EX-10.13



 Exhibit 10.13 

AMENDED AND RESTATED EMPLOYMENT AGREEMENT 

This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (“Agreement”) is made and entered into as of
December 7, 2015, by and between William J. Enright (“Enright”) and Altimmune Inc. (f/k/a Vaxin, Inc.), a Delaware corporation (“Altimmune”). This Agreement will become effective upon the date of the
underwriting agreement between Altimmune and the underwriter(s) managing the initial public offering of Altimmune’s common stock (the “IPO”), pursuant to which such common stock is priced for the IPO (the “Effective
Date”); provided that if (i) Altimmune does not complete an IPO on or prior to the one year anniversary of the date hereof or (b) Enright does not remain continuously employed by Altimmune from the date hereof through the
Effective Date, this Agreement shall be void ab initio (i.e., it shall never take effect) and the Prior Employment Agreement (as defined below) shall remain in full force and effect. 

WHEREAS, Enright currently serves as the President and Chief Executive Officer of Altimmune pursuant to that certain Employment
Agreement, by and between Enright and Altimmune, effective as of June 27, 2008 (the “Prior Employment Agreement”); 

WHEREAS, the Board of Directors of Altimmune (the “Board”) or an authorized committee thereof and Enright desire to
terminate and supersede the Prior Employment Agreement as of the Effective Date pursuant to the terms hereof to assure Altimmune of Enright’s continued employment in an executive capacity and to compensate him therefor; 

WHEREAS, the Board considers the establishment and maintenance of a sound management to be essential to protecting and enhancing the
best interests of Altimmune and its stockholders; 
 WHEREAS, the Board has determined that appropriate steps should be taken to
retain Enright and to reinforce and encourage his continued attention and dedication to his assigned duties and Altimmune desires to retain the services of Enright, and Enright desires to be employed by Altimmune pursuant to the terms and conditions
set forth in this Agreement; 
 WHEREAS, Altimmune and Enright both acknowledge that there is no assurance that Altimmune will
complete an IPO on or prior to the first anniversary of the date hereof or at all at any time and that if it does not, the Effective Date will not occur and this Agreement will not take effect; and 

WHEREAS, Enright acknowledges that, in executing this Agreement, he has had a reasonable opportunity to seek the advice of independent
legal and tax counsel, and has read and understood all of the terms and provisions of this Agreement. 







 NOW, THEREFORE, in consideration of the mutual promises and covenants contained herein and
for other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the parties hereto agree as follows: 

1. Titles, Duties and Responsibilities. 

(a) Title and Duties. During the Employment Period (as defined in Section 2 below), Enright shall serve as President and Chief
Executive Officer of Altimmune and shall have such duties, responsibilities and authority commensurate with such position, and such additional duties and responsibilities commensurate with such position as shall be determined from time to time by
the Board. During the Employment Period, subject to the requirements of any applicable law (including, without limitation, any rules or regulations of any exchange on which the common stock of Altimmune is then listed or traded), Altimmune agrees to
use its best efforts to cause Enright to be nominated for election (or re-election) at each annual meeting at which the class of directors of which Enright is a part is subject to election (or re-election). If requested, Enright shall also serve
without additional compensation in such other offices of Altimmune or its subsidiaries or affiliates to which he may be elected or appointed. 

(b) Reporting Responsibilities. Enright shall report directly to the Board. 

(c) Conflicts of Interest and Compliance with Laws. Except as specifically set forth in this Section 1(c), during the Employment
Period, Enright shall devote his entire time, attention, energies and business efforts to the affairs of Altimmune. Except as set forth below, during the Employment Period, Enright shall not, without the prior written consent of the Board
(x) engage, directly or indirectly, in any other business activity that materially interferes with his duties as set forth in this Agreement and/or that creates a conflict of interest, (y) act as a proprietor, partner, director, officer,
executive, consultant, advisor, agent, representative or any other capacity of any entity other than Altimmune and its divisions, subsidiaries and other affiliated entities, regardless of whether such activity is for gain, profit or other pecuniary
advantage, or (z) allow or cause Altimmune to participate in any transaction with Enright, any of his relatives (other than as employees of Altimmune), or any entity in which Enright or any of his relatives has an interest. Enright further
agrees that he shall not knowingly take any action, or authorize the taking of any action, that contravenes any applicable federal, state, municipal or other political subdivision ordinance, statute or rule, regulation or order of any jurisdiction.
Enright agrees to immediately disclose to the Board any relationship, action or activity that may potentially be subject to the provisions of this Section 1(c). Notwithstanding any restrictions contained in this Section 1(c), it is
expressly understood and agreed that Enright serves and may continue to serve on the Johns Hopkins University Carey Business School Dean’s Alumni Advisory Board and the Johns Hopkins University Alumni Council, in each case, for so long as such
service does not materially interfere with the performance of his duties and responsibilities hereunder or does not give rise to a conflict of interest. 

