'---
________ -'-
_____ _

Table l' Manufacturing and Impurity Data for the Thldiazuron Technical GLN Requirement MRIO Status' Details and/or Oeficiency' 830.1550 Product Identity and 456019-02 Y The product label claim is 98 3% concurs with composlt'lon (CSF) the nominal concentration of the AI In the CSF (dated 01.16·02), Certified limits are within standard certified tlmlts 830 t600 Descnption ofmaterlats used 4560t9-02 Y The product specification sheets(MSDS} for alt to produce product the startln materiats have been provided 830 t620 Description of production 4560t9·02 Y The registrant has provided detailed process information about the synthesis of the technical The amounts of each starting material and conditions underwhich the reaction were performed are provided. 830.t670 Discussion offorma\lon of 4560t9-02 Y The registrant has provided reqUIred impurities information on the rormation of Impurities Tho mechanism s for the formation of impurities dunng different stages of the prodUCtion orocess have been submitted 830 t700**Pre~minary** analysis 456019-03 Y Registrant has provided 5 batch analysis for TGAI produced at the facility. The HPLC method was used. The analytical method was validated for linearit ,accuracy and precision 830 t750 Certified limits 4560t9-02 Y The certified limits for the TGAI were Within the (CSFr standard certified limits The limitswere verified b 5 batch anal sis 830.1800 Enforcement analytical 4560t9-03 Y HPLC method was used to quantitate the AI method UV detector at 290 nm The method validated for accuracy, lineanty, & precISIOn

t A"Acceptable: N '" Unacceptable (see Deficiency), NfA " Not Apptlcable

, Refer to CSI Appendix A for details.



### 31Table 2 Physical and Chemical Properties f the Thidiazuron Technical 'See Note for acceptance condition 

### GLN Requirement MRID Status' Result' or Deficiency 830.6302 Color 456019·04 Y Light greenish-yellow 830.6303 Physical state " " y Powdery solid 830.6304 Odor " " y No detectable odor 830.6313 Stability to normal and " " y The TS was found to be stable at RT and al SOC. elevated temperatures. Did flot show any changes when brought In contact metals, and metal ions With 

### eu & Zn and corresponding sulfates The HPLC methodwas used to determine the concentration of the AI 8306314 OXldationlredvctiQn 

### NA chemical incompatibility 

# • 8306315 Flammability 

### NA 

### 830.631 Explodability 

## NA 6 8306317 Storage stability 456019·04 I One year study IS in proQress 830,6319 MiSCibility 

### NA 830.6320 Corrosion characterisll I I Siudy is progress along wilh one year slorage stabllt 8307000 

### ,H 456019-04 Y 564 8307050 UVNislble absorption 456019-04 Y See Note t 830,7100 Viscosity 

### NA 8307200 Melting pOint! 4560t9-04 y 209 9C to 210 4C Melting range 

# • 8307220 BOiling point! 

### NA Boihno. ranae 830.7300 Densityl 4560t9-04 Y 045glce or 28 Ibslcu fI relative densityl bulk denSity 830,7370 DIssociation constants 4560t9-04 Y pKa '" 8,86 in water 830.7550 Partition coefficient 456019-04 Y Kolw"'59 @ pH:::73 (n-octanot/water), shakeflask method 8307840 Water solubility 4560t9-04 U 31,0 ppm at 2SC column elullon method, Data are not provided for solubility In organic shake fiask method solvents 8307950 Vapor pressure 456019-04 Y 4 x to(-9) Pa at 25C

, A'" Acceptable; N '" Unacceptable (see Deficiency); NIA '" Not applicable**~** For example, "brown" lor 830 6302. "t5S" C" for 830.7200, A' '" The data are acceptable onl ifthe registrant will provUje information on the methods used to determine these properties,



### 32**~----~~--~~~~~~~~~~~~~~~---'**w w Note 1 830 7050. UVNisible 

### Iili I. max Neutral 286.4 

### nm 228.4 nm Acidic 287.6 nm 223.4 nm BasIc 

### 329.0 nm 257,4 nm 

# • •

Molar coefficient (tog e) 

### 9.75 9.37 

### 8.89 8.82 10.18



### 9.60

### Pages 34-39 *Manufacturing process information may be entitled to confidential treatment*

# •
• UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIOES ANO



### 27/AUG/2002 MEMORANDUM Subject: Name of Pesticide Product: EPA Reg. No./File Symbol: Thidiazuron Technical 51036-UNE

From:

To: DP Barcode: 0283425 Case No: 071504 PC Code: 120301 Eugenia McAndrew, Biologist

# E tV, Technical Review Branch ) , 

### V'v Registration Division (7505C)

### ~ \. 

### Marcel Howard, PM Team 23 Herbicide Branch Registration Division (7505C) Applicant: Micro Flo Company P.O. Box 772099 

### Memphis, TN 38117

FORMULATION FROM LABEL: Active Ingredient(s}: 

### 120301 Thidiazuron Inert Ingredient(s): Total: TOXIC SUBSTANCES



### % by wt. 98.30



### 100.00%

ACTION REQUESTED: PM requests review ofacute toxicity data for Thidiazuron Technical EPA File Symbol, 51036-UNE.



### 40

# •
• BACKGROUND: Micro FloCompany has submitted a six packofacutetoxicitystudies in support 

### ofregistrationofThidiazuronTechnical, EPAFile SymbolS1036 M

### UNE. Thestudieswereassigned MRIDnumbers456019 M

### 05to-10. The studieswere conducted at Stillmeadow, tnc., Sugar Land, Texas. 

### RECOMMENDATIONS: The six studies have been reviewed and are classified as acceptable. The acute toxicity profile for Thidiazuron Technical, EPA File Symbol 51036 M UNE, is as follows: acute oraltoxicity IV Acceptable MRID45601905 

### acute dermaltoxicity IV Acceptable MRID45601906 acute inhalation toxicity IV Acceptable MRID 45601907 primary eye irritation IV Acceptable MRID45601908 primary skin irritation IV Acceptable MRID 45601909 dermal sensitization Negative Acceptable MRID45601910
LABELING: Based on the toxicity profile above, the following are the precautionary and first aid statements forthis product as obtainedfrom the Label Review System.


### PROOUCTID

### #: 051036-00402 

### PRODUCT NAME: Thidiazuron Technical 

### PRECAUTIONARYSTATEMENTS 

### Hazards

## to HUmansand DomesticAnimals: SIGNALWORD: 

### CAIJ1l0N FirstAid: No statements are required. Registrant may use category 1 M3 

### statements•



### 2 41

# •
• ....... - ..

### _._-_

.. 

