EXHIBIT 10.2


 


SECURITIES PURCHASE AGREEMENT


 


This SECURITIES PURCHASE
AGREEMENT (this “Agreement”) is made and entered into as of August 2, 2017, by and among Amyris, Inc., a Delaware
corporation (the “Company”), and each of Vivo Capital Fund VIII, L.P., a Delaware limited partnership, and Vivo
Surplus Funds VIII, L.P., a Delaware limited partnership (each, a “Purchaser” and collectively, the “Purchasers”).


 


Preliminary Statement 


 


A.               
The Company and each Purchaser are executing and delivering this Agreement in reliance upon the exemption from registration
afforded by Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), and Rule 506 of
Regulation D (“Regulation D”) as promulgated by the United States Securities and Exchange Commission (the “SEC”)
under the Securities Act.


 


B.                
The Purchasers wishes to purchase and the Company wishes to issue and sell, upon the terms and conditions stated in this
Agreement, an aggregate of (i) 2,826,711 shares of the Company’s common stock (the “Common Stock”),
$0.0001 par value per share (collectively referred to herein as the “Common Shares”), (ii) 12,958.21196 shares
of the Company’s Series D Convertible Preferred Stock, $0.0001
par value per share (collectively referred to herein as the “Preferred Shares” and together with the Common
Shares, the “Shares”), (iii) warrants, in substantially the form attached hereto as Exhibit A (the
“Cash Warrants”), to acquire up to that number of additional shares of Common Stock as determined pursuant to
Article 6 of this Agreement and (iv) warrants, in substantially the form attached hereto as Exhibit B (the “Dilution
Warrants” and together with the Cash Warrants, the “Warrants”)), to acquire up to that number of additional
shares of Common Stock as determined pursuant to the anti-dilution formula set forth therein. The shares of Common Stock issuable
upon exercise of the Warrants and upon conversion of the Preferred Shares are collectively referred to herein as the “Underlying
Shares.”


 


C.                
The Shares, the Warrants and the Underlying Shares issued pursuant to this Agreement are collectively referred to herein
as the “Securities.”


 


D.               
In addition to the transactions contemplated hereby, the Company intends to raise an additional $25,000,000 of working capital
through the sale and issuance to DSM International B.V. (“DSM”) of shares of the Company’s 17.38% Series
B Convertible Preferred Stock and warrants to purchase shares of Common Stock (the “DSM Financing”) in accordance
with the terms of that certain Securities Purchase Agreement dated as of August 2, 2017 and certain related agreements, all in
the forms provided to the Purchaser (collectively, the “DSM Transaction Documents”).


 


Agreement 


 


The parties, intending
to be legally bound, agree as follows:


 






     


     

    

ARTICLE
1

SALE OF SHARES


 


The Purchasers will
purchase from the Company an aggregate of 2,826,711 Common Shares at a price of $4.26 per share in cash and 12,958.21196 Preferred
Shares at a price of $1,000 per share in cash. The total purchase price payable by the Purchasers for the Shares that the Purchasers
are hereby agreeing to purchase is $25,000,000 (the “Purchase Price”). The portion of the Purchase Price and
the Securities issuable to each Purchaser are as set forth on the signature pages to this Agreement of each such Purchaser.


 


ARTICLE
2

CLOSING; DELIVERY


 


2.1.           
Closing. The closing (“Closing”) of the transactions contemplated hereby shall be held
at the offices of Fenwick & West LLP, 801 California Street, Mountain View, California 94041 within one business day following
the date on which the last of the conditions set forth in Articles 5 and 6 have been satisfied or waived in accordance
with this Agreement but in no event later than August 9, 2017 (such date, the “Closing Date”), or at such other
time and place as the Company and the Purchasers mutually agree upon.


 


2.2.           
Delivery. At the Closing, the Company shall execute and deliver to each Purchaser this Agreement, the Stockholder
Agreement in the form attached hereto as Exhibit C (the “Stockholder Agreement”), a Cash Warrant to acquire
up to that number of additional shares of Common Stock as determined pursuant to Article 6 of this Agreement, a Dilution
Warrant and the other documents referenced in Article 6. At the Closing, each Purchaser shall pay the Company the applicable
portion of the Purchase Price in immediately available funds. Promptly following the Closing,
the Company shall deliver to each Purchaser (i) a single stock certificate representing
the number of Common Shares purchased by such Purchaser, as set forth herein, and (ii) a
single stock certificate representing the number of Preferred Shares purchased by such Purchaser, as set forth herein, such
stock certificates to be registered in the name of such Purchaser, or in such nominee’s or nominees’ name(s) as designated
by such Purchaser in writing in the form of the Purchaser Suitability Questionnaire of the Purchaser attached hereto as Exhibit
D (the “Purchaser Suitability Questionnaire”), against payment of the purchase price therefor by wire transfer
of immediately available funds to such account or accounts as the Company shall designate in writing to the Purchasers at least
two days prior to the Closing Date.


 


ARTICLE
3

REPRESENTATIONS AND WARRANTIES OF THE COMPANY


 


The Company represents, warrants and covenants
to the Purchasers, except as set forth in the disclosure letter supplied by the Company to the Purchasers dated as of the date
hereof (the “Disclosure Letter”), which exceptions shall be deemed to be part of the representations and warranties
made hereunder as provided therein, as follows:


 


3.1.           
Organization and Standing. The Company and each of its subsidiaries is duly incorporated, validly existing,
and in good standing under the laws of the jurisdiction of its organization. Each of the Company and its subsidiaries has all requisite
power and authority to own and operate its respective properties and assets and to carry on its respective business as presently
conducted and as proposed to be conducted. The Company and each of its subsidiaries is qualified to do business as a foreign entity
in every jurisdiction in which the failure to be so qualified would have, or would reasonably be expected to have, a material adverse
effect, individually or in the aggregate, upon the business, properties, tangible and intangible assets, liabilities, operations,
prospects, financial condition or results of operation of the Company and its subsidiaries or the ability of the Company or any
of its subsidiaries to perform their respective obligations under the Transaction Agreements (as defined below) (a “Material
Adverse Effect”).


 



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3.2.           
Subsidiaries. As used in this Agreement, references to any “subsidiary” of a specified Person
shall refer to an Affiliate controlled by such Person directly, or indirectly through one or more intermediaries, as such terms
are used in and construed under Rule 405 under the Securities Act (which, for the avoidance of doubt, shall include the Company’s
controlled joint ventures, including shared-controlled joint ventures). The Company’s subsidiaries, as of the date hereof,
are listed on Exhibit 21.01 to the Company’s Annual Report on Form 10-K for the year ended December 31, 2016
and are the only subsidiaries, direct or indirect, of the Company as of the date hereof. All the issued and outstanding shares
of each subsidiary’s capital stock have been duly authorized and validly issued, are fully paid and nonassessable, have been
issued in compliance with all federal and state securities laws, were not issued in violation of or subject to any preemptive rights
or other rights to subscribe for or purchase securities, and, except as set forth on Section 3.2 of the Disclosure Letter,
are owned by the Company or a Company subsidiary free and clear of all liens, encumbrances and equities and claims. As used herein,
“Person” shall mean any individual, corporation, limited liability company, partnership, joint venture, association,
joint-stock company, trust, unincorporated organization or government or any agency or political subdivision thereof, and an “Affiliate”
means, with respect to any Person, any other Person that directly or indirectly controls, is controlled by, or is under common
control with, such Person.


 


3.3.           
Power. The Company has all requisite power to execute and deliver this Agreement, to sell and issue the Securities
hereunder, and to carry out and perform its obligations under the terms of this Agreement, the Warrants, the Stockholder Agreement,
and any ancillary agreements and instruments to be entered into by the Company hereunder (together, the “Transaction Agreements”).


 


3.4.           
Authorization. The execution, delivery, and performance of the Transaction Agreements by the Company has been
duly authorized by all requisite action on the part of the Company and its officers, directors and stockholders, and this Agreement
constitutes, and the other Transaction Agreements will constitute, legal, valid, and binding obligations of the Company enforceable
in accordance with their terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, and other
laws of general application affecting enforcement of creditors’ rights generally, and (b) as limited by laws relating
to the availability of specific performance, injunctive relief or other equitable remedies (together, the “Enforceability
Exceptions”).


 


3.5.           
Consents and Approvals. Except for any Current Report on Form 8-K or Notice of Exempt Offering of Securities
on Form D to be filed by the Company in connection with the transactions contemplated hereby or except as set forth on Section
3.5 of the Disclosure Letter, the Company is not required to give any notice to, make any filing with, or obtain any authorization,
consent, or approval of any government or governmental agency in order to consummate the transactions contemplated by the Transaction
Agreements. Assuming the accuracy of the representations of the Purchasers set forth herein and in the Purchaser Suitability Questionnaire,
no consent, approval, authorization or other order of, or registration, qualification or filing with, any court, regulatory body,
administrative agency, self-regulatory organization, stock exchange or market (including The NASDAQ Stock Market), or other governmental
body is required for the execution and delivery of the Transaction Agreements, the valid issuance, sale and delivery of the Securities
to be sold pursuant to this Agreement other than such as have been or will be made or obtained as of the Closing, or for any securities
filings required to be made under federal or state securities laws applicable to the offering of the Securities.


 



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3.6.           
Non-Contravention. The execution and delivery of the Transaction Agreements, the issuance, sale and delivery
of the Securities to be sold by the Company under this Agreement, the performance by the Company of its obligations under the Transaction
Agreements and/or the consummation of the transactions contemplated thereby will not (a) conflict with, result in the breach
or violation of, or constitute (with or without the giving of notice or the passage of time or both) a violation of, or default
under, (i) any bond, debenture, note or other evidence of indebtedness, or under any lease, license, franchise, permit, indenture,
mortgage, deed of trust, loan agreement, joint venture or other agreement or instrument to which the Company or any subsidiary
is a party or by which it or its properties may be bound or affected, (ii) the Company’s Restated Certificate of Incorporation,
as amended and as in effect on the date hereof (the “Certificate of Incorporation”), the Company’s Bylaws,
as amended and as in effect on the date hereof (the “Bylaws”), or the equivalent document with respect to any
subsidiary, as amended and as in effect on the date hereof, or (iii) any statute or law, judgment, decree, rule, regulation,
ordinance or order of any court or governmental or regulatory body (including The NASDAQ Stock Market), governmental agency, arbitration
panel or authority applicable to the Company, any of its subsidiaries or their respective properties, except in the case of clauses
(i) and (iii) for such conflicts, breaches, violations or defaults that would not be likely to have, individually or
in the aggregate, a Material Adverse Effect, or (b) result in the creation or imposition of any lien, encumbrance, claim,
security interest or restriction whatsoever upon any of the material properties or assets of the Company or any of its subsidiaries
or an acceleration of indebtedness pursuant to any obligation, agreement or condition contained in any material bond, debenture,
note or any other evidence of indebtedness or any material indenture, mortgage, deed of trust or any other agreement or instrument
to which the Company or any if its subsidiaries is a party or by which the Company or any of its subsidiaries is bound or to which
any of the property or assets of the Company is subject. For purposes of this Section 3.6, the term “material”
shall apply to agreements, understandings, instruments, contracts or proposed transactions to which the Company is a party or by
which it is bound involving obligations (contingent or otherwise) of, or payments to, the Company in excess of $100,000 in a consecutive
12-month period.


 


3.7.           
Shares. The Shares are duly authorized and when issued pursuant to the terms of this Agreement will be validly
issued, fully paid, and nonassessable, and will be free of any liens or encumbrances with respect to the issuance thereof; provided,
however, that the Shares shall be subject to restrictions on transfer under state or federal securities laws as set forth
in this Agreement, or as otherwise may be required under state or federal securities laws as set forth in this Agreement at the
time a transfer is proposed. Except as set forth on Section 3.7 of the Disclosure Letter, the issuance and delivery of the
Shares is not subject to preemptive, co-sale, right of first refusal or any other similar rights of the stockholders of the Company
or any other Person, or any liens or encumbrances or result in the triggering of any anti-dilution or other similar rights under
any outstanding securities of the Company.


 



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3.8.           
Authorization of the Warrants. The Warrants have been duly authorized by the Company and, when duly executed
and delivered by the Company, will constitute valid and binding agreements of the Company, enforceable against the Company in accordance
with their terms, subject to the Enforceability Exceptions.


 


3.9.              
Authorization of the Underlying Shares. The Underlying Shares issuable upon conversion of the Preferred Shares
or exercise of the Warrants have been duly authorized and reserved for issuance upon exercise by all necessary corporate action
and such shares, when issued upon such conversion or exercise in accordance of the terms of the applicable Warrant or the Certificate
of Designation of Preferences, Rights and Limitations of Series D Convertible Preferred Stock, in the form of Exhibit E
hereto (the “Certificate of Designation”), as applicable, will be validly issued and will be fully paid and
non-assessable, and will be free of any liens or encumbrances with respect to the issuance thereof; provided, however,
that the Underlying Shares shall be subject to restrictions on transfer under state or federal securities laws as set forth in
this Agreement, or as otherwise may be required under state or federal securities laws as set forth in this Agreement at the time
a transfer is proposed. Except as set forth on Section 3.9 of the Disclosure Letter, the issuance and delivery of the
Underlying Shares is not subject to preemptive, co-sale, right of first refusal or any other similar rights of the stockholders
of the Company or any other Person, or any liens or encumbrances or result in the triggering of any anti-dilution or other similar
rights under any outstanding securities of the Company.


 


3.10.       
No Registration. Assuming the accuracy of each of the representations and warranties of the Purchasers herein
and in the Purchaser Suitability Questionnaire, the issuance by the Company of the Securities is exempt from registration under
the Securities Act.


 


3.11.       
Reporting Status. The Company is subject to the reporting requirements of the Securities Exchange Act of 1934,
as amended (the “Exchange Act”), and, except as set forth in Section 3.11 of the Disclosure Letter, and
the Company has, in a timely manner, filed all documents and reports that the Company was required to file pursuant to Section
I.A.3.b of the General Instructions to Form S-3 promulgated under the Securities Act in order for the Company to be eligible to
use Form S-3 for the two years preceding the Closing Date or such shorter time period as the Company has been subject to such reporting
requirements (the foregoing materials, together with any materials filed by the Company under the Exchange Act, whether or not
required, collectively, the “SEC Documents”). The SEC Documents complied as to form in all material respects
with requirements of the Securities Act and Exchange Act and the rules and regulations of the SEC promulgated thereunder (collectively,
the “SEC Rules”), and none of the SEC Documents and the information contained therein, as of their respective
filing dates, contained any untrue statement of a material fact or omitted to state a material fact required to be stated therein
or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading.
As used in this Agreement, “Previously Disclosed” means information set forth in or incorporated by reference
into the SEC Documents filed with the SEC on or after March 31, 2017 but prior to the date hereof (except for risks and forward-looking
information set forth in the “Risk Factors” section of the applicable SEC Documents or in any forward-looking statement
disclaimers or similar statements that are similarly non-specific and are predictive or forward-looking in nature).


 



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3.12.       
Contracts. Each indenture, contract, lease, mortgage, deed of trust, note agreement, loan or other agreement
or instrument of a character that is required to be described or summarized in the SEC Documents or to be filed as an exhibit to
the SEC Documents under the SEC Rules (collectively, the “Material Contracts”) is so described, summarized or
filed. The Material Contracts to which the Company or its subsidiaries are a party have been duly and validly authorized, executed
and delivered by the Company and constitute the legal, valid and binding agreements of the Company or its subsidiaries, as applicable,
enforceable by and against the Company or its subsidiaries, as applicable, in accordance with their respective terms, subject to
the Enforceability Exceptions. The Company is not party to any contract, side letter, arrangement or agreement or understanding
with DSM related to the transactions contemplated by the DSM Financing, other than the DSM Transaction Documents in the forms provided
to Purchasers. The Company agrees not to enter into any amendment, modification or waiver of any provisions of the DSM Transaction
Documents to the extent such amendment would make the economic terms of the Securities (as defined in the Securities Purchase Agreement
of even date herewith between the Company and DSM) more favorable to DSM without the prior written consent of the Purchasers.


 


3.13.       
Capitalization. As of the date hereof, the authorized capital stock of the Company consists of (a) 250,000,000
shares of Common Stock, $0.0001 par value per share, 25,845,138 shares of which are issued and outstanding as of the date hereof,
and (b) 5,000,000 shares of Preferred Stock, $0.0001 par value per share, of which 3,300 shares of Series A Preferred Stock,
68,395.4779 shares of Series B Preferred Stock, and 0 shares of Series C Preferred Stock are issued and outstanding as of the date
hereof. All subscriptions, warrants, options, convertible securities, and other rights (contingent or other) to purchase or otherwise
acquire equity securities of the Company issued and outstanding as of the date hereof, or material contracts, commitments, understandings,
or arrangements by which the Company or any of its subsidiaries is or may be obligated to issue shares of capital stock, or securities
or rights convertible or exchangeable for shares of capital stock, are as set forth in the SEC Documents. Taking into account all
rights and agreements described in the immediately preceding sentence and any applicable Anti-Dilution Provisions (as defined in
the Disclosure Letter) in any such agreements, immediately after the Closing and after giving effect to the consummation of the
transactions contemplated hereby and consummation of the DSM Financing, (i) the summary capitalization of the Company will be as
set forth on Section 3.13 of the Disclosure Letter; (ii) on an “issued and outstanding” basis, the Purchasers
will own 9.9% of the voting power of the Company; and (iii) on a “fully diluted and as converted” basis (which shall
include all convertible securities and rights to acquire equity securities, regardless of the “strike price” or voting
rights thereof), the Purchasers will own at least 12.7% of the stock of the Company. The issued and outstanding shares of the Company’s
capital stock have been duly authorized and validly issued, are fully paid and nonassessable, have been issued in compliance with
all applicable federal and state securities laws, and were not issued in violation of or subject to any preemptive rights or other
rights to subscribe for or purchase securities. Except as set forth on Section 3.7 of the Disclosure Letter, no holder of
the Company’s capital stock is entitled to preemptive or similar rights. Except as set forth on Section 3.13 of the
Disclosure Letter, there are no bonds, debentures, notes or other indebtedness having general voting rights (or convertible into
securities having such rights) of the Company issued and outstanding. Except as Previously Disclosed, there are no agreements or
arrangements under which the Company or any of its subsidiaries is obligated to register the sale of any of their securities under
the Securities Act. The Company has made available to the Purchasers, a true, correct and complete copy of the Company’s
Certificate of Incorporation and Bylaws.


 



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3.14.       
Legal Proceedings. Except as Previously Disclosed, there is no action, suit or proceeding before any court,
governmental agency or body, domestic or foreign, now pending or, to the knowledge of the Company, threatened against the Company
or its subsidiaries wherein an unfavorable decision, ruling or finding would reasonably be expected to, individually or in the
aggregate, (i) materially adversely affect the validity or enforceability of, or the authority or ability of the Company to
perform its obligations under, this Agreement or (ii) have a Material Adverse Effect. The Company is not a party to or subject
to the provisions of any injunction, judgment, decree or order of any court, regulatory body, administrative agency or other governmental
agency or body that might have, individually or in the aggregate, a Material Adverse Effect.


 


3.15.       
No Violations. Neither the Company nor any of its subsidiaries is in violation of its respective certificate
of incorporation, bylaws or other organizational documents, or to its knowledge, is in violation of any statute or law, judgment,
decree, rule, regulation, ordinance or order of any court or governmental or regulatory body (including The NASDAQ Stock Market),
governmental agency, arbitration panel or authority applicable to the Company or any of its subsidiaries, which violation, individually
or in the aggregate, would be reasonably likely to have a Material Adverse Effect. Neither the Company nor any of its subsidiaries
is in default (and there exists no condition which, with or without the passage of time or giving of notice or both, would constitute
a default) in the performance of any bond, debenture, note or any other evidence of indebtedness in any indenture, mortgage, deed
of trust or any other material agreement or instrument to which the Company or any of its subsidiaries is a party or by which the
Company or any of its subsidiaries is bound or by which the properties of the Company are bound, which would be reasonably likely
to have a Material Adverse Effect. There has not been, and to the knowledge of the Company, there
is not pending or contemplated, any investigation by the SEC involving the Company or any current or former director or officer
of the Company and the Company is not an “ineligible issuer” pursuant to Rules 164, 405 and 433 under the Securities
Act. The Company has not received any comment letter from the SEC relating to any SEC Documents which has not been finally resolved.
The SEC has not issued any stop order or other order suspending the effectiveness of any registration statement filed by
the Company under the Exchange Act or the Securities Act.


 


3.16.       
Governmental Permits; FDA Matters.


 


(a)       Permits.
The Company and its subsidiaries possess all necessary franchises, licenses, certificates and other authorizations from any foreign,
federal, state or local government or governmental agency, department or body that are currently necessary for the operation of
their respective businesses as currently conducted, except where such failure to possess would not reasonably be expected to have,
individually or in the aggregate, a Material Adverse Effect. Neither the Company nor any of its subsidiaries has received any notice
of proceedings relating to the revocation or modification of any such permit which, if the subject of an unfavorable decision,
ruling or finding, could reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect.


 



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(b)       EPA
and FDA Matters. As to each of the manufacturing processes, intermediate products and research or commercial products of the
Company and each of its subsidiaries, including, without limitation, products or compounds currently under research and/or development
by the Company, subject to the jurisdiction of the United States Environmental Protection Agency (“EPA”) under
the Toxic Substances Control Act and regulations thereunder (“TSCA”) or the Food and Drug Administration (“FDA”)
under the Federal Food, Drug and Cosmetic Act and the regulations thereunder (“FDCA”) (each such product, a
“Life Science Product”), such Life Science Product is being researched, developed, manufactured, tested, distributed
and/or marketed in compliance in all material respects with all applicable requirements under the FDCA and TSCA and similar laws
and regulations applicable to such Life Science Product, including those relating to investigational use, premarket approval, good
manufacturing practices, labeling, advertising, record keeping, filing of reports and security. The Company has not received any
notice or other communication from the FDA, EPA or any other federal, state or foreign governmental entity (i) contesting the premarket
approval of, the uses of or the labeling and promotion of any Life Science Product or (ii) otherwise alleging any violation by
the Company of any law, regulation or other legal provision applicable to a Life Science Product. Neither the Company, nor any
officer, employee or agent of the Company has made an untrue statement of a material fact or fraudulent statement to the FDA or
other federal, state or foreign governmental entity performing similar or equivalent functions or failed to disclose a material
fact required to be disclosed to the FDA or such other federal, state or foreign governmental entity.


 


3.17.       
Listing Compliance. The Company is in compliance with the requirements of The NASDAQ Stock Market LLC for
continued listing of the Common Stock thereon and has no knowledge of any facts or circumstances that could reasonably lead to
delisting of its Common Stock from The NASDAQ Stock Market. The Company has taken no action designed to, or likely to have the
effect of, terminating the registration of the Common Stock under the Exchange Act or the listing of the Common Stock on The NASDAQ
Stock Market, nor has the Company received any notification that the SEC or The NASDAQ Stock Market is contemplating terminating
such registration or listing. The transactions contemplated by the Transaction Agreements will not contravene the rules and regulations
of The NASDAQ Stock Market. The Company will comply with all requirements of The NASDAQ Stock Market with respect to the issuance
of the Securities, including the filing of any listing notice with respect to the issuance of the Securities.


 


3.18.       
Intellectual Property.


 


(a)       Except
as set forth in Section 3.18 of the Disclosure Letter or as otherwise Previously Disclosed, or as otherwise would not be reasonably
likely to have, individually or in the aggregate, a Material Adverse Effect, Company and/or its subsidiaries owns or possesses,
free and clear of all encumbrances, all legal rights to all intellectual property and industrial property rights and rights in
confidential information, including all (i) patents, patent applications, invention disclosures, and all related continuations,
continuations-in-part, divisional, reissues, re-examinations, substitutions and extensions thereof, (ii) trademarks, trademark
rights, service marks, service mark rights, corporate names, trade names, trade name rights, domain names, logos, slogans, trade
dress, design rights, and other similar designations of source or origin, together with the goodwill symbolized by and of the foregoing,
(iii) trade secrets and all other confidential information, ideas, know-how, inventions, proprietary processes, formulae, models,
and other methodologies, (iv) copyrights, (v) computer programs (whether in object code, subject code or other form), algorithms,
databases, compilations and data, technology supporting the foregoing, and all related documentation, (vi) licenses to any
of the foregoing, and (vii) all applications and registrations of the foregoing, and (viii) all other similar proprietary rights
(collectively, “Intellectual Property”) used or held for use in, or necessary for the conduct of their businesses
as now conducted and as proposed to be conducted, and neither the Company nor any of its subsidiaries (A) has received any communications
alleging that either the Company or any of its subsidiaries has violated, infringed or misappropriated or, by conducting their
businesses as now conducted and as proposed to be conducted, would violate, infringe or misappropriate any of the Intellectual
Property of any other Person, (B) knows of any claim that the Company or any of its subsidiaries has violated, infringed or misappropriated,
or, by conducting their businesses as now conducted and as proposed to be conducted, would violate, infringe or misappropriate
any of the Intellectual Property of any other Person, and (C) knows of any material third-party infringement, misappropriation
or violation of any Company or any Company subsidiary’s Intellectual Property. The Company has taken and takes reasonable
security measures to protect the secrecy, confidentiality and value of its Intellectual Property, including requiring all Persons
with access thereto to enter into appropriate non-disclosure agreements. To the knowledge of the Company, there has not been any
disclosure of any material trade secret of the Company or a Company subsidiary (including any such information of any other Person
disclosed in confidence to the Company) to any other Person in a manner that has resulted or is likely to result in the loss of
trade secret in and to such information. Except as Previously Disclosed, and except as would not reasonably be expected to have,
individually or in the aggregate, a Material Adverse Effect, there are no outstanding options, licenses or agreements, claims,
encumbrances or shared ownership interests of any kind relating to the Company’s or its subsidiaries’ Intellectual
Property, nor is the Company or its subsidiaries bound by or a party to any options, licenses or agreements of any kind with respect
to the Intellectual Property of any other Person. 



 



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(b)       To
the Company’s knowledge, none of the employees of the Company or its subsidiaries are obligated under any contract (including,
without limitation, licenses, covenants or commitments of any nature or contracts entered into with prior employers), or subject
to any judgment, decree or order of any court or administrative agency, that would interfere with the use of his or her best efforts
to promote the interests of the Company or its subsidiaries or would conflict with their businesses as now conducted and as proposed
to be conducted. Neither the execution nor delivery of the Transaction Agreements will conflict with or result in a breach of the
terms, conditions or provisions of, or constitute a default under any contract, covenant or instrument under which the Company
or its subsidiaries or any of the employees of the Company or its subsidiaries is now obligated, and neither the Company nor its
subsidiaries will need to use any inventions that any of its employees, or Persons it currently intends to employ, have made prior
to their employment with the Company or its subsidiaries, except for inventions that have been assigned or licensed to the Company
or its subsidiaries as of the date hereof. Each current and former employee or contractor of the Company or its subsidiaries that
has developed any Intellectual Property owned or purported to be owned by the Company or its subsidiaries has executed and delivered
to the Company a valid and enforceable Invention Assignment and Confidentiality Agreement that (i) assigns to the Company or such
subsidiaries all right, title and interest in and to any Intellectual Property rights arising from or developed or delivered to
the Company or such subsidiaries in connection with such Person’s work for or on behalf of the Company or such subsidiaries,
and (ii) provides reasonable protection for the trade secrets, know-how and other confidential information (1) of the Company or
such subsidiaries and (2) of any third party that has disclosed same to the Company or such subsidiaries. To the knowledge of the
Company, no current or former employee, officer, consultant or contractor is in default or breach of any term of any employment,
consulting or contractor agreement, non-disclosure agreement, assignment agreement, or similar agreement. Except as Previously
Disclosed, to the knowledge of the Company, no present or former employee, officer, consultant or contractor of the Company has
any ownership, license or other right, title or interest, directly or indirectly, in whole or in part, in any Intellectual Property
that is owned or purported to be owned, in whole or part, by the Company or its subsidiaries.


 



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3.19.       
Financial Statements. The consolidated financial statements of the Company and its subsidiaries and the related
notes thereto included in the SEC Documents (the “Financial Statements”) comply in all material respects with
applicable accounting requirements and the rules and regulations of the SEC with respect thereto as in effect at the time of filing
and present fairly, in all material respects, the financial position of the Company and its subsidiaries as of the dates indicated
and the results of its operations and cash flows for the periods therein specified subject, in the case of unaudited statements,
to normal year-end audit adjustments. Except as set forth in such Financial Statements (or the notes thereto), such Financial Statements
(including the related notes) have been prepared in accordance with U.S. generally accepted accounting principles applied on a
consistent basis throughout the periods therein specified (“GAAP”). Except as set forth in the Financial Statements,
neither the Company nor its subsidiaries has any material liabilities other than liabilities and obligations that have arisen in
the ordinary course of business and which would not be required to be reflected in financial statements prepared in accordance
with GAAP.


 


3.20.       
Accountants. PricewaterhouseCoopers LLP, which has expressed its opinion with respect to the consolidated
financial statements contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016,
are registered independent public accountants as required by the Exchange Act and the rules and regulations promulgated thereunder
(and by the rules of the Public Company Accounting Oversight Board).


 


3.21.       
Internal Accounting Controls. The Company maintains a system of internal accounting controls sufficient to
provide reasonable assurances that (i) transactions are executed in accordance with management’s general or specific
authorizations; (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with
GAAP and to maintain accountability for assets; (iii) access to assets is permitted only in accordance with management’s
general or specific authorization; and (iv) the recorded accountability for assets is compared with existing assets at reasonable
intervals and appropriate action is taken with respect to any differences. The Company has disclosure controls and procedures (as
defined in Rules 13a-14 and 15d-14 under the Exchange Act) that are effective and designed to ensure that (i) information
required to be disclosed in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and
reported, within the time periods specified by the SEC Rules, and (ii) such information is accumulated and communicated to the
Company’s management, including its principal executive officer and principal financial officer, to allow timely decisions
regarding required disclosure. The Company is otherwise in compliance in all material respects with all applicable provisions of
the Sarbanes-Oxley Act of 2002, as amended and the rules and regulations promulgated thereunder.


 



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3.22.       
Off-Balance Sheet Arrangements. There is no transaction, arrangement or other relationship between the Company
or its subsidiaries and an unconsolidated or other off-balance sheet entity that is required to be disclosed by the Company in
its Exchange Act filings and is not so disclosed or that otherwise would be reasonably likely to have, individually or in the aggregate,
a Material Adverse Effect. There are no such transactions, arrangements or other relationships with the Company that may create
contingencies or liabilities that are not otherwise disclosed by the Company in its Exchange Act filings.


 


3.23.       
No Material Adverse Change. (a) Except as set forth in the SEC Documents, in each case, filed or made through
and including the date hereof (but excluding any documents incorporated by reference to such SEC Documents, but including any exhibits
to such SEC Documents), since March 31, 2017:


 


(i)        there
has not been any event, occurrence or development that, individually or in the aggregate, has had or that could reasonably
be expected to result in a Material Adverse Effect,


 


(ii) the
Company has not incurred any liabilities (contingent or otherwise) other than (1) trade payables and accrued expenses incurred
in the ordinary course of business consistent with past practice and (2) liabilities not required to be reflected in the Company's
financial statements pursuant to GAAP or not required to be disclosed in filings made with the SEC,


 


(iii) the
Company has not declared or made any dividend or distribution of cash or other property to its stockholders or purchased, redeemed
or made any agreements to purchase or redeem any shares of its capital stock other than routine withholding in accordance with
the Company’s existing stock-based plan,


 


(iv)       the
Company has not altered its method of accounting or the identity of its auditors, except as Previously Disclosed,


 


(v)       the
Company has not issued any equity securities except pursuant to the Company’s existing stock based plans, upon conversion,
exercise, repayment or exchange of the Company’s existing securities, or as otherwise Previously Disclosed; and


 


(vi)       there
has not been any loss or damage (whether or not insured) to the physical property of the Company or any of its subsidiaries.


 


(b)       The
Company is not as of the date hereof, and after giving effect to the transactions contemplated hereby to occur at the Closing,
will not be Insolvent (as defined below). For purposes of this Section, “Insolvent” means, with respect to any
Person, (i) the present fair saleable value of such Person’s assets is less than the amount required to pay such Person’s
total indebtedness, (ii) such Person is unable to pay its debts and liabilities, subordinated, contingent or otherwise, as such
debts and liabilities become absolute and matured, (iii) such Person intends to incur or believes that it will incur debts that
would be beyond its ability to pay as such debts mature or (iv) such Person has unreasonably small capital with which to conduct
the business in which it is engaged as such business is now conducted and is currently proposed to be conducted.


 



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(c)       The
Company has not incurred any obligation or liability (contingent or otherwise) under this Agreement, or any of the documents or
instruments contemplated hereby, with actual intent to hinder, delay or defraud either present or future creditors of the Company
or any of its subsidiaries.


 


3.24.       
No Manipulation of Stock. Neither the Company nor any of its subsidiaries, nor to the Company’s knowledge,
any of their respective officers, directors, employees, Affiliates or controlling Persons has taken and will not, in violation
of applicable law, take, any action designed to or that might reasonably be expected to, directly or indirectly, cause or result
in stabilization or manipulation of the price of the Common Stock.


 


3.25.       
Insurance. The Company and its subsidiaries are insured by insurers of recognized financial responsibility
against such losses and risks and in such amounts as are prudent and customary in the businesses in which the Company and its subsidiaries
are engaged. The Company and its subsidiaries will continue to maintain such insurance
or substantially similar insurance, which covers the same risks at the same levels
as the existing insurance with insurers which guarantee the same financial responsibility as the current insurers, and neither
the Company nor any subsidiary has any reason to believe that it will not be able to renew its existing insurance coverage as and
when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to continue its business without
a significant increase in cost.


 


3.26.       
Properties. Except as Previously Disclosed, the Company and its subsidiaries have good and marketable title
to all the properties and assets (both tangible and intangible) described as owned by them in the consolidated financial statements
included in the SEC Documents, free and clear of all liens, mortgages, pledges, or encumbrances of any kind except (i) those,
if any, reflected in such consolidated financial statements (including the notes thereto), or (ii) those that are not material
in amount and do not adversely affect the use made and proposed to be made of such property by the Company or its subsidiaries.
The Company and each of its subsidiaries hold their leased properties under valid and binding leases. The Company and each of its
subsidiaries own or lease all such properties as are necessary to its operations as now conducted.


