SECURITIES
EXCHANGE AGREEMENT


 


This
Securities Exchange Agreement (this “Agreement”) is dated as of May ___, 2017, between Advanced Medical Isotope
Corporation, a Delaware corporation (the “Company”), and ________________ (“Holder”).


 


WHEREAS,
the Holder currently holds various convertible promissory notes of the Company (the “Notes”), issued on November
2, 2016 to various investors and assigned to the Holder pursuant to an assignment agreement, in the aggregate amount (including
principal and interest) of $__________ (the “Aggregate Outstanding Amount”);


 


WHEREAS,
the Notes are currently due and payable by the Company to the Holder; and


 


WHEREAS,
subject to the terms and conditions set forth in this Agreement and pursuant to Section 3(a)(9) of the Securities Act of 1933,
as amended (the “Securities Act”), the Company desires, in lieu of payment of the Notes, to issue a Debenture
(as defined below) and shares of Preferred Stock (as defined below) to the Holder in exchange for the Notes and the Holder desires,
in lieu of payment of the Notes, to receive the Debenture and shares of Preferred Stock in exchange for its Notes, as more fully
described in this Agreement (the “Exchange”);


 


NOW,
THEREFORE, IN CONSIDERATION of the mutual covenants contained in this Agreement, and for other good and valuable consideration
the receipt and adequacy of which are hereby acknowledged, the Company and the Holder agree as follows:


 


ARTICLE
I.


DEFINITIONS


 


1.1       Definitions.
In addition to the terms defined elsewhere in this Agreement (a) capitalized terms that are not otherwise defined herein have
the meanings given to such terms in the Purchase Agreement (as defined herein), and (b) the following terms have the meanings
set forth in this Section 1.1:


 


“Affiliate”
means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or is under common
control with a Person, as such terms are used in and construed under Rule 405 under the Securities Act.


 


“Board
of Directors”means the board of directors of the Company.


 


“Business
Day” means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States or
any day on which banking institutions in the State of New York are authorized or required by law or other governmental action
to close.


 


“Closing”
means the closing of the Exchange pursuant to Section 2.1.


 


“Closing
Date” means the Trading Day on which this Agreement has been executed and delivered by the applicable parties thereto,
and all conditions precedent to the Holder’s and Company’s obligations to proceed with the Closing and Exchange, in
each case, have been satisfied or waived.


 




    	 	 	 



    	 



    


 


“Commission”
means the United States Securities and Exchange Commission.


 


“Common
Stock” means the common stock of the Company, par value $0.001 per share, and any other class of securities into which
such securities may hereafter be reclassified or changed.


 


“Company
Counsel” means Disclosure Law Group, a Professional Corporation, with offices located at 600 West Broadway, Suite 700,
San Diego, California 92101.


 


“Debenture”
means the 7.5% Original Issue Discount Senior Secured Convertible Debenture due, subject to the terms therein, twelve (12) months
from its date of issuance, issued by the Company to the Holder hereunder pursuant to the Exchange in the principal amount of $_____________
(or 125% of the Aggregate Outstanding Amount).


 


“Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.


 


“Liens”
means a lien, charge, security interest, encumbrance, right of first refusal, preemptive right or other restriction.


 


“Material
Adverse Effect” shall have the meaning assigned to such term in Section 3.1(b).


 


“Person”
means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.


 


“Preferred
Stock” shall mean the Series A Convertible Preferred Stock issuable pursuant to that certain Certificate of Designation.


 


“Proceeding”
means an action, claim, suit, investigation or proceeding (including, without limitation, an informal investigation or partial
proceeding, such as a deposition), whether commenced or threatened.


 


“Public
Information Failure” shall have the meaning ascribed to such term in Section 4.3(b).


 


“Public
Information Failure Payments” shall have the meaning ascribed to such term in Section 4.3(b).


 


“Purchase
Agreement” means the Securities Purchase Agreement, dated as of May __, 2017 among the Company and the Holders, as amended,
modified or supplemented from time to time in accordance with its terms, pursuant to which the Holder purchased a debenture and
shares of Series A convertible preferred stock.


 




    	 	2	 



    	 



    

 


“Required
Minimum” means, the product of 400% of (i) the maximum aggregate number of shares of Common Stock then issued or potentially
issuable in the future pursuant to the Transaction Documents, including any Underlying Shares issuable upon conversion in full
of all Debentures and all shares of Preferred Stock (including Underlying Shares issuable as payment of interest on the Debentures),
ignoring any conversion or exercise limits set forth therein.


 


“Rule
144” means Rule 144 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended from time
to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule.


 


“Securities”
means the Debentures, the shares of Preferred Stock and the Underlying Shares.


 


“Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.


 


“Trading
Day” means a day on which the principal Trading Market is open for trading.


 


“Trading
Market” means any of the following markets or exchanges on which the Common Stock is listed or quoted for trading on
the date in question: the NYSE MKT, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the
New York Stock Exchange, OTCQB or OTCQX (or any successors to any of the foregoing).


 


“Transaction
Documents” means this Agreement, the Debentures, the Security Agreement, all exhibits and schedules thereto and hereto
and any other documents or agreements executed in connection with the transactions contemplated hereunder.


 


“Underlying
Shares” means the shares of Common Stock issued and issuable upon conversion or redemption of the Debenture and Preferred
Stock, including without limitation, shares of Common Stock issued and issuable in lieu of the cash payment of interest on the
Debentures in accordance with the terms of the Debentures, in each case without respect to any limitation or restriction on the
conversion of the Debentures or the shares of Preferred Stock.


 


ARTICLE
II.


EXCHANGE


 


2.1       Closing.
On the Closing Date, upon the terms and subject to the conditions set forth herein, concurrent with the execution and delivery
of this Agreement by the parties hereto, the Company shall issue to the Holder, in exchange for the Note, the Debenture and _________
shares of Preferred Stock. Upon satisfaction of the covenants and conditions set forth in Sections 2.2 and 2.3, the Closing shall
occur at the offices of Company Counsel or such other location as the parties shall mutually agree.


