Exhibit 10.15 


 





SUBSCRIPTION
AGREEMENT


 


This
SUBSCRIPTION AGREEMENT (this “Agreement”) is made as of the latest date set
forth on the signature page hereof between Fennec Pharmaceuticals Inc. (the “Company”) and the undersigned
(the “Subscriber”).


 


W I T N E S
S E T H:


 


WHEREAS
the Company desires to offer and issue for sale on a private placement basis (the “Offering”) up to 2,000,000
common shares in the capital of the Company (the “Shares”) at a price per Share of USD$4.00 and representing
an aggregate purchase price of up to USD$8,000,000, anticipated to occur on or about June 8, 2017 or such later date on which
all regulatory and other approvals necessary to complete the Offering have been obtained (the “Closing”). A
summary of the terms of the Offering is set forth in Schedule “A” to this Agreement. Such summary is qualified
in its entirety by the terms and conditions set forth in this Agreement; and


 


WHEREAS
unless otherwise stated, all dollar amounts in this Agreement refer to United States Dollars; and


 


WHEREAS,
the Subscriber desires to purchase Shares on the terms and conditions hereinafter set forth.


 


NOW,
THEREFORE, in consideration of the premises and the mutual representations and covenants hereinafter set forth, the parties hereto
do hereby agree as follows:


 


		I.	SUBSCRIPTION
                                         FOR SHARES AND REPRESENTATIONS BY SUBSCRIBER



 


1.1                    
Subject to the terms and conditions hereinafter set forth, the Subscriber hereby irrevocably purchases for itself and agrees
to purchase from the Company, and the Company agrees to sell to the Subscriber, the Shares for an aggregate purchase price equal
to USD$                  (the “Purchase
Price”). The Purchase Price is payable by wire transfer of immediately available funds at the time of entering into
this Agreement to an account designated by LaBarge Weinstein LLP, counsel to the Company (“Company Counsel”),
to be held in escrow and shall be released at the Closing by Company Counsel to an account designated by the Company in accordance
with the terms and conditions of this Agreement. In the event that the Closing does not occur as contemplated by the terms of
this Agreement, Company Counsel shall return the Purchase Price held in escrow to the Subscriber by means of wire transfer of
immediately available funds within two (2) business days of such determination.


 


1.2                    
The Subscriber hereby warrants and represents that it recognizes that the purchase of the Shares involves a high degree
of risk including, but not limited to, the following: (a) an investment in the Company is highly speculative and only investors
who can afford the loss of their entire investment should consider investing in the Company and the Shares; (b) the Subscriber
may not be able to liquidate its investment; and (c) transferability of the Shares is limited.


 


1.3                    
The Subscriber represents that it (i) is an “accredited investor” as such term is defined in Rule 501(a) of
Regulation D promulgated under the Securities Act of 1933, as amended (the “Act”), as indicated by the
Subscriber’s responses to the questions contained in Article IX hereof, and by reason of its business and financial experience
and the business and financial experience of those persons it may have retained to advise it with respect to its investment in
the Shares it, together with such advisors, has such knowledge, sophistication and experience in business and financial matters
that it is capable of evaluating the merits and risks of the prospective investment; (ii) is an “accredited investor”
as such term is defined in National Instrument 45-106 – Prospectus Exemptions, of the Canadian Securities Administrators
and the Subscriber has completed the Accredited Investor Certificate attached hereto as Schedule “C” and (iii)
complies with the requirements of all applicable securities laws in its jurisdiction that is other than the United States and
Canada (the “International Jurisdiction”) and has completed the Accredited Investor Certificate attached hereto
as Schedule “D”.


 






     


     


    

  


1.4                    
The Subscriber hereby acknowledges and represents that: (a) the Subscriber has knowledge and experience in business and
financial matters, prior investment experience, including investment in securities that are unregistered, or the Subscriber, at
its own risk and expense, has employed the services of a “purchaser representative” (as defined in Rule 501(h) of
Regulation D), attorney and/or accountant to read all of the documents furnished or made available by the Company to the
Subscriber to evaluate the merits and risks of such an investment on the Subscriber’s behalf; (b) the Subscriber recognizes
the highly speculative nature of this investment; and (c) the Subscriber is able to bear the loss of its entire investment.


 


1.5                    
The Subscriber represents that (i) the Subscriber was contacted regarding the sale of the Shares by the Company, or a Company
agent, with whom the Subscriber had a prior substantial pre-existing relationship and (ii) no Shares were offered or sold to it
by means of any form of general solicitation or general advertising, and in connection therewith, the Subscriber did not receive
any general solicitation or general advertising including, but not limited to: (A) any advertisement, article, notice or other
communication published in any newspaper, magazine or similar media or broadcast over television or radio, whether closed circuit,
or generally available; or (B) through attendance at any seminar meeting or industry investor conference whose attendees were
invited by any general solicitation or general advertising.


 


1.6                    
The Subscriber hereby acknowledges that the Offering has not been reviewed by the United States Securities and Exchange
Commission (the “SEC”) nor any U.S. state or Canadian provincial securities regulatory authority (“Securities
Regulatory Authority”) as the Offering is intended to be exempt from the registration requirements of Section 5 of the
Act, pursuant to Regulation D thereunder and from the registration requirements of applicable state “blue sky”
securities laws or regulations. The Subscriber understands that the Shares have not been registered under the Act or under any
U.S. state or Canadian provincial securities or “blue sky” laws or regulations by reason of a claimed exemption that
depends, in part, upon the Subscriber’s investment intention and agreement not to sell, pledge, assign or otherwise transfer
or dispose of the Shares unless they are registered under the Act and under any applicable state securities or “blue sky”
laws or regulations or unless an exemption from such registration is available, subject to Section 1.10 herein. Without limiting
the foregoing, the Company acknowledges and agrees that a Subscriber may from time to time pledge pursuant to a bona fide margin
agreement with a registered broker-dealer or grant a security interest in some or all of the Shares to a financial institution
that is an “accredited investor” as defined in Rule 501(a) under Regulation D and who agrees to be bound by the provisions
of this Agreement and, if required under the terms of such arrangement, such Subscriber may transfer pledged or secured Shares
to the pledgees or secured parties. Such a pledge or transfer would not be subject to approval of the Company and no legal opinion
of legal counsel of the pledgee, secured party or pledgor shall be required in connection therewith. Further, no notice shall
be required of such pledge. At the Subscriber’s expense, the Company will execute and deliver such reasonable documentation
as a pledgee or secured party of the Subscriber may reasonably request in connection with a pledge or transfer of the Shares.


 


1.7                    
The Subscriber hereby represents that the Subscriber is purchasing the Shares for the Subscriber’s own account and
not with a view toward the resale or distribution to others. The Subscriber, if an entity, further represents that it was not
formed for the purpose of purchasing the Shares.


 






     


     


    

 


1.8                    
The Subscriber understands that Rule 144 (“Rule 144”) promulgated under the Act requires for non-affiliates,
among other conditions, a one (1) year holding period prior to the resale in the United States of securities of an issuer that
is not a reporting issuer under the Securities Exchange Act of 1934, as amended, acquired in a non-public offering without having
to satisfy the registration requirements under the Act. The Subscriber understands and hereby acknowledges that except as set
forth herein the Company is under no obligation to register any of the Shares under the Act or any state securities or “blue
sky” laws.


 


1.9                    
The Subscriber further understands and agrees that it shall not sell the Shares to a purchaser in any province of Canada
at any time within the four (4) month period following the date of their issuance and any subsequent purchaser outside of Canada
before the end of that period must agree to comply with this restriction for the remainder of such period. The Subscriber further
agrees that if it decides to offer, sell or otherwise transfer, pledge or hypothecate all or any part of the Shares, it will not
offer, sell or otherwise transfer, pledge or hypothecate any of such Shares (other than pursuant to an effective registration
statement under the Act), directly or indirectly unless an offer and sale or other disposition is:


 


(a)       
made in accordance with an effective registration statement under the Act covering such disposition; or


 


(b)      
to the Company; or


 


(c)       
made outside the United States in accordance with the requirements of Rule 904 of Regulation S under the Act;
or


 


(d)      
made in a transaction that does not require registration under the Act or any applicable United States state laws, rules
and regulations governing the offer and sale of securities, and it has theretofore furnished to the Company an opinion of counsel
to that effect; provided, that no opinion shall be required for any sale pursuant to Rule 144, or pursuant to any bona fide pledge
in connection with a margin account. 


 


1.10                
The Subscriber consents to the placement of a legend on any certificate or other document evidencing the Shares indicating
that such Shares have not been registered under the Act or any state securities or “blue sky” laws and setting forth
or referring to the restrictions on transferability and sale thereof contained in this Agreement. The Subscriber is aware that
the Company will make a notation in its appropriate records with respect to the restrictions on the transferability of such Shares.
The legend to be placed on each certificate shall be in form substantially similar to the following:


 


UNLESS
PERMITTED UNDER SECURITIES LEGISLATION, THE HOLDER OF THIS SECURITY MUST NOT TRADE THE SECURITY BEFORE [INSERT THE DATE THAT
IS FOUR MONTHS AND A DAY AFTER THE DISTRIBUTION DATE].