 


3.27.       
Tax Matters. The Company and its subsidiaries have filed all Tax Returns, and these Tax Returns are true,
correct, and complete in all material respects. The Company and each subsidiary (i) have paid all Taxes that are due from the Company
or such subsidiary for the periods covered by the Tax Returns or (ii) have duly and fully provided reserves adequate to pay all
Taxes in accordance with GAAP. No agreement as to indemnification for, contribution to, or payment of Taxes exists between the
Company or any subsidiary, on the one hand, and any other Person, on the other, including pursuant to any Tax sharing agreement,
lease agreement, purchase or sale agreement, partnership agreement or any other agreement not entered into in the ordinary course
of business. Neither the Company nor any of its subsidiaries has any liability for Taxes of any Person (other than the Company
or any of its subsidiaries) under Treasury Regulation Section 1.1502-6 (or any similar provision of any state, local or foreign
law), or as a transferee or successor, by contract or otherwise. Since the date of the Company's most recent Financial Statements,
the Company has not incurred any liability for Taxes other than in the ordinary course of business consistent with past practice.
Neither the Company nor its subsidiaries has been advised (a) that any of its Tax Returns have been or are being audited as of
the date hereof, or (b) of any deficiency in assessment or proposed judgment to its Taxes. Neither the Company nor any of
its subsidiaries has knowledge of any Tax liability to be imposed upon its properties or assets as of the date of this Agreement
that is not adequately provided for. The Company has not distributed stock of another corporation, or has had its stock distributed
by another corporation, in a transaction that was governed, or purported or intended to be governed, in whole or in part, by Section
355 of the Internal Revenue Code (i) in the two years prior to the date of this Agreement or (ii) in a distribution that could
otherwise constitute part of a “plan” or “series of related transactions” (within the meaning of Section
355(e) of the Internal Revenue Code) in conjunction with the purchase of the Shares. “Tax” or “Taxes”
means any foreign, federal, state or local income, gross receipts, license, payroll, employment, excise, severance, stamp, occupation,
premium, property, windfall, profits, environmental, customs, capital stock, franchise, employees’ income withholding, foreign
or domestic withholding, social security, unemployment, disability, real property, personal property, sales, use, transfer, value
added, alternative or add-on minimum or other similar tax, governmental fee, governmental assessment or governmental charge, including
any interest, penalties or additions to Taxes or additional amounts with respect to the foregoing. “Tax Returns”
means all returns, reports, or statements required to be filed with respect to any Tax (including any elections, notifications,
declarations, schedules or attachments thereto, and any amendment thereof) including any information return, claim for refund,
amended return or declaration of estimated Tax.


 



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3.28.       
Investment Company Status. The Company is not, and immediately after receipt of payment for the Shares will
not be, an “investment company,” an “affiliated person” of, “promoter” for or “principal
underwriter” for, or an entity “controlled” by an “investment company,” within the meaning of the
Investment Company Act of 1940, as amended, or the rules and regulations promulgated thereunder.


 


3.29.       
Transactions With Affiliates and Employees. Except as set forth in the Company’s Definitive Proxy Statements
filed on April 27, 2017, April 15, 2016 and April 6, 2015 or as set forth in Section 3.29 of the Disclosure Letter, none of the
officers or directors of the Company or its subsidiaries and, to the knowledge of the Company, none of the employees of the Company
or its subsidiaries is presently a party to any transaction with the Company or any subsidiary (other than for services as employees,
officers and directors) required to be disclosed under Item 404 of Regulation S-K under the Exchange Act.


 


3.30.       
Foreign Corrupt Practices. Neither the Company nor its subsidiaries or Affiliates,
any director or officer, nor to the knowledge of the Company, any agent, employee or other Person acting on behalf of the Company
or its subsidiaries has, in the course of its actions for, or on behalf of, the Company or any of its subsidiaries (a) used
any corporate funds for any unlawful contribution, gift, entertainment or other unlawful expenses relating to political activity,
(b) made or promised to make any direct or indirect unlawful payment to any foreign or domestic government official or employee
(including any officer or employee of a government or government-owned or controlled entity or of a public international organization,
or any Person acting in an official capacity for or on behalf of any of the foregoing, or of any political party or part official
or candidate for political office (each such Person, a “Government Official”)) from corporate funds, (c) violated
or is in violation of any provision of the U.S. Foreign Corrupt Practices Act of 1977, as amended or (d) made or promised
to make any unlawful bribe, rebate, payoff, influence payment, kickback or other unlawful payment to any foreign or domestic Government
Official. 


 



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3.31.       
Money Laundering Laws. The operations of the Company and its subsidiaries are
and have been conducted at all times in compliance with applicable financial record-keeping and reporting requirements of the Currency
and Foreign Transactions Reporting Act of 1970, as amended, and the Bank Secrecy Act, as amended by Title III of the Uniting and
Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act of 2001 (Title III of Pub.
L. 107-56 (signed into law on October 26, 2001)), applicable money laundering statutes and applicable rules and regulations thereunder
(collectively, the “Money Laundering Laws”), and no action, suit or proceeding by or before any court or governmental
agency, authority or body or any arbitrator involving the Company or any of its subsidiaries with respect to the Money Laundering
Laws is pending or, to the Company’s knowledge, threatened. 


 


3.32.       
OFAC. Neither the Company, any director or officer, nor, to the Company’s
knowledge, any agent, employee, subsidiary or Affiliate of the Company is currently subject to any U.S. sanctions administered
by the Office of Foreign Assets Control of the U.S. Treasury Department (“OFAC”); and the Company will not directly
or indirectly use the proceeds of the offering, or lend, contribute or otherwise make available such proceeds to any subsidiary,
joint venture partner or other Person, for the purpose of financing the activities of any Person currently subject to any U.S.
sanctions administered by OFAC. 


 


3.33.       
Environmental Laws. The Company and its subsidiaries (i) are in compliance with any and all applicable
foreign, federal, state and local laws and regulations relating to the protection of human health and safety, the environment or
hazardous or toxic substances or wastes, pollutants or contaminants (“Environmental Laws”), (ii) have received
all permits, licenses or other approvals required of them under applicable Environmental Laws to conduct their respective businesses
and (iii) are in compliance with all terms and conditions of any such permit, license or approval, except where such noncompliance
with Environmental Laws, failure to receive required permits, licenses or other approvals or failure to comply with the terms and
conditions of such permits, licenses or approvals would not, singly or in the aggregate, have a Material Adverse Effect on the
Company and its subsidiaries, taken as a whole. There are no costs or liabilities associated with Environmental Laws (including,
without limitation, any capital or operating expenditures required for clean-up, closure of properties or compliance with Environmental
Laws or any permit, license or approval, any related constraints on operating activities and any potential liabilities to third
parties) which would, singly or in the aggregate, have a Material Adverse Effect on the Company and its subsidiaries, taken as
a whole.


 


3.34.       
Employee Relations. Except as set forth in Section 3.34 of the Disclosure Letter, neither the Company nor
any of its subsidiaries is a party to any collective bargaining agreement or employs any member of a union. Neither the Company
nor any of its subsidiaries is engaged in any unfair labor practice. There is (i) (x) no unfair labor practice complaint pending
or, to the Company’s knowledge, threatened against the Company or any of its subsidiaries before the National Labor Relations
Board, and no grievance or arbitration proceeding arising out of or under collective bargaining agreements is pending or threatened,
(y) no strike, labor dispute, slowdown or stoppage pending or, to the Company’s knowledge, threatened against the Company
or any of its subsidiaries and (z) no union representation dispute currently existing concerning the employees of the Company
or any of its subsidiaries, and (ii) to the Company’s knowledge, (x) no union organizing activities are currently
taking place concerning the employees of the Company or any of its subsidiaries and (y) there has been no violation of any
federal, state, local or foreign law relating to discrimination in the hiring, promotion or pay of employees or any applicable
wage or hour laws. No executive officer of the Company (as defined in Rule 501(f) promulgated under the Securities Act)
has notified the Company that such officer intends to leave the Company or otherwise terminate such officer’s employment
with the Company. No executive officer of the Company, to the knowledge of the Company, is, or is now expected to be, in violation
of any material term of any employment contract, confidentiality, disclosure or proprietary information agreement, non-competition
agreement, or any other agreement or any restrictive covenant, and the continued employment of each such executive officer does
not subject the Company or any of its subsidiaries to any liability with respect to any of the foregoing matters.


 



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3.35.       
ERISA. The Company and its subsidiaries are in compliance in all material respects with all presently applicable
provisions of the Employee Retirement Income Security Act of 1974, as amended, including the regulations and published interpretations
thereunder (herein called “ERISA”); no “reportable event” (as defined in ERISA) has occurred with
respect to any “pension plan” (as defined in ERISA) for which the Company or any of its subsidiaries would have any
liability; the Company has not incurred and does not expect to incur liability under (i) Title IV of ERISA with respect to
termination of, or withdrawal from, any “pension plan”; or (ii) Sections 412 or 4971 of the Internal Revenue Code
of 1986, as amended, including the regulations and published interpretations thereunder (the “Code”); and each
“Pension Plan” for which the Company would have liability that is intended to be qualified under Section 401(a) of
the Code is so qualified in all material respects and nothing has occurred, whether by action or by failure to act, which would
cause the loss of such qualification.


 


3.36.       
Obligations of Management. To the Company’s knowledge, each officer and key employee of the Company
or its subsidiaries is currently devoting substantially all of his or her business time to the conduct of the business of the Company
or its subsidiaries, respectively. The Company is not aware that any officer or key employee of the Company or its subsidiaries
is planning to work less than full time at the Company or its subsidiaries, respectively, in the future. To the Company’s
knowledge, no officer or key employee is currently working or plans to work for a competitive enterprise, whether or not such officer
or key employee is or will be compensated by such enterprise. To the Company’s knowledge, no officer or Person currently
nominated to become an officer of the Company or its subsidiaries is or has been subject to any judgment or order of, the subject
of any pending civil or administrative action by the SEC or any self-regulatory organization.


 


3.37.       
Integration; Other Issuances of Securities. Except as set forth in Section 3.37 of the Disclosure Letter,
neither the Company nor its subsidiaries or any Affiliates, nor any Person acting on its or their behalf, has issued any shares
of Common Stock or shares of any series of preferred stock or other securities or instruments convertible into, exchangeable for
or otherwise entitling the holder thereof to acquire shares of Common Stock which would be integrated with the sale or exchange
of the Securities to the Purchasers for purposes of the Securities Act or of any applicable stockholder approval provisions, including,
without limitation, under the rules and regulations of The NASDAQ Stock Market, nor will the Company or its subsidiaries or Affiliates
take any action or steps that would require registration of any of the Securities under the Securities Act or cause the offering
of the Securities to be integrated with other offerings if any such integration would cause the issuance of the Securities hereunder
to fail to be exempt from registration under the Securities Act as provided in Section 3.10 above or cause the transactions
contemplated hereby to contravene the rules and regulations of The NASDAQ Stock Market.


 



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3.38.       
No General Solicitation. Neither the Company nor its subsidiaries or any Affiliates, nor any Person acting
on its or their behalf, has offered or sold any of the Securities by any form of general solicitation or general advertising.


 


3.39.       
No Brokers’ Fees. The Company has not incurred any liability for any finder’s or broker’s
fee or agent’s commission in connection with the execution and delivery of this Agreement or the consummation of the transactions
contemplated hereby.


 


3.40.       
Registration Rights. Except as set forth in (i) the Registration Rights Agreement, dated July 30, 2012, by
and between the Company and Total Raffinage Chimie S.A. (“Total”), (ii) the Amended and Restated Letter Agreement
dated May 8, 2014, by and among the Company and note holders party thereto; (iii) the Registration Rights Agreement, dated February
24, 2015, by and between the Company and Nomis Bay Ltd.; (iv) the Letter Agreement, dated July 29, 2015, by and among the Company
and certain investors listed on the signature pages thereto, (v) the Registration Rights Agreement, dated October 20, 2015, by
and among the Company and certain purchasers listed on the signature pages thereto, (vi) the warrant to purchase common stock issued
by the Company to Nenter & Co., Inc. on November 16, 2016, (vii) the Securities Purchase Agreement, dated May 8, 2017, by and
among the Company and certain investors listed on the signature pages thereto, (viii) the Stockholder Agreement, dated May 11,
2017, as amended and restated from time to time, between the Company and DSM, and (ix) the Securities Purchase Agreement, dated
May 31, 2017, between the Company and John E. Abdo, As Trustee Under Trust Agreement Dated March 15, 1976 For The Benefit Of John
E. Abdo, the Company has not granted or agreed to grant to any Person any rights (including “piggy-back” registration
rights) to have any securities of the Company registered with the SEC or any other governmental authority that have not been satisfied
or waived.


 


3.41.       
Application of Takeover Protections. There is no control share acquisition, business combination, poison pill
(including any distribution under a rights agreement) or other similar anti-takeover provision under the Company’s charter
documents or the laws of its state of incorporation that is or could become applicable to the Purchasers as a result of the Purchasers
and the Company fulfilling their obligations or exercising their rights under the Transaction Agreements, including, without limitation,
as a result of the Company’s issuance of the Securities and the Purchasers’ ownership of the Securities.


 



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3.42.       
No Disqualification. No “bad actor” disqualifying event described in Rule 506(d)(1)(i)-(viii)
of the Securities Act (a “Disqualification Event”) is applicable to the Company or, to the Company’s knowledge,
any Company Covered Person, except for a Disqualification Event as to which Rule 506(d)(2)(ii–iv) or (d)(3), is applicable.
As used herein, “Company Covered Person” means, with respect to the Company as an “issuer” for purposes
of Rule 506 promulgated under the Securities Act, any Person listed in the first paragraph of Rule 506(d)(1).


 


3.43.       
Disclosure. The Company understands and confirms that the Purchasers will rely on the foregoing representations
in effecting transactions in the Securities. All disclosure furnished by or on behalf of the Company to the Purchasers in connection
with this Agreement regarding the Company, its business and the transactions contemplated hereby is true and correct in all material
respects and does not contain any untrue statement of a material fact or omit to state any material fact necessary in order to
make the statements made therein, in light of the circumstances under which they were made, not misleading. The Company acknowledges
and agrees that neither Purchaser has made nor makes any representations or warranties with respect to the transactions contemplated
hereby other than those set forth in Article 4 hereto or in the Purchaser Suitability Questionnaire.


 


3.44.       
Acknowledgement Regarding Purchasers’ Purchase of Securities. The Company acknowledges and agrees that
the Purchasers are acting solely in the capacity of an arm’s length purchaser with respect to the Transaction Agreements
and the transactions contemplated thereby. The Company further acknowledges that the Purchasers are not acting as a financial advisor
or fiduciary of the Company (or in any similar capacity) with respect to the Transaction Agreements and the transactions contemplated
thereby and any advice given by the Purchasers or any of their respective representatives or agents in connection with the Transaction
Agreements and the transactions contemplated thereby is merely incidental to the Purchasers’ purchase of the Securities.
The Company further represents to the Purchasers that the Company’s decision to enter into this Agreement and the other Transaction
Agreements has been based solely on the independent evaluation of the transactions contemplated hereby by the Company and its representatives.


 


ARTICLE
4

REPRESENTATIONS AND WARRANTIES OF THE PURCHASERs


 


Each Purchaser, severally
and not jointly, represents, warrants and covenants to the Company with respect to this purchase as follows:


 


4.1.           
Organization. The Purchaser is duly organized, validly existing, and in good standing under the laws of the
jurisdiction of its organization.


 


4.2.           
Power. The Purchaser has all requisite power to execute and deliver this Agreement and to carry out and perform
its obligations under the terms of this Agreement.


 


4.3.           
Authorization. The execution, delivery, and performance of this Agreement by the Purchaser has been duly authorized
by all requisite action, and this Agreement constitutes the legal, valid, and binding obligation of the Purchaser enforceable in
accordance with its terms, except as limited by the Enforceability Exceptions.


 



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4.4.           
Consents and Approvals. The Purchaser need not give any notice to, make any filing with, or obtain any authorization,
consent, or approval of any government or governmental agency in order to consummate the transactions contemplated by this Agreement.


 


4.5.           
Non-Contravention. Neither the execution and the delivery of this Agreement, nor the consummation of the transactions
contemplated hereby, will violate in any material respect any constitution, statute, regulation, rule, injunction, judgment, order,
decree, ruling, charge, or other restriction of any government, governmental agency, or court to which the Purchaser is subject.
No approval, waiver, or consent by the Purchaser under any instrument, contract, or agreement to which the Purchaser or any of
its Affiliates is a party is necessary to consummate the transactions contemplated hereby.


 


4.6.           
Purchase for Investment Only. The Purchaser is purchasing the Securities for the Purchaser’s own account
for investment purposes only and not with a view to, or for resale in connection with, any “distribution” in violation
of the Securities Act. By executing this Agreement, the Purchaser further represents that it does not have any contract, undertaking,
agreement, or arrangement with any Person to sell, transfer, or grant participation to such Person or to any third Person, with
respect to any of the Securities. The Purchaser understands that the Securities have not been registered under the Securities Act
or any applicable state securities laws by reason of a specific exemption therefrom that depends upon, among other things, the
bona fide nature of the investment intent as expressed herein.


 


4.7.           
Disclosure of Information. The Purchaser has had an opportunity to review the Company’s filings under
the Securities Act and the Exchange Act (including risks factors set forth therein) and the Purchaser represents that it has had
an opportunity to ask questions and receive answers from the Company to evaluate the financial risk inherent in making an investment
in the Securities. The Purchaser has not been offered the opportunity to purchase the Securities by means of any general solicitation
or general advertising.


 


4.8.           
Risk of Investment. The Purchaser realizes that the purchase of the Securities will be a highly speculative
investment and the Purchaser may suffer a complete loss of its investment. The Purchaser understands all of the risks related to
the purchase of the Securities. By virtue of the Purchaser’s experience in evaluating and investing in private placement
transactions of securities in companies similar to the Company, the Purchaser is capable of evaluating the merits and risks of
the Purchaser’s investment in the Company and has the capacity to protect the Purchaser’s own interests.


 


4.9.           
Advisors. The Purchaser has reviewed with its own tax advisors the federal, state, and local tax consequences
of this investment and the transactions contemplated by this Agreement. The Purchaser acknowledges that it has had the opportunity
to review the Transaction Agreements and the transactions contemplated thereby with the Purchaser’s own legal counsel.


 


4.10.       
Finder. The Purchaser is not obligated and will not be obligated to pay any broker commission, finders’
fee, success fee, or commission in connection with the transactions contemplated by this Agreement.


 



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4.11.       
Restricted Securities. The Purchaser understands that the Securities must be held indefinitely unless subsequently
registered under the Securities Act or unless an exemption from registration is otherwise available. Moreover, the Purchaser understands
that the Company is under no obligation to register the Shares, the Warrants or the Underlying Shares. The Purchaser is aware of
Rule 144 promulgated under the Securities Act (“SEC Rule 144”) that permits limited resales of securities purchased
in a private placement subject to the satisfaction of certain conditions.


 


4.12.       
Legend. It is understood by the Purchaser that each certificate or other instrument representing the Shares,
the Warrants or the Underlying Shares shall be endorsed with a legend substantially in the following form:


 


“NEITHER
THIS SECURITY NOR THE SECURITIES INTO WHICH THIS SECURITY IS CONVERTIBLE OR EXERCISABLE HAVE BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR
ASSIGNED (I) IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, OR (B) AN OPINION OF COUNSEL TO THE HOLDER (IF REQUESTED BY THE COMPANY), IN A FORM REASONABLY ACCEPTABLE TO THE COMPANY,
THAT REGISTRATION IS NOT REQUIRED UNDER SAID ACT OR (II) UNLESS SOLD OR ELIGIBLE TO BE SOLD PURSUANT TO RULE 144 UNDER SAID ACT.
NOTWITHSTANDING THE FOREGOING, THE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN OR FINANCING
ARRANGEMENT SECURED BY THE SECURITIES.”


 


Subject to Section
7.3, the Company need not register a transfer of Securities unless the conditions specified in the foregoing legend are satisfied.
Subject to Section 7.3, the Company may also instruct its transfer agent not to register the transfer of any of the Securities
unless the conditions specified in the foregoing legend are satisfied.


 


4.13.       
Investor Qualification. The Purchaser is an “accredited investor” as defined in Rule 501(a) of
Regulation D under the Securities Act. The Purchaser acknowledges that it has completed the Purchaser Suitability Questionnaire.
The Purchaser has truthfully set forth in the Purchaser Suitability Questionnaire the factual basis or reason for qualification
as an “accredited investor” as defined in Rule 501(a) of Regulation D under the Securities Act and such information
remains true and correct as of the date hereof. The Purchaser agrees to furnish any additional information that the Company deems
reasonably necessary in order to verify the answers set forth in the Purchaser Suitability Questionnaire.


 


4.14.       
Disqualification. The Purchaser represents that neither the Purchaser, nor any person or entity with whom
the Purchaser shares beneficial ownership of the Company securities, is subject to any Disqualification Event (as defined in Rule
506(d)(1)(i) through (viii) under the Securities Act), except for Disqualification Events covered by Rule 506(d)(2)(ii) or (iii)
or (d)(3) under the Securities Act and disclosed reasonably in advance of the Closing in writing in reasonable detail to the Company.


 



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The Company acknowledges and agrees that
the representations contained in this Article 4 and in the Purchaser Suitability Questionnaire shall not modify, amend or affect
the Purchasers’ right to rely on the Company’s representations and warranties contained in this Agreement or any other
Transaction Agreement or any other documents or instruments executed and/or delivered in connection with this Agreement or the
consummation of the transactions contemplated hereby.


 


ARTICLE
5

CONDITIONS TO COMPANY’S OBLIGATIONS AT THE CLOSING


 


The Company’s
obligation to complete the sale and issuance of the Shares and Warrants and deliver the Shares and Warrants to the Purchasers at
the Closing shall be subject to the following conditions to the extent not waived by the Company:


 


(a)        Receipt
of Payment. The Company shall have received payment by wire transfer of immediately available funds in the full amount of the
Purchase Price for the Shares being purchased by the Purchasers at the Closing, as set forth herein.


 


(b)        Representations
and Warranties. The representations and warranties made by the Purchasers in Section 4 hereof shall be true and
correct in all material respects as of, and as if made on, the date of this Agreement and as of the Closing.


 


(c)        Receipt
of Executed Documents. The Purchasers shall have duly executed and delivered to the Company the Purchaser Suitability Questionnaire
and the Stockholder Agreement.


 


ARTICLE
6

CONDITIONS TO PURCHASERS’ OBLIGATIONS AT THE CLOSING


 


The Purchasers’
obligation to accept delivery of the Shares and Warrants and to pay for the Shares and Warrants shall be subject to the following
conditions to the extent not waived by the Purchasers:


 


(a)        Representations
and Warranties. The representations and warranties made by the Company in Section 3 hereof shall be true and correct
in all respects as of, and as if made on, the date of this Agreement and as of the Closing.


 


(b)        Officers’
Certificate. The Purchasers shall have received a certificate signed by the Company’s Chief Executive Officer and Chief
Financial Officer to the effect that the representations and warranties of the Company in Section 3 hereof are true
and correct in all respects as of, and as if made on, the date of this Agreement and, except for the representations and warranties
set forth in the third sentence of Section 3.13, which are made solely as of the date of this Agreement, as of the Closing Date,
and that the Company has satisfied in all material respects all of the conditions set forth in this Agreement.


 


(c)        Good
Standing. The Company is validly existing as a corporation in good standing under the laws of Delaware as evidenced by a certificate
of the Secretary of State of the State of Delaware, a copy of which was provided to the Purchasers.


 



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(d)       Secretary’s
Certificate. A certificate, executed by the Secretary or the Assistant Secretary of the Company and dated as of the Closing
Date, as to (A) the resolutions approving the issuance of the Securities as adopted by an Independent Committee of the Board
of Directors and/or the Company’s Board of Directors, (B) the certificate of incorporation, and (C) the bylaws, each as in
effect as of the Closing Date.


 


(e)       Board
Approval. The terms and conditions of the issuance of the Securities and the Transaction Agreements shall have been approved
by an Independent Committee of the Board of Directors and/or a majority of the disinterested directors of the Board of Directors,
as applicable.


 


(f)       Approvals.
The Company shall have obtained all governmental, regulatory or third party consents and approvals, if any, necessary for the sale
of the Securities.


 


(g)       Warrants.
The Company shall have issued to the Purchasers (i) the Cash Warrants, which Cash Warrants will be exercisable for an aggregate
of 5,575,118 shares of Common Stock at an exercise price of $6.39 per share and (ii) the Dilution Warrants, which Dilution Warrant
will be exercisable for the number of shares of Common Stock as determined pursuant to the anti-dilution formula set forth therein
at an exercise price of $0.0001 per share.


 


(h)       Receipt
of Stockholder Agreement. The Company shall have executed and delivered to the Purchasers the Stockholder Agreement in the
form attached hereto as Exhibit B.


 


(i)       Certificate
of Designation. The Certificate of Designation, in the form of Exhibit E hereto, shall have been filed with the Delaware
Secretary of State.


 


(j)       DSM
Financing. The Company shall have completed the DSM Financing on the terms set forth in the DSM Transaction Documents heretofore
provided to the Purchasers.


 


ARTICLE
7

OTHER AGREEMENTS OF THE PARTIES


 


7.1.           
Securities Laws Disclosure. The Company will file a Current Report on Form 8-K with the SEC describing the
terms of the Transaction Agreements (the “8-K Filing”) within the time required by the Exchange Act. Neither
the Company, its Subsidiaries nor the Purchasers shall issue any press releases or any other public statements with respect to
the transactions contemplated hereby without the prior consent of the other; provided, however, the Company or the Purchasers each
shall be entitled, without the prior approval of the other, to make any press release or other public disclosure with respect to
such transactions (i) in substantial conformity with the 8-K Filing and contemporaneously therewith and (ii) as is required by
applicable law and regulations.


 


7.2.           
Form D; Blue Sky Filings. The Company agrees to timely file a Form D with respect to the Securities
as required under Regulation D and to provide a copy thereof to the Purchasers (provided that the posting of the Form D on
the SEC’s EDGAR system shall be deemed delivery of the Form D for purposes of this Agreement). The Company shall take such
action as the Company shall reasonably determine is necessary in order to obtain exemption for, or to qualify the Securities for
sale to the Purchasers at the Closing under the applicable securities or “Blue Sky” laws of the states of the United
States, and shall provide evidence of such action promptly upon request of either Purchaser.


 



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7.3.           
Removal of Legends and Transfer Restrictions. The Company hereby covenants with the Purchasers to, no later
than three trading days following the delivery by either Purchaser to the Company of a legended certificate representing Securities
(endorsed or with stock powers attached, signatures guaranteed, and otherwise in form necessary to affect the reissuance and/or
transfer), in connection with the transfer or sale of all or a portion of the Securities pursuant to (1) an effective registration
statement that is effective at the time of such sale or transfer, (2) a transaction exempt from the registration requirements of
the Securities Act in which the Company receives an opinion of counsel reasonably satisfactory to the Company that the Securities
are freely transferable and that the legend is no longer required on such stock certificate, or (3) an exemption from registration
pursuant to SEC Rule 144, deliver or cause the Company’s transfer agent to deliver to the transferee of the Securities or
to such Purchaser, as applicable, a new certificate representing such Securities that is free from all restrictive and other legends.
The Company acknowledges that the remedy at law for a breach of its obligations under this Section 7.3 may be inadequate
and agrees, in the event of a breach or threatened breach by the Company of the provisions of this Section 7.3 with
respect to any Purchaser, the Purchaser shall be entitled, in addition to all other available remedies, to an order and/or injunction
restraining any breach and requiring immediate issuance and transfer, without the necessity of showing economic loss and without
any bond or other security being required.


 


7.4.           
Stockholder Approval.


 


(a)       Stockholders
Meeting. On or prior to the date of the Company’s 2018 Annual Meeting of Stockholders or, at either Purchaser’s
option, any date prior thereto upon at least ninety (90) days’ prior written notice, the Company shall hold a meeting of
stockholders of the Company (the “Stockholder Meeting”) for the purpose of voting upon the approval of resolutions
(the “Stockholder Resolutions”) with respect to the matters contemplated by the Stockholder Approval (as defined
below) (the date such approval is obtained, the “Stockholder Approval Date”), provided, however,
nothing herein shall prevent the Company from postponing or adjourning the Stockholder Meeting if (i) there are insufficient shares
of the Common Stock present or represented by a proxy at the Stockholder Meeting to conduct business at the Stockholder Meeting,
(ii) the Company is required to postpone or adjourn the Stockholder Meeting by applicable law or a request from the Commission
or its staff, or (iii) the Company determines in good faith (after consultation with outside legal counsel) that it is necessary
or appropriate to postpone or adjourn the Stockholder Meeting in order to give the stockholders of the Company sufficient time
to evaluate any information or disclosure that the Company has sent to the stockholders or otherwise made available to the stockholders
by issuing a press release, filing materials with the SEC or otherwise. The Company shall solicit from the stockholders of the
Company proxies in favor of the Stockholder Resolutions in accordance with applicable law, and shall submit the Stockholder Resolutions
for a vote of the Company’s stockholders at the Stockholder Meeting. The Company shall use commercially reasonable efforts
to secure the Stockholder Approval at the Stockholder Meeting. As used herein, “Stockholder Approval” means
such approval as may be required by the applicable rules and regulations of the Nasdaq Stock Market (or any successor entity) from
the stockholders of the Company with respect to the anti-dilution provisions of the Warrants.


 



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(b)       Company
Board Recommendation. Subject to the terms of this Section 7.4(b), the Board of Directors shall recommend that
the Company’s stockholders approve the Stockholder Resolutions in accordance with the applicable law (the “Company
Board Recommendation”). Neither the Board of Directors nor any committee thereof shall fail to make, withhold, withdraw,
amend or modify in a manner adverse to the Purchasers the Company Board Recommendation, unless the Board of Directors determines
in good faith (after consultation with outside legal counsel) that the failure to make such public statement would be a breach
of its fiduciary duties to the Company’s stockholders under applicable law (a “Company Board Recommendation Change”).
Notwithstanding the foregoing, at any time prior to the receipt of the Stockholder Approval, the Board of Directors may effect
a Company Board Recommendation Change if, as a result of an Intervening Event, the Board of Directors determines in good faith
(after consultation with outside legal counsel) that the failure to effect a Company Board Recommendation Change would be a breach
of its fiduciary duties to the Company’s stockholders under applicable law; provided that prior to effecting such
Company Board Recommendation Change, the Board of Directors shall give the Purchasers at least four Business Days advance notice
thereof (the “Notice Period”). For the purposes of this Section 7.4(b), an “Intervening Event”
means any material event or development or material change in circumstances with respect to the Company that (i) was unknown by
the Board of Directors as of, or prior to, the date hereof, or (ii) if known, the magnitude and consequences of which were not
known or foreseeable by the Board of Directors as of the date hereof.


 


(c)       Additional
Stockholder Meetings. If the Company does not obtain Stockholder Approval at the first meeting, the Company shall call a meeting
every four months thereafter to seek Stockholder Approval until the earlier of the date Stockholder Approval is obtained or the
Warrants are no longer outstanding.


 


7.5.           
Subsequent Equity Sales. The Company shall not, and shall use its commercially reasonable efforts to ensure
that no Affiliate of the Company shall, sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any
security (as defined in Section 2 of the Securities Act) that will be integrated with the offer or sale of the Securities
in a manner that would require the registration under the Securities Act of the sale of the Securities to the Purchasers, or that
will be integrated with the offer or sale of the Securities for purposes of the rules and regulations of any trading market such
that it would require stockholder approval prior to the closing of such other transaction unless stockholder approval is obtained
before the closing of such subsequent transaction; provided, however, that the foregoing shall not prohibit the issuance by the
Company of any securities in connection with the DSM Financing. Additionally, (i) unless Stockholder Approval has been obtained
and deemed effective, neither the Company nor any subsidiary shall make any issuance whatsoever of Common Stock, Common Stock Equivalents
or any other securities that would have triggered the anti-dilution protection in the Warrants (if the Stockholder Approval had
been obtained prior to such issuance) without the Purchasers’ prior written consent (which consent may be withheld, conditioned
or denied in the Purchaser’s sole and absolute discretion) and (ii) neither the Company nor any subsidiary shall make any
issuance whatsoever of Common Stock, Common Stock Equivalents or any other securities that would have triggered the anti-dilution
protection in the Warrants at an effective price per share less than $0.10 (as adjusted for any stock splits, stock dividends,
recapitalizations or the like). The Purchasers shall be entitled to obtain injunctive relief against the Company to preclude any
such issuance, which remedy shall be in addition to any right to collect damages.


 



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7.6.           
Listing. The Company shall promptly take any action required to maintain the listing of all of the Shares
and the Underlying Shares, once they have been issued, upon each national securities exchange and automated quotation system, if
any, upon which shares of Common Stock are then listed (subject to official notice of issuance) and shall maintain, so long as
any other shares of Common Stock shall be so listed, such listing of all Shares and Underlying Shares from time to time issuable
under the terms of the Transaction Agreements. The Company shall take all actions within its control to comply with the reporting
requirements of the Exchange Act and each applicable national securities exchange and automated quotation system on which the Common
Stock is listed. The Company shall make and keep public information available, as those terms are understood and defined in SEC
Rule 144, for so long as required in order to permit the resale of the Securities pursuant to SEC Rule 144 and to file period reports
with the SEC whether or not required to do so. The Company shall not take any action which would be reasonably expected to result
in the delisting or suspension of the Common Stock on The NASDAQ Stock Market.


 


7.7.           
Reservation of Common Stock. Following the date hereof, the Company will immediately reserve and continue
to keep available, at all times, free of preemptive or similar rights, a sufficient number of shares of Common Stock equal to,
as of any date, the maximum aggregate number of shares of Common Stock then issuable or potentially issuable in the future pursuant
to the Transaction Agreements, including, without limitation, any Underlying Shares issuable upon exercise in full of all Warrants
or conversion in full of all shares of Preferred Stock, ignoring any conversion or exercise limits set forth therein.


 


7.8.           
Voting Restriction. Each Purchaser hereby agrees not to vote any Underlying
Shares or Common Shares held by such Purchaser for or against the Stockholder Approval, whether at the Stockholder Meeting or at
any subsequent meeting of the Company’s stockholders with respect to any vote relating to the Stockholder Approval.


 


 


ARTICLE
8

MISCELLANEOUS


 


8.1.           
Survival. The representations, warranties and covenants contained herein shall survive the execution and delivery
of this Agreement and the sale of the Securities.


 


8.2.           
Indemnification.


 


(a)       Indemnification
of Purchasers. The Company agrees to indemnify and hold harmless the Purchasers and their respective Affiliates and their respective
directors, officers, trustees, members, managers, partners, employees and agents, and their respective successors and assigns (each,
a “Purchaser Party”), from and against any and all losses, obligations, claims, contingencies, damages, liabilities
and expenses (including without limitation reasonable attorney fees and disbursements and other expenses reasonably incurred in
connection with investigating, preparing or defending any action, claim or proceeding, pending or threatened and the costs of enforcement
thereof) (collectively, “Losses”) to which the Purchaser Party may become subject or suffer or incur as a result
of or relating to (a) any breach of any representation, warranty, covenant or agreement made by or to be performed on the part
of the Company under the Transaction Agreements or (b) any action instituted against the Purchaser Parties in any capacity, or
any of them or their respective Affiliates, by any stockholder of the Company who is not an Affiliate of such Purchaser Party,
with respect to any of the transactions contemplated by the Transaction Agreements (unless such action is based upon a breach of
the Purchaser Party’s representations, warranties or covenants under the Transaction Documents or any agreements or understanding
such Purchaser Party may have with any such stockholder or any violations by such Purchaser Party of state or federal securities
laws or any conduct by such Purchaser Party which constitutes fraud, gross negligence or willful misconduct). The Company agrees
to reimburse each Purchaser Party for all such Losses as they are incurred by such Purchaser Party.