 




    	 	3	 



    	 



    

 


		2.2	Deliveries.



 


(a)       On
or prior to the Closing Date, the Company shall deliver or cause to be delivered to the Holder the following:


 


		(i)	this
                                         Agreement duly executed by the Company;



 


(ii)       the
Debenture, registered in the name of the Holder;


 


(iii)       ________
shares of Preferred Stock convertible into _________ shares of Common Stock; and


 


(iv)       the
Security Agreement, duly executed by the Company, along with all of the Security Documents.


 


(b)       On
or prior to the Closing Date, the Holder shall deliver or cause to be delivered to the Company the following:


 


		(i)	this
                                         Agreement duly executed by the Holder; and



 


		(ii)	the
                                         Note.



 


		2.3	Closing
                                         Conditions.



 


(a)       The
obligations of the Company hereunder in connection with the Closing are subject to the following conditions being met:


 


(i)       the
accuracy in all material respects on the Closing Date of the representations and warranties of the Holder contained herein (unless
as of a specific date therein in which case they shall be accurate as of such date);


 


(ii)       all
obligations, covenants and agreements of the Holder required to be performed at or prior to the Closing Date shall have been performed;
and


 


(iii)       the
delivery by the Holder of the items set forth in Section 2.2(b) of this Agreement.


 


(b)       The
respective obligations of the Holder hereunder in connection with the Closing are subject to the following conditions being met:


 


(i)       the
accuracy in all material respects when made and on the Closing Date of the representations and warranties of the Company contained
herein (unless as of a specific date therein);


 


(ii)       all
obligations, covenants and agreements of the Company required to be performed at or prior to the Closing Date shall have been
performed;


 




    	 	4	 



    	 



    

 


(iii)       the
delivery by the Company of the items set forth in Section 2.2(a) of this Agreement;


 


(iv)       the
Company shall have delivered a Certificate, executed on behalf of the Company by its Secretary, dated as of the Closing Date,
certifying the resolutions adopted by the Board of Directors of the Company approving the transactions contemplated by this Agreement
and the other Transaction Documents and the Exchange, certifying the current versions of the Certificate of Incorporation and
Bylaws of the Company and certifying as to the signatures and authority of persons signing the Transaction Documents and related
documents on behalf of the Company; and


 


(v)       the
Company shall have delivered a Certificate, executed on behalf of the Company by its Chief Executive Officer or its Chief Financial
Officer, dated as of the Closing Date, certifying to the fulfillment of the conditions specified in this Section 2.3(b).


 


ARTICLE
III.


REPRESENTATIONS
AND WARRANTIES


 


3.1       Representations
and Warranties of the Company. Each of the representations and warranties (together with any related disclosure schedules
thereto) made by the Company to the Holder in the Purchase Agreement are hereby incorporated herein by reference (as though fully
restated herein) and are, as of the date of this Agreement, hereby made to, and in favor of, the Holder. In addition to the foregoing,
the Company represents and warrants to the Holder that:


 


(a)       Authorization;
Enforcement. The Company has the requisite corporate power and authority to enter into and to consummate the transactions
contemplated by this Agreement and otherwise to carry out its obligations hereunder and thereunder. The execution and delivery
of this Agreement by the Company and the consummation by it of the transactions contemplated hereby and thereby have been duly
authorized by all necessary action on the part of the Company and no further action is required by the Company, the Board of Directors
or the Company’s stockholders in connection therewith. This Agreement has been duly executed by the Company and, when delivered
in accordance with the terms hereof and thereof, will constitute the valid and binding obligation of the Company enforceable against
the Company in accordance with its terms, except: (i) as limited by general equitable principles and applicable bankruptcy, insolvency,
reorganization, moratorium and other laws of general application affecting enforcement of creditors’ rights generally, (ii)
as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies and (iii)
insofar as indemnification and contribution provisions may be limited by applicable law.


 




    	 	5	 



    	 



    

 


(b)       Issuance
of the Securities. The Securities are duly authorized and, when issued and paid for in accordance with the applicable Transaction
Documents, will be duly and validly issued, fully paid and nonassessable, free and clear of all Liens imposed by the Company other
than restrictions on transfer provided for in this Agreement. The Company has reserved from its duly authorized capital stock
a number of shares of Common Stock for issuance equal to at least the Required Minimum.


 


(c)       Holding
Period for Securities. Pursuant to Rule 144, the holding period of the Debenture and shares of Preferred Stock shall tack
back to November 2, 2016, the original issue date of the Notes. The Company agrees not to take a position contrary to this Section
3.1(c). Accordingly, upon conversion of the Debenture or the Preferred Stock, the Company agrees to take all actions, including,
without limitation, the issuance by its legal counsel of any necessary legal opinions, necessary to issue the Underlying Shares
without restriction and not containing any restrictive legend without the need for any action by the Holder.


 


(d)       General
Solicitation. The Company has not undertaken any advertisement, article, notice or other communication regarding the exchange
of Notes into the Debenture and shares of Preferred Stock or otherwise published in any newspaper, magazine or similar media or
broadcast over television or radio or presented at any seminar or any other general solicitation or general advertisement.


 


3.2       Representations
and Warranties of the Holder. The Holder hereby represents and warrants as of the date hereof and as of the Closing Date to
the Company as follows:


 


(a)       Organization;
Authority. The execution and delivery of this Agreement and performance by the Holder of the transactions contemplated this
Agreement have been duly authorized by all necessary corporate, partnership, limited liability company or similar action, as applicable,
on the part of the Holder. This Agreement has been duly executed by the Holder, and when delivered by the Holder in accordance
with the terms hereof, will constitute the valid and legally binding obligation of the Holder, enforceable against it in accordance
with its terms, except: (i) as limited by general equitable principles and applicable bankruptcy, insolvency, reorganization,
moratorium and other laws of general application affecting enforcement of creditors’ rights generally, (ii) as limited by
laws relating to the availability of specific performance, injunctive relief or other equitable remedies and (iii) insofar as
indemnification and contribution provisions may be limited by applicable law.


