# REGISTRATION 66330-334 Vol.3

# Material Sent for Data Extraction
Reg #

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# _3_--':'_Lf~ 

# Descri pti 0 

# n:

______**~~e'--'re;:::,'}j.:..:~ s=--~2.-...C_+w:--,-'.:-.-·**  _______ _ 

# IZI Material(s) Sent to Data Extraction Contractors:

New Stamped Label Dated 4/::2..0/ II



# o Notification Dated

____ _ 

# yr New CSF(s) Dated

____ _ 

# o Other:

_________ _


# Decision 

# #:

__ 3_f1_3_I_G---,-I

__



# Other Action/Comments:

Attach this coversheet to the top of the material or jacket. It must be well organized and clipped together, NOT STAPLED. Then give the material with this coversheet to staff in the Information Services Center (Room S-4900).


# Reviewer: Mindy Ondish

Phone: 703-605-0723 Division: RD/PM Team 25
Date:

____________**y---'-/~~i~/~I~I** 

# ______________ _

## (**$~€.OS"i,** 

### U.S. ENVIRONMENTAL PROTECTION AGENCY EPA Registration Date of Issuance: 

# i 

# Q**~** Office of Pesticide Programs Number: Registration Division (7504P)

# \~IU) Ariel Rios Building /.0, 

# 2 6 2011 66330-334 Ii ii'

### ~LPM!¢ 1200 Pennsylvania Ave., NW Washington, D.C. 20460



### NOTICE OF PESTICIDE: Term of Issuance: 

### Unconditional 

## L Registration 

## l Reregistration Name of Pesticide Product:

(under FIFRA, as amended) 

### Thidiazuron 4 SC
Name and Address of Registrant (include ZIP Code): 

### Arysta LifeScience North America, LLC 15401 Weston Parkway, Suite 150 Cary, NC 27513

Note: Changes in labeling differing in substance from that accepted in connection with this registration must be sUbmitted to and accepted by the Registration Divisi6n"priodo use of the label in commerce. In any correspondence on this product'always referlo the· above EPA registration number, ',,'

On the basis of information furnished by the registrant. the above named pesticide is hereby registered/reregistered under the Federal InsectiCide, Fungicide and Rodenticide Act. Registration is in no way to be construed as an endorsement or recommendation of this product by the Agency. In order to protect health and the environment. the Administrator, on his motion, may at any time suspend or cancel the registration of a pesticide in accordance with the Act. The acceptance of any name in connection with the registration of a product under this Act is not to be construed as giving the registrant a right to exclusive use of the name or to Ils use if it has been covered by others.



### EPA received a label amendment request submitted on April 20, 2011. EPA grants this request under the authority of section 3(c)(5) of the Federal Insecticide, Fungicide and Rodenticide Act, as amended. With this accepted labeling, all requirements set forth in the Reregistation Eligibility Decision (RED) for Thidiazuron have been satisfied. Therefore, EPA reregisters the product listed above. This action is taken under the authority of section 4(g)(2)(c) of the Federal Insecticide, Fungicide, and Rodenticide Act, as amended. 

## Reregistration under this section does not eliminate the need for continual reassessment of pesticides. EPA may require submission of data at any time to maintain the registration of your product.

Submit one (1) copy offinal printed labeling. Amended labeling will supersede all previously accepted labels. A copy of your label stamped "Accepted" is enclosed for your records. Products shipped after twelve (12) months from the date of this Notice or the next printing of your label, whichever occurs first, must bear the new revised label.

If you have any questions regarding this Notice, please contact Mindy Ondish at (703)605-0723 or at ondish.mindy@epa.gov.

S;,,,'",e of 

## Aoo",;o,**~** Date:



### Kathryn V. Monta ue

. 

# t/;;Vv(YJ 

# V 

# {nanfj

l1PR 2 6 Product Manage 2 

# 2011 Herbicide Branch Registration Division (7505P)

EPA Form 8570·6

### (



# THIDIAZURON 4 SC

COTTON DEFOLIANT 

### For Agricultural Use Only

ACTIVE INGREDIENT: Thidiazuron (N-phenyl-N'-1 ,2,3-thiadiazol-5-ylurea)*

....................... 42.4% OTHER INGREDIENTS:

......... ...... ...... ................................. . .............................. 57.6% 

### "Not less than 4.0 Ibs. of thidiazuron per gallon TOTAL ......• 100,0%



### KEEP OUT OF REACH OF CHILDREN 

# CAUTION

- CAUCION

Si usted no entiende la etiqueta, busque a alguien para que se la explique a usted en detalle. ([fyou do not understand this**labe~** find someone to explain it to you in detail.)



### FIRST AID
IF ON SKIN 

# • Take off contaminated clothing. OR Rinse skin immediately with plenty afwater for 15-20 minutes. CLOTHING: 

## • • Call a poison control center or doctor for treatment advice.
IF IN EYES: 

# • Hold eye open and rinse slowly and gently with water for**15~20** minutes.


# • Remove contact lenses, if present, after the first 5 minutes, then continue rinsing.


## • Call a poison control center or doctor for treatment advice.
IF INHALED: 

## • Move person to fresh air.



## • If person is not breathing call 911

, or an ambulance, then give artificial respiration, preferably**mouth~to·mouth** if possible.


## • Call a poison control center or doctor for further treatment advice. IF 

## • Immediately call a poison control center or doctor for treatment advice. SWALLOWED: Do not induce vomiting unless told to do so by a poison control center or doctor. 

# •
• Have person sip a glass of water if able to swallow.


## • Do noU;:jlve an.Ytbing

### ~ mouth to an unconscious p_erson. 

### HOT LINE NUMBER EMERGENCY TELEPHONE NUMBERS: Have the product container or label with you when calling a poison control center or doctor or going for treatment. 

### FOR 24-HOUR EMERGENCY MEDICAL ASSISTANCE CALL: 1-866-303-6952 FOR CHEMICAL EMERGENCY: Spill, leak, flre, exposure, or accident call CHEMTREC**1-800-424~** 

### 9300.

SEE INSIDE (SIDE PANEL) FOR ADDITiONAL PRECAUTIONS AND USE DIRECTION S "';;;-'"

EPA Reg. No. 66330-334 EPA Est. NJ 

# 1-1. 

# 0 C EPT E 

# D

AD 081705



### NET CONTENTS:

__ _

Manufactured For: 

### ARYSTA LlFESCIENCE NORTH AMERICA, LLC 15401 Weston Parkway, Suite 150 Cary, NC 27513 

### lPC; 

# 2 6 20ir

Under tho Fod:mu lWecilclde, Pung!.olde, and Rodentlolde Ad, M Oltu!m&!d, tOI"" the pe.lJl;ielde \""\1;.;i::toroo. unool'**l'~:'k!!~** No 

# 0.Se.3. 1...\

Page 1 of9

### (

PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMALS CAUTION Harmful if swallowed, inhaled, or absorbed through the skin. Avoid breathing spray mist. Avoid contact with skin, eyes, and clothing. Do not contaminate food or feedstuffs,

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

### All 

### mixers, loaders and applicators must wear:

•**Long~sleeved** shirt

• Long pants

• Shoes and socks

• See Engineering Controls for Requirements

USER SAFETY REQUIREMENTS 

### Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry.

ENGINEERING CONTROLS STATEMENT 

### Engineering controls for Aerial Application: Enclosed cockpits Pilots must use an enclosed cockpit that meets the requirements listed in the WPS for agricultural pesticides [40 CFR 170.240(d)(6)] When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240 (d) (4-6)], the handler PPE requirements may be reduced or modified as specified in the WPS.

USER SAFETY RECOMMENDATIONS Users should:

• Wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet.

• Remove clothing/PPE immediately if pestiCide gets inside. Then wash thoroughly and put on clean clothing.

• Remove PPE immediately after handling this product. 

### As soon as possible, wash thoroughly and chanae into clean cloth ina.

ENVIRONMENTAL HAZARDS

Do not apply directly to water, or to areas where surtace water is present, or to intertidal areas below the mean high water mark. Do not contaminate water when disposing of equipment washwater or rinsate. Do not apply when weather conditions favor drift from treated areas. This product may contaminate water through drift of spray in wind. This product has a high potential for runoff for several months or more after application. Poorly draining soils and soils with shallow water tables are more prone to product runoff that contains this product. A level well-maintained vegetative buffer strip between areas to which this product is applied and surface water features such as ponds, streams, and springs will reduce the potential for contamination of water from runoff. Runoff of this product will be reduced by aVOiding applications when rainfall is forecasted to occur within 48 hours. Sound erosion control practices**w~l** reduce this product's contribution to surtace water contamination. This chemical has properties and characteristics associated with chemicals detected in ground water. Use of this chemical in areas where soils are permeable, particularly where the water table is shallow, may result in groundwater contamination.

PHYSICAL OR CHEMICAL HAZARDS This product 

### is incompatible with strong oxidizing agents such as nitrates, chlorine bleach or hydrogen peroxide.

Page2of9

### (

DIRECTIONS FOR USE



### It 

### is a violation of Federa! law to use this product in a manner inconsistent with 

### its labeling

Do not make applications of this product that may contact workers or other persons either by drift or directly. Protected handlers only are allowed in the area during application. Consult your State or Tribe agency responsible for pesticide regulations for any specific recommendation.

AGRICULTURAL USE REQUIREMENTS Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR 

### Part 170. This Standard contains requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific instructions and exceptions pertaining to the statement on this label about personal protective equipment (PPE), and restricted-entry interval. The requirements in this box only apply to uses of this product that are covered 

### by the Worker Protection Standard.

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 24 hours.

PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as soil or water, is:

• Coveralls

• Chemical-resistant gloves made of any waterproof material

• Shoes_plus socks

PRODUCT INFORMATION

THIDIAZURON 4 SC, a harvest aid compound, is used for leaf removal prior to cotton harvest. THIDIAZURON 4 SC

can be used in aircraft or ground equipment and is easily dispersed in water. Several days may pass before effects of treatment may be observed. Low temperature and other adverse conditions may require longer times and/or higher dosages for adequate defoliation. THIDIAZURON 4 SC diminishes lint staining at the time of harvest and ginning by slowing regrowth.

USE RESTRICTIONS

This product is not to 

### be applied through any type of irrigation system.

The efficacy of THIDIAZURON 4 SC will be diminished 

### if rainfall occurs within 24 hours post application.

Foliage from treated plants or gin trash is not to be fed to livestock. Do not use immature crops for feed.

Rotation to the following crops re quires the minimum of the specified periods below after the last application of THIDIAZURON 4 SC.

small grains, sorghum, corn, or root crops (except carrots, onions or sugar beets) '"

........ two (2) weeks legumes (including alfalfa) or leafy vegetables (except lettuce and spinach)

.................... two (2) months sugar beets

..................................................................................................... .four (4) months carrots, onions and spinach

.................................... '"

........................................... nine (9) months lettuce

........................ ONLY when soil has been deep-plowed (12-15 inches)

............ nine (9) months

To avoid defoliation of a nd injury to other plant species. prevent spray drift from con tacting crops other than mature cotton.

Mixtures with organophosphate products can increase non-target crop phytotoxicity. Exercise additional care when lettuce, citrus, cantaloupes or any other edible crops are adjacent to THIDIAZURON 4 SC treated fields.

Page30f9

## (

RESTRICTIONS TO LOWER SPRAY DRIFT POTENTIAL ONTO NONMTARGET CROPS

Under windy weather conditions, applications of TH1D1AZURON 4 SC may drift to nonMtarget crops. The following restrictions will help reduce drift potential:



### • If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground applications of THIDIAZURON 4 SC.

• Nozzle pressures of 20

- 30 psi are recommended.

• Do not apply this product during a temperature inversion because drift potential is high. In addition, do not apply this product 

### if the development of a temperature inversion appears likely during the application period.

• In general, a decrease in droplet size or increase in wind speed at the time of application will result in risk to nontarget organisms. Alternatively, if droplet size is coarser or wind speeds are lower, exposures due to drift would be reduced.