 



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(b)       Conduct
of Indemnification Proceedings. Any Purchaser Party entitled to indemnification hereunder shall (i) give prompt notice to the
Company of any claim with respect to which it seeks indemnification and (ii) permit the Company to assume the defense of such claim
with counsel reasonably satisfactory to the indemnified party; provided that any Purchaser Party entitled to indemnification
hereunder shall have the right to employ separate counsel and to participate in the defense of such claim, but the fees and expenses
of such counsel shall be at the expense of such Purchaser Party unless (a) the Company has agreed to pay such fees or expenses,
or (b) the Company shall have failed after a reasonable period of time to assume the defense of such claim and employ counsel
reasonably satisfactory to such Purchaser Party or (c) in the reasonable judgment of any such Purchaser Party, based upon written
advice of its counsel, a conflict of interest exists between such Purchaser Party and the Company with respect to such claims (in
which case, if the Purchaser Party notifies the Company in writing that such Purchaser Party elects to employ separate counsel
at the expense of the Company, the Company shall not have the right to assume the defense of such claim on behalf of such Purchaser
Party); and provided, further, that the failure of any Purchaser Party to give notice as provided herein shall not
relieve the Company of its obligations hereunder, except to the extent that such failure to give notice shall materially adversely
affect the Company in the defense of any such claim or litigation. It is understood that the Company shall not, in connection with
any proceeding in the same jurisdiction, be liable for fees or expenses of more than one separate firm of attorneys at any time
for all such indemnified parties. The Company will not, except with the prior written consent of the Purchaser Party, consent to
entry of any judgment or enter into any settlement that does not include as an unconditional term thereof the giving by the claimant
or plaintiff to such Purchaser Party of a release from all liability in respect of such claim or litigation. No Purchaser Party
will, except with the consent of the Company, consent to entry of any judgment or enter into any settlement. The indemnity agreements
contained herein shall be in addition to any cause of action or similar right of any Purchaser Party against the Company or others
and any liabilities of the Company may be subject pursuant to law.


 


8.3.           
Assignment; Successors and Assigns. This Agreement may not be assigned by either party without the prior written
consent of the other party; provided, that this Agreement may be assigned by any Purchaser to the valid transferee of any
security purchased hereunder if such security remains a “restricted security” under the Securities Act. This Agreement
and all provisions thereof shall be binding upon, inure to the benefit of, and are enforceable by the parties hereto and their
respective successors and permitted assigns.


 



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8.4.           
Notices. All notices, requests, and other communications hereunder shall be in writing and will be deemed
to have been duly given and received (a) when personally delivered, (b) when sent by facsimile upon confirmation of receipt,
(c) one business day after the day on which the same has been delivered prepaid to a nationally recognized courier service,
or (d) five business days after the deposit in the United States mail, registered or certified, return receipt requested,
postage prepaid, in each case addressed to, as to the Company, Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, CA 94608,
Attn: General Counsel, facsimile number: (510) 740-7416, with a copy to Fenwick & West LLP, 801 California Street, Mountain
View, CA 94041, Attn: Dan Winnike, Esq., facsimile number: (650) 938-5200, and as to a Purchaser at the address and facsimile
number set forth below such Purchaser’s signature on the signature pages of this Agreement. Any party hereto from time to
time may change its address, facsimile number, or other information for the purpose of notices to that party by giving notice specifying
such change to the other parties hereto. Any Purchaser and the Company may each agree in writing to accept notices and other communications
to it hereunder by electronic communications pursuant to procedures reasonably approved by it; provided that approval of such procedures
may be limited to particular notices or communications.


 


8.5.           
Governing Law. All questions concerning the construction, validity, enforcement and interpretation of the
Transaction Agreements shall be governed by and construed and enforced in accordance with the internal laws of the State of New
York, without regard to the principles of conflicts of law thereof. Each party agrees that all legal proceedings concerning the
interpretations, enforcement and defense of the transactions contemplated by this Agreement and any other Transaction Agreements
(whether brought against a party hereto or its respective affiliates, directors, officers, shareholders, partners, members, employees
or agents) shall be commenced exclusively in the state and federal courts sitting in the City of New York. Each party hereby irrevocably
submits to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan for
the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein
(including with respect to the enforcement of any of the Transaction Agreements), and hereby irrevocably waives, and agrees not
to assert in any action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that
such action or proceeding is improper or is an inconvenient venue for such proceeding. Each party hereby irrevocably waives personal
service of process and consents to process being served in any such action or proceeding by mailing a copy thereof via registered
or certified mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices to it under
this Agreement and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing
contained herein shall be deemed to limit in any way any right to serve process in any other manner permitted by law. If any party
shall commence an action or proceeding to enforce any provisions of the Transaction Agreements, then, in addition to the obligations
of the Company under Section 8.2, the prevailing party in such action or pproceeding shall be reimbursed by the non- prevailing
party for its reasonable attorneys’ fees and other costs and expenses incurred with the investigation, preparation and prosecution
of such action or proceeding.


 



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8.6.           
Confidentiality. The Company and the Purchasers agree to use, and to use its reasonable best efforts to ensure
that its authorized representatives use the same degree of care as such party uses to protect its own confidential information
(but in no event less than reasonable care) to keep confidential the information provided to it pursuant to this Agreement, and
any other information furnished to it which the disclosing party identifies as being confidential or proprietary (so long as such
information is not in the public domain) or, under the circumstances surrounding disclosure, such party knows or has reason to
know should be treated as confidential (“Confidential Information”), unless otherwise required by law (provided
that a party shall, to the extent permitted by law, promptly notify the other party of any required disclosure and take reasonable
steps to minimize the extent of any such required disclosure); provided, however, that Confidential Information shall not include
information, that (i) was in the public domain prior to the time it was furnished to such recipient, (ii) is at the time of the
alleged breach (through no willful or improper action or inaction by such recipient) generally available to the public, (iii) was
rightfully disclosed to such recipient by a third party without restriction or (iv) as of the time of the alleged breach, had been
independently developed (as evidenced by written records) without any use of Confidential Information.


 


8.7.           
Severability. In the event that any provision of this Agreement or the application of any provision hereof
is declared to be illegal, invalid, or otherwise unenforceable by a court of competent jurisdiction, the remainder of this Agreement
shall not be affected except to the extent necessary to delete such illegal, invalid, or unenforceable provision unless that provision
held invalid shall substantially impair the benefits of the remaining portions of this Agreement.


 


8.8.           
Headings. The headings in this Agreement are for convenience of reference only and shall not constitute a
part of this Agreement, nor shall they affect its meaning, construction, or effect.


 


8.9.           
Entire Agreement. This Agreement embodies the entire understanding and agreement between the parties hereto
with respect to the subject matter hereof and supersedes all prior agreements and understandings relating to the subject matter
hereof.


 


8.10.       
Finder’s Fee. The Company agrees that it shall be responsible for the payment of any placement agent’s
fees, financial advisory fees, or brokers’ commissions (other than for Persons engaged by the Purchasers) relating to or
arising out of the transactions contemplated hereby. The Company shall pay, and hold the Purchasers harmless against, any liability,
loss or expense (including, without limitation, reasonable attorneys’ fees and out-of-pocket expenses) arising in connection
with any claim for any such fees or commissions.


 


8.11.       
Expenses. Each party will bear its own costs and expenses in connection with this Agreement; provided that
conditioned upon the Closing: (i) the Company will reimburse the Purchasers for their reasonable outside legal fees incurred in
connection with this Agreement and the transactions contemplated hereby in an amount not to exceed $75,000 in the aggregate, and
(ii) the Company shall reimburse the Purchasers for reasonable financing related fees and expenses incurred in connection with
the Purchasers’ funding of the Purchase Price in an amount not to exceed $50,000 in the aggregate.


 



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8.12.       
Further Assurances. The parties agree to execute and deliver all such further documents, agreements and instruments
and take such other and further action as may be necessary or appropriate to carry out the purposes and intent of this Agreement.


 


8.13.       
Counterparts. This Agreement may be executed in two or more counterparts, each of which shall constitute an
original, but all of which, when taken together, shall constitute but one instrument, and shall become effective when one or more
counterparts have been signed by each party hereto and delivered to the other party. Facsimile signatures shall be deemed originals
for all purposes hereunder.


 


8.14.       
WAIVER OF JURY TRIAL. IN ANY ACTION, SUIT, OR PROCEEDING IN ANY JURISDICTION BROUGHT BY ANY PARTY AGAINST ANY
OTHER PARTY, THE PARTIES EACH KNOWINGLY AND INTENTIONALLY, TO THE GREATEST EXTENT PERMITTED BY APPLICABLE LAW, HEREBY ABSOLUTELY,
UNCONDITIONALLY, IRREVOCABLY AND EXPRESSLY WAIVES FOREVER TRIAL BY JURY.


 


 


[Signature pages follows] 


 



    28


     

    




This Securities Purchase Agreement is hereby
confirmed and accepted by the Company as of August 2, 2017.


 


	 	 	 
	 	AMYRIS, INC.
	 	 	 
	 	By:	
         /s/ John Melo

	 	Name: John Melo
	 	Title: President and CEO


 


 


 


 


[Signature Page to
Securities Purchase Agreement]






     


     

    

This Securities Purchase Agreement is hereby
confirmed and accepted by the Purchasers as of August 2, 2017.


 





	 	PURCHASERS: 
	 	 	 
	 	VIVO CAPITAL FUND VIII, L.P.
	 	 	 
	 	 	 
	 	By: 	/s/ Frank Kung
	 	Name: 	Frank Kung
	 	Title: 	Managing Member



 


	 	Common Shares: 	2,483,737
	 	Preferred Shares: 	2,672,758




	 	Shares subject to Cash Warrant:	 4,898,670






 





 


	 	VIVO SURPLUS FUNDS VIII, L.P.
	 	 	 
	 	 	 
	 	By: 	/s/ Frank Kung
	 	Name: 	Frank Kung
	 	Title: 	Managing Member



 


	 	Common Shares: 	 342,974
	 	Preferred Shares: 	 369,076




	 	Shares subject to Cash Warrant:	
676,448


 



 


	 	Address: 
	 	505 Hamilton Ave
	 	Suite 207
	 	Palo Alto, CA 94301




	 	Facsimile No: 	 
	 	E-mail Address: 	 




 


 


 






    [Signature Page to Securities Purchase Agreement]


     

    

Exhibit A


 


FORM OF CASH WARRANT


 


 


 


 


 






     


     

    


NEITHER THIS SECURITY NOR THE SECURITIES
FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION
OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES
ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES
ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES
ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS. THIS SECURITY AND THE SECURITIES ISSUABLE UPON EXERCISE OF THIS SECURITY
MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN SECURED BY SUCH SECURITIES


 


COMMON STOCK PURCHASE WARRANT


 


AMYRIS,
INC. 


 





	Warrant Shares: [______]	 Issue Date: August __, 2017



 





 


THIS COMMON STOCK PURCHASE
WARRANT (the “Warrant”) certifies that, for value received, [________] or its assigns (the “Holder”)
is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time after
the Issue Date (the “Initial Exercise Date”) and on or prior to the close of business on the five (5) year anniversary
of the Initial Exercise Date (the “Termination Date”) but not thereafter, to subscribe for and purchase from
Amyris, Inc., a Delaware corporation (the “Company”), up to [______] shares (as subject to adjustment hereunder,
the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall
be equal to the Exercise Price, as defined in Section 2(b).


 


Section 1.Definitions.
Capitalized terms used and not otherwise defined herein shall have the meanings set forth in that certain Securities Purchase Agreement
(the “Purchase Agreement”), dated August 2, 2017, between the Company, the Holder and the other investors party
thereto.


 


Section 2.Exercise.


 


a)                 
Exercise of Warrant. Exercise of the purchase rights represented by this Warrant may be made, in whole or in part,
at any time or times on or after the Initial Exercise Date and on or before the Termination Date by delivery to the Company of
a duly executed facsimile copy or PDF copy submitted by electronic (or e-mail attachment) of the Notice of Exercise in the form
annexed hereto (“Notice of Exercise”). Within the earlier of (i) three (3) Trading Days (as defined in Section
2(c) herein) and (ii) the number of Trading Days comprising the Standard Settlement Period (as defined in Section 2(d)(i) herein)
following the date of exercise as aforesaid, the Holder shall deliver the aggregate Exercise Price for the shares specified in
the applicable Notice of Exercise by wire transfer or cashier’s check drawn on a United States bank unless the cashless exercise
procedure specified in Section 2(c) below is specified in the applicable Notice of Exercise. No ink-original Notice of Exercise
shall be required, nor shall any medallion guarantee (or other type of guarantee or notarization) of any Notice of Exercise form
be required. Notwithstanding anything herein to the contrary, the Holder shall not be required to physically surrender this Warrant
to the Company until the Holder has purchased all of the Warrant Shares available hereunder and the Warrant has been exercised
in full, in which case, the Holder shall surrender this Warrant to the Company for cancellation within three (3) Trading Days of
the date the final Notice of Exercise is delivered to the Company. Partial exercises of this Warrant resulting in purchases of
a portion of the total number of Warrant Shares available hereunder shall have the effect of lowering the outstanding number of
Warrant Shares purchasable hereunder in an amount equal to the applicable number of Warrant Shares purchased. The Company shall
maintain records showing the number of Warrant Shares purchased and the date of such purchases. The Company shall deliver any objection
to any Notice of Exercise within one (1) Business Day of receipt of such notice. The Holder and any assignee, by acceptance
of this Warrant, acknowledge and agree that, by reason of the provisions of this paragraph, following the purchase of a portion
of the Warrant Shares hereunder, the number of Warrant Shares available for purchase hereunder at any given time may be less than
the amount stated on the face hereof.


 



    1


     

    




b)                 
Exercise Price. The exercise price per share of the Common Stock under this Warrant shall be $6.39, subject to adjustment
hereunder (the “Exercise Price”).


 


c)                 
Cashless Exercise. This Warrant may be exercised, in whole or in part, at any time or times on or after the Initial
Exercise Date and on or before the Termination Date at the election of the Holder (in such Holder’s sole discretion) by means
of a “cashless exercise” in which the Holder shall be entitled to receive a number of Warrant Shares equal to the quotient
obtained by dividing ((A-B) * (X)) by (A), where:


 


(A) = as applicable:
(i) the VWAP on the Trading Day immediately preceding the date of the applicable Notice of Exercise if such Notice of Exercise
is (1) both executed and delivered pursuant to Section 2(a) hereof on a day that is not a Trading Day or (2) both executed and
delivered pursuant to Section 2(a) hereof on a Trading Day prior to the opening of “regular trading hours” (as defined
in Rule 600(b)(64) of Regulation NMS promulgated under the federal securities laws) on such Trading Day, (ii) at the option of
the Holder, either (y) the VWAP on the Trading Day immediately preceding the date of the applicable Notice of Exercise or (z) the
Bid Price of the Common Stock on the principal Trading Market as reported by Bloomberg L.P. as of the time of the Holder’s
execution of the applicable Notice of Exercise if such Notice of Exercise is executed during “regular trading hours”
on a Trading Day and is delivered within two (2) hours thereafter pursuant to Section 2(a) hereof or (iii) the VWAP on the date
of the applicable Notice of Exercise if the date of such Notice of Exercise is a Trading Day and such Notice of Exercise is both
executed and delivered pursuant to Section 1(a) hereof after the close of “regular trading hours” on such Trading Day;


 



    2


     

    




(B) = the
Exercise Price of this Warrant, as adjusted hereunder; and


 


(X) =
the number of Warrant Shares that would be issuable upon exercise of this Warrant in accordance with the terms of this Warrant
if such exercise were by means of a cash exercise rather than a cashless exercise.


 


If Warrant
Shares are issued in such a cashless exercise, the parties acknowledge and agree that in accordance with Section 3(a)(9) of the
Securities Act, the Warrant Shares shall take on the characteristics of the Warrants being exercised, and the holding period of
the Warrant Shares being issued may be tacked on to the holding period of this Warrant.  The Company agrees not to take
any position contrary to this Section 2(c).


 


“Bid
Price” means, for any date, the price determined by the first of the following clauses that applies: (a) if the Common
Stock is then listed or quoted on a Trading Market, the bid price of the Common Stock for the time in question (or the nearest
preceding date) on the Trading Market on which the Common Stock is then listed or quoted as reported by Bloomberg L.P. (based on
a Trading Day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time)), (b)  if OTCQB or OTCQX is not a Trading
Market, the volume weighted average price of the Common Stock for such date (or the nearest preceding date) on OTCQB or OTCQX as
applicable, (c) if the Common Stock is not then listed or quoted for trading on OTCQB or OTCQX and if prices for the Common Stock
are then reported in the “Pink Sheets” published by OTC Markets Group, Inc. (or a similar organization or agency succeeding
to its functions of reporting prices), the most recent bid price per share of the Common Stock so reported, or (d) in all
other cases, the fair market value of a share of Common Stock as determined by an independent appraiser selected in good faith
by the Purchaser and reasonably acceptable to the Company, the fees and expenses of which shall be paid by the Company.


 


“VWAP”
means, for any date, the price determined by the first of the following clauses that applies: (a) if the Common Stock is then listed
or quoted on a Trading Market, the daily volume weighted average price of the Common Stock for such date (or the nearest preceding
date) on the Trading Market on which the Common Stock is then listed or quoted as reported by Bloomberg L.P. (based on a Trading
Day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time)), (b)  if OTCQB or OTCQX is not a Trading Market,
the volume weighted average price of the Common Stock for such date (or the nearest preceding date) on OTCQB or OTCQX as applicable,
(c) if the Common Stock is not then listed or quoted for trading on OTCQB or OTCQX and if prices for the Common Stock are then
reported in the “Pink Sheets” published by OTC Markets Group, Inc. (or a similar organization or agency succeeding
to its functions of reporting prices), the most recent bid price per share of the Common Stock so reported, or (d) in all
other cases, the fair market value of a share of Common Stock as determined by an independent appraiser selected in good faith
by the Purchaser and reasonably acceptable to the Company, the fees and expenses of which shall be paid by the Company.


 



    3


     

    




“Trading
Day” means a day on which the principal Trading Market is open for trading.


 


“Trading
Market” means any of the following markets or exchanges on which the Common Stock is listed or quoted for trading on
the date in question: the NYSE MKT, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New
York Stock Exchange, OTCQB or OTCQX (or any successors to any of the foregoing).


 


Notwithstanding
anything herein to the contrary, on the Termination Date, this Warrant shall be automatically exercised via cashless exercise pursuant
to this Section 2(c).


 


 d)                  
Mechanics of Exercise.




 


i.           
Delivery of Warrant Shares Upon Exercise. Warrant Shares purchased hereunder shall be transmitted by the Transfer
Agent to the Holder by crediting the account of the Holder’s or its designee’s balance account with The Depository
Trust Company through its Deposit or Withdrawal at Custodian system (“DWAC”) if the Company is then a participant
in such system and either (A) there is an effective registration statement permitting the issuance of the Warrant Shares to or
resale of the Warrant Shares by the Holder or (B) the Warrant Shares are eligible for resale by the Holder without volume or manner-of-sale
limitations pursuant to Rule 144, and otherwise by physical delivery of a certificate, registered in the Company’s share
register in the name of the Holder or its designee, for the number of Warrant Shares to which the Holder is entitled pursuant to
such exercise to the address specified by the Holder in the Notice of Exercise by the date that is the earlier of (i) the earlier
of (A) three (3) Trading Days after the delivery to the Company of the Notice of Exercise and (B) one (1) Trading Day after delivery
of the aggregate Exercise Price to the Company and (ii) the number of Trading Days comprising the Standard Settlement Period after
the delivery to the Company of the Notice of Exercise (such date, the “Warrant Share Delivery Date”). Upon delivery
of the Notice of Exercise, the Holder shall be deemed for all corporate purposes to have become the holder of record of the Warrant
Shares with respect to which this Warrant has been exercised, irrespective of the date of delivery of the Warrant Shares, provided
that payment of the aggregate Exercise Price (other than in the case of a cashless exercise) is received within the earlier of
(i) three Trading Days and (ii) the number of Trading Days comprising the Standard Settlement Period following delivery of the
Notice of Exercise. If the Company fails for any reason to deliver to the Holder the Warrant Shares subject to a Notice of Exercise
by the Warrant Share Delivery Date, the Company shall pay to the Holder, in cash, as liquidated damages and not as a penalty, for
each $1,000 of Warrant Shares subject to such exercise (based on the VWAP of the Common Stock on the date of the applicable Notice
of Exercise), $10 per Trading Day (increasing to $20 per Trading Day on the fifth Trading Day after such liquidated damages begin
to accrue) for each Trading Day commencing one Trading Day after such Warrant Share Delivery Date until such Warrant Shares are
delivered or Holder rescinds such exercise. The Company agrees to maintain a transfer agent that is a participant in the FAST program
so long as this Warrant remains outstanding and exercisable. As used herein, “Standard Settlement Period” means
the standard settlement period, expressed in a number of Trading Days, on the Company’s primary Trading Market with respect
to the Common Stock as in effect on the date of delivery of the Notice of Exercise.


 



    4


     

    




ii.                    
Delivery of New Warrants Upon Exercise. If this Warrant shall have been exercised in part, the Company shall, at
the request of a Holder and upon surrender of this Warrant certificate, at the time of delivery of the Warrant Shares, deliver
to the Holder a new Warrant evidencing the rights of the Holder to purchase the unpurchased Warrant Shares called for by this Warrant,
which new Warrant shall in all other respects be identical with this Warrant.


 


iii.                 
Rescission Rights. If the Company fails to cause the Transfer Agent to transmit to the Holder the Warrant Shares
pursuant to Section 2(d)(i) by the Warrant Share Delivery Date, then the Holder will have the right to rescind such exercise.


 


iv.                 
Compensation for Buy-In on Failure to Timely Deliver Warrant Shares. In addition to any other rights available to
the Holder, if the Company fails to cause the Transfer Agent to transmit to the Holder the Warrant Shares in accordance with the
provisions of Section 2(d)(i) above pursuant to an exercise on or before the Warrant Share Delivery Date, and if after such date
the Holder is required by its broker to purchase (in an open market transaction or otherwise) or the Holder’s brokerage firm
otherwise purchases, shares of Common Stock to deliver in satisfaction of a sale by the Holder of the Warrant Shares which the
Holder anticipated receiving upon such exercise (a “Buy-In”), then the Company shall (A) pay in cash to the
Holder the amount, if any, by which (x) the Holder’s total purchase price (including brokerage commissions, if any) for the
shares of Common Stock so purchased exceeds (y) the amount obtained by multiplying (1) the number of Warrant Shares that the Company
was required to deliver to the Holder in connection with the exercise at issue times (2) the price at which the sell order giving
rise to such purchase obligation was executed, and (B) at the option of the Holder, either reinstate the portion of the Warrant
and equivalent number of Warrant Shares for which such exercise was not honored (in which case such exercise shall be deemed rescinded)
or deliver to the Holder the number of shares of Common Stock that would have been issued had the Company timely complied with
its exercise and delivery obligations hereunder. For example, if the Holder purchases Common Stock having a total purchase price
of $11,000 to cover a Buy-In with respect to an attempted exercise of shares of Common Stock with an aggregate sale price giving
rise to such purchase obligation of $10,000, under clause (A) of the immediately preceding sentence the Company shall be required
to pay the Holder $1,000. The Holder shall provide the Company written notice indicating the amounts payable to the Holder in respect
of the Buy-In and, upon request of the Company, evidence of the amount of such loss. Nothing herein shall limit a Holder’s
right to pursue any other remedies available to it hereunder, at law or in equity including, without limitation, a decree of specific
performance and/or injunctive relief with respect to the Company’s failure to timely deliver shares of Common Stock upon
exercise of the Warrant as required pursuant to the terms hereof


 



    5


     

    




v.                 
No Fractional Shares or Scrip. No fractional shares or scrip representing fractional shares shall be issued upon
the exercise of this Warrant. As to any fraction of a share which the Holder would otherwise be entitled to purchase upon such
exercise, the Company shall, at its election, either pay a cash adjustment in respect of such final fraction in an amount equal
to such fraction multiplied by the Exercise Price or round up to the next whole share.


 


vi.                 
Charges, Taxes and Expenses. Issuance of Warrant Shares shall be made without charge to the Holder for any issue
or transfer tax or other incidental expense in respect of the issuance of such Warrant Shares, all of which taxes and expenses
shall be paid by the Company, and such Warrant Shares shall be issued in the name of the Holder or in such name or names as may
be directed by the Holder; provided, however, that in the event that Warrant Shares are to be issued in a name other
than the name of the Holder, this Warrant when surrendered for exercise shall be accompanied by the Assignment Form attached hereto
duly executed by the Holder and the Company may require, as a condition thereto, the payment of a sum sufficient to reimburse it
for any transfer tax incidental thereto. The Company shall pay all Transfer Agent fees required for same-day processing of any
Notice of Exercise and all fees to the Depository Trust Company (or another established clearing corporation performing similar
functions) required for same-day electronic delivery of the Warrant Shares.


 



    6


     

    




vii.                 
Closing of Books. The Company will not close its stockholder books or records in any manner which prevents the timely
exercise of this Warrant, pursuant to the terms hereof.


 


e)       Holder’s
Exercise Limitations. Notwithstanding anything to the contrary contained herein, the Company shall not effect any exercise
of this Warrant, and a Holder shall not have the right to exercise any portion of this Warrant, pursuant to Section 2 or otherwise,
to the extent that after giving effect to such issuance after exercise as set forth on the applicable Notice of Exercise, the Holder
(together with the Holder’s Affiliates, and any other Persons acting as a group together with the Holder or any of the Holder’s
Affiliates (such Persons, “Attribution Parties”)), would beneficially own in excess of the Beneficial Ownership
Limitation (as defined below).  For purposes of the foregoing sentence, the number of shares of Common Stock beneficially
owned by the Holder and its Affiliates and Attribution Parties shall include the number of shares of Common Stock issuable upon
exercise of this Warrant with respect to which such determination is being made, but shall exclude the number of shares of Common
Stock which would be issuable upon (i) exercise of the remaining, nonexercised portion of this Warrant beneficially owned by the
Holder or any of its Affiliates or Attribution Parties and (ii) exercise or conversion of the unexercised or nonconverted portion
of any other securities of the Company (including, without limitation, any other Common Stock Equivalents (as defined below)) subject
to a limitation on conversion or exercise analogous to the limitation contained herein beneficially owned by the Holder or any
of its Affiliates or Attribution Parties.  Except as set forth in the preceding sentence, for purposes of this Section 2(e),
beneficial ownership shall be calculated in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated
thereunder, it being acknowledged by the Holder that the Company is not representing to the Holder that such calculation is in
compliance with Section 13(d) of the Exchange Act and the Holder is solely responsible for any schedules required to be filed in
accordance therewith. To the extent that the limitation contained in this Section 2(e) applies, the determination of whether this
Warrant is exercisable (in relation to other securities owned by the Holder together with any Affiliates and Attribution Parties)
and of which portion of this Warrant is exercisable shall be in the sole discretion of the Holder, and the submission of a Notice
of Exercise shall be deemed to be the Holder’s determination of whether this Warrant is exercisable (in relation to other
securities owned by the Holder together with any Affiliates and Attribution Parties) and of which portion of this Warrant is exercisable,
in each case subject to the Beneficial Ownership Limitation, and the Company shall have no obligation to verify or confirm the
accuracy of such determination. In addition, a determination as to any group status as contemplated above shall be determined in
accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder. For purposes of this Section
2(e), in determining the number of outstanding shares of Common Stock, a Holder may rely on the number of outstanding shares of
Common Stock as reflected in (A) the Company’s most recent periodic or annual report filed with the Commission, as the case
may be, (B) a more recent public announcement by the Company or (C) a more recent written notice by the Company or the Transfer
Agent setting forth the number of shares of Common Stock outstanding.  Upon the written or oral request of a Holder, the Company
shall within two Trading Days confirm orally and in writing to the Holder the number of shares of Common Stock then outstanding. 
In any case, the number of outstanding shares of Common Stock shall be determined after giving effect to the conversion or exercise
of securities of the Company, including this Warrant, by the Holder or its Affiliates or Attribution Parties since the date as
of which such number of outstanding shares of Common Stock was reported. The “Beneficial Ownership Limitation”
shall be 9.99% of the number of shares of the Common Stock outstanding immediately after giving effect to the issuance of shares
of Common Stock issuable upon exercise of this Warrant. The Holder, upon notice to the Company, may waive the Beneficial Ownership
Limitation provisions of this Section 2(e), provided that such waiver (i) will not be effective until the 61st day after
such notice is delivered to the Company, and (ii) will not be effective to the extent such waiver would require the prior approval
of the Company’s stockholders, unless such approval has been obtained. If such stockholder approval is required and has not
been obtained, the Corporation shall use its commercially reasonable efforts to timely obtain such stockholder approval. The provisions
of this paragraph shall be construed and implemented in a manner otherwise than in strict conformity with the terms of this Section
2(e) to correct this paragraph (or any portion hereof) which may be defective or inconsistent with the intended Beneficial Ownership
Limitation herein contained or to make changes or supplements necessary or desirable to properly give effect to such limitation.
The limitations contained in this paragraph shall apply to a successor holder of this Warrant. “Common Stock Equivalents”
means any securities of the Company or its subsidiaries which would entitle the holder thereof to acquire at any time Common Stock,
including, without limitation, any debt, preferred stock, right, option, warrant or other instrument that is at any time convertible
into, or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Common Stock.


 



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Section 3.Certain
Adjustments.


 


a)     
Stock Dividends and Splits. If the Company, at any time while this Warrant is outstanding: (i) pays a stock dividend
or otherwise makes a distribution or distributions on shares of its Common Stock or any other equity or equity equivalent securities
payable in shares of Common Stock (which, for avoidance of doubt, shall not include any shares of Common Stock issued by the Company
upon exercise of this Warrant), (ii) subdivides outstanding shares of Common Stock into a larger number of shares, (iii) combines
(including by way of reverse stock split) outstanding shares of Common Stock into a smaller number of shares or (iv) issues by
reclassification of shares of the Common Stock any shares of capital stock of the Company, then in each case the Exercise Price
shall be multiplied by a fraction of which the numerator shall be the number of shares of Common Stock (excluding treasury shares,
if any) outstanding immediately before such event and of which the denominator shall be the number of shares of Common Stock outstanding
immediately after such event, and the number of shares issuable upon exercise of this Warrant shall be proportionately adjusted
such that the aggregate Exercise Price of this Warrant shall remain unchanged. Any adjustment made pursuant to this Section 3(a)
shall become effective immediately after the record date for the determination of stockholders entitled to receive such dividend
or distribution and shall become effective immediately after the effective date in the case of a subdivision, combination or re-classification.


 



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b)     
Subsequent Equity Sales. If the Company or any Subsidiary thereof, as applicable, during the period ending three
(3) years from the Issue Date, and while this Warrant is outstanding, shall sell or grant any option to purchase, or sell or grant
any right to reprice, or otherwise dispose of or issue (or announce any offer, sale, grant or any option to purchase or other disposition)
any Common Stock or Common Stock Equivalents, at an effective price per share less than the Exercise Price then in effect (such
lower price, the “Base Share Price” and such issuance, a “Dilutive Issuance”) (it being understood
and agreed that if the holder of the Common Stock or Common Stock Equivalents so issued shall at any time, whether by operation
of purchase price adjustments, reset provisions, floating conversion, exercise or exchange prices or otherwise, or due to warrants,
options or rights per share which are issued in connection with such issuance, be entitled to receive shares of Common Stock at
an effective price per share that is less than the Exercise Price, such issuance shall be deemed to have occurred for less than
the Exercise Price on such date of the Dilutive Issuance at such effective price) then the Exercise Price shall be reduced and
only reduced to the Base Share Price. Such adjustment shall be made whenever such Common Stock or Common Stock Equivalents are
issued. Notwithstanding the foregoing, no adjustments shall be made, paid or issued under this Section 3(b) (i) in respect of an
Exempt Issuance (as defined below), or (ii) until such time as the Company has obtained the Stockholder Approval; provided, however,
that any adjustments under this Section 3(b) that would have occurred but for the Company’s failure to obtain the Stockholder
Approval shall be deemed effective immediately after such date that the Stockholder Approval is obtained. The Company shall notify
the Holder, in writing, no later than the Trading Day following the issuance or deemed issuance of any Common Stock or Common Stock
Equivalents subject to this Section 3(b), indicating therein the applicable issuance price, or applicable reset price, exchange
price, conversion price and other pricing terms (such notice, the “Dilutive Issuance Notice”). For purposes of clarification,
whether or not the Company provides a Dilutive Issuance Notice pursuant to this Section 3(b), upon the occurrence of any Dilutive
Issuance, the Holder is entitled to receive a number of Warrant Shares based upon the Base Share Price regardless of whether the
Holder accurately refers to the Base Share Price in the Notice of Exercise. “Exempt Issuance” means the issuance
of (a) shares of Common Stock or options to employees, officers or directors of the Company pursuant to any stock or option plan
or employee stock purchase plan duly adopted for such purpose, by a majority of the non-employee members of the Board of Directors
or a majority of the members of a committee of non-employee directors established for such purpose for services rendered to the
Company, (b) securities upon the exercise or exchange of or conversion of any Securities issued under the Purchase Agreement and/or
other securities exercisable or exchangeable for or convertible into shares of Common Stock issued and outstanding, or committed
for issuance, or as to which a dilution adjustment may be triggered, or the payment of interest or principal in shares of Common
Stock on securities which so provide, outstanding or committed for issuance on the date of the Purchase Agreement, provided that
such securities have not been amended since the date of the Purchase Agreement to increase the number of such securities or to
decrease the exercise price, exchange price or conversion price of such securities (other than in connection with stock splits
or combinations or adjustments pursuant to anti-dilution provisions existing on the date hereof) or to extend the term of such
securities, (c) securities issued pursuant to acquisitions or strategic transactions approved by a majority of the disinterested
directors of the Company, provided that any such issuance shall only be to a Person (or to the equityholders of a Person) which
is, itself or through its subsidiaries, an operating company or an owner of an asset in a business synergistic with the business
of the Company as determined in good faith by the Board of Directors and shall provide to the Company additional benefits in addition
to the investment of funds, but shall not include a transaction in which the Company is issuing securities primarily for the purpose
of raising capital or to an entity whose primary business is investing in securities, and (d) any securities issued to DSM International
B.V. or its affiliates in connection with the DSM Financing (as defined in the Purchase Agreement).


 



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c)     
Subsequent Rights Offerings. In addition to any adjustments pursuant to Section 3(a) above, if at any time subsequent
to the Issue Date of this Warrant but prior to the date the Company obtains the Stockholder Approval the Company grants, issues
or sells any Common Stock Equivalents or rights to purchase stock, warrants, securities or other property pro rata to the record
holders of any class of shares of Common Stock (the “Purchase Rights”), then the Holder will be entitled to
acquire, upon the terms applicable to such Purchase Rights, the aggregate Purchase Rights which the Holder could have acquired
if the Holder had held the number of shares of Common Stock acquirable upon complete exercise of this Warrant (without regard to
any limitations on exercise hereof, including without limitation, the Beneficial Ownership Limitation) immediately before the date
on which a record is taken for the grant, issuance or sale of such Purchase Rights, or, if no such record is taken, the date as
of which the record holders of shares of Common Stock are to be determined for the grant, issue or sale of such Purchase Rights
(provided, however, to the extent that the Holder’s right to participate in any such Purchase Right would result in the Holder
exceeding the Beneficial Ownership Limitation and the Beneficial Ownership Limitation is not waived by the Holder, then the Holder
shall not be entitled to participate in such Purchase Right to such extent (or beneficial ownership of such shares of Common Stock
as a result of such Purchase Right to such extent) and such Purchase Right to such extent shall be held in abeyance for the Holder
until such time, if ever, as its right thereto would not result in the Holder exceeding the Beneficial Ownership Limitation).


