Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

MEMORANDUM

DATE: May 1, 2013

SUBJECT: Indoxacarb Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for the Section 3 Registration Action on Dry Beans, 

Succulent Beans, Small Fruit Vine Climbing Subgroup (except kiwifruit) 13-07F 

and Low Growing Berry Subgroup (except strawberry) 13-07H. 

PC Code: 067710 DP Barcode: D408983

Decision No.: 464583 Registration No.: 352-597

Petition No.: 2E8029 Regulatory Action: Section 3

Risk Assessment Type: Single Chemical /Aggregate Case No.: NA

TXR No.: NA CAS No.: 173584-44-6

MRID No.: NA 40 CFR:180.564

REVIEWER: Ideliz Negrón-Encarnación, Ph.D., Chemist

Risk Assessment Branch V

Health Effects Division (7509P)

 

THROUGH: Douglas Dotson, Ph.D., Chemist

Kristin Rury, Chemist

Dietary Exposure Science Advisory Council (DESAC)

TO: Danette Drew, Senior Chemist

Risk Assessment Branch V

Health Effects Division (7509P)

and

Barbara Madden, Team Leader

Risk Integration Minor Use, and Emergency Response Branch

Registration Division (7505P)
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

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Executive Summary

Acute and chronic dietary risk assessments for indoxacarb were conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) 

Version 3.16, which uses food consumption data from the U.S. Department of Agriculture’s 

National Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA) from 2003 to 2008. The last dietary risk assessment for indoxacarb was 

conducted on 18-Feb-2009 (S. Tadayon; D360559) and the chronic was further refined on 13-May2009 (S. Tadayon; D364939). The acute and chronic dietary risk assessment has been updated to 

support the proposed Section 3 registrations on dry beans, succulent beans, Small fruit vine 

climbing subgroup (except kiwifruit) 13-07F and Low growing berry subgroup (except strawberry) 

13-07H. This memorandum was reviewed by two peer reviewers of the DESAC per SOP 2012.1.

Refined acute probabilistic and chronic dietary exposure assessments were conducted for existing 

and proposed new food uses of indoxacarb and drinking water. A cancer dietary exposure 

assessment was not conducted for indoxacarb, because indoxacarb has been classified as “not 

likely to be carcinogenic.” Anticipated residues (ARs) for all registered and proposed food 

commodities were based on field trial data (FTD) or tolerance level residues. When necessary, 

ARs for all current uses were further refined using percent crop treated (%CT) data (A. Halvorson, 

05-Apr-2007, D338731) following the guidance provided in HED Standard Operating Procedure 

(SOP) 99.6 (Classification of Food Forms with Respect to level of Blending; 20-Aug-1999). 

Available processing data for indoxacarb were used to refine ARs for apples/pears (juice), potato 

(dry, chips), cotton (oil), tomato (paste and puree), peanut (oil), soybean (oil), grapes (raisin and 

juice), prunes (dried), and mint (oil), and other commodities where translation was applicable. 

DEEM-FCID (ver. 7.81) default processing factors (PFs) were assumed for all other processed 

commodities for which these have been established.

EDWCs were provided by EFED (C. Koper, D402100, 06-Nov-2012) and incorporated directly

into the DEEM-FCID analyses. Both the acute and chronic analyses were conducted using 

estimated surface water residues generated using the Pesticide Root Zone/Exposure Analysis 

Modeling System (PRZM/EXAMS). 

 

Estimated acute dietary exposure to indoxacarb from food and drinking water is below HED’s 

level of concern (i.e. < 100% aPAD) for all population subgroups. Combined dietary exposure 

from food and drinking water at the 99.9th percentile of exposure is estimated to be 0.032762

mg/kg/day for the overall U.S. population equivalent to 27% of the aPAD. The population 

subgroup with the highest estimated acute dietary exposure to indoxacarb is all infants (< 1 year 

old), with an estimated exposure at the 99.9th percentile of 0.058294 mg/kg/day, equivalent to 49% 

of the aPAD. 

Estimated chronic dietary exposure to indoxacarb from food and drinking water is below HED’s 

level of concern (i.e. < 100% cPAD). Combined dietary exposure from food and drinking water is 
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

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estimated at 0.001133 mg/kg/day for the general U.S. population (5.7% of the chronic populationadjusted dose (cPAD) and 0.002381 mg/kg/day (12% of the cPAD) for children, 1 to 2 years old, 

the population subgroup with the highest estimated chronic dietary exposure to indoxacarb.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and 

chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the 

dose that HED has concluded will result in no unreasonable adverse health effects). This dose is 

referred to as the population adjusted dose (PAD). The PAD is equivalent to the point of departure 

(POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more 

detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-Jun-2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-Aug1999).

II. Residue Information

Indoxacarb is an oxadiazine insecticide used for control of lepidopteran pests on a variety of fruit, 

vegetable and field crops. Tolerances for the combined residues of indoxacarb + its R-enantiomer 

are published in 40 CFR §180.564. There are currently two end-use products of indoxacarb with 

food/feed uses registered to DuPont: a 30% water-dispersible granular (WDG) formulation 

(DuPont Avaunt Insecticide, EPA Reg. No. 352-597) and a 1.25 lb/gal (15%) suspension 

concentrate (SC) formulation (DuPont Steward®Insecticide, EPA Reg. No. 352-598). These 

formulations contain an isomeric mixture of 75% indoxacarb (insecticidally active S-enantiomer; 

DPX-KN128) and 25% of the R-enantiomer (insecticidally inactive; IN-KN127). The percentage 

of active ingredient (a.i.) listed on each label and the labeled use rates for each crop are based only

on the amount of indoxacarb. 

Residues of Concern: The nature of the residue in plants and livestock is adequately understood. 

Data from the plant and ruminant metabolism studies, as well as toxicological and environmental 

fate data were presented to the HED Metabolism Assessment Review Committee (MARC) for 

determination of the residues of concern (S. Levy, 10-Jul-2000; D263986). Indoxacarb and its Renantiomer were the relevant residues of concern to be established for the tolerance enforcement 

and risk assessment in plants. MARC has determined that the tolerance expression for milk, 

ruminant and poultry commodities will include indoxacarb and its R-enantiomer. The residues of 

concern for risk assessment in milk will also include the metabolite IN-MP819; and in poultry the 

metabolites IN-JT333, IN-JU873, IN-KB687, IN-KG433, IN-KT319, 5-HO-IN-JT333, and 
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Metabolite F will be included as well. Refer to DP# 324855 for the chemical structures of 

indoxacarb and its metabolites.

Tolerances: Permanent tolerances have been established under 40 CFR §180.564(a) for the 

combined residues of indoxacarb + its R-enantiomer as follows: Apple, wet pomace (3.0 ppm); 

Alfalfa, forage (10 ppm); Alfalfa, hay (50 ppm); Beet, garden, roots (0.30 ppm); Beet, garden, tops 

(6.0 ppm); Bushberry subgroup 13-07B (1.5 ppm); Cattle, fat (1.5 ppm); Cattle, meat (0.05 ppm); 

Cattle, meat byproducts 0.03; Corn, sweet, forage (10 ppm); Corn, sweet, kernel plus cob with 

husk removed (0.02 ppm); Corn, sweet, stover (15 ppm); Cotton, gin byproducts (15 ppm); Cotton, 

undelinted seed (2.0 ppm); Cranberry (0.90 ppm); Fruit, pome, except pear, group 11 (1.0 ppm); 

Fruit, stone, group 12 (0.90 ppm); Goat, fat (1.5 ppm); Goat, meat (0.05 ppm); Goat, meat 

byproducts 0.03; Grain, aspirated fractions (45 ppm); Grape (2.0 ppm); Grape, raisin (5.0 ppm); 

Hog, fat (1.5 ppm); Hog, meat (0.05 ppm); Hog, meat byproducts (0.03 ppm); Horse, fat (1.5 

ppm); Horse, meat (0.05 ppm); Horse, meat byproducts (0.03 ppm); Milk (0.15 ppm); Milk, fat 

(4.0 ppm); Okra (0.50 ppm); Pea, southern, seed (0.10 ppm); Peanut (0.01 ppm); Peanut, hay (40 

ppm); Pear (0.20 ppm); Pear, oriental (0.20 ppm); Peppermint, tops (11 ppm); Sheep, fat (1.5 

ppm); Sheep, meat (0.05 ppm); Sheep, meat byproducts (0.03 ppm); Soybean, hulls (4.0 ppm); 

Soybean, seed (0.80 ppm); Spearmint, tops (11 ppm); Turnip, greens (12 ppm); Vegetable, 

Brassica, leafy, group 5 (12 ppm); Vegetable, cucurbit, group 9 (0.60 ppm); Vegetable, fruiting, 

group 8 (0.50 ppm); Vegetable, leafy, except Brassica, group 4 (14 ppm); Vegetable, tuberous and 

corm, subgroup 1-C (0.01 ppm). 

DuPont has proposed tolerances for indoxacarb on dry beans and succulent beans. In addition, the 

Interregional Research Project No. 4 (IR-4) proposes tolerances for Small fruit vine climbing 

subgroup (except kiwifruit) 13-07F and Low growing berry subgroup (except strawberry) 13-07H 

based on the current tolerances for grapes and cranberry. The proposed tolerances are summarized 

below in Table 1 together with HED’s recommendations based on review of the residue data 

submitted to support these petitions (I. Negron, D408982, xx-Feb-2013).

Table 1. Tolerance Summary for Indoxacarb.

Commodity Established/Proposed 

Tolerance (ppm)

HED-Recommended 

Tolerance (ppm)

Comments (correct 

commodity definition)

Bean, dry, seed 0.07 0.2

Pea, southern, seed 0.1 Remove

Bean, succulent 0.64 0.9

Bean, forage 37 50 Cowpea, forage

Cowpea, hay NA 100

Small fruit vine climbing, 

except fuzzy kiwifruit, 

subgroup 13-07F

2.0 2

Low growing berry, except 

strawberry, subgroup 13-07H

0.9 1

Cranberry 0.90 Remove

Grape 2.0 Remove
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Residue Data used for the Acute and Chronic Assessments: 

Food Commodities (except livestock commodities): Refined acute probabilistic and chronic dietary

exposure assessments were conducted for all existing and proposed food uses of indoxacarb and 

drinking water. ARs for all registered and proposed food commodities were based on tolerance 

level residues or field trial data (FTD). When a commodity had a number of <LOQ residue values, 

either the highest FTD or tolerance was used for ease of calculation (i.e., for apples, the corrected 

highest field trial value was used for the “treated” commodity, instead of constructing a RDF with 

the full distribution of corrected values). ARs for some current uses were further refined using 

%CT data, following the guidance provided in HED SOP 99.6 (Classification of Food Forms with 

Respect to level of Blending; 20-Aug-1999). 100% CT was assumed for the remaining uses. 