 


THE
SECURITIES REPRESENTED BY THIS CERTIFICATE ARE LISTED ON THE TORONTO STOCK EXCHANGE (“TSX”); HOWEVER, THE SAID SECURITIES
CANNOT BE TRADED THROUGH THE FACILITIES OF TSX SINCE THEY ARE NOT FREELY TRANSFERABLE, AND CONSEQUENTLY ANY CERTIFICATE REPRESENTING
SUCH SECURITIES IS NOT “GOOD DELIVERY” IN SETTLEMENT OF TRANSACTIONS ON TSX.


 


THE SECURITIES
REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”).
THE HOLDER HEREOF, BY PURCHASING SUCH SECURITIES, AGREES FOR THE BENEFIT OF THE ISSUER THAT SUCH SECURITIES MAY BE OFFERED, SOLD
OR OTHERWISE TRANSFERRED ONLY (A) TO THE ISSUER, (B) OUTSIDE THE UNITED STATES IN ACCORDANCE WITH RULE 904 OF REGULATION S UNDER
THE ACT, OR (C) IN ACCORDANCE WITH AN EFFECTIVE REGISTRATION STATEMENT OR PURSUANT TO ANOTHER EXEMPTION FROM REGISTRATION AFTER
PROVIDING A REASONABLY SATISFACTORY LEGAL OPINION TO THE ISSUER.


 






     


     


    

 


Provided
that if the Shares are being sold pursuant to Section 1.9(c) above,
in the case of a resale to a purchaser in Canada, following the date which is four (4) months and a day after the date of issuance
to the Subscriber, the Company covenants and represents that the legend may be removed by providing a declaration to the transfer
agent for the Shares of the Company substantially as attached hereto as Schedule “B” (or as the Company may
prescribe from time to time) upon the sale of the Shares by the Subscriber.


 


1.11                
The Subscriber understands that the Company, at its sole discretion, reserves the unrestricted right, without further documentation
or agreement on the part of the Subscriber, to reject or limit any purchase, to accept purchases for fractional Shares and to
close the Offering to the Subscriber at any time and that the Company will issue stop transfer instructions to its transfer agent
with respect to such Shares.


 


1.12                
The Subscriber hereby represents that the address of the Subscriber furnished by Subscriber on the signature page hereof
is the Subscriber’s principal residence if the Subscriber is an individual or its principal business address if it is a
corporation or other entity and that Subscriber is not resident in any province of Canada. If the Subscriber is resident outside
of the United States, the Subscriber hereby represents that the Subscriber is resident in the jurisdiction specified in the address
set out on Subscriber’s signature page to this Agreement (the “International Jurisdiction”) and that:


 


(a)       
the Subscriber is knowledgeable of, or has been independently advised as to, the applicable securities laws of the International
Jurisdiction which would apply to this subscription, if there are any;


 


(b)      
the securities laws of the International Jurisdiction applicable to the Subscriber do not require the Company to file a
prospectus or similar document or to register the Shares or to make any filings or seek any approvals of any kind whatsoever in
respect of the sale of the Shares to the Subscriber from any regulatory authority in the International Jurisdiction;


 


(c)       
the delivery of this Agreement by the Company and the Subscriber and the issuance of the Shares to the Subscriber complies
with all applicable securities laws of the International Jurisdiction and will not cause the Company to become subject to any
disclosure, prospectus, registration or reporting requirements under any such securities laws; and


 


(d)      
the Subscriber will, if requested by the Company, deliver to the Company a certificate or opinion of local counsel from
the International Jurisdiction which will confirm the matters referred to in subparagraphs (b) and (c) above to the satisfaction
of the Company, acting reasonably.


 


1.13                
The Subscriber represents that the Subscriber has full power and authority (corporate, statutory and otherwise) to execute
and deliver this Agreement and to purchase the Shares. This Agreement constitutes the legal, valid and binding obligation of the
Subscriber, enforceable against the Subscriber in accordance with its terms, subject to laws of general application relating to
bankruptcy, insolvency and the relief of debtors and rules of law governing specific performance, injunctive relief or other equitable
remedies, and to limitations of public policy.


 






     


     


    

 


1.14                
If the Subscriber is a corporation, partnership, limited liability company, trust, employee benefit plan, individual retirement
account, Keogh Plan, or other tax-exempt entity, it is authorized and qualified to invest in the Company and the person signing
this Agreement on behalf of such entity has been duly authorized by such entity to do so.


 


1.15                
The Subscriber is not a Registered Representative of a Financial Industry Regulatory Authority (“FINRA”)
member firm.


 


1.16                
 


(a)       
The Subscriber agrees not to issue any public statement with respect to the Subscriber’s investment or proposed investment
in the Company or the terms of any agreement or covenant between them and the Company without the Company’s prior written
consent (which consent shall not be unreasonably withheld, conditioned or delayed), except such disclosures as may be required
under applicable law or under any applicable order, rule or regulation.


 


(b)      
The Subscriber acknowledges that this Agreement requires the Subscriber to provide certain personal information to the
Company. Such information is being collected by the Company for the purposes of completing the Offering, which includes, without
limitation, determining the Subscriber's eligibility to purchase the Shares under applicable securities laws, preparing and registering
certificates representing the Shares to be issued to the Subscriber and completing filings required by any Securities Regulatory
Authority. The Subscriber’s personal information may be disclosed by the Company to: (a) any applicable Securities Regulatory
Authority; (b) the Company's registrar and transfer agent; (c) Canada Revenue Agency; (d) any applicable stock exchange or over-the-counter
market (including the TSX); and (e) the Company’s advisors, including legal counsel, and may be included in record books
in connection with the Offering. By executing this Agreement, the Subscriber is deemed to be consenting to the foregoing collection,
use and disclosure of the Subscriber's personal information.


 


(c)               
The Subscriber consents to the filing of copies or originals of any of the Subscriber’s documents described in Section
1.16(b) hereof as may be required to be filed with any Securities
Regulatory Authority in connection with the transactions contemplated hereby.


 


(d)               
If the Subscriber is a resident of or otherwise subject to applicable securities laws of Ontario, the Subscriber acknowledges
that it has been notified by the Company (a) of the delivery to the Ontario Securities Commission (the “OSC”)
of the full name, residential address and telephone number of the Subscriber, the number and type of securities purchased, the
total purchase price, the exemption relied upon and the date of distribution; (b) that this information is being collected indirectly
by the OSC under the authority granted to it under applicable securities laws; (c) that this information is being collected for
the purposes of the administration and enforcement of the Securities Law of Ontario; and (d) that the Administrative Assistant
to the Director of Corporate Finance can be contacted at Suite 1903, Box 55, 20 Queen Street West, Toronto, Ontario M5H 3S8 or
at (416) 593-8086 regarding any questions about the OSC’s indirect collection of this information and further acknowledges
that it has authorized the indirect collection of this information by the OSC.


 


(e)               
The Subscriber represents and warrants that the funds representing the aggregate Purchase Price which will be paid by the
Subscriber to the Company for the Shares hereby subscribed for will not represent proceeds of crime for the purposes of the Proceeds
of Crime (Money Laundering) and Terrorist Financing Act (Canada) (the “PCMLA”) and the Subscriber acknowledges
that the Company may in the future be required by law to disclose the Subscriber's name and other information relating to this
Agreement and the Subscriber’s subscription hereunder, on a confidential basis, pursuant to the PCMLA. To the best of its
knowledge (a) none of the subscription funds to be provided by the Subscriber (i) have been or will be derived from or related
to any activity that is deemed criminal under the law of Canada, the United States of America, or any other jurisdiction, or (ii)
are being tendered on behalf of a person who has not been identified to the Subscriber, and (b) it shall promptly notify the Company
if the Subscriber discovers that any of such representations ceases to be true, and to provide the Company with appropriate information
in connection therewith.


 






     


     


    

 


1.17                
The Subscriber represents and warrants that it has not engaged, consented to or authorized any broker, finder or intermediary
to act on its behalf, directly or indirectly, as a broker, finder or intermediary in connection with the transactions contemplated
by this Agreement. The Subscriber hereby agrees to indemnify and hold harmless the Company from and against all fees, commissions
or other payments owing to any such person or firm acting on behalf of the Subscriber hereunder.


 


1.18                
The Subscriber agrees to hold the Company and its directors, officers, employees, affiliates, controlling persons and agents
and their respective heirs, representatives, successors and assigns harmless and to indemnify them against all liabilities, costs
and expenses incurred by them as a result of (a) any sale or distribution of the Shares by the Subscriber in violation of the
Act or any applicable state securities or “blue sky” laws; or (b) any false representation or warranty or any breach
or failure by the Subscriber to comply with any covenant made by the Subscriber in this Agreement (including the Confidential
Investor Questionnaire contained in Article IX herein) or any other document furnished by the Subscriber to any of the foregoing
in connection with this transaction.