 


(e)       General
Solicitation. Such Holder is not exchanging the Note as a result of any advertisement, article, notice or other communication
regarding the Debenture and shares of Preferred Stock published in any newspaper, magazine or similar media or broadcast over
television or radio or presented at any seminar or any other general solicitation or general advertisement.


 




    	 	6	 



    	 



    

 


ARTICLE
IV.


OTHER
AGREEMENTS OF THE PARTIES


 


4.1       Transfer
Restrictions.


 


(a)       Provided
that the Company is then in compliance with the current public information requirements under Rule 144, the certificates evidencing
the Underlying Shares shall not contain any legend. Accordingly, upon execution of this Agreement, the Company shall issue irrevocable
instructions to the Transfer Agent and any subsequent transfer agent in a form acceptable to the Holder along with an opinion
of counsel on behalf of the Company and acceptable to the Transfer Agent (the “Irrevocable Transfer Agent Instructions”)
to issue certificates or credit shares to the applicable balance accounts at DTC, registered in the name of the Holder or its
respective nominee(s), for the Underlying Shares in such amounts as specified from time to time by the Holder to the Company upon
conversion of the Debentures or Preferred Stock (as the case may be). The Company represents, warrants and covenants that no instruction
other than the Irrevocable Transfer Agent Instructions referred to in this Section 4.1(a), and stop transfer instructions to give
effect to Section 4.1 hereof, will be given by the Company to its Transfer Agent with respect to the Underlying Shares, and that
the Underlying Shares shall otherwise be freely transferable on the books and records of the Company, as applicable, to the extent
provided in this Agreement and the other Transaction Documents. If, after the Effective Date, the Holder effects a sale, assignment
or transfer of the Securities, the Company shall permit the transfer and shall promptly instruct its Transfer Agent to issue one
or more certificates or credit shares to the applicable balance accounts at DTC in such name and in such denominations as specified
by the Holder to effect such sale, transfer or assignment. In the event that such sale, assignment or transfer involves the Underlying
Shares, the Transfer Agent shall issue such shares to such Holder, assignee or transferee (as the case may be) without any restrictive
legend in accordance with this Section 4.1(a). The Company acknowledges that a breach by it of its obligations hereunder will
cause irreparable harm to the Holder. Accordingly, the Company acknowledges that the remedy at law for a breach of its obligations
under this Section 4.1 will be inadequate and agrees, in the event of a breach or threatened breach by the Company of the provisions
of this Section 4.1, that the Holder shall be entitled, in addition to all other available remedies, to an order and/or injunction
restraining any breach and requiring immediate issuance and transfer, without the necessity of showing economic loss and without
any bond or other security being required. The Company shall cause its counsel to issue the legal opinion referred to in the Irrevocable
Transfer Agent Instructions to the Transfer Agent immediately following execution of this Agreement. Any fees (with respect to
the Transfer Agent, counsel to the Company or otherwise) associated with the issuance of such opinion or the removal of any legends
on any of the Securities shall be borne by the Company. In the event that, after the date hereof and through November 2, 2017
(but only until November 2, 2017, the “Public Information Period”), the Company is not in compliance with the
public information requirements of Rule 144 (“Public Information Failure”), the Holder shall return any Underlying
Shares then held by the Holder and a new certificate representing such Underlying Shares shall be issued to the Holder with the
following legend:


 




    	 	7	 



    	 



    

 


“THIS
SECURITY HAS NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE
UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY,
MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE
EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH
APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF
WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY. THIS SECURITY MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT
WITH A REGISTERED BROKER-DEALER OR OTHER LOAN WITH A FINANCIAL INSTITUTION THAT IS AN “ACCREDITED INVESTOR” AS DEFINED
IN RULE 501(a) UNDER THE SECURITIES ACT OR OTHER LOAN SECURED BY SUCH SECURITIES.”


 


(b)       Upon
written notice from the Company during the Public Information Period that the public information requirements of Rule 144 are
no longer met, the Holder will cease sales of the Underlying Shares and promptly return the Underlying Shares to the Company to
be re-issued pursuant to the legending requirements above. Upon the Company becoming again meeting the public information requirements
under Rule 144, the Company agrees that it will, no later than two Trading Days following the delivery by the Holder to the Company
or the Company’s transfer agent of a certificate representing Underlying Shares re-issued pursuant to clause (a) above and
issued with a restrictive legend transmit or cause to be transmitted to the Holder the Underlying Shares, free from all restrictive
and other legends, by crediting the DTC account of the Holder’s prime broker as directed by the Holder. Notwithstanding
anything herein to the contrary, the Holder shall have the right to provide a legal opinion of counsel reasonably acceptable to
the Company of its own to the effect that the legends may be removed and/or the Underlying Shares may be resold pursuant to an
exemption from registration under the Securities Act.


 


(c)       During
any periods that the Underlying Shares are legended and may not be resold by the Holder because of a Public Information Failure
or the Company has not timely complied with the requirements to remove legends hereunder, in addition to any other available remedies
to the Holder, the Company shall pay to the Holder in cash as liquidated damages and not as a penalty, for each $1,000 of Underlying
Shares (based on the VWAP of the Common Stock on the date such Underlying Shares are submitted to the Transfer Agent) delivered
for removal of the restrictive legend, $10 per Trading Day (increasing to $20 per Trading Day five (5) Trading Days after such
damages have begun to accrue) for each Trading Day until such certificate is delivered without a legend, which shall be payable
on the first day of each month until the Public Information Failure no longer exists.


 


4.2       Holder
Trading Limitation. Unless otherwise agreed by the Company and the Holder, the Holder agrees that for the period ending on
November 2, 2017 it shall not sell shares of Common Stock on any Trading Day equal to, or in excess of, the greater of (i) $2,063
(based on the VWAP of the Common Stock on the prior Trading Day) and (ii) 10.3125% of the trading volume of the Common Stock on
that same Trading Day. Notwithstanding the foregoing, this limitation shall not be in effect at any time during which there is
an “Event of Default” (as such term is defined in the Debenture) pursuant to the terms of the Debenture.