2. Employment Term. Unless sooner terminated as provided elsewhere in this Agreement, Enright’s employment with Altimmune
under this Agreement shall begin on the Effective Date and end at 11:59 p.m. Eastern Time on December 31, 2017 (the “Initial Employment Period”). Commencing on January 1, 2018 and each January 1 thereafter (the
“Extension Date”), this Agreement shall automatically renew on the terms and conditions as then in effect for additional successive periods of one (1) year unless terminated by either party upon written notice to the other
party not less than ninety (90) days prior to the Extension Date. The Initial Employment Period and any extension or renewal thereof shall be referred to herein together as the “Employment Period.” Notwithstanding anything to
the contrary contained herein, the Employment Period is subject to termination pursuant to Section 6 hereof. 

  
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 3. Salary, Bonus and Other Compensation. During Enright’s employment,
Altimmune shall provide the following salary, bonus and other compensation to Enright: 
 (a) Base Compensation. Altimmune
shall pay Enright an initial annual base salary of Three Hundred Seventy-Five Thousand Dollars ($375,000) per annum (“Base Salary”), payable in substantially equal installments in accordance with Altimmune’s normal payroll
practices. Enright’s compensation shall be evaluated and adjusted by the Compensation Committee of the Board (the “Committee”) on at least an annual basis, provided that in no event shall Enright’s Base Salary be reduced
while this Agreement is in effect. 
 (b) Annual Bonus. In addition to the Base Salary, during each year of the Employment Period,
Enright will be eligible for an annual cash bonus (“Annual Bonus”) with a target award equal to fifty percent (50%) of the Base Salary. The Annual Bonus will be subject to all of the terms and conditions of the applicable
bonus plan. The actual Annual Bonus payouts will be based on achievement of the individual and/or company performance criteria established for the applicable fiscal year by the Committee in its sole and absolute discretion. Enright must be actively
employed on December 31st of the applicable fiscal year to be eligible for an Annual Bonus payment. The Annual Bonus shall be paid no later than the March 15th of the fiscal year immediately following the fiscal year in which such Annual Bonus was earned. 

(c) IPO Option Award. Subject to the approval of the Committee, Altimmune shall grant Enright an option to purchase 133,395 shares of
Altimmune’s common stock (the “IPO Option”) under the Altimmune, Inc. 2016 Omnibus Incentive Plan (the “2016 Plan”) on the Effective Date. The exercise price of the IPO Option shall be equal to the initial
public offering price per share of Altimmune’s common stock on the Effective Date. One hundred percent (100%) of the IPO Option shall be unvested and unexercisable as of the Effective Date. Commencing on the first anniversary of the
Effective Date, twenty-five percent (25%) of the unvested portion of the IPO Option shall vest and become exercisable, and the aggregate remaining unvested portion of the IPO Option shall vest and become exercisable in equal monthly
installments over the thirty-six (36) month period following such anniversary date. Notwithstanding the foregoing, if the Committee, in its sole discretion, determines that the IPO was successful, 50% of the unvested portion of the IPO Option
shall immediately vest and become exercisable. For the avoidance of doubt, the Committee shall have the sole and absolute discretion to determine whether the IPO was successful for purposes of the immediately preceding sentence. Other than as set
forth in this Section 3(c), the IPO Option will be governed by the terms and conditions of the 2016 Plan and the stock option agreement approved by the Committee to evidence the grant of the IPO Option. 

(d) Additional Equity Awards. Enright will be entitled to participate in the 2016 Plan or such other equity based long-term incentive
compensation plan, program or arrangement generally made available to senior executive officers of Altimmune from time to time, as determined by the Committee in its sole and absolute discretion. 

  
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 4. Benefits. During the Employment Period, Enright shall be eligible for
participation in and shall receive all benefits under welfare benefit, savings and retirement plans provided by Altimmune (including, but not limited to, life insurance, disability insurance, medical insurance, dental insurance) to the extent
applicable generally to senior executives of Altimmune, and consistent with the following specific agreements: 
 (a) Vacation.
Enright will be entitled to twenty (20) days of paid vacation and six (6) days of personal and sick leave each year during the Employment Period. Enright is permitted to carry over a maximum of twelve (12) days of personal and sick
leave per year, subject to applicable law. 
 (b) Health, Life, Vision and Disability Insurance 

(i) Enright will be entitled to participate in all health, vision and dental insurance programs provided by Altimmune to the extent applicable
generally to senior executives of Altimmune. Altimmune will pay all premiums for Enright and his family during the term this Agreement is in effect. 

