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# Lonza

CERTIFIED MAIL - RETURN RECEIPT REQUESTED Document Control Office (7407M) Office of Pollution Prevention and Toxics (OPPT) Environmental Protection Agency 1200 Pennsylvania Ave., N.W
. Washington, DC 20460-0001 Lonza Inc
. 90 Boroline Road Allendale, NJ 07401, USA p. 1



# rY1kO .3337/11

Robert J
. Sloan Senior Manager ~" ` 1 710 Regulatory Compliance - Americas i"T? n Phone: (201) 316-9365 Fax: (201) 696-3569 '0 bob.sloan@lonza .com March 7, 2011 0 Attn: TSCA Section 4 40 CFR Part 799.5087 ,-r

In compliance with the final rule, "Testing of Certain High Production Volume Chemicals; Second Group of Chemicals", 76FR1067, January 17, 2011, Lonza Inc
. submits this Letter of Intent to test for "1 H,3HBenzo[1,2-c:4,5-c']difuran-1,3,5,7-tetrone", CAS number 89-32-7
. Lonza Inc
. intends to either obtain EPA approval to waive the requirements and/or conduct the required testing and/or submit existing data to meet all the required endpoints as outlined in the final rule
. The company plans to conduct the testing, submit existing data or submit information supporting a waiver of the requirement for the following endpoints
. A3: Vapor Pressure A4: n-Octanol/Water Partition Coefficient (log 10 basis) or log KOW A5: Water Solubility B: Inherant Biodegradation C1 : Aquatic Toxicity D : Mammalian Toxicity -- Acute E1 : Mammalian Toxicity -- Genotoxicity F1 : Mammalian toxicity -- repeated dose/ reproduction/ developmental I~-+ ® The company believes that sufficient data exists to meet the following endpoint
. The company will submit this data along with, if necessary, a request to modify the testing requirements to match the conditions under which the data was developed
. E1 : Mammalian Toxicity -- Genotoxicity The following relevant data is available from literature (HSDB-, RTECS-Databases etc.) or QSARestimation
. The company will submit this data or references to this data along with requests to modify the testing requirements for the following endpoints: A3 : Vapor pressure (EPI-suite estimation / EPA 2003) A4 : Partition coefficient log (EPI-suite estimation / EPA 2003) A5: Water solubility (EPI-suite estimation / EPA 2003) D: Acute oral toxicity (Lit: various) 

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The companywill conduct the following testing to meet the following endpoints: B: Inherant Biodegradation 

## CONTAINS NOC!p. 2

The company will conductthe following testing to meet the following endpoints or provide adequate justification to support EPA approval of a waiver: F1 : Mammalian toxicity -- repeated dose/ reproduction/ developmental The companywill conduct the following testing to determine if othertesting requirements might be waived
. The companywill submit a formal Test Plan upon completion of this study: Abiotic degradation : Hydrolysis as a function of pH- OECD 111 If the hydrolysis 1/2 life is very short, the company will request a waiver for the following testing requirement
. If the hydrolysis rate is not short, the companywill conduct the following testing to meet the following endpoint : C1 : Aquatic Toxicity The contact information for the corporation and contact person filing this letter of intent to test and the primary contact for this testing is provided below
. Robert Sloan Lonza Inc
. 90 Boroline Road Allendale, NJ 07401 USA Telephone 201-316-9365 Fax 201-696-3569 Email : bob
.sloanCc~lonza.com If you have any questions, please contact me and at the number provided above
. Sincerely,


# 4t -- Robert J
. o Senior nager, Regulatory Compliance - Americas