### _._._------,

DATA EVALUATION RECORD
STUDYTYPE: ACUTE ORAL TOXICITY TESTING (870.1100 formerly §81-1) 

### Product Manager: 23 Reviewer: Eugenia McAndrew TEST MATERIAL PURITY: Thidiazuron Technical: 98.15% aj. CITATION: Kuhn, 

### J. (2001) Thidiazuron Technical; acute oral toxicity in rats. Stillmeadow, Inc., Sugar Land, Texas. Laboratory Report Nurnber6646-01. December27, 2001. MRID 45601905. Unpublished. SPONSOR: Micro Flo Company, c/o SciReg, Inc., 12733 Director's Loop, Woodbridge, VA 22192 

### EXECUTIVE SUMMARY: In an acute oral toxicity study, five young adult albino SpragueDawley rats/sex (Weight: 263-279 9 males; 173-1909 females; Source: TexasAnimal 

### Specialties, Humble, TX) were given a single oral dose of Thidiazuron Technical (Lot. No. TDZ20010918: 98.15% a.l.: light yellow powder) al5050 

### mg/kg (limit dose). Thetest substancewas mixed with acetone to produce a 30% 

### wlv concentration, An individual dose was calculated foreach animal based on its fasted body weight and administered by gavage at a volume of 16,8 mUkg

.Animals were observed forclinical signs oftoxicity and mortality for 14 days post dosing. Individual bosyweights were recordedjust priorto dosing and on days 7 and 14, orat the time ofdeath. Necropsies were performed on all animals. Oral LO" Males = 

### > 5050 

### mg/kg (observed): Oral LO" Females = 

### > 5050 

### mg/kg (observed) Thidiazuron Technical is classified as Toxicity Category IV based on the observed LDso values in both sexes, One male died on day 2; all other animals survived and gained weight during the study

. Clinical signs noted included activitydecrease, ataxia, diarrhea, decreased defecation, loss of hind limb coordination. Ocular discharge, polyuria, respiratory chirp, splayed legs, small/dark feces, sensitivitytotouch and withdrawn testes. The survivors recovered from these symptoms by day 7. At necropsy, the animal that died on test revealedtesteswithdrawn, lungs bright red with dark blotches, liver dark, gas and tan slurry in stomach and hard yellow substance in small intestine. Threefemales that survived to studytermination had mottled lungs. This study is classified as Acceptable (870.1100) and satisfiesthe guideline requirementforan acute oral study in the rat. COMPLIANCE: Signed and dated GLP, QualityAssurance and Data Confidentiality statements were provided.

3 

### 42

# •
• RESULTS: Number ofDeaths/NumberTested Dosage (mg/kg) 

### Males Females 

### Combined 

### 5050 1/5 0/5 1/10 OBSERVATIONS: One male died on day 2; all otheranimals survived and gained weight during the study. Clinical signs noted included activity decrease, ataxia, diarrhea, decreased defecation, loss of hind limb coordination. Oculardischarge, polyuria, respiratory chirp, splayed legs, small/dark feces, sensitivity to touch and withdrawn testes. The survivors recovered from these symptoms byday 7. GROSS NECROPSY: The gross necropsy on the animal that died on test revealed testes 

### withdrawn, lungs bright red 

### with dark blotches, liver dark, gas and tan slurry in stomach and hard yenow substance in small intestine. Three females thatsurvived to study termination had mottled lungs

.

4 

### 43

# •
• DATA EVALUATION RECORD
STUDY TYPE: ACUTE DERMAL TOXICITY TESTING (870.1200 formerly §81-2) 

### Product Manager: 23 Reviewer: Eugenia McAndrew TEST MATERIAL PURITY: Thldiazuron Technical; 98.15% a.L CITATION: Kuhn, J. (2001) Thidiazuron Technical; acute dermal toxicity in rabbits. Stillmeadow, Inc., Sugar Land, Texas. Laboratory Report Number**6647~01.** 

### December 27,2001. MRID 45601906. Unpublished. 

### SPONSOR: Micro Flo Company, clo SciReg, Inc" 12733 Director's Loop, Woodbridge, VA 22192 

### EXECUTIVE SUMMARY: In an acute dermal toxicity study, five New Zealand White albino rabbits/sex (Weight: 2.150-2.475 kg males; 2.000-2.475 kg females: Source: Ray Nichols Rabbitry, Lumberton, TX) were dermally exposed to a single application ofThidiazuron Technical (Lot. No. TDZ20010918; 98.15% a.i.; lightyellow powder) at 5050 mg/kg (limit dose) for 

### 24 hours. Each dose was moistened with 0.66 mL ofvehicle (80% ethanol and 20% deionized water) per 1 g of test material and was evenly applied to approximately 10% ofthe total body surface area. Animals were observed for clinical signs oftoxicity and mortality three times on the day ofdosing and once dailyfor 14days. Individual body weightswere recorded just prior to dosing and on days 7 and 14. Observations fordermal irritation were made 60 minutes after removal ofwrappings and on days4,7,11 and 14. Necropsies were performed on all animals. Dermal LD50 Males 

## => 

### 5050 mg/kg 

### (observed); Dermal LD50 Females

# => 5050 mg/kg (observed) Thidiazuron Technical is classified as Toxicity Category IV based on the observed LDso values in both sexes. All animals survived and gained weightduring the study. The only clinical sign observed was softfeces on the day of dosing. Dermal irritation was presentat all dose sites on day 1 and at one dose site on day4. Necropsy after 14 days revealed mottled lungs in 

### 7/10 animals. This study is classified as Acceptable (870.1200) and satisfies the guideline requirement for an acute dermal study in the rabbit. COMPLIANCE: Signed and dated GLP, Quality Assurance and Data Confidentiality statements were provided.

5 

### 44

# •
• RESULTS: Numberof Deaths/NumberTested Dosage (mg/kg) 

### Males Females Combined 

### 5050 0/5 0/5 0/10 OBSERVATIONS: All animals survived and gained weight during the study. The only clinical sign observed was soft feces on the day of dosing. Dermal irritation was present at all dose sites on day 1 and at one dose site on day 4. 

### GROSS NECROPSY: Necropsy after 14 days revealed mottled lungs in 7/10 animals

.

6 

### 45

# •
• DATA EVALUATION RECORD
STUDY TYPE: ACUTE INHALATION TOXICITY TESTING (870.1300formerly §81-3) 

### Product Manager: 23 Reviewer: Eugenia McAndrew TEST MATERIAL PURITY: Thidiazuron Technical; 98.15% a.i. CITATION: Carter, L. (2001) Thidiazuron Technical; acute inhalation toxicity in rats. 

### Stillmeadow, Inc., Sugar Land, Texas. Laboratory Report Number 6648·01. December 27, 2001. MRID45601907. Unpublished. SPONSOR: Micro Flo Company, 

### clo SciReg, Inc., 12733 Directors Loop. Woodbridge, VA 22192 

### EXECUTIVE SUMMARY; In an acute inhalation toxicity study. five young adult SpragueDawley rats/sex (Weight: 256-325 9 males; 182-2209 females; Source: Texas Animal Specialties, Humble, IX)were exposed by nose only inhalation to Thidiazuron Technical (Lot No. TDZ20010918; 98.15% a.i.; light yellow powder) at 2.40 mgfLfor4 hours. The test substancewas generated as an aerosol. All animals were observed for clinical signs oftoxicity and mortality during the exposure and for 14 days post exposure. Individual body weightswere recordedjust priorto the inhalation exposure and on days 7 and 14. Necropsies were performed on all animals. Inhalation LCso Males

# = > 

### 2.40 mg/L (observed); Inhalation LCso Females

# => 

### 2.40 mg/L (observed) Thidiazuron Technical is classified as Toxicity Category IV based on the observed LCso values in both sexes. All animals survived and gained weight during the study. Clinical signs including piloerection, activitydecrease and red crust around the eyes were noted immediately after removal from the exposure chamber. All animals recovered from these symptoms by day 2. The gravimetric chamber concentration was 2.40 mg/L. The average mass median aerodynamic diameterwas 2.6 j.1m with a geometric standard deviation of4.7. Necropsy after 14 days revealed no gross abnormalities. This study is classified as Acceptable (870.1300) and satisfiesthe guideline requirement for an acute inhalation study in the rat. COMPLIANCE: Signed and dated GLP. Quality Assurance and Data Confidentiality statements were provided.