(ii) During Enright’s employment with Altimmune, Altimmune shall provide Enright with term life insurance with a death benefit equal to
Enright’s Base Salary (subject to insurability). 
 (iii) Subject to Enright’s insurability, during Enright’s employment with
Altimmune, Altimmune shall maintain, at its cost, renewable short-term and long-term disability plans that provide for the annual payment of not less than 60% of Enright’s Base Salary for so long as any short-term and/or long-term disability of
Enright continues. 
 (c) During Enright’s employment with Altimmune, Altimmune shall maintain D&O insurance at Altimmune’s
expense and shall name Enright as an additional insured. 
 5. Reimbursement of Business Expenses. Altimmune shall reimburse
Enright for all reasonable and customary out-of-pocket business expenses incurred by Enright in the course of his duties (to include monthly expenses to maintain cellular telephone service), in accordance with Altimmune’s policies as in effect
from time to time. Enright shall be required to submit to Altimmune appropriate documentation supporting such out-of-pocket business expenses as a prerequisite to reimbursement in accordance with such policies. Notwithstanding anything herein to the
contrary or otherwise, except to the extent any expense or reimbursement described in this Agreement does not constitute a “deferral of compensation” within the meaning of Section 409A of the Code and the Treasury regulations and
other guidance issued thereunder, any expense or reimbursement described in this Agreement shall meet the following requirements: (i) the amount of expenses eligible for reimbursement provided to Enright during any calendar year will not affect
the amount of expenses eligible for reimbursement to Enright in any other calendar year; (ii) the reimbursements for expenses for which Enright is entitled to be reimbursed shall be made on or before the last day of the calendar year following
the calendar year in which the applicable expense is incurred; (iii) the right to payment or reimbursement or in-kind benefits hereunder may not be liquidated or exchanged for any other benefit; and (iv) the reimbursements shall be made
pursuant to objectively determinable and nondiscretionary company policies and procedures regarding such reimbursement of expenses. 

  
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 6. Termination Provisions. 

(a) Termination by Altimmune for Cause or Termination by Enright without Good Reason. Altimmune may terminate Enright’s employment
immediately for Cause (as defined below) and Enright may terminate his employment at any time without Good Reason upon providing Altimmune at least thirty (30) days advance written notice. Upon such termination, Altimmune shall provide
Enright with the following: (i) payment of any accrued Base Salary through and including the date of Enright’s termination to the extent not theretofore paid; (ii) any accrued and unused vacation pay through and including the date of
Enright’s termination; (iii) any unreimbursed business expenses in accordance with Section 5 hereof, and (iv) such accrued and vested rights or benefits as may be due to Enright under any Altimmune sponsored employee benefits
plans payable in accordance with the terms and conditions of such plans (the payments and benefits referred to in subclauses (i) through (iv) above shall be collectively referred to as the “Accrued Obligations”). Except as
provided in this Section 6(a), termination pursuant to this Section 6(a) shall terminate any other rights Enright may have under this Agreement and shall relieve Altimmune of any other obligations it may have under this Agreement. 

For purposes of this Agreement, termination for Cause shall mean the termination of Enright’s employment by Altimmune due to: (i) a
material breach by Enright of his fiduciary duties to Altimmune; (ii) a material breach by Enright of this Agreement after being given written notice of such breach and a failure to cure within thirty (30) days of such notice;
(iii) Enright’s willful failure or refusal to follow Altimmune’s written policies after being given written notice of said failure or refusal and a failure to cure within thirty (30) days of such notice; (iv) Enright’s
conviction of, or plea of guilty or nolo contendere, to a felony; and/or (v) Enright’s continuing and willful refusal to act as directed by the Board (other than refusal resulting from incapacity due to physical or mental illness),
after written notice is delivered to Enright within sixty (60) days of such refusal which identifies said refusal and sets forth a plan of corrective action and a failure to cure within thirty (30) days of such notice. 

