EPA Registration Number 

66330-324 

Vol. 1 

/ 
( 

• 

• 

August 15, 2005 

Ms. Joanne Miller, PM 23 

Registration Division - 7505C 

Office of Pesticide Programs 

U.S. Environmental Protection Agency 

Crystal Mall 2, Room 266A 

1801 South Bell Street 

Arlington, V A 22202 

Subject: Agency Letter Dated June 13, 2000 

Dear Ms. Miller: 

Please find enclosed the aflidavit for the previolls year as required by the Agency letter 

dated June 13,2000. Should you have any questions in regards to this submission, please 

do not hesitate to call me at 901-432-51 18. 

Sincerely, 

'~ 

bWllGc-0~ 

Bill Washburn 

Regulatory Affairs Manager 

~-)O Be/ 772099 • 
, 

• 

• 

Affidavit 

Pursuant to the letter agreement with EPA of June 13, 2000, Micro Flo Company LLC 

("Micro Flo") hereby affirms 

(1) The source of the active ingredient in each Micro Flo technical product is the 

approved source listed on the Confidential Statement of Formula (CSF); 

(2) This affidavit applies to the following products: 

Acephate Technical 

Bifenth(tn Technical 

Ethephon 65 MUP 

iprodione Technical 

Mepiquat Chloride Technical 

Permethrin Technical 

Thidiazuron Technical 

Thiophanate-Methyl Technical 

(3) Micro Flo has not imported technical grade pesticide products other than those 

specified in Micro Flo CSFs for products intended for sale and distribution in the 

United States, and 

(4) All Micro Flo end~use products offered for sale in the United States were 

formulated from technical grade pesticide products specified in the applicable 

CSFs. 

(5) I understand that it is a violation of 18 U.S.C. Section 1001 to knowingly and 

willfully make any materially false statement or representation to EPA. I further 

understand that Micro Flo may be subject to enforcement actions based on the 

statements in this affidavit. 

Micro Flo Company LLC 

By ?id40o Ji;rrb 

William C. Wisdom 

Managing Director 

2 
• 

&EPA 

-, :) i • . ''"' ," , 

;'" ,,., 

United SteIn 

Environmental Protection Agency Wo~hingtlln, OC 20460 

" >-, 

" 

, 

• for " -

" " 

" 

I~ 

I;; 

OMON, 

Registration 

Amendment 

Other 

" 

opp Idontifier Numbet 

Numbor 

LLC/51036-402 

4: .Company/Product lNamlll 

2. EPA ProdUCI Manager 

J, Mm., 

PM' 

23 

3. Pfllpoaed Classification 

~ None 0 Ro.tlicted 

Micro Flo Company LLClThidiazuron Technical ,,'-,--,- ,"-. 

5. Namll Imd Addrll$s III Applicllnt {Include ZIP Codfl/ 

Micro Flo Company LLC 

P.O. Box 772099 

6. Expedited Reveiw. In accotdance wilh FIFRA Sectitm 3{c)f3t 

(b)(il. my ptoduct is simil3t or idenlical in composititm and labeling 

to: 

,,~ennessee 38117-2099 

U ChtICk if this is B new addrll$$ 

EPA Reg. No. _____ ~~~~~ __ ,_,~ ___ ._. __ ~_ 

.i.CJ Amllndmont - Explain billow. 

, - II 

U 

[] 

: Name 

Final printed lobels in rep.onsll to 

Agllncy lettor deted 

~ RlIsubmiuion in rO$ponn to Agllncv IlIttllf doted ~ ___ 2/6/03 "Me Too· Applicotion. 

o Nlltiliclltion· E"pillin billow. o Othllr - Explein below. 

Explanation: Uall IIddit;lInel plIgels) il nllclllsary_ IFor slIctllln t lind Svctilln 11.1 

Resubmission of nolmcalion in response 10 EPA leller 2/6/03. -~~-~ 

Per PR Notice 98-10 Seclion VI. __ Nolificalion oJ Allernale Brand Name N-phenyl·N··1.2.3·lhiadiazol-5-ylurea TGAI ~ __ ,, ___ --'---u- ___ ~ __ 

-m------------------~ 

Ill". , 

Child-RII"istant Packaging DYM 

o Nil 

,"" 

Weter Soluble Peck"ging 

- VII" 

--;; N, 

\ 

2. Type 01 Cont';n.r 

must II "VOl" 

Pa<:koge wgt 

No. PIIt 

contoin.r GJ ~::~' Gless 

Pep .. r 

...... Other rsl"';IVI ___ ~n~'b~' .. '~dru""'m'-_1 

j 

14. ~,,'.) ""., ,,' Lob., , ; 

50K9 

6. Mennv. in Which LabBI is Affixed to Prllduct U OtlNlr 

, -IV 

,b •. 

N~. 

Pam BlUce 

Tid .. 

Fedetal Regislrations Specialist 

Telophontl No. IInciude Area Codel 

9011432-5000 

Certification 

I certify thllt th., statllmonts I haYII made lin this form and all otta<:hments thareto ere ttue. eccuroto ond completo. 

I acknowilldgll that any knowfinglly fofu or mi51eeding at.tamont may be pUni,h4ble by fine or impri"'rvnenl or 

both Undlll IIPPlicablo lew. 

4. Typed Nllmll 

Pam Bruce 

EPA F«m 85'0·' '''''.3·94' I editilln. ere 

3. Till' • •• 

• • 

Federal Regi5lrationG Specialist •••••• 

• • 

•• 

2/14/03 

••••• 

• • ••••• 

WhIU - EPA Fito Copy (original) 

•• • 

: .I.$t'amped) 

• 

•• • 

•• • 

• •• 

• • • ••••• 

• 

• 

•••• • • 

oVdow· AfI1>Ic*rt Copy 

• •• •• •• 3 
• 

• 

il3/06/03 THU 09-: 22 FAl 901 432 5040 MICRO FLO 

MICAOlAFLO 

'lilIll'!mrHmrn~'<IJl'Bom:ooN C OMPAN Y 

DATE: March 5, 2003 

RE: Thidiazuron Technical, EPA Reg. #51036"402 

Notification of Altemate Brand Name 

141002 

CERTIFICATION STATEMENT 

NOTIFICATION 

MAR 0 Ii 2003 

NotificatiQn of addition of Dest per PR Notice 98cl0 

This nOtification Is consistent with the proviSions of PR'Notice 98-10 and EPA 

regulations at '10 CFR 152.46, and no other changes have been made to the labeling or 

the confidential statement of formula of this product. I understand that it is a violation 

of 18 U.S.C. Sec. 1001 to willfully make any false statement to EPA. J further 

understand that if this notification is not consistent with the terms of PR Notice 98-10 

and '10 CFR 152.46, this product may be in violation of FlFRA and I may be subject to 

enforcement action and penalties under sections 12 and 14 of FlFRA. 

'k?mlfu~ Pam Bruce 

Federal Registrations Specialist 

4 
• 

• 

For Cotton Defoliant Formulation Use Only 

N-PHENYL-N'-1,2,3-THIADIAZOL-S-YLUREA TGAI 

ACTIVE INGREDIENT: 

Thidia zuron*. . . . 

INERT INGREDIENTS:. 

TOTAL: 

*N-phenyl-N'-l,2,3-thiadiazol-S-ylurea 

. 98.30% 

1. 70% 

.100.00% 

KEEP OUT OF REACH OF CHILDREN 

CAUTION NOTIFICATION 

FIRST AID 

IF INHALED: 

• Move person to fresh air. 

• If person is not breathing, call 911 or 

give artificial respiration, preferably 

possible. 

MAli 0 ti 2003 

an ambulance, then 

mouth-to-mouth, if 

• Call a poison control center or doctor for further treatment 

advice. 

IF ON SKIN OR CLOTHING: 

• Take off contaminated clothing. 

• Rinse skin immediately with plenty of water for 15-20 minutes. 

• Call a poison control center or doctor for treatment advice. 

IF IN EYES: 

• Hold eye open and rinse slowly and gently with water for 15-20 

minutes. 

• Remove contact lenses, if present, after the first 5 minutes, 

then continue rinsing eye. 

• Call a poison control center or doctor for treatment advice. 

IF SWALLOWE 0 : 

• Call a poison control center or doctor immediately for 

treatment advice. 

• 

• 

• 

Have person sip a glass of water if able to swallow. 

Do not induce vomiting unless told to do so by the 

control center or doctor. 

Do not give anything by mouth to an unconscious person. 

poison 

• ••• 

• • •••• 

., •• • . EPA Reg. No. 51036-402 

AD Oll003 

EPA Est. No. XXXX-XXX~XXX 

NET CONTENTS: 

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• 

., •• • . • •• 

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• 

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•••• • • •••• 

•• • : ! 

•• •• 5 

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Manufactured By: 

MICRO FLO COMNPANY LLC 

P.O. BOX 772099 

MEMPHIS, TN 38117 

PRECAUTIONARY STATEMENTS 

HAZARDS TO HIJMANS AND DOMESTIC ANIMALS 

CAUTION. Harmful if swallowed, inhaled, or absorbed through the 

skin. Avoid breathing dust. Avoid contact with skin, eyes, and 

clothing. Do not contaminate food or feedstuffs. 

EMERGENCY TELEPHONE NUMBERS: 

(800) 424-9300 (CHEMTREC, transportation and spills) 

(800) 900-4000 (Poison Control Center, human health) 

(800) 345-4735 (ASPCA, animal health) 

DIRECTIONS FOR USE 

It is a violation of Federal law to use this product in a manner 

inconsistent with its labeling. 

Labeling for products formulated from this product must conform 

to that which is currently registered with the u.s. Environmental 

Protection Agency. 

Only for formulation into a defoliant, for the following uses: 

1. Terrestrial F'ood Crop: Cotton . 

2. Uses for which U.S. EPA has accepted the required data and/or 

citations of data that the formulator has submitted in support 

of registration. 

3. Uses 

U • S • 

for 

EPA 

experimental 

requirements. 

purposes that a ro 

ENVIRONMENTAL HAZARDS 

in compliance with 

Do not discharge effluent containing this product into lakes, 

streams, ponds, estuaries, oceans, or publ.ic waters unless this 

product is speci f icall y ident i f ied and addressed in an.. ·~~.oES 

permit _ Do not discharge effluent containing this prodJ:c't" to 

sewer systems without prevj_ously notifying the sewage tr;a.~~ent 

plant authority_ For guidance, contact your State ~~~~r Boa~d or 

Regional Office of the EPA. : .: ••• 

•• • 

STORAGE AND DISPOSAl, 

•••••• • •• 

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• ..... .. •••• 

• • •••• 

• • 

• •• •• •• 

, 

6 
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• 

o 

Do not contaminate water, food, or feed by storage or disposal. 

STORAGE: store 

other pesticides, 

product in original 

fertilizer, food or 

container 

feed. 

only, away from 

PESTICIDE DISPOSAL: Do not contaminate water, food or feed by 

storage or disposal. Wastes resulting from the use of this 

product may be disposed of on site or at an approved waste 

disposal facility. 

CONTAINER DISPOSAL: Completely empty liner by shaking and tapping 

sides and bottom to loosen clinging particles. Empty residue 

into manufacturing equipment. Then dispose of liner in a 

sanitary landfill or by incineration if allowed by state and 

local authorities. If drum is contaminated and cannot be reused, 

dispose of in the same manner. 

DO NOT REUSE EMPTY CONTAINER 

NOTICE OF WARRANTY 

Micro Flo Company will not be responsible for losses or damages 

resulting from the use of this product in any manner not 

specifically recommended by Micro Flo Company. User assumes all 

risks associated with such non-recommended use. 

Micro Flo Company warrants that this product conforms to the 

chemical description on the label thereof and is reasonably fit 

for purposes stated on such label only when used in accordance 

with directions under norma} use conditions. It is impossible to 

eliminate all risks inherently associated with use of this 

product. 

MICRO FLO COMPANY MAKES NO WARRANTIES OF MERCHANTABILITY OR 

FITNESS FOR A PARTICULAR PURPOSE NOR ANY OTHER EXPRESS OR IMPLIED 

WARRANTY EXCEPT AS STATED ABOVE. 

•••••• 

000 

o 0 

..... ~ 

o 0 

.. ••••• o 0 

••••• 

• ••• o 0 

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o 0 

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o 0 0 

•••• 

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7 
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113(06/03 THF 09,: 22 F.U 901 432 5040 .1HCRO FLO 

FAX TRANSMISSION 

Micro Flo Company 

Regulatory Department 

P.O. Box 772099, Memphis, TN 38117 

(901) 432-5000 

(901) 432-5031 EClX 

TO: JOl'ce Edwards # of Pages,_2_ 

(Induding Cover Page) 

COMPANY: US EPA 

FAX#: ']b3-!f)5-{eQ?-Q 

,--, 

FROM: /1lrnmw DATE: ,3-k03 

COMMENTS: 

]fg a in Coo\lQ,r711ti.on) G1-./f1 thd i'S JAe. 

8 
~-------

.~,. ,4 ,- , .. , OM. N,. 

oEPA United Stat.e f-- Registration oPP ldentifior Number 

Environmental Protection Agency f-- Amendment 

We.hington, DC 20460 293559 

L..- Other 

ilor , - I 

1. CompanvlProduct Number 2. EPA Product Manager 3, Propo.ed Clnllifre.tion 

IName) PM' DNol'lO 

7 

D Restricted 

: 5. Name and Addr ... of ApplieDnt (11If::lude ZIP Cod., 6. Expedited Review. In FIFRA Section 3(c)j3) 

(bHiI. my product is similar or in composition and labeling 

to: 

EPA Reg. No. / 

n Chtwk if t;hj$ is • now adwtl$$ Product Name / 

I - II / 

~ Amendment· Explain belew, 0 Final printed r .. ·porae to 

Ra.ubmi .. ion in re.pon •• to Agency lener datod 0 .. ,..,. Too" 

/. 0 Notifie.tion· Explain below. 0 bofow. ! 

Explanation: u •• additional peg.ts) It n.c .... ry. (For lIection I end Section II.) 

~ 

, - III 

,-,;;;- / 

Child-R •• istant Packaging u~Pacl«lgin" / I ~.r Soluble Pack8Qing 2. Typo of Container 

• a::·- _ V •• I--- VOl 

No No ~~' Pl._tic . 

Glasa 

a Certification must If .. V .... ~ Ilf -Y,,- No. par p ... , 

Unit Packoging wgt'l / w'" cantlinor Other be submitttHf 

I r3. . o ConUliner / 

r 4:~SiiOi,' Ro<, ~_~~,. i I D lobo! f--I 0" 

","""" 0" 

6. Menner in Which Lobel ;. Affixed to ptet o Other 

f-- i 

/ , -IV 

1. Contact Point (Compltlfe below (Of , " o b. fO PfOC8S$ this , 

N~. / Titlll Telephone No. (lncluda Aroo Code) 

Certification 6. Ooto App1ic~'IIion 

I certify that tho .tlll8monts I hIve mlldo on this lorm end 011 onachmont~ thGreto or. tnro, occuroto and complete. Rllcoived 

I ecknowledgo tIuIt ony knowingly falso or misloading statamant may be puniGhablo by fino or imprisonment or 

both Undor applicabla low. 