• Do not apply this product by ground within 100 feet or by air within 0.5 mile of lettuce.

RESTRICTIONS TO LOWER SPRAY DRIFT POTENTIAL IN THE RIO GRANDE VALLEY OF TEXAS

The following restrictions will help reduce the potential for drift:

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground applications of THIDIAZURON 4 SC. If wind speeds are less than ten (10) miles per hour, obselVe local recommendations from
your State Extension Cotton Specialist

• Nozzle pressures of 20

- 30 psi are recommended.

• Do not apply this Product during a temperature inversion because drift potential is high. In addition, do not apply this product if the development of a temperature inversion appears likely during the application period.

• In general, a decrease in droplet size or increase in wind speed at the time of application will result in risk to nontarget organisms. Altematively, if droplet size is coarser or wind speeds are lower, exposures due to drift would be reduced.

• Use the maximum nozzle orifice size that provides appropriate coverage and deposition of this product.

• CITRUS A REAS: Do not apply THIDIAZURON 4 SC by ground when citrus in flush {burst of new growth as in springtime) is within 1/2 mile downwind of the point of application. Do not apply by air when citrus in flush is within 5 miles downwind of the point of application.

TIME OF APPLICATION

THIDIAZURON 4 SC defoliant applications are to be made only on mature cotton plants when the uppermost halVestable boll is mature. Boll maturity is defined as: 1) when a boll is squeezed between thumb and finger, it does not dent; 2) when cutting a cross section with a sharp knife is difficult; 3) when seeds in cross section lack liquid within the seed coat or outer edges of seed coat are light brown; and 4) when fully developed cotyledons are present.

Make applications of THIDIAZURON 4 SC at least five (5) days prior to expected halVest date.

NOTE: The following conditions will determine adequate defoliation with THIDIAZURON 4 SC:

• Cotton is actively growing

• High relative humidity

• Cotton plant leaves are turgid and not desiccated

CONDITIONS

Under low nighttime temperatures (below 60°F), this product, when used alone, may provide less than expected defoliation and/or regrowth suppression. For best results, apply this product when overnight temperatures will exceed 60°F two to three days before and after application.

The effects of THIDIAZURON 4 SC on heat or drought stressed cotton having non-turgid leaves and extremely waxy leaf surfaces may include reduced defoliation and reduced regrowth suppression.

Page4of9

### ( 

### (

THJD!AZURON 4 SC AS A FOLLOW UP DEFOLIATION TREATMENT



### Reduced or unsatisfactory defoliation may occur when THIDIAZURON 4 SC is used as a second or follow up treatment, except when 

### fonowing a prior THIDIAZURON 4 SC or THIDIAZURON 50WP stand alone or tank mixed application with other defoliants. Also, see CONDITIONS.

CROP OIUADJUVANTS USAGE

Crop oil concentrates (COC's) or penetrating oils approved for agricultural crops have shown to improve performance under low nighttime temperatures (60 0

- 65°F) and heat or drought conditions. Follow adjuvant label recommendations for proper rates.

Adjuvant usage in the desert Southwest (i.e., Arizona and California) is recommended when applying THIDIAZURON 

### 4SC.

ATTENTION: During periods 0 f high temper ature, the use of adjuvants rna y result in the fre ezing an dlor 

### desiccation of leaves. As a re suit, the use of such compounds is not recommended during high temperature Periods.

MIXING INSTRUCTIONS

1. Fi!1 spray applicator tank with at least one half of the water to be used 2. Start agitation 3. Add the appropriate volume ofTHIDIAZURON 4 SC 4. Continue agitation and fill tank with the remainder of the water to be used 5. Agitation should continue throughout the application

TANK MIX ADJUVANTS



### To assist in defoliation perfonnance it is recommended, when using a combination of this product and organophosphate defoliants in a tank mix, that a compatibility agent or surfactant is also used. Always perfonn a small jar test for compatibility before tankMmixing.

When tankMmixing, only toleranceMexempt products (pursuant to 

### 40 CFR 

### 180.1001) are permitted for use.

Fo!1ow manufacturers label instructions of the appropriate adjuvant.

When an adjuvant is to be used with this product, Arysta recommends the use of a Chemical Producers and Distributors Association (CPDA) certified adjuvant.

Page50f9( 

## I

APPLICATION



### Use an adequate volume of water with the specified amount of THIDIAZURON 4 SC defoliant to unifonnly and completely cover leaves. For ground equipment. apply 10

- 25 gallon per acre and by air, use 3 -10 gallons per acre. Maintain agitation during application.

Do not allow mixed spray solution to stand overnight.

DOSAGE

Application Rate: Use O.1251b ai/A (4 fl oz/A). You will be able to make applications to 20-40 acres with one gallon of this product. When under low temperatures of 60 0

- 65°F, use the higher rate of 0.2 Ib ai/A (6.4 

### fI ozlA).

When defoliating rank cotton, two applications are sometimes required for adequate defoliation. Maximum of two applications, but not to exceed 0.3 Ib ai/A per year. Maximum application rate of a.3lb ai/A per year (9.6 

### fI ozlA).

For cutout and mature cotton under normal weather patterns use Thidiazuron 4 SC at 0.05 to 0.10 Ib ai/A. The 0.05 Ib rate is most effective when used in a tank mix with other cotton defoliant products.

Increased rates ofThidiazuron 4 SC above 0.10 Ib of ai/per acre may be needed to defoliate and control regrowth during periods of rank growth/high fertilizer conditions, extreme weather conditions, such as extended periods of rain and/or low temperatures (60'-65'F) and on full-season cotton varieties.

To Achieve an Application Use this Amount of Product At the Indicated Rate, One Rate of: Gallon of Product Wi!! Treat 0.07 Ib ai/A 2.3 

### fI oziA 

### 56A 0.17 Ib ai/A 5.4 

### fI oz/A 23.5A

ARIZONA ONLY: BOTIOM DEFOLIATION THIDIAZURON 4 SC can be used to help reduce bon rot and hard lock: caused by moisture retained in the canopy, by aiding improved air circulation within the cotton canopy. Base product application timing upon the latest date when application equipment will not cause significant crop damage when driving applicator through the cotton crop.

Application Rate: Use 0.051b active ingredient/acre (1.6 

### fI ozlA).

It is recommended to apply THIDIAZURON 4 SC only to the bottom 1/3 of the plant.

ARIZONA AND CALIFORNIA ONLY: PRECONDITIONING

When used as a pre-conditioner seven to ten days before application of other defoliant compounds, this product will improve the efficacy of such a defoliant application. Before use, observe all product label directions, recommendations and prohibitions on both products' labels.

Application Rate: Use 0.05-0.1 Ib active ingredient/acre (1.6-3.2 fl oz/A).

TANK MIXES OF TH!DIAZURON 4 SC AND ETHEPHON CONTAINING COMPOUNDS

Improved defoliation and improved opening of mature bolls can be achieved by tank mixing THIDIAZURON 4 SC and Ethephon 6TM or its equivalents. For best results, apply to mature cotton plants (See Application Timing section of this label). Wait until unopened bolls have reached adequate maturity so as to not affect the desired cotton yield. Certified cottonseed producers should consult seed companies as to proper boll and seed maturity requirements for their varieties. Low nighttime temperatures (if expected to be below 60°F) can reduce defoliation and decrease regrowth suppression.

Application Rate: Use 0.05-0.125 Ib active ingredient/acre (1.6-4 fl oZ/A) of THIDIAZURON 4 SC along with 1-2 Ib active ingredient/acre (32-64 fl oz/A) of Ethephon 6TM.

Page6of9/ 

# ,

Under conditions of excessive regrowth potential or expected low temperatures, use the higher rates of THIDIAZURON 4 SC. When under low temperatures of 60 c

- 65"F, use the higher rate of 0.2 Ib ai/A (SA 

### fI ozlA).

TANK MIX OF THIDIAZURON 4 SC PLUS ETHEPHON FOR DEFOLIATION ENHANCEMENT:



### To improve defoliation, you may use lower rates (high enough to promote boll opening) of Ethephon em or its equivalents tank: mixed with this product. Following such an application, Ethephon 6Th! can still be used to promote boll 

### opening. Per year, however, you may use no more than 2.0 Ib ai/acre of Ethephon 6TM 

### (approximately 42 

### fI oz of product) across all applications. Observe all product label directions, recommendations and prohibitions for Ethephon 

### 6TM,

Application Rate: Use 0.05-0.125 lb. active ingredient/acre (1.6-4 

### fl ozlA) of THIDIAZURON 4 SC along with 0.251b active ingredient/acre (32-64 

### fl ozlA) of Ethephon 6TM. If excessive regrowth or low temperatures are expected, use the higher rate of 0.2 Ib ai/A (6.4 

### fl ozlA) of THIDIAZURON 4 SC. Maximum application rate of 0.3 Ibs ai/Acre per year. Maximum of 2 applications, but not to exceed 0.3 Ibs ai/Acre per year

TANK MIX OF THIDIAZURON 4 SC WITH TRIBUFOS PRODUCTS (DEF® I FOLEX®)

When plants to be treated are subject to non-ideal conditions, such as overnight temperatures below 60"F one day previous and three days after application, 

### it is recommended to tank mix this product and DEF® 6/FOLEX® 6 EC. This combined spray solution will improve regrowth suppression and defoliation.

Make tank mix applications to mature cotton with at least 60% open bolls to achieve best activity.

RATE OF APPLICATION forTHIDIAZURON 4 SC

- TRIBUFOS TANK MIXES

THIDIAZURON 4 SC at 1.6 to 4 fluid ounces per acre 

### + DEF® 6 at 0.5

- 2.0 pints per acre.

THIDIAZURON 4 SC at 1.6 to 4 fluid ounces per acre 

### + FOLEX® 6 EC at 0.5

- 2.0 pints per acre.

If excessive regrowth is expected, use the higher rates of THIDIAZURON 4 SC.

ATTENTION: Desiccation may occur when tank mixing organophosphate defoliants and maximum rates of this product during extremely high temperatures.

When under low temperatures of 60"

- 65"F, use the higher rates of DEF® 6/FOLEX® 6 EC as specified.

For tank mix ofTHIDIAZURON 4 SC and DEF® 6/FOLEX®6 EC: Follow MIXING INSTRUCTIONS. Following the complete dispersion of THIDIAZURON 4 SC, add the required amount of DEF® 6/FOLEX® 6 EC to spray tank. Should an additional application of this tank mix be necessary, be sure to use
no more than a total of 0.125 Ib active ingredient per acre (4 

### fl ozlA) of this product.

Observe all product label directions for use, recommendations, prohibitions and tank mixing compatibility instructions for DEF®6 and FOLEX® 6 EC.

CAMERON, HIDALGO, STARR AND WILLACY COUNTIES OFTHE STATE OF TEXAS: THE USE OF A TANK MIXOFTHIS PRODUCT WITH DEF®S OR FOLEX®S EC IS PROHIBITED.

IMPORTANT CLEANOUT INSTRUCTIONS

When tank mIXing organophosphate defoliants with THIDIAZURON 4 SC, a residue may form in application equipment. This residue can best be flushed out of the spraying system by using a commercial tank cleaner when done while residue is still fresh and moist. DO NOT ALLOW EQUIPMENT TO DRY BEFORE CLEANOUT. Consult your State Extension Cotton Specialist for recommended tank deaners and cleaning procedures.