 




    	 	8	 



    	 



    

 


4.3       Indemnification
of Holder. Subject to the provisions of this Section 4.3, the Company will indemnify and hold the Holder and its directors,
officers, shareholders, members, partners, employees and agents (and any other Persons with a functionally equivalent role of
a Person holding such titles notwithstanding a lack of such title or any other title), each Person who controls the Holder (within
the meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act), and the directors, officers, shareholders,
agents, members, partners or employees (and any other Persons with a functionally equivalent role of a Person holding such titles
notwithstanding a lack of such title or any other title) of such controlling persons (each, a “Holder Party”)
harmless from any and all losses, liabilities, obligations, claims, contingencies, damages, costs and expenses, including all
judgments, amounts paid in settlements, court costs and reasonable attorneys’ fees and costs of investigation that any the
Holder Party may suffer or incur as a result of or relating to (a) any breach of any of the representations, warranties, covenants
or agreements made by the Company in this Agreement or in the other Transaction Documents or (b) any action instituted against
any Holder Party in any capacity, or any of them or their respective Affiliates, by any stockholder of the Company who is not
an Affiliate of the Holder Party, with respect to any of the transactions contemplated by the Transaction Documents (unless such
action is based upon a breach of the Holder Party’s representations, warranties or covenants under the Transaction Documents
or any agreements or understandings the Holder Party may have with any such stockholder or any violations by such Holder Party
of state or federal securities laws or any conduct by the Holder Party which constitutes fraud, gross negligence, willful misconduct
or malfeasance). If any action shall be brought against any Holder Party in respect of which indemnity may be sought pursuant
to this Agreement, the Holder Party shall promptly notify the Company in writing, and the Company shall have the right to assume
the defense thereof with counsel of its own choosing reasonably acceptable to the Holder Party. Any Holder Party shall have the
right to employ separate counsel in any such action and participate in the defense thereof, but the fees and expenses of such
counsel shall be at the expense of the Holder Party except to the extent that (i) the employment thereof has been specifically
authorized by the Company in writing, (ii) the Company has failed after a reasonable period of time to assume such defense and
to employ counsel or (iii) in such action there is, in the reasonable opinion of counsel, a material conflict on any material
issue between the position of the Company and the position of the Holder Party, in which case the Company shall be responsible
for the reasonable fees and expenses of no more than one such separate counsel. The Company will not be liable to any Holder Party
under this Agreement (y) for any settlement by the Holder Party effected without the Company’s prior written consent, which
shall not be unreasonably withheld or delayed; or (z) to the extent, but only to the extent that a loss, claim, damage or liability
is attributable to any Holder Party’s breach of any of the representations, warranties, covenants or agreements made by
the Holder Party in this Agreement or in the other Transaction Documents. The indemnification required by this Section 4.3 shall
be made by periodic payments of the amount thereof during the course of the investigation or defense, as and when bills are received
or are incurred. The indemnity agreements contained herein shall be in addition to any cause of action or similar right of any
Holder Party against the Company or others and any liabilities the Company may be subject to pursuant to law.


 




    	 	9	 



    	 



    

 


4.4       Conversion
Procedures. The form of Notice of Conversion included in the Debenture and Preferred Stock set forth the totality of the procedures
required of the Holder in order to convert the Debentures or Preferred Stock. Without limiting the preceding sentences, no ink-original
Notice of Exercise or Notice of Conversion shall be required, nor shall any medallion guarantee (or other type of guarantee or
notarization) of any Notice of Conversion form be required in order to convert the Debenture or Preferred Stock. No additional
legal opinion, other information or instructions shall be required of the Holder to convert its Debenture or Preferred Stock.
The Company shall honor conversions of the Debenture and Preferred Stock and shall deliver Underlying Shares in accordance with
the terms, conditions and time periods set forth in the Transaction Documents.


 


4.5       Securities
Laws Disclosure; Publicity. The Company shall (a) by 9:30 a.m. (New York City time) on the Trading Day immediately following
the date hereof, issue a press release disclosing the material terms of the transactions contemplated hereby, and (b) file a Current
Report on Form 8-K, including the Transaction Documents as exhibits thereto, with the Commission within the time required by the
Exchange Act. From and after the filing of such press release, the Company represents to the Holder that it shall have publicly
disclosed all material, non-public information delivered to the Holder by the Company, or any of their respective officers, directors,
employees or agents in connection with the transactions contemplated by the Transaction Documents. In addition, effective upon
the filing of such press release, the Company acknowledges and agrees that any and all confidentiality or similar obligations
under any agreement, whether written or oral, between the Company or any of its respective officers, directors, agents, employees
or Affiliates on the one hand, and the Holder or any of its Affiliates on the other hand, shall terminate. The Company and Holder
shall consult with each other in issuing any other press releases with respect to the transactions contemplated hereby, and neither
the Company nor the Holder shall issue any such press release nor otherwise make any such public statement without the prior consent
of the Company, with respect to any press release of the Holder, or without the prior consent of the Holder, with respect to any
press release of the Company, which consent shall not unreasonably be withheld or delayed, except if such disclosure is required
by law, in which case the disclosing party shall promptly provide the other party with prior notice of such public statement or
communication. Notwithstanding the foregoing, the Company shall not publicly disclose the name of the Holder, or include the name
of the Holder in any filing with the Commission or any regulatory agency or Trading Market, without the prior written consent
of the Holder, except: (a) as required by federal securities law in connection with the filing of final Transaction Documents
with the Commission and (b) to the extent such disclosure is required by law or Trading Market regulations, in which case the
Company shall provide the Holders with prior notice of such disclosure permitted under this clause (b).