(Stamped) 

2. Sigl\Bture 3. TIllo 

14. Typed Non,. 5. Data 

9 

EPA F~m 8570·' 'R._, .... , seditions arll , WhIu - EPA FUa Copy lorIglnall Y_Now - AppU~t Copy 
------------~~~---

PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

PAPERWORK REDUCTION ACT NQTICE: Public reporting burdon for thi, coUection of information is ostimated to IlYi1rogo 0.B5 hour per 

rot>pon!lo, ineluding time for reviewing iru:uuctWQ$, £IUIrching existing dete $oure(l$, oethoring and muintuioing the dotl! needed, and clIfTlploting and 

reviewing the collection of information. S,nd COl'lT\1etlts rogarding tho burden estimole or anv oth.r aspect of thi$: collection of informtltion, including 

suggutiom, for reducing this burden, \0 Chief, Information Policy Bronch, {2136), U.S. Environmental Protoction Agency. 401 M Street, SW, 

Woshington, DC 20460. 

1!!:lJilll!i1l;rm!!!~, Thill form ill to be u"od for aU oppliclltions for now rogistretion, ond uso reregistration, amendment. r.$ubrnl$lIion, to applications 

for notificotiont, I printod labeling, reregistration, etc. In order to procass on application for a now ragistration aubmittad on thill form, tho 

following materiel mutt aecompany tho eppliclltion: 

1. Cartificotion with Ra~oct to Citation of Data (EPA Form a57().29). IIf Mt exomptod by 40 CFR 152.81 fbI {411; 

2. Confldontial Sttltoment of Formulll (EPA Form 857().4); 

3. Formuletor'a Exomption Statamant (EPA Form 8570-27); 

4. FiVil copiat of drllft laboling; 

5. Trnllo oaple. of any data 8ubmitted; 

6. Authorillltion lattor whara applicable; 

7. Matrica. whero appliCllble. 

I ""t'mii •• I~ of Labeling" Labeling should first ba oubmined in tho form of draft I,bllls wilh 1111 applications for new ragi§trelion. Such draft Illbflls m",b'l 

of typed labal taxt on 8.5 x 11 inch papor for aubmiuion or a mockup of tha propoaed Icbet If prepar,d for mockup, It should ba I ",,,,",<od in a wav as to faciliteta stor'ga in 8n 8.5 x 11 inch fila. Mockup lab,ls significentiy smaUer than 8.5 x 11 inches ehould be m"",,,,,d 'o~ 

paper for eubmiesion. I,,"',ml •• ionof Data" Data submittad in support of thie 8pplication mu§t be submitted in eccordenca with PR Notico 86·5. 

1~!!'J~a!];U!:lJgRIil;:r];!.!ll$.; .. Plaeso rosd tho instructions listod below before completing thi~ application. First datermine the typo of ragi~tretion in Block A. for which you ara submitting this application. For applicetions submitted in connactlon with Now Rogistration IIction" Sectiol'\$ 

IV must ba completad by tm. applicent. For epplications submitted in connoction with emended raugi§tration aClion,. rosubmisuions, 

;:::'o::';~~~';' reragistratione. otc .• Sactions I. II, and IV mu~t be comploted by the applicant. 

Chock the IIPproprieta ection for which you era submitting thi' form. 

1~il1QJ[!l~U ~ This lIection must be complatod, all applicabla. for all registration ections. 

1. CompanvlProduct Numbar • Insort your Compeny Numbor, if ono has been a$Signad by EPA. This number mey have baon eSllignad to you o~ e 

ballic ragictrant, a distributor, or all an astablishmant. If your product is registerod, insart tha Product Number. 

2. EPA Product Manegar - If known. fill in the nnma and PM number of tho EPA Product Manager. 

3. Propoeed Clusificatlon • Specify tM proposed Clllssification of this product. 

4. Product Nel'M - Enter the complete product Mme of this pesticide as it will appasr on the lablll. The nlUTlO muut be upeoific to this product ool.,.. 

Duplication of n&fl'lO$ i. not permitted 1!IfT!0ng products of the $Ome compony. Do not include anv brond narne or company line ds"illn.ationr;. 

5. Nema and Addre •• of Applleont· Tho MmII of tha firm Dr ponon end addross. shown in your epp~cation i& the per&on or firm to whom tho 

registration will ba illllued. If you oro acting in baholf of onothar party, you must IIUbmit authorillltion from that party to act for thom in 

mattar •• An applicant not residing in the Unitod States must hovo on IIIUtlwriled agent residing in the United Statec to oct for thom in 1111 

regilllretiQn mattars, TM name 111M complate mcillng eddru!I of such en egont mu$t accomplllnv this IIpplicotion. 

Expedited Review· FIFRA $ection 3 (c) 3 (S) provide .. for IIxpeditad raview of application; for rogilltrlltion. or emondmsnts to existing ragistrlltions. 

thaI Me lIimilllr or identicoll0 othar pesticide product$ that aro currontlv regi$tared with the EPA. In ordar for YOlJr application to be aligibht for 

expOOltad r"viow, you must provido us with tha EPA Registration Numbor and prodUct nome of tho prodUct you believe is similer to or idonticnllO 

your product. Th .. product mu"t bo ~miJar or identical in bOlh formuhnion and labolad usa ... 

~::~~~,' This lI"ction must be oornplotad for 011 applicotions submined to l!IfT!and the r"'gilltration ooly of a currentlv r ... giutored product 

for a rll$ubmiscUon In rellponse to lin Ag"ncV lanllr, for notifications to the Agencv, for lhe lIubmill.uon of final printod labeling. for 

11M for anv other eetion thet pl!lrtains to a snecifio EPA'regjstllrl'ld prodl/ct. This 8IIction Is.!!.!2! 12!2! ueed for a now eppliclltion for 

ragistretion. 

1. SubJ-ct of submiulon - Cheek the applicable block and provide th. AgoncV lotter date if appropriate. Provide a briof oxplanalion of thll purposelsl 

for the submission, such" ~thl!l (lljdition of 8 ~ile, pest or crop {$pecifyJ~; ~amend the Confidential Statoment of Formula bV ... ~; ~reregi$tration 

IilUbmi.uion~; ~oanllrallobol r.vision of usa directionll. ~ Attach a &aparote pnga If (lljditional &paco is neadod. 

~~~~~~ lPackaging and Container Information)" Thill Saction mUllt be compJet&d for allopplications submitted In connoction with new 

or appIiaable amendments. 

Type of Packeglng- Chocl:: the approprinto block if your product wlH be pe.ckegad in the indicoted pe.ekaging typo~. 

Indicat$ the aile of the individual packtlts and numbar per rota~ container. 

Type of Retail Container ·lndical0 type of containar in which product w~1 be me.tt.tad. 

Location of Not ContenU -Indicate the location of the not contents information for your prodUct. 

SileJ.) of Retail Container - SpacifV th$ net contents of .U retoil containalt for your prodUct. 

Location of U .. Dintetione. - Indicote the locetion of the Ulla directiolUl for your prodUct. 

Man/'Ief In which Iabe) '- off!XCId 10 pwduct • Indicated tho method prodUct labol ito ettechad to retail container. 

~~~~t!;~ fContact Point} - Thill Saction mullt bo completad for 011 IIPPlice.lionll for Registration actioni'. ;'0., now productll r .. gislretian, 

~mo-too, ~ reragiltretion. etc. 

1-5. Solf·axplaMtory. 

•• EPA Un Only. 

10 
I -~ ---== --------

• 

PI.IIUI""; '-~"on ,.-;.,.. bMotfI co form. FormA ro:v~. OMS No. 2070-0080 , , United Stete, a Registration oPP Identifier Number 

&EPA Environmental Protection Agency Amendment 

Washington. DC 20480 293559 Other 

Application for Pesticide - Section I 

1. Compeny/Product Number 2. EPA Product Mllnager 3. Propeeed Cle .. Wrcetion 

4. Compeny/Product IName) PM, DNone D Rllltricted 

5. Name and Add" .. of ApplIcant (Includ. ZIP CDde) 6. Expedited Review. In accordance with FIFRA Section 3(cJ(3} 

(bHi), my product is similar or identical in composition and labeling 

to: 

EPA Reg. No. 

D Ch.ck if this is a n.w lIddru$ Product Name 

Section - II 

~ Amendment· Explain below. D Final printed lebol' in re.pona.e to 

Agency letter d.,ted 

Ruubml .. ion In roepon,. to Agency letter deted D ·MII Too· ~pplic.tion. 

D Notificeoon· Explain below. D Other· Explain below. 

Explanation: u • ., eddJtionlll pegel') 11 nece .. ery. IFor lIection I and Saction II.) 

, , 

, 

Section - III 

1. Metorial Thit Product WIlla. P.ekepd In: 

Child-Re,i$tent Paekeging Unit Packaging Weter Soluble Packeging 2. TVJ)e of Contlli".r 

• B::'- Bv" , B V .. No No §M" Gla 

Pla.tic 

.. 

. e Certification must If ·V .. - No/por If-V .. • No. per Paper 

Unit Packeoing wgt. contain" Peckogo wgt contain" Othar ISpecify) be submitted , , , 

3. Location of Not Conlonte Information 4. Sizels) Rotei! Conteiner 5. locatiOn 01 label Directiens 

D o Container 

B On label 

LobO On labaling accompanying prodUct 

6. Manner in Which label i. Affixed to Product 

~ UtMgraph o Other , Pap.r ~Iuad Stenci ed 

, Section - IV 

1. Contect Point (Complere rftlf1l.S 'dirBcrly b./ow for idtmrificstron of fndividual to be contlilc/.d, if nllClIsssry, fo proCII$$ thrfillf!p!icarion.) 

N~, TItle ToJophone No. Unclude Arae Codo) 

Certification 6. Oete Appiicotion 

I certify that the s;t8temenlS I havo mllde on this form and all enachmenl$ thllreto ere truo. accurete end COmpletll. Recaived 

I ecknowledge thet any knowil'lgly fals. or misJeeding lIlatemant mey be punishable by fino or imcrilOonmont or (Stamped) 

both und.r applicable lew. 

2. Signature 3. TItle 

4. Typed Name 5. Data 

11 

EPA Form 8570-1 meV. " s-.S4) PreVloU, edition, era obsolete. Whlu. • EPA FIle Copy lorlglnall Vellow - Applle&nt Copy 
PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

PAPERWQRK REDUCTION ACT NQTICE: Public reponing burden for this co!i/)ction of information is cSlimat&d to average 0.85 hour per 

rs~pon,;o, including time for roviewing iootructiol<S, ~srching IIxisting dotn sources, gllthurlng end mllintuining tho data neoded, llna comploting lind 

reviewing the collsction of ;nforma-Jon. Send comments regarding tho burden '!ltim~te or any other .spect 01 this collection of inloITnelion, inc1ua'og 

l>uggll$\ions for ,,,dueinQ this burden. to Chiof, Information Pelicy Bronch, 12136), U.S. Environmental PrOIOClion Agllncy, 401 M Strllot, SW, 

Washington, DC 20460. 

INSTRUCTIONS: Thie form is to bo used for an IlppliCelions for OIIW registrOllon, end use reregistration, amondment, rllSubminion, 10 oppliclltions 

for nOlifications, final printed labeling. rereQ',;;trDlion, elC. In ordor to process en I'Ipplication for 10 new registration 6ubmitted on this form. the 

following !1"I3Ullial mullt Mcomparw Ihe application: 

1. CortifiolOtion with Respect to Citetion of Dllta (EPA Form 6570-29). {II not eXempted by 40 CFR 152.$t Ib) (4)); 

2. Confidential SUltllmont of Formule IEPA Form 8570-41; 

3. Fotrr'llJlotor's Exemption Stetemll'nt IEPA Form 8570-27); 

4. Five copios of droft Illboling; 

5. Throe capilli of any date $ubrniuod; 

6. Authorization lotter where &pplicobl&; 

7. MatriCOI where applieablo_ 

Submiull><l of I..beHno _ labeling should first be aubmiu&d in the form of droit labeb with all epplicotiom: for now registrOlion. Such draft 11lb~ls may bo 

In thl!; form of typed lablll t"let on 8.5 x 11 inch pllp&< for eubmin;on or a mockup of the propooed label. II prepered for mock.up, it should be • 

con§tl1.Jcted in a way as to facilitate storoge in on 8,5 x 11 inch file. Mockup labels significantly emallor than a.s x " inchos shouk! be mounted 0 

x 11 inch peper for subminion. 

Submlulon of Datil' 0&\11 subm1nsd in &UPport of lhis application must be submittod in accordance with pR Notice 86-5. 

SPECIFIC INSTRUCTIQNS: Plell~e re&d the in&tructions listed bolow boforo completinn this IIppliclltion. Fir&t dotermino tho type of rsgl$.,,,tion 

tlction. lililtod in Block A, lor which you tiro lilubmitting thi6 eppllcation. For ~plicatio!J6 :;ubmiued in connection with New Regi§lration actionlil, Sectionlil 

I, HI, ar.d IV must be compleutd by the epplicant. For applicalions submitted in connection with amended rerbgi$tratilln action$, r!)$ubmi$$ion$, 

notification~. reregi$trl.ltionS. ote., Sections I, II, end IV must be completed by thc applicant. 

Block A· Chock the appropriote action for which you are submitting this lorm. 

SECTIQ!Y.l- This section must be complllled, e§ IIppliceblll. lor ell registration ectioOll;. 

1. ComplOtlylProdul't Numb.,r - In$el1 YOUI Company Number. il OM has boen ossigned by EPA. This number mayheve bO(ln ,,,,,signed to you as e 

be$ic rogi:;tranl, a distributor, or liS an cliltsbllshmenl. II your product is regiOlorod, insert the Producl Number. 

2. EPA Produl't Manllger· If known, fill in tha nome and PM nUmbllr of tho EPA Product Monegsr. 

3. Propgsed CI ... "llicatlon - Spocify tha proposed cls$sificotion of this prC>duct. 

4. Produl't Name· Enter thll complete product nMTl1! 01 this pesticide ea it win appear on tho label. The narne muDI ba specific to thig product only. 

Duplication of nameG is not permitted among product& 01 tha some company. Do not include eny brsnd nome or compllny limil deliligmiltioOl •. 

5. Name and Addra .. of Applicant - The nDmO of the lirm or pefflon and eddrcs1l shown in your application is thll pereon or firm to whom the 

registretion will bo iuued. If you are acting in behall of enother party, you must submit outhorization from thllt party to aot for them in reglstretion 

msnen:. An applicent not ruiding in tho Unitod States mugt hllvlI sn outho~z&d agant residing in the United Stetes to ect for thom in ell • 

rogistration mattllrs, The nl.llTle and completo mailing address 01 such tin egent rruJlII eccompany this nppliclltion, 

6. Expedited Relllew - FIFRA aection 3 {c) 3 (S) provides for expedited review of applications fOI registrelion, or amendments to e)Cisting registretions, 

thet ere ,imilar or identical to other pe;tlcide product' that IIro currontly registarad with tn. EPA. In order for your applicotion to b(l eligible for 

exp&dited raview, you muat provide U$ with the EPA Rllgistration Numbar and product nO!1"l3 of the product you boliova is ,imilar to or identical to 

your product. Thr.t prodUct must be cirrular or Identical in both formulation end laboled usell. 