 


1.19                
The Subscriber understands, acknowledges and agrees with the Company that, except as otherwise set forth herein, the subscription
hereunder is irrevocable by the Subscriber, that, except as required by law, the Subscriber is not entitled to cancel, terminate
or revoke this Agreement or any agreements of the Subscriber hereunder and that this Agreement and such other agreements shall
survive the death or disability of the Subscriber and shall be binding upon and inure to the benefit of the parties and their
heirs, executors, administrators, successors, legal representatives and permitted assigns. If the Subscriber is more than one
person, the obligations of the Subscriber hereunder shall be joint and several and the agreements, representations, warranties
and acknowledgments herein contained shall be deemed to be made by and be binding upon each such person and his/her heirs, executors,
administrators, successors, legal representatives and permitted assigns.


 


1.20                
The Subscriber understands, acknowledges and agrees with the Company that the Offering is intended to be exempt from registration
under the Act pursuant to the provisions of Regulation D thereunder, which is in part dependent upon the truth, completeness
and accuracy of the representations made by the Subscriber herein.


 


1.21                
The Subscriber acknowledges that the information contained in this Agreement or otherwise made available to the Subscriber
is confidential and non-public and agrees that all such information shall be kept in confidence by the Subscriber and neither
used by the Subscriber for the Subscriber’s personal benefit (other than in connection with this Agreement, as supplemented)
nor disclosed to any third party for any reason, unless such disclosure is required by applicable law or a court judgment, order
or decree, notwithstanding that the Subscriber’s subscription may not be accepted by the Company; provided, however, that
this obligation shall not apply to any such information that (i) is part of the public knowledge or literature and readily
accessible at the date hereof, (ii) becomes part of the public knowledge or literature and readily accessible by publication
(except as a result of a breach of this provision) or (iii) is received from third parties (except third parties who disclose
such information in violation of any confidentiality agreements or obligations, including, without limitation, any subscription
or other similar agreement entered into with the Company).


 


1.22                
The Subscriber understands, acknowledges and agrees with the Company that: (a) the Company may terminate the Offering or
reject any subscription at any time in its sole discretion and the execution of this Agreement by the Subscriber or solicitation
of the investment contemplated hereby shall create no obligation on the part of the Company to accept any subscription or complete
the Offering; (b) no federal, provincial or state agency or authority has made any finding or determination as to the accuracy
or adequacy of the Offering documents or as to the fairness of the terms of the Offering nor any recommendation or endorsement
of the Shares (any representation to the contrary is a criminal offense); and (c) in making an investment decision, the Subscriber
must rely on its own examination of the Company and the terms of the Offering, including the merits and risks involved.


 






     


     


    

  


		II.	REPRESENTATIONS
                                         AND WARRANTIES OF THE COMPANY



 


In the event that
the Company accepts the Subscriber’s subscription of Shares hereunder, the Company hereby represents and warrants to the
Subscriber that:


 


2.1                    
Organization, Good Standing and Qualification. The Company is a corporation duly organized, validly existing and
in good standing under the laws of British Columbia and has full corporate power and authority to own, lease and operate its property
and assets, and to conduct its business as now conducted. The Company has conducted and is conducting its business in compliance
in all material respects with all applicable laws, rules and regulations of the jurisdictions in which it carries on business.


 


2.2                    
Capitalization and Voting Rights. The Company is authorized to issue an unlimited number of common shares in the
capital of the Company (the “Common Shares”). As of June 6, 2017, the Company had 13,707,306 Common Shares
issued and outstanding, and all issued and outstanding shares of the Company are validly issued, fully paid and non-assessable.
As of June 6, 2017, the Company had: (i) warrants to purchase a total of 1,383,331 Common Shares outstanding and (ii) 2,412,711
options outstanding. Other than as set forth in the preceding sentence, there are no outstanding options, warrants, agreements,
convertible securities, preemptive rights or other rights to subscribe for or to purchase any shares in the capital stock of the
Company. Except as required by law, there are no restrictions upon the voting or transfer of any of the shares in the capital
stock of the Company pursuant to the Company’s notice of articles as amended to date or any agreement or other instruments
to which the Company is a party or by which the Company is bound.


 


2.3                    
Authorization; Enforceability. The Company has all corporate right, power and authority to enter into this Agreement
and to consummate the transactions contemplated hereby. All corporate action on the part of the Company and its directors necessary
for the (i) authorization, execution, delivery and performance of this Agreement by the Company; and (ii) authorization,
sale, issuance and delivery of the Shares contemplated hereby and the performance of the Company’s obligations hereunder
has been taken or will be taken prior to the Closing (in accordance with Section 3.2). This Agreement has been duly executed and
delivered by the Company and constitutes a legal, valid and binding obligation of the Company, enforceable against the Company
in accordance with its terms, subject to laws of general application relating to bankruptcy, insolvency and the relief of debtors
and rules of law governing specific performance, injunctive relief or other equitable remedies, and to limitations of public policy.
The Shares, when issued and fully paid for in accordance with the terms of this Agreement, will be validly issued, fully paid
and non-assessable. The issuance and sale of the Shares contemplated hereby will not give rise to any preemptive rights or rights
of first refusal on behalf of any person which have not been waived in connection with this Offering.


 






     


     


    

 


2.4                    
No Conflict; Governmental Consents.


 


(a)               
The execution and delivery by the Company of this Agreement and the consummation of the transactions contemplated hereby
will not result in the violation of any material law, statute, rule, regulation, order, writ, injunction, judgment or decree of
any court or governmental authority to or by which the Company is bound, or of any provision of the articles of amalgamation,
as amended, of the Company, and will not conflict with, or result in a material breach or violation of, any of the terms or provisions
of, or constitute (with due notice or lapse of time or both) a default under, any lease, loan agreement, mortgage, security agreement,
trust indenture or other agreement or instrument to which the Company is a party or by which it is bound or to which any of its
properties or assets is subject, nor result in the creation or imposition of any lien or encumbrance upon any of the properties
or assets of the Company.


 


(b)               
No consent, approval, authorization or other order of any United States or Canadian governmental authority is required
to be obtained by the Company in connection with the authorization, execution and delivery of this Agreement or with the authorization,
issue and sale of the Shares, except such consents and filings as may be required to be made with or obtained from the SEC, FINRA,
the TSX, the OTCOB and with any state or foreign blue sky or other Securities Regulatory Authority and any Canadian Securities
Regulatory Authority, all of which filings or consents, including the TSX Approval (as defined herein), have been or will be timely
made or obtained on or prior to Closing (for the avoidance of doubt, other than as set forth in Section 2.9).


 


2.5                    
Litigation. There is no pending or, or to the knowledge of the Company, threatened legal or governmental proceedings
against the Company. The Company is not a party or subject to the provisions of any order, writ, injunction, judgment or decree
of any court or government agency or instrumentality. There is no action, suit, proceeding or investigation by the Company currently
pending in any court or before any arbitrator or that the Company intends to initiate.


 


2.6                    
Approvals. The Company will obtain, prior to the Closing, the receipt of all required third party and regulatory
approvals, as applicable, including, without limitation, the TSX Approval and no shareholder approval is required for the Company
to issue the Shares.


 


2.7                    
Financial Statements. The most recent annual financial statements of the Company as filed under the Company’s
issuer profile on www.sedar.com as of the date hereof (collectively, the “Financial Statements”) accurately
present fairly the financial position and condition, the results of operations and cash flows of the Company as at the dates and
for the periods indicated thereof, have been prepared in conformity with generally accepted accounting principles in the United
States, applied on a consistent basis throughout the periods involved, except as otherwise stated therein, and no material changes
in such positions have taken place since the dates and for the periods indicated thereof, save in the ordinary course of the Company’s
business or as publicly announced.