Available processing data were used to refine ARs for apples/pears (juice), potato (dry, chips), 

cotton (oil), tomato (paste and puree), peanut (oil), soybean (oil), grapes (raisin and juice), prunes 

(dried), and mint (oil), and commodities were translated as appropriate. For all other processed 

commodities, DEEM-FCID (ver. 7.81) default PFs were assumed.

Acute Assessment:

 For non-blended and partially blended commodities: Tolerance level residues or the 

highest residue from the field trial data was used. Alternatively, a residue-distribution file 

(RDF) was constructed using the entire distribution of field trial residue values. If further 

refinement was needed, the tolerance level, highest residue, or RDF was adjusted to

incorporate zeros to account for the untreated portion of the crop (untreated portion = 100% 

minus the estimated maximum %CT). The resulting residue distributions were used 

probabilistically in the acute assessment. All PFs were inserted in DEEM-FCID under 

“adjustment factor 1.”

 For blended commodities: A point estimate was calculated by using the average or highest 

field trial residue. If refinement was needed, the point estimate was adjusted by the 

maximum %CT estimate (point estimate = residue level x maximum %CT). All PFs were 

inserted in DEEM-FCID under “adjustment factor 1.”

Chronic Assessment:

 For non-blended, partially blended and blended commodities: Tolerance level, highest or 

average residue was used. If further refinement was needed, the average %CT was used. 

All PFs were inserted in DEEM-FCID under “adjustment factor 1” while the fCT 

(fraction of crop treated, %CT/100) was inserted under “adjustment factor 2.”

Livestock commodities: For poultry, egg and milk, since the residues of concern for risk 

assessment were different than those in the tolerance expression, the metabolism study, in 

conjunction with feeding studies was used to calculate the secondary residues in those tissues (see 
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detail discussion later in this section). For ruminant and hog tissues, since the tolerance expression 

was the same as the residues of concern, the tolerance values were used as conservative estimates 

of the indoxacarb residues.

The food residue data used in the acute and chronic dietary assessments are summarized in Table 2.

RDFs used in the acute assessment are included in the attachments to this document.

Table 2. Data and Residue Estimates Used in the Acute and Chronic Dietary Analyses

Commodity Classifi

cation

Ave.

% CT

Max

% CT Source of Data # of FTD

# of 

zeroes in

RDF

sum 

(FTD)

mean of 

RDF or 

FTD1

PF Acute 

Value

Chronic

Value

apple juice PB 5 10 highest FTD 

(DP#: 244253) 1 9 0.74 0.074 0.01 rdf x PF 0.74 x fCT x PF

apples NB 5 10 highest FTD 

(DP#: 244253) 1 9 0.74 0.074 rdf 0.74 x fCT

apples, dried B 5 10 highest FTD 

(DP#: 244253) 1 9 0.74 0.074 8 0.074 x PF 0.74 x fCT x PF

Apricot PB 100 100 peach FTD (DP#: 

325479) 30 0 4.66 0.155 rdf 0.155

Apricot, 

dried B 100 100 FTD(DP#: 325479) 30 0 4.66 0.155 6 0.155 x PF 0.155 x PF

Bean, guar 

seed B 100 100 Dry Bean Tol / Ave Residue 13 NA 0.01 0.10 0.01

Bean (the 

rest) PB 100 100 Succulent Bean Tolerance 9 NA 0.18 0.90 0.18

Beet Garden 

Roots NB/PB 100 100 FTD(DP# 351087) 10 0 1.64 0.16 rdf 0.16

Beet Garden 

Tops PB 100 100 FTD(DP# 351087) 10 0 24.69 2.47 rdf 2.47

Subgroup

(13B) PB 100 100 FTD(DP# 351087) 26 0 14.8 0.57 rdf 0.57

Broccoli NB 50 70

FTD 

(DP#: 244253) 20 8 12.95 0.4625 rdf 0.648 x fCT

Cabbage

(no wrapper) NB 25 35

FTD 

(DP#: 244253) 24 40 1.27 0.0205 rdf 0.0577 x fCT

Cantaloupe NB 100 100 FTD 

(DP#: 325479) 22 0 2.236 0.1016 rdf 0.1016

Cauliflower NB 50 70 broccoli FTD 20 8 12.95 0.464 rdf 0.648 x fCT

Celeryuntrimmed PB 100 5FTD

(DP#: 325479) 12 0 23.2 1.9333 rdf 1.93

Cherry PB 1 2.5 FTD

(DP#: 325479) 32 1248 8 0.0063 rdf 0.25 x fCT

Cherry juice PB 1 2.5 FTD 

(DP#: 325479) 32 1248 8 0.0063 1.5 rdf x PF 0.25 x fCT x PF

Corn, sweet NB 2.5 10 highest FTD 

(DP#: 244253) 1 9 0.008 0.0008 rdf 0.008 x fCT

Cottonseed 

oil B 100 100 highest FTD (DP#: 244253) 1 NA 0.67 0.67 0.04 0.67 x PF 0.67 x PF

Cranberry PB 100 100 FTD 

(DP#: 325479) 12 0 2.591 0.2159 rdf 0.2160

Cranberry PB 100 100 FTD 

(DP#: 325479) 12 0 2.591 0.2159 rdf x PF 0.2160 x PF

Cucumber NB 100 100 FTD 

(DP#: 325479) 20 0 0.459 0.0230 rdf 0.023
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

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Table 2. Data and Residue Estimates Used in the Acute and Chronic Dietary Analyses

Commodity Classifi

cation

Ave.

% CT

Max

% CT Source of Data # of FTD

# of 

zeroes in

RDF

sum 

(FTD)

mean of 

RDF or 

FTD1

PF Acute 

Value

Chronic

Value

Eggs NB 100 100 see text 1 NA 0.119 0.119 0.119 0.119

Group 8, the 

rest (okra, 

eggplant, 

tomatillo)

PB 100 100

highest tomato 

FTD 

(DP#: 244253)

1 NA 0.27 0.27 0.27 0.27

Grape PB 100 1

FTD 

(DP#: 290126) 20 0 10.06 0.5030 rdf 0.503

Grape 

juice/wine PB 100 1

FTD 

(DP#: 290126) 20 0 10.06 0.5030 0.007 rdf x PF 0.503 x PF

Grape leaves PB 100 100 FTD 

(DP#: 290126) 20 0 10.06 0.5030 rdf 0.503

Grape raisins PB 100 1

FTD

(DP#: 290126) 20 0 10.06 0.5030 2.7 rdf x PF 0.5030 x PF

Group 11, 

except apples 

and pears

NB 100 100

highest FTD for 

apples

(DP#: 244253)

1 0 0.74 0.7400 rdf 0.74

Lettuce head, 

no wrapper

NB 10 35 18 33 3.97 0.0778 rdf 0.22 x fCT

Lettuce, leaf NB 10 35 DP#: 244253 18 33 108.2 2.12 rdf 6.01 x fCT

Milk fat PB 100 1-2.5 see text 1 NA 3.28 3.28 2.43 0.026

Milk water PB 100 100 see text 1 NA 0.11 0.11 0 0

Milk, non-fat 

solids PB 100 1-2.5 see text 1 NA 0.29 0.29 0.495 0.0052

Mint B 100 100 FTD 

(DP#: 325479) 12 NA 46.44 3.87 3.87 3.87

Mint oil B 100 100 12 NA 46.44 3.87 0.028 3.87 x PF 3.87 x PF

Mustard 

Green PB 100 100 FTD (DP#: 325479) 8 0 47.8 5.975 rdf 5.975

Nectarine PB 100 100 Peach FTD (DP#:

325479) 30 0 4.66 0.1553 rdf 0.1553

Peach NB 2.5 2.5 FTD 

(DP#: 325479) 30 1170 4.66 0.0039 rdf 0.155 x fCT

Peach Dried B 2.5 2.5 FTD 

(DP#: 325479) 30 NA 4.66 0.0039 4 0.0039 x PF 0.155 x fCT

Peanut B 2.5 10 highest FTD 

(DP#: 244253) 1 NA 0.003 0.0003 0.0003 0.003 x fCT

Peanut butter B 2.5 10 highest FTD 

(DP#: 244253) 1 NA 0.003 0.0003 1.89 0.0003 x PF 0.003 x fCT xPF

Peanut oil B 2.5 10 highest FTD 

(DP#: 244253) 1 NA 0.003 0.0003 1.4 0.0003 x PF 0.003 x fCT x PF

Pear NB 1 2.5 highest FTD 

(DP#: 244253) 1 39 0.08 0.002 rdf 0.08 x fCT

Pear juice PB 1 2.5 highest FTD 

(DP#: 244253) 1 39 0.08 0.002 0.01 rdf x PF 0.08 x fCT x PF

Pears, dried B 1 2.5 highest FTD 

(DP#: 244253) 1 NA 0.08 0.002 6.25 0.002 x PF 0.08 x fCT x PF

Pepper (bell 

or non-bell) PB 15 30 highest FTD (DP#: 244253) 30 70 1.005 0.0201 rdf 0.067
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Table 2. Data and Residue Estimates Used in the Acute and Chronic Dietary Analyses

Commodity Classifi

cation

Ave.