SECTION II· Thi, lIection fT\UfI be oompleted for all opplicetionc eubmitled to errand tho regietrotion only of a currently regietered product 

IAmendment), for a rcpubmisslon In l'1IepoO$O to on Agency loner. for notificationl to Ihe Anency, for thellubmiulon of fine! printed lebeling, for 

roregistretion end for eny othr.tr action that porteins to a specific EPA-rogiiter&Sl product. This section ie!l2! 12.1u! uoed for a new application for 

rogistratlon. 

1. Subfect o(submi .. lon • Check the applicable block lind provide the Agoncy lettsr dete if appropriete. Provide a briof explenetion of tho purposels) 

lor the wbminion, such 0$ *tn. addition of e site, post or crop (specify)-; *arnand the ConfidanticJ Statement of Formula by .. ."; -roregistrlllion 

wbmi.$ion"; -g.norallebel rovi,ion of Ulle directions.- Anach a 'opllrato psg. if additionmspace is n$edod. 

SECTIQN III (Peckllging end Container Information! - This SlIction mutt be comp)oted for ell epplicillions submitted in connection with nllW 

regic-trat!on or oppIiGeble emondmontJ;, 

,. Type of P.ekllging - Chr.tck thr.t appropriato block jf your product w~1 bs peckegod in the indicated peckllging typell. 

Indic.te the si~o of thO il'ldividuel packatll and number per retail container. 

2. Type of A.t.n Contelner - Indieeto type of contuinor in which product will be merkoted. 

3. lec.tlon of N.t Contente - Indicate the locetion of the nat conlOnt. Information fer your product. 

4. Siu{.! of Retait ContaiMl' - Spoclfy tho not contantll of all retail container. foi YClUr prodUct. 

S. loution of Us. Dinetiorw· Indicate the location 01 thll un directions for your product. 

G, M.nner in which label. affixed to product -Indicated the meth2d product Illbelis ettached to rll1ail eontainor. 

seCTION IV IContoct Poinl) • Thill Section must be completed for ell eppliclltions lor RegiGtration ection~. 1.0., new prCtducts regilltretion, 

relHJbmisJion, -mtt-too," rarogi.tration, etc. 

1-5. Sell·explanatory. 

6. EPA Ua. Only, 

12 
I 

• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 2D46D 

OFFICE OF 

PREVENTION. PESTICIDES AND 

TOXIC $UBS1N,CES 

Ms. Pam Bntcc 

Federal Registration Specialist 

Micro Flo Company LLC 

P.O. Box 772099 

Memphis, Tennessee 38117-2099 

February 6. 2003 

RE: Notification of Additional Brand Name: Thidizuron Technical 

EPA Reg. No.: 51036-402 

Submission Dated: February 6, 2003 

Dear Ms. BOice: 

The notification referred to above is incomplete and cannot be accepted at this time. 

A notification labeling change must include a copy of the label with the changc(s) clearly 

marked. Please refer to the PR Notice 98-10 Section VI and resubmit yom notification. 

Any questions that YOli may have concerning this action, please contact me at 

703/305-5479. 

Sincerc£, 

N ti cations Review Coordinator 

R g" tration Division (7505C) 

13' 
5L . F, 0 .... No , M •. 

. § Registration opp Identifier Number 

&EPA United Stal •• 

Environmental Protection Agency Amendment 

W81hington, DC 20460 

v Other 

for , - , I 

I. Company1f>roouct Numb.r 2. EPA Produet Monagor 3, Propos&<:! Classifieation 

Micro Flo Co I I r. J. MHle< ~N.'" D R .. tricltK! 

4~icm Flo 

INam .. , PM, 

LLC/Thidiazuron Technical 23 

Nomo .~ Addross of Applicont (lnclud. ZIP Coda) 6. Expedited Reveiw. In accordance with FIFRA Section 31c)j3) 

Micro Flo Company LLC Ibllil. my ptoduct is similar Of identical in composition and labeling 

P.O. Box 772099 to: 

Memphis, Tennessee 38117-2099 EPA Reg. No. 

D Chock if thi1l ;$ II now (lddrfl$S Product Name 

, - II 

D Amondment· Expl&in bfllow. 2J Final printed lablllls in 'fIj'l.onso 10 

D D AgoneV rotto, dOIM --- Rosubminion in r"Rpons" 10 Agoncv lotto, doted. -Me Too· Application. 

Notification· EXplain below. D Olhof' Explain below, 

Us.additionol pag .. CsI if n .. cessary. IFof .ection I end Section 11.1 

Nolmealion lor Allernale 6rand Name: N·phenyl·N', C ,2,3·thiadiazol·5·ylurea TGAI 

-III 

1. M.~ri" no;. "' .... 0< "" .. , ~, 

i Unil Packaging Wet". Soluble Pack"ging 2. Typ" of Conlainef 

~V" ,- V" -

v N. ~ N. ~ 

V .. 

~ ... 

PI .. " .. tic N. Glan 

* c.tification must u~; .. , 

No. p.f ',~;::,; w,l ~~:.rf Pllpef 

wgl. conl";nO' conl";n.f ..... OIMr i liberdrum 

M $ubmittfld 

I e.' N" , ! 4. Si,.,., ,,, .. , IS~ ,., ...... 11 

... b., U 50 Kg 

6. Mannlf in Which Lobol i. Aflixed 10 Pfoduci 1-' ~i U 0,",., 

, -IV 

11 . Coo,." P.i., • ifom •. .. • b., "hi .. 

IN~' Tltlo .n'.~Alal Cod.) 

Pam Bruce Fedetal Regisetations Specialist 

Certification 

I certilv thallhe $lot_nI5 I hivi madl on this fo"" aod aU Ittaclvnenl. Ihefolo afa trul, .ccurala Ind cWI&: 

I acknowledge thet any kf\(lw~nglly 1$1$0 Of misleading 5111etmenl m&y ba punishablo by fino or imprilonmet!1 Of • • IS,""""'I bOlh urKI.r I lew. • ••••• .. •• 

•••• 2. i J, TItle • • r1LvY! T~{ II (X 

••••• •••• 

Federal RogiSlralions Specialist • • 

./ ••••• 

• ••• 

4. Typed Nema S.Oal* • • .' .. Pam Bruce 1/28/03 • • • .. • .. • 

"'. 'Mm .. 7.·1 , .... "34" , O(Iitiont .fa obsoloto. 'MWUo ' EPA FlIrt Copy lorioInal) V_·. , ",<, 

14 
• 

• 

J["c;:" d l',o,., '"Y, ;-r"},,",,~ 

h"'l"''-'''''>'_''' :l:'.'l""" O:,Q',c; 

-'Oll F""""\"""",, ;"-'.' .• j .w. 

;';',,'b, ",;[."", 1,.(" ~G·lf.J 

NOTICE OF PESTICIDE: 

~ Registration 

___ Reregistration 

Micro Flo Co. LLC 

P.O Box 772099 

Memphis, TN 381 17 

fFi\ ''''{j. ~;",_ t;" ,- : 

51036-402 

Conditional 

THIDIAZURON TECHNICAL 

Noto: t:h~"g'-'~ "" ""'01,,,,) :lltf"",,g Lll .,,)b~t"';"'" ()-"", lh'''' "",,,c'I",,:-(] '" "O'''10''''-~O'' WlLh Ulis r·"lJSl,-"U.O'-, r""~,·. 

11". "dA'iL~'~d lo und "cC'-,pt;"d by >-I", r\",q;"t,-~t"x, Db;~,on rrio,. to '.!::;" of til!' l"bGi in """"e,CC!. 1" ,"",y 

'_"",-("sp"~d'Ol""_c', "" U>b [H",h.,: _,l"'~y~ ,",H-"'- t" i.Il'· .,hov", tPT< rC9"'U",;t;o1 Jlu,obc", 

lJ._ l,.,~", {,r ,"f,."",,,""" (""_,;i,,,d joy lh'"' ".,,,":.,,,,,,(, (l,,, "V,v,_, "',".~d I'nAi'_-~<k' '" l,.",,_"_'y 

"_<IC3t"I'RCi,-'_ ·_"1~3\",-.'d '.:"i'" '_j", r-",,·,·,-,,) ,,,-.. -;r:,,,,d,_-, ,'u,ql~"k _,,,J 1':"l1~'''\I-;,d,," "":. 

III "td"," lo F'U".,:l ],'o_,H" ,,,,,I "'" ,_-,,,),,,,,,,,,, ,j,,_- Ad,,, "";''-'''''''''-. '," b', """ )Un, ""y ,)" ''''Y ,-"",_, """I"""'; '" 

'_'!''''::~'c ,jp,: :"~9j"t'-,ll"1l 0:' \,'o':)('lo,· f" _.,xnClhll,_'" "',~h til" '\c~, j'h" ~:cc,_,p:"n..;-""~ ""Y ,,,",.,_, ", 'CGl",.,.,c~'''n 

KII, 'h" r,""j~":,",-,,, ,,(,' i',,,,,,,n ,,,,~.-,, th' ,;-( J:_ ",,: te, C"_' ce,,~l'-~"d ,,', <;l-('"", ,b" ,-.-,,-,)~L)-dr;,_ d r,,,llI 'J' 

This prodlTct is conditiol1nlly registcred ill nccordallcc with FIFRA sec. 3(c)(7)(A) provided 

that you: 

S11bmit and/or citc all dnID rcquired for registrntion/rcregistrillion ofy01Jr product whcn 

thc Agency recplires nil registrants of similar products to submit slleh dati1. 

2. Make the following: labcl changc: 

a. Revise the EPA Registration Number to read, "EPA Reg. No. 51036-402" . 

b. Within the third (3) paragraph under the head'lI1g entitled "NOTICE OF WARRANTY," 

revise "PURPUSE" to rend as "PURPOSE" 

3, Submit, within six (6) months of the date of this rcgistrationl1oticc, thc solubility ofthc 

Thidiazuron technical in organic solvcnts. Alternatively, )'011I11ay ~m1\'idejustification for a waiver 

of this data rCC]1lircmcnt 

4. Submit, witiTin six (6) months ortllc date of this registration notice, the completed storage 

~t<lbjlitylcormsion characteristics df-'J![I of tile Thidiazuron technical in organic solveJJ!s. Altcn)(;ltively, 

you may prO\'ide justification for 11 waiver of this data rcquircmcnt. 

5 Submit two (2) copies ofthc revised final printed l;lhel for the rlOcord 

"", 

JAN 0 2003 

15 

I 

I 
-- ---- ------- - --- - ---- ----------- -, 

page 2 

EPA Reg. No. 51036-402 

If these conditions are not complied with, the registration will be subject to cancellation in accordance with 

FIFRA sec. 6(e). Your release for shipment of tile product constitutes acceptance of these conditions. 

A stamped copy of the label is enclosed for your records. 

Joanne 1. Miller 

Prochlct Manager (23) 

Herbicide Branch 

Registration Division (7505C) 

• Enclosures 

• 

16 
• 

• 

------------------, 

For Cotton Defoliant Formulation Use Only 

THIDIAZURON TECHNICAL 

ACTIVE INGREDIENT: 

Thidiazuron*. 

INERT INGREDIENTS:. 

*N-phenyl-N'-1,2,3-thiadiazol-S-ylurea 

. 98.30% 

1.70% 

.100.00% 

KEEP OUT OF REACH OF CHILDREN 

CAUTION 

FIRST AID 

IF INHALED: 

• Move person to fresh air. 

• If person is not breathing I 

give artificial respiration, 

possible. 

call 911 or 

preferably 

an ambulance I then 

mouth-to-mouth, if 

• Call a poison control center 

advice. 

or doctor for further tre~:~~'1Emt 

00 0 

IF ON SKIN OR CLOTHING: o 0 0 

o 00 

• Take off contaminated clothing. ••••••• 

o 0 0 

• Rinse skin immediately with plenty of water for 15-20 mi~t~s. 

• Call a poison control center or doctor for treatment: advi·ce·. 

IF IN EYES: •• • :-: 

•• ••• ••• 

• Hold eye open and rinse slowly and gently with w~~~ for lS-20 

minutes. • ••• o 0 

• Remove contact lenses, if present, after the first 5 mi1"l.~es, 

then continue rinsing eye. : •••• 

, 00 

• Call a poison control center or doctor for treatment adv~ce . 

IF SWALLOWED: 

• Call a poison control center or doctor immediately for 

treatment advice. 

• Have person sip a glass of water if able to swallow. 

• Do not induce vomiting unless told to do so by the poison 

control center or doctor. 

• Do not give anything by mouth to an unconscious person. 

EPA Reg. No. 51036-

NET CONTENTS: 

EPA Est. No. XXXX-XXX-XXX 

Manufactured By: 

MICRO FLO COMNPANY LLC 

P.O. BOX 772099 

MEMPHIS, TN 38117 

ACC/i:PTED 

wilh COm.tENTS 

in F.PA Lo:tt .. r Dated 

17 
• 

• 

PRECAUTIONARY STATEMENTS 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CAUTION. Harmful if swallowed, inhaled, or absorbed through the 

skin. Avoid breathing dust. Avoid contact with skin, eyes, and 

clothing. Do not contaminate food or feedstuffs. 

EMERGENCY TELEPHONE NUMBERS: 

(800) 424-9300 (CHEMTREC, transportation and spills) 

(800) 900-4000 (Poison Control Center, human health) 

(aDO) 345-4735 (ASPCA, animal health) 

DIRECTIONS FOR USE 

It is a violation of Federal law to use this product in a manner 

inconsistent with its labeling . 

Labeling for products formulated from this product must conform 

to that which is currently registered with the U.S. Environmental 

Protection Agency. 

Only for formulation into a defoliant, for the following uses. 

1. Terrestrial Food Crop: Cotton. 

2. Uses for which U. S. EPA has accepted 

citations of data that the formulator 

of registration. 

3. Uses for experimental purposes that 

U.S. EPA requirements. 

the 

has 

are 

ENVIRONMENTAL HAZARDS 

• • •••• 

.. . ., . · .. requir¢&:~ta add/or 

submitted ~n ~~H~Qrt •••••• • F.. 

in 

• .. • . ... • •• 

••••• ••• cqJIlp.,J..iance .wi th 

• ••• 

• • •••• 

... 

. , . · .. Do not discharge eff luent containing this product into lakes, 

streams, ponds, estuaries, oceans, or public waters unless this 

product is specifically identified and addressed in an NPDES 

permit. Do not discharge effluent containing this product to 

sewer systems without previously notifying the sewage treatment 

plant authority. For guidance, contact your State Water Board or 

Regional Office of the EPA. 

STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by storage or disposal. 

STORAGE: Store product in original container only, away from 

other pesticides, fertilizer, food or feed. 

2 

18 
• 

• 

PESTICIDE DISPOSAL: Do not contaminate water, food or feed by 

storage or disposal. Wastes resulting from the use of this 

pJ.-oduct may be disposed of on site or at an approved waste 

disposal facility. 

CONTAINER DISPOSAL: Completely empty liner by shaking and tapping 

sides and bottom to loosen clinging particles. Empty residue 

into manufacturing equipment. Then dispose of liner in a 

sanitary landfill or by incineration if allowed by state and 

local authorities. If drum is contaminated and cannot be reused, 

dispose of in the same manner. 

DO NOT REUSE EMPTY CONTAINER 

NOTICE OF WARRANTY 

Micro Flo Company will not be responsible for losses or damages 

resulting from the use of this product in any manner not 

specifically recommended by Micro Flo Company. User assumes all 

risks associated with such non-recommended use. 