 


2.8                    
Reporting Issuer in Canada; Absence of Material Changes. The Company is a reporting issuer or the equivalent thereof
in British Columbia, Alberta, Saskatchewan, Manitoba, Ontario, Quebec, New Brunswick, Nova Scotia, Prince Edward Island and Newfoundland,
and is not in default of any requirement under applicable securities legislation, statutes, regulations, and published policies
and rules of Canadian provincial securities and TSX regulations, and, in particular, without limiting the generality of the foregoing,
the Company is in compliance with its obligations to make all reports and filings, including timely disclosure of all material
changes relating to it, under such applicable securities legislation, statutes, regulations, and published policies and rules
of Canadian provincial securities laws (“Filings”), no such disclosure has been made on a confidential basis
and there is no material change relating to the Company which has occurred and with respect to which the requisite material change
report has not been filed. The Filings complied in all material respects with the requirements of applicable securities legislation,
statutes, regulations, and published policies and rules of Canadian provincial securities and TSX regulations. The Filings, as
of their respective dates, did not contain any untrue statement of material fact or omit any material fact required to be stated
therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading.
No securities commission or regulatory authority in any of the provinces of Canada has issued any order preventing or suspending
trading of any securities of the Company. Except as set forth in the Filings, there has not been (i) any material adverse change
or effect on the business, assets, financial condition, prospects or results of operations of the Company (collectively, the “Business”),
(ii) any transaction that is material to the Company, (iii) any obligation, direct or contingent, that is material to the Company,
incurred by the Company or any of its subsidiaries, (iv) any change in the outstanding indebtedness of the Company and its subsidiaries
(taken as a whole) that is material to the Company or the Business, (v) any dividend declared, paid or made on the capital stock
of the Company, or (vi) any loss or damage (whether or not insured) to the property of the Company or any subsidiary which has
been sustained which in the case of this clause (vi), individually or in the aggregate, could reasonably be expected to impair
in any material respect the Company’s ability to enter into and perform on a timely basis its obligations under this Agreement.


 






     


     


    

 


2.9                    
Listing. The common shares of the Company are listed on the TSX. On Closing, the Shares issued hereunder will have
been conditionally approved for listing on the TSX (the “TSX Approval”), subject only to the satisfaction
of customary deliverables after Closing, which the Company will perform in a timely fashion.


 


2.10                
No General Solicitation. Neither the Company nor, to its knowledge, any person acting on its behalf has offered
or sold or will offer or sell the Shares by any form of general solicitation or general advertising, including, but not limited
to, the following:


 


(a)                
any advertisement, article, notice or other communication published in any newspaper, magazine, or similar media or broadcast
over television or radio; and


 


(b)                
any seminar or meeting whose attendees have been invited by any general solicitation or general advertising.


 


2.11                
No Fees. No brokerage, agency, finder or other fiscal advisory or similar fee is payable by the Company in connection
with the transactions contemplated herein.


 


2.12                
Investment Company. The Company is not an “investment company” within the meaning of such term under
the Investment Company Act of 1940, as amended, and the rules and regulations of the SEC thereunder.


 


2.13                
Disclosure. The representations and warranties made by the Company in this Agreement and the Filings when read together
do not contain any untrue statement of a material fact and do not omit to state a material fact necessary to make the statements
herein as a whole not misleading.


 


		III.	TERMS
                                         OF SUBSCRIPTION



 


3.1              
There is no minimum aggregate Offering size.


 






     


     


    

 


3.2              
The Company will conduct the Closing at the time and place of its choice (the “Closing Date”) whereupon:


 


(a)               
the Subscriber shall deliver to the Company, if not previously delivered: (i) this duly completed and executed Agreement
and the applicable Accredited Investor Certificate; and (ii) the Purchase Price payable for the Shares by wire transfer to
an account designated by the Company Counsel (collectively, the “Subscriber Deliverables”); and


 


(b)               
the Company will deliver to the Subscriber at or prior to the Closing Date (unless otherwise specified below):


 


		(i)	a
                                         certificate of good standing of the Company issued by the British Columbia Registrar
                                         of Companies dated no later than one (1) business day before the Closing Date;



		(ii)	an
                                         officer’s certificate of the Company, dated as of the Closing Date, as to: (I)
                                         the resolutions of the Board then in full force and effect authorizing the execution,
                                         delivery and performance of this Agreement to be executed by the Company and the transactions
                                         contemplated thereby; (II) the incumbency and signatures of those of its officers authorized
                                         to act with respect to this Agreement to be executed by such person; and (III) the full
                                         force and validity of each organizational document of the Company and copies thereof;



		(iii)	a
                                         closing certificate, dated as of the Closing Date and duly executed and delivered by
                                         the Chief Executive Officer or Chief Financial Officer of the Company, certifying for
                                         and on behalf of the Company and not in their personal capacities, to the best of the
                                         knowledge, information and belief of the persons so signing, after having made due enquiry,
                                         that: (I) the Company has complied in all material respects with all the covenants and
                                         satisfied all the terms and conditions of this Agreement on its part to be complied with
                                         and satisfied at or prior to the Closing Date and (II) the representations and warranties
                                         of the Company contained herein are true and correct in all respect as at the Closing
                                         Date;



		(iv)	evidence
                                         of receipt of the TSX Approval;



		(v)	a
                                         copy of this Agreement duly executed by the Company;



		(vi)	an
                                         opinion of Company Counsel in a form acceptable to the Subscriber in respect of the Shares;
                                         and



		(vii)	within
                                         two (2) business days after the Closing Date, a certificate registered in the name of
                                         the Subscriber (or as directed by it) duly executed and delivered by the Company, representing
                                         the Shares purchased hereunder free and clear of all liens, security interests, claims
                                         and encumbrances (and in this regard the Subscriber hereby authorizes and directs the
                                         Company to deliver the certificate representing the Shares purchased by the Subscriber
                                         pursuant to this Agreement to the address indicated on the signature page hereto) (items
                                         (i) through (vii) collectively, the “Company Deliverables”).



 






     


     


    

  





		IV.	CONDITIONS TO CLOSING



 


4.1                    
The Subscriber’s obligation to purchase the Shares on the Closing Date is subject to the fulfillment of certain conditions,
which conditions may be waived at the option of the Subscriber to the extent permitted by law, as follows:


 


(a)               
Representations and Warranties Correct. The representations and warranties made by the Company in Article II hereof
shall be true and correct in all material respects as at the Closing Date.


 


(b)               
Covenants. All covenants, agreements and conditions contained in this Agreement to be performed by the Company on
or prior to the Closing Date shall have been performed or complied with in all material respects.


 


(c)               
No Legal Order Pending. There shall not then be in effect any legal or other order enjoining or restraining the
transactions contemplated by this Agreement.


 


(d)               
No Law Prohibiting or Restricting Such Sale. There shall not be in effect any law, rule or regulation prohibiting
or restricting the sale of the Shares (except as otherwise referred to in this Agreement) or requiring any consent or approval
of any person (including the TSX), which shall not have been obtained, to issue the Shares (except as referred to in this Agreement).


 


(e)               
TSX Listing. The TSX shall have conditionally approved the listing of the Shares, subject only to the satisfaction
by the Company of customary post-closing conditions imposed by the TSX in similar circumstances and without the requirement of
the Company to obtain shareholder approval for the Offering.


 


(f)                
Company Deliverables. The Company shall have delivered to the Subscriber all Company Deliverables.


 


(g)               
Opinion. The Subscriber shall have received an opinion from Company Counsel as to customary Canadian corporate and
securities matters in relation to the Shares in a form acceptable to the Subscriber, acting reasonably.


 


4.2                    
The Company’s obligation to sell the Shares on the Closing Date is subject to the fulfillment of certain conditions,
which conditions may be waived at the option of the Company to the extent permitted by law, as follows:


 


(a)               
Representations and Warranties Correct. The representations and warranties made by the Subscriber in Article I
hereof shall be true and correct in all material respects.


 


(b)               
Payment of Purchase Price. The Subscriber shall have delivered to the Company the Purchase Price for the Shares
purchased by it pursuant to Section 3.2(a).


 


(c)               
No Legal Order Pending. There shall not then be in effect any legal or other order enjoining or restraining the
transactions contemplated by this Agreement.


 


(d)               
No Law Prohibiting or Restricting Such Sale. There shall not be in effect any law, rule or regulation prohibiting
or restricting the sale of the Shares or requiring any consent or approval of any person, which shall not have been obtained,
to issue the Shares (except as otherwise provided in this Agreement).


 


(e)               
TSX Listing. The TSX shall have conditionally approved the listing of the Shares subject only to the satisfaction
by the Company of customary post-closing conditions imposed by the TSX in similar circumstances, and without the requirement of
the Company to obtain shareholder approval for the Offering.


 


(f)                
Subscriber Deliverables. The Subscriber shall have delivered to the Company all Subscriber Deliverables.