% CT

Max

% CT Source of Data # of FTD

# of 

zeroes in

RDF

sum 

(FTD)

mean of 

RDF or 

FTD1

PF Acute 

Value

Chronic

Value

Pepper, dried B 15 30 highest FTD 

(DP#: 244253) 30 70 1.005 0.0201 0.0201 0.067

Pepper, dry

(bell or nonbell)B 15 30 highest FTD 

(DP#: 244253) 15 70 1.005 0.0201 0.0201 0.067

Plums-prunes NB 100 100 FTD

(DP#: 325479) 22 0 0.99 0.0450 rdf 0.045

Plums-prunes

(dried) PB 100 100 FTD (DP#: 325479) 22 NA 0.99 0.0450 4 0.045 x PF 0.045 x PF

Pork NB 100 100 Tolerance tolerance tolerance

Pork, fat NB 100 Tolerance (a) 

/Anticip Res (c) tolerance 0.016

Potato NB 1 2.5 FTD/Tolerance 1 39 0.01 0.00025 rdf 0.01 x fCT

Potato

(dry, chips) B 1 2.5 average FTD 1 NA 0.004 0.0001 0.85 0.0001 x PF 0.004 x fCT x PF

Potato, flour B 1 2.5 average FTD 1 NA 0.004 0.0001 0.0001 0.004 x fCT 

Poultry, fat NB 100 100 see text 0.457 0.457

Poultry, liver NB 100 100 see text 0.052 0.052

Poultry, meat NB 100 100 see text 0.045 0.045

Poultry, meat 

byproduct NB 100 100 see text 0.052 0.052

Poultry, skin NB 100 100 see text 0.079 0.079

Ruminants NB 100 100 tolerance tolerance tolerance

Ruminants, 

fat NB 100 Tolerance (a) /Anticip Res (c) tolerance 0.016

Soybean B 1 2.5 average FTD 1 NA 0.088 0.0022 0.64 (for 

oil) .0022 x PF 0.088 x fCTx PF

Spinach NB 2.5 5

FTD 

(DP#: 325479) 16 304 84.3 0.2634 rdf 5.27 x fCT

Squash NB 100 100 FTD 

(DP#: 325479) 22 0 0.729 0.0331 rdf 0.0331

Subgroup 

1C, except 

potato

NB 100 100 tolerance 1 NA 0.01 0.01 0.01 0.01

Subgroup 

4A, the rest 

(not spinach 

& lettuce)

NB 100 100 FTD 

(DP#: 325479) 16 0 84.3 5.2688 rdf 5.27

Subgroup 4B NB 100 100 Celery FTD 

(DP#: 325479) 12 0 23.2 1.9333 rdf 1.93

Subgroup 

5A, except 

broccoli and 

cabbage

PB 50 70 broccoli FTD 20 8 12.95 0.4625 rdf 0.648 x fCT

Subgroup 5B PB 100 100

Mustard green 

FTD 

(DP#: 325479)

8 0 47.8 5.9750 rdf 5.9750

Subgroup 

9A, melons NB 100 100 Cantaloupe FTD (DP#: 325479) 22 0 2.236 0.1016 rdf 0.1016

Subgroup 9B 

except 

cucumber

NB 100 100

summer squash 

FTD 

(DP#: 325479)

22 0 0.729 0.0331 rdf 0.0331
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Table 2. Data and Residue Estimates Used in the Acute and Chronic Dietary Analyses

Commodity Classifi

cation

Ave.

% CT

Max

% CT Source of Data # of FTD

# of 

zeroes in

RDF

sum 

(FTD)

mean of 

RDF or 

FTD1

PF Acute 

Value

Chronic

Value

Tomatoes PB 20 40 highest FTD 

(DP#: 244253) 25 37 6.75 0.108 rdf 0.27 x fCT

Tomatoes, 

dried B 20 40 highest FTD (DP#: 244253) 25 37 6.75 0.108 14.3 0.108 x PF 0.27 x fCT x PF

Tomatoes, 

paste B 20 40 highest FTD (DP#: 244253) 25 37 6.75 0.108 1.4 0.108 x PF 0.27 x fCT x PF

Tomatoes, 

puree

B 20 40 highest FTD 

(DP#: 244253) 25 37 6.75 0.108 0.52 0.108 x PF 0.27 x fCT x PF

Subgroup 8, 

except 

tomato and 

pepper

20 40 highest FTD 

(DP#: 244253) 1 NA NA 0.27 0.27 0.27 

Water (all 

sources) see text 0.05926 0.01848

NA = Not applicable

1 The mean of the RDF or FTD may be adjusted by the maximum %CT.

2 When the highest or mean FTD is used, the #FTD may be set higher than one in order to obtain an integer for the # of zeros in rdf.

Food Residues – Details

Note that for the chronic assessment further refinement was performed to support the aggregate 

risk assessment (food and residential).

Bean, guar seed: The tolerance and average residue of dry beans was used as a point estimate for 

acute and chronic assessments, respectively, since guar seed is exclusively under the dry beans

section of the proposed label. All the remaining beans are under dry and/or succulent bean section 

of the label; therefore, the highest residue corresponding to the succulent commodity was used in 

the dietary assessment, see below.

Bean (the rest): The tolerance and average residue of succulent bean was used as a point estimate 

for acute and chronic assessments, respectively.

Bushberries (blueberries): RDF and average field trial data were used as a point estimate for acute 

and chronic assessments, respectively. 

Beet, Garden (roots and tops): RDF and average field trial data were used as a point estimate for 

acute and chronic assessments, respectively. 

Vegetables, leafy, except Brassica, group 4: The submitted field trials for celery and spinach were 

conducted at different pre-harvest intervals (PHIs) (celery at 7-, 14-, and 21-day PHIs while 

spinach at 3-, 7-, and 14-day PHIs). The proposed label for leafy petiole vegetables (celery is in 

subgroup 4B) lists 3-day PHI, 3-day retreatment interval (RTI), maximum seasonal application of 

0.26 lb ai/A. Note that data are not available for untrimmed celery at the proposed PHI of 3 days. 

However, HED used the trimmed celery residue data to estimate untrimmed celery residues as 
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follows: Indoxacarb residue concentrations in trimmed and untrimmed celery were compared for 

0-day, 7-day, and 14-day PHI samples. Based on this comparison, trimmed to untrimmed ratios 

were determined to be 2.32 for the 0-day PHI samples, 3.0 for the 7-day PHI samples and 2.3 for 

the 14-day PHI samples. The average residue ratio for these three sampling intervals was 

calculated to be 2.5. The 3-day trimmed celery residue data were entered into the MRL calculator, 

resulting in a trimmed celery tolerance of 3.5 ppm. To determine an untrimmed tolerance value, 

the 3.5 ppm value was multiplied by the average trimmed to untrimmed residue ratio of 2.5, 

resulting in a value of ~9.0 ppm.

Therefore, for celery, the trimmed, 3-day PHI celery FTD were multiplied by 2.5 and used in an 

RDF (Indoxacarb-040907-3-dayPHI-UntrimdCelery.rdf). This RDF, with assumption of 100% CT 

was used for all subgroup 4B crops (leaf petiole vegetables). For the chronic assessment, the 

average of the celery FTD and average %CT were used.

For lettuce and spinach, their corresponding FTD and %CT were used in three separate RDFs (leaf 

lettuce, head lettuce and spinach). The crops had the same use rates (4 applications, maximum use 

rate – 0.26 lb ai/A, 3-day PHI). For the remaining RACs of crop subgroup 4A (leafy greens 

subgroup), spinach FTD with 100% CT assumptions were used. The average residue value and 

%CT were used in the chronic assessment. 100% of CT was assumed for all crops other than 

lettuce and spinach.

Brassica, leafy, group 5: Broccoli, cabbage, and mustard green FTD are available (S. Levy, 19-

Jan-2000, DP#: 244253 and 18-Feb-2005, DP#: 290126) and were within 5x of each other, with 

mustard green FTD being the highest. The suggested use rate is the same for all crops in this group 

(maximum application rate = 0.26 lb ai/A, PHI=3 days). Broccoli field trials were not conducted at 

a 1x application rate; therefore, broccoli FTD were used for broccoli only after being adjusted for 

rate of exaggeration (multiplied by 0.67; see DP#: 244253, page 119) and cabbage FTD were used 

for cabbage only. For the rest of the crop subgroup 5A, broccoli FTD (higher residues than 

cabbage) adjusted for zeroes with %CT for broccoli (highest %CT in that subgroup and in all 

crops), were used. The average residue value and %CT were used for subgroup 5A in the chronic 

assessment. For crop subgroup 5B, mustard green FTD with 100% CT were used (no %CT on any

of the crops in subgroup 5B are available). The average residue value and 100%CT was assumed 

for crop subgroup 5B in the chronic assessment.

Cranberry: The submitted FTD with assumption of 100% CT were used in an RDF. The average 

field trial value was used in the chronic assessment. The DEEM-FCID default PF for cranberry

juice (1.1) was used.

Cottonseed oil: The average FTD and the empirical PF (0.04x) as adjustment factor were used.

Corn: The highest FTD were used in an RDF incorporating zeroes corresponding to %CT. For the 

chronic assessment, the highest field trial value and average %CT were used.
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Cucurbit Vegetables (group 9): Cantaloupe, summer squash, and cucumber FTD with 100% CT 

assumptions were used for group 9 crops. Cantaloupe data were used for all melons (subgroup 9A) 

and summer squash data (higher than cucumber data) were utilized for all crops in subgroup 9B 

except for cucumber. For the chronic assessment, average field trial data with 100% CT 

assumptions were used.

Fruiting Vegetables (group 8): FTD were submitted for non-bell pepper, bell pepper, and 

tomatoes (S. Levy, 19-Jan-2000, DP#: 244253), with residues being highest for tomatoes. The 

highest FTD residue for both non-bell pepper and bell pepper which was adjusted for the rate 

exaggeration was 0.067 ppm and that for tomato FTD was 0.27 ppm. These values and the average 

%CT were used in the chronic assessment. For the acute assessment, two RDFs were generated for 

pepper and tomatoes, using their highest FTD and incorporating the available %CT values; these

RDFs were used for corresponding crops. For the rest of this group (eggplant, tomatillo, and okra), 

the highest FTD for tomatoes (0.27 ppm) were used in the chronic and acute assessments, as well 

as 100% CT assumptions. Empirical PFs for tomato paste (1.4x) and puree (0.52x) were used. 

The PF for tomato puree (0.52x) was also used for tomato juice. The DEEM-FCID default PF 

for dried tomato (14.3x) was used.

Fruit Stone, group 12: FTD for cherries, peaches, and plums with the same use rate were 

submitted; FTD residues were highest for cherries. The registrant requested four applications with 

a maximum use of 0.44 lb ai/A and 14-day PHI. The submitted FTD were used for the respective 

crops in DEEM-FCID as (in form of RDFs). For other crops in group 12, FTD for the similar 

fruit were used. %CT data were only available for cherries and peaches which were incorporated 

in their respective RDFs. The average FTD and %CT were used for cherries and peaches in the 

chronic assessment. For other crops in group 12, 100% CT were assumed. An empirical PF of 4x 

was used for dried plums. For the other crops in group 12, DEEM-FCID default PFs were used 

for juice and the dried food form.