7 46

# •
• RESULTS: ExposureConcentration 

### Number of Deaths/NumberTested 

### mglL (Gravimetrically Determined) 

### Males Females Combined 

### 2.40 015 015 0110

ChamberAtmosphere 

### Exposure concentration MMAD GSD 

### 2.40 rng/L 

### 2.6 urn 

### 4.7

Chamber Environmene 

### ChamberVolume 500 L Airflow 187 LPM Temperature 71°F 

### Relative HumidJ.tY**60~64%**
II 

### Nose only OBSERVATIONS: All animals survived and gained weight during the study. Clinical signs including piloerection, activity decrease, and red crust around the eyes were noted immediately after removal from the exposure chamber. All animals recovered from these symptoms 

### by day 

### 2. GROSS NECROPSY: Necropsy after 14days revealed no gross abnormalities.



### 8 

### 47**~.** _____________________________ ---.J

# •
• DATA EVALUATION RECORD
STUDY TYPE: PRIMARY EYE IRRITATION TESTING (870.2400 formerly §81-4) 

### Product Manager: 23 Reviewer: Eugenia McAndrew 

### TEST MATERIAL PURITY: Thidiazuron Technical; 98.15% a.i. CITATION: Kuhn, J. (2001) Thidiazuron Technical; acute eye irritation in rabbits. Stillmeadow, Inc., Sugar Land, Texas. Laboratory Report**Number6649~01.** 

### December 18, 2001. MRID 

### 45601908. Unpublished. SPONSOR: Micro Flo Company, clo SciReg, Inc., 12733 Director's Loop, Woodbridge, VA 22192 EXECUTIVE SUMMARY: In a primary eye irritation study, 0.1 mL by volume (0.040 g) of Thidiazuron Technical (Lot. No. TDZ20010918; 98.15% a.i.; light yellow powder) was placed 

### into the conjunctival sac ofthe right eye of six New Zealand White albino rabbits (Source: Ray Nichols Rabbitry, Lumberton, TX). All animals were observed for ocular irritation at 1, 24, 48 and 72 hours post-instillation. Thidiazuron Technical is classified as Toxicity Category IV. Conjunctivitis (redness) was noted in one eye at the one-hour observation. No positive effects were noted at 24 hours. This study is classified as Acceptable (870.2400) and satisfies the guideline requirementfor a primary eye irritation study in the rabbit. COMPLIANCE: Signed and dated GLP, Quality Assurance and Data Confidentiality statements were provided

.

9 

### 48

# •
• RESULTS: 

### Number I 

### tested Observations 

### Hours 

### 1 

## 24 48 72 Unwashed eyes 

### I" 

### 0/6 0/6 0/6 0/6 Iritis 

### 0/6 0/6 0/6 0/6 

## 1(',
.

Redness" 

### 1/6 0/6 0/6 0/6 

### 0/6 0/6 0/6 0/6

# ~r more Icyuhcd to be 

### 0/6 0/6 0/6 0/6 i OBSERVATIONS: Conjunctivitis (redness) was noted in one eye at the**one~hour** observation. 

### No positive effects were noted at 24 hours.

10 

### 49 

## l

# •
• DATA EVALUATION RECORD
STUDYTYPE: PRIMARY DERMAL IRRITATION TESTING (870.2500 formerly §81-5) Product Manager: 23 Reviewer: Eugenia McAndrew 

### TEST MATERIAL PURITY: Thidiazuron Technical; 98.15% a.i. CITATION: Kuhn, 

### J. (2001) Thidiazuron Technical; acute dermal irritation in rabbits. Stillmeadow, Inc., Sugar Land, Texas. Laboratory Report Number**6650~01.** 

### December 18, 2001. MRID45601909. Unpublished. SPONSOR: Micro Flo Company, c/o SciReg, Inc., 12733 Director's Loop, Woodbridge, VA 22192 EXECUTIVE SUMMARY: In a primary skin irritation study, six NewZealand White albino 

### rabbits (Source: Ray Nichols Rabbitry, Lumberton, TX) were dermally exposed toThidiazuron Technical (Lot No. TDZ20010918; 98.15% a./.; light yellow powder) for4 hours. On day 0, 500 mg oftest substance moistened with OAmL of80% ethanol was applied to each testsite and covered with a single 6 cm2 

### surgical gauze patch. Animals were observed 1, 24, 48 and 72 hours after patch removal. Thidiazuron Technical is classified as Toxicity Category IVbased on the resolution ofdermal irritation by 72 hours. Primary Dermal Irritation Index (POll) :::: 0.25 One hour after patch removal, very slight erythema was noted at all six dose sites. By 24 hours, all siteswere free ofdermal irritation. This study is classified as Acceptable (870.2500) and satisfiesthe guideline requirement for an primary skin irritation study in the rabbit. COMPLIANCE: Signed and dated GLP, Quality Assurance and Data Confidentiality statements were provided. RESULTS: Primary Dermal Irritation Index (PDII)**~** 

### 025 OBSERVATIONS: One hour after patch removal, very slight erythema was noted at all six dose sites. By 24 hours, all sites were free ofdermal irritation.

11 

### 50

# •
• DATA EVALUATION RECORD
STUDY TYPE: DERMAL SENSITIZATION TESTING (870.2600 formerly §81-6) 

### Product Manager: 23 Reviewer: Eugenia McAndrew TEST MATERIAL PURITY: Thidiazuron Technical; 98.15% a.i. 

### CITATION: Kuhn, 

### J. (2001) Thidiazuron Technical; skin sensitization in guinea pigs. Stillmeadow, Inc., Sugar Land, Texas. Laboratory Report Number6651-01. January 24,2002. MRID45601910. Unpublished. 