 






     


     


    

 





		V.	COVENANTS



 


5.1
       US Registration. The Company agrees to file with the U. S. Securities and Exchange
Commission (the “Commission”) a registration statement (a “Registration Statement”) on Form
S-1, or any other form for which the Company then qualifies or which counsel for the Company shall deem appropriate and which
form shall be available for the resale by the holders of all of the Shares issued pursuant to this Offering (“Registrable
Securities”), and the Company shall (a) use its commercially reasonable efforts to make the initial filing of the Registration
Statement no later than July 31, 2017, (b) use its commercially reasonable efforts to cause such Registration Statement to be
declared effective no later than December 31, 2017; and (c) use its commercially reasonable efforts to keep such Registration
Statement effective for a period of 2 years or for such shorter period ending on the earlier to occur of (i) the sale of all Registrable
Securities and (ii) the availability of Rule 144 for the Holder to sell all of the Registrable Securities without volume limitations
within a 90 day period (the “Effectiveness Period”); provided, however, that: 


 


		(a)	the
                                         Company shall not be obliged to effect a registration in accordance with the foregoing
                                         if Board determines in its good faith judgment that either (i) the effect of filing,
                                         amending or making effective a Registration Statement in accordance with the foregoing
                                         would materially adversely affect the Company including materially adversely affecting
                                         the ability of the Company to consummate a material financing, acquisition, corporate
                                         reorganization, merger or other material transaction involving the Company being considered
                                         at the time; or (ii) there exists at the time material non-public information relating
                                         to the Company the disclosure of which the Company believes would be detrimental to the
                                         Company and the Company has bona fide business purposes for preserving such information
                                         as confidential (a “Valid Business Reason”), provided that in either
                                         case the Company’s obligations under this Section 5.1 will be deferred for a period
                                         of not more than 90 days and that provided that the Company may not defer its obligations
                                         under Section 5.1 for a period of more than 120 days. The Company will give written notice
                                         of the Board’s determination to postpone filing and of the fact that the Valid
                                         Business Reason for such postponement no longer exists, in each case, promptly after
                                         the occurrence thereof; 



 


		(b)	the
                                         Company shall not be obligated to effect any such registration, qualification or compliance
                                         pursuant to this Section, or keep such registration effective pursuant to the terms hereunder,
                                         in any particular jurisdiction in which the Company would be required to qualify to do
                                         business as a foreign corporation or as a dealer in securities under the securities laws
                                         of such jurisdiction or to execute a general consent to service of process in effecting
                                         such registration, qualification or compliance, in each case where it has not already
                                         done so; and



 


		(c)	in the
                                         event that the Commission should limit the number of Registrable Securities that may
                                         be sold pursuant to the Registration Statement, the Company may remove from the Registration
                                         Statement such number of Registrable Securities as specified by the Commission (the “Cut
                                         Back Shares”) on behalf of all of the holders of Registrable Securities on
                                         a pro rata basis. In such event, the Company shall give the holders of Registrable Securities
                                         prompt notice of the number of Registrable Securities excluded therefrom.



 






     


     


    

  


5.2                    
Canadian Qualification Upon Becoming a Control Person. In the event the Subscriber shall become a “control
person” as such term is defined in the Securities Act (Ontario) for reasons other than having acquired voting rights
(within such meaning of the definition of “control person”) with respect to Common Shares other than the Shares acquired
under this Agreement, the Subscriber may, by written notice (the “Demand Notice”), require the Company to prepare
and file the necessary offering documents with one or more Canadian securities regulatory authorities or otherwise to qualify
the Registrable Securities for distribution in one or more Canadian reporting jurisdictions (a “Demand Registration”),
and the Company will otherwise take or cause to be taken all actions as may be necessary or desirable, in order to effect a public
offering of Registrable Shares by the Subscriber (a “Secondary Offering”). The Demand Notice shall state: (a)
the number of Registrable Securities the Subscriber wishes to sell in the Secondary Offering; (b) describe the nature or methods
of the proposed distribution thereof; and (c) specify the Canadian reporting jurisdictions in which such distribution shall be
made, provided that the Company is, on the date of giving of the Demand Notice, a reporting issuer in each such Canadian reporting
jurisdiction. The Subscriber shall send the Demand Notice to the Company. The Company shall not be obliged to effect a Demand
Registration in the event the Board determines in its good faith judgment that there exists a Valid Reason to not effect a Demand
Registration, provided that the Company’s obligations under this Section 5.2 will be deferred for a period of not more than
90 days from the date of receipt of the Demand Notice, provided that the Company may not defer its obligations under this Section
5.2 for a period of more than 120 days in any 12 consecutive months. The Company will give written notice of the Board’s
determination to postpone filing and of the fact that the Valid Business Reason for such postponement no longer exists, in each
case, promptly after the occurrence thereof. If the Company postpones the filing of a prospectus pursuant to this Section 5.2
and if the Subscriber that initiated the Demand Registration, at any time prior to receiving the Company’s written notice
that the Valid Business Reason for such postponement no longer exists, advises the Company in writing that it has determined to
withdraw such request for a Demand Registration, then such Demand Registration and the request therefor will be deemed to be withdrawn
and such request will be deemed not to have been given for purposes of determining whether the Subscriber exercised its right
to a Demand Registration pursuant to this Section 5.2, and the reasonable fees, expenses and disbursements of legal counsel to
the Subscriber incurred up to the date of withdrawal that would have been considered distribution expenses had such Demand Registration
been completed, shall be paid by the Company.


 


5.3                    
At any time, the Subscriber shall be entitled, upon notice in writing to the Company, to withdraw such Demand Notice made
pursuant to Section 5.2; provided, however, that the Subscriber shall pay all of the out of pocket expenses reasonably
incurred by the Company in connection with the proposed Secondary Offering. Notwithstanding the foregoing, if and only if, the
Subscriber withdraws the Demand Notice after having learned of a material adverse change in the condition, business or business
prospects of the Company, then the Subscriber will not be required to pay any such expenses or forfeit the right to one Demand
Registration.


 


5.4                    
In connection with a Secondary Offering, all distribution expenses shall be borne by the Subscriber and the Company in
proportion to the amount the gross proceeds received by the Subscriber and the Company bear to the total gross proceeds of the
Secondary Offering, provided that the Company shall not be responsible for the fees and disbursements of any legal counsel to
the Subscriber. If the Company is participating in the Demand Registration then the Company shall be responsible for all fees
and disbursements of legal counsel to the Company otherwise the Subscriber shall pay the fees and disbursements of legal counsel
to the Company proportionately based on the gross proceeds received by the Subscriber.


 






     


     


    

  


5.5                    
The Company shall not be obliged to effect more than three (3) Demand Registrations in any twelve (12) month period pursuant
to this Article V. The Subscriber shall not be permitted to exercise its Demand Registration rights pursuant to this Article V
prior to one hundred and eighty (180) days following the date of this Agreement and in any event more than once in any one hundred
and eighty (180) day period.


 


5.6                    
Following the Closing Date, so long as the Subscriber owns at least 4% of shares outstanding (subject to adjustment in
the event of any share split, consolidation, share dividend or the like), the Subscriber shall also have unlimited registration
rights relating to the inclusion of their Shares in any prospectus filed by the Company in one or more of the Canadian reporting
jurisdictions (a “Primary Offering”). At least twenty (20) days prior to the initial filing of a preliminary
prospectus for a Primary Offering, the Company will give written notice to the Subscriber of its intention to do so. Upon the
written request of the Subscriber given within ten (10) days after the Company provides such notice (which request will state
the number of Shares that is proposed to be included in such preliminary prospectus by the Subscriber (the “Piggy Back
Shares”), the Company will cause all such Piggy Back Shares to be qualified for sale under the preliminary prospectus
for a Primary Offering (a “Piggy Back Registration”); provided that the Company will have the right to postpone
or withdraw any Piggy Back Registration initiated by the Company prior to a receipt being issued for a preliminary prospectus
pursuant to this Section 5.6 without obligation to the Subscriber. If the Company withdraws any registration initiated by it,
for whatever reason, the Subscriber may initiate a Demand Registration, subject to, and in accordance with, the provisions of
Article V hereof.


 


5.7                    
The Company will pay all distribution expenses in connection with each Piggy Back Registration and the Subscriber will
pay all selling expenses of the Subscriber, in proportion to the gross proceeds received by the Subscriber from any Piggy Back
Registration.


 


5.8                    
Following the Closing Date, so long as the Subscriber owns at least 4% of shares outstanding (subject to adjustment in
the event of any share split, consolidation, share dividend on the like), in the event the Company wishes to complete a private
or public bona fide equity financing (an “Equity Financing”), the Company shall provide the Subscriber
with reasonable notice of and the opportunity to participate in such Equity Financing so as to maintain its then pro rata
voting interest in the Company; provided, however, that in no event shall this Section 5.8: (i) permit the Subscriber to acquire
securities which represent, together with the securities owned or controlled by the Subscriber immediately prior to the Equity
Financing, more than 19.9% of the outstanding voting securities of the Company upon completion of the Equity Financing; or (ii)
permit the Subscriber to acquire securities to the extent that the TSX would require the Company to seek and obtain security holder
approval as contemplated by Section 604 of the TSX Company Manual for the Equity Financing (and, absent such level of Subscriber
participation, security holder approval would not be required).


 


		VI.	Trading
                                         in COMPANY Securities



 


6.1                    
The Subscriber covenants and agrees that it will not purchase, sell, short, or engage in any securities transactions relating
to the Shares whatsoever (or advise any others to do so) while in possession of material non-public information regarding the
Company, including that it is contemplating the Offering.


