~P~ ZcX~~=05.3/ Lonza 

CERTIFIED MAIL - RETURN RECEIPT REQUESTED 

Document Control Office (7407M) 

Office of Pollution Prevention and Toxics (OPPT) 

Environmental Protection Agency 

1200 Pennsylvania Ave., N.W. 

Washington, DC 20460-0001 

Lonza Inc. 

90 Boroline Road 

Allendale, NJ 07401, USA 

p. 1 

rY1kO.3337/11 

Robert J . Sloan 

Senior Manager ~" ` 1 710 

Regulatory Compliance - Americas i"T? 

n 

Phone: (201) 316-9365 

Fax: (201) 696-3569 '0 

bob.sloan@lonza .com 

March 7, 2011 

0 

Attn : TSCA Section 4 

40 CFR Part 799 .5087 

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In compliance with the final rule, "Testing of Certain High Production Volume Chemicals; Second Group of 

Chemicals", 76FR1067, January 17, 2011, Lonza Inc . submits this Letter of Intent to test for "1 H,3HBenzo[1,2-c :4,5-c']difuran-1,3,5,7-tetrone", CAS number 89-32-7 . Lonza Inc . intends to either obtain EPA 

approval to waive the requirements and/or conduct the required testing and/or submit existing data to meet all 

the required endpoints as outlined in the final rule . The company plans to conduct the testing, submit existing data or submit information supporting a waiver of 

the requirement for the following endpoints. 

A3 : Vapor Pressure 

A4 : n-Octanol/Water Partition Coefficient (log 10 basis) or log KOW 

A5 : Water Solubility 

B: Inherant Biodegradation 

C1 : Aquatic Toxicity 

D: Mammalian Toxicity -- Acute 

E1 : Mammalian Toxicity -- Genotoxicity 

F1 : Mammalian toxicity -- repeated dose/ reproduction/ developmental 

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The company believes that sufficient data exists to meet the following endpoint . The company will submit this 

data along with, if necessary, a request to modify the testing requirements to match the conditions under which 

the data was developed. 

E1 : Mammalian Toxicity -- Genotoxicity 

The following relevant data is available from literature (HSDB-, RTECS-Databases etc .) or QSAR estimation. The 

company will submit this data or references to this data along with requests to modify the testing requirements for 

the following endpoints: 

A3 : Vapor pressure (EPI-suite estimation / EPA 2003) 

A4 : Partition coefficient log (EPI-suite estimation / EPA 2003) 

A5 : Water solubility (EPI-suite estimation / EPA 2003) 

D : Acute oral toxicity (Lit : various) ~a4 NU~Nwpui~0 pi~iux3 puAu 

The company will conduct the following testing to meet the following endpoints: 

B: Inherant Biodegradation 

CONTAINS NO C! 
p. 2 

The company will conduct the following testing to meet the following endpoints or provide adequate 

justification to support EPA approval of a waiver : 

F1 : Mammalian toxicity -- repeated dose/ reproduction/ developmental 

The company will conduct the following testing to determine if other testing requirements might be waived . 

The company will submit a formal Test Plan upon completion of this study: 

Abiotic degradation : Hydrolysis as a function of pH - OECD 111 

If the hydrolysis 1/2 life is very short, the company will request a waiver for the following testing requirement. If the 

hydrolysis rate is not short, the company will conduct the following testing to meet the following endpoint: 

C1 : Aquatic Toxicity 

The contact information for the corporation and contact person filing this letter of intent to test and the primary 

contact for this testing is provided below. 

Robert Sloan 

Lonza Inc. 

90 Boroline Road 

Allendale, NJ 07401 USA 

Telephone 201-316-9365 

Fax 201-696-3569 

Email : bob. sloanCc~lonza .com 

If you have any questions, please contact me and at the number provided above . 

Sincerely, 

4t -- 

Robert J. o 

Senior nager, Regulatory Compliance - Americas