Grape, grape juice, raisins: Grape FTD with 100% CT assumptions were used to construct an 

RDF for grape, grape juice and raisins. The average field trial residue and average %CT was used 

in the chronic assessment. PFs (as adjustment factors in DEEM-FCID) were also incorporated 

(PF for grape juice/wine and sherry=0.007, PF for raisins=2.7).

Mint: The average of the submitted mint FTD were used as a point estimate (assuming 100% CT) 

for peppermint, spearmint, and their corresponding oil in the acute and chronic assessments. Mint 

and mint oil are considered blended commodities. An empirical PF (0.028x) was used for mint oil.

Pome Fruit group (11):

Apple, apple juice, dried apple: The highest FTD for apple which were adjusted for rate of 

exaggeration (0.74 ppm) were used in an RDF. The RDF also incorporated zeroes according to 

%CT. For the chronic assessment, the highest field trial data and average %CT were used. An 

empirical PF of 0.01 was used for apple juice, and a DEEM-FCID default PF of 8 was used for 
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dried apple. 

Pear, pear juice, dried pear: The highest FTD for pear which were adjusted for rate of 

exaggeration (0.08 ppm) were used in an RDF. The RDF also incorporated zeroes according to 

%CT. For the chronic assessment, the highest field trial data and average %CT were used. A PF 

for apple juice (0.01) was translated to pear juice, and a DEEM-FCID default PF of 6.25 was 

used for dried pear.

For the rest of the crops in group 11, the apple RDF with the same %CT was used in the acute 

assessment while the highest field trial value was used in the chronic assessment with 100% CT 

assumptions.

Peanut, peanut butter, peanut oil: All are considered blended commodities. The highest FTD for 

peanut (0.003 ppm) with % CT were used to derive a point estimate for acute. For chronic, the 

highest field trial value with average %CT was used. An empirical PF of 1.4x was used for peanut 

oil and DEEM-FCID default PF of 1.89x was used for peanut butter.

Soybean: Since all the soybean food forms are blended, the average FTD (0.088 ppm) (S. Levy, 

30-MAY-2002; DP#: 276516) were used as a point estimate in conjunction with PF (0.64x for 

soybean oil only) and %CT value.

Tuberous and corm vegetables, subgroup 1C: 

Potato: For non-blended food forms, a tolerance-level residue (0.01 ppm) was used in the RDF 

with inserting zeroes according to %CT value. The tolerance level and average %CT were used in 

the chronic assessment. For blended food forms (dry potato, chips, flour), the average field trial 

value (0.004 ppm) adjusted for the %CT, and PFs (0.85x for chips and dry potato) were used (S. 

Levy, 30-May-2002; D276516).

The tolerance level residue (0.01 ppm), with assumption of 100% CT were used for the rest of the 

crops in subgroup 1C.

Livestock Commodities - Details

Poultry: From the poultry metabolism study, the ratios of all the metabolites of concern to those

that were measured in the feeding study were calculated to be: 1.81 for egg yolk, 2.8 for fat, 1.5 for 

muscle, 2.5 for liver, and 1.8 for skin (DP#: 244253). These ratios were multiplied by estimated 

measured residues in each tissue in the feeding study to arrive at the total metabolites of concern. 

The following dietary burden in conjunction with the feed-tissue chart was used to estimate the 

measured residues in each tissue. As per HED policy, residues in poultry tissues were not adjusted 

for % dry matter (DM). The calculated dietary burden is 2.72 ppm (electronic communication, J. 

Stokes, 17-Apr-2007).
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Table 3. Calculation of Poultry Dietary Burden.

Feedstuff %DM Classification Tolerance % In Diet Dietary Burden

Corn, grain

NA

CC40 70 0

Wheat, grain CC 0 5 0

Soybean, meal1PC50.8 15 0.12

Cottonseed, meal2PC 2.0 5 0.10

Alfalfa, meal3PC 50 5 2.50

Total 100 2.72

1 Based on soybean seed tolerance

2 Based on undelinted cottonseed tolerance

3 Based on alfalfa hay tolerance

4 CC = carbohydrate concentrate

5 PC = protein concentrate

The estimated residues of concern were used as a point estimate in DEEM-FCID for the 

corresponding poultry tissues in both acute and chronic assessments, assuming 100% CT. The 

estimated residue value in poultry liver tissue was used for meat by-product tissues. Refer to M. 

Sahafeyan (DP # 339398; 23-May-2007) for the anticipated residue calculations.

Ruminants (beef, goat, sheep, and horse) and Pork: Corresponding tolerance values as point 

estimates (assuming 100% CT) were used for both acute and chronic assessments for all ruminant 

commodities with the exception of ruminant fat and milk for which anticipated residues were 

calculated to support the chronic assessment. 

In order to refine the chronic assessment anticipated residues in milk and ruminant fat were 

estimated using dietary burden calculations that incorporated highest or average residues and 

average %CT. A livestock dietary burden calculator developed by HED was used to estimate the 

dietary burden for dairy cattle, and then the % crop treated was incorporated. Since average 

residues in feedstuff commodities can be used to construct dietary burden to support chronic 

dietary assessment, the estimate below (8.78 ppm) is lower than that reported in the residue 

chemistry chapter (33.0 ppm). Moreover, incorporation of percent of crop treated estimates lead to 

lower dietary burden estimates (0.229 ppm). For the remaining ruminant commodities tolerance 

level residues were assumed.

Table 4. Refined Dietary Burden for Dairy Cattle to Support the Chronic Dietary Assessment of Indoxacarb. 

Feedstuff %DM Classific

ation1

Highest/ 

Average 

Residue2

% In Diet Dietary 

Burden

%Crop 

Treated

Refined 

Dietary 

Burden

Apples, Pomace, wet 40 CC 1.9 10 0.48 5 0.024

CC 35 (NU) 0.00

Cotton, undelinted seed 88 PC 1.3 10 0.15 1 0.001

Corn, sweet, forage 48 R 8.7 45 8.16 2.5 0.204

Total 100 8.78 0.229

1 CC = carbohydrate concentrate; PC = protein concentrate; R = roughage

2 The residue values used to determine the dietary burden are included in Attachment #5. 
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Milk: The dietary burden of 0.229 ppm is anticipated to result in 0.000573 ppm indoxacarb 

residue in whole milk based on the feeding study (D276518, 5/30/2002) and a constructed doseresidue chart (D339398, 5/23/2007). However, the residues of concern are indoxacarb and MP819. From metabolism study (D244253, p.141), the highest ratio of metabolites of concern to 

indoxacarb is 1.82; therefore, the estimated highest residues of concern in whole milk is 0.00104

ppm. Due to high lipophilicity of indoxacarb (KOW = 4.65 at pH 5) those residues are expected to 

be concentrated in the milk fat. Therefore, the residues in milk fat are estimated to be at 0.026 ppm 

(i.e., 0.00104 / 4%*100, assuming milk fat is 4% of whole milk). From the same feeding study

residues in cream and skim milk were also measured; however, the fat content of the cream is 

undetermined and thus, those data for cream can not be used. The expected indoxacarb residue in 

skim milk from the dose-residue chart is 0.000229 ppm; therefore, considering the residues of 

concern the expected residue is 0.00042 ppm (i.e., 0.000229*1.8). With the assumption that the 

residues are concentrated in non-fat solids of the skim milk (~ 8% of the milk w/w), the estimated 

residues in non-fat solids is 0.0052 ppm (i.e., 0.00042 / 8%*100). No residues are expected in 

milk water and lactose. Refer to M. Sahafeyan (DP # 339398; 23-May-2007) for the anticipated 

residue calculations.

Fat of ruminants (beef, goat, sheep, and horse) and pork: The dietary burden of dairy cattle is 

higher than that of beef cattle; therefore, is appropriate to base the anticipated residues in the 

former. The feeding study doesn’t show an increase of residue level with increase of dose 

administered; therefore, a linear regression is not appropriate in this case. Based on this the tissue 

to feed ratio was obtained from the 7.5 ppm dose which correspond to the highest and most 

conservative ratio. The anticipated residue in ruminant fat is 0.016 ppm (i.e. 0.229 * 0.52 / 7.5). 

Note that monitoring data from the 2009 Pesticide Data Program show no detects (0.05 ppm LOD) 

in 292 samples of adipose beef tissue.

III. Percent Crop Treated Information

The following maximum percent crop treated estimates (BEAD Report, October 12, 2012, 

Reporting Years: 2004-2011, see Attachment 4) were used in the acute dietary risk assessment for 

the following crops that are currently registered for indoxacarb: apples: 10%; broccoli: 70%, 

cabbage: 35%; cauliflower: 60%; cherries: 2.5%; lettuce: 40%; peaches: 2.5%; peanuts: 10%; 

pears: 2.5%; potatoes: 2.5%; soybeans: 2.5%; spinach: 5%; sweet corn: 10%; tomatoes: 40%. The 

following average percent crop treated estimates were used in the chronic dietary risk assessments 

Table 5. Residues of indoxacarb in fat from the feeding study with 

ruminants (D244253, S. Levy, 01/19/2000)

Dose (ppm) Residue of R- and S- enantiomers (ppm)

7.5 0.52

22.5 0.39

75 0.42
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for the following crops that are currently registered for indoxacarb apples: 5%; broccoli: 50%, 

cabbage: 25%; cauliflower: 40%; celery: 5%; cherries: 1%; grapes: 1%; lettuce: 10%; peaches: 

2.5%; peanuts: 2.5%; pears: 1%; potatoes: 1%; soybeans: 1%; spinach: 2.5%; sweet corn: 2.5%; 

tomatoes: 20%. For all other crop commodities with indoxacarb uses, including the proposed uses 

(dry bean, succulent bean and low growing berry subgroup (except strawberry) 13-07H), 100% of 

the crop treated was assumed.

IV. Drinking Water Data

Reference: C. Koper, D402100, 06-Nov-2012.

A Tier II screening-level drinking water assessment was conducted to support the human health 

risk assessment for the proposed new use registration for indoxacarb. Modeled application rates 

represent the maximum application rates from the proposed labels (DuPont TM Avaunt®, EPA Reg. 