 


		VII.	SURVIVAL



 


7.1                    
The representations and warranties contained in this Agreement and in each applicable Accredited Investor Certificate attached
hereto shall survive for a period of two (2) years after the Closing Date and continue in full force and effect and be binding
upon the Company and the Subscriber, notwithstanding the completion of the purchase of the Shares by the Subscriber pursuant hereto,
or the subsequent disposition of the Shares by the Subscriber. For greater certainty, all covenants under this Agreement shall
survive the execution and delivery of this Agreement and the Closing indefinitely.


 






     


     


    

  


		VIII.	MISCELLANEOUS



 


8.1                    
Any notice or other communication given hereunder shall be deemed sufficient if in writing and sent by registered or certified
mail, return receipt requested, or delivered by hand against written receipt therefor, addressed as follows:


 


if
to the Company, to it at:


 


Fennec Pharmaceuticals Inc.

PO Box 13628


68 TW Alexander Drive


Research Triangle Park,
NC 27709


Attention:
Rosty Raykov, President and Chief Executive Officer


 


if
to the Subscriber, to the Subscriber’s address indicated on the signature page of this Agreement.


 


Notices shall
be deemed to have been given or delivered on the date of mailing, except notices of change of address, which shall be deemed to
have been given or delivered when received.


 


8.2                    
Except as otherwise provided herein, this Agreement shall not be changed, modified or amended except in writing signed
by the parties to be charged, and this Agreement may not be discharged except by performance in accordance with its terms or in
writing signed by the party to be charged.


 


8.3                    
This Agreement shall be binding upon and inure to the benefit of the parties hereto and to their respective heirs, legal
representatives, successors and assigns. This Agreement, together with the schedules hereto, sets forth the entire agreement and
understanding between the parties as to the subject matter hereof and merges and supersedes all prior discussions, agreements
and understandings of any and every nature among them.


 


8.4                    
Upon the execution and delivery of this Agreement by the Subscriber, this Agreement shall become a binding obligation of
the Subscriber with respect to the purchase of Shares as herein provided, subject, however, to the right hereby reserved by the
Company to enter into the same agreements with other purchasers and/or and delete other persons as purchasers.


 


8.5                    
All questions concerning the construction, validity, enforcement and interpretation of this Agreement shall be governed
by and construed and enforced in accordance with the internal laws of the Province of British Columbia, without regard to the
principles of conflicts of law thereof. Each party hereby irrevocably waives personal service of process and consents to process
being served in any such suit, action or proceeding by mailing a copy thereof via registered or certified mail or overnight delivery
(with evidence of delivery) to such party at the address in effect for notices to it under this Agreement and agrees that such
service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to
limit in any way any right to serve process in any other manner permitted by law. The parties hereby waive all rights to a trial
by jury. If either party shall commence an action or proceeding to enforce any provisions of this Agreement, then the prevailing
party in such action or proceeding shall be reimbursed by the other party for its reasonable attorneys’ fees and other costs
and expenses incurred with the investigation, preparation and prosecution of such action or proceeding.


 






     


     


    

  


8.6                    
The holding of any provision of this Agreement to be invalid or unenforceable by a court of competent jurisdiction shall
not affect any other provision of this Agreement, which shall remain in full force and effect. If any provision of this Agreement
shall be declared by a court of competent jurisdiction to be invalid, illegal or incapable of being enforced in whole or in part,
such provision shall be interpreted so as to remain enforceable to the maximum extent permissible consistent with applicable law
and the remaining conditions and provisions or portions thereof shall nevertheless remain in full force and effect and enforceable
to the extent they are valid, legal and enforceable, and no provisions shall be deemed dependent upon any other covenant or provision
unless so expressed herein.


 


8.7                    
It is agreed that a waiver by either party of a breach of any provision of this Agreement shall not operate, or be construed,
as a waiver of any subsequent or other breach by that same party.


 


8.8                    
The parties agree to execute and deliver all such further documents, agreements and instruments and take such other and
further action as may be necessary or appropriate to carry out the purposes and intent of this Agreement.


 


8.9                    
This Agreement may be executed in two or more counterparts, including via facsimile or PDF, each of which shall be deemed
an original, but all of which shall together constitute one and the same instrument.


 


8.10                
Nothing in this Agreement shall create or be deemed to create any rights in any person or entity not a party to this Agreement.
The Subscriber hereby acknowledges and agrees that it shall bear all costs and expenses incurred by it (including any fees and
disbursements of any special counsel retained by it) relating to the sale of the Shares to the Subscriber.


 


		IX.	CONFIDENTIAL
                                         INVESTOR QUESTIONNAIRE



 


9.1                    
The Subscriber represents that it is an “accredited investor” within the meaning of Rule 501(a) of Regulation
D under the Act because it comes within any of the following categories at each time of the sale of the Shares to the Subscriber
(please initial beside the categories below applicable to the Subscriber). The undersigned agrees to furnish any additional information
which the Company deems necessary in order to verify the answers set forth below:


 


_____any
bank as defined in Section 3(a)(2) of the Securities Act, or any savings and loan association or other institution as defined
in Section 3(a)(5)(A) of such Act whether acting in its individual or fiduciary capacity, any broker or dealer registered pursuant
to Section 15 of the United States Securities Exchange Act of 1934, as amended, any insurance company as defined in Section 2(a)(13)
of the Securities Act, any investment company registered under the U.S. Investment Company Act of 1940 or a business development
company as defined in Section 2(a)(48) of the U.S. Investment Company Act of 1940, any small business investment company licensed
by the U.S. Small Business Administration under Section 301(c) or (d) of the U.S. Small Business Investment Act of 1958, any plan
established and maintained by a state, its political subdivisions, or any agency or instrumentality of a state or its political
subdivisions for the benefit of its employees, if such plan has total assets in excess of $5,000,000, any employee benefit plan
within the meaning of the U.S. Employee Retirement Income Security Act of 1974, if the investment decision is made by a plan fiduciary,
as defined in Section 3(21) of the U.S. Employee Retirement Income Security Act of 1974, which is either a bank, savings and loan
association, insurance company, or registered investment adviser, or if the employee benefit plan has total assets in excess of
$5,000,000 or, if a self-directed plan, with investment decisions made solely by persons that are accredited investors;


 


_____any
private business development company as defined in Section 202(a)(22) of the U.S. Investment Advisers Act of 1940;


 


_____any
organization described in Section 501(c)(3) of the U.S. Internal Revenue Code, corporation, Massachusetts or similar business
trust, or partnership, not formed for the specific purpose of acquiring the securities offered, with total assets in excess of
$5,000,000;


 


_____any
director, executive officer, or general partner of the issuer of the securities being offered or sold, or any director, executive
officer, or general partner of a general partner of that issuer;


 


_____any
natural person whose individual net worth, or joint net worth with that person's spouse, at the time of his purchase exceeds $1,000,000
(excluding such person’s primary residence) ;


 


_____any
natural person who had an individual income in excess of $200,000 in each of the two most recent years or joint income with that
person's spouse in excess of $300,000 in each of those years and has a reasonable expectation of reaching the same income level
in the current year;


 


_____any
trust, with total assets in excess of $5,000,000, not formed for the specific purpose of acquiring the securities offered, whose
purchase is directed by a sophisticated person as described in Rule 506(b)(2)(ii) of Regulation D under the Securities Act; or


 


_____any
entity in which all of the equity owners are accredited investors.


 


The undersigned
agrees that the undersigned will notify the Company at any time on or prior to either Closing, in the event that the representations
and warranties in this Agreement shall cease to be true, accurate and complete.









     


     


    

 


9.2       
SUITABILITY (please answer each question)


 





		(a)	For
                                         an individual Subscriber, please describe your current employment, including the company
                                         by which you are employed and its principal business:
	 	 	 
	 	 	 
	 	 	 
	 	 	 



 





		(b)	For
                                         an individual Subscriber, please describe any college or graduate degrees held by you:
	 	 	 
	 	 	 
	 	 	 
	 	 	 



  





		(c)	For all Subscribers, please
list types of prior investments:
	 	 	 
	 	 	 
	 	 	 
	 	 	 



  


 





		(d)	For
                                         all Subscribers, please state whether you have you participated in other private placements
                                         before:



 


	YES	 	 	NO	 	 


 






     


     


    

 


		(e)	If your
                                         answer to question (d) above was “YES”, please indicate frequency of such
                                         prior participation in private placements of:



  





	 	Public

Companies
	 	Private

Companies
	 	Public
        or Private

        Biotechnology Companies

        

	Frequently	 	 	 	 	 
	Occasionally	 	 	 	 	 
	Never	 	 	 	 	 


 








		(f)	For
                                         individual Subscribers, do you expect your current level of income to significantly decrease
                                         in the foreseeable future:



 


	YES	 	 	NO	 	 


 


		(g)	For
                                         trust, corporate, partnership and other institutional Subscribers, do you expect your
                                         total assets to significantly decrease in the foreseeable future:



 


	YES	 	 	NO	 	 


 


		(h)	For
                                         all Subscribers, do you have any other investments or contingent liabilities which you
                                         reasonably anticipate could cause you to need sudden cash requirements in excess of cash
                                         readily available to you:



 


	YES	 	 	NO	 	 


 


		(i)	For
                                         all Subscribers, are you familiar with the risk aspects and the non-liquidity of investments
                                         such as the securities for which you seek to purchase?