 


d)    
Pro Rata Distributions. During such time as this Warrant is outstanding, if the Company shall declare or make any
dividend or other distribution of its assets (or rights to acquire its assets) to holders of shares of Common Stock, by way of
return of capital or otherwise (including, without limitation, any distribution of cash, stock or other securities, property or
options by way of a dividend, spin off, reclassification, corporate rearrangement, scheme of arrangement or other similar transaction,
but excluding any dividend that results in adjustment to the Conversion Price pursuant to Section 3(a) above) (a “Distribution”),
at any time after the issuance of this Warrant, then, in each such case, the Holder shall be entitled to participate in such Distribution
to the same extent that the Holder would have participated therein if the Holder had held the number of shares of Common Stock
acquirable upon complete exercise of this Warrant (without regard to any limitations on exercise hereof, including without limitation,
the Beneficial Ownership Limitation) immediately before the date of which a record is taken for such Distribution, or, if no such
record is taken, the date as of which the record holders of shares of Common Stock are to be determined for the participation in
such Distribution (provided, however, to the extent that the Holder's right to participate in any such Distribution
would result in the Holder exceeding the Beneficial Ownership Limitation and the Beneficial Ownership Limitation is not waived
by the Holder, then the Holder shall not be entitled to participate in such Distribution to such extent (or in the beneficial ownership
of any shares of Common Stock as a result of such Distribution to such extent) and the portion of such Distribution shall be held
in abeyance for the benefit of the Holder until such time, if ever, as its right thereto would not result in the Holder exceeding
the Beneficial Ownership Limitation).


 



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e)     
Fundamental Transaction. If, at any time while this Warrant is outstanding, (i) the Company, directly or indirectly,
in one or more related transactions effects any merger or consolidation of the Company with or into another Person, (ii) the Company,
directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other disposition of all or substantially
all of its assets in one or a series of related transactions, (iii) any, direct or indirect, purchase offer, tender offer or exchange
offer (whether by the Company or another Person) is completed pursuant to which holders of Common Stock are permitted to sell,
tender or exchange their shares for other securities, cash or property and has been accepted by the holders of 50% or more of the
outstanding Common Stock, (iv) the Company, directly or indirectly, in one or more related transactions effects any reclassification,
reorganization or recapitalization of the Common Stock or any compulsory share exchange pursuant to which the Common Stock is effectively
converted into or exchanged for other securities, cash or property, or (v) the Company, directly or indirectly, in one or more
related transactions consummates a stock or share purchase agreement or other business combination (including, without limitation,
a reorganization, recapitalization, spin-off or scheme of arrangement) with another Person or group of Persons whereby such other
Person or group acquires more than 50% of the outstanding shares of Common Stock (not including any shares of Common Stock held
by the other Person or other Persons making or party to, or associated or affiliated with the other Persons making or party to,
such stock or share purchase agreement or other business combination) (each a “Fundamental Transaction”), then,
the Holder shall have the right to receive, for each Warrant Share that would have been issuable upon such exercise immediately
prior to the occurrence of such Fundamental Transaction (as if the exercise of the Warrant occurred immediately prior to the occurrence
of such Fundamental Transaction), at the option of the Holder (without regard to any limitation in Section 2(e) on the exercise
of this Warrant), the number of shares of common stock of the successor or acquiring corporation or shares of Common Stock of the
Company, if it is the surviving corporation, and any additional consideration (the “Alternate Consideration”)
receivable as a result of such Fundamental Transaction by a holder of the number of shares of Common Stock for which this Warrant
is exercisable immediately prior to such Fundamental Transaction (without regard to any limitation in Section 2(e) on the exercise
of this Warrant). For purposes of any such exercise, the determination of the Exercise Price shall be appropriately adjusted to
apply to such Alternate Consideration based on the amount of Alternate Consideration issuable in respect of one share of Common
Stock in such Fundamental Transaction, and the Company shall apportion the Exercise Price among the Alternate Consideration in
a reasonable manner reflecting the relative value of any different components of the Alternate Consideration. If holders of Common
Stock are given any choice as to the securities, cash or property to be received in a Fundamental Transaction, then the Holder
shall be given the same choice as to the Alternate Consideration it receives upon any exercise of this Warrant following such Fundamental
Transaction.


 



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f)      
Calculations. All calculations under this Section 3 shall be made to the nearest cent or the nearest 1/100th of a
share, as the case may be. For purposes of this Section 3, the number of shares of Common Stock deemed to be issued and outstanding
as of a given date shall be the sum of the number of shares of Common Stock (excluding treasury shares, if any) issued and outstanding.


 


g)     
Notice to Holder.


 


i.     
Adjustment to Exercise Price. Whenever the Exercise Price is adjusted pursuant to any provision of this Section 3,
the Company shall within two (2) Trading Days deliver to the Holder by facsimile or email a notice setting forth the Exercise Price
after such adjustment and any resulting adjustment to the number of Warrant Shares and setting forth a brief statement of the facts
requiring such adjustment.


 


ii.     
Notice to Allow Exercise by Holder. If (A) the Company shall declare a dividend (or any other distribution in whatever
form) on the Common Stock, (B) the Company shall declare a special nonrecurring cash dividend on or a redemption of the Common
Stock, (C) the Company shall authorize the granting to all holders of the Common Stock rights or warrants to subscribe for or purchase
any shares of capital stock of any class or of any rights, (D) the approval of any stockholders of the Company shall be required
in connection with any reclassification of the Common Stock, any consolidation or merger to which the Company is a party, any sale
or transfer of all or substantially all of the assets of the Company, or any compulsory share exchange whereby the Common Stock
is converted into other securities, cash or property, or (E) the Company shall authorize the voluntary or involuntary dissolution,
liquidation or winding up of the affairs of the Company, then, in each case, the Company shall cause to be delivered by facsimile
or email to the Holder at its last facsimile number or email address as it shall appear upon the Warrant Register of the Company,
at least 20 calendar days prior to the applicable record or effective date hereinafter specified, a notice stating (x) the date
on which a record is to be taken for the purpose of such dividend, distribution, redemption, rights or warrants, or if a record
is not to be taken, the date as of which the holders of the Common Stock of record to be entitled to such dividend, distributions,
redemption, rights or warrants are to be determined or (y) the date on which such reclassification, consolidation, merger, sale,
transfer or share exchange is expected to become effective or close, and the date as of which it is expected that holders of the
Common Stock of record shall be entitled to exchange their shares of the Common Stock for securities, cash or other property deliverable
upon such reclassification, consolidation, merger, sale, transfer or share exchange; provided that the failure to deliver such
notice or any defect therein or in the delivery thereof shall not affect the validity of the corporate action required to be specified
in such notice. To the extent that any notice provided in this Warrant constitutes, or contains, material, non-public information
regarding the Company or any of the Subsidiaries, the Company shall simultaneously file such notice with the Commission pursuant
to a Current Report on Form 8-K. The Holder shall remain entitled to exercise this Warrant during the period commencing on the
date of such notice to the effective date of the event triggering such notice except as may otherwise be expressly set forth herein.


 



    12


     

    




Section 4.Transfer
of Warrant.


 


a)     
Transferability. Subject to compliance with any applicable securities laws and the conditions set forth in Section
4(d) hereof and to the provisions of Section 4 and 7.3 of the Purchase Agreement, this Warrant and all rights hereunder (including,
without limitation, any registration rights) are transferable, in whole or in part, upon surrender of this Warrant at the principal
office of the Company or its designated agent, together with a written assignment of this Warrant substantially in the form attached
hereto duly executed by the Holder or its agent or attorney and funds sufficient to pay any transfer taxes payable upon the making
of such transfer. Upon such surrender and, if required, such payment, the Company shall execute and deliver a new Warrant or Warrants
in the name of the assignee or assignees, as applicable, and in the denomination or denominations specified in such instrument
of assignment, and shall issue to the assignor a new Warrant evidencing the portion of this Warrant not so assigned, and this Warrant
shall promptly be cancelled. Notwithstanding anything herein to the contrary, the Holder shall not be required to physically surrender
this Warrant to the Company unless the Holder has assigned this Warrant in full, in which case, the Holder shall surrender this
Warrant to the Company within three (3) Trading Days of the date the Holder delivers an assignment form to the Company assigning
this Warrant full. The Warrant, if properly assigned in accordance herewith, may be exercised by a new holder for the purchase
of Warrant Shares without having a new Warrant issued.


 



    13


     

    




b)     
New Warrants. This Warrant may be divided or combined with other Warrants upon presentation hereof at the aforesaid
office of the Company, together with a written notice specifying the names and denominations in which new Warrants are to be issued,
signed by the Holder or its agent or attorney. Subject to compliance with Section 4(a), as to any transfer which may be involved
in such division or combination, the Company shall execute and deliver a new Warrant or Warrants in exchange for the Warrant or
Warrants to be divided or combined in accordance with such notice. All Warrants issued on transfers or exchanges shall be dated
the original issue date and shall be identical with this Warrant except as to the number of Warrant Shares issuable pursuant thereto.


 


c)     
Warrant Register. The Company shall register this Warrant, upon records to be maintained by the Company for that
purpose (the “Warrant Register”), in the name of the record Holder hereof from time to time. The Company may
deem and treat the registered Holder of this Warrant as the absolute owner hereof for the purpose of any exercise hereof or any
distribution to the Holder, and for all other purposes, absent actual notice to the contrary.


 


d)    
Transfer Restrictions. If, at the time of the surrender of this Warrant in connection with any transfer of this Warrant,
the transfer of this Warrant shall not be either (i) registered pursuant to an effective registration statement under the Securities
Act and under applicable state securities or blue sky laws or (ii) eligible for resale without volume or manner-of-sale restrictions
or current public information requirements pursuant to Rule 144, the Company may require, as a condition of allowing such transfer,
that the Holder or transferee of this Warrant, as the case may be, comply with the provisions of Section 8.3 of the Purchase Agreement.


 


e)     
Representation by the Holder. The Holder, by the acceptance hereof, represents and warrants that it is acquiring
this Warrant and, upon any exercise hereof, will acquire the Warrant Shares issuable upon such exercise, for its own account and
not with a view to or for distributing or reselling such Warrant Shares or any part thereof in violation of the Securities Act
or any applicable state securities law, except pursuant to sales registered or exempted under the Securities Act.


 


Section 5.Miscellaneous.


 


a)     
No Rights as Stockholder Until Exercise. This Warrant does not entitle the Holder to any voting rights, dividends
or other rights as a stockholder of the Company prior to the exercise hereof as set forth in Section 2(d)(i), except as expressly
set forth in Section 3.


 


b)     
Loss, Theft, Destruction or Mutilation of Warrant. The Company covenants that upon receipt by the Company of evidence
reasonably satisfactory to it of the loss, theft, destruction or mutilation of this Warrant or any stock certificate relating to
the Warrant Shares, and in case of loss, theft or destruction, of indemnity or security reasonably satisfactory to it (which, in
the case of the Warrant, shall not include the posting of any bond), and upon surrender and cancellation of such Warrant or stock
certificate, if mutilated, the Company will make and deliver a new Warrant or stock certificate of like tenor and dated as of such
cancellation, in lieu of such Warrant or stock certificate.


 



    14


     

    




c)     
Saturdays, Sundays, Holidays, etc. If the last or appointed day for the taking of any action or the expiration of
any right required or granted herein shall not be a Business Day, then, such action may be taken or such right may be exercised
on the next succeeding Business Day.


 


d)    
Authorized Shares.


 


During the period
the Warrant is outstanding from and after the Initial Exercise Date, the Company covenants that it will reserve from its authorized
and unissued Common Stock a sufficient number of shares to provide for the issuance of the Warrant Shares upon the exercise of
any purchase rights under this Warrant. The Company further covenants that its issuance of this Warrant shall constitute full authority
to its officers who are charged with the duty of issuing the necessary Warrant Shares upon the exercise of the purchase rights
under this Warrant. The Company will take all such reasonable action as may be necessary to assure that such Warrant Shares may
be issued as provided herein without violation of any applicable law or regulation, or of any requirements of the Trading Market
upon which the Common Stock may be listed. The Company covenants that all Warrant Shares which may be issued upon the exercise
of the purchase rights represented by this Warrant will, upon exercise of the purchase rights represented by this Warrant and payment
for such Warrant Shares in accordance herewith, be duly authorized, validly issued, fully paid and nonassessable and free from
all taxes, liens and charges created by the Company in respect of the issue thereof (other than taxes in respect of any transfer
occurring contemporaneously with such issue).


 


Except and
to the extent as waived or consented to by the Holder, the Company shall not by any action, including, without limitation, amending
its certificate of incorporation or through any reorganization, transfer of assets, consolidation, merger, dissolution, issue or
sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms of this
Warrant, but will at all times in good faith assist in the carrying out of all such terms and in the taking of all such actions
as may be necessary or appropriate to protect the rights of Holder as set forth in this Warrant against impairment. Without limiting
the generality of the foregoing, the Company will (i) not increase the par value of any Warrant Shares above the amount payable
therefor upon such exercise immediately prior to such increase in par value, (ii) take all such action as may be necessary or appropriate
in order that the Company may validly and legally issue fully paid and nonassessable Warrant Shares upon the exercise of this Warrant
and (iii) use commercially reasonable efforts to obtain all such authorizations, exemptions or consents from any public regulatory
body having jurisdiction thereof, as may be, necessary to enable the Company to perform its obligations under this Warrant.


 



    15


     

    




Before taking
any action which would result in an adjustment in the number of Warrant Shares for which this Warrant is exercisable or in the
Exercise Price, the Company shall obtain all such authorizations or exemptions thereof, or consents thereto, as may be necessary
from any public regulatory body or bodies having jurisdiction thereof.


 


e)     
Jurisdiction. All questions concerning the construction, validity, enforcement and interpretation of this Warrant
shall be determined in accordance with the provisions of the Purchase Agreement.


 


f)      
Restrictions. The Holder acknowledges that the Warrant Shares acquired upon the exercise of this Warrant, if not
registered and the Holder does not utilize cashless exercise, will have restrictions upon resale imposed by state and federal securities
laws.


 


g)     
Nonwaiver and Expenses. No course of dealing or any delay or failure to exercise any right hereunder on the part
of Holder shall operate as a waiver of such right or otherwise prejudice the Holder’s rights, powers or remedies, notwithstanding
the fact that all rights hereunder terminate on the Termination Date. If the Company willfully and knowingly fails to comply with
any provision of this Warrant, which results in any material damages to the Holder, the Company shall pay to the Holder such amounts
as shall be sufficient to cover any costs and expenses including, but not limited to, reasonable attorneys’ fees, including
those of appellate proceedings, incurred by the Holder in collecting any amounts due pursuant hereto or in otherwise enforcing
any of its rights, powers or remedies hereunder.


 


h)     
Notices. Any notice, request or other document required or permitted to be given or delivered to the Holder by the
Company shall be delivered in accordance with the notice provisions of the Purchase Agreement.


 


i)       
Limitation of Liability. No provision hereof, in the absence of any affirmative action by the Holder to exercise
this Warrant to purchase Warrant Shares, and no enumeration herein of the rights or privileges of the Holder, shall give rise to
any liability of the Holder for the purchase price of any Common Stock or as a stockholder of the Company, whether such liability
is asserted by the Company or by creditors of the Company.


 


j)       
Remedies. The Holder, in addition to being entitled to exercise all rights granted by law, including recovery of
damages, will be entitled to specific performance of its rights under this Warrant. The Company agrees that monetary damages would
not be adequate compensation for any loss incurred by reason of a breach by it of the provisions of this Warrant and hereby agrees
to waive and not to assert the defense in any action for specific performance that a remedy at law would be adequate.


 



    16


     

    




k)     
Successors and Assigns. Subject to applicable securities laws, this Warrant and the rights and obligations evidenced
hereby shall inure to the benefit of and be binding upon the successors and permitted assigns of the Company and the successors
and permitted assigns of Holder. The provisions of this Warrant are intended to be for the benefit of any Holder from time to time
of this Warrant and shall be enforceable by the Holder or holder of Warrant Shares.


 


l)       
Amendment. This Warrant may be modified or amended or the provisions hereof waived with the written consent of the
Company and the Holder.


 


m)   
Severability. Wherever possible, each provision of this Warrant shall be interpreted in such manner as to be effective
and valid under applicable law, but if any provision of this Warrant shall be prohibited by or invalid under applicable law, such
provision shall be ineffective to the extent of such prohibition or invalidity, without invalidating the remainder of such provisions
or the remaining provisions of this Warrant.


 


n)     
Headings. The headings used in this Warrant are for the convenience of reference only and shall not, for any purpose,
be deemed a part of this Warrant.


 


 


********************


 


 


(Signature Page Follows)


 


 


 



    17


     

    




IN WITNESS WHEREOF, the
Company has caused this Warrant to be executed by its officer thereunto duly authorized as of the date first above indicated.


 


 


 


 

	 	AMYRIS, INC.



	 	 
	 	 
	 	By:	
         

	 	 	Name:
	 	 	Title:


 


 






    18


     

    

NOTICE OF EXERCISE


 


To:AMYRIS,
INC.


 


(1)  
The undersigned hereby elects to purchase ________ Warrant Shares of the Company pursuant to the terms of the attached Warrant
(only if exercised in full), and tenders herewith payment of the exercise price in full, together with all applicable transfer
taxes, if any.


 


(2)  
Exercise Price: $


 


(3)  
Payment shall take the form of (check applicable box):


 


[ ] in lawful money of the United
States; or


 


[ ] [the cancellation of such
number of Warrant Shares as is necessary, in accordance with the formula set forth in subsection 2(c), to exercise this Warrant
with respect to the maximum number of Warrant Shares purchasable pursuant to the cashless exercise procedure set forth in subsection
2(c).


 


(4)  
Please issue said Warrant Shares in the name of the undersigned or in such other name as is specified below:


 


_______________________________


 


 


The Warrant Shares shall be delivered to
the following DWAC Account Number:


 


_______________________________


 


_______________________________


 


_______________________________


 


(4) Accredited Investor.
The undersigned is an “accredited investor” as defined in Regulation D promulgated under the Securities Act of 1933,
as amended.


 


[SIGNATURE OF HOLDER]


 

	Name of Investing Entity:	 	 






	Signature of Authorized Signatory of
Investing Entity:	 	 






	Name of Authorized Signatory:	 	 





    19


     

    

	Title of Authorized Signatory: 	 	 






	Date:	 	 


 


 


 


 


 





 






    20


     

    

ASSIGNMENT FORM


(To assign the foregoing Warrant, execute
this form and supply required information. Do not use this form to purchase shares.)


 


FOR VALUE RECEIVED, the foregoing Warrant
and all rights evidenced thereby are hereby assigned to


 


	Name:	
	 	(Please Print)
	 	 
	Address:	
	
         
	
        (Please Print)

	 	 
	Phone Number:	 
	 	 
	Email Address:	 
	 	 
	Dated: _______________ __, ______	 



 


	Holder’s Signature:	 	 	 
	Holder’s Address:	 	 	 


 

 

 


 


 


 






    21


     

    

Exhibit B


 


FORM OF DILUTION WARRANT


 


 


 


 


 






     

     

    

 





NEITHER THIS SECURITY NOR THE SECURITIES
FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION
OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES
ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES
ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES
ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS. THIS SECURITY AND THE SECURITIES ISSUABLE UPON EXERCISE OF THIS SECURITY
MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN SECURED BY SUCH SECURITIES


 


COMMON STOCK PURCHASE WARRANT


 


AMYRIS,
INC. 


 


Issue Date: August __, 2017


 


THIS COMMON STOCK PURCHASE
WARRANT (the “Warrant”) certifies that, for value received, [__________] or its assigns (the “Holder”)
is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on
or after the date that Stockholder Approval (as defined in the Purchase Agreement) is obtained and deemed effective (the “Initial
Exercise Date”) and on or prior to the close of business on the five (5) year anniversary of the Initial Exercise Date
(the “Termination Date”) but not thereafter, to subscribe for and purchase from Amyris, Inc., a Delaware corporation
(the “Company”), up to that number of shares of the Company’s Common Stock equal to the Warrant Share
Amount (as defined below) (as subject to adjustment hereunder, the “Warrant Shares”). The purchase price of
one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).


 


Section 1.Definitions.


 


a)                 
Capitalized terms used and not otherwise defined herein shall have the meanings set forth in that certain Securities Purchase
Agreement (the “Purchase Agreement”), dated August 2, 2017, between the Company, the Holder and the other investors
party thereto.


 


b)                 
“Dilutive Issuance” means, other than an Exempt Issuance, during the period ending three (3) years from
the Issue Date, and while this Warrant is outstanding, an issuance by the Company or any Subsidiary thereof whereby the Company
or any Subsidiary thereof, as applicable, shall sell or grant any option to purchase, or sell or grant any right to reprice, or
otherwise dispose of or issue (or announce any offer, sale, grant or any option to purchase or other disposition) any Common Stock
or Common Stock Equivalents, at an effective price per share less than the Effective Price then in effect (such lower price, the
“Base Share Price”) (it being understood and agreed that if the holder of the Common Stock or Common Stock Equivalents
so issued shall at any time, whether by operation of purchase price adjustments, reset provisions, floating conversion, exercise
or exchange prices or otherwise, or due to warrants, options or rights per share which are issued in connection with such issuance,
be entitled to receive shares of Common Stock at an effective price per share that is less than the Effective Price, such issuance
shall be deemed to have occurred for less than the Effective Price on such date of the Dilutive Issuance at such effective price).


 



    1


     

    




c)                 
“Effective Price” means $4.26 per share (as adjusted for any stock splits, stock dividends, recapitalizations
or the like).


 


d)                
“Exempt Issuance” means the issuance of (a) shares of Common Stock or options to employees, officers
or directors of the Company pursuant to any stock or option plan or employee stock purchase plan duly adopted for such purpose,
by a majority of the non-employee members of the Board of Directors or a majority of the members of a committee of non-employee
directors established for such purpose for services rendered to the Company, (b) securities upon the exercise or exchange of or
conversion of any Securities issued under the Purchase Agreement and/or other securities exercisable or exchangeable for or convertible
into shares of Common Stock issued and outstanding, or committed for issuance, or as to which a dilution adjustment may be triggered,
or the payment of interest or principal in shares of Common Stock on securities which so provide, outstanding or committed for
issuance on the date of the Purchase Agreement, provided that such securities have not been amended since the date of the Purchase
Agreement to increase the number of such securities or to decrease the exercise price, exchange price or conversion price of such
securities (other than in connection with stock splits or combinations or adjustments pursuant to anti-dilution provisions existing
on the date hereof) or to extend the term of such securities, (c) securities issued pursuant to acquisitions or strategic transactions
approved by a majority of the disinterested directors of the Company, provided that any such issuance shall only be to a Person
(or to the equityholders of a Person) which is, itself or through its subsidiaries, an operating company or an owner of an asset
in a business synergistic with the business of the Company as determined in good faith by the Board of Directors and shall provide
to the Company additional benefits in addition to the investment of funds, but shall not include a transaction in which the Company
is issuing securities primarily for the purpose of raising capital or to an entity whose primary business is investing in securities,
and (d) any securities issued to DSM International B.V. in connection with the DSM Financing (as defined in the Purchase Agreement).


 


e)                 
“Warrant Share Amount” means a number of shares of Common Stock determined subsequent to any Dilutive
Issuance equal to the difference between (i) the quotient obtained by dividing the applicable Holder’s portion of the Purchase
Price by the greater of (A) the Base Share Price in the lowest-priced such Dilutive Issuance, and (B) $0.10 per share (as adjusted
for any stock splits, stock dividends, recapitalizations or the like), rounded down to the nearest share, minus (ii) the quotient
obtained by dividing the applicable Holder’s portion of the Purchase Price by the Effective Price, rounded down to the nearest
whole share, minus (iii) the number of shares that have been issued upon exercise of this Warrant following any prior Dilutive
Issuance. For the avoidance of doubt, on the Issue Date of this Warrant, the Warrant Share Amount shall equal zero; and if one
Dilutive Issuance is followed by a subsequent Dilutive Issuance at higher Base Share Price than the prior Dilutive Issuance, the
lower Base Share Price shall apply. For the avoidance of doubt, Vivo Capital Fund VIII, L.P.’s applicable portion of the
Purchase Price is $21,966,667.21; and Vivo Surplus Funds VIII, L.P.’s applicable portion of the Purchase Price is $3,033,332.79.


 



    2


     

    




Section 2.Exercise.


 


a)                 
Exercise of Warrant. Exercise of the purchase rights represented by this Warrant may be made, in whole or in part,
at any time or times on or after the Initial Exercise Date and on or before the Termination Date by delivery to the Company of
a duly executed facsimile copy or PDF copy submitted by electronic (or e-mail attachment) of the Notice of Exercise in the form
annexed hereto (“Notice of Exercise”). Within the earlier of (i) three (3) Trading Days (as defined in Section
2(c) herein) and (ii) the number of Trading Days comprising the Standard Settlement Period (as defined in Section 2(d)(i) herein)
following the date of exercise as aforesaid, the Holder shall deliver the aggregate Exercise Price for the shares specified in
the applicable Notice of Exercise by wire transfer or cashier’s check drawn on a United States bank unless the cashless exercise
procedure specified in Section 2(c) below is specified in the applicable Notice of Exercise. No ink-original Notice of Exercise
shall be required, nor shall any medallion guarantee (or other type of guarantee or notarization) of any Notice of Exercise form
be required. Notwithstanding anything herein to the contrary, the Holder shall not be required to physically surrender this Warrant
to the Company until the Holder has purchased all of the Warrant Shares available hereunder and the Warrant has been exercised
in full, in which case, the Holder shall surrender this Warrant to the Company for cancellation within three (3) Trading Days of
the date the final Notice of Exercise is delivered to the Company. Partial exercises of this Warrant resulting in purchases of
a portion of the total number of Warrant Shares available hereunder shall have the effect of lowering the outstanding number of
Warrant Shares purchasable hereunder in an amount equal to the applicable number of Warrant Shares purchased. The Company shall
maintain records showing the number of Warrant Shares purchased and the date of such purchases. The Company shall deliver any objection
to any Notice of Exercise within one (1) Business Day of receipt of such notice. The Holder and any assignee, by acceptance
of this Warrant, acknowledge and agree that, by reason of the provisions of this paragraph, following the purchase of a portion
of the Warrant Shares hereunder, the number of Warrant Shares available for purchase hereunder at any given time may be less than
the amount stated on the face hereof.


 


b)                 
Exercise Price. The exercise price per share of the Common Stock under this Warrant shall be $0.0001 subject to adjustment
hereunder (the “Exercise Price”).


 



    3


     

    




c)                 
Cashless Exercise. This Warrant may be exercised, in whole or in part, at any time or times on or after the Initial
Exercise Date and on or before the Termination Date at the election of the Holder (in such Holder’s sole discretion) by means
of a “cashless exercise” in which the Holder shall be entitled to receive a number of Warrant Shares equal to the quotient
obtained by dividing ((A-B) * (X)) by (A), where:


 


(A) = as applicable:
(i) the VWAP on the Trading Day immediately preceding the date of the applicable Notice of Exercise if such Notice of Exercise
is (1) both executed and delivered pursuant to Section 2(a) hereof on a day that is not a Trading Day or (2) both executed and
delivered pursuant to Section 2(a) hereof on a Trading Day prior to the opening of “regular trading hours” (as defined
in Rule 600(b)(64) of Regulation NMS promulgated under the federal securities laws) on such Trading Day, (ii) at the option of
the Holder, either (y) the VWAP on the Trading Day immediately preceding the date of the applicable Notice of Exercise or (z) the
Bid Price of the Common Stock on the principal Trading Market as reported by Bloomberg L.P. as of the time of the Holder’s
execution of the applicable Notice of Exercise if such Notice of Exercise is executed during “regular trading hours”
on a Trading Day and is delivered within two (2) hours thereafter pursuant to Section 2(a) hereof or (iii) the VWAP on the date
of the applicable Notice of Exercise if the date of such Notice of Exercise is a Trading Day and such Notice of Exercise is both
executed and delivered pursuant to Section 1(a) hereof after the close of “regular trading hours” on such Trading Day;


 


(B) = the
Exercise Price of this Warrant, as adjusted hereunder; and


 


(X) =
the number of Warrant Shares that would be issuable upon exercise of this Warrant in accordance with the terms of this Warrant
if such exercise were by means of a cash exercise rather than a cashless exercise.


 


If Warrant
Shares are issued in such a cashless exercise, the parties acknowledge and agree that in accordance with Section 3(a)(9) of the
Securities Act, the Warrant Shares shall take on the characteristics of the Warrants being exercised, and the holding period of
the Warrant Shares being issued may be tacked on to the holding period of this Warrant.  The Company agrees not to take
any position contrary to this Section 2(c).


 


“Bid
Price” means, for any date, the price determined by the first of the following clauses that applies: (a) if the Common
Stock is then listed or quoted on a Trading Market, the bid price of the Common Stock for the time in question (or the nearest
preceding date) on the Trading Market on which the Common Stock is then listed or quoted as reported by Bloomberg L.P. (based on
a Trading Day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time)), (b)  if OTCQB or OTCQX is not a Trading
Market, the volume weighted average price of the Common Stock for such date (or the nearest preceding date) on OTCQB or OTCQX as
applicable, (c) if the Common Stock is not then listed or quoted for trading on OTCQB or OTCQX and if prices for the Common Stock
are then reported in the “Pink Sheets” published by OTC Markets Group, Inc. (or a similar organization or agency succeeding
to its functions of reporting prices), the most recent bid price per share of the Common Stock so reported, or (d) in all
other cases, the fair market value of a share of Common Stock as determined by an independent appraiser selected in good faith
by the Purchaser and reasonably acceptable to the Company, the fees and expenses of which shall be paid by the Company.


 



    4


     

    




“VWAP”
means, for any date, the price determined by the first of the following clauses that applies: (a) if the Common Stock is then listed
or quoted on a Trading Market, the daily volume weighted average price of the Common Stock for such date (or the nearest preceding
date) on the Trading Market on which the Common Stock is then listed or quoted as reported by Bloomberg L.P. (based on a Trading
Day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time)), (b)  if OTCQB or OTCQX is not a Trading Market,
the volume weighted average price of the Common Stock for such date (or the nearest preceding date) on OTCQB or OTCQX as applicable,
(c) if the Common Stock is not then listed or quoted for trading on OTCQB or OTCQX and if prices for the Common Stock are then
reported in the “Pink Sheets” published by OTC Markets Group, Inc. (or a similar organization or agency succeeding
to its functions of reporting prices), the most recent bid price per share of the Common Stock so reported, or (d) in all
other cases, the fair market value of a share of Common Stock as determined by an independent appraiser selected in good faith
by the Purchaser and reasonably acceptable to the Company, the fees and expenses of which shall be paid by the Company.


 


“Trading
Day” means a day on which the principal Trading Market is open for trading.


 


“Trading
Market” means any of the following markets or exchanges on which the Common Stock is listed or quoted for trading on
the date in question: the NYSE MKT, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New
York Stock Exchange, OTCQB or OTCQX (or any successors to any of the foregoing).


 


 


Notwithstanding
anything herein to the contrary, on the Termination Date, this Warrant shall be automatically exercised via cashless exercise pursuant
to this Section 2(c).


 


d)                
Mechanics of Exercise.


 



    5


     

    




i.           
Delivery of Warrant Shares Upon Exercise. Warrant Shares purchased hereunder shall be transmitted by the Transfer
Agent to the Holder by crediting the account of the Holder’s or its designee’s balance account with The Depository
Trust Company through its Deposit or Withdrawal at Custodian system (“DWAC”) if the Company is then a participant
in such system and either (A) there is an effective registration statement permitting the issuance of the Warrant Shares to or
resale of the Warrant Shares by the Holder or (B) the Warrant Shares are eligible for resale by the Holder without volume or manner-of-sale
limitations pursuant to Rule 144, and otherwise by physical delivery of a certificate, registered in the Company’s share
register in the name of the Holder or its designee, for the number of Warrant Shares to which the Holder is entitled pursuant to
such exercise to the address specified by the Holder in the Notice of Exercise by the date that is the earlier of (i) the earlier
of (A) three (3) Trading Days after the delivery to the Company of the Notice of Exercise and (B) one (1) Trading Day after delivery
of the aggregate Exercise Price to the Company and (ii) the number of Trading Days comprising the Standard Settlement Period after
the delivery to the Company of the Notice of Exercise (such date, the “Warrant Share Delivery Date”). Upon delivery
of the Notice of Exercise, the Holder shall be deemed for all corporate purposes to have become the holder of record of the Warrant
Shares with respect to which this Warrant has been exercised, irrespective of the date of delivery of the Warrant Shares, provided
that payment of the aggregate Exercise Price (other than in the case of a cashless exercise) is received within the earlier of
(i) three Trading Days and (ii) the number of Trading Days comprising the Standard Settlement Period following delivery of the
Notice of Exercise. If the Company fails for any reason to deliver to the Holder the Warrant Shares subject to a Notice of Exercise
by the Warrant Share Delivery Date, the Company shall pay to the Holder, in cash, as liquidated damages and not as a penalty, for
each $1,000 of Warrant Shares subject to such exercise (based on the VWAP of the Common Stock on the date of the applicable Notice
of Exercise), $10 per Trading Day (increasing to $20 per Trading Day on the fifth Trading Day after such liquidated damages begin
to accrue) for each Trading Day commencing one Trading Day after such Warrant Share Delivery Date until such Warrant Shares are
delivered or Holder rescinds such exercise. The Company agrees to maintain a transfer agent that is a participant in the FAST program
so long as this Warrant remains outstanding and exercisable. As used herein, “Standard Settlement Period” means
the standard settlement period, expressed in a number of Trading Days, on the Company’s primary Trading Market with respect
to the Common Stock as in effect on the date of delivery of the Notice of Exercise.


 


ii.                    
Delivery of New Warrants Upon Exercise. If this Warrant shall have been exercised in part, the Company shall, at
the request of a Holder and upon surrender of this Warrant certificate, at the time of delivery of the Warrant Shares, deliver
to the Holder a new Warrant evidencing the rights of the Holder to purchase the unpurchased Warrant Shares called for by this Warrant,
which new Warrant shall in all other respects be identical with this Warrant.


 



    6


     

    




iii.                 
Rescission Rights. If the Company fails to cause the Transfer Agent to transmit to the Holder the Warrant Shares
pursuant to Section 2(d)(i) by the Warrant Share Delivery Date, then the Holder will have the right to rescind such exercise.


 


iv.                 
Compensation for Buy-In on Failure to Timely Deliver Warrant Shares. In addition to any other rights available to
the Holder, if the Company fails to cause the Transfer Agent to transmit to the Holder the Warrant Shares in accordance with the
provisions of Section 2(d)(i) above pursuant to an exercise on or before the Warrant Share Delivery Date, and if after such date
the Holder is required by its broker to purchase (in an open market transaction or otherwise) or the Holder’s brokerage firm
otherwise purchases, shares of Common Stock to deliver in satisfaction of a sale by the Holder of the Warrant Shares which the
Holder anticipated receiving upon such exercise (a “Buy-In”), then the Company shall (A) pay in cash to the
Holder the amount, if any, by which (x) the Holder’s total purchase price (including brokerage commissions, if any) for the
shares of Common Stock so purchased exceeds (y) the amount obtained by multiplying (1) the number of Warrant Shares that the Company
was required to deliver to the Holder in connection with the exercise at issue times (2) the price at which the sell order giving
rise to such purchase obligation was executed, and (B) at the option of the Holder, either reinstate the portion of the Warrant
and equivalent number of Warrant Shares for which such exercise was not honored (in which case such exercise shall be deemed rescinded)
or deliver to the Holder the number of shares of Common Stock that would have been issued had the Company timely complied with
its exercise and delivery obligations hereunder. For example, if the Holder purchases Common Stock having a total purchase price
of $11,000 to cover a Buy-In with respect to an attempted exercise of shares of Common Stock with an aggregate sale price giving
rise to such purchase obligation of $10,000, under clause (A) of the immediately preceding sentence the Company shall be required
to pay the Holder $1,000. The Holder shall provide the Company written notice indicating the amounts payable to the Holder in respect
of the Buy-In and, upon request of the Company, evidence of the amount of such loss. Nothing herein shall limit a Holder’s
right to pursue any other remedies available to it hereunder, at law or in equity including, without limitation, a decree of specific
performance and/or injunctive relief with respect to the Company’s failure to timely deliver shares of Common Stock upon
exercise of the Warrant as required pursuant to the terms hereof.


 


v.                 
No Fractional Shares or Scrip. No fractional shares or scrip representing fractional shares shall be issued upon
the exercise of this Warrant. As to any fraction of a share which the Holder would otherwise be entitled to purchase upon such
exercise, the Company shall, at its election, either pay a cash adjustment in respect of such final fraction in an amount equal
to such fraction multiplied by the Exercise Price or round up to the next whole share.


 



    7


     

    




vi.                 
Charges, Taxes and Expenses. Issuance of Warrant Shares shall be made without charge to the Holder for any issue
or transfer tax or other incidental expense in respect of the issuance of such Warrant Shares, all of which taxes and expenses
shall be paid by the Company, and such Warrant Shares shall be issued in the name of the Holder or in such name or names as may
be directed by the Holder; provided, however, that in the event that Warrant Shares are to be issued in a name other
than the name of the Holder, this Warrant when surrendered for exercise shall be accompanied by the Assignment Form attached hereto
duly executed by the Holder and the Company may require, as a condition thereto, the payment of a sum sufficient to reimburse it
for any transfer tax incidental thereto. The Company shall pay all Transfer Agent fees required for same-day processing of any
Notice of Exercise and all fees to the Depository Trust Company (or another established clearing corporation performing similar
functions) required for same-day electronic delivery of the Warrant Shares.


 


vii.                 
Closing of Books. The Company will not close its stockholder books or records in any manner which prevents the timely
exercise of this Warrant, pursuant to the terms hereof.


 



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e)       Holder’s
Exercise Limitations. Notwithstanding anything to the contrary contained herein, the Company shall not effect any exercise
of this Warrant, and a Holder shall not have the right to exercise any portion of this Warrant, pursuant to Section 2 or otherwise,
to the extent that after giving effect to such issuance after exercise as set forth on the applicable Notice of Exercise, the Holder
(together with the Holder’s Affiliates, and any other Persons acting as a group together with the Holder or any of the Holder’s
Affiliates (such Persons, “Attribution Parties”)), would beneficially own in excess of the Beneficial Ownership
Limitation (as defined below).  For purposes of the foregoing sentence, the number of shares of Common Stock beneficially
owned by the Holder and its Affiliates and Attribution Parties shall include the number of shares of Common Stock issuable upon
exercise of this Warrant with respect to which such determination is being made, but shall exclude the number of shares of Common
Stock which would be issuable upon (i) exercise of the remaining, nonexercised portion of this Warrant beneficially owned by the
Holder or any of its Affiliates or Attribution Parties and (ii) exercise or conversion of the unexercised or nonconverted portion
of any other securities of the Company (including, without limitation, any other Common Stock Equivalents (as defined below)) subject
to a limitation on conversion or exercise analogous to the limitation contained herein beneficially owned by the Holder or any
of its Affiliates or Attribution Parties.  Except as set forth in the preceding sentence, for purposes of this Section 2(e),
beneficial ownership shall be calculated in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated
thereunder, it being acknowledged by the Holder that the Company is not representing to the Holder that such calculation is in
compliance with Section 13(d) of the Exchange Act and the Holder is solely responsible for any schedules required to be filed in
accordance therewith. To the extent that the limitation contained in this Section 2(e) applies, the determination of whether this
Warrant is exercisable (in relation to other securities owned by the Holder together with any Affiliates and Attribution Parties)
and of which portion of this Warrant is exercisable shall be in the sole discretion of the Holder, and the submission of a Notice
of Exercise shall be deemed to be the Holder’s determination of whether this Warrant is exercisable (in relation to other
securities owned by the Holder together with any Affiliates and Attribution Parties) and of which portion of this Warrant is exercisable,
in each case subject to the Beneficial Ownership Limitation, and the Company shall have no obligation to verify or confirm the
accuracy of such determination. In addition, a determination as to any group status as contemplated above shall be determined in
accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder. For purposes of this Section
2(e), in determining the number of outstanding shares of Common Stock, a Holder may rely on the number of outstanding shares of
Common Stock as reflected in (A) the Company’s most recent periodic or annual report filed with the Commission, as the case
may be, (B) a more recent public announcement by the Company or (C) a more recent written notice by the Company or the Transfer
Agent setting forth the number of shares of Common Stock outstanding.  Upon the written or oral request of a Holder, the Company
shall within two Trading Days confirm orally and in writing to the Holder the number of shares of Common Stock then outstanding. 
In any case, the number of outstanding shares of Common Stock shall be determined after giving effect to the conversion or exercise
of securities of the Company, including this Warrant, by the Holder or its Affiliates or Attribution Parties since the date as
of which such number of outstanding shares of Common Stock was reported. The “Beneficial Ownership Limitation”
shall be 9.99% of the number of shares of the Common Stock outstanding immediately after giving effect to the issuance of shares
of Common Stock issuable upon exercise of this Warrant. The Holder, upon notice to the Company, may waive the Beneficial Ownership
Limitation provisions of this Section 2(e), provided that such waiver (i) will not be effective until the 61st day after
such notice is delivered to the Company, and (ii) will not be effective to the extent such waiver would require the prior approval
of the Company’s stockholders, unless such approval has been obtained. If such stockholder approval is required and has not
been obtained, the Corporation shall use its commercially reasonable efforts to timely obtain such stockholder approval. The provisions
of this paragraph shall be construed and implemented in a manner otherwise than in strict conformity with the terms of this Section
2(e) to correct this paragraph (or any portion hereof) which may be defective or inconsistent with the intended Beneficial Ownership
Limitation herein contained or to make changes or supplements necessary or desirable to properly give effect to such limitation.
The limitations contained in this paragraph shall apply to a successor holder of this Warrant. “Common Stock Equivalents”
means any securities of the Company or its subsidiaries which would entitle the holder thereof to acquire at any time Common Stock,
including, without limitation, any debt, preferred stock, right, option, warrant or other instrument that is at any time convertible
into, or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Common Stock.


 



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Section 3.Certain
Adjustments.


 


a)  
Stock Dividends and Splits. If the Company, at any time while this Warrant is outstanding: (i) pays a stock dividend
or otherwise makes a distribution or distributions on shares of its Common Stock or any other equity or equity equivalent securities
payable in shares of Common Stock (which, for avoidance of doubt, shall not include any shares of Common Stock issued by the Company
upon exercise of this Warrant), (ii) subdivides outstanding shares of Common Stock into a larger number of shares, (iii) combines
(including by way of reverse stock split) outstanding shares of Common Stock into a smaller number of shares or (iv) issues by
reclassification of shares of the Common Stock any shares of capital stock of the Company, then in each case the Exercise Price
shall be multiplied by a fraction of which the numerator shall be the number of shares of Common Stock (excluding treasury shares,
if any) outstanding immediately before such event and of which the denominator shall be the number of shares of Common Stock outstanding
immediately after such event, and the number of shares issuable upon exercise of this Warrant shall be proportionately adjusted
such that the aggregate Exercise Price of this Warrant shall remain unchanged. Any adjustment made pursuant to this Section 3(a)
shall become effective immediately after the record date for the determination of stockholders entitled to receive such dividend
or distribution and shall become effective immediately after the effective date in the case of a subdivision, combination or re-classification.


 


b)  
Subsequent Rights Offerings. In addition to any adjustments pursuant to Section 3(a) above, if at any time subsequent
to the Issue Date of this Warrant but prior to the date the Company obtains the Stockholder Approval the Company grants, issues
or sells any Common Stock Equivalents or rights to purchase stock, warrants, securities or other property pro rata to the record
holders of any class of shares of Common Stock (the “Purchase Rights”), then the Holder will be entitled to
acquire, upon the terms applicable to such Purchase Rights, the aggregate Purchase Rights which the Holder could have acquired
if the Holder had held the number of shares of Common Stock acquirable upon complete exercise of this Warrant (without regard to
any limitations on exercise hereof, including without limitation, the Beneficial Ownership Limitation) immediately before the date
on which a record is taken for the grant, issuance or sale of such Purchase Rights, or, if no such record is taken, the date as
of which the record holders of shares of Common Stock are to be determined for the grant, issue or sale of such Purchase Rights
(provided, however, to the extent that the Holder’s right to participate in any such Purchase Right would result in the Holder
exceeding the Beneficial Ownership Limitation and the Beneficial Ownership Limitation is not waived by the Holder, then the Holder
shall not be entitled to participate in such Purchase Right to such extent (or beneficial ownership of such shares of Common Stock
as a result of such Purchase Right to such extent) and such Purchase Right to such extent shall be held in abeyance for the Holder
until such time, if ever, as its right thereto would not result in the Holder exceeding the Beneficial Ownership Limitation).


 



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c)  
Pro Rata Distributions. During such time as this Warrant is outstanding, if the Company shall declare or make any
dividend or other distribution of its assets (or rights to acquire its assets) to holders of shares of Common Stock, by way of
return of capital or otherwise (including, without limitation, any distribution of cash, stock or other securities, property or
options by way of a dividend, spin off, reclassification, corporate rearrangement, scheme of arrangement or other similar transaction,
but excluding any dividend that results in adjustment to the Conversion Price pursuant to Section 3(a) above) (a “Distribution”),
at any time after the issuance of this Warrant, then, in each such case, the Holder shall be entitled to participate in such Distribution
to the same extent that the Holder would have participated therein if the Holder had held the number of shares of Common Stock
acquirable upon complete exercise of this Warrant (without regard to any limitations on exercise hereof, including without limitation,
the Beneficial Ownership Limitation) immediately before the date of which a record is taken for such Distribution, or, if no such
record is taken, the date as of which the record holders of shares of Common Stock are to be determined for the participation in
such Distribution (provided, however, to the extent that the Holder's right to participate in any such Distribution
would result in the Holder exceeding the Beneficial Ownership Limitation and the Beneficial Ownership Limitation is not waived
by the Holder, then the Holder shall not be entitled to participate in such Distribution to such extent (or in the beneficial ownership
of any shares of Common Stock as a result of such Distribution to such extent) and the portion of such Distribution shall be held
in abeyance for the benefit of the Holder until such time, if ever, as its right thereto would not result in the Holder exceeding
the Beneficial Ownership Limitation).


 


d) 
Fundamental Transaction. If, at any time while this Warrant is outstanding, (i) the Company, directly or indirectly,
in one or more related transactions effects any merger or consolidation of the Company with or into another Person, (ii) the Company,
directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other disposition of all or substantially
all of its assets in one or a series of related transactions, (iii) any, direct or indirect, purchase offer, tender offer or exchange
offer (whether by the Company or another Person) is completed pursuant to which holders of Common Stock are permitted to sell,
tender or exchange their shares for other securities, cash or property and has been accepted by the holders of 50% or more of the
outstanding Common Stock, (iv) the Company, directly or indirectly, in one or more related transactions effects any reclassification,
reorganization or recapitalization of the Common Stock or any compulsory share exchange pursuant to which the Common Stock is effectively
converted into or exchanged for other securities, cash or property, or (v) the Company, directly or indirectly, in one or more
related transactions consummates a stock or share purchase agreement or other business combination (including, without limitation,
a reorganization, recapitalization, spin-off or scheme of arrangement) with another Person or group of Persons whereby such other
Person or group acquires more than 50% of the outstanding shares of Common Stock (not including any shares of Common Stock held
by the other Person or other Persons making or party to, or associated or affiliated with the other Persons making or party to,
such stock or share purchase agreement or other business combination) (each a “Fundamental Transaction”), then,
the Holder shall have the right to receive, for each Warrant Share that would have been issuable upon such exercise immediately
prior to the occurrence of such Fundamental Transaction (as if the exercise of the Warrant occurred immediately prior to the occurrence
of such Fundamental Transaction), at the option of the Holder (without regard to any limitation in Section 2(e) on the exercise
of this Warrant), the number of shares of common stock of the successor or acquiring corporation or shares of Common Stock of the
Company, if it is the surviving corporation, and any additional consideration (the “Alternate Consideration”)
receivable as a result of such Fundamental Transaction by a holder of the number of shares of Common Stock for which this Warrant
is exercisable immediately prior to such Fundamental Transaction (without regard to any limitation in Section 2(e) on the exercise
of this Warrant). For purposes of any such exercise, the determination of the Exercise Price shall be appropriately adjusted to
apply to such Alternate Consideration based on the amount of Alternate Consideration issuable in respect of one share of Common
Stock in such Fundamental Transaction, and the Company shall apportion the Exercise Price among the Alternate Consideration in
a reasonable manner reflecting the relative value of any different components of the Alternate Consideration. If holders of Common
Stock are given any choice as to the securities, cash or property to be received in a Fundamental Transaction, then the Holder
shall be given the same choice as to the Alternate Consideration it receives upon any exercise of this Warrant following such Fundamental
Transaction.


 



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e)  
Calculations. All calculations under this Section 3 shall be made to the nearest cent or the nearest 1/100th of a
share, as the case may be. For purposes of this Section 3, the number of shares of Common Stock deemed to be issued and outstanding
as of a given date shall be the sum of the number of shares of Common Stock (excluding treasury shares, if any) issued and outstanding.


 


f)   
Notice to Holder.


 


i.     
Notice of Dilutive Issuance. The Company shall notify the Holder, in writing, no later than the Trading Day following
the issuance or deemed issuance of any Common Stock or Common Stock Equivalents pursuant to a Dilutive Issuance, indicating therein
the applicable Base Share Price and the resulting Warrant Share Amount.


 


ii.     
Adjustment to Exercise Price. Whenever the Exercise Price is adjusted pursuant to any provision of this Section 3,
the Company shall within two (2) Trading Days deliver to the Holder by facsimile or email a notice setting forth the Exercise Price
after such adjustment and any resulting adjustment to the number of Warrant Shares and setting forth a brief statement of the facts
requiring such adjustment.


 



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iii.     
Notice to Allow Exercise by Holder. If (A) the Company shall declare a dividend (or any other distribution in whatever
form) on the Common Stock, (B) the Company shall declare a special nonrecurring cash dividend on or a redemption of the Common
Stock, (C) the Company shall authorize the granting to all holders of the Common Stock rights or warrants to subscribe for or purchase
any shares of capital stock of any class or of any rights, (D) the approval of any stockholders of the Company shall be required
in connection with any reclassification of the Common Stock, any consolidation or merger to which the Company is a party, any sale
or transfer of all or substantially all of the assets of the Company, or any compulsory share exchange whereby the Common Stock
is converted into other securities, cash or property, or (E) the Company shall authorize the voluntary or involuntary dissolution,
liquidation or winding up of the affairs of the Company, then, in each case, the Company shall cause to be delivered by facsimile
or email to the Holder at its last facsimile number or email address as it shall appear upon the Warrant Register of the Company,
at least 20 calendar days prior to the applicable record or effective date hereinafter specified, a notice stating (x) the date
on which a record is to be taken for the purpose of such dividend, distribution, redemption, rights or warrants, or if a record
is not to be taken, the date as of which the holders of the Common Stock of record to be entitled to such dividend, distributions,
redemption, rights or warrants are to be determined or (y) the date on which such reclassification, consolidation, merger, sale,
transfer or share exchange is expected to become effective or close, and the date as of which it is expected that holders of the
Common Stock of record shall be entitled to exchange their shares of the Common Stock for securities, cash or other property deliverable
upon such reclassification, consolidation, merger, sale, transfer or share exchange; provided that the failure to deliver such
notice or any defect therein or in the delivery thereof shall not affect the validity of the corporate action required to be specified
in such notice. To the extent that any notice provided in this Warrant constitutes, or contains, material, non-public information
regarding the Company or any of the Subsidiaries, the Company shall simultaneously file such notice with the Commission pursuant
to a Current Report on Form 8-K. The Holder shall remain entitled to exercise this Warrant during the period commencing on the
date of such notice to the effective date of the event triggering such notice except as may otherwise be expressly set forth herein.


 


Section 4.Transfer
of Warrant.


 


a)                 
Transferability. Subject to compliance with any applicable securities laws and the conditions set forth in Section
4(d) hereof and to the provisions of Section 4 and 7.3 of the Purchase Agreement, this Warrant and all rights hereunder (including,
without limitation, any registration rights) are transferable, in whole or in part, upon surrender of this Warrant at the principal
office of the Company or its designated agent, together with a written assignment of this Warrant substantially in the form attached
hereto duly executed by the Holder or its agent or attorney and funds sufficient to pay any transfer taxes payable upon the making
of such transfer. Upon such surrender and, if required, such payment, the Company shall execute and deliver a new Warrant or Warrants
in the name of the assignee or assignees, as applicable, and in the denomination or denominations specified in such instrument
of assignment, and shall issue to the assignor a new Warrant evidencing the portion of this Warrant not so assigned, and this Warrant
shall promptly be cancelled. Notwithstanding anything herein to the contrary, the Holder shall not be required to physically surrender
this Warrant to the Company unless the Holder has assigned this Warrant in full, in which case, the Holder shall surrender this
Warrant to the Company within three (3) Trading Days of the date the Holder delivers an assignment form to the Company assigning
this Warrant full. The Warrant, if properly assigned in accordance herewith, may be exercised by a new holder for the purchase
of Warrant Shares without having a new Warrant issued.


 



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b)                 
New Warrants. This Warrant may be divided or combined with other Warrants upon presentation hereof at the aforesaid
office of the Company, together with a written notice specifying the names and denominations in which new Warrants are to be issued,
signed by the Holder or its agent or attorney. Subject to compliance with Section 4(a), as to any transfer which may be involved
in such division or combination, the Company shall execute and deliver a new Warrant or Warrants in exchange for the Warrant or
Warrants to be divided or combined in accordance with such notice. All Warrants issued on transfers or exchanges shall be dated
the original issue date and shall be identical with this Warrant except as to the number of Warrant Shares issuable pursuant thereto.


 


c)                 
Warrant Register. The Company shall register this Warrant, upon records to be maintained by the Company for that
purpose (the “Warrant Register”), in the name of the record Holder hereof from time to time. The Company may
deem and treat the registered Holder of this Warrant as the absolute owner hereof for the purpose of any exercise hereof or any
distribution to the Holder, and for all other purposes, absent actual notice to the contrary.


 


d)                
Transfer Restrictions. If, at the time of the surrender of this Warrant in connection with any transfer of this Warrant,
the transfer of this Warrant shall not be either (i) registered pursuant to an effective registration statement under the Securities
Act and under applicable state securities or blue sky laws or (ii) eligible for resale without volume or manner-of-sale restrictions
or current public information requirements pursuant to Rule 144, the Company may require, as a condition of allowing such transfer,
that the Holder or transferee of this Warrant, as the case may be, comply with the provisions of Section 8.3 of the Purchase Agreement.


 


e)                 
Representation by the Holder. The Holder, by the acceptance hereof, represents and warrants that it is acquiring
this Warrant and, upon any exercise hereof, will acquire the Warrant Shares issuable upon such exercise, for its own account and
not with a view to or for distributing or reselling such Warrant Shares or any part thereof in violation of the Securities Act
or any applicable state securities law, except pursuant to sales registered or exempted under the Securities Act.


 



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Section 5.Miscellaneous.


 


a)                 
No Rights as Stockholder Until Exercise. This Warrant does not entitle the Holder to any voting rights, dividends
or other rights as a stockholder of the Company prior to the exercise hereof as set forth in Section 2(d)(i), except as expressly
set forth in Section 3.


 


b)     
Loss, Theft, Destruction or Mutilation of Warrant. The Company covenants that upon receipt by the Company of evidence
reasonably satisfactory to it of the loss, theft, destruction or mutilation of this Warrant or any stock certificate relating to
the Warrant Shares, and in case of loss, theft or destruction, of indemnity or security reasonably satisfactory to it (which, in
the case of the Warrant, shall not include the posting of any bond), and upon surrender and cancellation of such Warrant or stock
certificate, if mutilated, the Company will make and deliver a new Warrant or stock certificate of like tenor and dated as of such
cancellation, in lieu of such Warrant or stock certificate.


 


c)     
Saturdays, Sundays, Holidays, etc. If the last or appointed day for the taking of any action or the expiration of
any right required or granted herein shall not be a Business Day, then, such action may be taken or such right may be exercised
on the next succeeding Business Day.


 


d)    
Authorized Shares.


 


During the period
the Warrant is outstanding from and after the Initial Exercise Date, the Company covenants that it will reserve from its authorized
and unissued Common Stock a sufficient number of shares to provide for the issuance of the Warrant Shares upon the exercise of
any purchase rights under this Warrant. The Company further covenants that its issuance of this Warrant shall constitute full authority
to its officers who are charged with the duty of issuing the necessary Warrant Shares upon the exercise of the purchase rights
under this Warrant. The Company will take all such reasonable action as may be necessary to assure that such Warrant Shares may
be issued as provided herein without violation of any applicable law or regulation, or of any requirements of the Trading Market
upon which the Common Stock may be listed. The Company covenants that all Warrant Shares which may be issued upon the exercise
of the purchase rights represented by this Warrant will, upon exercise of the purchase rights represented by this Warrant and payment
for such Warrant Shares in accordance herewith, be duly authorized, validly issued, fully paid and nonassessable and free from
all taxes, liens and charges created by the Company in respect of the issue thereof (other than taxes in respect of any transfer
occurring contemporaneously with such issue).


 



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Except and
to the extent as waived or consented to by the Holder, the Company shall not by any action, including, without limitation, amending
its certificate of incorporation or through any reorganization, transfer of assets, consolidation, merger, dissolution, issue or
sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms of this
Warrant, but will at all times in good faith assist in the carrying out of all such terms and in the taking of all such actions
as may be necessary or appropriate to protect the rights of Holder as set forth in this Warrant against impairment. Without limiting
the generality of the foregoing, the Company will (i) not increase the par value of any Warrant Shares above the amount payable
therefor upon such exercise immediately prior to such increase in par value, (ii) take all such action as may be necessary or appropriate
in order that the Company may validly and legally issue fully paid and nonassessable Warrant Shares upon the exercise of this Warrant
and (iii) use commercially reasonable efforts to obtain all such authorizations, exemptions or consents from any public regulatory
body having jurisdiction thereof, as may be, necessary to enable the Company to perform its obligations under this Warrant.


 


Before taking
any action which would result in an adjustment in the number of Warrant Shares for which this Warrant is exercisable or in the
Exercise Price, the Company shall obtain all such authorizations or exemptions thereof, or consents thereto, as may be necessary
from any public regulatory body or bodies having jurisdiction thereof.


 


e)     
Jurisdiction. All questions concerning the construction, validity, enforcement and interpretation of this Warrant
shall be determined in accordance with the provisions of the Purchase Agreement.


 


f)      
Restrictions. The Holder acknowledges that the Warrant Shares acquired upon the exercise of this Warrant, if not
registered and the Holder does not utilize cashless exercise, will have restrictions upon resale imposed by state and federal securities
laws.


 


g)     
Nonwaiver and Expenses. No course of dealing or any delay or failure to exercise any right hereunder on the part
of Holder shall operate as a waiver of such right or otherwise prejudice the Holder’s rights, powers or remedies, notwithstanding
the fact that all rights hereunder terminate on the Termination Date. If the Company willfully and knowingly fails to comply with
any provision of this Warrant, which results in any material damages to the Holder, the Company shall pay to the Holder such amounts
as shall be sufficient to cover any costs and expenses including, but not limited to, reasonable attorneys’ fees, including
those of appellate proceedings, incurred by the Holder in collecting any amounts due pursuant hereto or in otherwise enforcing
any of its rights, powers or remedies hereunder.


 



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h)     
Notices. Any notice, request or other document required or permitted to be given or delivered to the Holder by the
Company shall be delivered in accordance with the notice provisions of the Purchase Agreement.


 


i)       
Limitation of Liability. No provision hereof, in the absence of any affirmative action by the Holder to exercise
this Warrant to purchase Warrant Shares, and no enumeration herein of the rights or privileges of the Holder, shall give rise to
any liability of the Holder for the purchase price of any Common Stock or as a stockholder of the Company, whether such liability
is asserted by the Company or by creditors of the Company.


 


j)       
Remedies. The Holder, in addition to being entitled to exercise all rights granted by law, including recovery of
damages, will be entitled to specific performance of its rights under this Warrant. The Company agrees that monetary damages would
not be adequate compensation for any loss incurred by reason of a breach by it of the provisions of this Warrant and hereby agrees
to waive and not to assert the defense in any action for specific performance that a remedy at law would be adequate.


 


k)     
Successors and Assigns. Subject to applicable securities laws, this Warrant and the rights and obligations evidenced
hereby shall inure to the benefit of and be binding upon the successors and permitted assigns of the Company and the successors
and permitted assigns of Holder. The provisions of this Warrant are intended to be for the benefit of any Holder from time to time
of this Warrant and shall be enforceable by the Holder or holder of Warrant Shares.


 


l)       
Amendment. This Warrant may be modified or amended or the provisions hereof waived with the written consent of the
Company and the Holder.


 


m)   
Severability. Wherever possible, each provision of this Warrant shall be interpreted in such manner as to be effective
and valid under applicable law, but if any provision of this Warrant shall be prohibited by or invalid under applicable law, such
provision shall be ineffective to the extent of such prohibition or invalidity, without invalidating the remainder of such provisions
or the remaining provisions of this Warrant.


 


n)     
Headings. The headings used in this Warrant are for the convenience of reference only and shall not, for any purpose,
be deemed a part of this Warrant.


 


 


********************


 


 


(Signature Page Follows)


 


 



    17


     

    




IN WITNESS WHEREOF, the
Company has caused this Warrant to be executed by its officer thereunto duly authorized as of the date first above indicated.


 


 

	 	AMYRIS, INC.



	 	 
	 	 
	 	By:	
         

	 	 	Name:
	 	 	Title:


 


 


 


 






    18


     

    

NOTICE OF EXERCISE


 


To:AMYRIS,
INC.


 


(5)  
The undersigned hereby elects to purchase ________ Warrant Shares of the Company pursuant to the terms of the attached Warrant
(only if exercised in full), and tenders herewith payment of the exercise price in full, together with all applicable transfer
taxes, if any.


 


(6)  
Exercise Price: $


 


(7)  
Payment shall take the form of (check applicable box):


 


[ ] in lawful money of the United
States; or


 


[ ] [the cancellation of such
number of Warrant Shares as is necessary, in accordance with the formula set forth in subsection 2(c), to exercise this Warrant
with respect to the maximum number of Warrant Shares purchasable pursuant to the cashless exercise procedure set forth in subsection
2(c).


 


(8)  
Please issue said Warrant Shares in the name of the undersigned or in such other name as is specified below:


 


_______________________________


 


 


The Warrant Shares shall be delivered to
the following DWAC Account Number:


 


_______________________________


 


_______________________________


 


_______________________________


 


(4) Accredited Investor.
The undersigned is an “accredited investor” as defined in Regulation D promulgated under the Securities Act of 1933,
as amended.


 


[SIGNATURE OF HOLDER]


 


	Name of Investing Entity: 	 	 






	Signature of Authorized Signatory of Investing Entity:
	 	 






	Name of Authorized Signatory:	 	 



 



    19


     

    











	Title of Authorized Signatory: 	 	 






	Date:	 	 



 


 


 


 


 





 






    20


     

    

ASSIGNMENT FORM


(To assign the foregoing Warrant, execute
this form and supply required information. Do not use this form to purchase shares.)


 


FOR VALUE RECEIVED, the foregoing Warrant
and all rights evidenced thereby are hereby assigned to


 


 


	Name:	
	 	(Please Print)
	 	 
	Address:	
	
         
	
        (Please Print)

	 	 
	Phone Number:	 
	 	 
	Email Address:	 
	 	 
	Dated: _______________ __, ______	 



 


	Holder’s Signature:	 	 	 
	Holder’s Address:	 	 	 


 


 


 






    21


     

    

Exhibit C


 


FORM OF STOCKHOLDER AGREEMENT


 


 


 


 


 


 





 


 


 


 






     

     

    

 


 


 


 


 


 


 


 


 



STOCKHOLDER AGREEMENT


 


Dated as of August [●], 2017


 


 



 


 


 


 


 


 


 






     


     

    

TABLE OF CONTENTS


 


Page




	ARTICLE I DEFINITIONS	 
	Section 1.1.   Definitions	1
	Section 1.2.   General Interpretive Principles	4
	ARTICLE II GOVERNANCE	 
	Section 2.1.   Board of Directors	5
	ARTICLE III TRANSFER RESTRICTIONS	 
	Section 3.1.   General Transfer Restrictions	8
	Section 3.2.   Specific Transfer Restrictions	8
	Section 3.3.   Permitted Transfers.	9
	ARTICLE IV	 
	SHARE OWNERSHIP	 
	Section 4.1.   Standstill	10
	Section 4.2.   Preemptive Rights	11
	ARTICLE V REGISTRATION RIGHTS	 
	Section 5.1.   Certain Definitions	13
	Section 5.2.   Registration	14
	Section 5.3.   Piggyback Registration.	19
	Section 5.4.   Expenses of Registration	20
	Section 5.5.   Obligations of the Company	20
	Section 5.6.   Indemnification.	22



 



     


     

    




	Section 5.7.   Information by Holder	25
	Section 5.8.   Transfer of Registration Rights	25
	Section 5.9.   Delay of Registration	25
	Section 5.10.   Termination of Registration Rights	25
	ARTICLE VI	 
	TERMINATION	 
	Section 6.1.   Termination	25
	ARTICLE VII MISCELLANEOUS	 
	Section 7.1.   Entire Agreement	25
	Section 7.2.   Specific Performance	25
	Section 7.3.   Governing Law	26
	Section 7.4.   Amendment and Waiver	26
	Section 7.5.   Binding Effect	26
	Section 7.6.   Notices	26
	Section 7.7.   Severability	26
	Section 7.8.   Counterparts	26


 






    ii


     

    

STOCKHOLDER AGREEMENT


 


This STOCKHOLDER AGREEMENT is made as of August
[●], 2017, by and among Amyris, Inc., a Delaware corporation (“Amyris” or the “Company”),
and each of Vivo Capital Fund VIII, L.P., a Delaware limited partnership, and Vivo Surplus Funds VIII, L.P., a Delaware limited
partnership (hereinafter collectively referred to as “Vivo”).


 


WHEREAS, Vivo and Company have entered into
the Securities Purchase Agreement, dated as of August 2, 2017 (as may be amended from time to time, the “Securities Purchase
Agreement”), pursuant to which, upon the terms and subject to the conditions set forth therein, Vivo agreed to purchase
an aggregate of (i) 2,826,711 shares (the “Common Shares”) of the Company’s common stock, $0.0001 par
value per share (the “Common Stock”), (ii) 12,958.21196 shares (the “Preferred Shares” and
together with the Common Shares, the “Shares”) of the Company’s Series
D Convertible Preferred Stock, $0.0001 par value per share (the “Preferred Stock”), (iii) a warrant to
acquire up to 5,575,118 shares of Common Stock (the “Cash Warrant” and the shares of Common Stock issuable upon
exercise of the Cash Warrant, the “Cash Warrant Shares”), and (iv) a warrant to purchase shares of Common Stock
as a result of certain dilutive issuances of equity by the Company (the “Anti-Dilution Warrant” and, together
with the Cash Warrant, the “Warrants,” and the shares of Common Stock issuable upon exercise of the Anti-Dilution
Warrant, the “Anti-Dilution Warrant Shares” and, together with the Cash Warrant Shares, the “Warrant
Shares”); and


 


WHEREAS, Vivo and the Company desire to set
forth certain rights and obligations of Vivo and the Company with respect to Vivo’s investment in the Company.


 


NOW, THEREFORE, in consideration of the mutual
covenants and agreements contained herein, the parties mutually agree as follows:


 


ARTICLE
I



DEFINITIONS


 


Section 1.1.                     
Definitions. As used in this Agreement, the following terms shall have the meanings set forth below:


 


“Affiliate” means, with
respect to any Person, any other Person that controls, is controlled by, or is under common control with such Person. The term
“control”, as used with respect to any Person, means the power to direct or cause the direction of the management
and policies of such Person, directly or indirectly, whether through the ownership of voting securities, by contract or otherwise.
“Controlled” and “controlling” have meanings correlative to the foregoing.


 


“Agreement” means this
Stockholder Agreement, as the same may be amended, supplemented, restated or modified.


 


“Beneficial Ownership”
and “Beneficially Own” and similar terms have the meaning set forth in Rule 13d-3 under the Exchange Act. For
the avoidance of doubt, and except as otherwise provided herein, Vivo will be deemed to Beneficially Own all of the Warrant Shares
issuable upon exercise of the Warrants held by Vivo or any of its Affiliates at the time of determination.


 



     


     

    




“Board” means the Board
of Directors of the Company.


 


“Business Day” means any
day, other than a Saturday, Sunday or one on which banks are authorized or required by law to be closed in San Francisco, California.


 


“Change of Control Transaction”
has the meaning give to such term in the Company’s Certificate of Designation of Preferences, Rights and Limitations of Series
D Convertible Preferred Stock.


 


“Closing” has the meaning
set forth in the Securities Purchase Agreement.


 


“Competitor” means those
Persons set forth on Exhibit A attached hereto and their respective Subsidiaries and controlled Affiliates; provided, however,
that the Company may, based on the reasonable determination of the Board, update the Persons set forth on Exhibit A attached
hereto not more than once in any consecutive 12-month period to include any other Persons that compete with any material portion
of the Company’s business as reasonably determined by the Board; provided, further, that the total number of Persons set
forth on Exhibit A shall not exceed seven (7).


 


“Convertible Securities”
means all outstanding securities exercisable or exchangeable for, or convertible into, Voting Securities, including the Warrants.


 


“DGCL” means the Delaware
General Corporation Law.


 


“Disqualification Event”
means the “bad actor” disqualifying events described in Rule 506(d)(1)(i)-(viii) promulgated under the Securities Act.


 


“Disqualified Designee”
means any director designee to whom any Disqualification Event is applicable, except for a Disqualification Event as to which Rule
506(d)(2)(ii) or (iii) or (d)(3) is applicable.


 


“Vivo Director” means the
Vivo Nominee who is elected or appointed to the Board.


 


“Vivo Nominee” means the
individual that Vivo is entitled to nominate for election to the Board pursuant to Section 2.1(a).


 


“Election Notice” shall
have the meaning assigned to in Section 4.2(b).


 


“Exchange Act” means the
Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder, as the same may be amended from
time to time.


 


“Group” shall have the
meaning assigned to it in Section 13(d)(3) of the Exchange Act.


 



    2


     

    




“Non-Vivo Directors” means
the members of the Board other than the Vivo Directors.


 


“Ownership Amount” means,
as of the date of the relevant Election Notice, the sum of (A) the number of Shares (on an as-if-converted-to-Common Stock basis,
disregarding for such purpose any conversion limitations thereon) and shares of Common Stock then held by Vivo and its Affiliates,
plus (B) the number of Warrant Shares issuable if the Warrants then held by Vivo and its Affiliates and that have an exercise price
that is greater than the price per Participation Share to be issued in the applicable Post-Closing Issuance were fully exercised
on such date.


 


“Ownership Percentage”
means, as of the date of the relevant Election Notice, a fraction, the numerator of which is the Ownership Amount and the denominator
of which is the total number of outstanding Share Equivalents as of the date of the relevant Election Notice.