Page70fg( 

### (

Tank cleaner and water should be used immediately after application. The entire system including nozzles, booms, application tanks, sumps, pumps, and transfer lines should be flushed. Allowing the spray solution to 

### dry in the application equipment can result in residues that are more difficult to remove. Dried residues are extremely difficult 

### to remove, To remove such dried residues, 

### fill the afte cted equipment to capacity with com mercial tank cleaner solution and let it remain for 7 days. Afterwards, the equipment 

### will need to be thoroughly flushed and 

### rinsed.

Spray application equipment that has been inadequately cleaned will contain residue of TH[DIAZURON 4 SC, Such improper cleaning could lead to crop damage in later applications. Arysta assumes no liability for crop damage due to equipment that has not been properly cleaned.

STORAGE AND DISPOSAL

Do not contaminate water, food, or feed by storage or disposal.

PESTICIDE STORAGE: This product should be stored at temperatures less than 100 0 F. Should this product be subject to freezing conditions, this product should be re-mixed prior to use.

PESTICIDE DISPOSAL: Wastes resulting from the use of this product must be disposed of on site or at an approved waste disposal facility.

CONTAINER DISPOSAL: Nonrefillable container. Do not reuse or refill this container. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment

or a mix tank and drain for 10 seconds after the flow begins to drip. Fill the container 

### "X full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times. Offer for recycling, if available, or puncture and dispose of in a sanitary landfill, or by incineration, or if allowed by state and local authorities, by buming. If burned, stay out of smoke.

RETURNABLE/REFILLABLE CONTAINER: Refill this container with pesticide only. Do not reuse this container for any other purpose. Cleaning the container before final disposal is the responsibility of the person disposing of the container. Cleaning before refilling is the responsibility of the refiller. To clean the container before final disposal, empty the remaining contents from this container into application eqUipment or a mix tank. Fill the container about 10 percent full with water. Agitate vigorously or recirculate water with the pump for 2 minutes. Pour or pump rinsate into application equipment or rinsate collection system. Repeat this procedure two more times. To Return: Do not rinse container. Do not empty remaining formulated product. Do not break seals. Return intact to point of purchase. To Refill: This container can be refilled by Arysta LifeScience North America, LLC or an Arysta-authorized registered establishment. Retum this container to such a site or the point of purchase after use. Examine product packaging before refilling, checking for any type of damage, including abrasions, fractures, punctures, or damaged closure devices. Prior to transporting this container, inspect for leaks. Inspect for leaks again before and after refilling. Refilling of leaking containers is prohibited.

Page8of9

### (

Warranty and Disclaimer Statement The directions for use of this product are believed to be adequate and must be followed carefully. However, it is impossible to eliminate all risks associated with the use of this product. Such risks may arise from weather conditions, soil factors, off-Iarget movement, unconventional farming techniques, the presence of other malerials, the manner of use or application, or other unknown factors, all of which are beyond the control of Arysla LifeScience North America, LLC ("Arysla"), and can cause crop injury, injury to non-target crops or plants, ineffectiveness of the product, or other unintended consequences. All such risks shall be assumed by the

user or buyer. Arysta warrants that this product conforms to the chemical description on the label and is reasonably fit for the purposes stated in the Directions for Use, subject to the inherent risks described above, when used in accordance with the Directions for Use under normal conditions, This warranty does not extend to the use of this product contrary to label instructions or under conditions not reasonably foreseeable to Arysta, and is subject to the inherent risks described above.

TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ARYSTA DISCLAIMS ALL OTHER WA RRANTIES, EXPRESSED OR IMPLIED, INCLUDING ANY WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ARYSTA, MANUFACTURER, AND SELLER OISCL AIM AND SHALL NOT BE LIABLE FOR ANY SPECIAL, INCIDENT AL, INDIRECT, OR CONSEQUENTIAL DAMAGES RESULTING FR OM THE USE, HANDLING, APPLICATION, STOR AGE, OR DISPOS AL OF TH IS PRODUCT OR FOR DAMAGES IN THE NATURE OF PENALTIES, AND THE US ER AND BUYER WAIVE ANY RtGHT THAT THEY MAY HAVE TO SUCH DAMAGES. NO AGENT, REPRESENTATIVE ORE MPLOYEEOF ARYSTAI S AUTHORIZEDTOM AKE ANYWARRANTY,GU ARANTEEO R REPRESENTATION BEYOND THOSE CONTAINED HEREIN OR TO MODIFY THE WARRANTIES CONTAINED HEREIN.

TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, THE EXCLUSIVE REMEDY OF THE USER OR BUY ER, AND THE TOTAL LIABILITY OF ARYSTA, MANUFACTURER, ANO SELLER, SHALL BE LIMITED TO THE PURCHASE PRICE PAID, OR AT ARYSTA'S ELECTION, THE REPLACEMENT OF THE PRODUCT.

Def 

### ® is a registered trademark of Bayer Crop Science Ethephon 

### 6Th! is a trademark of Arysta LifeScience North America, LLC Folex 

### ® is a registered trademark of Amvac Chemical

Page90f9Follow Up:



### Mindy

### Thidiazuron 4 SC Labels (66330-334) HAWKINS, Alex 

### to: Mindy On dish Cc: "DYKES, Jan"

Urgent Priority. 04/20/2011 

### 09:34 AM

Here are the corrected Thidiazuron 4 SC labels (Clean and Strikeout versions) at long last. I should have
the Thidiazuron-Diuron SC (66330-344) to you by the end of the day. it is currently undergoing a few 

### last minute corrections. As 

### discussed previously, we have not added the resistance management language.

Regards,

Alex Hawkins

W. A. Hawkins, 

### Jr., Ph.D. Regulatory Manager Arysta LifeScience North America, llC 

# "111

919-678-4886/ fax: 

### 919-678-2194 066330-00334.20110413.Thidiazuron4SCcln.pdf

### ~'-i**~;**

066330-00334.20110413. Thidiazuron4SCSTK.pdf

### (

# ~ Re: FW: 66330-334 Thidiazuron 4 SC label comments 

## Cl**_~_-.=-="-,-"'** 

# __ :cM:::in;;;dLY Ondish to: HAWKINS, Alex 04/06/2011 

### 01 :35 PM



### Alex,

Thank you for getting to this quickly. In response to your questions: 

### 1) Resistance management grouping symbol can be omitted from this label if 

### it will be confusing to the

user. 2) The buffer restrictions can be removed from the Ag Use box and placed in the Restrictions sections. Ideally, the restrictions should be verbatim of what the thidiazuron RED states, so 

### fi you can change the 

### statements to match that would be best. 3) I would prefer "This product is incompatible with strong oxidizing agents such as [list example]." over the other statement you proposed.

Hope that helps, 

### Mindy

"HAWKINS, Alex" 

### MilJdY,'::,We are currently.working on making the

...

From: To: Date: Subject:

Mindy**~** 

### "HAWKINS, Alex" <Alex.HAWKINS@arystalifescience.com;> Mindy Ondish/DC/USEPAlUS@EPA 04/0512011 

### 05: t9 PM FW:**66330~334** 

### Thidiazuron 4 SC label comments 

### 04/05/201105:19:14 PM

We are currently working on making the requested corrections to the Thidiazuron 4 Sc**(66330~334)label** 

### (and the**Thidiazuron~Diuron** 

### SC label;**66330~344).** 

### Upon studying your remarks, I have a couple of comments and a question regarding the former.

First, resistance management language is not appropriate for a cotton defoliant product. Unlike conventional herbicides that are applied to control weed pests that are capable of developing resistant populations over time, defoliants are applied to mature cotton plants to aid in harvest. Weed pests

are not involved. There is no concern about resistance developing because all of the cotton will be harvested and there is no "chemical selection" for resistant individuals that could eventually lead to resistant populations. Arysta will not add resistance management language on the Thidiazuron 4 SC label.

Second, I have not studied this label before. Bill Washburn left the company at the end of May, and I inherited the cotton defoliants that he was previously responsible for. In reviewing the draft label, I note that Bill added some drift management language inside the Agricultural Use Requirements box (at the bottom). This language is a duplication of drift reduction language that appears on the next page of the label. I don't think it belongs in the Agricultural Use Requirements box, and I'd like to remove it. Is that acceptable?

Regarding your comment about Chemical or Physical Hazards, can you suggest what specific remarks might be included under this heading? I've looked at the labels of all registered thidiazuron products on PPLS, and none of them have this kind of information. Is it sufficient to add a statement such as: "This product is incompatible with strong oxidizing agents" or "Keep away from incompatible products, such as strong oxidizing agents"? I looked at the

## (

data, and there was an exothermic reaction when the product was combined with potassium permanganate. I 

### can use some help here.



### Regards,

Alex Hawkins

W. A. Hawkins, Jr., Ph.D. Regulatory Manager Arysta LifeScience North America, LLC 919-678-4886 

### I fax: 919-678-2194



### -----Original Message----- From: JANIS, Jonathan 

### Sent: Wednesday, March 16, 2011 4:34 PM To: Ondish.Mindy@epamail.epa.gov; HAWKINS, Alex Subject: RE: 66330-334 Thidiazuron 4 se label comments

Mindy, 

### Alex Hawkins handles the Thidiazuron labels for Arysta.



### I will forward this email to him.

Best regards, Jonathan

Jonathan A. Janis Regulatory Manager

Arysta LifeScience North America 

### Mobile- 919.749.1410 Office- 919.678.4917 Fax- 919.678.2182

-----Original Message----- From: Ondish.Mindy@epamail.epa.gov [mailto:Ondish.Mindy@epamail.epa.gov] Sent: Tuesday, March 15, 2011 6:14 PM To: JANIS, Jonathan Subject: 66330-334 Thidiazuron 4 SC label comments

Mr. Janis,

I could not reach Bill Washburn so I am redirecting this to your attention since you are listed as the contact email for Arysta.

After review of the draft reregistration label for the subject product, the following changes must be made:

1. Due to the importance of resistance management to a long-term

2. 

### pest-management strategy, it is suggested that resistance management grouping symbols and statements be included on the labeling as described in PR Notice 2001-5.

Change the PESTICIDE DISPOSAL phrase to "must be disposed of".

3. Add a "PHYSICAL OR CHEMICAL HAZARDS" section directly below the Environmental Hazards section and place a statement regarding the

### incompatibility of the prOduct with other chemicals (e.g. oxidizing agents) as evidenced by the Oxidation/Reduction data provided.

4. Move the GENERAL INFORMATION section on page 2, and the USE PRECAUTIONS, SPRAY DRIFT PROCEDURES, and SPRAY DRIFT PROCEDURES IN RIO GRANDE VALLEY sections on page 3 so that they are within the DIRECTION FOR USE section.

5. Change the heading from "GENERAL INFORMATION" to "PRODUCT INFORMATION 

### "

6. 

### Change the heading from "USE PRECAUTION" to "USE RESTRICTION".

7. 

### Change the heading to "RESTRICTIONS TO LOWER SPRAY DRIFT POTENTIAL

8. 

### ONTO NON-TARGET CROPS" restrictions will help Change the sentence to "The reduce drift potential:" following

Change the heading to "RESTRICTIONS TO LOWER SPRAY DRIFT POTENTIAL IN

9.

10. 

### THE RIO GRANDE VALLEY OF TEXAS". change the sentence to "The following restrictions will help reduce drift potential:" Change the last bullet to "CITRUS AREAS: Do not apply this product by 

### ground within 0.5 mile or by air within 5 miles downwind of the point of application when citrus is in flush."

Add the following restriction to both spray drift sections:

"In general, a decrease in droplet size or increase in wind speed at the time of application will result in risk to non-target organisms. Alternatively, if droplet size is coarser or wind speeds are lower,
exposures due to drift would be reduced."

Change the phrase under APPLICATION to "specified amount".

11. Under DOSAGE, change the sentence to "The 0.05 lb. rate is most effective when used in a tank mix with other cotton defoliant products. "

Please submit a revised clean copy of the label via email to my attention and feel free to contact me if you have any questions.