 


	YES	 	 	NO	 	 


 


		(j)	For
                                         all Subscribers, do you understand that there is no guarantee of financial return on
                                         this investment and that you run the risk of losing your entire investment?



 


	YES	 	 	NO	 	 


 


9.3       
MANNER IN WHICH TITLE IS TO BE HELD. (circle one)


 



		(a)	Individual Ownership



		(b)	Community Property



		(c)	Joint Tenant with Right of
Survivorship (both parties must sign)



		(d)	Partnership*



		(e)	Tenants in Common



		(f)	Company*



		(g)	Trust*



		(h)	Other



 


*If
Shares are being purchased for by an entity, a Certificate of Signatory must also be completed.


 






     


     


    

 


9.4       
FINRA AFFILIATION.


 


Are you affiliated
or associated with an FINRA member firm (please check one):


 


	YES	 	 	NO	 	 


 


If Yes, please
describe:





 





 



 





 



 





 



 





*If Subscriber
is a Registered Representative with an FINRA member firm, have the following acknowledgment signed by the appropriate party:


 


The undersigned
FINRA member firm acknowledges receipt of the notice required by the Rules of Conduct.


 





	 	 
	Name of FINRA Member Firm	 
	 	 	 
	By:
    	 	 
	 	Authorized
    Officer	 
	 	 	 
	Date:
    	 	 







 


9.5       
The undersigned is informed of the significance to the Company of the foregoing representations and answers contained in
the Confidential Investor Questionnaire contained in this Article IX and such answers have been provided under the assumption
that the Company will rely on them.


 


 


[REMAINDER OF
PAGE INTENTIONALLY LEFT BLANK]


 


 




     


     


    

 





	Name
    of Subscriber: 	 	 
	 	 	 



 


	 	 
	 	 
	Signature	 
	 	 
	 	 
	Name
    Typed or Printed	 
	 	 
	 	 
	Address	 
	 	 
	 	 
	Country,
    City, State and Zip Code	 
	 	 
	 	 
	Telephone	 
	 	 
	 	 
	Facsimile	 
	 	 
	 	 
	Tax
    ID # or Social Security # 	 
	 	 
	Name
    in which Shares should be issued:	 	 
	 	 
	 	 
	Dated:
    __________________ _____, 2017	 







 





 







     


     


    

 


This Agreement
is agreed to and accepted as of __________________ _____, 2017.


 


 





	 	FENNEC PHARMACEUTICALS Inc.
	 	 	 	 
	 	 	 	 
	 	By:		 
	 	Name:	 	 
	 	Title:	 	 







 


 







     


     


    

 


SCHEDULE
“A”


SUMMARY
OF OFFERING TERMS


 


C
o n f i d e n t i a l


 


This
confidential term sheet summarizes the principal terms of a proposed equity financing by Fennec Pharmaceuticals Inc. Except as
described below next to the heading, Confidentiality/No Trading (which is intended to binding on proposed investors), this term
sheet is for discussion purposes only; there is no obligation on the part of any negotiating party until definitive transaction
documents are signed. 


 


New Issue





 


TERM SHEET


Private
Placement of COMMON Shares


 


	Issuer:	Fennec
    Pharmaceuticals Inc. (the “Company”).
	 	 
	Offering:	Private
    placement of up to 2,000,000 common shares in the capital of the Company (the “Shares”)
	 	 
	Offering
    Size:	Up
    to USD$8,000,000
	 	 
	Issue
    Price:	USD$4.00
    per Share.  
	 	 
	Use of
    Proceeds:	The
    Company intends to use the net proceeds of the Offering for STS development and general corporate purposes. 
	 	 
	Hold
    Period:	No
    prospectus or offering memorandum will be prepared. The Shares will be subject to certain hold periods in the United States
    pursuant to US securities laws and a hold period of four months and a day following the Closing Date pursuant to Canadian
    securities laws.
	 	 
	Listing:	The
    Company’s common shares are listed on the TSX (FRX) and, in the United States, are quoted on OTC (FENCF).  The
    Company will obtain the necessary approvals to list the Shares issued under this Offering on the TSX. 
	 	 
	Closing
    Date:	June
    8, 2017 (the “Closing Date”). 
	 	 
	Confidentiality/No
    Trading:	Investor
    understands and agrees that this Term Sheet, and the information set forth herein, constitutes confidential information and,
    accordingly, each investor agrees not to purchase, sell, short or engage in any securities transactions relating to the Company’s
    securities whatsoever (or advise others to do so) in violation of applicable securities laws. 



 


 



     


     


    

 





SCHEDULE
“B”


REGULATION
“S” RESALE REPRESENTATION LETTER


 


 


Fennec Pharmaceuticals Inc.

PO Box 13628


68 TW Alexander Drive


Research Triangle Park, NC 27709


Attention: President
and Chief Executive Officer


 


To Whom It
May Concern:


 


The undersigned
(A) acknowledges that the sale of the securities of Fennec Pharmaceuticals Inc. (the “Company”) to which
this declaration relates is being made in reliance on Rule 904 of Regulation S under the United States Securities Act
of 1933, as amended (the “Act”) and (B) certifies that: (1) the offer of such securities was not
made to a person in the United States and either (a) at the time the buy order was originated, the buyer was outside the
United States, or the seller and any person acting on its behalf reasonably believes that the buyer was outside the United States
or (b) the transaction was executed on or through the facilities of the Toronto Stock Exchange and neither the seller nor
any person acting on its behalf knows that the transaction has been prearranged with a buyer in the United States; (2) neither
the seller (or its affiliates) nor any person acting on its behalf engaged in any “directed selling efforts” in the
United States in connection with the offer and sale of such securities; (3) the sale is bona fide and not for the purpose of “washing
off” the resale restrictions imposed because the securities are “restricted securities” (as such term is defined
in Rule 144(a)(3) under the Act); (4) the seller does not have a short position in the securities sold and does not intend to
replace the securities sold in reliance on Rule 904 with fungible unrestricted securities; (5) the contemplated sale is not a
transaction, or part of a series of transactions which, although in technical compliance with Regulation S, is part of a plan
or scheme to evade the registration provisions of the Act; and (6) the undersigned is not an “affiliate” (as defined
in Rule 405 under the Act) of the Company. Terms used herein have the meanings given to them by Regulation S.


 


 


	 	 
	Name:
    	 
	Title:
    	 
	Date:
    	 







 





 




     


     


    

 


CERTIFICATE
OF SUBSEQUENT SALE


 


[Name and Address
of Transfer Agent]


 


RE:Sale
of Shares of Common Stock of Fennec Pharmaceuticals Inc. (the “Company”)


 


Dear Sir/Madam:


 


The
undersigned hereby certifies, in connection with the sale of Common Shares of the Company, that the undersigned has sold the shares
in compliance with all securities laws applicable to the undersigned.


 








	Selling
    Stockholder (the beneficial owner): 	 	 
	 	 	 
	Record Holder
    (e.g., if held in name of nominee): 	 	 
	 	 	 
	Restricted
    Stock Certificate No.(s): 	 	 
	 	 	 
	Number of Shares
    Sold: 	 	 
	 	 	 
	Date of Sale: 	 	 










 


 





		 	Very truly yours,	 
	 	 	 	 	 
	Dated: 	 	 	By:  	 	 
	 	 	Print Name: 	 	 
		 	Title: 	 	 
	 	 	 	 	 
		 	 	 	 







 


 








	cc:	Fennec
    Pharmaceuticals Inc.
	 	PO
    Box 13628
	 	68 TW Alexander
    Drive
	 	Research Triangle
    Park, NC 27709
	 	Attention: President and Chief Executive Officer







 







     


     


    

 


SCHEDULE
“C”


 


ACCREDITED
INVESTOR CERTIFICATE CANADA – NATIONAL INSTRUMENT 45-106


 


		TO:	FENNEC
                                         PHARMACEUTICALS INC.



 


In
connection with the subscription for Shares of Fennec Pharmaceuticals Inc. (the “Company”), the undersigned
(the “Subscriber”) hereby represents and warrants that the Subscriber is an “accredited investor”
as defined in National Instrument 45-106 – Prospectus Exemptions by virtue of being (check one):


 


	  ̈	(a)                
     	(i)
        except in Ontario, a Canadian financial institution or a bank listed in Schedule III to the Bank Act (Canada),

        (ii)
        in Ontario, a bank listed in Schedule I, II or III to the Bank Act (Canada).

