TRANSLATION Report on the study ofthe acute irritation/corrosion to the intactdorsal skin ofwhite rabbits based on OECD** rabbit/skin Testing facility:

Aim of the study:
Test substance No.; Name oftest substance: Stable until: Form of application: Exposure period: Number ofanimals: 

# - - Opservation period:

Responsible for correct translation:
This report consists of 6pages. 

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••• M.ethodand assessment based pn OECD Guideline (404) for Testing of Chemicals adopted May 12th, 1981. A detailed product characterization is included in the raw data
. Sheet1Results of acute skin irritation/corrosion {OECD) Sheet 2 METHOD 

### Animal species: Animal breeder: Type of cage: No. ofanimals per cage: Animal identification: Room temperature/relative humidity:

Day/night rhythm: Bedding: Diet:
Drinking water: Acclimatization period: Clipping ofthe fur: Cage made of stainless steel with wire mesh walk floor; floor area: 40 em 

## x51 em 

# I Ear tattoo (= 

### animal No.) The animals were accommodated in fully air· conditioned rooms, in which central air conditioning guaranteed a range of temperature of 20 - 24

## •c and a range of relative humidity of 30..,. 70%. There were no deviations from these specifications that would have impaired the test results. 12 h/12 h (6:00 - 18:00 hours/18:00- 6:00 hours) No bedding in the cages; sawdust in the waste trays OVATOR SOLJKANIN 4 mm; (about 130 g per animal per day) About 250 ml tap water per animal per day About 8 days before the beginning ofthe study in the skin laboratory; same housing conditions as during the study At least 15 hours before the beginning ofthe studyResults ofacute skin. irritation/corrosion (OECD) Sheet 3 Application**are<~:** Volume applied:

Application site: Removal ofthe test substance: Readings:
Negative .control: 

### 2.5 em x 

### 2
..5 em Dipping ofthe test patch into the undiluted test substance. (In the case ofan edge length of.2.5 em, apout 0.5 ml ofthetest liquid is absorbed.) Upperthird ofthe backor flank At the end qfthe exposure period with·Lutrol and Lutrol/water (1: 1) 30 - 60 minutes after removal ofthe test patches and 24 

### h,48 h, 72 

### h and 

### 8 d after the beginning ofapplication Untreated skin sites ofthe same animalResults of acute**s~in** irritation/corrosion (OECD) Sheet 4 Additional examinations:

Pathology: Storage ofthe report and.raw data:

Data input: Data control: Date of application: Mean weight (kg) male: female: After sacrifice, the animals are examined by gross pathology. Ifthere are clinical signs of necroses, these are confirmed by grosspathological examination after incision ofthe skin. (lfthere.are differences between the clinical and pathological assessments, only the latter is included In the final report.)



### 2.61 

### 3.15Results of acute skin.irritation/corrosion (OECD) .Sheet 5 Exposure period: 4 hours
Animal 1 2 3 Animal No. 0449 0482 0453 Animal weight(kg) 2.80 3.15 2.41 Sex Male Female Male
Readings Animal Intact skin Erythema Edema Signs 4h 1 2 2 ER:e/ED:e 2 2 1 ER:e/ED:e 3 2 2 ER:e/ED:e 24 h 1 3 3 ER:e/ED:e 2 3 2 ER:e/ED:e 3 2 2 ER:e
/ 48 h 1 3 3 ER:e/ED:e 2 3 2 ER:e/ED:e 3 2 2 ER:e 72 h 1 2 2 ER:e/ED:e 2 3 2 ER:e/ED:e 3 3 2 ER:e Bd 1 0 0 S/+ 2 1 1 S:se/+ 3 1 0 S/+Results of acute skin Irritation/corrosion (OECD) 

### Grading oferythema (ER) and edema (ED): 0 

### = no erythema or edema 1 = questionable 2 =slight 3 =marked 4 =severe
Key: h =hour d =day


### Explanation ofsigns: ED:e 

# = edema extending beyond the area ofexposure ER:e 

# = erythema extending beyond the area of exposure S =scaling S:se 

# = severe scaling 

### + =finding confirmed by gross-pathological examination Sheet 6