Thanks,

Mindy Ondish Biologist / Risk Manager Herbicide Branch (PM Team 25) Registration Division (7505P) Office of Pesticide Programs U.S. Environmental Protection Agency Phone: 703-605-0723

### (



### Date: May 18, 20 I 0

Reg. No.: 66330-334 Product Name: Thidiazuron 4 SC PM NamelNumber: Kathryn Montague, Risk Management Team 23

Primary Reviewer: Judy Loranger

# ~ .-<.-0

# ~04-;fLJ (0)9// 0 

## Secondary Reviewer: Mark 

## Perry**~**



### New label or date ofRD amended label: New, Received on 

## 2125/09

Formulation Type: Liquid



## Active Ingredient Assessed: Thidiazuronl120301

Other ai's 

## in product Name!PC code: 

## Reregistration Status or Registration Date: N/A N/A

Note to PM:

I) The Risk Management and Implementation Branch V (RMIB V) notes that the label 

## for this product does not include resistance management labeling as described in PR Notice 2001-5. The Agency encourages registrants to add the resistance management 

## grouping symbols and statements to product labels in 

## view of the importance of resistance management to a long-term pest management strategy.

2) For clarification, RMIB V suggests that the spray drift text required in the RED and 

## which appears on the label be revised to read:

''Thidiazuron products can not be 

## applied by 

## air within**~** 

## miles 

## of lettuce or within 5 miles upwind of citru_s in flush (burst of new growth, as in springtime) in the Rio Grande valley of Texas. Ground applications are restricted to no less than 100 feet
away from lettuce and no less than**~** 

## mile upwind from citrus."

Assessment can be found N:lprbllabe11066330/334

1) 

## Per the product chemistry review, physical or chemical hazards text must be added to the label.

2) Per the RED label table and Appendix A, the rate restriction text should be revised to 

## read as specified below and any conflicting text must be deleted:

"Rate restrictions under normal conditions: 

## Maximum application rate is 0.125 lbs 

## ai per acre.

I(



## Maximum application rate is 0.3 Ibs ai per acre per year. Maximum of 2 applications, but not to exceed 0.3 Ibs ai per acre per year.

Rate restrictions under variable conditions: 

## Maximum application rate is O.21bs ai per acre. Maximum application rate is 0.3 Ibs 

## ai per acre per year. Maximum of 2 applications, but not to exceed 0.3 Ibs ai per acre per year."

3) The text" The 0.5 lb rate" on the bottom of Page 6 of the label must be revised per the 

## RED to 

## read "The 0.05 Ib rate is most effective when used in a 

## tank mix 

## with other cotton defoliant products is most effective when used in a tank 

## mix with 

## other cotton defoliant products."

2

## UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, D.C. 20460

April I, 2009

MEMORANDUM:

Subject:



## From:

To:



## Applicant: EPA Reg. No.: 66330-334/ Thidiazuron 4 SC DP Barcode: 363248 Case No.: 4092

John L. 

## Dupuy Ph.D, Pathologist

# a~·**~I 3'~'-P§?17-**  Product Reregistration Branch ! 

# V Special Review and Reregistr

. on Division (7508P)

Barbara Briscoe, CRM Product Reregistration Branch Special Review and Reregistration Division (7508P)



## Arysta LifeScience North America, LLC 15401 Weston Parkway, Suite 150 Cary, NC 27513

FORMULATION FROM EPA Reg. No. 66330-334 LABEL:

Active Ingredient(s): OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES



### %bywt.



## Thidiazuron

.............. _ ..................................................................... 42.4% Other Ingredient(s):

................................................................................................. 57.6% Total 100.0%

### (



### BACKGROUND: In the 8 month response to the Thidiazuron RED, the registrant has submitted
acute toxicity studies to support the reregistration 

## of their product, EPA Reg. No. 66330-334. The 

### MRID's are as follows: 476859-01 (81-1),476859-02 (81-2), 

## 476859-03 (81-3),476859-04 (81- 

## 4),476859-05 (81-5), 

## 476859-06 (81-6). The studies were conducted by Stilhneadow, Inc. The 

### test material used in each of the 

### studies was the subject product.

RECOMMENDATIONS:



### • The acute toxicity studies submitted are acceptable to support the reregistration of 

## EPA Reg. No. 

## 66330-334.

The acute toxicity profile for EPA Reg. No. 66330-334 is currently:



### Acute Oral N 

### Acceptable
Acute Dennal 

### N 

### Acceptable 

### Acute Inhalation N Acceptable 

### Primary Eye N 

### Acceptable 

### Primary Dermal N Acceptable 

### Skin Sensitization non sensitizer Acceptable



### NOTE: The acute toxicity requirements have been satisfied for the subject product.

### (



### DATA REVIEW FOR ACUTE ORAL TOXICITY (§81-1, 870.1100)

Product Manager: Joanne Miller, 23 

### MRlD No.: 476859-01

Testing Facility: Stillmeadow Inc. Author: J. 

### Knhu

Quality Assurance (40 CFR §160.12): Included

Test Material: Thidiazuron 4 SC, beige liquid Species: Sprague-Dawley albino rat Age: young adult 

### Weight: females**~** 

### 164- 198 g Source: Texas Animal Specialties



### Conclusion: (Up and Down Method)

1. 

### LDso (mglkg): > 

### 5000 mg/kg

2. Toxicity Category: IV



### Procedure (Deviations from §81-1): none

Results: 

## Main Test Reviewer: John 

## L. Dupuy Ph.D 

### Study Completion Date: 1127/09 

### Report No.: 12580·08

Classification: Acceptable

Test Sequence 

### Auimalld Dose Level Short tenn 

### Longtenn 

### (mglkg) 

## outcome outcome I 

### 271 5.000 D D 2 272 175 S S 3 273 550 S S 4 274 1.750 S S 5 275 5.000 S S
6 

### 277 5,000 S S
7 278 5,000 S S

Observations'



# . Dose Time of Death 

## Clinical Observations mglkg 

### 5,000 117 on day 2 

## Piloerection, activity decrease, lateral recumbency

Gross Necropsy: Decedent: 

### 117 stomach filled 

## with white fluid. Survivors: 

### 617 no gross 

## abnonnalities noted.(



### DATA REVIEW FOR ACUTE DERMAL TOXICITY (§81-2, 870.1100)

Product Manager: Joanne Miller, 23 

### MRID No.: 476859-02 Reviewer: John L. 

### Dupuy Ph.D 

### Study Completion Date: 2/6/09 

### Report No.: 12581-08

Testing Facility: Stillmeadow Inc. Author: 

## J. Kuhn

Quality Assurance (40 CFR §160.12): Included



## Test Material: Thidiazuron 4 SC, beige liquid Species: Sprague-Dawley albino rat 

### Weight: males**~** 

### 296

- 326 g; females**~** 

### 175

- 204 g Age: young adult Source: Texas Animal Specialties

Summary:



### 1. 1.050 

### (mglkg): >5050 mg/kg

2. Toxicity Category: IV 

## Classification: Acceptable

Procedure (Deviations From §81-2): none

ResuJts: Reported Mortality

Dosage (mg/kg) 

## (number deaths/number tested) 

## Males Females Combined 5050 015 015 0110



## Observations: Twenty four hours prior to application of the 

## test material, the dorsal surface of 

## the 

## trunk was clipped free of hair 

## not less than 10% of the 

## total body surface area. The test material was applied neat to an intact test site, covered by 

## a 2 x 4 inch surgical gauze patch and secured with 

## non-irritating adhesive tape. The trunks were wrapped with vet wrap which was secured with non-irritating adhesive tape. After 24 hours, the wraps and pads were removed and the test sites were gently cleansed. One female lost weight during the first week and one male and female lost weight during the second week.

Gross Necropsy Findings: No observable abnonnalities were noted.

## ( (

DATA REVIEW FOR ACUTE INHALATION TOXICITY TESTING (§81-3, 870.1300)

Product Manager: Joanne Miller, 23 

## MRID No.: 476859-03 Reviewer: John L. 

### Dupuy Ph.D 

## Study Completion Date: 2/9109 

## Report No.: 12582-08

Testing Facility: Stillmeadow Inc. Author: C. 

### Younger



## Quality Assurance (40 CFR §160.12): Included

Test Material: Thidiazuron 4 SC, beige liquid Species: Sprague-Dawley albino rat 

## Weight: males**~** 

## 282

- 312 g, females**~** 

## 184

- 214 g Age: young adult Source: Texas Animal Specialties

Summary:

1. 

## LCso (mgIL): > 

## 2.33 mglL

2. MMAD:**2.4~m** 

## GSD: 6.3

3. Tox. Category: IV Classification: Acceptable

Procedure (Deviation From §81-3): None

Results: 

## Reported Mortality Exposure 

## (number deaths/number tested) Concentration Males Females



## 2.33 mg/l 015 015



## Chamber Atmosphere Dose Level mgII 

### MMAD GSD 

## 2.33**2.4~m** 

## 6.3**1.4~m** 

## 6.4 combined 

## 0110

### ( (



### Chamber Dose Level rng/l 

## Environment 2.33 

## Chamber Volume SOOL Airflow 

### 181 Lorn Temperature eCl 19.8-21.9 

## Relative Humiditv % 

### 32.1-38.1

Clinical Observations: 10110 exhibited activity decrease and piloerection from 4.5 hours through 

### day 4. All gained weight during the study.

Gross Necropsy Findings: No observable abnonnalities noted.

### (



## DATA REVIEW FOR PRIMARY EYE IRRITATION TESTING (§81-4, 870.2400)**Prod~ct** 

### Manager: Joanne Miller. 23 

### MRlD 

## No.: 476859-04



## Testing Facility: Stillmeadow, Inc. Author: J. Kuhn

Quality Assurance (40 CFR §160.12): Included

Test Material: Thidiazuron 4 SC. beige liquid 

### Dosage: 0.1 ml 

## Species: New Zealand White albino rabbit Sex: 1 male and 2 females Reviewer: John L. 

## Dupuy Ph.D 

## Study Completion Date: 1126/09 

## Report No.: 12583-08



## Weight: male**~** 

### 2.125 

## kg, females**~** 

### 2.250

- 2.350 

## kg Age: young adult Source: Nichols Rabbitry Inc.

Summary:



### Toxicity Category 

### N Classification: Acceptable

Procedure (Deviations From §81-4): none

Results



### (number "J: 

### ositive"/number tested) Observations 

## Hours Days
I 

## 24 48 72 

## Corneal Opacity 

## 0/3 0/3 0/3 0/3 Iris 

## 0/3 0/3 0/3 0/3 Conjunctivae

Redness 

## 0/3 0/3 0/3 0/3 Chemosis 

## 0/3 0/3 0/3 0/3 Discharge 

## 0/3 0/3 0/3 0/3

No ocular irritation was noted during the study.(



## DATA REVIEW FOR SKIN IRRITATION TESTING (§81-5, 870.2500)



## Product Manager: Joanne Miller, 23 MRID 

## No.: 476859-05

Testing Facility: Stillmeadow Inc. Author: J. Kuhn

Quality Assurance (40 CFR §160.12): Included



## Test Material: Thidiazuron 4 SC, beige liquid Dosage: 0.5 ml 

## Species: New Zealand White albino rabbit Age: young adult 

## Sex: 2 males; I female Reviewer: John L. 

## Dupuy Ph.D Study Completion Date: 1130109 

## Report No.: 12584-08

Weight: males**~** 

## 2.300 kg, female**~** 

## 2.350 kg 

## Source: Nichols Rabbitry Inc.

Summary:



### 1. 

## Toxicity Category: IV



## 2. Classification: Acceptable**PDII~** 

## 0.0

Procedure (Deviations From**§81~5):** 

### none

Results: Twenty four hours prior to application 

## of the test material, the dorsal area 

## of the trunk:



## was clipped free of hair 

## to expose an area of at least 8 x 8 em. The test material was applied neat
to an intact test site and covered with a 4 ply, 

### 2.5 x 2.5 em surgical gauze patch. Each patch was 

## secured with non-irritating adhesive tape. The trunks 

## were wrapped 

## with a orthopedic stockinette which was secured with strips of tape. After 4 hours, the wraps and pads were removed and the test sites were gently cleansed with tap water.