(b) Termination by Altimmune without Cause or Resignation by Enright for Good Reason. Altimmune may terminate Enright’s employment
without Cause at any time upon prior written notice to Enright and Enright may terminate his employment for Good Reason (as defined below). Upon such termination, subject to Enright’s continued compliance with the restrictive covenants set
forth in Section 7, Altimmune shall provide Enright with the following: 
 (i) continued payment of the Cash Severance Amount (as
defined below) in twelve (12) equal monthly installments following the effective date of such termination and otherwise payable in accordance with Altimmune’s normal payroll practices. As used herein, the “Cash Severance
Amount” shall be equal to 12 months of Enright’s Base Salary existing at the time of such termination, except that if such termination occurs within the one (1) year period commencing on the occurrence of a Change in Control (as
defined below), the Cash Severance Amount shall instead be equal to the sum of 18 months of Enright’s Base Salary (existing at the time of such termination) plus Enright’s target Annual Bonus for the year of termination; 

  
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 (ii) subject to Enright’s timely election, and the availability, of continuation coverage
under Part 6 of Title I of the Employment Retirement Income Security Act of 1974 (as amended) and Section 4980B of the Code (“COBRA”), Altimmune will pay monthly, on Enright’s behalf, a portion of the cost of such coverage
for the twelve (12) months after the date of such termination, which payments will be equal to the amount of the monthly premium for such coverage, less the amount that Enright would have been required to pay if Enright had remained an active
employee of Altimmune (the “COBRA Assistance”); provided, however, if at any time Altimmune determines that the COBRA Assistance would result in a violation of the non-discrimination rules under Section 105(h)(2)
of the Internal Revenue Code of 1986, as amended (the “Code”) or any other applicable laws, statute or regulation of similar effect (including, but not limited to, the 2010 Patient Protection and Affordable Care Act, as amended by
the 2010 Health Care and Education Reconciliation Act), then in lieu of providing the COBRA Assistance, Altimmune will instead pay Enright fully taxable cash payments equal to, and paid at the same time as, the COBRA Assistance would have otherwise
been paid, subject to applicable tax withholdings; 
 (iii) any unpaid prior year’s Annual Bonus, payable by Altimmune to Enright at
the same time annual bonuses in respect of the prior year are generally paid to senior executives of Altimmune; 
 (iv) the Accrued
Obligations; and 
 (v) if such termination occurs within the one (1) year period commencing on the occurrence of a Change in Control,
accelerated vesting of all unvested equity awards then outstanding and held by Enright (for the avoidance of doubt, if such termination does not occur during such one (1) year period, then any accelerated vesting of unvested equity awards shall
be at the discretion of the Committee). 
 For purposes of this Agreement, resignation for Good Reason shall mean the resignation by Enright
of his employment due to: (a) a reduction in Enright’s Base Salary or target Annual Bonus opportunity; (b) a material diminution in Enright’s authority, duties or responsibilities; or (c) a relocation by Altimmune of
Enright’s principal place of business for the performance of his duties under this Agreement to a location that is anywhere outside of a 50-mile radius of Gaithersburg, Maryland; provided, however, that Enright must notify Altimmune within
ninety (90) days of the occurrence of any of the foregoing conditions that he considers to be a “Good Reason” condition and provide Altimmune with thirty (30) days in which to cure the condition. If Enright fails to provide this
notice and cure period prior to his resignation, or resigns more than six (6) months after the initial existence of the condition, his resignation will not be deemed to be for “Good Reason.” 

For purposes of this Agreement, “Change in Control” means the occurrence of either (i) an acquisition from stockholders
of Altimmune (including through purchase, reorganization, merger, consolidation or similar transaction), directly or indirectly, in one or more transactions by a Person (other than any Person or group of Persons consisting solely of shareholders of
Altimmune as of the date immediately prior to the consummation of the transaction) of beneficial ownership (within the meaning of Rule 13d-3 under the Exchange Act) of securities representing 50% or more of the combined voting power of the
securities of Altimmune entitled to vote generally in the election of directors of the Board, calculated on a fully diluted basis 

  
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after giving effect to such acquisition, or (ii) the sale or other disposition, directly or indirectly, of all or substantially all of the assets of Altimmune and its subsidiaries, taken as
a whole, to any Person (other than any Person or group of Persons consisting solely of shareholders of Altimmune as of the date immediately prior to the consummation of the transaction). For the avoidance of doubt, a transaction effected primarily
for the purpose of (x) an equity financing of Altimmune, (y) the reincorporation of Altimmune in a different state, or (z) the formation of a holding company that will be owned exclusively by Altimmune’s stockholders, shall not
be a Change in Control for purposes of this Agreement. A “Person” means any individual, entity or group within the meaning of Section 13(d)(3) or 14(d)(2) of the Securities Exchange Act of 1934, as amended, and the rules and
regulations thereunder, other than employee benefit plans sponsored or maintained by Altimmune and by entities controlled by Altimmune or an underwriter of the capital stock of Altimmune in a registered public offering. 