No. 352-597 and DuPont TM Steward® EC, EPA Reg. No. 352-638) for use on dry beans, snap 

beans, small fruit vine climbing subgroup 13-07F and low-growing berry subgroup 13-07H. For 

dry and snap beans and the low-growing berry subgroup, the proposed maximum application rate is 

0.44 lbs. a.i./acre (4 applications at 0.11 lbs. a.i./acre). For cranberry and the small fruit vine 

climbing subgroup, the proposed maximum application rate is 0.22 lbs. a.i./acre (2 applications at 

0.11 lbs. a.i./acre). In addition, aerial and ground foliar spray applications and chemigation 

techniques are the proposed application methods. Based on the Metabolism Assessment Review 

Committee (MARC) recommendations, a Total Toxic Residue (TTR) approach was used for the 

parent indoxacarb and the degradation products with toxicological concern (IN-JT333, INKG4333, IN- KT413, IN-ML437-0H) for the drinking water assessment. 

The recommended estimated drinking water concentrations (EDWCs) for the human health risk 

assessment are based on highest predicted value for surface water and groundwater (Table 5), 

which are based on two applications of 0.11 lbs. a.i./acre/season on cranberry and four applications 

of 0.11 lbs. a.i./acre on beans and berries respectively. For acute and chronic dietary risk 

assessments, the 1-in -10 year peak (59.26 ppb) and the 1-in -10 year annual average, (18.48 ppb) 

indoxacarb residues of concern in water from cranberry scenario were used.

Table 5. Recommended Estimated Drinking Water Concentrations (EDWCs)1for Surface Water 

and Ground Water 

Drinking 

Water 

Source

Model

Scenario Method2

Maximum 

Application Rate

(interval between 

applications)

1-in-10 

year 

acute 

(μg/L)

1-in-10 

year 

chronic 

(μg/L)

30- year 

average 

(μg/L)

Surface Provisional Cranberry Model PCM 2 app @ 0.11 lb a.i./acre 59.26 18.48 18.48
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Table 5. Recommended Estimated Drinking Water Concentrations (EDWCs)1for Surface Water 

and Ground Water 

Drinking 

Water 

Source

Model

Scenario Method2

Maximum 

Application Rate

(interval between 

applications)

1-in-10 

year 

acute 

(μg/L)

1-in-10 

year 

chronic 

(μg/L)

30- year 

average 

(μg/L)

Water Cranberry

Ground 

Water

SCI-GROW

(Beans, Berries) -- 4 app @ 0.11 lb a.i./acre 0.33 0.33 0.33

1 For surface water (PRZM/EXAMS), EDWC values adjusted with a Percent Cropped Area (PCA) factor of 0.87. 

For ground water (SCI-GROW), no PCA adjustment was utilized. 

2 PCM = The Provisional Cranberry Model (PCM) is a provisional refinement to the Tier I Rice Model (v1.0, May 8, 

2007). Refinements include the addition of simple degradation processes in dry and flooded conditions and a water 

depth of twelve inches, rather than the water depth of four inches used in the rice model. These modifications allow 

estimation of screening-level peak and annual mean EDWCs of residues of concern that may occur in untreated 

surface water used as drinking water following use on cranberries.

V. DEEM-FCIDTM Program and Consumption Information

Indoxacarb acute and chronic dietary exposure assessments were conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, 

Version 3.16, which incorporates 2003 - 2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and 

survey respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 

3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average 

daily consumption estimate for that food/food form to produce a residue intake estimate. The 

resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total average 

estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the 

cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 
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individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant 

commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

VI. Toxicological Information

Table 6 below summarizes the HED decisions on endpoints as related to the dietary risk 

assessment as adapted from the Human Health Risk Assessment (D. Drew, D402099, In Progress).

Table 6. Summary of Toxicological Doses and Endpoints for Indoxacarb for Use in Dietary Exposure 

Assessment1.

Exposure

Scenario

Dose for Use in Risk 

Assessment,

UF

FQPA SF* and 

Level of Concern 

for Risk 

Assessment

Study and Toxicological Effects

Acute Dietary

females 13-49 years 

ofage

An endpoint of concern specific to females 13-49 and attributable to a single dose was not 

identified in the toxicity study data base, thus an acute RfD was not established.

Acute Dietary

general population

including infants and 

children

NOAEL= 12 mg/kg

UF = 100

Acute RfD = 0.12 mg/kg

UFA= 10x

UFH=10x

FQPA SF = 1x

aPAD = 

= 0.12 mg/kg

Acute oral rat neurotoxicity study.

LOAEL = 50 mg/kg based on 

decreased body weight and bodyweight gain in females (MP062)

Chronic Dietary

all populations

NOAEL= 2.0 mg/kg/day

UF = 100

Chronic RfD = 0.02 

mg/kg/day

UFA= 10x

UFH=10x

FQPA SF = 1x 

cPAD = 

= 0.02 mg/kg/day

Weight of evidence approach was 

used from four studies: 

1) Subchronic toxicity study- rat 

(MP062)

2) Subchronic neurotoxicity study 

- rat (MP062)

3) Chronic/carcinogenicity study -

rat (JW062)

4) Two generation rat 

reproduction study (JW062).

LOAEL = 3.3 mg/kg/day based on 

decreased body weight, bodyweight gain, food consumption 

and food efficiency; decreased 

hematocrit, hemoglobin and red 

blood cells only at 6 months.
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

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Cancer (oral, 

dermal,inhalation)

“Not likely” to be carcinogenic to humans since no evidence of carcinogenicity in either the 

rat or mouse studies, and no evidence of mutagenicity.

1

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark 

the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no 

observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from 

animal to human (interspecies). UFH = potential variation in sensitivity among members of the human population (intraspecies). 

UFL = use of a LOAEL to extrapolate a NOAEL. FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c 

= chronic). RfD = reference dose. N/A = not applicable.

VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the aPAD and cPAD, respectively. The DEEM-FCIDTM analyses estimate the dietary

exposure of the U.S. population and various population subgroups. The acute and chronic results 

reported in Tables 7 and 8 are for the general U.S. population, all infants (<1 year old), children 1-

2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years. 

Acute Dietary Exposure Results

 

Estimated acute dietary exposure to indoxacarb from food and drinking water is below HED’s 

level of concern for all population subgroups. Combined dietary exposure from food and drinking 

water at the 99.9th percentile of exposure is estimated to be 0.032762 mg/kg/day for the overall 

U.S. population, equivalent to 27% of the aPAD. The population subgroup with the highest 

estimated acute dietary exposure to indoxacarb is all infants, with an estimated exposure at the 

99.9th percentile of 0.058294 mg/kg/day, equivalent to 49% of the aPAD.

Table 7. Summary of Acute Dietary (Food + Drinking Water) Exposure and Risk for Indoxacarb

Population Subgroup aPAD 

(mg/kg/day)

95th Percentile 99th Percentile 99.9th Percentile

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

General U.S. Population

0.12

0.009954 8.3 0.017531 15 0.032762 27

All Infants (< 1 year old) 0.016632 14 0.023797 20 0.058294 49

Children 1-2 years old 0.021818 18 0.030424 25 0.054158 45

Children 3-5 years old 0.016529 14 0.026494 22 0.046841 39

Children 6-12 years old 0.010843 9 0.016818 14 0.035434 30

Youth 13-19 years old 0.006731 5.6 0.010642 8.9 0.025623 21

Adults 20-49 years old 0.007453 6.2 0.012442 10 0.025109 21

Adults 50+ years old 0.007340 6.1 0.013368 11 0.030965 26

Female 13-49 0.007511 6.3 0.013145 11 0.026456 22

The population subgroup with the highest estimated acute dietary (food + drinking water) exposure and risk is 

indicated by bold text.

Chronic Dietary Exposure Results
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Estimated chronic dietary exposure to indoxacarb from food and drinking water is below HED’s 

level of concern. Combined dietary exposure from food and drinking water is estimated at 

0.001133 mg/kg/day for the general U.S. population (5.7% of the cPAD) and 0.002381 mg/kg/day

(12% of the cPAD) for children, 1 to 2 years old, the population subgroup with the highest 

estimated chronic dietary exposure to indoxacarb.

Table 8. Summary of Chronic Dietary (Food + Drinking Water) Exposure and Risk for Indoxacarb.

Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) % cPAD

General U.S. Population

0.02

0.001133 5.7

All Infants (< 1 year old) 0.001772 8.9

Children 1-2 years old 0.002381 12

Children 3-5 years old 0.001818 9.1

Children 6-12 years old 0.001105 5.5

Youth 13-19 years old 0.000743 3.7

Adults 20-49 years old 0.001036 5.2

Adults 50+ years old 0.001165 5.8

Females 13-49 years old 0.001037 5.2

The population subgroup with the highest estimated chronic dietary (food + drinking water) exposure and risk is 

indicated by bold text.

Results of the acute and chronic dietary assessment are summarized in Table 9.

Table 9. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Indoxacarb

Population Subgroup

Acute Dietary

(99.9 Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population 0.032762 27 0.001133 5.7

All Infants (<1 year old) 0.058294 49 0.001772 8.9

N/A N/A

Children 1-2 years old 0.054158 45 0.002381 12

Children 3-5 years old 0.046841 39 0.001818 9.1

Children 6-12 years old 0.035434 30 0.001105 5.5

Youth 13-19 years old 0.025623 21 0.000743 3.7

Adults 20-49 years old 0.025109 21 0.001036 5.2

Adults 50+ years old 0.030965 26 0.001165 5.8

Females 13-49 years old 0.026456 22 0.001037 5.2

*The subpopulation(s) with the highest risk estimates (Insert an asterisk after the population subgroups with the highest 

risk estimates and highlight the subpopulations in bold print)

VIII. Characterization of Inputs and Outputs
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These analyses are considered to be refined dietary exposure assessments. In some cases, 

tolerance-level residues, empirical processing factors, default DEEM processing factors, and/or 

100% CT data were used. Refinement was conducted for some commodities by using field trial 

data and %CT assumptions. Anticipated residues in milk and ruminant fat were calculated to 

further refine the chronic risk assessment and support the aggregate assessment (dietary and 

residential exposure). Further refinement of residue levels for some commodities could be made 

through the use of ARs, and incorporation of %CT and/or monitoring data that better reflect 

residues at the time of consumption. Since both acute and chronic risk estimates are below HED’s 

level of concern, more highly refined analyses are not needed at this time.