Micro Flo Company warrants that this product conforms to the 

chemical description on the label thereof and is reasonab*~.fit 

for purposes stated on such label only when used in accO~.;.i~hce 

with directions under normal use conditions. It is impossibl~ to 

eliminate all risks inherently associated with use ot ·.khis 

product. •••••• • 

• •• • • ••• 

• MICRO FLO COMPANY MAKES NO WARRANTIES OF MERC~~~BILI~· OR 

FITNESS FOR A PARTICULAR PURPUSE NOR ANY OTHER EXPRES~'OR I~~~ED 

WARRANTY EXCEPT AS STATED ABOVE. ..:... ••• 

• •••• • 

•••• 

• •••• 

. , . . , . • • • 

) 

19 
• 

• 

~~r Cotton Defoliant Formulation Use Only ~ ... 

THIDIAZURON TECHNICAL 

~/ACTIVE INGREDIENT: 

Thidiazuron* . 

INERT INGREDIENTS:. 

/ TOTAL: 

/' *N-phenyl ~N ' -1,2, 3 - thiadiazol- 5-ylurea 

. 98.30% 

1. 70%~'---" 

.100.00% 

~ KEEP OUT OF REACH OF CHILDREN 

- CAUTION 

FIRST AID 

/-r F INHALED: / 

/. Move person to fresh air. 

Y If person is not breathing, 

give artificial respiration, 

call 911 or 

preferably 

possible. 

an ambul ance I then 

mouth-to-mouth, if 

/' Call a poison control center or doctor for further tr~~thent 

advice. 

/IF ON SKIN OR CLOTHING: 

..... 

•• • ... 

•• • 

/,/ Take off contaminated clothing. ••••••• 

/- Rinse skin immediately with plenty of water for ls-·2b mirnl<t.-es. 

~' ,Call a poison control center or doctor for treatm~e.: ad~te~~ ______ IT IN EYES: •• •• :.: . ..... ... J. Hold eye open and rinse slowly and gently Wl.th w.2i1;,~F for ~5-20 

minutes. . ... '. Remove contact lenses, if present, after the first 5 mifi'Ates, 

then continue rinsing eye. : •••• 

-.' Call a poison control center or doctor for treatment ad~ic~ . IF SWALLOWED: 

,. Call a poison control center or doctor immediately for 

treatment advice . 

• Have person sip a glass of water if able to swallow. 

___ • Do not induce vomiting unless told to do so by the poison 

control center or doctor . 

• Do not give anything by mouth to an unconscious person. 

EPA Reg. No. 51036-

~ET CONTENTS: 

~EPA Est. No. XXXX-XXX-XXX 

~~ Manufactured By: 

MICRO FLO COMNPANY LLC 

P.O. BOX 772099 

MEMPHIS, TN 38117 

20 
• 

• 

PRECAUTIONARY STATEMENTS 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

/ 

/CAUTION. Harmful if swallowed, inhaled, or absorbed through the 

skin. Avoid breathing dust. Avoid contact with skin, eyes, and 

clothing. Do not contaminate food or feedstuffs. 

EMERGENCY TELEPHONE NUMBERS: 

(800) 424-9300 (CHEMTREC, transportation and spills) 

(800) 900-4000 (Poison Control Center, human health) 

(800) 345-4735 (ASPCA, animal health) 

" DIRECTIONS FOR USE 

~It is a violation of Federal law to use this product in a manner 

inconsistent with its labeling. / 

/ Labeling for products formulated from this product must conform 

to that which is currently registered with the U.S. Environmental 

Protection Agency. 

~ly for formulation into a defoliant, 

ft. Terrestrial Food Crop: Cotton ,< 

for the following uS~A. 

/ /'3. 

Uses for which U.S. EPA has accepted 

citations of data that the formulator 

of registration. 

Uses 

u.s. 

for 

EPA 

experimental 

requirements. 

purposes that 

the 

has 

are 

/ENVIRONMENTAL HAZARDS 

• • ••• • ., . . , . · ., requir®6.data and/or 

submitted;n f>l~Drt 

in 

• ••••• • ••• 

• • •• • ••• 

• •• 

cdmb-:tiance·· with 

•••••• • 

• ••• 

• • •••• 

., . •• • 

• •• ~o not discharge effluent containing this product into lakes, 

streams, ponds, estuaries, oceans, or public waters unless this 

product is specifically identified and addressed in an NPDES 

permit. Do not discharge effluent containing this product to 

sewer systems without previously notifying the sewage treatment 

plant authority. For guidance, contact your State Water Board or 

Regional Office of the EPA. 

/'·STORAGE AND DISPOSAL 

..... ·-/60 not contaminate water, food, or feed by storage or disposal. 

?TORAGE: Store product in original 

other pesticides, fertilizer, food or 

container 

feed. 

only, away from 

2 

21 
• 

• 

" /'PESTICIDE DISPOSAL: Do not contaminate water, food or feed by 

, storage or disposal. Wastes resulting from the use of this 

product may be disposed of on site or at an approved waste 

disposal facility . 

...----co'i'nAINER DISPOSAL: Completely empty liner by shaking and tapping 

sides and bottom to loosen clinging particles. Empty residue 

into manufacturing equipment. Then dispose of liner in a 

sanitary landfill or by incineration if allowed by state and 

local authorities. If drum is contaminated and cannot be reused, 

dispose of in the same manner. 

~DO NOT REUSE EMPTY CONTAINER 

------"NOTICE OF WARRANTY 

~Micro Flo Company will not be responsible for losses or damages 

resulting from the use of this product in any manner not 

specifically recommended by Micro Flo Company. User assumes all 

risks associated with such non-recommended use. 

/Micro Flo Company warrants that this product conforms to the ~ chemical description on the label thereof and is reasonably fit 

for purposes stated on such label only when used in accIMraance 

with directions under normal use conditions. It is impossible to 

eliminate all risks inherently associated with use or·.~his 

product. •••••• • 

• •• • • •••• y/ MICRO FLO COMPANY MAKES NO ,_ WARRANTIES OF MERCH1W~ILlm'i.· OR 

FITNESS FOR A PARTICULAR l?URPUSK' NOR ANY OTHER EXPRESS-·OR I~~:!\.ED • •• WA..R.RJ>..NTY EXCEPT AS STATED ABOVE ~--'( •• :... ••• 

••••• • 

•••• 

• • •••• 

.. . . , . · .. 

l 

22 
l¥J .. 'M' ,- "f"!:' ,MR •• • '·"·95 

United Steles Registration opp Identifier Number 

oEPA Environmental Protection Agency I- Amendment 

Wuhington. DC 20460 

~ Other 

, for I • , , I 

f. Company/Product Number 2. EPA Product Manager 3. Proposed Cteuificetien 

51036·UNE J. Miller E]Nene o Restricted 

4.,:. Company/Product {Name) PM' 

Thidiazuron Technical 23 

5. Nl'lmtI and Address of Applicant (IncJud. ZIP Cod., 6. Expedited Reveiw. In accordance with FIFRA Section 3{cH3) 

Micro Flo Company LLC (bWt, my product is similat ot identical in composition and labeling 

P.O. box 772099 to: 

Memphis, TN 38117 EPA Reg. No. 

o Ch.ck if thl$ a. new eddrll$$ D, Name 

, - II 

~ A~""m,"'· ,,,,., b.,ow. U Final printed Illbol. in rep,onso to 

Agency hmor dllted 

Resubmiuion in fesponse to Agency tetter dated 0 ~MII Too" Application. 

D NotifiC:lltion - Explain bolow. 21 Othar • Explain below. 

Explanation; Usa additionol pegehll if neC:lIssary. IFor sac:tion r lind Sec:tion II.t 

Revised Oata Matnx 

, - III 

1. ,P"d.,"'" .. Child·Ruilltant Packaging , , Water Solublll Pac:koaing 2. Typll 01 Conteinor 

~Y" ,. V" - Yu [;J M". 

~ No '7 Ple,tic: '-: " No No GleSll 

must J~,i'" ~~.:per If "YlI"" No. per Paper , wgt. c:ontainer Pac:kege wot c:ontainer V Other nber drum 

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;So loc:etion of Net Contontl , 4 .• ,,,,., .,," 

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l=:J ,,' ~ L,b,' U 50 Kg On label 

6. Manner in Whic:h Lebel is Affixed to Produc:t :-v· I~~~~~:. o Other 

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'. c,"," Po'" of inrJividulli to b. ' • to proC:"$$ this 

N~m •. G . Title No""~udo Area Code) 

Manager of Regisltatlons 901-432-50otJ •••• • OrriS asklns 

Certification 6.:t'dt:1 ""'plic:.tilln 

I c:anify that the statamont9 I havo mada on this form end en ettoc:hment. thereto ara truo, oc:eurlltll and e..-.,.t."", Rec:tiVad 

I acknewlodge that eny knowlinglly fal'e er misleading 5tlltllmont may b. punishable by fino or implisenrnellt 0' : •• .stamped) 

both und~r law. ... • • 

•••• 

2. Signotura /1", 3, Title .. • .. -6~ • • • 

Manager of Regislrations • •••• •••• • • ••••• • 

{ •••• 14. Typed Namll 5. Ollta • • 

•••• 

Morris Gaskins Jan. 8,2003 • • 

• • • •••• 

,8.70-1 "".3·94' • editions ere , Whi1 •• EPA Fa. COfIy loriginall Y.'ow~eo,y 
• 

....... --~-.--------------

MICRO~ FLO 1,"~ .. "fb.L~'\TI1'1mml; COMPANY 

FAX 

(4 pages) 

1-703-308-1825 

January 8, 2003 

Mr. Marcel Howard (Team 23) 

Registration Division 

Office of Pesticide Programs (7504C) 

Crystal Mall 2, Room 258 

1921 Jefferson Davis Highway 

Arlington, VA 22202 

RE: Thidiazuron Technical 

EPA File Symbol Sl036-UNE 

Dear Mr. Howard, 

The attached submission is a revised Data Matrix (internal and 

public record) for the above referenced application in response to 

our telephone discussion today. 

Please call if you have any questions. 

Regards, 

Morris Gaskins 

Manager of Registrations 

901-432-5119 

morris.gaskins@microflocompany.com 

•••••• 

• •• • • 

•••••• 

• .. • 

•• ••• 

• • 

•••• • • •••• 

• • • ••••• 

• 

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• •••• • 

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• • •••• 

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•••• 

24 
• • Form Approved OMS No. 2070-0060 I 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

401 M Street, S.W. 

WASHINGTON, DC 20460 

Paperwork Reduction kJ: Notice: The public reporting burden for this collection of information is estimated to average 0.25 hours per response for registration activities and 0.25 hours per 

response for reregistration and special review actiWies, including time for reading the instructions and completing the necessary forms. Send comments regarding the burden estimate or 

any other aspect of this collection of information, including suggestions for reducing the burden to: Director, OPPE Information t-1anagement Division (2137) U.S. Environmental Protection 

Agency,~91 M Street, S.W., Washington, DC 20460. Do not send the form to this address. 

OATAMATRIX 

Date: January 8, 2003 EPA Reg No.,F;>. Symbol 51036-UNE Page 1 of 1 

Appllcant's/Registrant's Name &. Address: Micro Flo Company Product: 

P.O. Box 772099 Memphis, TN 38117 THIDIA2URON TECHNICAL 

Ingredient: Thidiazuron 05 # 51707-55-2 

Guideline Reference Number l Guideline Study Name ( MRID Number ( Submitter ! status ! Note 

830 Group A I Proouct Identity, Comp:>sition and Analysis I Micro Flo Co. llC I Submitted with appl. 

I 830 Group B Physical/Chemical Properties I Micro Flo Co. lLC -I-=.ubmitted ~ith appl. 

GENERIC DATA 

CITE ALL 

cmAll 

CITE All 

CITE All 

CITE All 

cmAll 

~ 

•• • 

"--t-.····-"------:?~I·.. -1---1 

• • • • 

• - •• :0. 

I •• _. • -I· • -- I .~-!-~ ::~'~.~:~:~--::~::_:'~_r~----~~--7CC=~~C7~----L-------_rn:~----- Signature ~ d /...J .. ".' ...•.. :.... Nam.andTotle, Morris Gaskins Date 

~ ~ ~ Manager of Registrations 1/8/03 

EPA Form 8570-35 (9-97) ElectronIC and aper versionS available. Submit only Paper Vision_ Agency Internal Use Copy 
---- • • Form Approved OMB No. 2070-0060 

UNITED STATES ENVIRONMENTAL PROTEcnON AGENCY 

401 M Street, S. W. 

WASHINGTON, DC 20460 

Paperwork Reduction k.t. Notice: The public reporting burden for this collection of information is estimated to average 0.25 hours per response for r€9istration activities and 0.25 hours per 

response for reregistration and special review acti'vities, including time for rea:ling the instructions and completing the necessary forms. Send comments r€9arding the burden estimate or 

any other aspect of this collection of information, iocluding suggestions for reducing the burden to: Director, OPPE Information Management Division (2137) U.s. Environmental Protection 

Agency, 401 M Street, S.W., Washington, OC 20460. Do not send the form to this address. 

DATA MATRIX 

Date: January 8, 2003 EPA Reg No./File Symbol 51036-UNE Page 1 of 1 

Applicant's/Reglsttant's Name &. Address: Micro Flo Company Product: 

P.O. Box 772099 Memphis, TN 38117 THIOIAZURON TECHNICAL 

Ingredient: Thidiazuron CAS # 51707-55-2 

Guideline Reference Number \ Guideline Study Name l MRID Number Submitter Status \ Note 

Micro Flo Co. LLC Submitted with appl. 

Micro Flo Co. LLC Submitted with appl. 

Uniroyal Chemical Co. PAY 

Nor~Am Chemical Co. PAY 

Spray Drift Task Force PAY 

Agricultural Re~Entry Task Force PAY 

Aventis CropScience USA PAY 

Ourdcor Residential Exposure Task PAY 

Force 

• • • ••• • • • • ••• •• • • ••• •• • • • • • • • •••• 

• • .. • ... • 

• • • • • • • • •• • • • •• • • • • • . ---.~-----. . . . . . • • Signature /1cn-t ).f: • • • ••• •••• Name and Title: Morris Gaskins Date • • • • • 

N Manager of Registrations 1/8/03 '" "',.,,, "'"-" 0".," .,,, In n." r:ln~ __ : ___ ..I []_~_" "_~:_,.,..J.,,,.,.;! ... hl_ c, ,h~:~ " ... 1" 0,."". Iii ... ",., I\"",n,"" 0, ,hli,.. 0"",,""" r ...... " 
,-------------------------------------

• 

• 

CHEMICAL CHEMICAL NAME 

120301 Thidiazuron (ANSI) 

COMPANY# 000264 AVENTIS CROPSCIENCE USA LP 

, DATA TYPES' 2 TW. ALEXANDER DRIVE BOX 12014 

EU AT EC FW EF OT RESEARCH TRIANGLE PARK NC 

XX 27709 

COMPANY# 000400 CROMPTON MANUFACTURING COMPANY, INC. 