(c) Death or Disability. Enright’s employment shall terminate automatically upon Enright’s death. Subject to applicable law,
Altimmune may terminate Enright’s employment due to Enright’s Disability (as defined below). Upon any such termination, Altimmune shall provide Enright (or his estate as the case may be) with the Accrued Obligations through the date of
termination. The term “Disability” shall mean Enright becoming physically or mentally disabled such that he is unable to perform his duties to Altimmune for a period of 90 consecutive days. 

(d) Expiration of Employment Term. In the event notice of termination is provided by Enright in accordance with Section 2,
Enright’s employment shall terminate upon the expiration of the Employment Period. Upon such termination, Altimmune shall provide Enright with the Accrued Obligations through the date of termination and his Annual Bonus. 

(e) Limits. Notwithstanding anything herein to the contrary, Altimmune’s obligation to make any payments or benefits to Enright
upon termination of his employment under the circumstances described in Section 6(b) (other than the Accrued Obligations) and 6(d) (other than the Accrued Obligations) is conditioned upon Enright’s execution, delivery and
non-revocation of a valid and enforceable release of claims arising in connection with Enright’s employment and termination or resignation of employment with Altimmune and its affiliates (the “Release”) that becomes effective
not later than sixty (60) days after the date of such termination or resignation of employment. Altimmune shall provide the form of the Release to Enright within seven (7) days following the date of Enright’s termination or
resignation of employment. Subject to the foregoing and Section 21 hereof, the Cash Severance Amount will commence to be paid to Enright on the sixtieth (60th) day following Enright’s termination or resignation of employment, and such
first payment shall include payment of any amounts that would otherwise be due prior thereto. On any termination entitling Enright to the payments and benefits under Section 6(b) or 6(d), Altimmune and its affiliates shall have no further
obligation to make payments under this Agreement other than as specifically provided for in such section. 
 (f) Resignation from All
Positions. Unless the parties otherwise agree in writing, upon the termination or resignation of Enright’s employment with Altimmune for any reason, Enright shall be deemed to have resigned, as of the date of such termination or
resignation, from and with respect to all positions Enright then holds as an officer, director or employee with Altimmune and any of its affiliates. 

  
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 7. Secrecy, Non-Solicitation and Non-Competition. 

(a) Secrecy. During the Employment Period and thereafter, Enright covenants and agrees that he will not, except in performance of
Enright’s obligations to Altimmune, or with the prior written consent of Altimmune pursuant to the authority granted by a resolution of the Board, directly or indirectly, disclose any secret or confidential information that he may learn or has
learned by reason of his association with Altimmune or use any such information. The term “secret or confidential information” includes, without limitation, information not previously disclosed to the public or to the trade by
Altimmune’s management with respect to Altimmune’s products, facilities and methods, trade secrets and other intellectual property, systems, procedures, manuals, confidential reports, product price lists, customer lists, member lists,
financial information (including the revenues, costs or profits associated with any Altimmune’s products), business plans, prospects, employee or employees, compensation, or opportunities but shall exclude any information already in the public
domain which has been disclosed to the public during the normal course of Altimmune’s business. Notwithstanding anything herein to the contrary, nothing in this Agreement shall be construed to prohibit Enright from reporting possible violations
of federal or state law or regulations to any governmental agency or entity, including but not limited to the Department of Justice, the Securities and Exchange Commission, the Congress, and any agency Inspector General, or making other disclosures
that are protected under the whistleblower provisions of federal or state law or regulation. Enright does not need the prior authorization of Altimmune to make any such reports or disclosures and Enright is not required to notify Altimmune that he
made such reports or disclosures. 
 (b) Non-solicitation of Clients and Customers. Enright covenants and agrees that during the
Employment Period and for a period of one (1) year thereafter, he will not solicit, either directly or indirectly, any customer or client of Altimmune on behalf of any direct competitor of Altimmune for the purpose of diverting business from
Altimmune. This Agreement extends to prevent Enright from soliciting on behalf of Enright or any other individual or entity that seeks to compete with Altimmune. 

(c) Non-solicitation of Employees. Enright covenants and agrees that during the Employment Period and for a period of one (1) year
thereafter, he shall not directly or indirectly, on his behalf or on behalf of any person or other entity, solicit or induce, or attempt to solicit or induce, any person who is an employee of Altimmune, to terminate his or her employment with
Altimmune. 
 (d) Noncompetition. Enright covenants and agrees that during the Employment Period and for a period of one (1) year
thereafter, he will not directly or indirectly work for or engage in sales, marketing or related activities on behalf of himself or any other person or entity that is a direct competitor of Altimmune and that does any business in the same
geographical area as Altimmune; provided that in the event of a termination of Enright’s employment by Altimmune for Cause, the foregoing shall not apply after the end of the Employment Period. 