        (iii)
        in Ontario, an association to which the Cooperative Credit Associations Act (Canada) applies or a central cooperative
        credit society for which an order has been made under subsection 473(1) of that Act.

        (iv)
        in Ontario, a loan corporation, trust company, trust corporation, insurance company, treasury branch, credit union, caisse
        populaire, financial services cooperative or credit union league or federation that is authorized by a statute of Canada
        or Ontario to carry on business in Canada or Ontario, as the case may be.

	  ̈	(b)               
     	the
    Business Development Bank of Canada,
	  ̈	(c)                
     	a
    subsidiary of any person or company referred to in clause (a) or (b), if the person or company owns all of the voting securities
    of the subsidiary, except the voting securities required by law to be owned by directors of that subsidiary,
	  ̈	(d)               
     	a
    person or company registered under the securities legislation of a province or territory of Canada as an adviser or dealer,
    except as otherwise prescribed by regulation,
	  ̈	(e)                
     	an
    individual registered under the securities legislation of a jurisdiction of Canada as a representative of a person referred
    to in paragraph (d),
	  ̈	(f)                 
     	an
    individual formerly registered under the securities legislation of a jurisdiction of Canada, other than an individual formerly
    registered solely as a representative of a limited market dealer under one or both of the Securities Act (Ontario)
    or the Securities Act (Newfoundland and Labrador),
	  ̈	(g)               
     	the
    Government of Canada, the government of a province or territory of Canada, or any Crown corporation, agency or wholly owned
    entity of the Government of Canada or of the government of a province or territory of Canada,
	  ̈	(h)               
     	a
    municipality, public board or commission in Canada and a metropolitan community, school board, the Comité de gestion
    de la taxe scolaire de l’Île de Montréal or an intermunicipal management board in Québec,
	  ̈	(i)                 
     	any
    national, federal, state, provincial, territorial or municipal government of or in any foreign jurisdiction, or any agency
    of that government,
	  ̈	(j)                 
     	a
    pension fund that is regulated by either the Office of the Superintendent of Financial Institutions (Canada) or a pension
    commission or similar regulatory authority of a province or territory of Canada,
	  ̈	(k)               
     	an
    individual who, either alone or with a spouse, beneficially owns financial assets having an aggregate realizable value that,
    before taxes but net of any related liabilities, exceeds $1,000,000, and the undersigned has completed and signed the enclosed
    Form 45-106F9,
	  ̈	(l)                 
     	an
    individual who beneficially owns financial assets having an aggregate realizable value that, before taxes but net of any related
    liabilities, exceeds $5,000,000,
	  ̈	(m)              
     	an
    individual whose net income before taxes exceeded $200,000 in each of the 2 most recent calendar years or whose net income
    before taxes combined with that of a spouse exceeded $300,000 in each of the 2 most recent calendar years and who, in either
    case, reasonably expects to exceed that net income level in the current calendar year, and the undersigned has completed
    and signed the enclosed Form 45-106F9,



 






     


     


    

  


	  ̈	(n)               
     	an
    individual who, either alone or with a spouse, has net assets of at least $5,000,000, and the undersigned has completed
    and signed the enclosed Form 45-106F9,
	  ̈	(o)               
     	a
    person, other than an individual or investment fund, that has net assets of at least $5,000,000 as shown on its most recently
    prepared financial statements, and that has not been created or used solely to purchase or hold securities as an accredited
    investor,
	  ̈	(p)               
     	an
        investment fund that distributes or has distributed its securities only to:

        (i)       a
        person that is or was an accredited investor at the time of the distribution,

        (ii)       a
        person that acquires or acquired securities in the circumstances referred to in sections 2.10 of National Instrument 45-106
        (“NI 45-106”) [Minimum amount investment], or 2.19 of NI 45-106 [Additional investment in investment
        funds], or

        (iii)       a
        person described in paragraph (i) or (ii) that acquires or acquired securities under section 2.18 of NI 45-106 [Investment
        fund reinvestment],

	  ̈	(q)               
     	an
    investment fund that distributes or has distributed securities under a prospectus in a jurisdiction of Canada for which the
    regulator or, in Québec, the securities regulatory authority, has issued a receipt,
	  ̈	(r)                 
     	a
    trust company or trust corporation registered or authorized to carry on business under the Trust and Loan Companies Act
    (Canada) or under comparable legislation in a jurisdiction of Canada or a foreign jurisdiction, acting on behalf of a
    fully managed account managed by the trust company or trust corporation, as the case may be,
	  ̈	(s)                
     	a
    person acting on behalf of a fully managed account managed by that person, if that person is registered or authorized to carry
    on business as an adviser or the equivalent under the securities legislation of a jurisdiction of Canada or a foreign jurisdiction,
	  ̈	(t)                 
     	a
    registered charity under the Income Tax Act (Canada) that, in regard to the trade, has obtained advice from an eligibility
    adviser or an adviser registered under the securities legislation of the jurisdiction of the registered charity to give advice
    on the securities being traded,
	  ̈	(u)               
     	an
    entity organized in a foreign jurisdiction that is analogous to the entity referred to in paragraph (a)-(d) or (j) in form
    and function,
	  ̈	(v)               
     	a
    person in respect of which all of the owners of interests, direct, indirect or beneficial, except the voting securities required
    by law to be owned by directors, are persons that are accredited investors,
	  ̈	(w)              
     	an
    investment fund that is advised by a person registered as an adviser or a person that is exempt from registration as an adviser,
	  ̈	(x)               
     	a
    person that is recognized or designated by the securities regulatory authority or, except in Ontario and Québec, the
    regulator as an accredited investor, or
	  ̈	(y)               
     	a
    trust established by an accredited investor for the benefit of the accredited investor’s family members of which a majority
    of the trustees are accredited investors and all of the beneficiaries are the accredited investor’s spouse, a former
    spouse of the accredited investor or a parent, grandparent, brother, sister, child or grandchild of that accredited investor,
    of that accredited investor’s spouse or of that accredited investor’s former spouse.


 


 


Dated this ____ day of _____________,
2017


 





	 	Signed:  	 	 
	 	Name:	 	 
	 	For:	 	 
	 	Title:	 	 




 


 




     


     


    

 


SCHEDULE
“D”


 


ACCREDITED
INVESTOR CERTIFICATE FOR RESIDENTS OF 


AN INTERNATIONAL
JURISDICTION


 


		TO:	FENNEC PHARMACEUTICALS
INC.



 


Any
capitalized terms not defined herein shall have the meaning set forth in the Subscription Agreement between the undersigned and
Fennec Pharmaceuticals Inc. dated on or about the date hereof.


 


In
connection with the subscription for Shares of Fennec Pharmaceuticals Inc. (the “Company”), the undersigned
(the “Subscriber”) hereby represents, warrants and covenants (on its own behalf or, if applicable, on behalf
of those for whom the Subscriber is contracting hereunder) and certifies to the Company and acknowledges that the Company is relying
thereon that:


 


General


 


		A.	The
                                         Subscriber is resident in an International Jurisdiction (as defined in the Subscription
                                         Agreement) or is subject to the laws of that International Jurisdiction;



 


		B.	The
                                         Subscriber complies with the requirements of all applicable securities laws in their
                                         International Jurisdiction and will provide such evidence of compliance with all such
                                         matters as the Company may request;



 


		C.	Upon
                                         execution of this Accredited Investor Certificate by the Subscriber, this Certificate
                                         shall be incorporated into and form a part of the Subscription Agreement;



 


		D.	The
                                         Subscriber is purchasing the Shares as principal for its own account and not for the
                                         benefit of any other person, for investment only, and will comply with all applicable
                                         securities laws and with the policies of the TSX concerning the purchase, the holding
                                         of and the resale restrictions on the securities; or is acting as agent for one or more
                                         disclosed purchasers, each disclosed purchaser is purchasing as principal for its own
                                         account and not for the benefit of any other person, for investment only, and not with
                                         a view to the resale or distribution of all or any of the Shares;



 


Prospectus Exemptions


 


		E.	The
                                         Subscriber is knowledgeable of securities legislation having application or jurisdiction
                                         over the Subscriber and the Offering (other than the laws of Canada and the U.S.) which
                                         would apply to this subscription; 



 


		F.	The
                                         Subscriber is purchasing the Shares pursuant to exemptions from any prospectus, registration
                                         or similar requirements under the laws of that International Jurisdiction or, if such
                                         is not applicable, the Subscriber is permitted to purchase the Shares, and the Company
                                         does not have any filing obligations in the International Jurisdiction; and 



 


		G.	No
                                         laws in the International Jurisdiction require the Company to make any filings or seek
                                         any approvals of any kind whatsoever from any regulatory authority of any kind whatsoever
                                         in the International Jurisdiction.



 




     


     


    

 





Dated this ____ day of _____________,
2017


 





	 	Signed:  	 	 
	 	Name:	 	 
	 	For:	 	 
	 	Title: