EX-10.1



 Exhibit 10.1 

TRANSITION, RETIREMENT AND RELEASE OF CLAIMS AGREEMENT 

This Transition, Retirement and Release of Claims Agreement (the “Agreement”) is made as of May 3, 2017 (the “Effective
Date”) between AVEO Pharmaceuticals (“AVEO” or the “Company”) and Keith Ehrlich (“Executive”) (together, the “Parties”). 

WHEREAS, Executive currently serves as Chief Financial Officer of the Company pursuant to an employment agreement dated April 21, 2015
(the “Employment Agreement”); 
 WHEREAS, in connection with Executive’s decision to retire, the Parties wish to
establish the terms for Executive’s orderly transition and resignation from the Company (as described below); and 
 WHEREAS, by
entering into this Agreement, Executive acknowledges and agrees that he is not entitled to any severance pay, benefits, equity rights or any other form of compensation or payment in respect of his separation from employment, including, without
limitation, pursuant to any other agreement, severance plan, program, policy or arrangement, except as specifically set forth herein. 

NOW, THEREFORE, in consideration of the mutual covenants and agreements contained herein, and for other good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the Parties hereby agree as follows: 
  

	1.	Transition Period and Retirement Date – 

 (a) In order to ensure an orderly
transition, Executive agrees to remain employed in his current position until June 30, 2017 (the “Retirement Date”). The period between the Effective Date and the Retirement Date is referred to in this Agreement as the
“Transition Period.” Subject to Section 1(b) below, Executive’s last day of employment shall be the Retirement Date. Executive shall continue to be employed and have the powers, duties and responsibilities customarily associated
with his current position as Chief Financial Officer from the Effective Date until the Retirement Date, unless modified by the Chief Executive Officer or the Board of Directors (the “Board”). Executive shall perform such transition duties
as may be reasonably requested by and at the direction of the Chief Executive Officer and/or the Board during the Transition Period. During the Transition Period, the Executive will continue to receive his base salary, less all applicable taxes and
withholdings, as well as customary benefits and the Executive’s outstanding equity awards shall continue to vest and become exercisable in accordance with the terms of the applicable award agreements. For the avoidance of doubt, vesting of all
equity awards shall end with the cessation of employment on the Retirement Date. 
 (b) Notwithstanding any of the foregoing, the Company
retains the right to immediately terminate Executive’s employment with or without “Cause” (as defined below) prior to the Retirement Date. In the event the Company terminates Executive’s employment without Cause prior to the
Retirement Date, Executive will continue to receive his base salary, less all applicable taxes and withholdings, as well as customary benefits and the Executive’s outstanding equity awards shall continue to vest and become 








	 	exercisable in accordance with the terms of the applicable award agreements, each through the Retirement Date, and Executive will remain eligible to receive the Severance Benefits described below, following his
execution and non-revocation of the Additional Release. In the event the Company terminates Executive’s employment for Cause or Executive resigns from employment prior to the Retirement Date (unless
otherwise agreed to by the Company in connection with such resignation), Executive will not be eligible to receive the Severance Benefits in whole or in part, nor will Executive receive any further salary payments, benefits, or other compensation
from the Company following the Executive’s separation from employment. For purposes of this Section 1(b), Cause means, in the good faith determination of the Board of Directors, the occurrence of any of the following events:
(i) conviction of, or plea of, nolo contendere with respect to any felony or a crime involving moral turpitude, (ii) commission of an act of personal dishonesty or breach of fiduciary duty involving personal profit in connection with the
Company, (iii) commission of an act, or failure to act, which is found to have involved willful misconduct or gross negligence on Executive’s part, in the conduct of his duties as an employee of the Company, (iv) willful and material
failure or refusal to perform services for the Company, (v) any failure to fulfill the terms and conditions under which Executive is employed by the Company, or (vi) willful and material failure or refusal to carry out a direct, lawful
written request of the Board or the Company’s Chief Executive Officer. 

  

	2.	Resignation from All Positions – Effective on the Retirement Date, Executive will be deemed to have resigned from any and all positions he holds with the Company including, but not limited to, his
position as a Chief Financial Officer and his designation as a Section 16 officer (as set forth in Rule 16a-1(f) under the Securities Exchange Act of 1934). Executive agrees to execute and deliver any
documents reasonably necessary to effectuate such resignations, and hereby irrevocably appoints the Company to be his attorney-in-fact to execute any documents and do
anything in his name to effect such resignations. A written notification signed by a director or duly authorized officer of the Company that any instrument, document or act falls within the authority conferred by this subsection will be conclusive
evidence that it does so. 

  

	3.	Severance Benefits – The Company shall provide Executive with the following consideration (collectively, the “Severance Benefits”), provided that Executive shall only receive the Severance
Benefits to the extent Executive (a) signs and returns this Agreement on or before May 3, 2017, (b) complies with the terms and conditions of this Agreement, (c) remains continuously employed by the Company for the duration of the
Transition Period, unless the Company terminates the Executive’s employment without Cause earlier, (d) signs and returns on, but not before, the Retirement Date, and does not revoke within the subsequent seven (7) day period the
Additional Release attached hereto as Attachment A (the “Additional Release”) and (e) provides any requested reasonable transition assistance during the three (3) month period immediately following the Retirement Date (the
“Immediate Post-Retirement Period”) (a, b, c, d and e of this paragraph, collectively, shall be referred to as the “Release Requirements”). Other than the Severance Benefits set forth below, Executive will not be eligible for,
nor shall he have a right to receive, any payments or benefits from the Company following the Retirement Date. 


  
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 (a) The Company will pay Executive $81,118.26, and further less all applicable taxes and
withholdings, as severance pay (an amount equivalent to three (3) months of Executive’s current base salary). This severance pay will be paid in a lump sum at the conclusion of the Immediate Post-Retirement Period. 

(b) Should Executive timely elect and be eligible to continue receiving group health insurance pursuant to the “COBRA” law, the
Company will, until the earlier of (x) the date that is three (3) months following the Retirement Date, and (y) the date on which Executive obtains alternative coverage (as applicable, the “COBRA Contribution Period”),
continue to pay the share of the premiums for such coverage to the same extent it was paying such premiums on Executive’s behalf immediately prior to the Retirement Date. The remaining balance of any premium costs during the COBRA Contribution
Period, and all premium costs thereafter, shall be paid by you on a monthly basis for as long as, and to the extent that, you remain eligible for COBRA continuation. You agree that, should you obtain alternative medical and/or dental insurance
coverage prior to the date that is three (3) months following the Retirement Date, you will so inform the Company in writing within five (5) business days of obtaining such coverage. 

(c) The exercise period for the vested portion of each unexercised time-based stock option award held by the Executive on the Retirement Date,
notwithstanding any contrary terms set forth in the stock option agreement evidencing such awards, is extended to December 31, 20I8. 
  

	4.	Release of Claims – In exchange for the consideration set forth in this Agreement, which Executive acknowledges he would not otherwise be entitled to receive, Executive hereby fully, forever,
irrevocably and unconditionally releases, remises and discharges the Company, its affiliates, subsidiaries, parent companies, predecessors, and successors, and all of their respective past and present officers, directors, stockholders, partners,
members, employees, agents, representatives, plan administrators, attorneys, insurers and fiduciaries (each in their individual and corporate capacities) (collectively, the “Released Parties”) from any and all claims, charges, complaints,
demands, actions, causes of action, suits, rights, debts, sums of money, costs, accounts, reckonings, covenants, contracts, agreements, promises, doings, omissions, damages, executions, obligations, liabilities, and expenses (including
attorneys’ fees and costs), of every kind and nature that Executive ever had or now has against any or all of the Released Parties, whether known or unknown, including, but not limited to, any and all claims arising out of or relating to
Executive’s employment with and/or separation from the Company, including, but not limited to, all claims under Title VII of the Civil Rights Act, the Americans With Disabilities Act, the Genetic Information Nondiscrimination Act, the Family
and Medical Leave Act, the Worker Adjustment and Retraining Notification Act, the Rehabilitation Act, Executive Order 11246, Executive Order 11141, the Fair Credit Reporting Act, and the Employee Retirement Income Security Act, all as amended; all
claims arising out of the Massachusetts Fair Employment Practices Act, Mass. Gen. Laws ch. 151B, § 1 et seq., the Massachusetts Wage Act, Mass. Gen. Laws ch. I49, § 148 et seq. (Massachusetts law regarding
payment of wages and overtime), the Massachusetts Civil Rights Act, Mass. Gen. Laws ch. 12, §§ 11H and 11I, the Massachusetts Equal Rights Act, Mass. Gen. Laws. ch. 93, § 102 and Mass. Gen. Laws ch. 214, § 1C, the



  
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	    	Massachusetts Labor and Industries Act, Mass. Gen. Laws ch. 149, § 1 et seq., Mass. Gen. Laws ch. 214, § 1B (Massachusetts right of privacy law), the Massachusetts Maternity Leave Act, Mass. Gen.
Laws ch. 149, § 105D, and the Massachusetts Small Necessities Leave Act, Mass. Gen. Laws ch. 149, § 52D, all as amended; all common law claims including, but not limited to, actions in defamation, intentional infliction of emotional
distress, misrepresentation, fraud, wrongful discharge, and breach of contract (including, without limitation, all claims arising out of or related to the Employment Agreement); all state and federal whistleblower claims to the maximum extent
permitted by law; and any claim or damage arising out of Executive’s employment with and/or separation from the Company (including a claim for retaliation) under any common law theory or any federal, state or local statute or ordinance not
expressly referenced above; provided, however, that nothing in this release of claims prevents Executive from filing a charge with, cooperating with, or participating in any investigation or proceeding before, the Equal Employment Opportunity
Commission or a state fair employment practices agency (except that Executive acknowledges that he may not recover any monetary benefits in connection with any such charge, investigation, or proceeding, and Executive further waives any rights or
claims to any payment, benefit, attorneys’ fees or other remedial relief in connection with any such charge, investigation or proceeding). This release also does not prevent Executive from reporting possible violations of federal securities
laws to government enforcement agencies without notice to the Company, or from receiving any applicable award for information provided to such government enforcement agencies. 


 

	5.	Continuing Obligations – Executive acknowledges and reaffirms his obligation, to the extent permitted by law and except as otherwise permitted by Section 8 below, to keep confidential and not to
use or disclose, during the Transition Period or thereafter, any and all non-public information concerning the Company that he acquires or acquired during the course of his employment with the Company,
including, but not limited to, any non- public information concerning the Company’s business affairs, business prospects, and financial condition. Executive further acknowledges his obligations set forth
in the Invention and Non-Disclosure Agreement, which survives his separation from employment with the Company. 

  

	6.	Return of Company Property – Executive agrees that he will, on the Retirement Date or earlier if requested by the Company, return to the Company, except as otherwise agreed by the Company, all keys,
files, records (and copies thereof), equipment (including, but not limited to, computer hardware, software and printers, wireless handheld devices, cellular phones, tablets, etc.), Company identification and any other Company-owned property in his
possession or control and that he will leave intact all electronic Company documents, including but not limited to those that he developed or helped to develop during his employment. Executive further agrees that he will, on the Retirement Date or
earlier if requested by the Company, cancel all accounts for his benefit, if any, in the Company’s name, including but not limited to, credit cards, telephone charge cards, cellular phone and/or wireless data accounts and computer accounts.



  
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	7.	Confidentiality – Executive understands and agrees that, to the extent permitted by law and except as otherwise permitted by Section 8 below, the terms and contents of this Agreement, and the
contents of the negotiations and discussions resulting in this Agreement, shall be maintained as confidential by Executive and his agents and representatives and shall not be disclosed except as otherwise agreed to in writing by the Company.


  

	8.	Scope of Disclosure Restrictions – Nothing in this Agreement prohibits Executive from communicating with government agencies about possible violations of federal, state, or local laws or otherwise
providing information to government agencies or participating in government agency investigations or proceedings. Executive is not required to notify the Company of any such communications; provided, however, that nothing herein authorizes the
disclosure of information Executive obtained through a communication that was subject to the attorney-client privilege. Further, notwithstanding Executive’s confidentiality and nondisclosure obligations, Executive is hereby advised as follows
pursuant to the Defend Trade Secrets Act: “An individual shall not be held criminally or civilly liable under any Federal or State trade secret law for the disclosure of a trade secret that (A) is made (i) in confidence to a Federal,
State, or local government official, either directly or indirectly, or to an attorney; and (ii) solely for the purpose of reporting or investigating a suspected violation of law; or (B) is made in a complaint or other document filed in a
lawsuit or other proceeding, if such filing is made under seal. An individual who files a lawsuit for retaliation by an employer for reporting a suspected violation of law may disclose the trade secret to the attorney of the individual and use the
trade secret information in the court proceeding, if the individual (A) files any document containing the trade secret under seal; and (B) does not disclose the trade secret, except pursuant to court order.” 


 

	9.	Cooperation – 

 (a) Executive agrees that, following the Retirement Date,
Executive will provide full cooperation to the Company, including but not limited to, assisting the Company with the transition of his job duties and answering questions relating to the Company’s financial affairs. Executive acknowledges and
agrees that the severance pay set forth in Section 3 shall constitute full consideration for such post-employment assistance. 
 (b)
Executive agrees that, to the extent permitted by law, he shall cooperate fully with the Company in the investigation, defense or prosecution of any claims or actions which already have been brought, are currently pending, or which may be brought in
the future against the Company by a third party or by or on behalf of the Company against any third party, whether before a state or federal court, any state or federal government agency, or a mediator or arbitrator. Executive’s full
cooperation in connection with such claims or actions shall include, but not be limited to, being available to meet with the Company’s counsel, at reasonable times and locations designated by the Company, to investigate or prepare the
Company’s claims or defenses, to prepare for trial or discovery or an administrative hearing, mediation, arbitration or other proceeding and to act as a witness when requested by the Company. Executive further agrees that, to the extent
permitted by law, Executive will notify the Company promptly in the event that he is served with a 

  
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	    	subpoena (other than a subpoena issued by a government agency), or in the event that Executive is asked to provide a third party (other than a government agency) with information concerning any actual or potential
complaint or claim against the Company. 

  

	10.	Response to Inquiries – In response to inquiries from any third party concerning Executive’s separation from employment with the Company, the Company will respond with Executive’s dates of
employment, position and confirm that Executive voluntarily retired from employment with the Company. 

  

	11.	Amendment and Waiver – This Agreement shall be binding upon the Parties and may not be modified in any manner, except by an instrument in writing of concurrent or subsequent date signed by duly
authorized representatives of the Parties. This Agreement is binding upon and shall inure to the benefit of the Parties and their respective agents, assigns, heirs, executors, successors and administrators. No delay or omission by the Company in
exercising any right under this Agreement shall operate as a waiver of that or any other right. A waiver or consent given by the Company on any one occasion shall be effective only in that instance and shall not be construed as a bar to or waiver of
any right on any other occasion. 

  

	12.	Validity – Should any provision of this Agreement be declared or be determined by any court of competent jurisdiction to be illegal or invalid, the validity of the remaining parts, terms or provisions
shall not be affected thereby and said illegal or invalid part, term or provision shall be deemed not to be a part of this Agreement. 

  

	13.	Nature of Agreement – Both Parties understand and agree that this Agreement is a transition and separation agreement and does not constitute an admission of liability or wrongdoing on the part of the
Company or Executive. 

  

	14.	Acknowledgments – Executive acknowledges that he has been given a reasonable amount of time to consider this Agreement and at least twenty-one (21) days to
consider the Additional Release, and that the Company is hereby advising him to consult with an attorney of his own choosing prior to signing this Agreement or the Additional Release. Executive further understands that he may revoke the Additional
Release for a period of seven (7) days after he signs it by notifying the Company in writing, and the Additional Release shall not be effective or enforceable until the expiration of this seven (7) day revocation period. Executive
understands and agrees that by entering into the Additional Release, he will be waiving any and all rights or claims he might have under the Age Discrimination in Employment Act, as amended by the Older Workers Benefit Protection Act, and that he
has received consideration beyond that to which he was previously entitled. 

  

	15.	Voluntary Assent – Executive affirms that no other promises or agreements of any kind have been made to or with Executive by any person or entity whatsoever to cause him to sign this Agreement, and
that he fully understands the meaning and intent of this Agreement. Executive further states and represents that he has carefully read this Agreement, understands the contents herein, freely and voluntarily assents to all of the terms and conditions
hereof, and signs his name of his own free act. 


  
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	16.	Applicable Law – This Agreement shall be interpreted and construed by the laws of the Commonwealth of Massachusetts, without regard to conflict of laws provisions. Executive hereby irrevocably submits
to and acknowledges and recognizes the jurisdiction of the courts of the Commonwealth of Massachusetts, or if appropriate, a federal court located in the Commonwealth of Massachusetts (which courts, for purposes of this Agreement, are the only
courts of competent jurisdiction), over any suit, action or other proceeding arising out of, under or in connection with this Agreement or the subject matter hereof. 


 

	17.	Entire Agreement – This Agreement contains and constitutes (together with the Additional Release at such time as it becomes effective and enforceable) the entire understanding and agreement between
the Parties hereto with respect to Executive’s transition and separation from the Company, severance benefits and the settlement of claims against the Company, and cancels all previous oral and written negotiations, agreements, commitments and
writings in connection therewith. 

  

	18.	Tax Acknowledgement – In connection with the Severance Benefits provided to Executive pursuant to this Agreement, the Company shall withhold and remit to the tax authorities the amounts required under
applicable law, and Executive shall be responsible for all applicable taxes with respect to such Severance Benefits under applicable law. Executive acknowledges that he is not relying upon the advice or representation of the Company with respect to
the tax treatment of the Severance Benefits. 

  

	19.	Counterparts – This Agreement will be executed in duplicate such that each Party will retain a fully-executed original and each original may be executed in two (2) signature counterparts, each of
which shall constitute an original, but all of which taken together shall constitute but one and the same instrument. 

 IN
WITNESS WHEREOF, the Parties have set their hands and seals to this Agreement as of the date(s) written below. 
 AVEO PHARMACEUTICALS, INC.

  

											
	 /s/ Michael P. Bailey
	  		 	Date:	 	 5/3/17

	By:	 	MICHAEL P. BAILEY	 		  		 		 	


 I hereby agree to the terms and conditions set forth above. i further understand that the Severance
Benefits are conditioned upon my timely execution, return and non-revocation of the Additional Release. 

KEITH EHRLICH 
  

											
	 /s/ KEITH EHRLICH
	 		  		 	Date:	 	 May 3, 2017




  
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 ATTACHMENT A 

ADDITIONAL RELEASE OF CLAIMS 
  

	1.	 Release. In exchange for the consideration set forth in the Transition, Separation and Release of Claims
Agreement (the “Agreement”) to which this Additional Release of Claims (the “Additional Release”) is attached as Attachment A, which Keith Ehlrich (“Executive”) acknowledges he would not otherwise be entitled to
receive, Executive hereby fully, forever, irrevocably and unconditionally releases, remises and discharges the Company, its affiliates, subsidiaries, parent companies, predecessors, and successors, and all of their respective past and present
officers, directors, stockholders, partners, members, employees, agents, representatives, plan administrators, attorneys, insurers and fiduciaries (each in their individual and corporate capacities) (collectively, the “Released Parties”)
from any and all claims, charges, complaints, demands, actions, causes of action, suits, rights, debts, sums of money, costs, accounts, reckonings, covenants, contracts, agreements, promises, doings, omissions, damages, executions, obligations,
liabilities, and expenses (including attorneys’ fees and costs), of every kind and nature that Executive ever had or now has against any or all of the Released Parties, whether known or unknown, including, but not limited to, any and all claims
arising out of or relating to Executive’s employment with and/or separation from the Company, including, but not limited to, all claims under Title VII of the Civil Rights Act, the Americans With Disabilities Act, the Age Discrimination in
Employment Act, the Genetic Information Nondiscrimination Act, the Family and Medical Leave Act, the Worker Adjustment and Retraining Notification Act, the Rehabilitation Act, Executive Order 11246, Executive Order 11141, the Fair Credit Reporting
Act, and the Employee Retirement Income Security Act, all as amended; all claims arising out of the Massachusetts Fair Employment Practices Act, Mass. Gen. Laws ch. 151 B, § 1 et ~’ the Massachusetts Wage Act, Mass. Gen. Laws ch. 149,
§ 148 et seq. (Massachusetts law regarding payment of wages and overtime), the Massachusetts Civil Rights Act, Mass. Gen. Laws ch. 12, §§ 11H and III, the Massachusetts Equal Rights Act, Mass. Gen. Laws. ch. 93, § 102 and Mass.
Gen. Laws ch. 214, § IC, the Massachusetts Labor and Industries Act, Mass. Gen. Laws ch. 149, § 1 et seq., Mass. Gen. Laws ch. 214, § 1B (Massachusetts right of privacy law), the Massachusetts Maternity Leave Act, Mass. Gen.
Laws ch. 149, § 105D, and the Massachusetts Small Necessities Leave Act, Mass. Gen. Laws ch. 149, § 52D, all as amended; all common law claims including, but not limited to, actions in defamation, intentional infliction of emotional
distress, misrepresentation, fraud, wrongful discharge, and breach of contract (including, without limitation, all claims arising out of the Employment Agreement); all claims to any non-vested ownership
interest in the Company, contractual or otherwise; all state and federal whistleblower claims to the maximum extent permitted by law; and any claim or damage arising out of Executive’s employment with and/or separation from the Company
(including a claim for retaliation) under any common law theory or any federal, state or local statute or ordinance not expressly referenced above; provided, however, that nothing in this release of claims prevents Executive from filing a charge
with, cooperating with, or participating in any investigation or proceeding before, the Equal Employment Opportunity Commission or a state fair employment practices agency (except that Executive