  
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 (e) Equitable Relief. Enright acknowledges and agrees that the services performed by him
are special, unique and extraordinary in that, by reason of Enright’s employment, Enright may acquire confidential information and trade secrets concerning the operation of Altimmune, or that Enright may have contact with or obtain knowledge of
Altimmune’s members or prospects, the use or disclosure of which could cause Altimmune substantial loss and damages, which could not be readily calculated and for which no remedy at law would be adequate. Accordingly, Enright acknowledges and
agrees that Altimmune shall be entitled to obtain a temporary restraining order and/or a preliminary or permanent injunction restraining Enright from engaging in activities prohibited by this Section 7 or such other relief as may be required to
specifically enforce any of the covenants in this Section 7. Enright acknowledges and agrees that Altimmune shall be entitled to its attorneys’ fees and court costs should Altimmune successfully pursue legal action to enforce its rights
under this Section 7. 
 (f) Return of Property. Upon termination or resignation of Enright’s employment with Altimmune,
Enright shall promptly supply to Altimmune all property, keys, notes, memoranda, writings, lists, files, reports, customer lists, correspondence, tapes, disks, cards, surveys, maps, logs, machines, technical data and any other tangible product or
document which has been produced by, received by or otherwise submitted to Enright during or prior to his employment with Altimmune, and any copies thereof in Enright’s (or capable of being reduced to Enright’s) possession. 

(g) Survival. Any termination of Enright’s employment, of the Employment Period or of this Agreement (or breach of this Agreement
by Altimmune or Enright) shall have no effect on the continuing operation of this Section 7. 
 8. Governing Law.
This Agreement is made and entered into in the State of Maryland, without regard to conflict of laws rules, and the laws of the State of Maryland shall govern its validity and interpretation in the performance by the parties of their respective
duties and obligations. 
 9. Entire Agreement. This Agreement constitutes the entire agreement between the parties with
respect to the matters described herein and supersedes all prior agreements and understandings both written and oral, among the parties with respect to the subject matter hereof (including, without limitation, the Prior Employment Agreement), and
there are no representation, warranties or commitments, other than those in writing executed by the parties hereto. 
 10.
Consent to Venue. Any dispute, controversy, or claim arising out of or relating to this Agreement or the breach thereof, arising out of or relating in any way to the employment of Enright or termination thereof, shall be brought in the
Federal courts located in the State of Maryland; provided, however, that if any of the aforementioned courts is found to lack subject matter jurisdiction, then to the exclusive jurisdiction of the state courts in the State of Maryland. By executing
and delivering this Agreement, each party, for itself or himself and in connection with its or his properties, irrevocably (a) accepts generally and unconditionally the exclusive jurisdiction and venue of such courts; (b) waives any
defense of forum non conveniens; (c) agrees that service of all process in any such proceeding in any such court may be made by registered or certified mail, return receipt requested, to the applicable party at its address
provided herein; and (d) agrees that service as provided in clause (c) above is sufficient to confer personal jurisdiction over the applicable party in any such proceeding in any such court, and otherwise constitutes effective and binding
service in every respect. 

  
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 11. WAIVER OF JURY TRIAL. EACH PARTY HERETO IRREVOCABLY AND UNCONDITIONALLY WAIVES
ANY RIGHT TO TRIAL BY JURY IN ANY DISPUTE, CONTROVERSY OR CLAIM, WHETHER SOUNDING IN CONTRACT, TORT OR OTHERWISE, AMONG THE PARTIES HERETO ARISING OUT OF OR RELATING IN ANY WAY TO THE EMPLOYMENT OF ENRIGHT OR TERMINATION THEREOF OR FOR ANY
COUNTERCLAIM THEREIN. THE PARTIES HERETO MAY FILE AN ORIGINAL COUNTERPART OR A COPY OF THIS AGREEMENT WITH ANY COURT OF COMPETENT JURISDICTION AS PROVIDED HEREIN AS WRITTEN EVIDENCE OF THE CONSENT OF THE PARTIES HERETO TO THE WAIVER OF THEIR RIGHT
TO TRIAL BY JURY. 
 12. Assistance in Litigation. Enright shall make himself available, upon the request of Altimmune,
to testify or otherwise assist in litigation, arbitration, or other disputes involving Altimmune, or any of the directors, officers, executives, subsidiaries, or parent corporations of Altimmune, at no additional cost during the Employment Period
and at any time following the termination of Enright’s employment for any reason; provided, however, in the event such request is made by Altimmune after the Employment Period, Enright shall be reimbursed for any reasonable out-of-pocket
expenses incurred with respect thereto and shall also be paid a reasonable daily stipend based on his Base Salary at the time of termination. 