### SPONSOR: Micro Flo Company, 

### clo SciReg, Inc., 12733 Director's Loop, Woodbridge, VA 22192 EXECUTIVE SUMMARY: In a dermal sensitization study conducted with Thidiazuron Technical (Lot. No. TDZ20010918: 98.15% a.i.: light yellow powder), 30 young adult male and female Hartley albinoguinea pigs (Source: Charles River Laboratories, Wilmington, MA)weretested 

### using a modifICation ofthe Buehler method. Preliminary testing wasconducted with four animals to determine the correct concentrations for induction and challenge. Twenty test animals were induced with three applications (six hours/exposure, once per weekforthree weeks) of400 mg oftest substance moistenedwith 0.3mL of80% ethanol. Ten naive control animals weretreated once weekly with 0.3 mL of80% ethanol. On day 29, after resting fortwo weeks, 400 mg oftest substance moistened with 0.3mL ofacetone (highest non-irritating concentration) was applied to the twentytest guinea pigs and to the ten naive control guinea pigs for a six-hour challenge exposure. Reactionswere scored 24 hours after each treatment and 48 hours afterthe first induction and challenge. A positive control study using 1-Chloro-2, 4-0initrobenzene (ONCB) was conducted within six months ofthe main studyto validatethe test system. Thidiazuron Technical is classified as a non-sensitizer based on the results ofthis study

. No dermal irritation was noted at any ofthetest sites during the induction phase. The study report states that HObservations for 10 ofthe 20test animals were not recorded at 48 hours afterthe initial induction treatment." This deviation did not affectthe outcome ofthe study. Following the challenge, nodermal irritation was noted at any ofthe test animal or naive control animal sites. Based on these results, thetest substance is not considered to be a contact sensitizer. The positive response observed in the ONCB study validates the test system used in this study. This study is classified asAcceptable (870.2600) and satisfies the guideline requirement foran dermal sensitization study in the guinea pig. COMPLIANCE: Signed and dated GLP, Quality Assurance and Data Confidentiality statements were provided.



### 12 51

# •
• PROCEDURE: 

### In a dermal sensitization study conducted with Thidiazuron Technical (Lot. No. TOZ20010918; 98.15% a3.; light yellow powder), 30 young adult male and female Hartley albino guinea pigs (Source: Charles River Laboratories, Wilmington, MA)weretested using a 

### modification ofthe Buehler method. Preliminary testing was conducted with four animals to determine the correct concentrations for induction and challenge. Twenty test animals were inducedwiththree applications (six hours/exposure, once perweek forthree weeks) of400 mg 

### oftest substance moistened with O.3mL of80% ethanol. Ten naive control animals were treated once weekly with 0.3 mL of 80% ethanol. On day 29, after resting for two weeks, 400 mg of test substance moistened with 0.3mL ofacetone (highest non-irritating concentration) was applied to the twenty test guinea pigs and to the ten naive control guinea pigs for a six-hour challenge exposure. Reactions were scored 24 hours after each treatment and48 hours after the first induction and challenge. A positive control study using 1-Chloro-2, 4-0initrobenzene (ONCB) was conducted within six months ofthe main study to validate thetest system.
RESUL

### T5: No dermal irritation was noted at any ofthe test sites during the induction phase. The study report states that uObservations for 10 ofthe 20 test animalswere not recorded at 48 hours afterthe initial induction treatment: This deviation did not affect the outcome ofthe study. Following the challenge, no dermal irritation was noted at any ofthetestanimal or naive control animal sites. Based on these results, the test substance is not considered to be a contact sensitizer. The positive response observed in the ONCB study validates the test system used in this study

.



### 13 

### 52 

## -------------------------------'

### ACUTE TOX ONE-LINERS 1. DP BARCODE: D283425 2. PC CODE: 120301 

### 3. CURRENT DATE: 

### 27/AUG/2002 4. TEST MATERIAL: Thidiazuron Technical (Lot. No, 10Z20010918; 98.15% a.i.; light yellow powder) 

### Study/Species/Lab 

### Tox. Core MRID 

### Results Cat. Grade Study

### # IDate Acute oral toxicity/rat 45601905 

### LDso > 

### 5050 mg/kg (males IV A Stillmeadow, Inc. 

### females combined) 

### 6646-01/12-27-01 

# • Acute dermal toxicitylrabbit 45601906 

### LDso > 

### 5050 mg/kg (males IV A Stillmeadow, Inc. 

### females combined) 

### 6647-01/12-27-01
Acute inhalation toxicity/rat 

### 45601907 LC50 > 

### 2.40 

### mg/L (males 

### IV A Stillmeadow, Inc. 

### females combined) 

### 6648-01/12-27-01 Primary eye irritation/rabbit 45601908 Minima! irritant IV A Stillmeadow, Inc. 

### 6649-01/12-18-01 Primary dermal irritation/rabbit 45601909 PDII = 

### 0.25 IV A 

# • Sti!!meadow, Inc. Slight 

### irritant 

### 6650-01/12-18-01
Derma! sensitization/guinea pig 45601910**Non~sensjtizer** 

### - A Stillmeadow, Inc. 

### 6651-01/1-24-02 Core Grade Key: A =Acceptable, S = 

### Supplementary. U

# =Unacceptable, V

# = SelfValldated



### 14 53

# •
• UNITED STATES ENVIRONMENTAL PROTECTIONAGENCY 

### WASHINGTON, D.C. 20460

MICRO FLO CO. LLC P. O. BOX 772099 MEMPHIS,TN 38117 

### 2/08/2002

PRODUCTNAME: THlDIAZURON TECHNICAL COMPANY NAME: MICRO FLOCO. LLC OPP IDENTIFICATION NUMBER: 269412 EPA FILE SYMBOL: 51036-UNE EPA RECEIPT DATE: 

### 2/05/02 SUBJECT: RECEIPT OF APPLlCATION FORA NEW REGISTRATION DEAR REGISTRANT: OFnCE or PREvENTION PESTICIDES AND TOXiC suaSTANCES



### The Office ofPesticides Programshas received your application for a new registration and 

### it has passed an administrative screen for completeness. Please note that this is only a notification ofreceipt ofyour application. This is only the first step in the application process, and does NOTconstitute approval. Ifyou 

### have any questions,please contact the Insecticide Branch at 703-305-7448. 

### Sincerely,

Front End Processing Staff Information Services Branch Infonnation Resources & 

### Services Division

In!eme! Address (URL)· hnp flwY.w epa gOY RecycllXiiRllCyclable .P,intedWIth Vegetable 011 Based Inks on RecyciDd Paper !Mlnlmum SO% P05tConsUmCi conu!""!! 

### 54

# •
• SdReg, Inc, Sciellce**~IH.!**

### Regulatory**Clmsull~m~**



### Ms. JoanneMiller Document Processing Desk (APPL) Office ofPesticidePrograms (7504C) U.S. Environmental Protection Agency Room 266A, CrystalMall 2 1921 Jefferson DavisHighway Arlington, V A 22202-450I Re: New ProductRegistration

N 

### Thidiazuron Technical 

### DearMs. Milief: February5, 2002



### On behalfofMicroFlo Company, SciReg, Inc. is submittinga registration package for Thidiazuroll Technical. MicroFlo is submitting its own product chemistry and acute toxicology. and is relying on the cite-all method ofdata support for all otherrequired 

### data. Should you have anyquestions. please call.

Enclosures Sincerely.