 


4.6       Shareholder
Rights Plan. No claim will be made or enforced by the Company or, with the consent of the Company, any other Person, that
the Holder is an “Acquiring Person” under any control share acquisition, business combination, poison pill
(including any distribution under a rights agreement) or similar anti-takeover plan or arrangement in effect or hereafter adopted
by the Company, or that the Holder could be deemed to trigger the provisions of any such plan or arrangement, by virtue of receiving
Securities under the Transaction Documents or under any other agreement between the Company and the Holder.


 




    	 	10	 



    	 



    

 


4.7       Non-Public
Information. Except with respect to the material terms and conditions of the transactions contemplated by the Transaction
Documents, which shall be disclosed pursuant to Section 4.5, the Company covenants and agrees that neither it, nor any other Person
acting on its behalf will provide the Holder or its agents or counsel with any information that constitutes, or the Company reasonably
believes constitutes, material non-public information, unless prior thereto the Holder shall have consented to the receipt of
such information and agreed with the Company to keep such information confidential. The Company understands and confirms that
the Holder shall be relying on the foregoing covenant in effecting transactions in securities of the Company. To the extent that
the Company delivers any material, non-public information to the Holder without the Holder’s consent, the Company hereby
covenants and agrees that the Holder shall not have any duty of confidentiality to the Company, any of its future subsidiaries,
or any of their respective officers, directors, agents, employees or Affiliates, or a duty to the Company, and of its future subsidiaries
or any of their respective officers, directors, agents, employees or Affiliates not to trade on the basis of, such material, non-public
information, provided that the Holder shall remain subject to applicable law. To the extent that any notice provided pursuant
to any Transaction Document constitutes, or contains, material, non-public information regarding the Company or any of its future
subsidiaries, the Company shall simultaneously file such notice with the Commission pursuant to a Current Report on Form 8-K.
The Company understands and confirms that the Holder shall be relying on the foregoing covenant in effecting transactions in securities
of the Company.


 


4.8       Reservation
and Listing of Securities.


 


(a)       The
Company shall maintain a reserve of the Required Minimum from its duly authorized shares of Common Stock for issuance pursuant
to the Transaction Documents in such amount as may then be required to fulfill its obligations in full under the Transaction Documents.


 


(b)       If,
on any date, the number of authorized but unissued (and otherwise unreserved) shares of Common Stock is less than the Required
Minimum on such date, then the Board of Directors shall use commercially reasonable efforts to amend the Company’s certificate
or articles of incorporation to increase the number of authorized but unissued shares of Common Stock to at least the Required
Minimum at such time, as soon as possible and in any event not later than the 75th day after such date.


 


(c)       The
Company shall, if applicable: (i) in the time and manner required by the principal Trading Market, prepare and file with such
Trading Market an additional shares listing application covering a number of shares of Common Stock at least equal to the Required
Minimum on the date of such application, (ii) take all steps necessary to cause such shares of Common Stock to be approved for
listing or quotation on such Trading Market as soon as possible thereafter, (iii) provide to the Holders evidence of such listing
or quotation and (iv) maintain the listing or quotation of such Common Stock on any date at least equal to the Required Minimum
on such date on such Trading Market or another Trading Market. The Company agrees to maintain the eligibility of the Common Stock
for electronic transfer through the Depository Trust Company or another established clearing corporation, including, without limitation,
by timely payment of fees to the Depository Trust Company or such other established clearing corporation in connection with such
electronic transfer.


 




    	 	11	 



    	 



    

 


4.9       Subsequent
Equity Sales.


 


(a)       From
the date hereof until 9 months following the Closing Date, the Company shall be prohibited from effecting or entering into an
agreement to effect any issuance by the Company (or any direct or indirect subsidiaries the Company may obtain or form in the
future) of Common Stock or Common Stock Equivalents (or a combination of units thereof) involving a Variable Rate Transaction.
“Variable Rate Transaction” means a transaction in which the Company (i) issues or sells any debt or equity
securities that are convertible into, exchangeable or exercisable for, or include the right to receive, additional shares of Common
Stock either (A) at a conversion price, exercise price or exchange rate or other price that is based upon, and/or varies with,
the trading prices of or quotations for the shares of Common Stock at any time after the initial issuance of such debt or equity
securities or (B) with a conversion, exercise or exchange price that is subject to being reset at some future date after the initial
issuance of such debt or equity security or upon the occurrence of specified or contingent events directly or indirectly related
to the business of the Company or the market for the Common Stock or (ii) enters into, or effects a transaction under, any agreement,
including, but not limited to, an equity line of credit, whereby the Company may issue securities at a future determined price.
Any Holder shall be entitled to obtain injunctive relief against the Company to preclude any such issuance, which remedy shall
be in addition to any right to collect damages.


 


(b)       Notwithstanding
the foregoing, this Section 4.13 shall not apply in respect of an Exempt Issuance, except that no Variable Rate Transaction shall
be an Exempt Issuance. “Exempt Issuance” means the issuance of (a) shares of Common Stock, Restricted Stock
Units (RSUs) or options to eligible grantees under 2015 Omnibus Incentive and Securities Plan, provided that issuances under this
clause (a) shall not exceed an aggregate of twenty percent (20%) of the total outstanding shares of Common Stock on an as converted
primary basis as of the date hereof in any 12 month period, (b) securities upon the exercise or exchange of or conversion of any
securities issued hereunder and/or other securities exercisable or exchangeable for or convertible into shares of Common Stock
issued and outstanding on the date of this Agreement, provided that such securities have not been amended since the date of this
Agreement to increase the number of such securities or to decrease the exercise price, exchange price or conversion price of such
securities (other than in connection with stock splits or combinations) or to extend the term of such securities, (c) securities
issued pursuant to acquisitions or strategic transactions approved by a majority of the disinterested directors of the Company,
provided that any such issuance shall only be to a Person (or to the equityholders of a Person) which is, itself or through its
subsidiaries, an operating company or an owner of an asset in a business synergistic with the business of the Company and shall
provide to the Company additional benefits in addition to the investment of funds, but shall not include a transaction in which
the Company is issuing securities primarily for the purpose of raising capital or to an entity whose primary business is investing
in securities, and (d) shares of Common Stock issued in lieu of cash payment for services provided by service providers.