No dennal irritation was noted.

### (



### DATA REVIEW FOR DERMAL SENSITIZATION TESTING (§81-6. 870.2600)



### Product Manager: Joanne Miller, 23
MRID 

### No.: 476859-06



### Testing Facility: Stillmeadow Inc. Author: 

### J. Kuhn

Quality Assurance (40 CFR §160.12): Included

Test Material: Thidiazuron 4 SC, beige liquid Reviewer: John L. 

### Dupuy Ph.D Study Completion Date: 1130/09 

### Report No.: 12585-08



### Positive Control Material: HCA, historical control**#11950~08,** 

### 7/5/08

Species: Hartley albino guinea pig Weight: males**~** 

### 372- 438 

### g. females**~** 

### 325-406 

### g Age: young adult Source: Charles River Laboratories

Method: Buehler



### Summary:

1. This Product is a non-sensitizer



### 2. Classification: Acceptable

Procedure (Deviation From**§81~6):** 

### none

Procedure:

A group of animals were used to detennine the highest non-irritating concentration (HNIC) of the

test substance prior to the challenge dose. The HNIC for the test substance was detennined to be 100% 

### test material.

The test animals were induced 

### with 0.4 mL of 100% test material applied beneath a 4 ply, 2.5 x 2.5 em surgical gauze patch over wrapped with clear polyethylene film and secured in place with tape once weekly for 3 weeks. Twenty four and 48 hours after each induction dose the animals

were scored for irritation. Two weeks after the last induction dose, 0.4 mL of 100% test material

was used to challenge the test animals. Twenty four and 48 hours after the challenge the animals

were evaluated for sensitization.

A group often animals were used as naive controls. These animals received only the challenge doses of the test material.

### ( (



### Results: 

### During the induction phase of the study, no dermal reactions were noted for the test material induced animals.

Twenty four hours after the challenge, no dennal reactions were noted for either the test group or the naive control group.

### LABELING:

ID #: 

### 066330-00334 THIDIAZURON 4 SC

SIGNAL WORD·: CAUTION

HAZARDS TO HUMANS AND DOMESTIC ANIMALS:

Wear long sleeved shirt, long pants, shoes, and socks.



### FIRST AID:

IF SWALLOWED: Call a poison 

### control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to by a poison control center or doctor. Do not give anything by mouth to an unconscious person.



### IF ON SKIN OR CLOTHING: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for

treatment advice.

IF INHALED: Move person to fresh air. If person is not breathing, call 911 or ambulance, 

### then give artificial respiration, preferably mouth-to-mouth, ifpossible. Call a poison control center or doctor for further treatment advice.

IF IN EYES: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call

a poison control center or doctor for treatment advice.

Have the product container or label with you when calling a poison control center or doctor or going for treatment. You may also contact 1-800-xxx-xxxx for emergency medical treatment infonnation.

*Note to Label Review Team: No First Aid statements or Signal Word are required due to the toxicity categories. If the registrant wishes to include First Aid statements or Signal Word then they must be the same as listed above.



### USER SAFETY RECOMMENDATIONS:

User should wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet.

User should remove clothingIPPE immediately if pesticide gets inside. Then wash

### thoroughly and put on clean clothing.

Users should remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing.

## 1

DATE OUT: 06/MAY/2010

SUBJECT: PRODUCT CHEMISTRY REVIEW OF: TGAI [[; MUP []; EUP [X] BARCODE NO.: D376597 

### REG.IFILE SYMBOL NO.: 66330-334


### PRODUCT NAME:

### ....'cTC-hi!!!d'-'ia"'z';"ur":o~n;;4c;S"C~=-:;---:-_-C--;-;-:; ____ 

## -:-::==:-===--:c:-: COMPANY NAME: Arysta LifeScience North America, LLC ACTION CODE: 676**CONTRACTOR:_C"",SC~** 

### ___________ PROJECT CODE: PRD-56 OPII

FROM:

TO: Maria Rivera Piansay, Chemist 

# r**J~ ~~1**  Product Chemistry Team '. \j / 

### Risk Management and Implementation Branch V ! 

### Pesticide Rewevaluation Division (7508P)



### Barbara Briscoe, CRM Risk Management and Implementation Branch V 

### Pesticide Re-evaluation Division (7508P)

INTRODUCTION:

With this resubmission, Arysta LifeScience North America, LLC provided a revised Confidential Statement of Formula (CSF) for the basic formulation, dated 04/05/2010. 

### The registrant is req1iesting 

### reregistration of their product, Thidiazuron 4 SC, EPA Reg. No. 66330-334.

FINDINGS:

1. EPA Reg. No. 66330-334 is an end-use cotton defoliant, containing the active ingredient, Thidiazuron, with a label claim nominal concentration of 42.4%. The product is a harvest aid compound, used for leaf removal prior to cotton harvest. The prochlCt is for agricultural use only. The product is produced by a non-integrated system.

2. The CSF has been revised as requested in our review of 03/05/10. 

### The revision involved changing the nominal concentration of the active ingredient from 42.7% to 42.4%, to match the label and the concentration of record with the Agency. TIle CSF and the label are now in agreement and in compliance with PR Notice 91-2.

3a. The Active fngredient Statement on the draft label is now acceptable as per 40 CFR §156.10(g) and PR Notices 91 -2 and 97-6.

3b. Data are present to trigger the need for a Physical or Chemical Hazards Statement: Add the heading "Physical or Chemical Hazards" to the product label immediately below the Environmental Hazards Statement; and under the new Physical or Chemical Hazards Statement, place a statement regarding the incompatibility of the product with other chemicals (e.g., oxidizing agents) as evidenced by the data provided in response to Guideline 830.6314 (OxidatiOlll RechlCtion; Chemical Incompatibility).

3c. The Storage and Disposal Statements are acceptable in accordance with 40 CFR § 156.1 O(i)(2)(ix) and PR Notice 83-3

.

NOTE TO CRM: The labeling issues should be addressed during label review.

### I



## 2

CONCLUSIONS:

The revised CSF is acceptable to support reregistration of the subject product. This CSF 

### Sh01l1d supersede previous CSFs for this product.

The registrant has now satisfied the product chemistry requirements for the reregistration of EPA Reg. No. 66330-334.

### (



## 1

DATE OUT: 

### 05/MARl2010

SUBJECT: PRODUCT CHEMISTRY REVIEW OF: TGAI [[: MUP [I: 

### EUP [XI 

### BARCODE NO.: D372032 REG.IFILE SYMBOL NO.: 66330-334 PRODUCT NAME: Thidiazuron 4 SC MRID NOS.: 462362-01.462448-01. and 468175-01 COMPANY NAME: Arysta LifeScience North America. LLC ACTION CODE: 676 CONTRACTOR: CSC PROJECT CODE: PRD-560PlI

FROM:

TO: 

# k-,**~(7'** Maria Rivera Piansay, Chemist!
<. 

# i' \\**~~** Product Chemistry Team \' ! \ 

### Risk Management and Implementation Branch V v Product**Re~evaluation** 

### Division (7508P)

Barbara Briscoe, CRM Risk Management and Implementation Branch V Product Re-evaluation Division (7508P)



### INTRODUCTION:

A Reregistration Eligibility Decision (RED), Case number 4092, was issued in September 2005 for the Technical Grade Active Ingredient (TGAI) Thidiazuron. According to the RED, the generic data base supporting the reregistration ofThidiazuron for eligible uses has been reviewed and found to be Sllbstantially 

### complete.

In the**8~month** 

### response to the Thidiazuron RED, Arysta LifeScience North America, LLC provided a Confidential Statement of Formula (CSF) for the basic formulation, dated 12/20/2008; 

### and a draft label (pin-punched 02125109). 

### The registrant cited product chemistry data, including MRID Nos.**462362~01, 462448~01,**  

### and**468175~0** 

### 1. The registrant is requesting reregistration of their prodlict, Thidiazuron 4 SC, 

### EPA Reg. No. 66330-334.

FINDINGS:

1. EPA Reg. No.**66330~334** 

### is an**ep.d~use** 

### cotton defoliant, containing the active ingrediel1t, Thidiazuron, with a label claim nominal concentration of 42.4%. [We note that the label claim nominal concentration does not match that in the CSF, which is 42.7%. The concentration of record with the Agency is 42.4%]. The product is a harvest aid compound, used for leaf removal prior to cotton harvest. The product is for agricultural use only. The product is prodliced by a**non~integrated** 

### system.

2. The CSF for the basic formulation is not acceptable because the label claim nominal concentration, 42.4%, does not match the concentration in the CSF, 42,7%, The label or the CSF
must be changed because these hvo must agree, in accordance with PR Notice 91-2.



### THIS REVIEW CONTAINS FIFRA CBI

## ( 

## (

2

3. The data reported in MRID Nos. 462362-01, 462448-01, and 468175-01 satisfY the product chemistry requirements as specified in 40 CFR §158.155, 158.160, 158.165, 158.167, 158.175, and 158.180 (the new 40 CFR section numbers are 158.320, 158.325, 158.335, 158.340, 158.350, and 158.355, respectively) which pertain to Product Identity and Composition, Description of Materials Used to Produce the Product, Description ofFonnulation Process, Discussion of Formation of Impurities, Certified Limits, and Enforcement Analytical Method.

The data also satisfy the product chemistry requirements as specified in 40 CFR 

### § 158.190 (the

new 

### 40 CFR number is 158.310) which pertain to the Physical and Chemical properties of the 

### product.

4. The Enforcement Analytical Method for the determination ofThidiazuron content in the product is presented in MRID No. 462448-01. The method is adequate and satisfies the requirements under Guideline 830.1800.

5a. The Active Ingredient Statement on the draft label is not acceptable as per 40 CFR §156.1 O(g) 

### and PR Notices 91-2 and 97-6. The concentrations must be harmonized as per PR Notice 91-2. See Finding 2.

5b. Data are present to trigger the need for a Physical or Chemical Hazards Statement: Add the heading "Physical or Chemical Hazards" to the product label immediately below the Environmental Hazards Statement; and under the new PhYSical or Chemical Hazards Statement, place a statement regarding the incompatibility of the product with other chemicals (e.g., oxidizing agents) as evidenced by the data provided in response to G1lideline 830.6314 (Oxidation! Reduction; Chemical Incompatibility).

5c. The Storage and Disposal Statements are acceptable in accordance with 40 CFR §156.1 0(i)(2)(ix) and PR Notice 83-3

.

NOTE TO CRM: The labeling issues should be addressed during label review.

CONCLUSIONS:

After submission of a revised CSF and!or a revised label, as noted in Findings 2 and Sa, respectively, the registrant will satisty the product chemistry requirements for the reregistration of EPA Reg. No. 66330- 334.( 

### (



## 3

Product Chemistry Data

Subgroup A: Guidelines Series 830.1550

- 830.1800 (40 CFR §158.320 -158.355) Product Identity. Composition, and Analysis

Guideline Reference No. (GRN) 40 CFR§ 

### MRIDNumber I 

### Title 830

830.1550 Product Identity and 158.320 462448-01 Composition



### 830.1600 Description of 158.325 462448-01 Materials Used to Produce the Product



### 830.1620 Description of 158.330 

### [Not required for products Production Process 

### produced 

### by a nonintezrated system!

830,1650 Description of 158.335 462448-01 Formulation Process

830.1670 Discussion of 158.340 462448-01 Formation ofImpurities



### 830.1700 Preliminary Analysis 158.345 

### [Not required/or products produced by a non

### inteI!rated system 1

830.1750 Certified Limits 158.350 462448-01 and CSF

830.1800 Enforcement Analytical 158.355 462448-01 Method



### Subgroup B: Guideline Series 830.6302

- 7950 (40 CFR §158.310) Pbysical and Chemical Properties

Guideline Reference No. Value or Qualitative MRID Number (GRN) / 

### Titl. 830 

### Deserintion

.6302 Color [Not required for end-use products.]