 


“Participation Shares”
means the number of Voting Securities or Convertible Securities or any other equity or equity-linked securities (including, for
the avoidance of doubt, convertible debt) proposed to be sold by the Company or one of its Subsidiaries in a Post-Closing Issuance.


 


“Person” means an individual,
partnership, corporation, business trust, joint stock company, trust, unincorporated association, joint venture, limited liability
company or any other entity of whatever nature, and shall include any successor (by merger or otherwise) of such entity.


 


“Post-Closing Issuance”
shall have the meaning assigned to it in Section 4.2(a).


 


“Restricted Shares” means
the Shares, the Warrants and the Warrant Shares.


 


“Rule 144” means Rule 144
under the Securities Act.


 


“Rule 506(d) Related Party”
shall mean with respect to any Person any other Person that is a beneficial owner of such first Person’s securities for purposes
of Rule 506(d) of the Securities Act.


 


“SEC” means the United
States Securities and Exchange Commission.


 


“Securities Act” means
the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder, as the same may be amended from time
to time.


 


“Share Equivalents” means
all outstanding shares of the Common Stock, together with all shares of Common Stock issuable upon exercise, conversion or exchange
of all outstanding Convertible Securities (whether or not then exercisable, convertible or exchangeable), including the Warrant
Shares, that have an exercise, conversion or exchange price that is greater than the price per Participation Share to be issued
in the applicable Post-Closing Issuance.


 


“Shares” shall have the
meaning assigned to it in the preamble.


 



    3


     

    




“Subsidiary” means, with
respect to any party, any corporation, partnership, trust, limited liability company or other non-corporate business enterprise
in which such party (or another Subsidiary of such party) holds stock or other ownership interests representing (A) more that 50%
of the voting power of all outstanding stock or ownership interests of such entity, (B) the right to receive more than 50% of the
net assets of such entity available for distribution to the holders of outstanding stock or ownership interests upon a liquidation
or dissolution of such entity or (C) a general or managing partnership interest in such entity.


 


“Transfer” means, directly
or indirectly, to sell, transfer, assign, pledge, encumber, hypothecate or similarly dispose of (by merger, testamentary disposition,
operation of law or otherwise), either voluntarily or involuntarily, or to enter into any contract, option or other arrangement
or understanding with respect to the sale, transfer, assignment, pledge, encumbrance, hypothecation or similar disposition of (by
merger, testamentary disposition, operation of law or otherwise), any Transfer Restricted Shares.


 


“Transfer Restricted Shares”
means any Shares, shares of Common Stock issued upon conversion of the Shares, Warrants or Warrant Shares.


 


“Voting Securities” means
shares of Common Stock and any other securities of the Company that are permitted by their terms to vote generally in the election
of directors. Except as otherwise provided herein, references to the number or percentage of Voting Securities outstanding or Beneficially
Owned will be deemed to include any Warrant Shares issuable upon exercise of the Warrants at the time of determination.


 


“Warrants” shall have the
meaning assigned to it in the preamble.


 


“Warrant Shares” shall
have the meaning assigned to it in the preamble.


 


Section 1.2.                     
General Interpretive Principles.


 


(a)               
The name assigned to this Agreement and the section captions used herein are for convenience of reference only and shall
not be construed to affect the meaning, construction or effect hereof.


 


(b)              
Unless otherwise specified, the terms “hereof,” “herein” and similar terms refer to this Agreement
as a whole, and references herein to Articles or Sections refer to Articles or Sections of this Agreement.


 


(c)               
For purposes of this Agreement, the words, “include,” “includes” and “including,” when
used herein, shall be deemed in each case to be followed by the words “without limitation.”


 


(d)              
Any action that is required to be taken by the Non-Vivo Directors or any consent that may be given by the Non-Vivo Directors
herein shall require the approval or consent of a majority of the Non-Vivo Directors.


 


(e)               
The parties hereto have participated jointly in the negotiation and drafting of this Agreement. If an ambiguity or question
of intent or interpretation arises, this Agreement will be construed as if drafted jointly by the parties and no presumption or
burden of proof will arise favoring or disfavoring any party because of the authorship of any provision of this Agreement.


 






    4


     

    

ARTICLE
II



GOVERNANCE


 


Section 2.1.                     
Board of Directors.


 


(a)   
Board Representation.


 


(i)           
Following the Closing and for so long as Vivo Beneficially Owns at least 4.5% of the Company’s outstanding
Voting Securities, Vivo shall have the right to nominate one individual for election to the Board (such individual, the “Vivo
Nominee”).


 


(ii)           
In the event that Vivo is no longer entitled to nominate a director to the Board pursuant to Section 2.1(a)(i) above,
Vivo shall promptly cause the then-serving Vivo Director to immediately resign. If any such director is unwilling to resign, Vivo
will take all such actions as are necessary to cause the removal of the director, including voting (or causing to be voted) all
of the Voting Securities Beneficially Owned by it in favor of such removal.


 


(iii)           
For so long as Vivo has the right to nominate a Vivo Nominee for election pursuant to Section 2.1(a)(i), in connection
with each election of directors, subject to Section 2.1(a)(v), the Company shall nominate such Vivo Nominee for election as a director
as part of the management slate that is included in the proxy statement of the Company relating to the election of directors.


 


(iv)           
In the event that any Vivo Director shall cease to serve as a director for any reason (other than the resignation
or removal of such director as a result of Vivo not having the right to nominate a director pursuant to Section 2.1(a)(i)), subject
to Section 2.1(a)(v), Vivo shall have the right to designate another Vivo Nominee to fill the vacancy resulting therefrom. For
the avoidance of doubt, it is understood that the failure of the stockholders of the Company to elect any Vivo Nominee shall not
affect the right of Vivo to designate a Vivo Nominee for election pursuant to Section 2.1(a)(i) in connection with any future election
of directors of the Company.


 


(v)           
Notwithstanding the foregoing, as a condition to any Vivo Nominee’s appointment to the Board and nomination
for election as a director of the Company at the Company’s annual meetings of stockholders:


 


		(A)	Vivo and such Vivo Nominee must in all material respects provide to the Company (1) all information reasonably requested by
the Company that is required to be or customarily disclosed for directors, candidates for directors, and their affiliates in a
proxy statement or other filings under applicable law or regulation or stock exchange rules or listing standards, in each case,
relating to their nomination or election as a director of the Company and (2) information reasonably requested by the Company in
connection with assessing eligibility, independence and other criteria applicable to directors or satisfying compliance and legal
or regulatory obligations, in each case, relating to their nomination or election as a director of the Company, with respect to
Vivo, its Affiliates and the applicable Vivo Nominee, in each case, to the same extent as all other directors of the Company;



 



    5


     

    




		(B)	such Vivo Nominee must be qualified to serve as a director of the Company under the DGCL to the same extent as all other directors
of the Company;



 


		(C)	no Disqualification Event shall be applicable to such Vivo Nomine except, if applicable, for a Disqualification Event as to
which Rule 506(d)(2)(ii) or (iii) or (d)(3) is applicable;



 


		(D)	such Vivo Nominee shall be reasonably acceptable to the Nominating and Governance Committee of the Board; and



 


		(E)	such Vivo Nominee must satisfy the requirements set forth in the Company’s Corporate Governance Guidelines, code of conduct
and securities trading policy, in each case as currently in effect with such changes thereto (or such successor policies) as are
applicable to all other directors, as are adopted in good faith by the Board, and do not by their terms adversely impact any Vivo
Nominee relative to all other directors (provided that, for the avoidance of doubt, no Vivo Nominee shall be required to qualify
as an independent director under applicable stock exchange rules or securities laws and regulations).



 


The Company will make all information
requests pursuant to this Section 2.1(a)(v) in good faith in a timely manner that allows Vivo and the Vivo Nominee a reasonable
amount of time to provide such information, and will cooperate in good faith with Vivo and the Vivo Nominee in connection with
their efforts to provide the requested information.


 


(vi)           
Vivo hereby covenants and agrees (A) not to designate or participate in the designation of any director designee
who, to Vivo’s knowledge, is a Disqualified Designee, (B) that in the event Vivo becomes aware that any individual previously
designated by Vivo is or has become a Disqualified Designee or that a Disqualification Event has become applicable to Vivo or any
of its Rule 506(d) Related Parties, except, if applicable, for a Disqualification Event as to which Rule 506(d)(2)(ii) or (iii)
or (d)(3) is applicable, then Vivo shall notify the Company promptly in writing and as promptly as practicable Vivo shall take
such actions as are necessary to remove any such Disqualified Designee from the Board and designate a replacement designee who
is not a Disqualified Designee, and (C) for so long as there is a Vivo Director, Vivo will comply with the Company’s insider
trading policy as currently in effect with such changes thereto (or such successor policies) as are applicable to all other stockholders
of the Company that have rights to designate or nominate members of the Board.


 



    6


     

    




(b)                    
Identity of the Nominee. The initial Vivo Nominee shall be Frank Kung. The Company confirms that Frank Kung
is reasonably acceptable to the Nominating and Governance Committee of the Board. The Company shall cause the initial Vivo Nominee
to be appointed to the Board on or prior to the date of the first regular or special meeting of the Board occurring after the Closing
and in no event later than November 2, 2017.


 


(c)                     
D&O Indemnification. The Vivo Director shall be eligible to enter into an indemnification agreement consistent
with the form generally entered into with the Company’s officers and directors.


 


(d)                    
Committees. The Vivo Director shall not serve on either of the Compensation Committee, Audit Committee or
Nominating and Governance Committee of the Board and shall not be entitled to serve on any other committee of the Board except
as otherwise agreed by the Vivo Director and the other members of the Board.


 


(e)                     
Board Observer. Following the Closing and for so long as Vivo Beneficially Owns at least 4.5% of the Company’s
outstanding Voting Securities, the Company shall invite a representative of Vivo to attend all meetings of its Board in a nonvoting
observer capacity (the “Vivo Board Observer”) and, in this respect, shall give such representative copies of
all notices, minutes, consents, and other materials that it provides to its directors at the same time and in the same manner as
provided to such directors; provided, however, that such representative shall agree to hold in confidence any non-public
information concerning the financial data, strategic business plans and other non-public proprietary and confidential information
concerning the Company so provided (the “Confidential Information”); provided, that such representative may make disclosure
of such Confidential Information (i) to which the Company gives its prior written consent, (ii) to Vivo and its affiliates, agents
and representatives (including its accountants and attorneys) who agree to preserve the confidentiality thereof, and (iii) in the
event and to the extent required to do so by law, regulation or legal process; and provided further, that the Company may
withhold any Confidential Information and exclude such representative from any meeting or portion thereof if the Company in good
faith determines, after consultation with outside counsel, that access to such Confidential Information or attendance at such meeting
or portion thereof could adversely affect the attorney-client privilege between the Company and its counsel or result in disclosure
of material trade secrets or a material conflict of interest.


 






    7


     

    

ARTICLE
III



TRANSFER RESTRICTIONS


 


Section 3.1.                     
General Transfer Restrictions. The right of Vivo to Transfer any Transfer Restricted Shares Beneficially Owned by Vivo is
subject to the restrictions set forth in this Article III, and no Transfer by Vivo of such Transfer Restricted Shares Beneficially
Owned by Vivo may be affected except in compliance with this Article III. Any attempted Transfer in violation of this Article III
shall be of no effect and null and void, regardless of whether the purported transferee has any actual or constructive knowledge
of the Transfer restrictions set forth in this Article III, and shall not be recorded on the stock transfer books of the Company.


 


Section 3.2.                     
Specific Transfer Restrictions.


 


(a)   
Without the prior approval of the Non-Vivo Directors, Vivo shall not, and shall not permit any of its Affiliates
to:


 


(i)           
Except as permitted under Section 3.3, Transfer any Transfer Restricted Shares to any Person or Group that is or
includes a Competitor; or


 


(ii)           
Except as permitted under Section 3.3, Transfer any Transfer Restricted Shares to any Person or Group during the
one-year period immediately following the Closing.


 


(b)  
Other than with respect to any Transfer permitted by Section 3.3, prior to any Transfer of Transfer Restricted Shares
to any Person or Group, Vivo shall first provide the Company with ten (10) days prior written notice of its intent to Transfer
any Transfer Restricted Shares. Thereafter, Vivo agrees to negotiate in good faith with the Company with respect to the purchase
by the Company or any other third parties introduced to Vivo by the Company of such Transfer Restricted Shares subject to such
proposed Transfer.


 


(c)   
Vivo acknowledges that the Restricted Shares have not been registered under the Securities Act and may not be Transferred
except pursuant to an effective registration statement under the Securities Act or pursuant to an exemption from registration under
the Securities Act. Vivo covenants that the Restricted Shares will only be disposed of pursuant to an effective registration statement
under, and in compliance with the requirements of, the Securities Act or pursuant to an available exemption from the registration
requirements of the Securities Act, and in compliance with any applicable state and foreign securities laws. In connection with
any Transfer of Restricted Shares other than pursuant to an effective registration statement or to the Company, or pursuant to
Rule 144, the Company may require Vivo to provide to the Company an opinion of counsel selected by Vivo and reasonably acceptable
to the Company, the form and substance of which opinion shall be reasonably satisfactory to the Company, to the effect that such
Transfer does not require registration under the Securities Act. Notwithstanding the foregoing, the Company hereby consents to
and agrees to register on the books of the Company and with its transfer agent, without any legal opinion, except to the extent
that the transfer agent requests such legal opinion, any Transfer of Restricted Shares by Vivo to an Affiliate, provided
that the Transfer is effected in accordance with Section 3.3.


 



    8


     

    




(d)  
Vivo agrees to the imprinting, so long as is required by this Section 3.2, of a legend in substantially the
following form on any certificate evidencing any of the Restricted Shares:


 


NEITHER
THIS SECURITY NOR THE SECURITIES INTO WHICH THIS SECURITY IS CONVERTIBLE OR EXERCISABLE HAVE BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR
ASSIGNED (I) IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, OR (B) AN OPINION OF COUNSEL TO THE HOLDER (IF REQUESTED BY THE COMPANY), IN A FORM REASONABLY ACCEPTABLE TO THE COMPANY,
THAT REGISTRATION IS NOT REQUIRED UNDER SAID ACT OR (II) UNLESS SOLD OR ELIGIBLE TO BE SOLD PURSUANT TO RULE 144 UNDER SAID ACT.
NOTWITHSTANDING THE FOREGOING, THE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN OR FINANCING
ARRANGEMENT SECURED BY THE SECURITIES.


 


Certificates evidencing the Restricted Shares shall
not be required to contain such legend or any other legend (i) following any sale of such Restricted Shares pursuant to an
effective registration statement (including the Registration Statement) covering the resale of the Restricted Shares, (ii) following
any sale of such Restricted Shares pursuant to Rule 144 if the holder provides
the Company with a legal opinion reasonably acceptance to the Company to the effect that the Restricted Shares were sold under
Rule 144 or (iii) if the holder provides the Company with a legal
opinion reasonably acceptable to the Company to the effect that the legend is not required under applicable requirements
of the Securities Act. Notwithstanding anything to the contrary in this Agreement or the Securities Purchase Agreement, in the
event of any conflict or inconsistency between any provision of Section 3.2(d), Section 3.3 or Article IV of this Agreement, on
the one hand, and any provision of the Securities Purchase Agreement, on the other hand, whichever provision is more favorable
to Vivo under the circumstances (as determined by Vivo in its sole discretion) will control as between the Company and Vivo.


 


Section 3.3.                     
Permitted Transfers. Vivo may Transfer any or all of the Transfer Restricted Shares held by it (i) to an Affiliate, provided
that, at or prior to the Transfer, such transferee shall have agreed with the Company in writing to be bound by all of the terms
and condition of this Agreement applicable to Vivo, or (ii) in connection with a Change of Control Transaction or Fundamental Transaction
(as such term is defined in the Company’s Certificate of Designation of Preferences, Rights and Limitations of Series D Convertible
Preferred Stock), at the consummation of (and pursuant to the terms of) such transaction.


 






    9


     

    

ARTICLE
IV 


 


SHARE
OWNERSHIP


 


Section 4.1.                     
Standstill.


 


(a)   
Except as provided in Section 4.1(b), from the Closing until the later of (i) three years from the Closing, and
(ii) three months after no Vivo Nominee serves on the Board (the “Standstill Period”), Vivo shall not, nor shall
it permit any Affiliate to, directly or indirectly, without the prior consent of the Company (acting through a resolution of the
Company’s Non-Vivo Directors):


 


(i)           
acquire or agree to acquire, whether by purchase, tender or exchange offer, by forming, joining or otherwise participating
in a partnership, syndicate or other Group, through the use of a derivative instrument or voting agreement, or otherwise, (A) Beneficial
Ownership of additional Voting Securities or Convertible Securities after the Closing that would result in Vivo (together with
its Affiliates and any parties acting as members of a Group with Vivo), having Beneficial Ownership of more than 33.0% in the aggregate
of the shares of Voting Securities outstanding at such time (assuming (1) the exercise of all of then-outstanding Warrants for
the maximum number of shares of Common Stock issuable thereunder, regardless of whether such Warrants are then exercisable, and
(2) the conversion of the Preferred Shares for the maximum number of shares of Common Stock issuable thereunder, regardless of
whether such Preferred Shares are then convertible, which number of shares shall be included in the numerator and denominator for
purposes of determining the percentage of Voting Securities Beneficially Owned by Vivo (together with its Affiliates and any parties
acting as members of a Group with Vivo) for purposes of this clause (A)), except pursuant to Section 4.2 of this Agreement, pursuant
to the exercise of the Warrants, pursuant to the Securities Purchase Agreement or pursuant to the Company’s Certificate of
Designation of Preferences, Rights and Limitations of Series D Convertible Preferred Stock, or (B) any direct or indirect ownership
interest in any indebtedness or debt securities of the Company or any of its Subsidiaries, except pursuant to Section 4.2 of this
Agreement;


 


(ii)           
(A) make, or in any way participate, directly or indirectly, in any “solicitation” of “proxies”
(as such terms are used in the rules of the SEC) to vote Voting Securities, (B) seek to advise or knowingly influence any Person
with respect to the voting of any Voting Securities or (C) deposit any Voting Securities in any voting trust or subject any Voting
Securities to any arrangement or agreement with respect to the voting of any Voting Securities, except for this Agreement;


 


(iii)           
make any public announcement of a proposal or offer (with or without conditions) with respect to any extraordinary
transaction involving Vivo or its Affiliates and the Company including, without limitation, any tender offer, merger, consolidation
or business combination;


 



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(iv)           
effect or seek to effect any recapitalization, reclassification, liquidation or dissolution of the Company;


 


(v)           
publicly disclose any intention, plan or arrangement by Vivo regarding the possibility of any of the events described
in clauses (i) through (iv) above;


 


(vi)           
knowingly take any action that would require either the Company or Vivo under applicable law or the rules of the
principal exchange on which the Company’s Common Stock is then listed or traded to make a public announcement regarding the
possibility of any of the events described in clauses (i) through (iv) above; or


 


(vii)           
enter into any discussions, negotiations, agreements or understandings with any other third Person (excluding Vivo’s
advisors) with respect to any of the foregoing.


 


(b)  
Notwithstanding the foregoing, the restrictions contained in Section 4.1(a) shall not (1) apply with respect
to the designations of the Vivo Nominee and Vivo Board Observer in accordance with this Agreement, (2) prevent a Vivo Director
from taking any action in his or her capacity as a director of the Company, (3) prevent Vivo or any of its Affiliates from voting
its Voting Securities in its discretion, (4) apply to the acquisition of securities in or control of another Person (including
by way of merger or consolidation) or (5) apply to any acquisitions or investments by any bona fide employee benefit plan of Vivo
or its Affiliates. In addition, the restrictions contained in Section 4.1(a) shall not prevent a private communication to the Board
to the extent that such private communication would not reasonably be expected to require a public disclosure prior to any public
announcement by the Company that it (or its Board) has approved or entered into an agreement with respect to a Change of Control
Transaction or Fundamental Transaction.


 


Section 4.2.                     
Preemptive Rights.


 


(a)   
Other than as set forth in Section 4.2(d) and (e), if the Company or any Subsidiary of the Company at any time
shall propose to issue any Voting Securities or Convertible Securities or any other equity or equity-linked securities (including,
for the avoidance of doubt, convertible debt) following the Closing in a capital raising transaction for cash (other than pursuant
to the Securities Purchase Agreement) (a “Post-Closing Issuance”), Vivo shall have the right to purchase for
cash directly from the Company or such Subsidiary up to its Ownership Percentage of such Participation Shares at the same purchase
price as the price for the Participation Shares to be issued; provided, however, that the issuance of securities in connection
with the DSM Financing (as defined in the Securities Purchase Agreement) shall not be considered a Post-Closing Issuance hereunder.


 



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(b)  
With respect to any Post-Closing Issuance, the Company, on behalf of itself or its applicable Subsidiary, will
notify Vivo in writing (the “Notice”) stating (i) its bona fide intention to offer such Participation Securities,
(ii) the number of such Participation Securities to be offered, and (iii) the price and terms, if any, upon which it proposes to
offer such Participation Securities.


 


(c)   
Within thirty (30) business days after giving of the Notice, Vivo may elect to purchase or obtain, at the price
and on the terms specified in the Notice, up to its Ownership Percentage of such Participation Shares. Vivo shall be entitled to
allocate, as among its Affiliates (who agree or have agreed in writing to be bound by the terms of this Agreement), the number
of Participation Shares entitled to be purchased by Vivo pursuant to this Section 4.2. In the event that Vivo elects to exercise
its purchase rights pursuant to this Section 4.2, Vivo shall provide to the Company written notice of such election (the “Election
Notice”) to purchase up to its Ownership Percentage of the Participation Shares hereunder, which notice shall (i) certify
the Ownership Amount as of the date of the Election Notice, (ii) specify the number of Participation Shares to be purchased by
Vivo and its Affiliates (not to exceed Vivo’s Ownership Percentage of the Participation Shares, the “Specified Number”),
and (iii) the allocation of such Participation Shares among Vivo and its Affiliates. Vivo shall, or shall cause its Affiliates
(as applicable) to, purchase, and the Company shall, or shall cause its applicable Subsidiary to, issue and sell to Vivo and its
Affiliates (as applicable), the Specified Number of the Participation Shares concurrently with the related Post-Closing Issuance
by the Company or its applicable Subsidiary.


 


(d)  
In the event that the Post-Closing Issuance which gave rise to the exercise by Vivo of its purchase rights pursuant
to this Section 4.2 shall be terminated or abandoned by the Company without the issuance of any securities, then the purchase rights
of Vivo pursuant to this Section 4.2 shall also terminate as to such proposed Post-Closing Issuance (but not any subsequent or
future issuance), and any funds in respect thereof paid to the Company by Vivo shall be refunded in full.


 


(e)   
Notwithstanding the foregoing, the provisions of this Section 4.2 shall not apply to, and Vivo shall not have
any purchase rights with respect to, any of the following types of Post-Closing Issuances by the Company or any of its Subsidiaries:


 


(i)           
any Post-Closing Issuance of Voting Securities or Convertible Securities to officers, employees, directors or consultants
of the Company in connection with such Person’s employment or consulting arrangements with the Company or the service of
such person as a director;


 


(ii)           
any Post-Closing Issuance of Voting Securities or Convertible Securities (i) in any business combination or acquisition
transaction involving the Company or any of its Subsidiaries or (ii) in connection with the incurrence of indebtedness by the Company
or any of its Subsidiaries (provided that such indebtedness does not constitute a Convertible Security);


 


(iii)           
any Post-Closing Issuance of Voting Securities or Convertible Securities in connection with any stock split, stock
dividend or recapitalization approved by the Board (so long as all holders of the same class or series of Voting Securities is
treated equally with all other holders of such class or series of Voting Securities); or


 



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(iv)           
any Post-Closing Issuance of Voting Securities pursuant to a public offering registered under the Securities Act;
or


 


(v)           
any Post-Closing Issuance of Voting Securities or Convertible Securities to any Person (or any Affiliate of a Person),
which is an operating company or an owner of an asset in a business synergistic with the Company’s business as determined
in good faith by the Board, to induce such Person to enter into any joint venture or other strategic or commercial relationship
with the Company or any of its Subsidiaries that provides to the Company additional benefits in addition to the investment of funds,
as determined in good faith by the Non-Vivo Directors, but shall not include a transaction in which the Company or any of its Subsidiaries
is issuing securities primarily for the purpose of raising capital or to a Person whose primary business is investing in securities
of other Persons.


 


(f)   
The Company may, during the seventy-five (75) day period following the expiration of the period provided in Section
4.2(c) hereof, offer the remaining unsubscribed portion of such Participation Securities to any Person or Persons at a price not
less than, and upon terms no more favorable to the offeree than, those specified in the Notice. If the Company does not consummate
the sale of such Participation Securities, or enter into a definitive agreement for the sale of such Participation Securities,
within such period, or if the Company enters into such a definitive agreement and such agreement is not consummated within seventy-five
(75) days of the execution thereof, the purchase right pursuant to this Section 4.2 shall be deemed to be revived and no such
Participation Securities shall be offered unless first reoffered to Vivo in accordance herewith.


 


ARTICLE
V

REGISTRATION RIGHTS


 


The Company hereby grants to each of the
Holders (as defined below) the registration rights set forth in this Article V, with respect to the Registrable Securities (as
defined below) owned by such Holders.


 


Section 5.1.                     
Certain Definitions. As used in this Article V:


 


(a)   
“Effective Date” means the date that the Initial Registration Statement has been declared
effective by the SEC.


 


(b)  
“Effectiveness Deadline” means December 22, 2017.


 


(c)   
“Filing Deadline” means November 7, 2017.


 


(d)  
“Holder” (collectively, “Holders”) means (i) Vivo and (ii) any Affiliate
of Vivo that Vivo designates in writing as a Holder, in each case to the extent holding Registrable Securities, securities exercisable
or convertible into Registrable Securities or securities exercisable for securities convertible into Registrable Securities.


 



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(e)   
“Prospectus” means the prospectus included in any Registration Statement, all amendments and
supplements to such prospectus, including post-effective amendments, and all other material incorporated by reference in such prospectus.


 


(f)   
“register”, “registered” and “registration” refer to
a registration effected by filing with the SEC a Registration Statement in compliance with the Securities Act, and the declaration
or ordering by the SEC of the effectiveness of such Registration Statement.


 


(g)  
“Registrable Securities” means (i) Underlying Shares held by, or issuable to, Holders and
(ii) any shares of Voting Securities issued as (or issuable upon) a stock split, stock dividend or other distribution with respect
to, or in exchange or in replacement of, such Registrable Securities set forth in clause (i), in each case, until the earliest
to occur of (A) the date on which a Registration Statement covering such securities has been declared effective by the SEC and
such security has been disposed of pursuant to such effective Registration Statement, (B) the date on which such security is sold
pursuant to Rule 144, (C) the date on which such security ceases to be outstanding or (D) the date on which the Holder thereof,
together with its Affiliates, is able to dispose of all of its Registrable Securities in any 90 day period pursuant to Rule 144
(or any similar or analogous rule promulgated under the Securities Act).


 


(h)  
“Registration Statement” means a registration statement or registration statements of the
Company filed under the Securities Act covering the Registrable Securities.


 


(i)    
“Required Registration Amount” means the lesser of (i) 100% of the sum of the maximum number
of Underlying Shares issued and issuable as of the Trading Day immediately preceding the applicable date of determination or (ii)
such other amount as may be required by the staff of the SEC pursuant to Rule 415 with any cutback applied pro rata to all Holders.


 


(j)                      
“Underlying Shares” means the Warrant Shares, the Common Shares and the shares of Common Stock
issuable upon conversion of the Preferred Shares.


 


Section 5.2.                     
Registration


 


(a)   
(i)Initial Mandatory Registration. The Company shall use reasonable efforts to prepare, and, as soon
as practicable, but in no event later than the Filing Deadline, file with the SEC a Registration Statement on Form S-3 covering
the resale of all of the Registrable Securities (the “Initial Registration Statement”). The Initial Registration
Statement prepared pursuant hereto shall register for resale at least the number of shares of Common Stock equal to the total number
of then outstanding Registrable Securities determined as of the date the Initial Registration Statement is initially filed with
the SEC. The Company shall use its reasonable best efforts to have the Initial Registration Statement declared effective by the
SEC as soon as practicable, but in no event later than the Initial Effectiveness Deadline. The Company shall use its reasonable
efforts to file with the SEC in accordance with Rule 424 under the Securities Act the final prospectus to be used in connection
with sales pursuant to such Initial Registration Statement by 9:30 am on the Business Day following the Effective Date, but in
any case no later than the deadline required by Rule 424.


 



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(ii)           
Additional Registrations. Notwithstanding anything herein to the contrary, to the extent the staff of the
SEC does not permit all of the Registrable Securities to be registered on the Initial Registration Statement, the Company shall
file additional Registration Statements successively trying to register on each such Registration Statement the maximum number
of remaining Registrable Securities until all of the Registrable Securities have been registered for resale. Each such additional
Registration Statement prepared pursuant hereto shall register for resale at least that number of shares of Common Stock equal
to the Additional Registrable Securities determined as of the date such Additional Registration Statement is initially filed with
the SEC. The Company shall use its reasonable efforts to have each such additional Registration Statement declared effective by
the SEC as soon as practicable. The Company shall file with the SEC in accordance with Rule 424 under the Securities Act the final
prospectus to be used in connection with sales pursuant to such additional Registration Statement by 9:30 am on the Business Day
following the effective date of such Registration Statement, but in any case no later than the deadline required by Rule 424.


 


(iii)           
Underwritten Registrations. With respect to any of the registrations contemplated by this Section 5.2(a),
VIVO may request that up to three such registrations provide for an underwritten offering of the Registrable Securities. In connection
with any such underwritten offering, the right of any Holder to registration pursuant to this Section 5.2(a)(iv) shall be conditioned
upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in
the underwriting to the extent provided herein in subject to the limitations expressed in this Section 5.2. All Holders proposing
to distribute their Registrable Securities through such underwriting shall, together with any other parties distributing their
securities through such underwriting, enter into an underwriting agreement in customary form with the underwriter or underwriters
selected for such underwriting by the Company. Notwithstanding any other provision of this Section 5.2, if the underwriter determines
that marketing factors require a limitation of the number of shares to be underwritten, the underwriter may limit the number of
Registrable Securities to be included in the registration and underwriting.


 


(iv)           
Subject to the provisions of this Section 5.2 and further subject to the availability of a Registration Statement
on Form S-3 (or any successor form thereto) to the Company pursuant to the Securities Act and the rules and interpretations of
the SEC, the Company will use its reasonable efforts to keep the Initial Registration Statement (or any replacement Registration
Statement) continuously effective until the earlier of: (A) the date on which all Registrable Securities covered by the Registration
Statement have been sold thereunder in accordance with the plan and method of distribution disclosed in the prospectus included
in the Registration Statement and (B) there otherwise cease to be any Registrable Securities.


 



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(v)           
Allocation of Registrable Securities. The initial number of Registrable Securities included in any Registration
Statement and any increase or decrease in the number of Registrable Securities included therein shall be allocated pro rata among
the Holders based on the number of Registrable Securities held by each Holder at the time the Registration Statement covering such
initial number of Registrable Securities or increase or decrease thereof is declared effective by the SEC. In the event that a
Holder sells or otherwise transfers any of such Holder’s Registrable Securities, each transferee that becomes a Holder shall
be allocated a pro rata portion of the then remaining number of Registrable Securities included in such Registration Statement
for such transferor. Any shares of Common Stock included in a Registration Statement and which remain allocated to any Person which
ceases to hold any Registrable Securities covered by such Registration Statement shall be allocated to the remaining Holders, pro
rata based on the number of Registrable Securities then held by such Holders which are covered by such Registration Statement.


 


(b)  
Suspension of Filing or Registration. If the Company shall furnish to the Holders a certificate signed
by the Chief Executive Officer or Chief Financial Officer of the Company, stating that the filing, effectiveness or continued use
of a Registration Statement would require the Company to make an Adverse Disclosure, then the Company shall have a period of not
more than 75 days (or such longer period as Vivo shall consent to in writing) within which to delay the filing or effectiveness
of such Registration Statement or, in the case of a Registration Statement that has been declared effective, to suspend the use
by Holders of such Registration Statement (in each case, a “Shelf Suspension”); provided, however,
that, unless consented to in writing by the Vivo, the Company shall not be permitted to exercise a Suspension more than twice during
any 12-month period for each Shelf Registration Statement. In the case of a Shelf Suspension that occurs after the effectiveness
of a Registration Statement, the Holders agree to suspend use of the applicable Prospectus in connection with any sale or purchase
of, or offer to sell or purchase, Registrable Securities, upon receipt of the notice referred to above. The Company shall immediately
notify the Holders upon the termination of any Shelf Suspension, and (i) in the case of a Registration Statement that has not been
declared effective, shall promptly thereafter file a Registration Statement and use its reasonable best efforts to have such Registration
Statement declared effective under the Securities Act and (ii) in the case of an effective Registration Statement, shall amend
or supplement the Prospectus, if necessary, so it does not contain any untrue statement or omission and furnish to the Holders
such numbers of copies of the Prospectus as so amended or supplemented as the Holders may reasonably request. The Company agrees,
if necessary, to supplement or make amendments to the applicable Registration Statement, if required by the registration form used
by the Company for the shelf registration or by the instructions applicable to such registration form or by the Securities Act
or the rules or regulations promulgated thereunder.


 


(c)   
The Company shall use its commercially reasonable efforts to take all actions reasonably necessary to ensure
that the transactions contemplated herein are effected as so contemplated in Section 5.2(a) hereof, and to submit to the SEC,
within five Business Days after the Company learns that no review of a Registration Statement will be made by the staff of the
SEC or that the staff has no further comments on a Shelf Registration Statement, as the case may be, a request for acceleration
of effectiveness (or post effective amendment, if applicable) of such Registration Statement to a time and date not later than
48 hours after the submission of such request.


 



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(d)  
Any reference herein to a registration statement or prospectus as of any time shall be deemed to include any
document incorporated, or deemed to be incorporated, therein by reference as of such time and any reference herein to any post-effective
amendment to a registration statement as of any time shall be deemed to include any document incorporated, or deemed to be incorporated,
therein by reference as of such time. Any reference to a prospectus as of any time shall include any supplement thereto, preliminary
prospectus, or any free writing prospectus in respect thereof.