It is noted that the consumption database used in the current assessment is based on data obtained 

in surveys conducted from 2003 to 2008 (NHANES/WWEIA) while the database used in the 

previous assessment (S. Tadayon; D360559, 18-Feb-2009 for acute and D364939, 13-May-2009 

for chronic) was based on surveys conducted from 1994-1996 and 1998 (USDA’s Continuing 

Surveys of Food Intakes by Individuals). The consumption database used is reflective of the most

current consumption patterns and may result in different exposures for some commodities. 

IX. Conclusions

The results of the acute and chronic dietary assessments indicate that dietary exposure to 

indoxacarb from food and drinking water is below HED’s level of concern for the general U.S. 

population and all population subgroups. HED is confident that the assessments do not 

underestimate risk to the general U.S. population or any population subgroup. 

X. List of Attachments

 RDFs for the Acute Analysis

 Acute Food plus Water Residue Input file and Acute Results file.

 Chronic Food plus Water Residue Input file and Chronic Results file.

 Percent Crop Treated Memo from BEAD.
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 21 of 41

Attachment 1: RDFs for the Acute Analysis

RDF 1

Apple, highest adjusted FTD 

(D244253, p.128)=0.74

ToTALZ= 9

doc max %CT=10%

1,0.74

RDF 2

Indoxacarb, Blueberry 

doc max CT=100%

totalz=0

0.20

0.27

0.28

0.30

0.32

0.35

0.38

0.38

0.42

0.51

0.52

0.53

0.55

0.56

0.58

0.58

0.59

0.63

0.73

0.80

0.81

0.81

0.84

0.84

1.03

1.04

RDF 3

Indoxacarb-Broccoli

doc Max %CT=70%

ToTALZ=8

doc adjusted for exaggeration 

rate(multiplied by 0.67) (MRID 44477401)

0.19

0.23

1.34

1.5

0.57

0.62

0.25

0.45

1.34

1.68

0.80

RDF 4

Indoxacarb-subgroup 5A, 

Broccoli FTD, 

doc Max %CT=70% of 

Broccoli (highest)

ToTALZ=8

doc adjusted for exaggeration 

rate(multiplied by 0.67) 

(MRID 44477401)

0.19

0.23

1.34

1.5

0.57

0.62

0.25

0.45

1.34

1.68

0.80

0.94

0.26

0.52

0.36

0.49

0.23

0.26

0.38

0.54
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 22 of 41

0.94

0.26

0.52

0.36

0.49

0.23

0.26

0.38

0.54

RDF 5

Indoxacarb-Cabbage without 

Wrapper Leaves

doc Max %CT=35%

ToTALZ=44

0.02

0.04

0.01

0.03

0.08

0.11

0.05

0.05

0.03

0.07

0.06

0.1

0.01

0.02

0.11

0.21

0.02

0.03

0.03

0.04

0.02

0.02

0.03

0.08

RDF 6

Indox-Cherries, 46651504.der

doc max CT= 2.5

Totalz=1248

.07

.07

.15

.45

.22

.19

.15

.16

.3

.51

.24

.12

.26

.31

.13

.62

.07

.07

.15

.45

.21

.19

.15

.15

.32

.51

.28

.15

.26

.32

.13

.64

RDF 7

Indoxacarb, Mustard Green 

FTD, PHI=3 days, D290126, 

45718701.der

doc max CT=100%

totalz=0

3.5

3.4

1.2

1.2

9.6

10

9.5

9.4
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 23 of 41

RDF 8

Indoxacarb - Head Lettuce w/o 

wrapper leaves

doc 40% CT Max (of lettuce)

TOTALZ=27

0.033

0.016

0.067

0.082

0.051

0.044

0.14

0.24

0.061

0.047

0.11

0.029

0.48

0.34

0.13

0.24

1.1

0.76

RDF 9

Indoxacarb - Leaf Lettuce

doc 40% CT Max (of lettuce)

TOTALZ=27

8

8.7

6.8

7.9

6.6

5.6

3.5

4.6

6.6

7.7

5.9

7.2

8.3

8.1

3.4

3.7

2.7

2.9

RDF 10

Indox-Peach FTD, 

46651505.der

ToTALZ=1170

doc max CT=2.5% 

.07

.26

.13

.03

.04

.1

.09

.3

.16

.19

.58

.07

.06

.29

.13

.04

.04

.3

.16

.2

.59

.07

.09

.09

.09

.09

.1

.1

.1

.1

RDF 11

Indox-Pear, highest FTD, D244253, 

p.128

doc max CT=2.5%

ToTALZ=39

0.08

RDF 12

Indox-tomato, highest adjusted FTD, 

D244253

ToTALZ=60

40,0.27

RDF 13

Indox-fruiting veg. besides 

pepper and tomatoes

doc highest adjusted FTD for 

tomatoes is used, D244253

ToTALZ=0

doc max % CT=100%

0.27

RDF 14

Indox-Corn Sweet(k+CWHR), 

adjusted highest FTD, D244253

RDF 15

Indox-pepper(bell or non-bell), FTD, 

D244253

RDF 18-20 blank
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 24 of 41

ToTALZ=9

doc max %CT=10

0.008

doc highest FTD used (adjusted for 

exaggeration)

doc max CT=30%

ToTALZ=70

30,0.067

RDF 21

Indox-Mint, FTD, 46520902.der

doc max CT=100%

totalz=0

6.84

5.9

5.3

6.81

3.61

2.62

2.24

2.73

2.18

2.1

2.75

3.36

RDF 22

Indox-Spinach FTD, 46487001.der

doc max CT=5%

totalz=304

7.9

13

2.5

4.5

3.7

3.3

5.7

5.7

4.7

4.3

4.3

4.2

7.2

6.7

2.2

4.4

RDF 23

Indox-Plum, FTD, 

46651506.der

doc max CT=100%

TotalZ=0

.01

.01

.02

.02

.02

.03

.07

.04

.07

.19

.02

.02

.01

.02

.02

.02

.03

.07

.04

.07

.18

.01

RDF 24

Indox-trimmed celery, FTD x 2.5, 

see p.14 of D325479

doc max CT=100%

totalz=0

0.155

0.145

3.25

3

1.075

1.375

1.9

1.325

1.05

RDF 25

Indox-southern pea, FTD, 46520901.der

doc max CT=100%

totalz=0

4,.01

.0670

.0630

.0130

.0140

.0110

.0110

.0330

.0200

.0150

RDF 26

Indoxacarb, Grapes, FTD, 

D290126, 45900301.der, 

PHI=7 days

doc max CT=100%

totalz=0

0.196

0.163

1.72

1.32

0.133

0.198

0.105
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 25 of 41

1.175

4.75

4

.0320 0.0661

0.306

0.328

0.448

0.423

0.292

0.0888

0.482

0.353

1.35

1.31

0.447

0.329

RDF 27

indox-squash, FTD, 

46651503.der

doc max CT=100%

totalz=0

0.12

.014

.11

.04

.01

.022

.035

.012

.026

.01

.01

.084

.013

.048

.032

.01

.034

.026

.013

.028

.01

.022

RDF 28

Indox-Cucumber, FTD, 46651502.der

doc max CT=100%

totalz=0

.018

.015

.025

.025

.01

.023

.04

.031

.013

.019

.016

.02

.028

.014

.01

.022

.069

.031

.012

.018

RDF 29

Indox-Cantaloupe, FTD, 

46651501.der

doc max CT=100%

totalz=0

0.027

0.247

0.13

.393

.088

.031

.05

.036

.05

.116

.018

.064

.197

.17

.23

.068

.022

.064

.035

.052

.124

.024

RDF 30

Indox-Apricot, Nectarine, 

used Peach FTD, 

46651505.der

ToTALZ=0

doc max CT=100%

RDF 31

Indox-cranberry, FTD, 46651507.der, PHI=28-30 

days

doc max CT=100%

totalz=0

.086

RDF 32

Indox-Spinach FTD, 

46487001.der used for rest of 

group 4A (100% CT 

assumption)

doc max CT=100%

totalz=0
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 26 of 41

.07

.26

.13

.03

.04

.1

.09

.3

.16

.19

.58

.07

.06

.29

.13

.04

.04

.3

.16

.2

.59

.07

.09

.09

.09

.09

.1

.1

.1

.1

.151

.099

.190

.13

.57

.146

.149

.11

.16

.11

.69

7.9

13

2.5

4.5

3.7

3.3

5.7

5.7

4.7

4.3

4.3

4.2

7.2

6.7

2.2

4.4

RDF 33

Indox-potato ; tolerance, 

D276516

doc max % CT=2.5

totalz=39

0.01

RDF 16

Indoxacarb, garden beet root

doc max CT=100%

totalz=0

0.11

0.12

0.12

0.13

0.18

0.18

RDF 17

Indoxacarb, garden beet tops 

doc max CT=100%

totalz=0

1.31

1.31

1.86

1.88

2.15

2.23
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 27 of 41

0.18

0.19

0.21

0.22

3.01

3.28

3.70

3.96
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 28 of 41

Attachment 2: Acute Food plus Water Residue Input File and Result File

Filename: C:\Documents and Settings\iencarna\My Documents\DEEM Version 

3.16\Indoxacarb\INDOXACARB_ACUTE.R08

Chemical: Indoxacarb

RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .12 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 04-30-2013/16:17:14 Program ver. 3.16, 03-08-d

Comment: EDWC 0.0593 ppm

-----------------------------------------------------------------------------------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