  
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	    	acknowledges that he may not recover any monetary benefits in connection with any such charge, investigation, or proceeding, and Executive further waives any rights or claims to any payment, benefit, attorneys
‘fees or other remedial relief in connection with any such charge, investigation or proceeding). This release also does not prevent Executive from reporting possible violations of federal securities laws to government enforcement agencies
without notice to the Company, or from receiving any applicable award for information provided to such government enforcement agencies. 

  

	2.	Final Compensation. Executive acknowledges that he has been reimbursed by the Company for all business expenses incurred in conjunction with the performance of his employment and that no other reimbursements are
owed to him. Executive acknowledges that he has received all compensation due to him from the Company, including, but not limited to, all wages, bonuses and accrued, unused vacation time, and that he is not eligible or entitled to receive any
additional payments or consideration from the Company beyond that provided for in Section 3 of the Agreement. 

  

	3.	Return of Company Property. Executive confirms that he has returned to the Company all keys, files, records (and copies thereof), equipment (including, but not limited to, computer hardware, software and
printers, wireless handheld devices, cellular phones, tablets, etc.), Company identification and any other Company-owned property in his possession or control and that he has left intact all electronic Company documents, including but not limited to
those that he developed or helped to develop during his employment. Executive further confirms that he has cancelled all accounts for his benefit, if any, in the Company’s name, including but not limited to, credit cards, telephone charge
cards, cellular phone and/or wireless data accounts and computer accounts. 

  

	4.	Acknowledgments. Executive acknowledges that he has been given at least twenty-one (21) days to consider this Additional Release, and that the Company has advised him
in writing to consult with an attorney of his own choosing prior to signing this Additional Release. Executive understands that he may revoke this Additional Release for a period of seven (7) days after he signs it by notifying the Company in
writing, and the Additional Release shall not be effective or enforceable until the expiration of this seven (7) day revocation period. Executive understands and agrees that by entering into this Additional Release, he is waiving any and all
rights or claims he might have under the Age Discrimination in Employment Act, as amended by the Older Workers Benefit Protection Act, and that he has received consideration beyond that to which he was previously entitled. 


 

	5.	Voluntary Assent. Executive affirms that no other promises or agreements of any kind have been made to or with him by any person or entity whatsoever to cause him to sign this Additional Release, and that he
fully understands the meaning and intent of this Additional Release. Executive states and represents that he has had an opportunity to fully discuss and review the terms of this Additional Release with an attorney. Executive further states and
represents that he has carefully read this Additional Release, understands the contents herein, freely and voluntarily assents to all of the terms and conditions hereof, and signs his name of his own free act. 


  
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 I hereby provide this Additional Release as of the date below and acknowledge
that the execution of this Additional Release is in further consideration of the Severance Benefits, to which I acknowledge I would not be entitled if I did not enter into this Additional Release. I intend that this Additional Release become
a binding agreement between the Company and me if I do not revoke my acceptance in seven (7) days.  
  

											
	 /s/ Keith Ehrlich
	 		  		 		 	 June 30, 2017

	 Keith Ehrlich
	 		  		 		 	Date


  
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