 


(e)   
In connection with the filing of a Registration Statement, the Company shall:


 


(i)           
prepare and file with the SEC within the time periods specified in Section 5.2(a), a Registration Statement
on any form which may be utilized by the Company and which shall register all of the Registrable Securities for resale by the holders
thereof in accordance with such method or methods of disposition (but which shall not include an underwritten offering as to which
the Company needs to assist) as may be specified by Vivo and use reasonable best efforts to cause such Registration Statement to
become effective as soon as reasonably practicable but in any case within the time periods specified in Section 5.2(a);


 


(ii)           
as soon as reasonably practicable prepare and file with the SEC such amendments and supplements to such Registration
Statement (including without limitation, any required post effective amendments) and the prospectus included therein as may be
necessary to effect and maintain the effectiveness of such Registration Statement for the period specified in Section 5.2(a)
hereof and as may be required by the applicable rules and regulations of the SEC and the instructions applicable to the form of
such Registration Statement;


 


(iii)           
comply with the provisions of the Securities Act with respect to the disposition of all of the Registrable Securities
covered by such Registration Statement in accordance with the intended methods of disposition by Vivo provided for in such Registration
Statement;


 


(iv)           
provide Vivo and its legal counsel (“Legal Counsel”) a reasonable opportunity to participate in
the preparation of such Registration Statement, each prospectus included therein or filed with the SEC and each amendment or supplement
thereto (but not including any documents incorporated by reference), in each case subject to customary confidentiality restrictions,
and give reasonable consideration to any comments Legal Counsel provides with respect to any Shelf Registration Statement
or amendment or supplement thereto. The Company shall furnish to Legal Counsel copies of any correspondence from the SEC or the
staff of the SEC to the Company or its representatives relating to any Registration Statement;


 



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(v)           
promptly notify Vivo (A) when such Registration Statement or the Prospectus included therein or any prospectus
amendment or supplement or post-effective amendment has been filed, and, with respect to such Registration Statement or any post-effective
amendment, when the same has become effective, (B) of any comments by the SEC with respect thereto or any request by the SEC
for amendments or supplements to such Registration Statement or prospectus or for additional information, (C) of the issuance
by the SEC of any stop order suspending the effectiveness of such Registration Statement or the initiation or threatening of any
proceedings for that purpose, (D) of the receipt by the Company of any notification with respect to the suspension of the
qualification of the Registrable Securities for sale in any jurisdiction or the initiation or threatening of any proceeding for
such purpose, or (E) if at any time when a prospectus is required to be delivered under the Securities Act, that such Registration
Statement, prospectus, prospectus amendment or supplement or post-effective amendment does not conform in all material respects
to the applicable requirements of the Securities Act and the rules and regulations of the SEC thereunder or contains an untrue
statement of a material fact or omits to state any material fact required to be stated therein or necessary to make the statements
therein not misleading in light of the circumstances then existing; and


 


(vi)           
in the event that Form S-3 is not available for the registration of the resale of Registrable Securities hereunder,
the Company shall (i) register the resale of the Registrable Securities on another appropriate form reasonably acceptable
to Vivo and (ii) undertake to register the Registrable Securities on Form S-3 as soon as such form is available, provided
that the Company shall maintain the effectiveness of the Registration Statement then in effect until such time as a Registration
Statement on Form S-3 covering the Registrable Securities has been declared effective by the SEC.


 


(f)   
In connection with a shelf registration, the Company may require each Holder whose Registrable Securities are
covered by the shelf registration, to furnish to the Company such information regarding the Holder, including, without limitation,
its intended method of distribution of Registrable Securities as may be required in order to comply with the Securities Act. The
Holder agrees to notify the Company as promptly as practicable of any inaccuracy or change in information previously furnished
by the Holder to the Company or of the occurrence of any event in either case that could cause the prospectus to contain an untrue
statement of a material fact regarding the Holder or its intended method of disposition of such Registrable Securities or omits
to state any material fact regarding the Holder or its intended method of disposition of such Registrable Securities required to
be stated therein or necessary to make the statements therein not misleading in light of the circumstances then existing, and promptly
to furnish to the Company any additional information required to correct and update any previously furnished information or required
so that such prospectus shall not contain, with respect to the Holder or the disposition of such Registrable Securities, an untrue
statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements
therein not misleading in light of the circumstances then existing. If the Holder fails to provide to the Company any information
required to be provided pursuant to this Section 5.2 after the Holder became aware of the inaccuracy, omission or required
change, the Company may suspend the use of the Registration Statement and the prospectus contained therein until such time as the
Holder provides the required information to the Company.


 



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Section 5.3.                     
Piggyback Registration.


 


(a)   
Company Registration. If at any time or from time to time the Company shall determine to register any
of its equity securities, either for its own account or for the account of security holders (other than (1) in a registration relating
solely to employee benefit plans, (2) a registration on Form S-4 or S-8 (or such other similar successor forms then in effect under
the Securities Act), (3) a primary registration of securities under Rule 415 of the Securities Act, (4) a registration
pursuant to which the Company is offering to exchange its own securities, (5) a registration statement relating solely to dividend
reinvestment or similar plans, (6) a resale shelf registration statement relating solely to debt securities of the Company that
are convertible into Common Stock and the underlying shares of Common Stock or (7) a registration pursuant to Section 5.2), the
Company will:


 


(i)           
promptly (but in no event less than 10 days before the effective date of the relevant Registration Statement) give
to each Holder written notice thereof; and


 


(ii)           
include in such registration (and any related qualification under state securities laws or other compliance), and
in any underwriting involved therein, all the Registrable Securities specified in a written request or requests, made within 5
days after receipt of such written notice from the Company, by any Holder or Holders, subject, in each case, to the limitations
expressed in Section 5.2 and except as set forth in Section 5.3(b) below.


 


(b)  
Underwriting. If the registration of which the Company gives notice is for a registered public offering
involving an underwriting, the Company shall so advise the Holders as a part of the written notice given pursuant to Section 5.3(a)(i).
In such event the right of any Holder to registration pursuant to this Section 5.3 shall be conditioned upon such Holder’s
participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent
provided herein in subject to the limitations expressed in Section 5.2. All Holders proposing to distribute their Registrable
Securities through such underwriting shall, together with the Company and the other parties distributing their securities through
such underwriting, enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such
underwriting by the Company. Notwithstanding any other provision of this Section 5.3, if the underwriter determines that marketing
factors require a limitation of the number of shares to be underwritten, the underwriter may limit the number of Registrable Securities
to be included in the registration and underwriting, subject to the terms of this Section 5.3. The Company shall so advise all
holders of the Company’s securities that would otherwise be registered and underwritten pursuant hereto, and the number of
shares of such securities, including Registrable Securities, that may be included in the registration and underwriting shall be
allocated first to the Company and second to the Holders and any other holders with registration rights on a pro
rata basis based on the total number of Registrable Securities held by the Holders and such other holders. No such reduction shall
(i) reduce the securities being offered by the Company for its own account to be included in the registration and underwriting,
or (ii) subject to the limitations expressed in Section 5.2, reduce the amount of securities of the selling Holders included
in the registration below twenty-five percent (25%) of the total amount of securities included in such registration by all selling
stockholders. No securities excluded from the underwriting by reason of the underwriter’s marketing limitation shall be included
in such registration. For the avoidance of doubt, nothing in this Section 5.3(b) is intended to diminish the number of securities
to be included by the Company in the underwriting.


 



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(c)   
Right to Terminate Registration. The Company shall have the right to terminate or withdraw any registration
initiated by it under this Section 5.3 prior to the effectiveness of such registration whether or not any Holder has elected to
include securities in such registration.


 


Section 5.4.                     
Expenses of Registration. All expenses incurred in connection with all registrations effected pursuant to Sections 5.2 and
5.3, including all registration, filing and qualification fees (including state securities law fees and expenses), printing expenses,
escrow fees, fees and disbursements of counsel for the Company; provided, however, that the Company shall not be
required to pay the fees of Legal Counsel, stock transfer taxes or underwriters’ discounts or selling commissions relating
to Registrable Securities.


 


Section 5.5.                     
Obligations of the Company. Whenever required under this Article V to effect the registration of any Registrable Securities,
the Company shall (in addition to the requirements set forth in Section 5.2(e) with respect to a Registration Statement), as expeditiously
as reasonably possible:


 


(a)   
prepare and file with the SEC such amendments and supplements to such Registration Statement and the prospectus
used in connection with such Registration Statement as may be necessary to keep such Registration Statement effective and to comply
with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration statement
in accordance with the intended methods of disposition by sellers thereof set forth in such registration statement;


 


(b)  
permit any Holder which Holder, in the reasonable judgment of the Company, if deemed to be a controlling person
of the Company, to participate in good faith in the preparation of such Registration Statement and to cooperate in good faith to
include therein material, furnished to the Company in writing, that in the reasonable judgment of the Company should be included;


 


(c)   
furnish to the Holders such numbers of copies of a prospectus, including all exhibits thereto and documents incorporated
by reference therein and a preliminary prospectus, in conformity with the requirements of the Securities Act, and such other documents
as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them;


 



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(d)  
in the event of any underwritten public offering, enter into and perform its obligations under an underwriting
agreement, in usual and customary form, with the managing underwriter(s) of such offering. Each Holder participating in such underwriting
shall also enter into and perform its obligations under such an agreement;


 


(e)   
notify each Holder of Registrable Securities covered by such Registration Statement as soon as reasonably practicable
after notice thereof is received by the Company of any written comments by the SEC or any request by the SEC or any other federal
or state governmental authority for amendments or supplements to such Registration Statement or such prospectus or for additional
information;


 


(f)   
notify each Holder of Registrable Securities covered by such Registration Statement, at any time when a prospectus
relating thereto is required to be delivered under the Securities Act, of the happening of any event as a result of which the prospectus
included in such Registration Statement, as then in effect, includes an untrue statement of a material fact or omits to state a
material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances
then existing;


 


(g)  
notify each Holder of Registrable Securities covered by such Registration Statement as soon as reasonably practicable
after notice thereof is received by the Company of the issuance by the SEC of any stop order suspending the effectiveness of such
Registration Statement or any order by the SEC or any other regulatory authority preventing or suspending the use of any preliminary
or final prospectus or the initiation or threatening of any proceedings for such purposes, or any notification with respect to
the suspension of the qualification of the Registrable Securities for offering or sale in any jurisdiction or the initiation or
threatening of any proceeding for such purpose;


 


(h)  
use its reasonable efforts to prevent the issuance of any stop order suspending the effectiveness of any Registration
Statement or of any order preventing or suspending the use of any preliminary or final prospectus and, if any such order is issued,
to obtain the withdrawal of any such order as soon as practicable;


 


(i)    
in the case of an underwritten offering, make available for inspection, at the Company's headquarters during
normal business hours, by each Holder including Registrable Securities in such registration, any underwriter participating in any
distribution pursuant to such registration, and any attorney, accountant or other agent retained by such Holder or underwriter,
all financial and other records, pertinent corporate documents and properties of the Company, as such parties may reasonably request,
and cause the Company’s officers, directors and employees to supply all information reasonably requested by any such Holder,
underwriter, attorney, accountant or agent in connection with such Registration Statement;


 



    21


     

    




(j)    
use its reasonable efforts to register or qualify, and cooperate with the Holders of Registrable Securities covered
by such Registration Statement, the underwriters, if any, and their respective counsel, in connection with the registration or
qualification of such Registrable Securities for offer and sale under the securities or “blue sky” laws of each state
and other jurisdiction of the United States as any such Holder or underwriters, if any, or their respective counsel reasonably
request in writing, and do any and all other things reasonably necessary or advisable to keep such registration or qualification
in effect for such period as required by Section 5.2(a), as applicable; provided that the Company shall not be required
to qualify generally to do business in any jurisdiction where it is not then so qualified or take any action which would subject
it to taxation or general service of process in any such jurisdiction where it is not then so subject;


 


(k)  
in the case of an underwritten offering, obtain for delivery to the underwriters, if any, an opinion or opinions
from counsel for the Company, dated the effective date of the Registration Statement or, in the event of an underwritten offering,
the date of the closing under the underwriting agreement, in customary form, scope and substance, which opinions shall be reasonably
satisfactory to such underwriters and their respective counsel;


 


(l)    
in the case of an underwritten offering, obtain for delivery to the Company and the underwriters, a cold comfort
letter from the Company’s independent certified public accountants in customary form and covering such matters of the type
customarily covered by cold comfort letters as managing underwriter or underwriters reasonably request, dated the date of execution
of the underwriting agreement and brought down to the closing under the underwriting agreement;


 


(m)
       use its reasonable efforts to list the Registrable Securities covered by such Registration
Statement with any securities exchange on which the Common Stock is then listed;


 


(n)  
provide and cause to be maintained a transfer agent and registrar for all Registrable Securities covered by the
applicable Registration Statement from and after a date not later than the effective date of such Registration Statement;


 


(o)  
cooperate with Holders including Registrable Securities in such registration and the underwriters, if any, to
facilitate the timely preparation and delivery of certificates representing Registrable Securities to be sold, such certificates
to be in such denominations and registered in such names as such Holders or the managing underwriters may request at least two
Business Days prior to any sale of Registrable Securities; and


 


(p)  
use its reasonable efforts to comply with all applicable securities laws and make available to its Holders, as
soon as reasonably practicable, an earnings statement satisfying the provisions of Section 11(a) of the Securities Act and the
rules and regulations promulgated thereunder.


 


Section 5.6.                     
Indemnification.


 



    22


     

    




(a)   
The Company will, and does hereby undertake to, indemnify and hold harmless each Holder of Registrable Securities,
each of such Holder’s officers, directors, employees, partners and agents, and each Person controlling such Holder, with
respect to any registration, qualification or compliance effected pursuant to this Article V, and each underwriter, if any, and
each Person who controls any underwriter, of the Registrable Securities held by or issuable to such Holder, against all claims,
losses, damages and liabilities (or actions in respect thereto) to which they may become subject under the Securities Act, the
Exchange Act, or other federal or state law arising out of or based on (A) any untrue statement (or alleged untrue statement) of
a material fact contained in any prospectus, offering circular or other similar document (including any related Registration Statement,
notification, or the like) incident to any such registration, qualification or compliance, or based on any omission (or alleged
omission) to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading
in light of the circumstances in which they were made, (B) any violation or alleged violation by the Company of any federal, state
or common law rule or regulation applicable to the Company in connection with any such registration, qualification or compliance,
or (C) any failure to register or qualify Registrable Securities in any state where the Company or its agents have affirmatively
undertaken or agreed in writing that the Company (the undertaking of any underwriter chosen by the Company being attributed to
the Company) will undertake such registration or qualification on behalf of the Holders of such Registrable Securities (provided
that in such instance the Company shall not be so liable if it has undertaken its reasonable efforts to so register or qualify
such Registrable Securities) and will reimburse, as incurred, each such Holder, each such underwriter and each such director, officer,
partner, agent and controlling person, for any legal and any other expenses reasonably incurred in connection with investigating
or defending any such claim, loss, damage, liability or action; provided that the Company will not be liable in any such
case to the extent that any such claim, loss, damage, liability or expense arises out of or is based on any untrue statement or
omission made in reliance and in conformity with written information furnished to the Company by such Holder or underwriter expressly
for use therein.


 


(b)  
Each Holder will, and if Registrable Securities held by or issuable to such Holder are included in such registration,
qualification or compliance pursuant to this Article V, does hereby undertake to indemnify and hold harmless the Company, each
of its directors, employees, agents and officers, and each Person controlling the Company, each underwriter, if any, and each Person
who controls any underwriter, of the Company’s securities covered by such a Registration Statement, and each other Holder,
each of such other Holder’s officers, partners, directors and agents and each Person controlling such other Holder, against
all claims, losses, damages and liabilities (or actions in respect thereof) arising out of or based on any untrue statement (or
alleged untrue statement) of a material fact contained in any such Registration Statement, prospectus, offering circular or other
document, or any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to
make the statements therein not misleading in light of the circumstances in which they were made, and will reimburse, as incurred,
the Company, each such underwriter, each such other Holder, and each such director, officer, employee, agent, partner and controlling
Person of the foregoing, for any legal or any other expenses reasonably incurred in connection with investigating or defending
any such claim, loss, damage, liability or action, in each case to the extent, but only to the extent, that such untrue statement
(or alleged untrue statement) or omission (or alleged omission) was made in such Registration Statement, prospectus, offering circular
or other document, in reliance upon and in conformity with written information furnished to the Company by such Holder expressly
for use therein; provided, however, that the liability of each Holder hereunder shall be limited to the net proceeds
received by such Holder from the sale of securities under such Registration Statement. It is understood and agreed that the indemnification
obligations of each Holder pursuant to any underwriting agreement entered into in connection with any Registration Statement shall
be limited to the obligations contained in this subsection 5.6(b).


 



    23


     

    




(c)   
Each party entitled to indemnification under this Section 5.6 (the “Indemnified Party”) shall
give notice to the party required to provide such indemnification (the “Indemnifying Party”) of any claim as
to which indemnification may be sought promptly after such Indemnified Party has actual knowledge thereof, and shall permit the
Indemnifying Party to assume the defense of any such claim or any litigation resulting therefrom; provided that counsel
for the Indemnifying Party, who shall conduct the defense of such claim or litigation, shall be subject to approval by the Indemnified
Party (whose approval shall not be unreasonably withheld) and the Indemnified Party may participate in such defense at the Indemnifying
Party’s expense if representation of such Indemnified Party would be inappropriate due to actual or potential differing interests
between such indemnified party and any other party represented by such counsel in such proceeding; and provided further
that the failure of any Indemnified Party to give notice as provided herein shall not relieve the Indemnifying Party of its obligations
under this Article V, except to the extent that such failure to give notice shall materially adversely affect the Indemnifying
Party in the defense of any such claim or any such litigation. An Indemnifying Party, in the defense of any such claim or litigation,
may, without the consent of each Indemnified Party, consent to entry of any judgment or enter into any settlement that includes
as an unconditional term thereof the giving by the claimant or plaintiff therein, to such Indemnified Party, of a release from
all liability with respect to such claim or litigation.


 


(d)  
In order to provide for just and equitable contribution in case indemnification is prohibited or limited by law,
the Indemnifying Party, in lieu of indemnifying such Indemnified Party, shall contribute to the amount paid or payable by such
Indemnified Party as a result of such losses, claims, damages or liabilities in such proportion as is appropriate to reflect the
relative fault of the Indemnifying Party and Indemnified Party in connection with the actions which resulted in such losses, claims,
damages or liabilities, as well as any other relevant equitable considerations. The relative fault of such Indemnifying Party and
Indemnified Party shall be determined by reference to, among other things, whether any action in question, including any untrue
or alleged untrue statement of material fact or omission or alleged omission to state a material fact, has been made by, or relates
to information supplied by, such Indemnifying Party or Indemnified Party, and such party’s relative intent, knowledge, access
to information and opportunity to correct or prevent such actions; provided, however, that, in any case, (i) no Holder
will be required to contribute any amount in excess of the public offering price of all securities offered by it pursuant to such
Registration Statement less all underwriting fees and discounts and (ii) no Person guilty of fraudulent misrepresentation (within
the meaning of Section 11(f) of the Securities Act) will be entitled to contribution from any Person who was not guilty of such
fraudulent misrepresentation.


 



    24


     

    




Section 5.7.                     
Information by Holder. The Holder or Holders of Registrable Securities included in any registration shall furnish to the
Company such information regarding such Holder or Holders and the distribution proposed by such Holder or Holders as the Company
may reasonably request in writing and as shall be required in connection with any registration, qualification or compliance referred
to in this Article V.


 


Section 5.8.                     
Transfer of Registration Rights. The rights, contained in Sections 5.2 and 5.3 hereof, to cause the Company to register
the Registrable Securities, may be assigned or otherwise conveyed by Vivo pursuant to a transfer not prohibited by Section 3.2.


 


Section 5.9.                     
Delay of Registration. No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying
any such registration as the result of any controversy that might arise with respect to the interpretation or implementation of
this Article V.


 


Section 5.10.                 
Termination of Registration Rights. In addition to any termination of this Agreement in accordance with Section 6.1 hereof,
the rights of Vivo to cause the Company to register securities under Article V hereof shall terminate on the date when there no
longer remaining any Registrable Securities.


 


ARTICLE
VI 


 


TERMINATION


 


Section 6.1.                     
Termination. This Agreement shall terminate and be of no further force and effect upon and after the Company’s consummation
of a Change of Control; provided, however, that such termination shall not waive or release any party from any liability for such
party’s willful breach of this Agreement occurring prior to such termination.


 


ARTICLE
VII



MISCELLANEOUS


 


Section 7.1.                     
Entire Agreement. This Agreement (together with the Securities Purchase Agreement, the Warrants and the Company’s
Certificate of Designation of Preferences, Rights and Limitations of Series D Convertible Preferred Stock) constitutes the entire
understanding and agreement between the parties as to the matters covered herein and supersedes and replaces any prior understanding,
agreement or statement of intent, in each case, written or oral, of any and every nature with respect thereto.


 


Section 7.2.                     
Specific Performance. The parties hereto agree that the obligations imposed on them in this Agreement are special, unique
and of an extraordinary character, and that, in the event of breach or threatened breach by any party, damages would not be an
adequate remedy and each of the other parties shall be entitled to specific performance and injunctive and other equitable relief
in addition to any other remedy to which it may be entitled, at law or in equity; and the parties hereto further agree to waive
any requirement for the securing or posting of any bond in connection with the obtaining of any such injunctive or other equitable
relief.


 



    25


     

    




Section 7.3.                     
Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the State of New York applicable
to contracts entered into and performed entirely within such state, without regard to conflict of laws principles.


 


Section 7.4.                     
Amendment and Waiver.


 


(a)   
This Agreement may be amended or modified, and any provision hereof may be waived, in whole or in part, at any
time pursuant to an agreement in writing executed by the Company and Vivo.


 


(b)  
Any failure by any party at any time to enforce any of the provisions of this Agreement shall not be construed
a waiver of such provision or any other provisions hereof.


 


Section 7.5.                     
Binding Effect. Except as otherwise expressly provided herein, the provisions hereof shall inure to the benefit of, and
be binding upon, the parties’ successors and permitted assigns.


 


Section 7.6.                     
Notices. Any and all notices or other communications or deliveries required or permitted to be provided hereunder shall
be in writing and shall be deemed given and effective on the earliest of (a) the date of transmission, if such notice or communication
is delivered via facsimile or email at the facsimile number or email address specified in this Section prior to 6:30 p.m. (Pacific
Time) on a Business Day, (b) the next Business Day after the date of transmission, if such notice or communication is delivered
via facsimile or email at the facsimile number or email address specified in this Section on a day that is not a Business Day or
later than 6:30 p.m. (Pacific Time) on any Business Day, (c) the Business Day following the date of deposit with a nationally
recognized overnight courier service, or (d) upon actual receipt by the party to whom such notice is required to be given.
The addresses, facsimile numbers and email addresses for such notices and communications are those set forth on the signature pages
hereof, or such other address or facsimile number as may be designated in writing hereafter, in the same manner, by any such Person.


 


Section 7.7.                     
Severability. If any portion of this Agreement shall be declared void or unenforceable by any court or administrative body
of competent jurisdiction, such portion shall be deemed severable from the remainder of this Agreement, which shall continue in
all respects valid and enforceable.


 


Section 7.8.                     
Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be deemed an original, but
all of which together shall constitute a single instrument.


 


[The remainder of this
page intentionally left blank]


 



    26


     

    




IN WITNESS WHEREOF, each of the undersigned
has executed this Agreement or caused this Agreement to be executed on its behalf as of the date first written above.


 


 





	 	AMYRIS, INC.
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 	 	 
	 	Address for Notice: 
	 	 	 
	 	 	 
	 	 	 
	 	 	 



 


 


 


	 	Facsimile No.:
	 	Email Address: 
	 	Attn:
	 	 
	 	with a copy (which shall not constitute notice) to:
	 	 
	 	Fenwick & West LLP
	 	801 California Street
	 	Mountain View, CA 94110
	 	Attention: David Michaels




	 	Email Address:	 



 



 


 



    [Signature Page to Stockholder Agreement]


     

    




IN WITNESS WHEREOF, each of the undersigned
has executed this Agreement or caused this Agreement to be executed on its behalf as of the date first written above.


 


	 	Vivo
Capital Fund VIII, L.P. 
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 	 	 



 

	 	Vivo
Surplus Funds VIII, L.P.
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:
	 	 	 


	 	Address: 	 
	 	 	 
	 	 	 


 


 


	 	Facsimile No.:	 
	 	Email Address:	 


 





	 	with a copy to (which shall not constitute notice)
to:
	 	 
	 	Perkins Coie LLP
	 	3150 Porter Drive
	 	Palo Alto, CA 94303
	 	Attention: Edward Wes



	 	Email Address:	 


 


 




 


 






    [Signature Page to Stockholder Agreement]


     

    
     

Exhibit D


 


PURCHASER SUITABILITY QUESTIONNAIRE 


FOR 


AMYRIS, INC.


 


This Questionnaire is to be completed by
each ENTITY (trust, corporation, partnership or other organization) purchasing securities of Amyris, Inc., a Delaware
corporation (the “Company”). The purpose of this Questionnaire is to assure the Company that the proposed
investor will meet certain suitability standards in connection with investment in the Company and the purchase of shares of (i)
the Company’s common stock, $0.0001 par value per share, and (ii) the Company’s Series D Convertible Preferred Stock,
$0.0001 par value per share (collectively, the “Shares”), including those imposed by applicable state
and federal securities laws and the regulations under those laws.


If the answer to any
question is “None” or ”Not Applicable,” please so state. If more space is needed for any answer, additional
sheets may be attached.


Your answers will be
kept confidential at all times. However, by signing this Questionnaire, you agree that the Company may present this Questionnaire
to such parties as it deems appropriate to establish the availability of exemptions from registration or qualification requirements
under federal and state securities laws.


1. IDENTIFICATION


 


 





	1.1	Name(s)
in which the Shares are to be registered:
	 	 
	 	 
	 	 
	1.2	Tax
Identification Number:
	 	 
	 	 
	1.3	Address
of principal place of business:
	 	 
	 	 
	 	 
	1.4	Telephone
number:______________________________________________________________
	 	 
	1.5	Jurisdiction
of formation or of incorporation (Name the State or Country):
	 	 
	 	 
	1.6	Form
of entity (e.g., corporation, general partnership, limited partnership, trust, etc.):
	 	 







 













 



 




     


     

    





	1.7	Nature of business
(e.g., investment, banking, manufacturing, venture capital investment fund, etc.):
	 	 
	 	 



 






 



2. ACCREDITATION


 





	2.1	Amount of the proposed investment: $ _________________________
	 	 	 
	2.2	Is the entity's cash flow from all sources sufficient to satisfy its current needs, including possible contingencies, such that the entity has no need for liquidity in this proposed investment?
	 	 
	 	 	Yes_____                  No_____
	 	 	 
	2.3	Was the entity specifically formed for the purpose of investing in the Company?
	 	 
	 	 	Yes_____                  No_____
	 	 	 
	2.4	Does the entity have the ability to bear the economic risk of the investment, i.e., can the entity afford to lose its entire investment?
	 	 
	 	 	Yes_____                  No_____
	 	 	 
	2.5	Is the entity an employee benefit plan governed by the Employee Retirement Income Security Act of 1974 (a 401(k) Plan, Keogh Plan, pension plan, etc., maintained by an employer for its employees)?
	 	 
	 	 	Yes_____                  No_____
	 	 	 
	 	IF YES, please indicate which, if any, of the following categories accurately describes the entity:
	 	 	 
	 	_____	the
employee benefit plan has total assets in excess of $5,000,000.
	 	 	 
	 	_____	the plan is a self-directed plan with investment decisions made solely by persons listed in Section
2.6 below or who are individuals, and each such individual has a net worth in excess $1,000,000 or had an individual income in
excess of $200,000 in each of the two most recent years and has a reasonable expectation of reaching the same income level in the
current year.
	 	 	 
	 	_____	investment decisions are made by a plan fiduciary which is either a bank, savings and loan association,
insurance company or registered investment advisor.
	 	 	 
	2.6	Please indicate which, if any, of the following categories accurately describes the entity:
	 	 	 
	 	_____	A
bank.
	 	 	 
	 	_____	A
savings and loan association.
	 	 	 



 





     


     

    

		_____	A broker-dealer registered under Section 15 of the Securities Exchange Act of 1934.
	 	 	 
	 	_____	An
insurance company.



 


		_____	An investment company registered under the Investment Company Act of 1940 or a business development
company as defined in Section 2(a)(48) of that Act.
	 	 	 



		_____	A Small Business Investment Company licensed by the U.S. Small Business Administration under Section
301(c) or (d) of the Small Business Investment Act of 1958.
	 	 	 



		_____	A private business development company defined in Section 202(a)(22) of the Investment Advisors
Act of 1940.
	 	 	 



		_____	An organization described in Section 501(c)(3) of the Internal Revenue Code with total assets in
excess of $5,000,000 not formed for the purpose of investing in the Company.
	 	 	 



		_____	A corporation with total assets in excess of $5,000,000, not formed for the purpose of investing
in the Company.
	 	 	 



		_____	A partnership with total assets in excess of $5,000,000, not formed for the purpose of investing
in the Company.
	 	 	 



		_____	A Massachusetts or similar business trust with total assets in excess of $5,000,000, not formed
for the purpose of investing in the Company.
	 	 	 



		_____	Any other trust with total assets in excess of $5,000,000, not formed for the purpose of investing
in the Company.
	 	 	 
	2.7	Please indicate if one of the following describes the equity owners of the entity:






 


		_____	Each equity owner of the entity (i.e., all shareholders, all general and/or limited partners or
all beneficiaries, as applicable) is an individual whose net worth or joint net worth with his or her spouse exceeds $1,000,000.
	 	 	 



		_____	Each equity owner of the entity is an individual who had a personal income in excess of $200,000
in each of the two (2) most recent years or joint income with that person's spouse in excess of $300,000 in each of those years
and reasonably expects to reach the same income level in the current year.
	 	 	 



		_____	Each equity owner of the entity is an entity described in at least one category of Question 2.6
above.
	 	 	 



		_____	Although not all equity owners are described in the same category above in this Question 2.7, each
equity owner is described in at least one such category.



     


     

    




	2.8	Please indicate which of the following also describes the equity owners of the entity:
	 	 
		_____	Each equity owner of the entity has, by reason of his, her or its business and financial experience,
the capacity to evaluate the merits and risks of the entity's proposed investment and to protect his, her or its own interests
in connection with the investment.
	 	 	 



		_____	Each of the equity owners of the entity is able to bear the economic risk of the entity's investment,
i.e., can afford loss of the entity's entire investment.
	 	 	 



		_____	The beneficial interest of each equity owner in the entity's proposed investment is less than 10%
of such equity owner's net worth, or joint net worth with his or her spouse.
	 	 	 



		_____	Although not all equity owners are described in the same category above in this Question 2.8, each
equity owner is described in at least one such category.



 


3. ADDITIONAL INFORMATION


 


		3.1	Has your entity previously invested in private placements of securities of newly-formed, non-public
companies or companies without a history of significant profits or earnings?



 


Never _______          Rarely
_______          On Several Occasions _______


 


		3.2	Does your entity, by reason of its business and financial knowledge and experience, have the capacity
to evaluate the merits and risks of the entity's proposed investment and to protect the entity's own interests in connection with
its investment in the Company?



 



	 	 	Yes_____                  No_____




 


	 	 	IF YES, please describe
the business and financial knowledge and experience, indicating factual basis for your conclusion that the entity has such capacity.
	 	 	 
	 	 	 
	 	 	 
	 	 	 






 





		3.3	Do the persons responsible for making the investment decision for the entity, by reason of their
business and financial knowledge and experience, have the capacity to evaluate the merits and risks of the entity's proposed investment?



 



	 	 	Yes_____                  No_____



 





	 	 	IF YES, please describe
the business and financial knowledge and experience, indicating factual basis for your conclusion that those persons have such
capacity.
	 	 	 
	 	 	 



 



 


 




     


     

    




	 	 	 
	 	 	 



 

		3.4	If you have used the services of a securities broker or dealer or a finder in submitting subscription
documentation for the Shares, please identify the broker, dealer or finder:
	 	 	 
	 	 	 
	 	 	 



 

		3.5	Are you relying on the business or financial experience of an accountant, attorney or other professional
advisor in evaluating the merits and risks of this investment in order to protect your own interest?
	 	 	 




	 	 	Yes_____                  No_____



 

	 	 	IF YES,
please (a) have your advisor complete the Company's form of Advisor's Questionnaire and submit it with this Questionnaire, and
(b) identify the advisor.
	 	 	 
	 	 	Name
of professional advisor:________________________________________________








 


4. EXECUTION


 


The information provided
in this Questionnaire is true and complete as of the date provided below in all material respects and the undersigned recognizes
that the Company is relying on the truth and accuracy of such information. The undersigned agrees to notify the Company promptly
of any changes in the foregoing information that may occur prior to the closing of the sale of Shares of the Company.


 


 





	 	Name of Entity:
	 	 	 
	 	 
	 	(Please Print or Type)
	 	 	 
	 	By:	 
	 	 	(Signature)
	 	 	 
	 	Name:	 
	 	 	(Please Print or Type)
	 	 	 
	 	Title:	 
	 	 	(Please Print or Type)
	 	 	 
	 	Date:	 
	 	 	 



 





 






     


     

    

Exhibit E


 


FORM OF CERTIFICATE OF DESIGNATION


 


 


 


 


 


 






     


     

    

AMYRIS,
INC.


 


CERTIFICATE OF DESIGNATION OF PREFERENCES,



RIGHTS AND LIMITATIONS


OF


SERIES D
CONVERTIBLE PREFERRED STOCK


 


PURSUANT
TO SECTION 151 OF THE 


DELAWARE
GENERAL CORPORATION LAW


 


The undersigned, John
Melo and Stephen Dobson, do hereby certify that:


 


1. They are the President
and Assistant Secretary, respectively, of Amyris, Inc., a Delaware corporation (the “Corporation”).


 


2. The Corporation
is authorized to issue 5,000,000 shares of preferred stock, none of which have been issued.


 


3. The following resolutions
were duly adopted by the board of directors of the Corporation (the “Board of Directors”):


 


WHEREAS, the certificate
of incorporation of the Corporation provides for a class of its authorized stock known as preferred stock, consisting of 5,000,000
shares, $0.0001 par value per share, issuable from time to time in one or more series;


 


WHEREAS, the Board
of Directors is authorized to fix the dividend rights, dividend rate, voting rights, conversion rights, rights and terms of redemption
and liquidation preferences of any wholly unissued series of preferred stock and the number of shares constituting any series and
the designation thereof, of any of them; and


 


WHEREAS, it is the
desire of the Board of Directors, pursuant to its authority as aforesaid, to fix the rights, preferences, restrictions and other
matters relating to a series of preferred stock, which shall consist of up to 15,000 shares of the preferred stock which the Corporation
has the authority to issue, as follows:


 


NOW, THEREFORE, BE
IT RESOLVED, that the Board of Directors does hereby provide for the issuance of a series of preferred stock for cash or exchange
of other securities, rights or property and does hereby fix and determine the rights, preferences, restrictions and other matters
relating to such series of preferred stock as follows:


 






    1


     

    

TERMS OF PREFERRED STOCK


 


Section 1. Definitions.
For the purposes hereof, the following terms shall have the following meanings:


 


“Affiliate”
means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or is under common
control with a Person, as such terms are used in and construed under Rule 405 of the Securities Act.


 


“Alternate
Consideration” shall have the meaning set forth in Section 7(e).


 


“Beneficial
Ownership Limitation” shall have the meaning set forth in Section 6(d).


 


“Business
Day” means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States or
any day on which banking institutions in the State of New York are authorized or required by law or other governmental action to
close.


 


“Change
of Control Transaction” means the occurrence after the applicable Original Issue Date of any of (a) an acquisition by
an individual or legal entity or “group” (as described in Rule 13d-5(b)(1) promulgated under the Exchange Act) of effective
control (whether through legal or beneficial ownership of capital stock of the Corporation, by contract or otherwise) of in excess
of 50% of the voting securities of the Corporation, (b) the Corporation merges into or consolidates with any other Person, or any
Person merges into or consolidates with the Corporation and, after giving effect to such transaction, the stockholders of the Corporation
immediately prior to such transaction own less than 50% of the aggregate voting power of the Corporation or the successor entity
of such transaction, (c) the Corporation sells or transfers all or substantially all of its assets to another Person and the stockholders
of the Corporation immediately prior to such transaction own less than 50% of the aggregate voting power of the acquiring entity
immediately after the transaction, (d) a replacement at one time or within a one year period of more than one-half of the members
of the Board of Directors which is not approved by a majority of those individuals who are members of the Board of Directors on
the applicable Original Issue Date (or by those individuals who are serving as members of the Board of Directors on any date whose
nomination to the Board of Directors was approved by a majority of the members of the Board of Directors who are members on the
applicable Original Issue Date), or (e) the execution by the Corporation of an agreement to which the Corporation is a party or
by which it is bound, providing for any of the events set forth in clauses (a) through (d) above.