 # Code 

----- ---- ------------ -------- -------- -------

 1 6 Indoxacarb-041207-apple.rdf

 2 6 indoxacarb-Blueberry-FTD.rdf

 3 6 Indoxacarb-041207-broccoli.rdf

 4 6 Indoxacarb-041207-Grp5A-rest.rdf

 5 6 Indoxacarb-041107-cabbage-WithoutWrapper.rdf

 6 6 Indoxacarb-040907-cherries.rdf

 7 6 indoxacarb-040307-MustrdGrn-FTD.rdf

 8 6 Indoxacarb-041107-HeadLettuce-NoWrapper.rdf

 9 6 Indoxacarb-041707-LeafLettuce.rdf

 10 6 Indoxacarb-040907-peach.rdf

 11 6 Indoxacarb-041207-pear.rdf

 12 6 Indoxacarb-041507-tomato.rdf

 13 6 Indoxacarb-041507-FruitgVeg.rdf

 14 6 Indoxacarb-041707-sweet-corn.rdf

 15 6 Indoxacarb-041507-Pepper.rdf

 16 6 indoxacarb-garden beet root-FTD.rdf

 17 6 indoxacarb-garden beet top-FTD.rdf

 18 6 Indoxacarb-blank3.rdf

 19 6 Indoxacarb-blank4.rdf

 20 6 Indoxacarb-blank5.rdf

 21 6 Indoxacarb-041007-mint.rdf

 22 6 indoxacarb-040907-spinach.rdf

 23 6 Indoxacarb-040907-plum.rdf

 24 6 Indoxacarb-040907-3-dayPHI-UntrimdCelery.rdf

 25 6 Indoxacarb-040907-southern-pea.rdf

 26 6 indoxacarb-040307-grapeFTD.rdf

 27 6 Indoxacarb-041007.squash.rdf

 28 6 Indoxacarb-041007-cucumber.rdf

 29 6 Indoxacarb-041007-cantaloupe.rdf

 30 6 Indoxacarb-040907-Apricot-Nectarine.rdf

 31 6 Indoxacarb-041007-cranberry.rdf

 32 6 indoxacarb-042307-Grp-4A-rest.rdf

 33 6 Indoxacarb-042307-potato.rdf

 EPA Crop Commodity Name Def Res Adj.Factors RDLComment

 Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- -------

0101050000 1AB Beet, garden, roots 0.300000 1.000 1.000 16 

0101050001 1AB Beet, garden, roots-babyfood 0.300000 1.000 1.000 16 

0103015000 1CD Arrowroot, flour 0.010000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.010000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 

0103082000 1CD Cassava 0.010000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.010000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.010000 1.000 1.000 

0103166000 1CD Ginger 0.010000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.010000 1.000 1.000 

0103167000 1CD Ginger, dried 0.010000 1.000 1.000 

0103296000 1C Potato, chips 0.000100 0.850 1.000 Blende

 Full comment: Blended, %CT unknown

0103297000 1C Potato, dry (granules/ flakes) 0.000100 0.850 1.000 Blende

 Full comment: Blended

0103297001 1C Potato, dry (granules/ flakes)-b 0.000100 0.850 1.000 Blende
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 29 of 41

 Full comment: Blended

0103298000 1C Potato, flour 0.000100 1.000 1.000 Blende

 Full comment: Blended

0103298001 1C Potato, flour-babyfood 0.000100 1.000 1.000 Blende

 Full comment: Blended

0103299000 1C Potato, tuber, w/peel 0.010000 1.000 1.000 33 

0103299001 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000 33 

0103300000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 33 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000 33 

0103366000 1CD Sweet potato 0.010000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.010000 1.000 1.000 

0103371000 1CD Tanier, corm 0.010000 1.000 1.000 

0103387000 1CD Turmeric 0.010000 1.000 1.000 

0103406000 1CD Yam, true 0.010000 1.000 1.000 

0103407000 1CD Yam bean 0.010000 1.000 1.000 

0200051000 2 Beet, garden, tops 6.000000 1.000 1.000 17 

0401005000 4A Amaranth, leafy 14.000000 1.000 1.000 32 

0401018000 4A Arugula 14.000000 1.000 1.000 32 

0401104000 4A Chrysanthemum, garland 14.000000 1.000 1.000 32 

0401133000 4A Cress, garden 14.000000 1.000 1.000 32 

0401134000 4A Cress, upland 14.000000 1.000 1.000 32 

0401138000 4A Dandelion, leaves 14.000000 1.000 1.000 32 

0401150000 4A Endive 14.000000 1.000 1.000 32 

0401204000 4A Lettuce, head 14.000000 1.000 1.000 8 

0401205000 4A Lettuce, leaf 14.000000 1.000 1.000 9 

0401248000 4A Parsley, leaves 14.000000 1.000 1.000 32 

0401313000 4A Radicchio 14.000000 1.000 1.000 32 

0401355000 4A Spinach 14.000000 1.000 1.000 22 

0401355001 4A Spinach-babyfood 14.000000 1.000 1.000 22 

0402076000 4B Cardoon 14.000000 1.000 1.000 24 

0402085000 4B Celery 14.000000 1.000 1.000 24 

0402085001 4B Celery-babyfood 14.000000 1.000 1.000 24 

0402086000 4B Celery, juice 14.000000 1.000 1.000 24 

0402087000 4B Celtuce 14.000000 1.000 1.000 24 

0402152000 4B Fennel, Florence 14.000000 1.000 1.000 24 

0402322000 4B Rhubarb 14.000000 1.000 1.000 24 

0402367000 4B Swiss chard 14.000000 1.000 1.000 24 

0501061000 5A Broccoli 12.000000 1.000 1.000 3 

0501061001 5A Broccoli-babyfood 12.000000 1.000 1.000 3 

0501062000 5A Broccoli, Chinese 12.000000 1.000 1.000 3 

0501064000 5A Brussels sprouts 12.000000 1.000 1.000 4 

0501069000 5A Cabbage 12.000000 1.000 1.000 5 

0501071000 5A Cabbage, Chinese, napa 12.000000 1.000 1.000 4 

0501072000 5A Cabbage, Chinese, mustard 12.000000 1.000 1.000 4 

0501083000 5A Cauliflower 12.000000 1.000 1.000 4 

0501196000 5A Kohlrabi 12.000000 1.000 1.000 4 

0502063000 5B Broccoli raab 12.000000 1.000 1.000 7 

0502070000 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 7 

0502117000 5B Collards 12.000000 1.000 1.000 7 

0502194000 5B Kale 12.000000 1.000 1.000 7 

0502229000 5B Mustard greens 12.000000 1.000 1.000 7 

0502318000 5B Rape greens 12.000000 1.000 1.000 7 

0502389000 5B Turnip, greens 12.000000 1.000 1.000 7 

0600347000 6 Soybean, seed 0.002200 1.000 1.000 Blende

 Full comment: Blended

0600349000 6 Soybean, soy milk 0.002200 1.000 1.000 Blende

 Full comment: Blended

0600349001 6 Soybean, soy milk-babyfood or in 0.002200 1.000 1.000 Blende

 Full comment: Blended

0600350000 6 Soybean, oil 0.002200 0.640 1.000 Blende

 Full comment: Blended

0600350001 6 Soybean, oil-babyfood 0.002200 0.640 1.000 Blende

 Full comment: Blended

0601043000 6A Bean, snap, succulent 0.900000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.900000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.900000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.900000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.900000 1.000 1.000 
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 30 of 41

0603030000 6C Bean, black, seed 0.900000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.900000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.900000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.900000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.900000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.900000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.900000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.900000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.900000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.900000 1.000 1.000 

0603098000 6C Chickpea, seed 0.900000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.900000 1.000 1.000 

0603099000 6C Chickpea, flour 0.900000 1.000 1.000 

0603182000 6C Guar, seed 0.100000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.100000 1.000 1.000 

0603348000 6C Soybean, flour 0.002200 1.000 1.000 Blende

 Full comment: Blended

0603348001 6C Soybean, flour-babyfood 0.002200 1.000 1.000 Blende

 Full comment: Blended

0801374000 8A Tomatillo 0.270000 1.000 1.000 

0801375000 8A Tomato 0.500000 1.000 1.000 12 

0801375001 8A Tomato-babyfood 0.500000 1.000 1.000 12 

0801376000 8A Tomato, paste 0.108000 1.400 1.000 Blende

 Full comment: Blended

0801376001 8A Tomato, paste-babyfood 0.108000 1.400 1.000 Blende

 Full comment: Blended

0801377000 8A Tomato, puree 0.108000 0.520 1.000 Blende

 Full comment: Blended

0801377001 8A Tomato, puree-babyfood 0.108000 0.520 1.000 Blende

 Full comment: Blended

0801378000 8A Tomato, dried 0.108000 14.300 1.000 Blende

 Full comment: Blended

0801378001 8A Tomato, dried-babyfood 0.108000 14.300 1.000 Blende

 Full comment: Blended

0801379000 8A Tomato, juice 0.500000 0.520 1.000 12 

0802148000 8BC Eggplant 0.270000 1.000 1.000 

0802234000 8BC Okra 0.270000 1.000 1.000 

0802270000 8B Pepper, bell 0.500000 1.000 1.000 15 

0802270001 8B Pepper, bell-babyfood 0.500000 1.000 1.000 15 

0802271000 8B Pepper, bell, dried 0.020100 1.000 1.000 Blende

 Full comment: Blended

0802271001 8B Pepper, bell, dried-babyfood 0.020100 1.000 1.000 Blende

 Full comment: Blended

0802272000 8BC Pepper, nonbell 0.500000 1.000 1.000 15 

0802272001 8BC Pepper, nonbell-babyfood 0.500000 1.000 1.000 15 

0802273000 8BC Pepper, nonbell, dried 0.020100 1.000 1.000 Blende

 Full comment: Blended

0901075000 9A Cantaloupe 0.600000 1.000 1.000 29 

0901187000 9A Honeydew melon 0.600000 1.000 1.000 29 

0901399000 9A Watermelon 0.600000 1.000 1.000 29 

0901400000 9A Watermelon, juice 0.600000 1.000 1.000 29 

0902021000 9B Balsam pear 0.600000 1.000 1.000 27 

0902088000 9B Chayote, fruit 0.600000 1.000 1.000 27 

0902102000 9B Chinese waxgourd 0.600000 1.000 1.000 27 

0902135000 9B Cucumber 0.600000 1.000 1.000 28 

0902308000 9B Pumpkin 0.600000 1.000 1.000 27 

0902309000 9B Pumpkin, seed 0.600000 1.000 1.000 27 

0902356000 9B Squash, summer 0.600000 1.000 1.000 27 

0902356001 9B Squash, summer-babyfood 0.600000 1.000 1.000 27 

0902357000 9B Squash, winter 0.600000 1.000 1.000 27 

0902357001 9B Squash, winter-babyfood 0.600000 1.000 1.000 27 

1100007000 11 Apple, fruit with peel 1.000000 1.000 1.000 1 

1100008000 11 Apple, peeled fruit 1.000000 1.000 1.000 1 

1100008001 11 Apple, peeled fruit-babyfood 1.000000 1.000 1.000 1 

1100009000 11 Apple, dried 0.074000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.074000 8.000 1.000 

1100010000 11 Apple, juice 1.000000 0.010 1.000 1 

1100010001 11 Apple, juice-babyfood 1.000000 0.010 1.000 1 
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 31 of 41