, DATA TYPES '74 AMITY RD 

EU AT EC FW EF OT BETHANY CT 

XX XX 06524 

COMPANY# 051036 MICRO-FLO COMPANY LLC 

, DATA TYPES 'BOX 772099 

EU AT EC FW EF OT MEMPHIS TN 

XX XX38117 

COMPANY# 066607 SPRAY DRIFT TASK FORCE 

MCKENNA & CUNEO LLP 

* DATA TYPES'" 1900 K STREET, NW 

ELi AT EC FW EF OT \V ASHINGTON DC 

XX 20006 

COMPANY# 071754 BEVERIDGE & DIAMOND, Pc. 

AGENT FOR OUTDOOR RESIDENTIAL EXPOSURE 

, DATA TYPES * 1350 I STREET, N.W. 

EU AT EC FW EF OT WASHINGTON DC 

XX 20005 

COMPANY# 071755 BEVERIDGE & DIAMOND, Pc. 

AGENT FOR AGRICULTURAL RE-ENTRY TASK FO 

, DATA TYPES' 1350 I STREET, N.\V. 

EU AT EC FIV EF OT IV ASHINGTON DC 

XX 20005 

27 
• 

• 

Date: August 19.2002 

SUBJECT 

FROM: 

TO: 

Product Chemistry Review of Thidiazuron Technical 

Shyam B. Mathur, Ph.D 

Product Chemistry Team 

Technical Review Branch/RD (7505C) 

Joanne Miller / Marcel Howard, PM 23 

Herbicide Branch I RD (7505C) 

DP BARCODE: 0283364 

EPA REG. NO.: 51036-UNE 

REGISTRANT: Micro-Flo Company, llC 

USE: Herbicide 

INTRODUCTION 

The registrant has submitted product chemistry data to support the registration of technical Thidiazuron 

herbicide produced in the facility located at The product chemistry data have been 

submitted under MRID Nos. 456019-01 thru 456019-04. 

SUMMARY OF FINDINGS: 

1. The registrant has submitted the Confidential Statement of formula for basic formulation (dated 01-16-02) 

for Thidiazuron technical. The nominal concentration (98.3%) of the AI agrees with the product label claim. 

The product chemistry data submitted corresponding to guideline reference 830.1550 (Product identity & 

Composition), and 830.1750 (Certified limits) satisfy the data requirements of 40CFR§158.155 and 158.175 

respectively. 

2. The product chemistry data submitted corresponding to guideline reference 830.1600 (Description of 

material used to produce the product) satisfy the data requirements of 40CFR§ 158.160. The registrant has 

provided the product specifications data on all the starting materials used for the production of this herbicide. 

3. The product chemistry data submitted corresponding to guideline reference 830.1620 (Description of 

production process) satisfy the data requirements for 40CFR§158.162 . 

4. The product chemistry data submitted corresponding to guideline reference 830.1670 (Discussion on the 

formation of impurities)satisfy the data requirements for 40CFR§158.167. 

5. The data were submitted corresponding the guideline reference 830.1700 (Preliminary analysis) satisfy 

the data requirements of 40CFR§158.170. The Thidiazuron content was determined by HPlC method, with 

UV detector operating at 290 nm . The separation was performed on a Supelco LC-8 DB, 25 cm x 4.6 mm. 

5 um column. The method was validated for accuracy, linearity, and precision. 

6. The data submitted corresponding the guideline reference 830.1800 (Enforcement Analytical method) 

satisfy the data requirements of 40CFR§158.180. The HPlC method(UV, 290 nm) was used for the AI and 

the impurities. The method was validated for accuracy, linearity, and precision. 

1. The product chemistry data submitted corresponding to guideline reference 830 Series Subgroup B 

(Physical/Chemical properties)for the technical produced at satisfy the data requirements of 

40CFR 158.190. 

28 

*Product ingredient source information may be entitled to confidential treatment* 
• 

• 

---------------------

BARCOOE:D283364; Reg. No .. 51036*UNE PRODUCT: Thidiazuron Technical 

CONCLUSIONS: 

The TRS has reviewed the product chemistry data submitted for Thidiazuron Technical, produced at the

facility by Micro-Flo, Co., and has concluded that: 

1. All the product chemistry data submitted corresponding to 830 Series Subgroup A and Subgroup 8 satisfy 

the data requirements of 40CFR§158.155 to 158.190 and are acceptable, except for the solubility of the AI 

in the organic solvents. 

2. The registrant has provided the solubility of the Thidiazuron technical in water, but did not provide 

information of its solubility in organic salvenls. The applicant must provide this information. 

3. The CSF for basic formulation(dated 01-16-02) is filled out correctly and completely. The nominal 

concentration oflhe AI concurs with the product label claim nominal concentration. It is in compliance with PR 

Notice 91-2. The CSF for basic formulation is acceptable . 

29 

*Product ingredient source information may be entitled to confidential treatment*
w 

o 

• 

BARCODE:D283364; Reg. No.: 51036-UNE PRODUCT: Thidiazuron Technical 

830.1550. ProduC1ldentity: (MRID No. 456019-02) 

Common Name: Thidiazuron Technical 

Chemical Name. IUPAC: 1-phenyl-3-(1,2,3-thiadiazoJ-5-yl)urea 

CAS; N-phenyl-N'-1.2,3-thiadiazol-5-yl urea 

CAS No.: 51707-55-2 

PC Code No.: 120301 

Empirical formula: Cg Ha N.l OS 

Molecular Weight: 220.25 

Structural formula: 

Q 0 !IN 

I )l ~-,\~ aNN S 

H H 

• 
• 

• 

ATIACHMENT II 

REVIEWOF PRODUCT CHEMISTRY, OPPTS 830 SERIES 

Chemical Name (IUPAC. ANSI, etc.) IUPAC: 1-phenyl-3-(1.2.3·thiadiazol-5-yl)urea 

CAS: N-phenyl-N'-1 ,2,3-thiadiazol-S·yl urea 

Chemical Number (CAS; PC Code) CAS No. 51707-55-2 

PC Code:104801 

Registration/Symbol No. S1036-UNE 

Type of Product (T, MP, EP) 98.3% TGAII MP 

DP Barcode 0283364 

Reviewer --'S"'hLya"'m-"-'S",.::M"'a"th"u"r _________ , _____ _ 

Branch Chief -=D"e"b"-or"a"'h-'M"c"C"'a"II'---________ -'-_____ _ 

Table l' Manufacturing and Impurity Data for the Thldiazuron Technical 

GLN Requirement MRIO Status' Details and/or Oeficiency' 

830.1550 Product Identity and 456019-02 Y The product label claim is 98 3% concurs with 

composlt'lon (CSF) the nominal concentration of the AI In the CSF 

(dated 01.16·02), Certified limits are within 

standard certified tlmlts 

830 t600 Descnption of materlats used 4560t9-02 Y The product specification sheets(MSDS} for alt 

to produce product the startln materiats have been provided 

830 t620 Description of production 4560t9·02 Y The registrant has provided detailed 

process information about the synthesis of the 

technical The amounts of each starting 

material and conditions under which the 

reaction were performed are provided. 

830. t670 Discussion of forma\lon of 4560t9-02 Y The registrant has provided reqUIred 

impurities information on the rormation of Impurities Tho 

mechanism s for the formation of impurities 

dunng different stages of the prodUCtion 

orocess have been submitted 

830 t700 Pre~minary analysis 456019-03 Y Registrant has provided 5 batch analysis for 

TGAI produced at the facility. The HPLC 

method was used. The analytical method was 

validated for linearit ,accuracy and precision 

830 t750 Certified limits 4560t9-02 Y The certified limits for the TGAI were Within the 

(CSFr standard certified limits The limits were verified 

b 5 batch anal sis 

830.1800 Enforcement analytical 4560t9-03 Y HPLC method was used to quantitate the AI 

method UV detector at 290 nm The method validated 

for accuracy, lineanty, & precISIOn 

t A" Acceptable: N '" Unacceptable (see Deficiency), NfA " Not Apptlcable 

, Refer to CSI Appendix A for details. 

31 *Product ingredient source information may be entitled to confidential treatment*
Table 2 Physical and Chemical Properties f the Thidiazuron Technical 'See Note for acceptance condition 

GLN Requirement MRID Status' Result' or Deficiency 

830.6302 Color 456019·04 Y Light greenish-yellow 

830.6303 Physical state " " y Powdery solid 

830.6304 Odor " " y No detectable odor 

830.6313 Stability to normal and " " y The TS was found to be stable at RT and al SOC. 

elevated temperatures. Did flot show any changes when brought In contact 

metals, and metal ions With eu & Zn and corresponding sulfates The 

HPLC method was used to determine the 

concentration of the AI 

8306314 OXldationlredvctiQn NA 

chemical incompatibility 

• 

8306315 Flammability NA 

830.631 Explodability NA 

6 

8306317 Storage stability 456019·04 I One year study IS in proQress 

830,6319 MiSCibility NA 

830.6320 Corrosion characterisll I I Siudy is progress along wilh one year slorage 

stabllt 

8307000 ,H 456019-04 Y 564 

8307050 UVNislble absorption 456019-04 Y See Note t 

830,7100 Viscosity NA 

8307200 Melting pOint! 4560t9-04 y 209 9C to 210 4C 

Melting range 

• 

8307220 BOiling point! NA 

Boihno. ranae 

830.7300 Densityl 4560t9-04 Y 045 glce or 28 Ibslcu fI 

relative densityl 

bulk denSity 

830,7370 DIssociation constants 4560t9-04 Y pKa '" 8,86 

in water 

830.7550 Partition coefficient 456019-04 Y Kolw"'59 @ pH:::73 

(n-octanot/water), 

shake flask method 

8307840 Water solubility 4560t9-04 U 31,0 ppm at 2SC 

column elullon method, Data are not provided for solubility In organic 

shake fiask method solvents 

8307950 Vapor pressure 456019-04 Y 4 x to(-9) Pa at 25C 

, A'" Acceptable; N '" Unacceptable (see Deficiency); NIA '" Not applicable 

~ For example, "brown" lor 830 6302. "t5S" C" for 830.7200, 

A' '" The data are acceptable onl if the registrant will provUje information on the methods used to determine these properties, 

32 

~----~~--~~~~~~~~~~~~~~~---' 
w 

w 

Note 1 830 7050. UVNisible 

Iili I. max 

Neutral 286.4 nm 

228.4 nm 

Acidic 287.6 nm 

223.4 nm 

BasIc 329.0 nm 

257,4 nm 

• • 

Molar coefficient (tog e) 

9.75 

9.37 

8.89 

8.82 

10.18 

9.60 
Pages 34-39 *Manufacturing process information may be entitled to confidential treatment*
• 

• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF 

PREVENTION, PESTICIOES 

ANO 

27/AUG/2002 

MEMORANDUM 

Subject: Name of Pesticide Product: 

EPA Reg. No./File Symbol: 

Thidiazuron Technical 

51036-UNE 

From: 

To: 

DP Barcode: 0283425 

Case No: 071504 

PC Code: 120301 

Eugenia McAndrew, Biologist E tV, 

Technical Review Branch ) , V'v 

Registration Division (7505C) ~ \. 

Marcel Howard, PM Team 23 

Herbicide Branch 

Registration Division (7505C) 

Applicant: Micro Flo Company 

P.O. Box 772099 

Memphis, TN 38117 

FORMULATION FROM LABEL: 

Active Ingredient(s}: 

120301 Thidiazuron 

Inert Ingredient(s): 

Total: 

TOXIC SUBSTANCES 

% by wt. 

98.30 

100.00% 

ACTION REQUESTED: PM requests review of acute toxicity data for Thidiazuron Technical 

EPA File Symbol, 51036-UNE. 

40 
• 

• 

BACKGROUND: Micro Flo Company has submitted a six pack of acute toxicity studies in support 

of registration of Thidiazuron Technical, EPA File SymbolS1 036 M UNE. The studies were assigned 

MRID numbers456019 M05to -10. The studies were conducted at Still meadow, tnc., Sugar Land, 

Texas. 

RECOMMENDATIONS: The six studies have been reviewed and are classified as acceptable. 

The acute toxicity profile for Thidiazuron Technical, EPA File Symbol 51036 M UNE, is as follows: 

acute oral toxicity IV Acceptable MRID 45601905 

acute dermal toxicity IV Acceptable MRID 45601906 

acute inhalation toxicity IV Acceptable MRID 45601907 

primary eye irritation IV Acceptable MRID45601908 

primary skin irritation IV Acceptable MRID 45601909 

dermal sensitization Negative Acceptable MRID 45601910 

LABELING: Based on the toxicity profile above, the following are the precautionary and first aid 

statements for this product as obtained from the Label Review System. 

PROOUCT ID #: 051036-00402 

PRODUCT NAME: Thidiazuron Technical 

PRECAUTIONARY STATEMENTS 

Hazards to HUmans and Domestic Animals: 

SIGNAL WORD: CAIJ1l0N 

First Aid: No statements are required. Registrant may use category 1M3 statements • 

2 

41 
• 

• 

....... - .. _._-_ .. _._._------, 

DATA EVALUATION RECORD 

STUDY TYPE: ACUTE ORAL TOXICITY TESTING (870.1100 formerly §81-1) 

Product Manager: 23 Reviewer: Eugenia McAndrew 

TEST MATERIAL PURITY: Thidiazuron Technical: 98.15% aj. 

CITATION: Kuhn, J. (2001) Thidiazuron Technical; acute oral toxicity in rats. Stillmeadow, Inc., 

Sugar Land, Texas. Laboratory Report Nurnber6646-01. December 27, 2001. MRID 

45601905. Unpublished. 

SPONSOR: Micro Flo Company, c/o SciReg, Inc., 12733 Director's Loop, Woodbridge, VA 

22192 

EXECUTIVE SUMMARY: In an acute oral toxicity study, five young adult albino SpragueDawley rats/sex (Weight: 263-279 9 males; 173-190 9 females; Source: Texas Animal 

Specialties, Humble, TX) were given a single oral dose of Thidiazuron Technical (Lot. No. 

TDZ20010918: 98.15% a.l.: light yellow powder) al5050 mg/kg (limit dose). The test 

substance was mixed with acetone to produce a 30% wlv concentration, An individual dose 

was calculated for each animal based on its fasted body weight and administered by gavage at 

a volume of 16,8 mUkg . Animals were observed for clinical signs of toxicity and mortality for 14 

days post dosing. Individual bosy weights were recorded just prior to dosing and on days 7 and 

14, or at the time of death. Necropsies were performed on all animals. 

Oral LO" Males = > 5050 mg/kg (observed): Oral LO" Females = > 5050 mg/kg (observed) 

Thidiazuron Technical is classified as Toxicity Category IV based on the observed LDso values 

in both sexes, 

One male died on day 2; all other animals survived and gained weight during the study . 

Clinical signs noted included activity decrease, ataxia, diarrhea, decreased defecation, loss of 

hind limb coordination. Ocular discharge, polyuria, respiratory chirp, splayed legs, small/dark 

feces, sensitivity to touch and withdrawn testes. The survivors recovered from these symptoms 

by day 7. At necropsy, the animal that died on test revealed testes withdrawn, lungs bright red 

with dark blotches, liver dark, gas and tan slurry in stomach and hard yellow substance in small 

intestine. Three females that survived to study termination had mottled lungs. 

This study is classified as Acceptable (870.1100) and satisfies the guideline requirement for an 

acute oral study in the rat. 

COMPLIANCE: Signed and dated GLP, Quality Assurance and Data Confidentiality statements 

were provided. 

3 

42 
• 

• 

RESULTS: 

Number of Deaths/Number Tested 

Dosage (mg/kg) 

Males Females Combined 

5050 1/5 0/5 1/10 

OBSERVATIONS: One male died on day 2; all other animals survived and gained weight 

during the study. Clinical signs noted included activity decrease, ataxia, diarrhea, decreased 

defecation, loss of hind limb coordination. Ocular discharge, polyuria, respiratory chirp, splayed 

legs, small/dark feces, sensitivity to touch and withdrawn testes. The survivors recovered from 

these symptoms by day 7. 

GROSS NECROPSY: The gross necropsy on the animal that died on test revealed testes 

withdrawn, lungs bright red with dark blotches, liver dark, gas and tan slurry in stomach and 

hard yenow substance in small intestine. Three females that survived to study termination had 

mottled lungs . 

4 

43 
• 

• 

DATA EVALUATION RECORD 

STUDY TYPE: ACUTE DERMAL TOXICITY TESTING (870.1200 formerly §81-2) 

Product Manager: 23 Reviewer: Eugenia McAndrew 

TEST MATERIAL PURITY: Thldiazuron Technical; 98.15% a.L 

CITATION: Kuhn, J. (2001) Thidiazuron Technical; acute dermal toxicity in rabbits. Still meadow, 

Inc., Sugar Land, Texas. Laboratory Report Number 6647~01. December 27,2001. MRID 

45601906. Unpublished. 

SPONSOR: Micro Flo Company, clo SciReg, Inc" 12733 Director's Loop, Woodbridge, VA 

22192 

EXECUTIVE SUMMARY: In an acute dermal toxicity study, five New Zealand White albino 

rabbits/sex (Weight: 2.150-2.475 kg males; 2.000-2.475 kg females: Source: Ray Nichols 

Rabbitry, Lumberton, TX) were dermally exposed to a single application of Thidiazuron 

Technical (Lot. No. TDZ20010918; 98.15% a.i.; light yellow powder) at 5050 mg/kg (limit dose) 

for 24 hours. Each dose was moistened with 0.66 mL of vehicle (80% ethanol and 20% 

deionized water) per 1 g of test material and was evenly applied to approximately 10% of the 

total body surface area. Animals were observed for clinical signs of toxicity and mortality three 

times on the day of dosing and once daily for 14 days. Individual body weights were recorded 

just prior to dosing and on days 7 and 14. Observations for dermal irritation were made 60 

minutes after removal of wrappings and on days 4,7,11 and 14. Necropsies were performed on 

all animals. 

Dermal LD50 Males = > 5050 mg/kg (observed); Dermal LD50 Females = > 5050 mg/kg 

(observed) 

Thidiazuron Technical is classified as Toxicity Category IV based on the observed LDso values 

in both sexes. 

All animals survived and gained weight during the study. The only clinical sign observed was 

soft feces on the day of dosing. Dermal irritation was present at all dose sites on day 1 and at 

one dose site on day 4. Necropsy after 14 days revealed mottled lungs in 7/10 animals. 

This study is classified as Acceptable (870.1200) and satisfies the guideline requirement for an 

acute dermal study in the rabbit. 

COMPLIANCE: Signed and dated GLP, Quality Assurance and Data Confidentiality statements 

were provided. 

5 

44 
• 

• 

RESULTS: 

Number of Deaths/Number Tested 

Dosage (mg/kg) 

Males Females Combined 

5050 0/5 0/5 0/10 

OBSERVATIONS: All animals survived and gained weight during the study. The only clinical 

sign observed was soft feces on the day of dosing. Dermal irritation was present at all dose 

sites on day 1 and at one dose site on day 4. 

GROSS NECROPSY: Necropsy after 14 days revealed mottled lungs in 7/10 animals . 

6 

45 
• 

• 

DATA EVALUATION RECORD 

STUDY TYPE: ACUTE INHALATION TOXICITY TESTING (870.1300 formerly §81-3) 

Product Manager: 23 Reviewer: Eugenia McAndrew 

TEST MATERIAL PURITY: Thidiazuron Technical; 98.15% a.i. 

CITATION: Carter, L. (2001) Thidiazuron Technical; acute inhalation toxicity in rats. 

Still meadow, Inc., Sugar Land, Texas. Laboratory Report Number 6648·01. December 27, 

2001. MRID 45601907. Unpublished. 

SPONSOR: Micro Flo Company, clo SciReg, Inc., 12733 Directors Loop. Woodbridge, VA 

22192 

EXECUTIVE SUMMARY; In an acute inhalation toxicity study. five young adult SpragueDawley rats/sex (Weight: 256-325 9 males; 182-220 9 females; Source: Texas Animal 

Specialties, Humble, IX) were exposed by nose only inhalation to Thidiazuron Technical (Lot 

No. TDZ20010918; 98.15% a.i.; light yellow powder) at 2.40 mgfL for4 hours. The test 

substance was generated as an aerosol. All animals were observed for clinical signs of toxicity 

and mortality during the exposure and for 14 days post exposure. Individual body weights were 

recorded just prior to the inhalation exposure and on days 7 and 14. Necropsies were 

performed on all animals. 

Inhalation LCso Males = > 2.40 mg/L (observed); Inhalation LCso Females = > 2.40 mg/L 

(observed) 

Thidiazuron Technical is classified as Toxicity Category IV based on the observed LCso values 

in both sexes. 

All animals survived and gained weight during the study. Clinical signs including piloerection, 

activity decrease and red crust around the eyes were noted immediately after removal from the 

exposure chamber. All animals recovered from these symptoms by day 2. The gravimetric 

chamber concentration was 2.40 mg/L. The average mass median aerodynamic diameter was 

2.6 j.1m with a geometric standard deviation of 4.7. Necropsy after 14 days revealed no gross 

abnormalities. 

This study is classified as Acceptable (870.1300) and satisfies the guideline requirement for an 

acute inhalation study in the rat. 

COMPLIANCE: Signed and dated GLP. Quality Assurance and Data Confidentiality statements 

were provided. 

7 

46 
• 

• 

RESULTS: 

Exposure Concentration Number of Deaths/Number Tested 

mglL 

(Gravimetrically Determined) Males Females Combined 

2.40 015 015 0110 

Chamber Atmosphere 

Exposure concentration MMAD GSD 

2.40 rng/L 2.6 urn 4.7 

Chamber Environmene 

Chamber Volume 500 L 

Airflow 187 LPM 

Temperature 71°F 

Relative HumidJ.tY 60~64% 

II Nose only 

OBSERVATIONS: All animals survived and gained weight during the study. Clinical signs 

including piloerection, activity decrease, and red crust around the eyes were noted immediately 

after removal from the exposure chamber. All animals recovered from these symptoms by day 

2. 

GROSS NECROPSY: Necropsy after 14 days revealed no gross abnormalities. 

8 

47 

~. _____________________________ ---.J 
• 

• 

DATA EVALUATION RECORD 

STUDY TYPE: PRIMARY EYE IRRITATION TESTING (870.2400 formerly §81-4) 

Product Manager: 23 Reviewer: Eugenia McAndrew 

TEST MATERIAL PURITY: Thidiazuron Technical; 98.15% a.i. 

CITATION: Kuhn, J. (2001) Thidiazuron Technical; acute eye irritation in rabbits. Stillmeadow, 

Inc., Sugar Land, Texas. Laboratory Report Number6649~01. December 18, 2001. MRID 

45601908. Unpublished. 

SPONSOR: Micro Flo Company, clo SciReg, Inc., 12733 Director's Loop, Woodbridge, VA 

22192 

EXECUTIVE SUMMARY: In a primary eye irritation study, 0.1 mL by volume (0.040 g) of 

Thidiazuron Technical (Lot. No. TDZ20010918; 98.15% a.i.; light yellow powder) was placed 

into the conjunctival sac of the right eye of six New Zealand White albino rabbits (Source: Ray 

Nichols Rabbitry, Lumberton, TX). All animals were observed for ocular irritation at 1, 24, 48 

and 72 hours post-instillation. 

Thidiazuron Technical is classified as Toxicity Category IV. 

Conjunctivitis (redness) was noted in one eye at the one-hour observation. No positive effects 

were noted at 24 hours. 

This study is classified as Acceptable (870.2400) and satisfies the guideline requirement for a 

primary eye irritation study in the rabbit. 

COMPLIANCE: Signed and dated GLP, Quality Assurance and Data Confidentiality statements 

were provided . 

9 

48 
• 

• 

RESULTS: 

Number I tested 

Observations Hours 

1 24 48 72 

Unwashed eyes 

I" 0/6 0/6 0/6 0/6 

Iritis 0/6 0/6 0/6 0/6 

1(', . 

Redness" 1/6 0/6 0/6 0/6 

0/6 0/6 0/6 0/6 

~r more Icyuhcd to be 

0/6 0/6 0/6 0/6 

i 

OBSERVATIONS: Conjunctivitis (redness) was noted in one eye at the one~hour observation. 

No positive effects were noted at 24 hours . 

10 

49 

l 
• 

• 

DATA EVALUATION RECORD 

STUDY TYPE: PRIMARY DERMAL IRRITATION TESTING (870.2500 formerly §81-5) 

Product Manager: 23 Reviewer: Eugenia McAndrew 

TEST MATERIAL PURITY: Thidiazuron Technical; 98.15% a.i. 

CITATION: Kuhn, J. (2001) Thidiazuron Technical; acute dermal irritation in rabbits. 

Stillmeadow, Inc., Sugar Land, Texas. Laboratory Report Number 6650~01. December 18, 

2001. MRID 45601909. Unpublished. 

SPONSOR: Micro Flo Company, c/o SciReg, Inc., 12733 Director's Loop, Woodbridge, VA 

22192 

EXECUTIVE SUMMARY: In a primary skin irritation study, six New Zealand White albino 

rabbits (Source: Ray Nichols Rabbitry, Lumberton, TX) were dermally exposed to Thidiazuron 

Technical (Lot No. TDZ20010918; 98.15% a./.; light yellow powder) for 4 hours. On day 0, 500 

mg of test substance moistened with OAmL of 80% ethanol was applied to each test site and 

covered with a single 6 cm2 surgical gauze patch. Animals were observed 1, 24, 48 and 72 

hours after patch removal. 

Thidiazuron Technical is classified as Toxicity Category IV based on the resolution of dermal 

irritation by 72 hours. 

Primary Dermal Irritation Index (POll) :::: 0.25 One hour after patch removal, very slight 

erythema was noted at all six dose sites. By 24 hours, all sites were free of dermal irritation. 

This study is classified as Acceptable (870.2500) and satisfies the guideline requirement for an 

primary skin irritation study in the rabbit. 

COMPLIANCE: Signed and dated GLP, Quality Assurance and Data Confidentiality statements 

were provided. 

RESULTS: Primary Dermal Irritation Index (PDII) ~ 025 

OBSERVATIONS: One hour after patch removal, very slight erythema was noted at all six 

dose sites. By 24 hours, all sites were free of dermal irritation. 

11 

50 
• 

• 

DATA EVALUATION RECORD 

STUDY TYPE: DERMAL SENSITIZATION TESTING (870.2600 formerly §81-6) 

Product Manager: 23 Reviewer: Eugenia McAndrew 

TEST MATERIAL PURITY: Thidiazuron Technical; 98.15% a.i. 

CITATION: Kuhn, J. (2001) Thidiazuron Technical; skin sensitization in guinea pigs. 

Stillmeadow, Inc., Sugar Land, Texas. Laboratory Report Number 6651-01. January 24,2002. 

MRID 45601910. Unpublished. 

SPONSOR: Micro Flo Company, clo SciReg, Inc., 12733 Director's Loop, Woodbridge, VA 

22192 

EXECUTIVE SUMMARY: In a dermal sensitization study conducted with Thidiazuron Technical 

(Lot. No. TDZ20010918: 98.15% a.i.: light yellow powder), 30 young adult male and female 

Hartley albino guinea pigs (Source: Charles River Laboratories, Wilmington, MA) were tested 

using a modifICation of the Buehler method. Preliminary testing was conducted with four 

animals to determine the correct concentrations for induction and challenge. Twenty test 

animals were induced with three applications (six hours/exposure, once per week for three 

weeks) of 400 mg of test substance moistened with 0.3mL of 80% ethanol. Ten naive control 

animals were treated once weekly with 0.3 mL of 80% ethanol. On day 29, after resting for two 

weeks, 400 mg of test substance moistened with 0.3mL of acetone (highest non-irritating 

concentration) was applied to the twenty test guinea pigs and to the ten naive control guinea 

pigs for a six-hour challenge exposure. Reactions were scored 24 hours after each treatment 

and 48 hours after the first induction and challenge. A positive control study using 1-Chloro-2, 

4-0initrobenzene (ONCB) was conducted within six months of the main study to validate the 

test system. 

Thidiazuron Technical is classified as a non-sensitizer based on the results of this study . 

No dermal irritation was noted at any of the test sites during the induction phase. The study 

report states that HObservations for 10 of the 20 test animals were not recorded at 48 hours 

after the initial induction treatment." This deviation did not affect the outcome of the study. 

Following the challenge, no dermal irritation was noted at any of the test animal or naive control 

animal sites. Based on these results, the test substance is not considered to be a contact 

sensitizer. The positive response observed in the ONCB study validates the test system used in 

this study. 

This study is classified as Acceptable (870.2600) and satisfies the guideline requirement for an 

dermal sensitization study in the guinea pig. 

COMPLIANCE: Signed and dated GLP, Quality Assurance and Data Confidentiality statements 

were provided. 

12 

51 
• 

• 

PROCEDURE: In a dermal sensitization study conducted with Thidiazuron Technical (Lot. No. 

TOZ20010918; 98.15% a3.; light yellow powder), 30 young adult male and female Hartley 

albino guinea pigs (Source: Charles River Laboratories, Wilmington, MA) were tested using a 

modification of the Buehler method. Preliminary testing was conducted with four animals to 

determine the correct concentrations for induction and challenge. Twenty test animals were 

induced with three applications (six hours/exposure, once per week for three weeks) of 400 mg 

of test substance moistened with O.3mL of 80% ethanol. Ten naive control animals were treated 

once weekly with 0.3 mL of 80% ethanol. On day 29, after resting for two weeks, 400 mg of 

test substance moistened with 0.3mL of acetone (highest non-irritating concentration) was 

applied to the twenty test guinea pigs and to the ten naive control guinea pigs for a six-hour 

challenge exposure. Reactions were scored 24 hours after each treatment and 48 hours after 

the first induction and challenge. A positive control study using 1-Chloro-2, 4-0initrobenzene 

(ONCB) was conducted within six months of the main study to validate the test system. 

RESUL T5: No dermal irritation was noted at any of the test sites during the induction phase. 

The study report states that uObservations for 10 of the 20 test animals were not recorded at 48 

hours after the initial induction treatment: This deviation did not affect the outcome of the 

study. Following the challenge, no dermal irritation was noted at any of the test animal or naive 

control animal sites. Based on these results, the test substance is not considered to be a 

contact sensitizer. The positive response observed in the ONCB study validates the test system 

used in this study . 

13 

52 

-------------------------------' 
ACUTE TOX ONE-LINERS 

1. DP BARCODE: D283425 

2. PC CODE: 120301 

3. CURRENT DATE: 27/AUG/2002 

4. TEST MATERIAL: Thidiazuron Technical (Lot. No, 10Z20010918; 98.15% a.i.; light yellow 

powder) 

Study/Species/Lab Tox. Core MRID Results Cat. Grade Study # IDate 

Acute oral toxicity/rat 45601905 LDso > 5050 mg/kg (males IV A 

Stillmeadow, Inc. females combined) 

6646-01/12-27-01 

• Acute dermal toxicitylrabbit 45601906 LDso > 5050 mg/kg (males IV A 

Stillmeadow, Inc. females combined) 

6647-01/12-27-01 

Acute inhalation toxicity/rat 45601907 LC50 > 2.40 mg/L (males IV A 

Stillmeadow, Inc. females combined) 

6648-01/12-27-01 

Primary eye irritation/rabbit 45601908 Minima! irritant IV A 

Stillmeadow, Inc. 

6649-01/12-18-01 

Primary dermal irritation/rabbit 45601909 PDII = 0.25 IV A 

• Sti!!meadow, Inc. Slight irritant 

6650-01/12-18-01 

Derma! sensitization/guinea pig 45601910 Non~sensjtizer - A 

Stillmeadow, Inc. 

6651-01/1-24-02 

Core Grade Key: A =Acceptable, S = Supplementary. U = Unacceptable, V = Self Valldated 

14 

53 
• 

• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MICRO FLO CO. LLC 

P. O. BOX 772099 

MEMPHIS, TN 38117 

2/08/2002 

PRODUCT NAME: THlDIAZURON TECHNICAL 

COMPANY NAME: MICRO FLO CO. LLC 

OPP IDENTIFICATION NUMBER: 269412 

EPA FILE SYMBOL: 51036-UNE 

EPA RECEIPT DATE: 2/05/02 

SUBJECT: RECEIPT OF APPLlCA TION FOR A NEW REGISTRATION 

DEAR REGISTRANT: 

OFnCE or 

PREvENTION PESTICIDES AND 

TOXiC suaSTANCES 

The Office of Pesticides Programs has received your application for a new registration 

and it has passed an administrative screen for completeness. 

Please note that this is only a notification of receipt of your application. This is only the first step 

in the application process, and does NOT constitute approval. 

If you have any questions, please contact the Insecticide Branch at 703-305-7448. 

Sincerely, 

Front End Processing Staff 

Information Services Branch 

Infonnation Resources & Services Division 

In!eme! Address (URL)· hnp flwY.w epa gOY 

RecycllXiiRllCyclable .P,inted WIth Vegetable 011 Based Inks on RecyciDd Paper !Mlnlmum SO% P05tConsUmCi conu!""!! 54 
• 

• 

SdReg, Inc, 

Sciellce ~IH.! Regulatory Clmsull~m~ 

Ms. Joanne Miller 

Document Processing Desk (APPL) 

Office of Pesticide Programs (7504C) 

U.S. Environmental Protection Agency 

Room 266A, Crystal Mall 2 

1921 Jefferson Davis Highway 

Arlington, V A 22202-450 I 

Re: New Product Registration 

N Thidiazuron Technical 

Dear Ms. Mi lief: 

February 5, 2002 

On behalf of Micro Flo Company, Sci Reg, Inc. is submitting a registration package for 

Thidiazuroll Technical. Micro Flo is submitting its own product chemistry and acute 

toxicology. and is relying on the cite-all method of data support for all other required 

data. 

Should you have any questions. please call. 

Enclosures 

Sincerely. 

;lii~/~ C-----_ 

Frederick . Smith 

Senior Regulatory Specialist 

12733 Din:cHlr\ Lon!" \\'o()ubridgo.!. VA 22 192 

Tek'rhoIlC: 17m) 494~6S01) F:1C:-.ill1ilc: om) 492-6600 

\\'ww.Sci Ro.!g.cOJl) 55 
• 

• 

- , 

U.S. ENVIRONMENTAL PROTECTION AGENCY 

Office of Pesticide Programs 

FEB 192002 

MICRO FLO CO. 

P.O. BOX 772099 

MEMPHIS, TN 381172099 

Report of Analysis for Compliance with PR Notice 86-5 

Thank you for your transmittal of 02/05/02. Our 

has completed a preliminary analysis of the material. 

provided as follows: 

staff 

The results 

Your submittal was found to be in full compliance with 

the standards for submission of data contained in PR 

Notice 86-5. A copy of your bibliography is enclosed, 

annotated with Master Record ID/s (MRIDs) assigned to 

each document sUbmitted. Please use these numbers in 

all future references to these documents. Thank you for 

your cooperation. If you have any questions concerning 

this data submission, please raise them with the 

cognizant Product Manager, to whom the data have been 

released . 

are 

56 
. . 

• 

• 

SdReg, Inc. 

Science and Regu!atof} Consultants 

456019-00 

Ms. Joanne Miller 

Document Processing Desk (APPL) 

Office of Pesticide Programs (7504C) 

U.S. Environmental Protection Agency 

Room 266A, Crystal Mall 2 

1921 Jefferson Davis Highway 

Arlington. VA 22202-4501 

February 5, 2002 

Re: New Product Registration 

w Thidiazuron Technica1 

5/GSb-UN£ 

Dear Ms. Miller: 

On behalf of Micro Flo Company, SciReg. Inc. is submitting a registration package for 

Thidiazuron Technical. Micro Flo is submitting its own product chemistry and acute 

toxicology, and is relying on the citewall method of data support for all other required 

data. 

Should you have any questions. please call. 

Enclosures 

Sincerely. 

;1Jirr,\J>">'>' 

Frederick . Smith 

Senior Regulatory Specialist 

, " ««<~ <'~ 

12733 Direclor's Loop, Woodbridge, VA 22192 

Telephone: (03) -1.9-1.-6500 Facsimile: (03) -1.92-6600 

www.SciReg.com 

, , 

, , 

, 

" " < 

.. , , " , , 

, , , , 

" 

57 
., 

• 

• 

TRANSMITTAL DOCUMENT 

Micro Flo Company 

P.O. Box 772099 

Memphis. TN 38117 

Submitter 

SciReg, Inc.* 

12733 Director's Loop 

Woodbridge, VA 22192 

*SciReg. Inc. is the authorized agent for Micro Flo Company. 

Regulatory action in supPOrt of which this package is submitted 

New Product Registration: 

Thidiazuron Technical 

Transmittal Date 

February 5, 2002 

Contents 

Vol. 1 Administrative materials 

Vol. 2 Summary of the OPPTS 830.1000 Product Properties Test Guidelines 45601901 

Vol. 3 Group A Product Chemistry: Product Identity and Composition, Description of 45601902 

Materials Used to Produce the Product, Description of Production Process, 

Discussion of Impurities, and Certified Limits (OPPTS 830.1550, 830.1600, 

830.1620,830.1670,830.1750) 

Vol. 4 HPLC Analysis of Thidiazuron TGAI for Percent Purity and Approximate 4560 1903 I 

Percent Impurities (OPPTS 830.1700, 830.1800) 

Vol. 5 Group B Product Chemistry: Physical-Chemical Properties (OPPTS 830.6302,45601904 

830.6303,830.6304,830.6313,830.7000,830.7050, 830.7200, 830.7300, •••••• 

Vol. 6 

Vol. 7 

Vol. 8 

Vol. 9 

830.7840) •••• 

•• • 

Acute OralToxicity Study in Rats (OPPTS 870.1100) 45601905 : .... 

Acute Dermal Toxicity Study in Rabbits (OPPTS 870.1200) 45601906. ":" 

Acute Inhalation Toxicity Study in Rats (OPPTS 870.1300) 4560 1907 :'::. 

• • •• • Acute Eye lnritation Study in Rabbits (OPPTS 870.2400) 456i:ii908 • 

Vol. 10 Acute Dermallnritation Test in Rabbits (OPPTS 870.2500) 45601909 • ::::. 

•• • •• • 

• •• 

58 
.' "1. 

• 

• 

Smith to Miller 

February 5. 2002 

Page 2 

Vol. ii Skin Sensitization Study in Guinea Pigs (OPPTS 870,2600) 45601910 

Company Official: 

Company Name: 

Company Contact: 

Frederick T. Smith 

SciReg, Inc. 

Frederick T, Smith (703) 494-6500 

" " , , . .. . , 

'''''' , , 

< <" , , 

'" , 

. . " 

59 
• 

MICRO~FLO T~IWlrHw"'M'i'Rorr<:ini COMPANY 

February 1, 2002 

Registration Division 

Office of Pesticide Programs (7504C) 

u. S. EPA 

Ariel Rios Bldg. 

1200 Pennsylvania Avenue, NW 

Nashington, DC 20460 

RE: Thidiazuron 

Dear Sirs, 

This letter is to formally notify the Agency 

authorized to represent Micro Flo Company 

matters related to thidiazuron. 

that SciReg, Inc. is 

in any registration 

Please call if you have any questions related to this matter. 

Regards, 

Morris Gaskins 4It Manager of Registrations 

•••••• 

• •• 

• • 

••• ••• 

• • •• 

••••• 

• • ••••• 

.... 

• • •••• 

•• • 

•• • 

• •• 

• 

• ••• 

• • •••• 

•••• 

• •• 

•• • 

• ••• 

• • •••• 

•• • •• • • •• 

530 Ook Court Drive • Suite 100 • Memphis, TN 38117 • Office: 901-432-5OCO • Fax: 901-432-5100 

60 
... I_rruction. on ,..,.,.. "'0" co fo~. Form A roved. OMS No. 2070-00150 6 

Unitod State. § Registration O?P Identifier Numbor 

&EPA Environmental Protection Agency Amendment 

Washington, DC 20460 269412 Other 

Application for Pesticide - Section ( 

1. Compeny/Product Numbar 2. EPA Product Manager 3. Propo.ed Clas8ificlltion 

51036- t{ IV E' J. Miller ~None o Ro.lricted 4. Company/Product (Name' 

Thidiazuron Technical PM' 23 

5. Namo and Addr ••• of Applicant (Include ZIP Ccd.) S. Expedited Review. In accordance with FIFRA Section 31cH3) 

Micro Flo Co. LLC lbHil, my product is similar or identical in compositron and labeling 

P.O. Box 772099 to: 

Merrphis, TN 38117 EPA Reg. No. 

D Ch(l(;k if this fs • now IJddrf}$.$ Product Name 

Section - II 

0 Amendment - Explain below. 0 Fino! printed labalt: in r.cponG' to 

• 0 Agency lette, dated 

RII$ubmlnion In rDuponSII to Agllncy latter del&d -Me Too" Applicetion. 

0 Notification· Explttin balow. [] Other· explain below. 

Explanation: Un additional pegela) it necassery. IFor IOction I and Section II.) 

Initial application to register. 

Section - III 

1. Mllterh:d T!1;' Product Will Bo Pockoged In: 

Child·Relilililtent Packaging Unit Packaging Waler Soluble Packeging 2. Type of Contairn.r 

W"'· W'" B '0' 

X No X No No §M". Pleatic 

GIOBa 

e;;;catfon must If ·Yee" No. per If -Vos" No.pIH Paper 

Unit Peckeging wgt. contain" Pockoge wgt container X Olher ISpecify) fiber drum 

be submfttod 

I 

3. locotion of Not Contonts Inlonnotion 4. Sinisi Reteil Containor 5. locotion of Lebo! Directions 

[] o Container ~ DnLabel """I 50 Kq On LaboUng accompanying product 

S. Mannor in Which Lobel i. Affix&d to Product :x:: lithograph 0 Othor 

Popar ~IUed 

Stenci ix:l 

Section - IV •••• 

I. Contect Point (Camplets irflfflS directty billow for identificsrfon of individual ro b. contscfed, if nlltcessery, ro procs&S rhis spp'i't:lt'Ion.J 

Namo Titlo Telephone I{o. '!.N:lt!de A,.o Code) 

Morris Gaskins Manager of Registrations • ,9QI. )432-5= 

• • • 

Certification •••••• 6~ P,te.Applicotion 

I coTtily that th" ststamanlS I havo mado on this form and aU attachments thorato ere tf\lO, occureto end comPw:. Roceivod 

• ••• 

lacknowledge that any knowingly lolso or misloading stalamont m&ybe p!Jnishable by fine or imprisonme~W •• • •• 1sC:amped) both undar t1Pplicable low. • • 

••••• • 

2. Signoture /1vv-f; /1./-, 

3. Title •••• • • •••• 

/0' p 

Manager of Registrations ., • 

• • • • •• 

4. TYI,.d Nama lis 5. Dote 

Morris Gaski 2-)}>~ 61 

EPA Form 8570-1 IRev. 8-94) ProVlou, edlbOnt ore ob,oleto. 
PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

PAPERWQRK REDUCTION ACT NOTICE: Public reporting burden for this collection of informetion;$ e&timoted to eller"l1o 0.85 hour per 

re!>ponse, including tirnlll for roviewing instructlO~fching existing doUil sources, gethering end maintaining tho daw Medad, and complating end 

reviowing the collection of information. Send c~1')t$ regarding the burden &stimeto or ony other upect of this collection of information, including 

sugg.,rtionll for reducing this burden, to Ch,of, Informntion Policy Brench, 12136), U.S. Environment".! Protection Ag,,"cy, 40t M Street, SW, 

W8shinqton, DC 20460. 

INSTRUCTIONSi Thili form is to be used for ell applications for new rogisttation, end use reregistration, emendment, IlIsubmilulion, to epplicetiol1l 

for notiftcations, finel printed laboling, raregistration, etc. In ordar to ptocess on application for 8 now registration 3ubmitted on thi3 form, tho 

f<»lol'ting l'IUIteri61 mutt aceompany the eppIieation: 

t. Cartifiootion with RfJl~pwt to Citotion of DatolEPA Form 857().29). IIf Mt exemptw by 40 CFR 152.I:I1lb) 14)1: 

2. Confidential Stlrtomont of Formula (EPA Form S57().4j; 

3. Fon-nul~tor'. Exemption SUltlHT!lIInt IEPA Form 8570·27); 

4, Five copla. of draft labeling; 

5. ThtN oopi., of .nv data IlUbmittod; 

6. Authori:etion letter where epplic8blo; 

7. Mtltric~' whore applicable. 

Soominien of Labeling- Leboling should fiat be submitted in the fom"! of draft labels with el1l.lPpilcotionll for new regi~tretion. Such drlllt labelll may bo 

in the form of typad lab&! text on a.s x 11 inch psper for eubmillsion or 0 mookup of W" proposad 10b&l.lf preper"d for mookup, it should be 

comnructad in a wey es to focHitate MOtage in on 8.5 x 11 inch file. Mockup labels significantly smaller than 8.5 x 11 inches ghould bl! mount0d on 8.5 

x 11 inch paplH fOf 3ubmission. 

Submission of O .. t .. - Dotl! submittod in support of thi::: epplicotion must bll submitted in "ccordllnco with PR Notice 86-5. 

SPECIFIC 

ootion, listad 

INSTRUCTIONS: 

in Block A, for which 

PIIIII&e 

you are 

rud 

submitting 

the instructions 

thiG opplication_ 

li&t(ld below 

For applications: 

befor~ complatinu 

::ubmintrd 

thiG 

in 

application. 

connection 

Fimt 

with 

determine 

New Registration 

th" typ" 

IIctions, 

of regietrJltion 

Sections • 

1. III, end IV must be completed by tho applicant. For applicstions submitted in connuction with amllrnj(ld reregistration actions, rosubmiuionc, 

notificotions, reregistrations:, etc., Sections 1. !I, IIInd IV must be cemp/etod by the oppUcant. 

Il\ocl( A - Ch"ck the appropriate ection for which you am Ilubmitting this form. 

SECTION 1- Thi3 section must be completed, as epplicabl€t, for 611 rogistretion eetions. 

1. CompenylProduet Number -Insert your Compony Numbat, if one hllll boon ossianod by EPA. Thi~ number m"y have btton IIssignoo to you o~ a 

bJl3ic registrant, II distributor, or os an estebli.:hment. If your prodUct is ragi=ter,d, insort tha Product Numbar. 

2. EPA Product Manager· 11 known, fin in tho ntune and PM number ot the EPA Product Menager. 

3. PropO$$d Clu"lficllltien· Specify the ptopoeed claceificlltion of this product. 

4. Prodtlct Heme· Enter the complets product nama ef thie pesticide 0$ it will appear on the hlb!tl. The nome must be IIpecific to thia product ollly. 

Duplication of namell is. not pormittod Mnong products of the same company. 00 not include eny brand name or campeny liM dll3igmltioM. 

5. Namo aod AddnlCG of Applicant - Tho oeme of tho firm or per30n end address IIhown in your application is tho person or firm to whwn the 

rl'lglstration will bl'l ill1.lued. If yOl-l1llf1'l Gcting in behnlf of enother party, you mu;.t lIubmit authorizetion from thet porty to ect for thllm in rl'l{,)hmation 

metttHe. An "Pplicant not radding in tha United StMes mlJ1.It h>:lve an eutltori::od agent residing in tho Unitod St>:ltoe to ect for them in nil 

rogistration m>:lUer3. ThO name end complete mailing address of wch an ag~nt must tlccompeny this application. 

6. Expedited Rovlaw· flFflA section 3 Icl :3 18) provide" for expedited taview of applicutions for registration, or tmlendmants to !')xisting rll{listtati. 

tlult ere 3imilar or identic&! to otm.r pntieide ptoducts that are outtently registerod with the EPA. In order for your application to b(l tJliglbl(l fo 

expedited roviaw, you must provido us with th(l EPA Re(fistretion Number end product nlllne of tho product yOl-l believo is !limiler to or idantic"'! 

your product. The product must ba eimilor or idantic&l in both formulation end laulliad Utos. 

SECTION II ~ Thill saction mullt ba oomplotoo for $II applicationo submitted to II/llf:)'nd tho togistration only of 1'1 currently rogilltorod product 

IAmendment), for e rnubmieeiQn in reoponse to on Agoncy hItter, for notifications to tho Agoncy, for the IIubmission of fin$l printod lab&!ing, for 

rarl'lgistrllltion and for eny othar oction thet portain, to a !l:peeiflc EPA-reQI~tered priXfuct. This section Is not to ba usod for 0 MW oppliclltlon for 

regittretion. - --

1. Sub}oct o( submitsion • Chock the appliceble block and provide the Agoncy lettot doto If approptiete. Provide 0 brisf oxplenation of the purposels) 

fot tho submission, liuch as ~thl'l oddition of a cite, post or erop (specifvl~; "IIITIend the Confidential Stetement of Formule by ... "; "reregistration 

submission"; ;&:~e"4118b&l rovi9ion of use directions." Attach II 3(1psrate pege if odditionm spec$' I; neoded . 

•••• 

SECTION 1I11Pnkllgtno and Container Informotionl - This Section mut:t be completed for rill opplications submittod in connection with naw 

rGgicttatkin or ~ie.blo:m,endments. 

1. Typo of Peckaging· Check tiI'''~Nlpriate block if your product will bl'l peckaged in the indiceted pockoging typos. 

Indicate the 3i::.,p' tho indi~utJ p'::keu and number per retllil contolner. 

2. Type of Jt.t~W""f· lroQ",."'.t¥PG of eontain81 In which ptoduct will ba metkotoo. 

3. location of N\t.C5wventa - 11'tIj,j~. the locetion of the not content' lnformotion for your product. 

4. Size lsi of Retf .~ttinef· SeacjfJ'.the net contents af all rOUl!1 eontainetc for your prodUct. 

5. lo ... tfon of Un Dif-eti_ - ~nd'i"tG tho location of the use dlrectiol1$ for your product. 

6. Mal\laf In which kt.b.! is afflx.1 to" produe1 • Indicated thO' mothod ptoduct label i= ettachod to totO'il contei'nu . •••• • • 

SECTION IV ICo·nUc' Paint) - ThiD Sflction must be complatod for oil applicetions for Regi;trfltion Ilctions, i.e .. new products ragistretien, 

ralllJbmi .. lon, "",*"'0G, • '.rogistretion, otc . .. . 1·5. Solf-oxplenetory. 

6. EPA U .. OniV. 
Fo , No. 

, .......... 

. '" . UNITED STATES ENVIRONMENTAL PROTECTION AGENCY Iss:: I ~ , 401 M Street, S.W. - WASHINGTON, D.C. 20460 

Paperwork Reduction Act Notice: The public reporting burden for this collection of inlonnatior. IS estimated to average 1.25 hour.:; per , lind 0.25 hours per response for reregiStration and special ~view activities. inclUding time for reading the instructions and completing the necellSa~, f~~E Sen' 

comments regarding burden estimate or any other aspect of this collection of information, including suggestions for reducing Ihe burden to: Director, 

Information Management Division (2 (37), U.S. Environmental Protection Agency. 401 M Street, S.w.. INashington, DC 20460. 

Do no! send the completed form to this address. 

Certification with Respect to Citation of Data 

Applicant'slRegisttanfs Name, Address, and Telephone Number Micro Flo Co. LLe ::PA Registration Number/File Symbol 

. P.O. Box TN >0' n 51, 

. ~ct~t,1 i and/or representative test compound(s) Date ,.1../; /., 

General Use Pattem(s) (list all those claimed for this product using 40 CFR Part 158) 

Thi"i. ", 

NOTE: If your product is a 100% repackaging of another purchased EPA'registere<l product labeled for all the same uses on your label, you do not need to 

this form. You must submit the Formulator's Exemption Statement (EPA Form 8570-27). 

I am responding to a Data-Call·ln Notice. and have included with this form a list of companies sen! offers of compensation (Ihe Data Matrrx form should 

be used for this purpose). 

SECTION I: METHOD OF DATA SUPPORT (Check one method only) 

tJ I am using the dte-all method of support, and have included with this form 0 I am using the se!ectille method of support (or dte-aB option 

a liSt of companies sent offers of compens3tion (the Data Matrix form under the ~lecti've method), and have included with this 101m a 

should be used for this purpose). HSt of data requirements (the Data Matrtx form must be 

"''''I. 

SECTION It: GENERAL OFFER TO PAY 

[ReqUired if usmg the cite-all method or when using the cite-all option under the selective method to satisfy one or more data requirements] 

EJ I hereby offer and agree to pay compensation, to other persons, w~h regard to the approval of this application, to the extent required by FIFRA 

. 

SECTION III: CERTIFICATION 

~ certify that th'ls appHC0100n for registration, this form for rere~l"l$tration, Q( th'l$ DattrCalf.ln response 'IS supported by all data . . I 

. for registration, the form for reregistration, or the Data-Cali-In response. In addition, if the cite-all option or dte-all option 

:i'i~Section I. this application is supported by aU data In the Agency's files thlllt (t) concern the properties or effects of this product or an identicat or 

~ s,~!! ~roduct. Of one or more of the ingredients in this product and (2) is a type of data that would be reqUIred to be submitted under the data 

the date of approval of this application if the application sought the initial regtstratbn of a product of identical or smilar compooman and ,_. 

the' I certify that for each exclusive use study cited in support of this regIStration or reregistration, thill I am the onglnal data submitter or that I i 

written permission of the original data submitter to cite that study. 

I certify that for each study cited in support of this registration or reregistration that is not an exclusive use study. either: (a) I.M !l1b.Original data 

submitter; (b) I have obtained the permission of the original data submitter to use the study in support of this application: (c) all periods ofellgibility for 

compensation have expired fur the study: (d) the study is in Ihe public literalure: or (e) I have notified in writing Ihe company that subm*1td tl'ti! study and have 

offered (I) to pay compoosation to the extent required by sections 3(c)(t)(F) and/or 3fc)(2)(B) of FIFRA: and (ii) to commence negotiat~nl\llol!etermine the 

amount and terms of compensation, if any, to be paid for the use of the study. ....... • 

• • • 

I certify that in all instances where an offer of compensation is required, COPieS of all offers to pay compensatfon and·eviden()£>·~'trQjr delivery in 

accordance with sections 3(c)(1)(F) and/or 3(cl(2)(B) of FIFRA am available al'ld will be submitted to the Agency upon f~Mt! Should' M'il"!:o produce such . 

evidence to the Agency upon request, I understand that the Agency may inruate action to deny, cancel or ~uspend the registr8tion of ~~ in conformity wi 

FIFRA. ...... ••• 

• • ••••• • 

t certify that the st:ltements I have made on this fonn and all attachments to tt arc true, accurate, and comptete. I ac\iModgo that any 

knowingly "hllse or misleading statement may be punishable by fine or imprisonment or both under applicable law. • • •••• 

Signature 

/'l1 .--.-.z A ,,-

Date 

/ i" ~d qr Prrnted N~me and ;'H~·· • rrlS Gaskins , ,f . <-

",."" / 

"'Pee ",m,,,, " 

, 5",,,,, ,,' , , 63 
• • f-orrn Approved OMS No 2070 0060 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

401 M Street, S.W. 

WASHINGTON, DC 20460 

'c -- ------- ----- ---------- ---------------- ------ -------------- -__ ___ __ _______ __ Pape!work Reduction Act NotICe: The public repoitlng burden for UllS collection r:i Information IS estimated to average 0.25 hours per response for registration actlvltles and 0.25 hours per 

restXJnse for reregistration and special reView actIVities, including time for reading the Instructions and completing the necessary forms. Send comments regarding the burden estimate or 

any other aspect of this collection of information, including suggestions for redudng the burden to: Director, OPPE Information Management Division (2137) U.s. Environmental Protection 

,_Agen0', 401 M Str_~t, S.:~:!,Washington, DC 2.9460. Do not send th~ form to this address. 

DATA MATRIX 

;1-/, Ii>;;' - Date: EPA Reg No,/Fite Symbol 51036-appl. Page 1 of 1 

Appticant's/Regiirant's Name & Address: Micro Flo Compan-y--- Product: 

P.O. Box 772099 Memphis, TN 38117 THIDIAZURON TECHNICAL 

Ingredient: Thidiazuron CAS # 51707"55-2 

Guideline Reference Number Guideline Study Name MRID Number Submitter Status Note 

830 Group A Product Identity, Composition and AnalYSis Micro Flo Co. LLC Submitted with app!. 

830 Group B Physical/Chemical Properties Micro Flo Co. llC Submitted with app/. 

GENERIC DATA 

CITE All. Uniroyal Chemical Co. PAY 

CITE All. Nor-Am Chemical Co. PAY 

CITE All. Spay Drift Task. Force PAY 

CITE ALL Agricultural Re-Entry Task Force PAY 

CITE All. Aventis OupSdence USA PAY 

870.1100 Acute oral toxicity IM-' ~'n ~n LL~ ", . tb appl 

Acute dermal toxicity • • • •• 870.1200 • • • ~'n ~n LL~ SUbm. with apol. • 

• •• •• 870.1300 Acute ~'n ~n LL~ ~ubm. with appl. inhalation toxicity.." "" • • •• 

870.2400 Eye irritation Micro Flo Co. LLC ~ubm. with appl. 

••• • • • '" • b"hm ''" 870.2500 In . , . -, ,h" ••• • • • ••• " • • • -I,Ln • ••• •• • •• • • 

Dermal sensitization ••• 6ubm. with aool. • • • • • • .Jl2Q. 2600 ___ l'licro Flo Co • LLC ••• • • • 

fignature Name and TItle: Morris Gaskins Date 

/VJ~~ .. Manager of Registrations 

--.~ .. _------------ _~,.JAJ-. EPA Form 8570-35 (9-97) Electroni( and Paper versions a¢ilable. 'Submit only Paper Vision. . Agency Internal Use Copy o 5a~M.-J;;~/~3 
• • Form Approved OMB No. 2070-0060 

UNITED STATES ENVIRONMENTAL PROTECITON AGENCY 

401 M Street, S.W. 

WASHINGTON, DC 20460 

Paperwork ReductIOn Act Notice 

response for reregistration and 

he public reporting burden for thl's-collectK;;;-(;r~for;;:;a-b-o~i iSeSi-,~;';ted~'toa~e~age 0 .is-Ilours-pe"f' respOn'sefor 7egii;:.3tiO'n aCtivities a'nd'o.2S-h-ourspe-r--

:ial review activities, Indudlng time for reading the instructions and completing the necessary forms. Send comments regarding the burden estimate or 

any other aspect of this colledio: 

.J~gen9:,!,_'!Q!:..!'!...~~~1.~W.~.,~, 

f information, including suggestions for reducing the burden to: Olrector, QPPE Information Management Division (2137) U.s. Environmental Protection 

19too, ~ __ .?g460. ~0't send the form to this address . -

- "-"-

-

~~~-~---------'" 

lAddress: Micro Flo Company 

--~---

Date: b,. _",j ~ 

Applicant's/Regi ant:.i. 

P.O. Box 772099 

Ingredient: Thidiazuron CAS 5 # 51707-55-2 

Guidelrne Reference Numbe , I Guideline study Name 

DATA MATRIX 

-------, 

Memphis, TN 38117 

-

MRID Number 

• • • ••• • • • • ••• •• • 

• • • • •• 

• • • • • 

• • •••• 

• •• • • • .. . • ••• • • • • • • • • • • • • • • • • • • • • •••••• • • • ••• • •• • ••• 

-.,._--_. • - ... • ~ 

Signature 

':A'"ocm8576C35(9'97)'Elewon"""dPo-",,,Q"'ble. Submit only Paper Vision. "'~-----------,---

EPA Reg No./File Symbol 51036-appl. iPagelofl .- Product: 

THIDIAZURON TECHNICAL 

Submitter Status Note 

Micro Flo Co. LLC Submitted with appl. 

Micro Flo Co. LLC Submitted with appl. 

Uniroyal Chemical Co. PAY 

Nor~Am Chemical Co. PAY 

Spray Drift: Task Force PAY 

Agricultural Re-Entry Task Force PAY 

Aventis CropSdence USA PAY 

Micro Flo Co. LLe . ch .nnl 

Micro Flo Co. LLe subm. with appl. 

Micro Flo Co. LLe subm. with appl. 

Micro Flo Co. LLe subm. with appl. 

tHcro Flo Co • LLe subm with aool. 

Micro Flo Co. LLe subm. with annl. 

Name and TItle: Morris Gaskins Da" 

Manager of Registrations i/YOLAgency Public Record Copy 

L--__________________________ --
Pages 66-67 - *Confidential Statements of Formula may be entitled to confidential treatment*