# ;lii~/~ C-----_ 

### Frederick
. Smith 

### SeniorRegulatory Specialist

12733 Din:cHlr\ Lon!" \\'o()ubridgo.!. VA 22 192 Tek'rhoIlC: 17m)**494~6S01)** F:1C:-.ill1ilc: om)492-6600 \\'ww.SciRo.!g.cOJl) 

### 55

# •

•- ,
U.S. ENVIRONMENTAL PROTECTION AGENCY 

## Office of Pesticide Programs 

# FEB 192002

MICRO FLO CO. 

### P.O. BOX 772099 MEMPHIS, TN 381172099 Report of Analysis for Compliance with PR Notice 86-5 Thank you for your transmittal of 02/05/02. Our 

## has completed a preliminary analysis of the material. provided as follows: staff 

## The results

Your submittal was found to be in full compliance with the standards for submission of data contained in PR 

## Notice 86-5. A copy of your bibliography is enclosed, annotated with Master Record ID/s (MRIDs) assigned to 

## each document sUbmitted. Please use these numbers in all future references to these documents. Thank you for your cooperation. 

## If you have any questions concerning this data submission, please raise them with the cognizant Product Manager, to whom the data have been released
. 

### are

56

# .

# .



# •

• SdReg,Inc. ScienceandRegu!atof} Consultants 

## 456019-00

Ms. Joanne Miller Document ProcessingDesk (APPL) Office ofPesticide Programs (7504C) U.S. Environmental Protection Agency Room 266A, Crystal Mall 2 1921 Jefferson Davis Highway Arlington. VA 22202-4501 February 5, 2002

Re: New Product Registration

w 

### Thidiazuron Technica1 

# 5/GSb-UN£ DearMs. Miller: On behalfofMicro Flo Company, SciReg. Inc. is submitting aregistration package for ThidiazuronTechnical. Micro Flo is submitting its 

### own product chemistry and acute toxicology, andisrelying on the citewall methodofdata support for all otherrequired data. 

### Should you have any questions. please call.

Enclosures Sincerely. 

# ;1Jirr,\J>">'>'
Frederick
. Smith 

### SeniorRegulatory Specialist

" ,**««<~ <'~** 

12733 Direclor's Loop, Woodbridge, VA 22192 Telephone: (03) -1.9-1.-6500 Facsimile: (03) -1.92-6600 www.SciReg.com 

### , 

## , , , , " " < 

# .. ,
, " ,

,

, , 

### ,, 

### "

57

# .,



# •

• TRANSMITTALDOCUMENT



### Micro Flo Company

P.O. Box 

### 772099 Memphis. TN

### 38117 Submitter SciReg, Inc.* 12733 Director's 

### Loop 

### Woodbridge, VA 

### 22192
*SciReg. Inc. is the authorized agent for Micro Flo Company. Regulatory action in supPOrt

### ofwhich this package is submitted New Product Registration:



### Thidiazuron Technical
Transmittal Date February 

### 5, 2002
Contents 

## Vol. 1 Administrative materials Vol. 2 Summary ofthe OPPTS 830.1000 Product Properties Test Guidelines 

### 45601901 Vol. 3 Group A ProductChemistry: Product Identity and Composition, Description of 

## 45601902 Materials Used to Producethe Product, Description ofProduction Process, Discussion ofImpurities, andCertifiedLimits (OPPTS 

### 830.1550, 830.1600, 830.1620,830.1670,830.1750) Vol. 

## 4 HPLC Analysis ofThidiazuron TGAIfor PercentPurity and Approximate 

## 45601903 I Percent Impurities (OPPTS 

### 830.1700, 830.1800) Vol. 

### 5 Group

### BProduct Chemistry: Physical-ChemicalProperties (OPPTS 

### 830.6302,45601904 830.6303,830.6304,830.6313,830.7000,830.7050, 830.7200, 830.7300, •••••• Vol. 6 Vol. 7 Vol. 8 Vol. 9 

### 830.7840) •••• •• 

## • Acute OralToxicityStudyin Rats (OPPTS 

### 870.1100) 45601905 : .... Acute Dermal Toxicity Studyin Rabbits (OPPTS 

### 870.1200) 45601906.":" Acute Inhalation Toxicity Study in Rats (OPPTS 

### 870.1300) 45601907 :'::. • • 

## •• 

## • Acute Eye lnritation Studyin Rabbits (OPPTS 

### 870.2400) 456i:ii908 • Vol. 

### 10 Acute DermallnritationTest in Rabbits (OPPTS 

### 870.2500) 45601909 •::::. 

## •• • •• 

## • • •• 58

# .' **"1.**



# •

• Smith to 

### Miller February 5. 2002 Page 

### 2

Vol. ii 

### Skin Sensitization Study in Guinea Pigs (OPPTS 870,2600) 

## 45601910

CompanyOfficial: 

### Company Name: Company Contact: FrederickT. Smith SciReg, Inc. 

### FrederickT, 

### Smith (703) 494-6500

" " , 

### , 

# . .. . , '''''' , ,
< <" , , 

### '" 

### ,



# . .

"



### 59

# •**MICRO~FLO T~IWlrHw"'M'i'Rorr<:ini** 

# COMPANY

February 1, 2002 Registration Division Office of Pesticide Programs (7504C) 

## u. S. EPA Ariel Rios Bldg. 1200 Pennsylvania Avenue, NW Nashington, DC 20460
RE: 

### Thidiazuron
Dear Sirs, This letter is to formally notify the Agency authorized to represent Micro Flo Company matters related to thidiazuron. that SciReg, Inc. is in any registration
Please call if you have any questions related to this matter. Regards,

Morris Gaskins 

# 4It Manager of Registrations

•••••• 

### • •• • 

## • •••••• 

### • 

## •

•• ••••• 

### • • ••••• 

# .... • •

•••• 

### •• • •• • • •• • •

### ••• 

### • •

•••• 

### •••• • ••

•• • •

### ••• 

### • •

•••• 

## •• • 

### •• 

## • 

## • •• 530 Ook Court Drive • Suite 100 • Memphis, TN 38117 • Office: 901-432-5OCO • Fax: 901-432-5100 

### 60

# ... I_rruction. on ,..,.,..

# "'0" co**fo~.** Form A roved. OMS No. 2070-00150 

# 6

Unitod State. 

# §Registration O?P Identifier Numbor 

# &EPA Environmental Protection Agency Amendment 

# 269412 Washington, DC 20460 

### Other Application for Pesticide
- Section ( 1. Compeny/Product Numbar 2. EPA Product Manager 3. Propo.ed Clas8ificlltion 

### 51036- t{ 

### IV

## E' J. Miller

## ~None 

# o Ro.lricted 4. Company/Product (Name' 

# PM' Thidiazuron Technical 23 5. Namo and Addr ••• of Applicant (Include ZIP Ccd.) 

### S. Expedited Review. In accordance with FIFRA Section 31cH3) 

### Micro Flo Co. LLC lbHil, my productis similar or identical in compositron and labeling 

### P.O. Box 

### 772099 to: 

### Merrphis, TN 38117 EPA Reg. No. 

# D Ch(l(;kifthis fs • now IJddrf}$.$ Product Name 

### Section
- II 

# 0 Amendment

- Explain below. 