### .6303 Physical State LiQuid at 25°C 462362-01 

### Data Fulfilled

Y

Y

N/A



### Y

Y

N/A



### Y

Y



### Data Fulfilled

N/A



### Y

### (



## 4

Guideline Reference No. Value or Qualitative MRID Number Data (GRN) i Title 830 

### Dcscrintion Fulfilled

.6304 Odor 

### [Not required for end-lise NiA ol'Oduc/s. 7



### .6314 Oxidation! Reduction: Compatible with distilled 462362-01 

### y
Chemical Incompatibility 

### water, iron powder, and monoammonium phosphate. A reaction was observed when mixed with potassium pennanganate (Le., gas evolved; heat generated)

.

. 6315 Flammability/Flame >93°C 462362-01 Y


### Extension

.6316 Explodability Not applicable. The 462362-01 

### y product does not contain
any known explosive

comoonents

.



### . 6317 Storage Stability Time Point Active 468175-01 

### y
Conc.
Initial 42.8%
3 months 43.3%


### 6 months 43.0%
9 months 43.2%
12 months 42.9%

Results demonstrate stability for 12 months under warehouse conditions. No significant change in the active ingredient concentration (or dle product's appearance) was observed

over the l2-month interval. The product was tested in white HDPE bottles.

### ( 

### (



## 5

Guideline Reference No. Value or Qualitative MRID Number Data (GRN) 

### I Title 830 

### Description Fulfilled

.6319 Miscibility Not applicable. The 462362-01 

### Y product shall not be diluted with non-polar solvents.



### .6320 Corrosion Results demonstrate that 468175-01 

### Y Characteristics the product is not corrosive to its 

### packaging after storage for 12 months under warehouse conditions. No apparent corrosion of the packaging material due to the product

was observed. TIle product was tested in white HDPE bottles.



### ,6321 Dielectric Breakdown Not applicable. The 462362-01 

### Y Voltage product shall not be used

on or in the vicinity of electrical equipment and electrical conduits

.

. 7000 pH 5.78 at 25°C 462362-01 

### Y



### .7100 Viscosity 1236 mPa s at 25°C 462362-01 

### Y

.7300 DensityfRelative 1.1752 glmL at 25°C 462362-01 

### Y 

### Density

Explanations: Y = 

### Requirement fulfilled; N = 

### Requirement not fulfilled; 

### N/A = 

### Not applicable; G = 

### Data gap; U = 

### Upgradeable; I = 

### Incomplete or in progress; W = 

### Waived; NR = 

### Not required

Enforcement Analytical Method, Guideline 830.1800 (MRID No. 462448-01) An HPLC method is used to determine Thidiazuron content. in the product ("Determination of Thidiazuron"). The method provides procedures for preparing standards and samples, a description of the instrument system, and equations for calculations. This method is found to be adequate and would satisfY Guideline 830.1800. The HPLC system consists of the following:
Instrument: Liquid chromatograph equipped with a UV detector and

Detector: Column: Mobile Phase: integrator 283 nm, fixed wavelength
Luna C-18, 5 11m or equivalent, 15 cm x 4.6 mm Ld. 60/40: AcetonitrilelHPLC water

### Diluent: Flow Rate: Run Time: Column Temperature: 

## 6

60/40: 

### Acetonitrile/HPLC water 1.0 mLlminute 15 

### minutes 30°C



### Confidential Appendix A



### 830.1550 Product Identity and Composition

EPA Reg. No. 66330-334 is an end-use product produced 

### by a non-integrated system. The product contains the active ingredient, Thidiazuron, with a label claim nominal concentration of 42.4%. [Note that the label claim nominal concentration of the active ingredient does not match the concentration in the CSF}. The registered product, Thidiazuron Technical (EPA Reg. No. 66330-324; 98.3% active), is the

source of the active ingredient. Nominal concentrations and upper!lower certified limits are identified on 

### the CSF.

830.1600 Description of Materials Used to Produce the Product

The starting materials used in the formulation of EPA Reg. No.**66330~334** 

### are identified in MRID No.**462448~01.** 

### Technical specifications for the formulation compori.ents are provided in MRID No.**462448~** 

### 01.



### 830.1650 Description of Fonnulation Process

### THIS REVIEW CONTAINS FIFRA CBI

### (



# PRODUCT REREGISTRATION

SUPPORTING DOCUMENTATION

FOR

Case Name: 

# Th l 

# d I 

# C{zuro 

# n

This supporting documentation (in chronological order) includes:

o Old labels (identified as "Superceded by label dated xx/xx/xx')

@l 

# Unacceptable CSFs (marked "Not Acceptable" and dated)



# o Product chemistry reviews

o Acute Toxicity reviews

o Efficacy reviews (if necessary)

® 

# 90-day responses to PDCI (Form A and Form B)

® 

# Administrative forms (Application for Reregistration, Certification to Data Citation, Data Matrix)**~** 

# Correspondencerlo:[)'"....D'>,,;0D:1\\?11\Iru.-=t:i-='----,---iCcrtiITod.-=t:oR&!umFccH<;roo(End<.",:JlTh'nfRC<ju!!w)B".).'o.r..r...sC"'oe5/11/09(EnOOn:nrw.:n!RC<.lwad)oTo!aIPosbga&FflnS$rl0:0,';em0Mr.BillWashburn/RegulatoryMgr.o,),I:ysJ:.a..W-tftS.ci!l)l.c.o...............................................I;;/mti.Ap!.NO.,aorFOIkNt.'I1.15401WestonParkway.Suite150["-.._-_....-..,._-.......-....-.............-....--_.....-..........-_...-............-.Cdy,stJln,ZIPt4,-

### , 

### ! 

# , \

\\ 1 ;i ! 

# "U' '\

' , , 

### (



### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

, WASHINGTON, D,C, 20460



### CERTIFIED MAIL

Mr. Bill Washburn 

### Regulatory Manager Arysta LifeScience 

# MAY 111009 OFfiCE OF PREVENTION, PESTICIDES ANQ TOXIC SUBSTANCES



### 15401 Weston Parkway, Suite 150 Cary, NC 

### 27513



### SU8JECT: Thidiazuron Reregistration Eligibility Decision (RED), Review of Acute Toxicity Data, EPA Registration Number 66330-334

Dear Mr. Washburn:



### Your submission of acute toxicity data required in response to the thidiazuron Product Specific Data Call-In Notice has been reviewed, The Agency has determined that the acute toxicity studies are acceptable.

The acute toxicity profile for EPA Registration No. 66330-334 is currently:

Guideline 

### Study MRlDNumber 

### Toxicity Category 

### Classification

81-1 

### AtUte Oral 47685901 

### IV Acceptable/Fulfilled 81-2 Acute Dermal 

### 47685902 

### IV Acceptable/Fulfilled 81-3 Acute Inhalation 47685903 

### IV Accepta b Ie/Fulfilled 81-4 Primary Eye 

### 47685904 

### IV Acceptable/Fulfilled 81-5 Primary Dermal 

### 47685905 

### IV Acce ptab Ie/Fulfilled 81-6 

### Skin Sensitization 47685906 

### non sensitizer 

### Acceptable/Fulfilled

A detailed copy of the Data Evaluation Record is enclosed. If you have any 

### questions, you may contact Barbara Briscoe at 703-308-8177.

Sincerely,

# POv1ftt~£ 

# /lUL

Patricia L. 

### Moe, Chief Product Reregistration Branch Special Review and Reregistration Division Enclosure

## ( (



### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

CERTIFIED MAIL

Mr. Bill Washburn Regulatory Manager Arysta LifeScience 

### 15401 Weston Parkway, Suite 150 

## Cary, NC 27513 

## MAY 11 Z009

SUBJECT: Thidiazuron Reregistration Eligibility Decision (RED), Review of Acute 

### Toxicity Data, EPA Registration Number**66330~334**



### Dear Mr. Washburn:



### Your submission of acute toxicity data required in response to the thidiazuron Product Specific Data**Call~In** 

### Notice has been reviewed. The Agency has determined that the acute toxicity studies are acceptable.



### The acute toxicity profile for EPA Registration No. 66330-334 is currently:

Guideline 

### Study MRID Number 

### Toxicity Category Classification



## 81-1 Acute Oral 

## 47685901 IV A ccepta b Ie IFuI 

### fi II ed 

## 81-2 Acute Dermal 

## 47685902 IV AcceptabIejFulfiIied 

## 81-3 Acute Inhalation 

## 47685903 IV A cce ptab 

## lei FuIfi lIed 

## 81-4 Primary Eye 

## 47685904 IV A ccepta ble jFu 

### Ifil I ed 

## 81-5 Primary Dermal 

## 47685905 IV AcceptablejFulfiIied 

## 81-6 Skin Sensitization 

## 47685906 non sensitizer Accep table jFulfilie d



### A detailed copy of the Data Evaluation Record is enclosed. If 

### you have any questions, you may contact Barbara Briscoe at**703~308~8177.** 

### Sincerely,

Patricia L. 

### Moe, Chief Product Reregistration Branch Special Review and Reregistration Division Enclosure

CONCURENCES



### 7508P 

### 7J-'" 

# " \Y Briscoe 4-17-09 

## ;;'7/."

- EPA FORM 13 0-1A (1/90) Printed on Recycled Paper OFFICIAL FILE COPY

# e

Arysta LifeScience

VIA FEDEX DELIVERY (Tracking No. 7963 6824 9095)

Ms. Barbara 

### L. Briscoe, Chemical Review Manager Product Reregistration Branch Special Review and Reregistration Branch 750BP Office of Pesticide Programs U.S. Environmental Protection Agency Room 8-4900, One Potomac Yard 2777 South Crystal 

### Drive Arlington, VA 22202

Dear Ms. Briscoe:



### Subject: 

### Thidiazuron 4 SC EPA Reg. No. 66330·334

8·Month Response to Data Call·ln dated 

### 5/08/08 478869.00 February 24, 2009

Please find enclosed the following items in support of the subject product as requested 

### by the Product Specific Data Call-In for products containing thidiazuron dated May 8, 2008:



### 1. EPA Form 8570-1 (Application for Registration Amendment)

One copy of EPA Form 8570·1 

### (Application for Registration Amendment) dated January is enclosed. The application is the a-Month Response to the Data Call-In dated May 8, 2008.

2. EPA Form 8570-4 

### (Confidential Statement of Formula)

Two copies of EPA Form 8570-4 

### (Confidential Statement of 

### Formula) dated December 20, 2008 are enclosed. This form specifies the nominal concentration of the technical grade active ingredient and each of the organic impurities identified in the Group A product chemistry studies. Standard upper and lower certified limits as per 40 CFR §158.175(b)(2) have been entered for the active ingredient and each of the impurities.

3. EPA Form 8570·35 

### (Data Matrix)

One copy each of EPA Form 8570-35 

### (Data Matrix) in two formats are enclosed. The form is submitted in a non-redacted version ("Agency Intemal Use Copy") and a redacted version (,Public File Copy") as per Pesticide Registration Notice 98-5. The Public File Copy does not show the guideline reference number, the guideline study
name, and the MRID number but it does indicate the submitter and status of the data.

ArysIa LifeSclence North America. LLC 15401 Weslon Parllway, SUUe 150, Cary, NC 27513 Phone 919·678·4900 Fax 919·678·2194 www.arys1alifescience.comPage2of2



### 4. EPA Form 8570-34 **(Ceriification with**  **Respect to**  **Citation** 

### of **Data)**

One copy of EPA Form 8570-34 

### (Certification with Respect to Citation of 

### Data) is 

### enclosed. The selective method of support (or cite-all option under the selective method) has been checked in Section I.