 


“Closing”
means the closing of the purchase and sale of the Securities pursuant to Section 2.1 of the Purchase Agreement.


 


“Commission”
means the United States Securities and Exchange Commission.



    2


     

    




“Common
Shares” means the shares of Common Stock issued and sold by the Company pursuant to the Purchase Agreement.


 


“Common
Stock” means the Corporation’s common stock, par value $0.0001 per share, and any other class of securities into
which such securities may hereafter be reclassified or changed.


 


“Common
Stock Equivalents” means any securities of the Corporation or the Subsidiaries which would entitle the holder thereof
to acquire at any time Common Stock, including, without limitation, any debt, preferred stock, rights, options, warrants or other
instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to
receive, Common Stock.


 


“Conversion
Amount” means the Stated Value at issue.


 


“Conversion
Date” shall have the meaning set forth in Section 6(a).


 


“Conversion
Price” shall have the meaning set forth in Section 6(b).


 


“Conversion
Shares” means, collectively, the shares of Common Stock issuable upon conversion of the shares of Preferred Stock in
accordance with the terms hereof.


 


“Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.


 


“Fundamental
Transaction” shall have the meaning set forth in Section 7(e).


 


“Holder”
shall have the meaning given such term in Section 2.


 


“Liquidation”
shall have the meaning set forth in Section 5.


 


“New
York Courts” shall have the meaning set forth in Section 8(d).


 


“Notice
of Conversion” shall have the meaning set forth in Section 6(a).


 


“Original
Issue Date” means, with respect to a share of Preferred Stock, the date of the first issuance of any such share of Preferred
Stock regardless of the number of transfers of any such share of Preferred Stock and regardless of the number of certificates which
may be issued to evidence such Preferred Stock.


 


“Person”
means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.


 


“Preferred
Stock” shall have the meaning set forth in Section 2.


 



    3


     

    




“Purchase
Agreement” means the Securities Purchase Agreement, dated as of August 2, 2017, among the Corporation and the Holder,
as amended, modified or supplemented from time to time in accordance with its terms.


 


“Securities”
means the Common Shares, Preferred Stock, the Warrants, and the Underlying Shares.


 


“Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.


 


“Share
Delivery Date” shall have the meaning set forth in Section 6(c).


 


“Stated
Value” shall have the meaning set forth in Section 2, as the same may be increased pursuant to Section 3.


 


“Subsidiary”
means any subsidiary of the Corporation as disclosed in the Corporation’s Annual Report on Form 10-K for the year ended December 31,
2016 and shall, where applicable, also include any direct or indirect subsidiary of the Corporation formed or acquired after December
31, 2016.


 


“Successor
Entity” shall have the meaning set forth in Section 7(e).


 


“Trading
Day” means a day on which the principal Trading Market is open for business.


 


“Trading
Market” means any of the following markets or exchanges on which the Common Stock is listed or quoted for trading on
the date in question: the NYSE MKT, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New
York Stock Exchange, OTCQB or OTCQX (or any successors to any of the foregoing).


 


“Transfer
Agent” means Wells Fargo Shareholder Services, the current transfer agent of the Corporation with a mailing address of
1110 Centre Point Curve, Suite 101, Mendota Heights, MN 55120 and a telephone number of (855) 217-6361, and any successor transfer
agent of the Corporation.


 


“Underlying
Shares” means the shares of Common Stock issued and issuable (a) upon conversion of the Preferred Stock in accordance
with the terms of this Certificate of Designation and (b) upon exercise of the Warrants.


 


“VWAP”
means, for any date, the price determined by the first of the following clauses that applies: (a) if the Common Stock is then listed
or quoted on a Trading Market, the daily volume weighted average price of the Common Stock for such date (or the nearest preceding
date) on the Trading Market on which the Common Stock is then listed or quoted as reported by Bloomberg L.P. (based on a Trading
Day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time)), (b)  if OTCQB or OTCQX is not a Trading Market,
the volume weighted average price of the Common Stock for such date (or the nearest preceding date) on OTCQB or OTCQX as applicable,
(c) if the Common Stock is not then listed or quoted for trading on OTCQB or OTCQX and if prices for the Common Stock are then
reported in the “Pink Sheets” published by OTC Markets, Inc. (or a similar organization or agency succeeding to its
functions of reporting prices), the most recent bid price per share of the Common Stock so reported, or (d) in all other cases,
the fair market value of a share of Common Stock as determined by an independent appraiser selected in good faith by the Holders
of a majority in interest of the Preferred Stock then outstanding and reasonably acceptable to the Corporation, the fees and expenses
of which shall be paid by the Corporation.


 



    4


     

    




“Warrants”
means, collectively, the Common Stock purchase warrants delivered to the Holder at the Closing in accordance with Section 6(g)
of the Purchase Agreement, in the forms of Exhibit A and Exhibit B attached to the Purchase Agreement.


 


Section
2. Designation, Amount and Par Value. The series of preferred stock shall be designated as its Series D Convertible
Preferred Stock (the “Preferred Stock”) and the number of shares so designated shall be up to 15,000 (which
may be increased without the written consent of all of the holders of the Preferred Stock (each, a “Holder”
and collectively, the “Holders”)). Each share of Preferred Stock shall have a par value of $0.0001 per share
and a stated value equal to $1,000 (the “Stated Value”).


 


Section 3. Dividends.
Prior to declaring any dividend or other distribution of its assets (or right to acquire its assets) to holders of shares of Common
Stock, by way of return of capital or otherwise (including, without limitation, any distribution of cash, stock or other securities,
property or options by way of a dividend, spin off, reclassification, corporate rearrangement, scheme of arrangement or other similar
transaction, but excluding any dividend that results in adjustment to the Conversion Price pursuant to Section 7(a) below) (a “Distribution”),
the Corporation shall first declare a dividend per share on the Preferred Stock equal to $0.0001 per share. Subject to the preceding
sentence, if the Corporation declares or makes any other Distribution to the holders of shares of Common Stock, then Holders shall
be entitled to receive, and the Corporation shall make payments on shares of Preferred Stock equal (on an as-if-converted-to-Common-Stock
basis, disregarding for such purpose any conversion limitations hereunder) to and in the same form as such Distribution is actually
paid on shares of the Common Stock when, as and if such dividends are paid on shares of the Common Stock. Except as set forth in
the first sentence of this Section 3, no other Distributions shall be paid on shares of Preferred Stock. The Corporation shall
not pay any dividends on the Common Stock unless the Corporation simultaneously complies with this provision.


 


Section 4. Voting
Rights. Except as otherwise provided herein or as otherwise required by law, the Preferred Stock shall have no voting rights.
However, as long as any shares of Preferred Stock are outstanding, the Corporation shall not, without the affirmative vote of the
Holders of a majority of the then outstanding shares of the Preferred Stock, (a) alter or change adversely the powers, preferences
or rights given to the Preferred Stock, (b) authorize or create any class of stock ranking as to dividends, redemption or distribution
of assets upon a Liquidation (as defined in Section 5) senior to, or otherwise pari passu with, the Preferred Stock, (c)
amend its certificate of incorporation or other charter documents, including this Certificate of Designation, in any manner that
adversely affects any rights of the Holders, (d) increase the number of authorized shares of Preferred Stock, or (e) enter into
any agreement with respect to any of the foregoing.


 



    5


     

    




Section 5. Liquidation.
Upon any liquidation, dissolution or winding-up of the Corporation, whether voluntary or involuntary (a “Liquidation”),
the Holders shall be entitled to receive out of the assets, whether capital or surplus, of the Corporation the same amount and
form of consideration that a holder of Common Stock would receive if the Preferred Stock were fully converted (disregarding for
such purposes any conversion limitations hereunder) to Common Stock which amounts shall be paid pari passu with all holders of
Common Stock. A Fundamental Transaction or Change of Control Transaction shall be deemed a Liquidation; provided, that a Change
of Control Transaction where the Corporation is the surviving corporation and the Common Stock remains listed or quoted on any
trading market, shall not be deemed a Liquidation. The Corporation shall mail written notice of any such Liquidation, not less
than 20 days prior to the payment date stated therein, to each Holder.


 


Section 6. Conversion.


 


a)                 
Conversions at Option of Holder. Each share of Preferred Stock shall be convertible, at any time and from time to
time from and after the applicable Original Issue Date at the option of the Holder thereof, into that number of shares of Common
Stock (subject to the limitation set forth in Section 6(d)) determined by dividing the Stated Value of such share of Preferred
Stock by the Conversion Price. Holders shall effect conversions by providing the Corporation with the form of conversion notice
attached hereto as Annex A (a “Notice of Conversion”). Each Notice of Conversion shall specify the number
of shares of Preferred Stock to be converted, the number of shares of Preferred Stock owned prior to the conversion at issue, the
number of shares of Preferred Stock owned subsequent to the conversion at issue and the date on which such conversion is to be
effected, which date may not be prior to the date the applicable Holder delivers by facsimile or email such Notice of Conversion
to the Corporation (such date, the “Optional Conversion Date”). If no Optional Conversion Date is specified
in a Notice of Conversion, the Optional Conversion Date shall be the date that such Notice of Conversion to the Corporation is
deemed delivered hereunder. No ink-original Notice of Conversion shall be required, nor shall any medallion guarantee (or other
type of guarantee or notarization) of any Notice of Conversion form be required. The calculations and entries set forth in the
Notice of Conversion shall control in the absence of manifest or mathematical error. To effect conversions of shares of Preferred
Stock, a Holder shall not be required to surrender the certificate(s) representing the shares of Preferred Stock to the Corporation
unless all of the shares of Preferred Stock represented thereby are so converted, in which case such Holder shall deliver the certificate
representing such shares of Preferred Stock promptly following the Conversion Date at issue. Shares of Preferred Stock converted
into Common Stock or redeemed in accordance with the terms hereof shall be canceled and shall not be reissued.


 



    6


     

    




b)                 
Conversion Price. The conversion price for the Preferred Stock shall equal $4.26, subject to adjustment as set forth
herein (the “Conversion Price”).


 


 c)                 
Mechanics of Conversion




 


i.                       
Delivery of Conversion Shares Upon Conversion. Not later than three (3) Trading Days and after each Conversion Date
(the “Share Delivery Date”), the Corporation shall deliver, or cause to be delivered, to the converting Holder
the number of Conversion Shares being acquired upon the conversion of the Preferred Stock.


 


ii.                       
Failure to Deliver Conversion Shares. If, in the case of any Notice of Conversion, such Conversion Shares are not
delivered to or as directed by the applicable Holder by the Share Delivery Date, the Holder shall be entitled to elect by written
notice to the Corporation at any time on or before its receipt of such Conversion Shares, to rescind such Conversion, in which
event the Corporation shall promptly return to the Holder any original Preferred Stock certificate delivered to the Corporation
and the Holder shall promptly return to the Corporation the Conversion Shares issued to such Holder pursuant to the rescinded Notice
of Conversion.


 


iii.                       
Obligation Absolute. The Corporation’s obligation to issue and deliver the Conversion Shares upon conversion
of Preferred Stock in accordance with the terms hereof are absolute and unconditional, irrespective of any action or inaction by
a Holder to enforce the same, any waiver or consent with respect to any provision hereof, the recovery of any judgment against
any Person or any action to enforce the same, or any setoff, counterclaim, recoupment, limitation or termination, or any breach
or alleged breach by such Holder or any other Person of any obligation to the Corporation or any violation or alleged violation
of law by such Holder or any other person, and irrespective of any other circumstance which might otherwise limit such obligation
of the Corporation to such Holder in connection with the issuance of such Conversion Shares; provided, however, that
such delivery shall not operate as a waiver by the Corporation of any such action that the Corporation may have against such Holder.
In the event a Holder shall elect to convert any or all of the Stated Value of its Preferred Stock or in connection with any mandatory
conversion pursuant to Section 6(a)(ii), the Corporation may not refuse conversion based on any claim that such Holder or any one
associated or affiliated with such Holder has been engaged in any violation of law, agreement or for any other reason, unless an
injunction from a court, on notice to Holder, restraining and/or enjoining conversion of all or part of the Preferred Stock of
such Holder shall have been sought and obtained, and the Corporation posts a surety bond for the benefit of such Holder in the
amount of 150% of the Stated Value of Preferred Stock which is subject to the injunction, which bond shall remain in effect until
the completion of arbitration/litigation of the underlying dispute and the proceeds of which shall be payable to such Holder to
the extent it obtains judgment. In the absence of such injunction, the Corporation shall issue Conversion Shares upon a properly
noticed conversion.


 



    7


     

    




iv.                       
Reservation of Shares Issuable Upon Conversion. The Corporation covenants that it will at all times reserve and keep
available out of its authorized and unissued shares of Common Stock for the sole purpose of issuance upon conversion of the Preferred
Stock, as herein provided, free from preemptive rights or any other actual contingent purchase rights of Persons other than the
Holder (and the other holders of the Preferred Stock), not less than such aggregate number of shares of the Common Stock as shall
(subject to the terms and conditions set forth in the Purchase Agreement) be issuable (taking into account the adjustments and
restrictions of Section 7) upon the conversion of the then outstanding shares of Preferred Stock. The Corporation covenants that
all shares of Common Stock that shall be so issuable shall, upon issue, be duly authorized, validly issued, fully paid and nonassessable.


 


v.                       
Fractional Shares. No fractional shares or scrip representing fractional shares shall be issued upon the conversion
of the Preferred Stock. As to any fraction of a share which the Holder would otherwise be entitled to purchase upon such conversion,
the Corporation shall at its election, either pay a cash adjustment in respect of such final fraction in an amount equal to such
fraction multiplied by the Conversion Price or round up to the next whole share.


 


vi.                       
Transfer Taxes and Expenses. The issuance of Conversion Shares on conversion of this Preferred Stock shall be made
without charge to any Holder for any documentary stamp or similar taxes that may be payable in respect of the issue or delivery
of such Conversion Shares, provided that the Corporation shall not be required to pay any tax that may be payable in respect of
any transfer involved in the issuance and delivery of any such Conversion Shares upon conversion in a name other than that of the
Holders of such shares of Preferred Stock and the Corporation shall not be required to issue or deliver such Conversion Shares
unless or until the Person or Persons requesting the issuance thereof shall have paid to the Corporation the amount of such tax
or shall have established to the reasonable satisfaction of the Corporation that such tax has been paid. The Corporation shall
pay all Transfer Agent fees required for same-day processing of any Notice of Conversion and all fees to the Depository Trust Company
(or another established clearing corporation performing similar functions) required for same-day electronic delivery of the Conversion
Shares.


 



    8


     

    




d)                
Beneficial Ownership Limitation. Notwithstanding anything to the contrary contained herein, the Corporation shall
not effect any conversion of the Preferred Stock, and a Holder shall not have the right to convert any portion of the Preferred
Stock, to the extent that, after giving effect to the conversion set forth on the applicable Notice of Conversion, such Holder
(together with such Holder’s Affiliates, and any Persons acting as a group together with such Holder or any of such Holder’s
Affiliates (such Persons, “Attribution Parties”)) would beneficially own in excess of the Beneficial Ownership
Limitation (as defined below).  For purposes of the foregoing sentence, the number of shares of Common Stock beneficially
owned by such Holder and its Affiliates and Attribution Parties shall include the number of shares of Common Stock issuable upon
conversion of the Preferred Stock with respect to which such determination is being made, but shall exclude the number of shares
of Common Stock which are issuable upon (i) conversion of the remaining, unconverted Stated Value of Preferred Stock beneficially
owned by such Holder or any of its Affiliates or Attribution Parties and (ii) exercise or conversion of the unexercised or unconverted
portion of any other securities of the Corporation subject to a limitation on conversion or exercise analogous to the limitation
contained herein (including, without limitation, the Preferred Stock or the Warrants) beneficially owned by such Holder or any
of its Affiliates or Attribution Parties.  Except as set forth in the preceding sentence, for purposes of this Section 6(d),
beneficial ownership shall be calculated in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated
thereunder. To the extent that the limitation contained in this Section 6(d) applies, the determination of whether the Preferred
Stock is convertible (in relation to other securities owned by such Holder together with any Affiliates and Attribution Parties)
and of how many shares of Preferred Stock are convertible shall be in the sole discretion of such Holder (provided that such determination
by Holder shall be reasonably acceptable to the Corporation), and the submission of a Notice of Conversion shall be deemed to
be such Holder’s determination of whether the shares of Preferred Stock may be converted (in relation to other securities
owned by such Holder together with any Affiliates and Attribution Parties) and how many shares of the Preferred Stock are convertible,
in each case subject to the Beneficial Ownership Limitation. To ensure compliance with this restriction, each Holder will be deemed
to represent to the Corporation each time it delivers a Notice of Conversion that such Notice of Conversion has not violated the
restrictions set forth in this paragraph and the Corporation shall have no obligation to verify or confirm the accuracy of such
determination. In addition, a determination as to any group status as contemplated above shall be determined in accordance with
Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder. For purposes of this Section 6(d), in
determining the number of outstanding shares of Common Stock, a Holder may rely on the number of outstanding shares of Common
Stock as stated in the most recent of the following: (i) the Corporation’s most recent periodic or annual report filed with
the Commission, as the case may be, (ii) a more recent public announcement by the Corporation or (iii) a more recent written notice
by the Corporation or the Transfer Agent setting forth the number of shares of Common Stock outstanding.  Upon the written
or oral request of a Holder, the Corporation shall within two Trading Days confirm orally and in writing to such Holder the number
of shares of Common Stock then outstanding.  In any case, the number of outstanding shares of Common Stock shall be determined
after giving effect to the conversion or exercise of securities of the Corporation, including the Preferred Stock, by such Holder
or its Affiliates or Attribution Parties since the date as of which such number of outstanding shares of Common Stock was reported.
The “Beneficial Ownership Limitation” shall be 9.99% of the number of shares of the Common Stock outstanding
immediately after giving effect to the issuance of shares of Common Stock issuable upon conversion of Preferred Stock held by
the applicable Holder. A Holder, upon notice to the Corporation, may waive the Beneficial Ownership Limitation provisions of this
Section 6(d) applicable to its Preferred Stock, provided that such waiver (i) will not be effective until the 61st
day after such notice is delivered to the Corporation, (ii) shall only apply to such Holder and no other Holder and (iii) will
not be effective to the extent such waiver would require the prior approval of the Corporation’s stockholders, unless such
approval has been obtained. If such stockholder approval is required and has not been obtained, the Corporation shall use its
commercially reasonable efforts to timely obtain such stockholder approval. The provisions of this paragraph shall be construed
and implemented in a manner otherwise than in strict conformity with the terms of this Section 6(d) to correct this paragraph
(or any portion hereof) which may be defective or inconsistent with the intended Beneficial Ownership Limitation contained herein
or to make changes or supplements necessary or desirable to properly give effect to such limitation. The limitations contained
in this paragraph shall apply to a successor holder of Preferred Stock.


 



    9


     

    




Section 7. Certain
Adjustments.


 


a)                 
Stock Dividends and Stock Splits. If the Corporation, at any time while this Preferred Stock is outstanding: (i)
pays a stock dividend or otherwise makes a distribution or distributions payable in shares of Common Stock on shares of Common
Stock or any other Common Stock Equivalents (which, for avoidance of doubt, shall not include any shares of Common Stock issued
by the Corporation upon conversion of, or payment of a dividend on, this Preferred Stock), (ii) subdivides outstanding shares of
Common Stock into a larger number of shares, (iii) combines (including by way of a reverse stock split) outstanding shares of Common
Stock into a smaller number of shares, or (iv) issues, in the event of a reclassification of shares of the Common Stock, any shares
of capital stock of the Corporation, then the Conversion Price shall be multiplied by a fraction of which the numerator shall be
the number of shares of Common Stock (excluding any treasury shares of the Corporation) outstanding immediately before such event,
and of which the denominator shall be the number of shares of Common Stock outstanding immediately after such event. Any adjustment
made pursuant to this Section 7(a) shall become effective immediately after the record date for the determination of stockholders
entitled to receive such dividend or distribution and shall become effective immediately after the effective date in the case of
a subdivision, combination or re-classification.


 


b)                 
Subsequent Rights Offerings. In addition to any adjustments pursuant to Section 7(a) above, if at any time subsequent
to the applicable Original Issue Date the Corporation grants, issues or sells any Common Stock Equivalents or rights to purchase
stock, warrants, securities or other property pro rata to the record holders of any class of shares of Common Stock, but excluding
any issuances under any control share acquisition, business combination, poison pill (including any distribution under a rights
agreement) or similar anti-takeover plan or arrangement in effect or hereafter adopted by the Corporation (the “Purchase
Rights”), then each Holder of Preferred Stock will be entitled to acquire, upon the terms applicable to such Purchase
Rights, the aggregate Purchase Rights which the Holder could have acquired if the Holder had held the number of shares of Common
Stock acquirable upon complete conversion of such Holder’s Preferred Stock (without regard to any limitations on exercise
hereof, including without limitation, the Beneficial Ownership Limitation) immediately before the date on which a record is taken
for the grant, issuance or sale of such Purchase Rights, or, if no such record is taken, the date as of which the record holders
of shares of Common Stock are to be determined for the grant, issue or sale of such Purchase Rights (provided, however, to the
extent that the right of a Holder to participate in any such Purchase Right would result in the Holder exceeding the Beneficial
Ownership Limitation and the Beneficial Ownership Limitation is not waived by the Holder, then the Holder shall not be entitled
to participate in such Purchase Right to such extent (or beneficial ownership of such shares of Common Stock as a result of such
Purchase Right to such extent) and such Purchase Right to such extent shall be held in abeyance for the Holder until such time,
if ever, as its right thereto would not result in the Holder exceeding the Beneficial Ownership Limitation).


 



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c)                 
Pro Rata Distributions. During such time as this Preferred Stock is outstanding, if the Corporation shall declare
or make any Distribution, at any time after the issuance of this Preferred Stock, then, in each such case, the Holder shall be
entitled to participate in such Distribution to the same extent that the Holder would have participated therein if the Holder had
held the number of shares of Common Stock acquirable upon complete conversion of this Preferred Stock (without regard to any limitations
on conversion hereof, including without limitation, the Beneficial Ownership Limitation) immediately before the date of which a
record is taken for such Distribution, or, if no such record is taken, the date as of which the record holders of shares of Common
Stock are to be determined for the participation in such Distribution (provided, however, to the extent that the
right of a Holder to participate in any such Distribution would result in the Holder exceeding the Beneficial Ownership Limitation
and the Beneficial Ownership Limitation is not waived by the Holder, then the Holder shall not be entitled to participate in such
Distribution to such extent (or in the beneficial ownership of any shares of Common Stock as a result of such Distribution to such
extent) and the portion of such Distribution shall be held in abeyance for the benefit of the Holder until such time, if ever,
as its right thereto would not result in the Holder exceeding the Beneficial Ownership Limitation).


 


d)                
Fundamental Transaction. If, at any time while this Preferred Stock is outstanding, (i) the Corporation, directly
or indirectly, in one or more related transactions effects any merger or consolidation of the Corporation with or into another
Person, (ii) the Corporation, directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other
disposition of all or substantially all of its assets in one or a series of related transactions, (iii) any, direct or indirect,
purchase offer, tender offer or exchange offer (whether by the Corporation or another Person) is completed pursuant to which holders
of Common Stock are permitted to sell, tender or exchange their shares for other securities, cash or property and has been accepted
by the holders of 50% or more of the outstanding Common Stock, (iv) the Corporation, directly or indirectly, in one or more related
transactions effects any reclassification, reorganization or recapitalization of the Common Stock or any compulsory share exchange
pursuant to which the Common Stock is effectively converted into or exchanged for other securities, cash or property, or (v) the
Corporation, directly or indirectly, in one or more related transactions consummates a stock or share purchase agreement or other
business combination (including, without limitation, a reorganization, recapitalization, spin-off or scheme of arrangement) with
another Person whereby such other Person acquires more than 50% of the outstanding shares of Common Stock (not including any shares
of Common Stock held by the other Person or other Persons making or party to, or associated or affiliated with the other Persons
making or party to, such stock or share purchase agreement or other business combination) (each a “Fundamental Transaction”),
then, the Holder shall have the right to receive, for each Conversion Share that would have been issuable upon such conversion
immediately prior to the occurrence of such Fundamental Transaction (had the Conversion Time occurred immediately prior to the
occurrence of such Fundamental Transaction and without regard to any limitation in Section 6(d) on the conversion of this Preferred
Stock), the number of shares of common stock of the successor or acquiring corporation or shares of Common Stock of the Corporation,
if it is the surviving corporation, and any additional consideration (the “Alternate Consideration”) receivable
as a result of such Fundamental Transaction by a holder of the number of shares of Common Stock for which this Preferred Stock
is convertible immediately prior to such Fundamental Transaction (without regard to any limitation in Section 6(d) on the conversion
of this Preferred Stock). For purposes of any such conversion, the determination of the Conversion Price shall be appropriately
adjusted to apply to such Alternate Consideration based on the amount of Alternate Consideration issuable in respect of one share
of Common Stock in such Fundamental Transaction, and the Corporation shall apportion the Conversion Price among the Alternate Consideration
in a reasonable manner reflecting the relative value of any different components of the Alternate Consideration. If holders of
Common Stock are given any choice as to the securities, cash or property to be received in a Fundamental Transaction, then the
Holder shall be given the same choice as to the Alternate Consideration it receives upon any conversion of this Preferred Stock
following such Fundamental Transaction.


 



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e)                 
Calculations. All calculations under this Section 7 shall be made to the nearest cent or the nearest 1/100th of a
share, as the case may be. For purposes of this Section 7, the number of shares of Common Stock deemed to be issued and outstanding
as of a given date shall be the sum of the number of shares of Common Stock (excluding any treasury shares of the Corporation)
issued and outstanding.


 


f)                  
Notice to the Holders.


 


i.                       
Adjustment to Conversion Price. Whenever the Conversion Price is adjusted pursuant to any provision of this Section
7, the Corporation shall promptly deliver to each Holder by facsimile or email a notice setting forth the Conversion Price after
such adjustment and setting forth a brief statement of the facts requiring such adjustment.


 



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ii.                       
Notice to Allow Conversion by Holder. If (A) the Corporation shall declare a dividend (or any other distribution
in whatever form) on the Common Stock, (B) the Corporation shall declare a special nonrecurring cash dividend on or a redemption
of the Common Stock, (C) the Corporation shall authorize the granting to all holders of the Common Stock of rights or warrants
to subscribe for or purchase any shares of capital stock of any class or of any rights, (D) the approval of any stockholders of
the Corporation shall be required in connection with any reclassification of the Common Stock, any consolidation or merger to which
the Corporation is a party, any sale or transfer of all or substantially all of the assets of the Corporation, or any compulsory
share exchange whereby the Common Stock is converted into other securities, cash or property or (E) the Corporation shall authorize
the voluntary or involuntary dissolution, liquidation or winding up of the affairs of the Corporation, then, in each case, the
Corporation shall cause to be filed at each office or agency maintained for the purpose of conversion of this Preferred Stock,
and shall cause to be delivered by facsimile or email to each Holder at its last facsimile number or email address as it shall
appear upon the stock books of the Corporation, at least twenty (20) calendar days prior to the applicable record or effective
date hereinafter specified, a notice stating (x) the date on which a record is to be taken for the purpose of such dividend, distribution,
redemption, rights or warrants, or if a record is not to be taken, the date as of which the holders of the Common Stock of record
to be entitled to such dividend, distributions, redemption, rights or warrants are to be determined or (y) the date on which such
reclassification, consolidation, merger, sale, transfer or share exchange is expected to become effective or close, and the date
as of which it is expected that holders of the Common Stock of record shall be entitled to exchange their shares of the Common
Stock for securities, cash or other property deliverable upon such reclassification, consolidation, merger, sale, transfer or share
exchange, provided that the failure to deliver such notice or any defect therein or in the delivery thereof shall not affect the
validity of the corporate action required to be specified in such notice. To the extent that any notice provided hereunder constitutes,
or contains, material, non-public information regarding the Corporation or any of the Subsidiaries, the Corporation shall simultaneously
file such notice with the Commission pursuant to a Current Report on Form 8-K. The Holder shall remain entitled to convert the
Conversion Amount of this Preferred Stock (or any part hereof) during the 20-day period commencing on the date of such notice through
the effective date of the event triggering such notice except as may otherwise be expressly set forth herein.


 


Section 8. Miscellaneous.


 


a)                 
Notices. Any and all notices or other communications or deliveries to be provided by the Holders hereunder including,
without limitation, any Notice of Conversion, shall be in writing and delivered personally, by facsimile or e-mail, or sent by
a nationally recognized overnight courier service, addressed to the Corporation, at the address set forth above Attention: General
Counsel, facsimile number (510) 225-2645, e-mail address GeneralCounsel@amyris.com, or such other facsimile number, e-mail address
or address as the Corporation may specify for such purposes by notice to the Holders delivered in accordance with this Section
8. Any and all notices or other communications or deliveries to be provided by the Corporation hereunder shall be in writing and
delivered personally, by facsimile or e-mail, or sent by a nationally recognized overnight courier service addressed to each Holder
at the facsimile number, e-mail address or address of such Holder appearing on the books of the Corporation, or if no such facsimile
number, e-mail address or address appears on the books of the Corporation, at the principal place of business of such Holder. Any
notice or other communication or deliveries hereunder shall be deemed given and effective on the earliest of (i) the date of transmission,
if such notice or communication is delivered via facsimile at the facsimile number or e-mail at the e-mail address set forth in
this Section prior to 5:30 p.m. (New York City time) on any date, (ii) the next Trading Day after the date of transmission, if
such notice or communication is delivered via facsimile at the facsimile number or e-mail at the e-mail address set forth in this
Section on a day that is not a Trading Day or later than 5:30 p.m. (New York City time) on any Trading Day, (iii) the second Trading
Day following the date of mailing, if sent by U.S. nationally recognized overnight courier service, or (iv) upon actual receipt
by the party to whom such notice is required to be given.


 



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b)                 
Absolute Obligation. Except as expressly provided herein, no provision of this Certificate of Designation shall alter
or impair the obligation of the Corporation, which is absolute and unconditional, to pay late fees, liquidated damages, accrued
dividends and accrued interest, as applicable, on the shares of Preferred Stock at the time, place, and rate, and in the coin or
currency, herein prescribed.


 


c)                 
Lost or Mutilated Preferred Stock Certificate. If a Holder’s Preferred Stock certificate shall be mutilated,
lost, stolen or destroyed, the Corporation shall execute and deliver, in exchange and substitution for and upon cancellation of
a mutilated certificate, or in lieu of or in substitution for a lost, stolen or destroyed certificate, a new certificate for the
shares of Preferred Stock so mutilated, lost, stolen or destroyed, but only upon receipt of evidence of such loss, theft or destruction
of such certificate, and of the ownership hereof reasonably satisfactory to the Corporation.


 


d)                
Governing Law. All questions concerning the construction, validity, enforcement and interpretation of this Certificate
of Designation shall be governed by and construed and enforced in accordance with the internal laws of the State of Delaware, without
regard to the principles of conflict of laws thereof. Each party agrees that all legal proceedings concerning the interpretation,
enforcement and defense of the transactions contemplated this Certificate of Designation (whether brought against a party hereto
or its respective Affiliates, directors, officers, shareholders, employees or agents) shall be commenced in the state and federal
courts sitting in the City of New York, Borough of Manhattan (the “New York Courts”). Each party hereto hereby
irrevocably submits to the exclusive jurisdiction of the New York Courts for the adjudication of any dispute hereunder or in connection
herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert
in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of such New York Courts, or
such New York Courts are improper or inconvenient venue for such proceeding. Each party hereby irrevocably waives personal service
of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof via registered
or certified mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices to it under
this Certificate of Designation and agrees that such service shall constitute good and sufficient service of process and notice
thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any other manner permitted
by applicable law. Each party hereto hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all
right to trial by jury in any legal proceeding arising out of or relating to this Certificate of Designation or the transactions
contemplated hereby. If any party shall commence an action or proceeding to enforce any provisions of this Certificate of Designation,
then the prevailing party in such action or proceeding shall be reimbursed by the other party for its attorneys’ fees and
other costs and expenses incurred in the investigation, preparation and prosecution of such action or proceeding.


 



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e)                 
Severability. If any provision of this Certificate of Designation is invalid, illegal or unenforceable, the balance
of this Certificate of Designation shall remain in effect, and if any provision is inapplicable to any Person or circumstance,
it shall nevertheless remain applicable to all other Persons and circumstances. If it shall be found that any interest or other
amount deemed interest due hereunder violates the applicable law governing usury, the applicable rate of interest due hereunder
shall automatically be lowered to equal the maximum rate of interest permitted under applicable law.


 


f)                  
Next Business Day. Whenever any payment or other obligation hereunder shall be due on a day other than a Business
Day, such payment shall be made on the next succeeding Business Day.


 


g)                 
Headings. The headings contained herein are for convenience only, do not constitute a part of this Certificate of
Designation and shall not be deemed to limit or affect any of the provisions hereof.


 


h)                 
Status of Converted or Redeemed Preferred Stock. If any shares of Preferred Stock shall be converted, redeemed or
reacquired by the Corporation, such shares shall resume the status of authorized but unissued shares of preferred stock and shall
no longer be designated as Series D Convertible Preferred Stock.


 


 


*********************



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RESOLVED, FURTHER, that the Chairman, the
president or any vice-president, and the secretary or any assistant secretary, of the Corporation be and they hereby are authorized
and directed to prepare and file this Certificate of Designation of Preferences, Rights and Limitations in accordance with the
foregoing resolution and the provisions of Delaware law.


 


IN WITNESS WHEREOF,
the undersigned have executed this Certificate this ___ day of August 2017.


 





	 	 	 
	Name: John Melo	 	Name: Stephen Dobson
	Title: President and CEO	 	Title: Assistant Secretary
	 	 	 
	 	 	 



 


 


 


 


 


 


 


 






    	 	16	 



     

    

 





ANNEX A


 


NOTICE OF CONVERSION


 


(To
be Executed by the Registered Holder in order to Convert Shares of Preferred Stock)


 


The undersigned hereby elects to convert
the number of shares of Series D Convertible Preferred Stock indicated below into shares of common stock, par value $0.0001 per
share (the “Common Stock”), of Amyris, Inc., a Delaware corporation (the “Corporation”),
according to the conditions hereof, as of the date written below. If shares of Common Stock are to be issued in the name of a Person
other than the undersigned, the undersigned will pay all transfer taxes payable with respect thereto and is delivering herewith
such certificates and opinions as may be required by the Corporation in accordance with the Purchase Agreement. No fee will be
charged to the Holders for any conversion, except for any such transfer taxes.


 


Conversion calculations:


 


 





	Date to Effect Conversion: 	 	 



 


	Number of shares of Preferred Stock owned
        prior to Conversion:	 	 



 





	Number of shares of Preferred Stock to
        be Converted:	 	 



 





	Stated Value of shares of Preferred Stock
        to be Converted:	 	 



 





	Number of shares of Common Stock to be
        Issued:	 	 



 





	Applicable Conversion Price:	 	 



 





	Number of shares of Preferred Stock subsequent
        to Conversion:	 	 



 


Address for Delivery: _________________________________


or


DWAC Instructions:


Broker no: _________


Account no: ___________


   



 


 





	 	[HOLDER]	 
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:



 


 


 


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