# 0 Fino! printed labalt: in r.cponG' to 

# • 0 Agency lette, dated RII$ubmlnion In rDuponSII to Agllncylatter del&d -Me Too" Applicetion. 

# 0 Notification· Explttin balow. 

# [] Other· explain below. 

### Explanation: Un additional pegela) it necassery. IFor IOction I and SectionII.) 

### Initial application to register.

Section
- III 1. Mllterh:d T!1;' Product Will Bo Pockoged In: Child·Relilililtent Packaging Unit Packaging Waler Soluble Packeging 2. Type of Contairn.r 

# W"'· W'" B'0' 

# §M".

X No X No No Pleatic GIOBa e;;;catfon must If ·Yee" No. per If -Vos" No.pIH Paper Unit Peckeging wgt. contain" Pockoge wgt container X Olher ISpecify) 

### fiber drum besubmfttod I 3. locotion of Not Contonts Inlonnotion 4. Sinisi Reteil Containor 5. locotion of Lebo! Directions



## [] 

# o Container**~** DnLabel 

# """I 50 Kq On LaboUng accompanying product S. Mannor in Which Lobel i.Affix&d to Product 

# :x:: lithograph 

# 0 Othor Popar**~IUed** Stenciix:l

### Section
- IV 

## •••• I. Contect Point (Camplets irflfflS directty billow for identificsrfon ofindividual ro b. contscfed, ifnlltcessery, ro procs&S rhis spp'i't:lt'Ion.J Namo Titlo Telephone I{o. '!.N:lt!de A,.o Code) 

### Morris Gaskins Manager of Registrations • ,9QI.)432-5= 

### • • • Certification 

## ••••••**6~** P,te.Applicotion I coTtily that th" ststamanlS Ihavo mado on this form and aU attachments thorato ere tf\lO, occureto end comPw:. Roceivod 

## • ••• lacknowledge that any knowingly lolso or misloading stalamont m&ybe p!Jnishable by fine or**imprisonme~W**•• 

### •••1sC:amped) both undar t1Pplicable low. 

### • • ••••• 

## • 2. Signoture 

# /1vv-f; /1./-, 3. Title 

## •••• • •



## •••• 

## /0' p 

### Manager 

## of Registrations 

## ., • • 

## • • 

## • •• 4. TYI,.d Nama 

# lis 5. Dote

# 2-)}>~ Morris Gaski 61 EPA Form 8570-1 IRev. 8-94) ProVlou, edlbOnt ore ob,oleto.PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS PAPERWQRK REDUCTION ACT NOTICE: Public reporting burden for this collection of informetion;$ e&timoted to eller"l1o 0.85 hour per re!>ponse, including tirnlll for roviewing**instructlO~fching** existingdoUil sources, gethering end maintaining tho daw Medad, and complating end reviowing the collection of information. Send**c~1')t$** regardingthe burden &stimeto or ony other upect of this collection of information, including sugg.,rtionll for reducing this burden, to Ch,of, Informntion Policy Brench, 12136), U.S. Environment".! Protection Ag,,"cy, 40t M Street, SW, W8shinqton, DC 20460. INSTRUCTIONSi Thili form is tobe used for ell applications for new rogisttation, end use reregistration, emendment, IlIsubmilulion, to epplicetiol1l for notiftcations, finel printed laboling, raregistration, etc. In ordarto ptocess on application for 8 now registration 3ubmitted on thi3 form, tho f<»lol'ting l'IUIteri61 mutt aceompanythe eppIieation: t. Cartifiootion with**RfJl~pwt** to Citotion of DatolEPA Form 857().29). IIf Mt exemptw by 40 CFR 152.I:I1lb) 14)1: 2. Confidential Stlrtomont ofFormula (EPA Form S57().4j; 3.**Fon-nul~tor'.** Exemption SUltlHT!lIInt IEPA Form 8570·27); 4, Five copla. of draftlabeling; 5. ThtN

# oopi., of .nv data IlUbmittod; 6. Authori:etion letter where epplic8blo; 7.**Mtltric~'** whore applicable. Soominien ofLabeling- Leboling should fiat be submitted in the fom"! of draft labels with el1l.lPpilcotionll for new**regi~tretion.** Such drlllt labelll maybo in the form of typad lab&! texton a.sx 11 inch psper for eubmillsion or 0 mookup of W" proposad 10b&l.lfpreper"d for mookup, it should be comnructadin a wey es to focHitate MOtage in on 8.5 x 11 inch file. Mockup labels significantly smaller than 8.5 x 11 inches ghould bl! mount0d on 8.5 x 11 inch paplH fOf 3ubmission. Submission of O

..t.. - Dotl! submittod in support of thi::: epplicotion must bll submitted in "ccordllnco with PR Notice 86-5. 

# • SPECIFIC INSTRUCTIONS: PIIIII&e rud the instructions li&t(ld below**befor~** complatinu thiG application. Fimt determine th" typ" of regietrJltion ootion, listad in Block A, for which you are submitting thiG opplication_ For applications: ::ubmintrd in connection with New Registration IIctions, Sections 1. III, end IV mustbe completed by tho applicant. For applicstions submitted in connuction with amllrnj(ld reregistration actions, rosubmiuionc, notificotions, reregistrations:, etc., Sections 1. !I, IIInd IV must be cemp/etod by the oppUcant. Il\ocl(A - Ch"ck the appropriate ection for which you am Ilubmitting this form. SECTION 1- Thi3 section must be completed, as epplicabl€t,for 611 rogistretion eetions. 1. CompenylProduet Number -Insert your Compony Numbat, if one hllll boon ossianod by EPA.**Thi~** number m"y have btton IIssignoo to you**o~** a bJl3ic registrant, II distributor, or os an estebli.:hment. If your prodUct is ragi=ter,d, insort tha Product Numbar. 2. EPA ProductManager· 11 known, fin in tho ntune and PM number ot the EPA Product Menager. 3. PropO$$d Clu"lficllltien· Specifythe ptopoeed claceificlltion of this product. 4. Prodtlct Heme· Enter the complets product nama ef thie pesticide 0$ it will appear on the hlb!tl. The nome must be IIpecific to thia product ollly. Duplication of namell is. notpormittod Mnong products of the same company. 00 not include enybrand name or campeny liM dll3igmltioM. 5. Namo aodAddnlCG of Applicant

- Tho oeme of tho firm or per30n end address IIhownin your application is tho person or firm to whwn the rl'lglstration will bl'l ill1.lued. If yOl-l1llf1'l Gcting in behnlf of enother party, you mu;.t lIubmit authorizetion from thet porty to ect for thllm in rl'l{,)hmation metttHe. An "Pplicant not radding in tha United StMes mlJ1.It h>:lve an eutltori::od agent residing in tho Unitod St>:ltoe to ect for them in nil rogistration m>:lUer3. ThO name end complete mailing address of wch an**ag~nt** must tlccompenythis application. 6. ExpeditedRovlaw· flFflA section 3 Icl :3 18) provide" for expedited taview ofapplicutions for registration, or tmlendmants to !')xisting rll{listtati. tlult ere 3imilar or identic&! to otm.r pntieide ptoducts that are outtently registerod with the EPA. In orderfor your application tob(l tJliglbl(l fo expedited roviaw, you mustprovido us with th(l EPA Re(fistretion Number end product nlllne of thoproduct yOl-l believo is !limiler to or idantic"'! your product. The product mustba eimilor or idantic&l in both formulation end laulliad Utos. 