 




    	 	12	 



    	 



    

 


4.10       Most
Favored Nation Provision.


 


(a)       From
the date hereof until the date when the Holder no longer holds Debentures originally purchased by the Holder hereunder, if the
Company effects a Subsequent Financing, each Holder may elect, in its sole discretion, to exchange all or some of the Debentures
then held by the Holder for any securities or units issued in a Subsequent Financing on a $1.00 for $1.00 basis based on the outstanding
principal amount of such Debentures, along with any accrued but unpaid interest (including guaranteed interest in the first year),
liquidated damages and other amounts owing thereon, and the effective price at which such securities were sold in such Subsequent
Financing; provided, however, that this Section 4.10 shall not apply with respect to an Exempt Issuance. The Company
shall provide each Holder with notice of any such Subsequent Financing in the manner set forth below. “Subsequent Financing”
shall mean any issuance by the Company (or any direct or indirect subsidiaries the Company may obtain or form in the future) of
Common Stock or Common Stock Equivalents or indebtedness (or a combination of units thereof).


 


(b)       At
least five (5) Trading Days prior to the closing of the Subsequent Financing, the Company shall deliver to the Holder a written
notice of its intention to effect a Subsequent Financing (“Pre-Notice”), which Pre-Notice shall ask the Holder
if it wants to review the details of such financing (such additional notice, a “Subsequent Financing Notice”).
Upon the request of the Holder, and only upon a request by the Holder, for a Subsequent Financing Notice, the Company shall promptly,
but no later than one (1) Trading Day after such request, deliver a Subsequent Financing Notice to the Holder. The Subsequent
Financing Notice shall describe in reasonable detail the proposed terms of such Subsequent Financing, the amount of proceeds intended
to be raised thereunder and the Person or Persons through or with whom such Subsequent Financing is proposed to be effected and
shall include a term sheet or similar document relating thereto as an attachment. If the Holder wishes to exchange any part of
the Debenture pursuant to this Section 4.10, the Holder must provide written notice to the Company by not later than 5:30 p.m.
(New York City time) on the fifth (5th) Trading Day after the Holder has received the Pre-Notice that the Holder desires to exchange
it Debenture and the amount of the Debenture that the Holder desires to exchange. If the Company receives no such notice from
the Holder as of such fifth (5th) Trading Day, the Holder shall be deemed to have notified the Company that it does not elect
to exchange its Debenture. Notwithstanding anything to the contrary in this Section 4.10 and unless otherwise agreed to by the
Holder, the Company shall either confirm in writing to the Holder that the transaction with respect to the Subsequent Financing
has been abandoned or shall publicly disclose its intention to issue the securities in the Subsequent Financing, in either case
in such a manner such that the Holder will not be in possession of any material, non-public information, by the tenth (10th)
Business Day following delivery of the Subsequent Financing Notice. If by such tenth (10th) Business Day, no public
disclosure regarding a transaction with respect to the Subsequent Financing has been made, and no notice regarding the abandonment
of such transaction has been received by the Holder, such transaction shall be deemed to have been abandoned and the Holder shall
not be deemed to be in possession of any material, non-public information with respect to the Company (or any direct or indirect
subsidiaries the Company may obtain or form in the future).


 


4.12       Capital
Changes. Until the date that the Debentures are no longer outstanding, other than in connection with a listing of the Common
Stock on a national securities exchange, the Company shall not undertake a reverse or forward stock split or reclassification
of the Common Stock without the prior written consent of the Holder or as otherwise provided in the Transaction Documents.


 




    	 	13	 



    	 



    

 


4.13       Acknowledgment
of Dilution. The Company acknowledges that the issuance of the Securities may result in dilution of the outstanding shares
of Common Stock, which dilution may be substantial under certain market conditions. The Company further acknowledges that its
obligations under the Transaction Documents, including, without limitation, its obligation to issue the Underlying Shares pursuant
to the Transaction Documents, are unconditional and absolute and not subject to any right of set off, counterclaim, delay or reduction,
regardless of the effect of any such dilution or any claim the Company may have against the Holder and regardless of the dilutive
effect that such issuance may have on the ownership of the other stockholders of the Company.


 


4.14       Furnishing
of Information. Until the earliest of the time that no Holder owns Securities, the Company covenants to maintain the registration
of the Common Stock under Section 12(b) or 12(g) of the Exchange Act and to timely file (or obtain extensions in respect thereof
and file within the applicable grace period) all reports required to be filed by the Company after the date hereof pursuant to
the Exchange Act even if the Company is not then subject to the reporting requirements of the Exchange Act.


 


4.15       Integration.
The Company shall not sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined
in Section 2 of the Securities Act) that would be integrated with the offer or sale of the Securities in a manner that would require
the registration under the Securities Act of the sale of the Securities or that would be integrated with the offer or sale of
the Securities for purposes of the rules and regulations of any Trading Market such that it would require shareholder approval
prior to the closing of such other transaction unless shareholder approval is obtained before the closing of such subsequent transaction.


 


ARTICLE
V.


MISCELLANEOUS


 


5.1       Termination.
This Agreement may be terminated by any Holder, as to the Holder’s obligations hereunder only and without any effect whatsoever
on the obligations between the Company and the other Holder, by written notice to the other parties, if the Closing has not been
consummated on or before May __, 2017; provided, however, that such termination will not affect the right of any
party to sue for any breach by the other party (or parties).


 


5.2       Fees
and Expenses. The Company shall be responsible for all reasonable fees and expenses of the Purchaser, including, but not limited
to, legal and due diligence fees and expenses. Except as expressly set forth in the Transaction Documents to the contrary, each
party shall pay the fees and expenses of its advisers, counsel, accountants and other experts, if any, and all other expenses
incurred by such party incident to the negotiation, preparation, execution, delivery and performance of this Agreement. The Company
shall pay all Transfer Agent fees (including, without limitation, any fees required for same-day processing of any instruction
letter delivered by the Company and any conversion or exercise notice delivered by the Purchaser), stamp taxes and other taxes
and duties levied in connection with the delivery of any Securities to the Purchaser.