5. Draft Label for Thidiazuron 4 

# se

Five copies of a draft label for Thidiazuron 4 SC, one redlined copy (Filename: Thidiazuron 

### 4 SC(430-08170S)(66330-334 RED 

### + PR2007-4 Redline.doc) and four clean copies (Filename: 

### Thidiazuron 

### 4 SC(430-08170S)(66330-334 RED + 

### PR2007-4 **Clean.doc)** 

### are enclosed.

6. Bibliography of Submitted Studies

One copy of the Bibliography of Submitted Studies (transmittal document) describing the submitted data in support of this registration application is enclosed.



### 7. Study Reports



### Three bound and labeled copies of each study described in the Bibliography of Submitted Studies are enclosed.

Please call on me at the e-mail address or telephone number shown below if you require any additional information or assistance in this matter. Thank you for your time and assistance in the registration of this product.

Very truly yours,

# 8~~~ Bill Washburn Regulatory Manager

Phone: (901) 432-5118 

### E-Mail: bill.washburn@arystalifescience.comArystaLifeScienceNorthAmerica,LLC15401WestonParkway,Suite150Cary,NorthCarolina27513BIBLIOGRAPHYOFSUBMITIEDSTUDIESProductName:Thidiazuron4SCEPARegistrationNumber:66330-334PurposeofSubmission:DateofSubmission:8MonthResponsetoDataCall-InFebruary24,20091016AcuteOralToxicityStudy(UDP)inRats12580-082016AcuteDermalToxicityStudyinRats12581-083016AcuteInhalationToxicityStudyinRats12582-084016AcuteEyeIrritationStudyinRabbits12583-085016AcuteDermalIrritationStudyinRabbits12584-086016ISkinSensitizationStudyinGuineaPigs12585-08870.1100870.1200870.1300870.2400870.2500870.2600Page1of1AcuteTox47896901AcuteTox47886902AcuteTox47896903AcuteTox47886904AcuteTox47886906AcuteTox47886909-UNITEDSTATESENVIRONMENTALPROTECTIONAGENCYFormApprovedOMBNo.2070·00600401MStreet,S.W.WASHINGTON,D.C.20460PaperworkReductionActNotice:Thepublicreportingburdenforthiscollectionofinformationisestimatedtoaverage0.25hoursperresponseforregistrationacliviUesand0.25hoursperresponseforreregistrationandspecialreviewactivities,includingtimeforreadingtheinstructionsandcompletingthenecessaryforms.Sendcommentsregardingtheburdenestimateoranyotheraspectofthiscollectionofinformation,includingsuggestionsforreducingtheburdento:Director,OPPEInformationManagementDivision(2137),U.S.EnvironmentalProtectionAgency,401MStreet,S.W.,Washington,DC20460.Donotsendtheformtothisaddress.DATAMATRIXDateFebruary19,2009EPAReg.No.fFileSymbol66330-334Ipage1of1Applicanl'sfRegistrant'sName&Address:ProductArystaLifeScienceNorthAmerica,LLC,15401WestonParkway,Suite100,Cary,NC275137THIDIAZURON4SCIngredient(s):ThidiazuronGuidelineReferenceNumberGuidelineStudyNameMRIDNumberSubmillerStatusNot,..ProduC'lChemistrySeries830AProductIdentityandComposition,et.al.46244801ArystaUfeScienceNorthAmericaOwnSeries8308PhysicalandChemicalCharacteristics46236201ArystaUfeScienceNorthAmericaOwn830.63171830.6320StorageStability1CorrosionCharacteristics46817501ArystaUfeScienceNorthAmericaOwnAcuteToxicology870.1100AcuteOralToxiciArystaUfeScienceNorthAmericaOwn870.1200AcuteDermalToxicityArystaUfeScienceNorthAmericaOwn870.1300AcuteInhalationToxicityArystaUfeScienceNorthAmericaOwn870.2400PrimaE eIrritationAstaUfeScienceNorthAmericaOwn870.2500PrimaDermallrritalionAstaUfeScienceNorthAmericaOwn870.2600SkinSensitizationArystaUfeScienceNorthAmericaOwn"..,.-... ..,'.,.-,,.......,',.....,·L..J......SignatureNameandTitle:BillWashburn,RegulatoryManagerDate2/19/09JEPAForm8570-35(9-97)ElectronicandPaperversionsavailable.SubmtonlyPaperversion.AgencyInternalUseCopy-oDale2009UNITEDSTATESENVIRONMENTALPROTECTIONAGENCY401MStreet,S.W,WASHINGTON,D,C.20460averagev.forreadingtheinstructionsandcompletingthenecessaryforms.burdento:Director,OPPEInformationManagementDivision(2137).DATAMATRIXEPAProductLifeScienceNorthAmerica,LLC,15401WestonParkway,Suite100,Cary,NC275137SignatureNameandTitle:66330-334BillWashburn,RegulatoryManagerEPA'FOhn6570.35\9.97)EIe<:lronicandPaperversionsavailable.SubmitonlyPaperversion.FormApprovedOMBNo.2070·0060perresponseanyotheraspectofthiscollection401MStreet,S.w.,Washington,DC20460.1of1Date2/19/09AgencyIntern.1UscCopy(



### , Fonn Approved OMS No. 2070-006



# , 

# '"' UNITED STATES ENVIRONMENTAL PROTEC1,-,N AGENCY 

# 0 401 M Street, S.W. WASHINGTON, D.C. 20460

Paperwork Reduction Act Notice: The public reporting burden for this collection of infonnation is estimated to average 1.25 hours per response for registration activities and 0.25 hours per response for reregistration and special review activities, including time for reading the instructions and completing the necessary follTls. Send comments regarding the burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden to: Director, OPPE infonnation Management Division (2137). U.S. Environmental Protection Agency, 401 M Street, S.W., Washington, DC 20460. Do not send the fonn to this address.

Certification with Respect to Citation of Data Applicant's!Registrant's Name, Address and Telephone Number EPA Registration Number! File Symbol Arysta LifeScience N. A. LLC,15401 Weston Parkway, Suite 150, Cary, NC 27513 66330-334
Active Ingredient(s) and/or representative test compound(s): Date Thidiazuron, Diuron February 19, 2009
General use pattem(s) (list all those claimed for this product using 40 CFR Part 158) Product Name Terrestrial, Non-Food Use (Cotton) THIDIAZURON 4 SC

NOTE: If your product is a 100% repackaging of another purchased EPA-registered product labeled for all the same uses on your label, you do not need to submit this fonn. You must submit the Formulator's Exemotion Statement (EPA Form 8570-27l. 

## 121 I am responding to a Data Call-In Notice, and have included with this form a list of companies sent offers of compensation (the Data Matrix form should be used for this purpose).

SECTION I: METHOD OF DATASUPPORT (Check one method only) 

## D I am using the cite-all method of support, and have included with 

## 121 I am using the selective method of support (or cite-all option this form a list of companies sent offers of compensation (the under the selective method), and have included with this fonn a Data Matrix form should be used for this purpose).**comple~i.d** list of data requirements (the Data Matrix form must be used.

SECTION II: GENERAL OFFER TO PAY
[Required if using the cite-all method or when using the cite-all option under the selective method to satisfy one or more data requirements] 

## D I hereby offer and agree to pay compensation, to other persons, with regard to the approval of this application, to the extent required by RFRA.

SECTION JJI: CERTIFICATION

I certify that this application for registration, this form for reregistration, or this Data Call-In Notice is supported by all data submitted

or cited in the application for registration, the form for reregistration, or this Data Call-In response. In addition, if cite-all option under the selective method is indicated in Section I, this application is supported by all data in the Agency's files that (1) concern the properties or effects of this product or an identical or substantially similar product, or one or more of the ingredients in this product; and (2) is a type of data that would be required to be submitted under the data requirements in effect on the date of approval of this application if the application sought the initial registration of a product of identical or similar composition and uses.

I certify that for each exclusive use study cited in support of this registration or reregistration, that I am the original submitter or that I have obtained the written permission of the original submitter to cite that study.

, < < < I certify that for each study cited in support of this registration or reregistration that is not an exclusive use stuqY...Elitller: (a) I am the original data submitter; (b) I have obtained the written permission of the original data submitter to use this study**in,~uppprt** of this application; (c) all periods of eligibility for compensation have expired for the study; (d) the study is in the public literatt.re; or (e) I have notified in writing the company that submitted the study and have offered 0) to pay compensation to the extent required by'sections 3(c)(1)(F) and/or 3(c)(2)(8) of FIFRA; and (ii) to commence negotiations to determine the amount and terms ;':lfcompensation, if any, to be paid for the use of the study. ( • : '( <,



### , , 

### " " 

# . "



### , I certify that in all instances where an offer of compensation is required, copies of all offers to pay cUIllpensat!dn**~rl(>** evidence of their delivery in accordance with sections 3(c)(1)(F) and/or 3(c)(2](B) of FIFRA are available and will be**b6~lflid;ed** to thb'clgelICY upon request. Should I fail to produce such evidence to the Agency upon request, I understand that the Agem .• ) 

### Inoy initiate action to deny, cancel or suspend the registration of my product in confonnity with FIFRA. 

# ".

, 

# . '" ( I certify that the statements I have made on this form and all attachments to it are true, accurate and cor.\plex..1 acknowledge that any knowingly false or misleading statements may be punishable by fine or imprisonment or**b'o~h':J:1'der** applicable law.

Signature

# \3~c......,C/O~ Date Typed or Printed Name and Title


### 2/19/09 Bill Washburn, Regulatory Manager



## . . EPA Form 8570 34 (9 97) ElectrOniC and Paper versions available. Submit only Paper version

.

### Pfeas~**~;_~~~QA-** 

### , reverse before comple -' fon». 

### ! 1 Approved, OMB No. 2070-0060, Approval 

## I 

# '" EPA United States 

### 0 Registration opp Identifier Number 

# 0 Environmental Protection Agency 

# o Amendment
DC 20460

Application for Pesticide

- Section I

1. 2. 3. I 

# , , I D Restricted 4. 

## 145(;

## ~~# DNone
I 5. Neme"d. "f U 6. Expedited

. In i I FIFRA Section

Arysta lifeScience North America, llC (b)(I), my product is similar or identical in composition and labeling to: 15401 Weston Parkway, Suite 150 EPA Reg. No. Cary, NC 27513 Product Name 

# n Cheok if/hi' i, a new add,."

Section 

### -II

Amendment

- Explain below. Final printed labels in response to Agency letter dated Resubmission in response to Agency letter dated

__ Notification

- EXPlain' below. ) "Me Too" Application Other

-

### EX~I~in below 

# A" : Use; I ) if necessary. (For I and I 

## 11.)

8-Month Response to Data Call-In dated May 8, 2008 for product containing thidiazuron.

Section

- III

# ~'" iI i I 

## y:!! :tee Soloble Type of I

Yes' Ye, 

# rx y., Metal
No 

### No I No Plastic I y.,' No. per Ye," No. per Glass 

### *Certification must Unit Packaging wgt. container Package wgt. container Paper 

## be

# OOf~ 

# --,:: .= I I 4. SI

.. ,,) I



## [Zl Label 

# D Container On Label 2.5 gal., 5.0 gal., and 30 gal. I OolabeUno
, pcodoct
6. o Whloh Label I, Affi"d to Pmdo" 

# o Other I II

Section -IV

1. Contact Point (Complele items direclfy below for I 

# , , , " fo pmo." !hi, Name ITllle " :: 0 e Alea

BILL WASHBURN REGULATORY MANAGER Code)



### 6. I I I certify that the statements I have made on Ihis form and all attachments thereto are true, accurate and complet3'. 'I

oode, that any knowingly false or misleading slatemenl may be punishable by fine or imprisonment or bdth**(~t"mped)** U I law. 