### SECTION II**~** Thill saction mullt ba oomplotoo for $II applicationo submitted to II/llf:)'nd tho togistration only of 1'1 currently rogilltorod product IAmendment), for e rnubmieeiQn in reoponse to on AgoncyhItter, for notifications to tho Agoncy, for the IIubmission of fin$l printod lab&!ing, for rarl'lgistrllltion and for eny othar oction thet portain, to a !l:peeiflc**EPA-reQI~tered** priXfuct. This section Is notto ba usod for 0 MW oppliclltlon for regittretion.

- -- 1. Sub}oct o(submitsion • Chock the appliceble block and provide the Agoncylettot doto If approptiete. Provide 0 brisf oxplenation of the purposels) fot tho submission, liuch as**~thl'l** oddition ofa cite, post orerop**(specifvl~;** "IIITIend the Confidential Stetement of Formule by
..."; "reregistration submission";**;&:~e"4118b&l** rovi9ion ofuse directions." Attach II 3(1psrate pege if odditionm spec$' I; neoded
. 

### •••• SECTION 1I11Pnkllgtno and Container Informotionl

- This Section mut:t be completed for rill opplications submittod in connection with naw rGgicttatkin or**~ie.blo:m,endments.** 1. Typo ofPeckaging· Check**tiI'''~Nlpriate** block if your product will bl'l peckaged in the indiceted pockoging typos. Indicate the 3i::.,p'tho**indi~utJ** p'::keu and number per retllil contolner. 2. Type of**Jt.t~W""f·** lroQ",."'.t¥PG of eontain81 In whichptoduct will ba metkotoo. 3. location of N\t.C5wventa

-**11'tIj,j~.** the locetion of the not content' lnformotion for your product. 4. Sizelsi of

## Retf**.~ttinef·** 

### SeacjfJ'.the netcontents af all rOUl!1 eontainetc for your prodUct. 5. lo
... tfon of Un Dif-eti_

-**~nd'i"tG** tho location of the use dlrectiol1$ for yourproduct. 6. Mal\laf In whichkt.b.! is afflx.1

### to"produe1 • Indicated thO' mothod ptoductlabel i= ettachod to totO'il contei'nu
. •••• 

## • • SECTION IV ICo·nUc' Paint)

- ThiD Sflction must be complatod for oil applicetions for Regi;trfltion Ilctions, i.e
.. new products ragistretien, ralllJbmi
.. lon, "",*"'0G,• '.rogistretion, otc. 

# .. . 1·5. Solf-oxplenetory. 6. EPA U

.. OniV.Fo , No.

,

## .......... UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

.

# '"

. 

# Iss:: I**~** 

# , 401 MStreet, S.W.



# - WASHINGTON, D.C. 20460 Paperwork Reduction Act Notice: The public reporting burden for this collection of inlonnatior. IS estimated to average 1.25 hour.:; per 

# , lind 0.25 hours perresponse for reregiStration and special**~view** activities. inclUding time for reading the instructions and completing the**necellSa~, f~~E**  Sen' comments regarding burden estimate or any other aspect ofthis collection of information, including suggestions for reducing Ihe burden to: Director, Information Management Division (2 (37), U.S. Environmental Protection Agency. 401 M Street, S.w.. INashington, DC 20460. Do no! send the completed form to this address. Certificationwith Respectto Citation of Data Applicant'slRegisttanfs Name, Address, and Telephone Number 

### Micro Flo Co. LLe ::PA Registration Number/File Symbol

. P.O. Box TN >0' n 51,



## .**~ct~t,1** i and/or representative test compound(s) Date 

# ,.1../; /.,

General Use Pattem(s) (list all those claimed forthis product using 40 CFR Part 158) Thi"i. 

# ", NOTE: Ifyourproduct is a 100% repackaging of anotherpurchased EPA'registere<l product labeled for all the same uses on yourlabel, you do not need to this form. You must submit the Formulator's Exemption Statement (EPA Form 8570-27).

Iam responding to a Data-Call·ln Notice. and have included with this form a list ofcompanies sen! offers ofcompensation (Ihe Data Matrrx form should be used forthis purpose).

SECTION I: METHOD OF DATA SUPPORT (Check one method only) 

# tJ I am using the dte-all method ofsupport, and have included with this form 

# 0 I am using the se!ectille method ofsupport (ordte-aB option a liSt ofcompanies sent offers ofcompens3tion (the Data Matrixform underthe**~lecti've** method), and have included with this 101m a should be used for this purpose). HSt ofdata requirements (the Data Matrtx form must be 

# "''''I. SECTION It: GENERAL OFFER TO PAY [ReqUired ifusmg the cite-all method orwhen using the cite-all option under the selective method to satisfy one ormore data requirements] 

# EJ I hereby offerand agree to pay compensation, to other persons,**w~h** regard to the approval ofthis application, to the extent required by FIFRA

. SECTION III: CERTIFICATION

# ~certify that th'ls appHC0100n for registration, this form for

# rere~l"l$tration, Q( th'l$ DattrCalf.ln response 'IS supported by all data

. . I

. for registration, the form for reregistration, orthe Data-Cali-In response. In addition, ifthe cite-all option or dte-all option**:i'i~Section** I. this application is supported by aU data In the Agency's files thlllt (t) concern the properties or effects ofthis productoran identicat or**~ s,~!!** **~roduct.** Of one or more ofthe ingredients in this product and (2) is a type ofdata thatwould be reqUIred to be submitted underthe data the dateofapproval ofthis application ifthe application soughtthe initial regtstratbn of a product ofidentical or smilarcompooman and 

# ,_. the' I certify that foreach exclusive use study cited in support ofthis regIStration or reregistration, thill I am the onglnal data submitter or that I i written permission ofthe original data submitterto cite that study. I certify that foreach study cited in support ofthis registration or reregistration that is not an exclusive use study. either: (a) I.M!l1b.Original data submitter; (b) I have obtained the permission ofthe original data submitterto use the study in support ofthis application: (c) all periods ofellgibility for compensation have expired furthe study: (d) the study is in Ihe public literalure: or (e) I have notified in writing Ihe company that subm*1td tl'ti! study and have offered (I)to pay compoosation to the extent required by sections 3(c)(t)(F) and/or 3fc)(2)(B) of FIFRA: and (ii) to commence**negotiat~nl\llol!etermine** the amount and terms ofcompensation, if any, tobe paid forthe use ofthe study. 

# ....... • • 

## • • Icertify that in all instances where an offer of compensation is required, COPieS ofall offers to pay compensatfon**and·eviden()£>·~'trQjr** delivery in accordancewith sections 3(c)(1)(F) and/or 3(cl(2)(B) of FIFRA am available al'ld will be submitted to the Agency upon**f~Mt!** Should' M'il"!:o produce such

. evidence to theAgency upon request, I understand that the Agency may inruate action to deny, cancel or**~uspend** the registr8tion of**~~** in conformity wi FIFRA. ...... ••• 

## • • ••••• 

## • t certify thatthe st:ltements I have made on this fonn and all attachments to tt arc true, accurate, and comptete. I ac\iModgo thatany knowingly "hllse or misleading statement may be punishable by fine or imprisonmentor both underapplicable law. 

## • • •••• Signature 

# /'l1 .--.-.z 

# A ,,- Date 

# /i"**~d** qr Prrnted**N~me** and**;'H~··** • 

### rrlS Gaskins 

# , ,f
. <- 

# ",."" 

# / "'Pee",m,,,, " 

# ,5",,,,,,,', , 63

# • •
f-orrn Approved OMS No 2070 0060 

### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 401 M Street, S.W. WASHINGTON, DC 20460 

# 'c

-- ------- ----- ---------- ---------------- ------ -------------- -__ ___ __ _______ __

Pape!work Reduction Act NotICe: The public repoitlng burden for UllS collection r:i Information IS estimated to average 0.25 hours per response for registration actlvltles and 0.25 hours per restXJnse for reregistration and special reView actIVities, including time for reading the Instructions and completing the necessary forms. Send comments regarding the burden estimate or any other aspect of this collection ofinformation, including suggestions for redudng the burden to: Director, OPPE Information Management Division (2137) U.s. Environmental Protection ,_Agen0', 401 M**Str_~t, S.:~:!,Washington,**  DC 2.9460. Do notsend**th~** form tothis address. 

### DATA MATRIX 

# ;1-/,

# Ii>;;' - Date: EPA Reg No,/FiteSymbol 

### 51036-appl. Page 1 of 1 

### Appticant's/Regiirant's Name & Address: 

### Micro Flo Compan-y--- Product: 

### P.O. Box 

### 772099 Memphis, TN 38117 THIDIAZURON TECHNICAL Ingredient: Thidiazuron CAS # 51707"55-2 Guideline Reference Number GuidelineStudy Name MRID Number Submitter Status Note 830 Group A Product Identity, Composition and AnalYSis Micro Flo 

### Co. LLC Submitted with app!. 830 Group B Physical/Chemical Properties Micro Flo 

### Co. llC Submitted 

### with app/. 

### GENERIC DATA CITE All. Uniroyal Chemical 

### Co. PAY CITE All. Nor-Am Chemical 

### Co. PAY CITE All. 

### SpayDriftTask. Force 

### PAY CITE ALL Agricultural Re-Entry Task Force 

### PAY CITE All. Aventis OupSdence USA 

### PAY 

### 870.1100 Acute oral toxicity 

### IM-'**~'n ~n** **LL~** 

# ",

.tb appl 

### Acute dermal toxicity 

### • 

## • •••**~'n ~n** **LL~** 

### SUbm. with apol. 

### 870.1200 

## • • • • • 

## •• ••**~'n ~n** **LL~**

### ~ubm. 

### with appl. 

### 870.1300 Acute inhalation toxicity.." "" 

### • 

## ••• 870.2400 Eye irritation Micro Flo Co. 

### LLC**~ubm.** 

### with appl. 

### ••• • • 

## • '" 

### • b"hm 

## ''" 

# -, 870.2500 

### In 

# . , . 

# ,h" ••• • • • 

## ••• " -I,Ln 

## • • • • 

## ••• •• • 

## •• • • 6ubm. with aool. Dermal sensitization ••• 

### • • • 

## • • • l'licro Flo Co• 

### LLC .Jl2Q. 

### 2600
___ ••• 

## • • • NameandTItle: 

### Morris Gaskins Date fignature

# /VJ~~ 

# .. Manager of Registrations

# _~,.JAJ-.**--.~**.. _------------ EPA Form 8570-35 (9-97) Electroni( and Paper versions a¢ilable. 'Submit only PaperVision.

. Agency Internal Use Copy 

# o**5a~M.-J;;~/~3**

# • • Form Approved OMB No. 2070-0060 

### UNITED STATES ENVIRONMENTAL PROTECITON AGENCY 401 M Street, S.W. WASHINGTON, DC 20460 Paperwork ReductIOn Act Notice response for reregistration and 

## hepublic reporting burden 

## for**thl's-collectK;;;-(;r~for;;:;a-b-o~i iSeSi-,~;';ted~'toa~e~age** 

## 0 .is-Ilours-

## pe"f'respOn'sefor7egii;:.3tiO'n

## aCtivities

## a'nd'o.2S-h-ourspe-r-- :ial review activities, Indudlng time for reading the instructions and completing the necessary forms. Send comments regarding the burden estimate or any other aspect ofthis colledio:**.J~gen9:,!,_'!Q!:..!'!...~~~1.~W.~.,~,**f information, including suggestions for reducing the burden to: Olrector, QPPE Information Management Division (2137) U.s. Environmental Protection 19too,**~**__.?g460.**~0't** send theform to this address
. 

### -



### - "-"-



# -**~~~-~---------'"** lAddress: 

### Micro Flo Company**--~-** -- Date: 

# b,. _",j**~** Applicant's/Regi ant:.i. 

### P.O. 

### Box 772099 

### 5 # 

### 51707-55-2 Ingredient: Thidiazuron CAS Guidelrne Reference Numbe

# , IGuideline study Name 

### DATA MATRIX

-------, 

### Memphis, TN 38117



### - MRID Number



### • • • ••• 

## • • • • 

### ••• •• 

## • • 

## • • • 

## •• • 

## • • • •

• •••••
••• • • • 

# ..

# . • ••• 

## • • • • 

## • • • • • • • 

## • • • • • • • • • 

### •••••• • 

## • • ••• 

## • •• • ••• -.,._--_. 

## • - 

# ... •**~** Signature 

## ':A'"ocm8576C 

## 35(9'97)'Elewon"""dPo-",,,Q"'ble. Submit only PaperVision.**"'~-----------,---** EPA Reg No./FileSymbol 

### 51036-appl. iPagelofl 

### .- Product: 

### THIDIAZURON TECHNICAL

Submitter 

### Status Note Micro Flo Co. LLC Submitted with appl. Micro Flo Co. LLC Submitted with appl.

Uniroyal Chemical Co. 

### PAY**Nor~Am** Chemical Co. 

### PAY Spray Drift: Task Force 

### PAY Agricultural Re-EntryTask

### Force PAY Aventis CropSdence USA 

### PAY 

### Micro Flo Co. LLe

. ch .nnl 

### Micro Flo Co. LLe 

### subm. with appl. Micro Flo Co. LLe 

### subm. with appl. Micro Flo Co. LLe 

### subm. with appl. 

### tHcro Flo Co• LLe 

### subm with aool. 

### Micro Flo Co. LLe 

### subm. with annl. NameandTItle: Morris Gaskins 

### Da" Manager 

### of Registrations 

# i/YOLAgency Public Record Copy 

## L--__________________________ --

### Pages 66-67 - *Confidential Statements of Formula may be entitled to confidential treatment*