 




    	 	14	 



    	 



    

 


5.3       Entire
Agreement. The Transaction Documents, together with the exhibits and schedules thereto, contain the entire understanding of
the parties with respect to the subject matter hereof and thereof and supersede all prior agreements, and understandings, oral
or written, with respect to such matters, which the parties acknowledge have been merged into such documents, exhibits and schedules.


 


5.4       Notices.
Any and all notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and
shall be deemed given and effective on the earliest of: (a) the date of transmission, if such notice or communication is delivered
via facsimile at the facsimile number or email attachment as set forth on the signature pages attached hereto at or prior to 5:30
p.m. (New York City time) on a Trading Day, (b) the next Trading Day after the date of transmission, if such notice or communication
is delivered via facsimile at the facsimile number or email attachment as set forth on the signature pages attached hereto on
a day that is not a Trading Day or later than 5:30 p.m. (New York City time) on any Trading Day, (c) the second (2nd)
Trading Day following the date of mailing, if sent by U.S. nationally recognized overnight courier service or (d) upon actual
receipt by the party to whom such notice is required to be given. The address for such notices and communications shall be as
set forth on the signature pages attached hereto. To the extent that any notice provided pursuant to any Transaction Document
constitutes, or contains, material, non-public information regarding the Company or any direct or indirect subsidiaries the Company
may obtain or form in the future, the Company shall simultaneously file such notice with the Commission pursuant to a Current
Report on Form 8-K.


 


5.5       Amendments;
Waivers. No provision of this Agreement may be waived, modified, supplemented or amended except in a written instrument signed,
in the case of an amendment, by the Company and the Purchaser. No waiver of any default with respect to any provision, condition
or requirement of this Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default
or a waiver of any other provision, condition or requirement hereof, nor shall any delay or omission of any party to exercise
any right hereunder in any manner impair the exercise of any such right. Any amendment effected in accordance with accordance
with this Section 5.5 shall be binding upon the Purchaser and holder of Securities and the Company.


 


5.6       Headings.
The headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to limit or affect
any of the provisions hereof.


 


5.7       Successors
and Assigns. This Agreement shall be binding upon and inure to the benefit of the parties and their successors and permitted
assigns. The Company may not assign this Agreement or any rights or obligations hereunder without the prior written consent of
the Purchaser (other than by merger). The Purchaser may assign any or all of its rights under this Agreement to any Person to
whom such Purchaser assigns or transfers any Securities, provided that such transferee agrees in writing to be bound, with respect
to the transferred Securities, by the provisions of the Transaction Documents that apply to the “Purchaser.”


 




    	 	15	 



    	 



    

 


5.8       Governing
Law. All questions concerning the construction, validity, enforcement and interpretation of the Transaction Documents shall
be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the
principles of conflicts of law thereof. Each party agrees that all legal Proceedings concerning the interpretations, enforcement
and defense of the transactions contemplated by this Agreement and any other Transaction Documents (whether brought against a
party hereto or its respective affiliates, directors, officers, shareholders, partners, members, employees or agents) shall be
commenced exclusively in the state and federal courts sitting in the City of New York. Each party hereby irrevocably submits to
the exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan for the adjudication
of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein (including
with respect to the enforcement of any of the Transaction Documents), and hereby irrevocably waives, and agrees not to assert
in any Action or Proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such Action
or Proceeding is improper or is an inconvenient venue for such Proceeding. Each party hereby irrevocably waives personal service
of process and consents to process being served in any such Action or Proceeding by mailing a copy thereof via registered or certified
mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices to it under this Agreement
and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein
shall be deemed to limit in any way any right to serve process in any other manner permitted by law. If any party hereto shall
commence an Action or Proceeding to enforce any provisions of the Transaction Documents, then, in addition to the obligations
of the Company under Section 4.3, the prevailing party in such Action or Proceeding shall be reimbursed by the non-prevailing
party for its reasonable attorneys’ fees and other costs and expenses incurred with the investigation, preparation and prosecution
of such Action or Proceeding.


 


5.10       Survival.
The representations and warranties contained herein shall survive the Closing and the delivery of the Securities.


 


5.11       Execution.
This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one and the same
agreement and shall become effective when counterparts have been signed by each party and delivered to the other party, it being
understood that both parties need not sign the same counterpart. In the event that any signature is delivered by facsimile transmission
or by e-mail delivery of a “.pdf” format data file, such signature shall create a valid and binding obligation of
the party executing (or on whose behalf such signature is executed) with the same force and effect as if such facsimile or “.pdf”
signature page were an original thereof.


 


5.12       Severability.
If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction to be invalid,
illegal, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions set forth herein shall remain
in full force and effect and shall in no way be affected, impaired or invalidated, and the parties hereto shall use their commercially
reasonable efforts to find and employ an alternative means to achieve the same or substantially the same result as that contemplated
by such term, provision, covenant or restriction. It is hereby stipulated and declared to be the intention of the parties that
they would have executed the remaining terms, provisions, covenants and restrictions without including any of such that may be
hereafter declared invalid, illegal, void or unenforceable.


 




    	 	16	 



    	 



    

 


5.13       Rescission
and Withdrawal Right. Notwithstanding anything to the contrary contained in (and without limiting any similar provisions of)
any of the other Transaction Documents, whenever the Purchaser exercises a right, election, demand or option under a Transaction
Document and the Company does not timely perform its related obligations within the periods therein provided, then the Purchaser
may rescind or withdraw, in its sole discretion from time to time upon written notice to the Company, any relevant notice, demand
or election in whole or in part without prejudice to its future actions and rights; provided, however, that in the
case of a rescission of a conversion of a Debenture or Preferred Stock, the Purchaser shall be required to return any shares of
Common Stock subject to any such rescinded conversion or exercise notice concurrently with the return to the Purchaser of the
aggregate exercise price paid to the Company for such shares and the restoration of such Purchaser’s right to acquire such
shares pursuant to such Purchaser’s Preferred Stock (including, issuance of a replacement certificate evidencing such restored
right).