13. Notices. Any notice or communication required or permitted to be given to the parties shall be delivered personally or sent
by registered or certified mail, postage prepaid and return receipt requested, and addressed or delivered as follows, or to such other address as the party addressed may have substituted by notice pursuant to this Section. 

 

	 	(a)	If to Altimmune, to: 

 Altimmune Inc. 

19 Firstfield Road, Suite 200 

Gaithersburg, Maryland 20878 

ATTN: Board of Directors 
  

	 	(b)	If to Enright, to: 

 The last address on file with Altimmune at the time of Notice. 

14. Binding Agreement. This Agreement shall inure to the benefit of and be enforceable by Enright and his personal or legal
representatives, executors, administrators, successors, heirs, distributees, devises and legatees. This Agreement shall inure to the benefit of and be enforceable by Altimmune and any of its successors and assigns. Altimmune will require any
successor (whether direct or indirect, by purchase, merger, consolidation or otherwise) to all or substantially all of the business and/or assets of Altimmune to assume expressly and agree to satisfy all of the obligations under this Agreement
in the same manner and to the same extent that Altimmune would be required to satisfy such obligations if no such succession had taken place. As used in this Agreement, “Altimmune” shall mean “Altimmune” as hereinbefore defined
and any successor to its respective businesses and/or assets as aforesaid which assumes and agrees to perform this Agreement by operation of law or otherwise. 

  
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 15. Amendment. This Agreement may not be amended or modified otherwise than by a
written agreement executed by Enright and the Chairman of the Board or their respective successors and legal representatives. 
 16.
Construction. This Agreement shall not be construed against any party by reason of the drafting or preparation hereof. 

17. Captions. The captions of this Agreement are inserted for convenience and are not part of the Agreement. 

18. Severability. In case any one or more of the provisions contained in this Agreement shall for any reason be held to be
invalid, illegal, or unenforceable in any other respect, such invalidity, illegality or unenforceability shall not affect any other provision of this Agreement. This Agreement shall be construed as if such invalid, illegal or unenforceable provision
had never been part of the Agreement and there shall be deemed substituted therefore such other provision as will most nearly accomplish the intent of the parties to the extent permitted by the applicable law. 

19. Survivorship. Upon the expiration or other termination of this Agreement or termination of Enright’s employment for any
reason, the respective rights and obligations of the parties hereto shall survive such expiration or other termination to the extent necessary to carry out the intentions of the parties under this Agreement. 

20. Withholding. Altimmune may withhold from any amounts payable under this Agreement such Federal, state, local or foreign taxes
as shall be required to be withheld pursuant to any applicable law or regulation. 
 21. Section 409A.  

(a) Although Altimmune does not guarantee the tax treatment of any payments or benefits provided under this Agreement, it is intended that this
Agreement will comply with, or be exempt from, Code Section 409A to the extent this Agreement (or any benefit or payment provided hereunder) is subject thereto, and this Agreement shall be interpreted on a basis consistent with such intent.

 (b) Notwithstanding any provision to the contrary in this Agreement, if Enright is deemed on the date of his “separation from
service” (within the meaning of Treas. Reg. Section 1.409A-1(h)) with Altimmune to be a “specified employee” (within the meaning of Treas. Reg. Section 1.409A-1(i)), then with regard to any payment or benefit that is
considered non-qualified deferred compensation under Code Section 409A payable on account of a “separation from service” that is required to be delayed pursuant to Code Section 409A(a)(2)(B) of the Code (after taking into account
any applicable exceptions to such requirement), such payment or benefit shall be made or provided on the date that is the earlier of (i) the date immediately following the expiration of the six-month period measured from the date of
Enright’s “separation from service,” and (ii) the date of Enright’s death (the “Delay Period”). Upon the expiration of the Delay Period, all payments and benefits delayed pursuant to this Section 21(b)
(whether they would have otherwise been payable in a single sum or in installments in the absence of such delay) shall be paid or reimbursed to Enright in a lump sum and any remaining payments and benefits due under this Agreement shall be paid or
provided in accordance with the normal payment dates specified for them herein. 

  
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 (c) Notwithstanding any provision of this Agreement to the contrary, for purposes of any
provision of this Agreement providing for the payment of any amounts or benefits upon or following a termination of employment that are considered deferred compensation under Code Section 409A, references to Enright’s “termination of
employment” (and corollary terms) with Altimmune shall be construed to refer to Enright’s “separation from service” (within the meaning of Treas. Reg. Section 1.409A-1(h)) with Altimmune. 