# .. 2:-

# ~ET~~LATORY MANAGER 

### , 

# <2,'

M 

## f •

# ""~(10.**~1~r::;JNeme** 5. Date



# . " WASHBURN 

### 2/24/09

. - .,

EPA 1 ,Rev. 8-94) I Whlte- EPA Flte Copy U-(I\iOIHu11.n';'be,Page1of4UnitedStatesEnvironmentalProtectionOMBApproval2070·0107AgencyWashingtDn,D.C.20460OMBApprova12070.0057REQUIREMENTSSTATUSANDREGISTRANT'SRESPONSEINSTRucnONS:Pleasetypeorprintinink.Pleasereadcarefullytheattachedinstructionsandsupply1heinformationrequestedonthisform.Useadditionalsheet(s)Ifnecessary.1.CompanyNameandAddress2.Case#andName3.DaleandTypeofDCIandNumberARYSTALlFESCIENCENORTHAMEAICACORPOR)4092Thidiazuron08-May-200815401WESTONPARKWAY,SUITE150PRODUCTSPECIFICCAAY,NC27513ID#PDCI-120301·26085EPAReg.No.66330-3344.Guideline5.StudyTillep6.Use7.Test8.Time9.RegistrantRequirementRProgressPatternSubstanceFrameResponse,,-,0ReportsNumberT(Months)0c0L123Erod!,!etCheml!;l:t!:llChemical)830.1550,ProductlderrlNyandcomposition(1)A,B,C,D,E,F,G,H,I,TGAI/MP/EPLPJ.K.L,M,N,0...830:1800/Descrip1ionofmaterials'usedtoproduce1heproduct·(2)'A,B,C,'D;'E','F;'G,H,I,TGAl/MP/EP::.,-,B("_J';·K,L,M;N;_0__830.1620Descriptionofproductionprocess(3)A,B,C,D,E,F,G,H,I,TGAIBIJ,K,L,M,N,0830.1650.Descriplion'o(formi:ilalionproc_ess(4)A,B,C,D,'E,'F,_G;i{i,MP/EP_.-r.""..--J,K,L"ryJ,__. _.-..------"''''830.1670,DiscussionoflonnationofImpurities(5)A,B,C,D,E,F,G,H,I,TGAI/MP/EPB[0J,K,L,M,N,0-830,1700----Prelll'ninary,inalysis._,(6.7,8)•.A;'B.C;D,-'E,F,G,H,I,TGAI..N,Q,..._..--830.1750VCertifiedlimits(9,10)A.B,C,D,E,F,G,H.I.TGAI/MP/EPBI.eJ.K.L.M.N,0Enforcement'arialitlCiilmeihod(11)•••.A,B;C,D;-E,-F;'G;'H,I,TGAI/MP/EP"_,"......•I"--.--.---.I.J,K,:_l.,}J),:_Ni.O__830.6302Color(19)A,B,C,D.E.F.G,H.I,TGAIIMP/EPI.••IJ.K,L,M,N,O830.63-03';v"""-PhySicalstate,--..,,,."'"..(22)_.""E,_F,"G:'f-(f,'TGAIIMPJEP":'..."..10.....,...••"."'.-""",--..,,0,....""__•-----,..-."...l,:N,0__..,::.,,-,":-,.,,-..--',...--.,""....,,"""---.--830.6304Odor(23)A,B,C,D,E,F,G,H,I.TGAI/MP/EPB/,J,K,L,M.N,010.CertifjcalionIcertifythat1hestatementsmadeonthisallattachmerrlsaretrue,accurate,andcomplete.Iacknowledgethaiany11.DateB/sioBknowinglyfalseormisleadingstatementmaybepunishablebye,orbothunderappflcablela:vSignatureandTilleofCompany'sAuthorizedRepresentaliveJtJDC\-':)'Pe'/:,vtciO<l1W,o.flC&er'12.NameofCompanyA."Isic.SC'<"aceNod-\"('tiN:>'iCc,LLC13.PhoneNumber'1'0\'<-\,;Z51IE>Page2of4UnitedStatesEnvironmentalProtectionOMBApproval2070-0107AgencyWashington,D,C.20460OMBApproval2070-0057REQUIREMENTSSTATUSANDREGISTRANT'SRESPONSEINSTRUCTIONS:Pleasetypeorprintinink.Pleasereadcarefullytheattachedinstruclionsandsupplytheinformationrequestedonthisform.Useadditionalsheet{s)IInecessary.1.CompanyNameandAddress2.Case#andName3.DateandTypeofDCIandNumberARYSTALlFESCIENCENORTHAMERICACORPOR}4092ThidiazuronOB-May-200815401WESTONPARKWAY,SUITE150PRODUCTSPECIFICCARY,NC27513EPAReg.No.66330-33410#PDCI-120301-260854.Guideline5.StudyTillep6.Use7.Test8.Time9.Registrant.RProgressRequirement0ReportsPattemSubstanceFrameResponseNumberT(Months)0C0L(23830.6313StabffitYtosunlight,normalanifefevated(f2,13)A,B,C,0,E,-F','G,H'-I;TGAI"If'temperatures,metals,i(ms..... .J,K,L,M,N,D830.6314vOxidizingorreducingaction(14)A,B,C,D,E,F,G,H,I,MP/EPCoJ,K,L,M,N,0830.6315-v.Flammability(IS)'.A,B,C,D,E,-F,G,HI,MP/EP-W..J,K,L,M,N,0.830.6316Explodabllity(16)A,B,C,0,E,F,G,H,I,MP/EPBJ,K,L,M,N,0I830.6317Storagestability01product(1'7)'....-A;s;C;b;E.F,_G,H,I,MP/EPB'.t".J-.KLL,_M,_N,_O"....'.830.63t9MiscibUity(18)A,B,C,0,E,F,G,H,I,MP/EPJ,K,LM,N,°Cor-rOSion-characterIstics:(2'Oj"'•A,B,-C,'D,E,F,G,H,I,MP1EP'"&,-830.6320........B--"""-K,L.M,_N,0.-....'830.6321Dielectricbreakdownvoltage(21)A,B,C,0,E,F,G,H,I,MP/EPJ,K,L,M,N,DpHofwatersolutloriflor'su.iibensionsA,B,C,D,E.;F;'o;-H;'1;-'w···'v'_(24,25)TGAI/MP/EPJ,K,(,M,N,O............,"""'"""""-'"'---""""-,---".....,,""--,,--......'830.7050UVNisibleabsorptionA,B,C,D,E,F,G,H,I,TGAI/PAIBJ,K,L,M,N,D830)100........\itSC:,osity(26).,.'.I""A,:S,'C;-D,E,F,_G,-H,I;MPiEP.BiJJ..........."..-,_._."..........--..'-_.,.-----"-..,,,"',._"",-..."'''''!<,l,.,M,.N,0__::",,__-_:_"._",,---......'"""-'".830.7200Mellingpointlmeltingrange(27.28)A,B,C,D,E,F,G,H,I,TGAIJ,K,L,M,N,0Initialtoindicatecertificationastoinformationonthispage\b:vDate6(8(OB(fulltextofcertiilcationisonpageone).Page30f4UnitedStatesEnvironmentalProtectionOMBApproval2070-0107AgencyWashington,D.C.20460OMBApprovnl2070-0057REQUIREMENTSSTATUSANDREGISTRANT'SRESPONSEINSTRUCTIONS:Pleasetypeorprintinink.Pleasereadcaretullytheattachedinstructionsandsupplytheinformationrequestedonthistorm.Useadditionalsheet(s)ifnecessary.1.CompanyNameandAddress2.Case#andName3.DateandTypeotDCIandNumberARySTAUFESCIENCENORTHAMERICACORPORI4092Thidiazuron08-May-200815401WESTONPARKWAY,SUITE150PRODUCTSPECIFICCARY,NC27513ID#PDCI-120301-26085EPAReg.No.66330-3344.Guideline5.StudyTilleP6.Use7.Test8.Time9.RegistrantRequirement0PatternSubstanceFrameResponse.-NumberTepos(Months)og/-..--r--IL 1 2 3830.722080iliri"g'PoinVboliingrange(2"9',30)'A"s,C,D,-E,F,13,H,I,TGAII..J,K,L,M,N,0.'.....830.7300VDensitylrelalivedensity(31,32)A,B,C,D,E,F,G,H,I,TGAI/MP/EPCoJ,K,L,M,N,0830.7370Dissociationconstantinwater(42,43)" -_:__A,B,C"D,E,F,G;'H,'I.TGAIor'PAl__"._....,_.,,.__.:."J;K,L,M,N,0----'830.7550Partitioncoefficient(n-octanoVwater),shakeflask(44)A,B,C,D,E,F,G,H,I,TGAI/PAI8methodJ,K,L,M,N,0830.7570.pi.:rtitkincoe'fflC:rent(n-octanoVwater),eStirmrtkinby"(4-5)"I,""I""A,8;C,D,E,F,13,H,I,TGAI/PAI8__"..J,K,L"M,N,0 -830.7840Watersolubility:Columnelutionmethod,shakeflask(46)A,B,C,D,E,F,13,H,I,TGAIorPAl8methodJ,K,L,M,N,0830:7860Watersolubility,generaiorcolifmnmethod(47)".--_,A.B;C,D,-E;F;"13",lU;T<3.6."(-':"0'_...__.___.'..'_"'k..M"N,"P::__,__,_..'"''830.7950Vaporpressure(48,49)A,S,C,D,E,F,13,H,I,TGAIorPAl8J,K,L,M,N,0Toxicolo1\;.'0:11:11.-",Irmensconveriticiiiai"cit'mflie":_,,I:::::1"'-I::::;:;::1,--··. ,..........'.'.'.......I.,...............".870.1100AcuteOralToxicity(36)A,B,C,D,E,F,G,H,I,TGAI,EP,diluteEP?'I.J,K,L,M,N,0870.1200':-Acutedermaltoxicity--,-""(33:34),_- _/':.......---13,H,.I,T<3:Ai;"EP;cfjiute__E'P'?"0'-- -I:.:;__1"::,;,<:-_...--..',', ,..--870.t300Acuteinhalationtoxicity(35)A,B,C,D,E,F,13,H,I,TGAI&EPj'!J,K,L,M,N,0InitialtoindicatecertilicationastoInrormationonthispage,DateO'{r/[0rl(fulltextofcertiticalionisonpageone).VIJ-J01)0Page4of4UnitedStates EnvironmentalProtectionOMSAppll}va12070-0107AgencyWashington,D.C.20460OMSApprnva12070-00S7REQUIREMENTSSTATUSANDREGISTRANT'SRESPONSEINSTRUCTIONS:Pleasetypeorprintinink.Pleasereadcarefullytheattachedinstruclionsandsupplytheinformationrequestedonthisform.Useadditionalsheet(s)ifnecessary.1.CompanyNameandAddress2.Case#andName3.DateandTypeofDCIandNumberARYSTALlFESCIENCENORTHAMERICACORPORI4092ThidiazuronOB-May-200B15401WESTONPARKWAY,SUITE150PRODUCTSPECIFICCARY,NC2751310#PDCI-120301-260B5EPAReg.No.66330-3344.Guideline5.StudyTItlep6.Use7.Test8.Time9.RegistranJ_,RProgressRequirement0ReportsPatternSubstanceFrameResponseNumberT(Months)0C0L1 23870.2400Acuteeyeirritation"""(37)IA,B,C,D,E,F,G,H;I,TGAI&EPI .N,O'870.2500Acutedermalirritation(38,39)A,B,C,0,E,F,G,H,I,TGAI&EP8'/'.IJ,K,L,M,N,0870.2600Skinsensitization..(40,41)Aj-B,C,0,E,F,'G,'H;I,TGAI&EP8),.,,'"J,K,L,M.N.0....InilialtoindicatecertificationastoinformationonthispageQouDate(fulltextofcertificationisonpageone).