 


5.14       Replacement
of Securities. If any certificate or instrument evidencing any Securities is mutilated, lost, stolen or destroyed, the Company
shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof (in the case of mutilation),
or in lieu of and substitution therefor, a new certificate or instrument, but only upon receipt of evidence reasonably satisfactory
to the Company of such loss, theft or destruction. The applicant for a new certificate or instrument under such circumstances
shall also pay any reasonable third-party costs (including customary indemnity) associated with the issuance of such replacement
Securities.


 


5.15       Remedies.
In addition to being entitled to exercise all rights provided herein or granted by law, including recovery of damages, the Purchaser
and the Company will be entitled to specific performance under the Transaction Documents. The parties agree that monetary damages
may not be adequate compensation for any loss incurred by reason of any breach of obligations contained in the Transaction Documents
and hereby agree to waive and not to assert in any Action for specific performance of any such obligation the defense that a remedy
at law would be adequate


 


5.16       Usury.
To the extent it may lawfully do so, the Company hereby agrees not to insist upon or plead or in any manner whatsoever claim,
and will resist any and all efforts to be compelled to take the benefit or advantage of, usury laws wherever enacted, now or at
any time hereafter in force, in connection with any Action or Proceeding that may be brought by the Purchaser in order to enforce
any right or remedy under any Transaction Document. Notwithstanding any provision to the contrary contained in any Transaction
Document, it is expressly agreed and provided that the total liability of the Company under the Transaction Documents for payments
in the nature of interest shall not exceed the maximum lawful rate authorized under applicable law (the “Maximum Rate”),
and, without limiting the foregoing, in no event shall any rate of interest or default interest, or both of them, when aggregated
with any other sums in the nature of interest that the Company may be obligated to pay under the Transaction Documents exceed
such Maximum Rate. It is agreed that if the maximum contract rate of interest allowed by law and applicable to the Transaction
Documents is increased or decreased by statute or any official governmental action subsequent to the date hereof, the new maximum
contract rate of interest allowed by law will be the Maximum Rate applicable to the Transaction Documents from the effective date
thereof forward, unless such application is precluded by applicable law. If under any circumstances whatsoever, interest in excess
of the Maximum Rate is paid by the Company to any Purchaser with respect to indebtedness evidenced by the Transaction Documents,
such excess shall be applied by the Purchaser to the unpaid principal balance of any such indebtedness or be refunded to the Company,
the manner of handling such excess to be at the Purchaser’s election.


 




    	 	17	 



    	 



    

 


5.18       Liquidated
Damages. The Company’s obligations to pay any partial liquidated damages or other amounts owing under the Transaction
Documents is a continuing obligation of the Company and shall not terminate until all unpaid partial liquidated damages and other
amounts have been paid notwithstanding the fact that the instrument or security pursuant to which such partial liquidated damages
or other amounts are due and payable shall have been canceled.


 


5.19       Saturdays,
Sundays, Holidays, etc.If the last or appointed day for the taking of any action or the expiration of any right required
or granted herein shall not be a Business Day, then such action may be taken or such right may be exercised on the next succeeding
Business Day.


 


5.20       Construction.
The parties agree that each of them and/or their respective counsel has reviewed and had an opportunity to revise this Agreement
and, therefore, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party
shall not be employed in the interpretation of this Agreement or any amendments hereto. In addition, each and every reference
to share prices and shares of Common Stock in any Transaction Document shall be subject to adjustment for reverse and forward
stock splits, stock dividends, stock combinations and other similar transactions of the Common Stock that occur after the date
of this Agreement.


 


5.21       WAIVER
OF JURY TRIAL. IN ANY ACTION, SUIT, OR PROCEEDING IN ANY JURISDICTION BROUGHT BY ANY PARTY AGAINST ANY OTHER PARTY, THE PARTIES
EACH KNOWINGLY AND INTENTIONALLY, TO THE GREATEST EXTENT PERMITTED BY APPLICABLE LAW, HEREBY ABSOLUTELY, UNCONDITIONALLY, IRREVOCABLY
AND EXPRESSLY WAIVES FOREVER TRIAL BY JURY. 


 


(Signature
Pages Follow)


 




    	 	18	 



    	 



    

 


IN
WITNESS WHEREOF, the parties hereto have caused this Securities Exchange Agreement to be duly executed by their respective authorized
signatories as of the date first indicated above.


 


	advanced
    medical isotope corporation	Address
    for Notice:
	 	 	 
	By:	 	
	Name:
    	Michael
    Korenko	719
    Jadwin Avenue, Richland, WA 99352
	Title:	CEO	MKorenko@IsotopeWorld.com
	 	 	Bjolliff@IsotopeWorld.com
	With
    a copy to (which shall not constitute notice):	509-736-4000
    office


 


[REMAINDER
OF PAGE INTENTIONALLY LEFT BLANK


SIGNATURE
PAGE FOR HOLDER FOLLOWS]


 




    	 	19	 



    	 



    

 


[HOLDER
SIGNATURE PAGES TO ADMD SECURITIES EXCHANGE AGREEMENT]


 


IN
WITNESS WHEREOF, the undersigned have caused this Securities Exchange Agreement to be duly executed by their respective authorized
signatories as of the date first indicated above.


 


Name
of Holder: __________________


 


Signature
of Authorized Signatory of Holder: __________________________


 


Name
of Authorized Signatory: ____________________________________


 


Title
of Authorized Signatory: _____________________________________


 


Email
Address of Authorized Signatory: ___________________________________________


 


Facsimile
Number of Authorized Signatory: _________________________________________


 


Address
for Notice of Holder:


 


[SIGNATURE
PAGES CONTINUE]


 




    	 	20