(d) Whenever payments under this Agreement are to be made in installments, each such installment shall be deemed to be a separate payment for
purposes of Code Section 409A. Whenever a payment under this Agreement specifies a payment period with reference to a number of days (e.g., “payment shall be made within thirty (30) days following the date of termination”), the
actual date of payment within the specified period shall be within the sole discretion of Altimmune. Notwithstanding anything herein, Enright shall be responsible for payment of any applicable personal tax liabilities associated with the receipt of
income or benefits pursuant to this Agreement. 
 22. Section 280G.  

(a) Notwithstanding anything contained in this Agreement to the contrary, (i) to the extent that any payment or distribution of any type
to or for the benefit of Enright by Altimmune, any affiliate thereof, any person or entity who acquires ownership or effective control of Altimmune or ownership of a substantial portion of Altimmune’s assets (within the meaning of
Section 280G of the Code and the regulations thereunder), or any affiliate of such person or entity, whether paid or payable or distributed or distributable pursuant to the terms of this Agreement or otherwise (the “Payments”)
constitutes “parachute payments” (within the meaning of Section 280G of the Code), and if (ii) such aggregate Payments would, if reduced by all federal, state and local taxes applicable thereto, including the excise tax imposed
under Section 4999 of the Code (the “Excise Tax”), be less than the amount Enright would receive, after all taxes, if Enright received aggregate Payments equal (as valued under Section 280G of the Code) to only three times
Enright’s “base amount” (within the meaning of Section 280G of the Code), less $1.00, then (iii) such Payments shall be reduced (but not below zero) if and to the extent necessary so that no Payments to be made or benefit to
be provided to Enright shall be subject to the Excise Tax; provided, however, that, solely to the extent applicable, Altimmune shall use its reasonable best efforts to obtain shareholder approval of the Payments provided for in this
Agreement in a manner intended to satisfy requirements of the “shareholder approval” exception to Section 280G of the Code and the regulations promulgated thereunder, such that payment may be made to Enright of such Payments without
the application of an Excise Tax. If the Payments are so reduced, Altimmune shall reduce or eliminate the Payments (x) by first reducing or eliminating the portion of the Payments which are not payable in cash (other than that portion of the
Payments subject to clause (z) hereof), (y) then by reducing or eliminating cash payments (other than that portion of the Payments subject to clause (z) hereof) and (z) then by reducing or eliminating the portion of the Payments
(whether payable in cash or not payable in cash) to which Treasury Regulation § 1.280G-1 Q/A 24(c) (or successor thereto) applies, in each case in reverse order beginning with payments or benefits which are to be paid the farthest in time. 


  
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 (b) The determination of whether the Payments shall be reduced as provided in Section 22(a)
hereof and the amount of such reduction shall be made at Altimmune’s expense by an independent public accounting firm of national reputation selected by Altimmune (the “Accounting Firm”). The Accounting Firm shall provide its
determination (the “Determination”), together with detailed supporting calculations and documentation, to Altimmune and Enright within ten (10) days after Enright’s final day of employment. If the Accounting Firm
determines that no Excise Tax is payable by Enright with respect to the Payments, it shall furnish Enright with an opinion reasonably acceptable to the him that no Excise Tax will be imposed with respect to any such payments and, absent manifest
error, such Determination shall be binding, final and conclusive upon Altimmune and Enright. 
 23. Special Indemnification.
Altimmune hereby agrees to hold harmless, defend, release and indemnify Enright against any and all assessments, charges, claims and liability which may be imposed upon Enright by the taxation authorities of the United Kingdom and/or of the United
States of America in respect of any liability arising from Enright’s service as a director of any affiliate of Altimmune located in the United Kingdom, and any resulting imputed income, inclusive of interest or penalties associated therewith.
Any such indemnification payment shall, to the extent necessary to offset any taxes imposed thereon, be fully grossed-up so that the net effect upon Enright is tax neutral. 

24. Counterparts. This Agreement may be executed simultaneously in two or more counterparts, each of which shall be deemed an
original, but all of which shall together constitute one in the same Agreement. 
 IN WITNESS WHEREOF, the parties hereto have
executed this Agreement as of the date first written above. 
  

									
	ALTIMMUNE INC.:	 		 	WILLIAM J. ENRIGHT:
				
	By:	 	 /s/ David J. Drutz
	 		 	 /s/ William J. Enright

		 	Chairman of the Board	 		 	
			
	Date: December 8, 2015	 		 	Date: December 7, 2015


  
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