1100011000 11 Apple, sauce 1.000000 1.000 1.000 1 

1100011001 11 Apple, sauce-babyfood 1.000000 1.000 1.000 1 

1100129000 11 Crabapple 1.000000 1.000 1.000 1 

1100210000 11 Loquat 1.000000 1.000 1.000 1 

1100266000 11 Pear 0.110000 1.000 1.000 11 

1100266001 11 Pear-babyfood 0.110000 1.000 1.000 11 

1100267000 11 Pear, dried 0.002000 6.250 1.000 Blende

 Full comment: Blended

1100268000 11 Pear, juice 0.110000 0.010 1.000 11 

1100268001 11 Pear, juice-babyfood 0.110000 0.010 1.000 11 

1100310000 11 Quince 1.000000 1.000 1.000 1 

1201090000 12A Cherry 0.900000 1.000 1.000 6 

1201090001 12A Cherry-babyfood 0.900000 1.000 1.000 6 

1201091000 12A Cherry, juice 0.900000 1.500 1.000 6 

1201091001 12A Cherry, juice-babyfood 0.900000 1.500 1.000 6 

1202012000 12B Apricot 0.900000 1.000 1.000 30 

1202012001 12B Apricot-babyfood 0.900000 1.000 1.000 30 

1202013000 12B Apricot, dried 0.155300 6.000 1.000 

1202014000 12B Apricot, juice 0.900000 1.000 1.000 30 

1202014001 12B Apricot, juice-babyfood 0.900000 1.000 1.000 30 

1202230000 12B Nectarine 0.900000 1.000 1.000 30 

1202260000 12B Peach 0.900000 1.000 1.000 10 

1202260001 12B Peach-babyfood 0.900000 1.000 1.000 10 

1202261000 12B Peach, dried 0.003900 4.000 1.000 

1202261001 12B Peach, dried-babyfood 0.003900 4.000 1.000 

1202262000 12B Peach, juice 0.900000 1.000 1.000 10 

1202262001 12B Peach, juice-babyfood 0.900000 1.000 1.000 10 

1203285000 12C Plum 0.900000 1.000 1.000 23 

1203285001 12C Plum-babyfood 0.900000 1.000 1.000 23 

1203286000 12C Plum, prune, fresh 0.900000 1.000 1.000 23 

1203286001 12C Plum, prune, fresh-babyfood 0.900000 1.000 1.000 23 

1203287000 12C Plum, prune, dried 0.900000 4.000 1.000 23 Partia

 Full comment: Partially blended

1203287001 12C Plum, prune, dried-babyfood 0.900000 4.000 1.000 23 Partia

 Full comment: Partially blended

1203288000 12C Plum, prune, juice 0.900000 1.400 1.000 23 

1203288001 12C Plum, prune, juice-babyfood 0.900000 1.400 1.000 23 

1302057000 13B Blueberry 1.500000 1.000 1.000 2 

1302057001 13B Blueberry-babyfood 1.500000 1.000 1.000 2 

1302136000 13B Currant 1.500000 1.000 1.000 2 

1302137000 13B Currant, dried 1.500000 1.000 1.000 2 

1302149000 13B Elderberry 1.500000 1.000 1.000 2 

1302174000 13B Gooseberry 3.000000 1.000 1.000 2 

1302191000 13B Huckleberry 1.500000 1.000 1.000 2 

1304175000 13D Grape 3.000000 1.000 1.000 26 

1304176000 13D Grape, juice 3.000000 0.007 1.000 26 

1304176001 13D Grape, juice-babyfood 3.000000 0.007 1.000 26 

1304179000 13D Grape, wine and sherry 3.000000 1.000 1.000 26 

1307130000 13G Cranberry 1.000000 1.000 1.000 31 

1307130001 13G Cranberry-babyfood 1.000000 1.000 1.000 31 

1307131000 13G Cranberry, dried 1.000000 1.000 1.000 31 

1307132000 13G Cranberry, juice 1.000000 1.100 1.000 31 

1307132001 13G Cranberry, juice-babyfood 1.000000 1.100 1.000 31 

1500127000 15 Corn, sweet 0.020000 1.000 1.000 14 

1500127001 15 Corn, sweet-babyfood 0.020000 1.000 1.000 14 

2003128000 20C Cottonseed, oil 0.670000 0.040 1.000 Blende

 Full comment: Blended

2003128001 20C Cottonseed, oil-babyfood 0.670000 0.040 1.000 Blende

 Full comment: Blended

3100044000 31 Beef, meat 0.050000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.030000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.030000 1.000 1.000 

3100047000 31 Beef, fat 1.500000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 1.500000 1.000 1.000 

3100048000 31 Beef, kidney 0.030000 1.000 1.000 

3100049000 31 Beef, liver 0.030000 1.000 1.000 
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 32 of 41

3100049001 31 Beef, liver-babyfood 0.030000 1.000 1.000 

3200169000 32 Goat, meat 0.050000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.030000 1.000 1.000 

3200171000 32 Goat, fat 1.500000 1.000 1.000 

3200172000 32 Goat, kidney 0.030000 1.000 1.000 

3200173000 32 Goat, liver 0.030000 1.000 1.000 

3300189000 33 Horse, meat 0.050000 1.000 1.000 

3400290000 34 Pork, meat 0.050000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.050000 1.000 1.000 

3400291000 34 Pork, skin 1.500000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.030000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.030000 1.000 1.000 

3400293000 34 Pork, fat 1.500000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 1.500000 1.000 1.000 

3400294000 34 Pork, kidney 0.030000 1.000 1.000 

3400295000 34 Pork, liver 0.030000 1.000 1.000 

3500339000 35 Sheep, meat 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.030000 1.000 1.000 

3500341000 35 Sheep, fat 1.500000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 1.500000 1.000 1.000 

3500342000 35 Sheep, kidney 0.030000 1.000 1.000 

3500343000 35 Sheep, liver 0.030000 1.000 1.000 

3600222000 36 Milk, fat 2.430000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 2.430000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.500000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.500000 1.000 1.000 

4000093000 40 Chicken, meat 0.045000 1.000 1.000 

4000093001 40 Chicken, meat-babyfood 0.045000 1.000 1.000 

4000094000 40 Chicken, liver 0.052000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.052000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.052000 1.000 1.000 

4000096000 40 Chicken, fat 0.457000 1.000 1.000 

4000096001 40 Chicken, fat-babyfood 0.457000 1.000 1.000 

4000097000 40 Chicken, skin 0.079000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.079000 1.000 1.000 

5000382000 50 Turkey, meat 0.045000 1.000 1.000 

5000382001 50 Turkey, meat-babyfood 0.045000 1.000 1.000 

5000383000 50 Turkey, liver 0.052000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.052000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.052000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.052000 1.000 1.000 

5000385000 50 Turkey, fat 0.460000 1.000 1.000 

5000385001 50 Turkey, fat-babyfood 0.460000 1.000 1.000 

5000386000 50 Turkey, skin 0.079000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.079000 1.000 1.000 

6000301000 60 Poultry, other, meat 0.045000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.052000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.052000 1.000 1.000 

6000304000 60 Poultry, other, fat 0.457000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.079000 1.000 1.000 

7000145000 70 Egg, whole 0.119000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.119000 1.000 1.000 

7000146000 70 Egg, white 0.119000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.119000 1.000 1.000 

7000147000 70 Egg, yolk 0.119000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.119000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.059260 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.059260 1.000 1.000 

9500177000 O Grape, leaves 2.000000 1.000 1.000 26 

9500178000 O Grape, raisin 6.000000 2.700 1.000 26 

9500263000 O Peanut 0.000300 1.000 1.000 Blende

 Full comment: Blended

9500264000 O Peanut, butter 0.000300 1.890 1.000 Blende

 Full comment: Blended

9500265000 O Peanut, oil 0.000300 1.400 1.000 Blende

 Full comment: Blended

9500275000 O Peppermint 3.870000 1.000 1.000 21 
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 33 of 41

9500276000 O Peppermint, oil 3.870000 0.028 1.000 Blende

 Full comment: Blended

9500352000 O Spearmint 3.870000 1.000 1.000 21 

9500353000 O Spearmint, oil 3.870000 0.028 1.000 Blende

 Full comment: Blended

US EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for INDOXACARB NHANES 2003-2008 2-Day

Residue file: INDOXACARB_ACUTE.R08 Adjustment factor #2 NOT used.

Analysis Date: 04-30-2013/16:25:21 Residue file dated: 04-30-2013/16:17:14

RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 1000; RNG = MS VB

Run Comment: "EDWC 0.0593 ppm"

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.009954 8.30 0.017531 14.61 0.032762 27.30 

All Infants:

 0.016632 13.86 0.023797 19.83 0.058294 48.58 

Children 1-2:

 0.021818 18.18 0.030424 25.35 0.054158 45.13 

Children 3-5:

 0.016529 13.77 0.026494 22.08 0.046841 39.03 

Children 6-12:

 0.010843 9.04 0.016818 14.02 0.035434 29.53 

Youth 13-19:

 0.006731 5.61 0.010642 8.87 0.025623 21.35 

Adults 20-49:

 0.007453 6.21 0.012442 10.37 0.025109 20.92 

Adults 50-99:

 0.007340 6.12 0.013368 11.14 0.030965 25.80 

Female 13-49:

 0.007511 6.26 0.013145 10.95 0.026456 22.05
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 34 of 41

Attachment 3: Chronic Risk Assessment Input File and Result File

Filename: C:\Documents and Settings\iencarna\My Documents\DEEM Version 

3.16\Indoxacarb\INDOXACARB_CHRONIC.R08

Chemical: Indoxacarb

RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .12 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 04-30-2013/16:16:25 Program ver. 3.16, 03-08-d

Comment: EDWC 0.01848 ppm for chronic

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101050000 1AB Beet, garden, roots 0.160000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.160000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.010000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.010000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 

0103082000 1CD Cassava 0.010000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.010000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.010000 1.000 1.000 

0103166000 1CD Ginger 0.010000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.010000 1.000 1.000 

0103167000 1CD Ginger, dried 0.010000 1.000 1.000 

0103296000 1C Potato, chips 0.004000 0.850 0.010 

0103297000 1C Potato, dry (granules/ flakes) 0.004000 0.850 0.010 

0103297001 1C Potato, dry (granules/ flakes)-b 0.004000 0.850 0.010 

0103298000 1C Potato, flour 0.004000 1.000 0.010 

0103298001 1C Potato, flour-babyfood 0.004000 1.000 0.010 

0103299000 1C Potato, tuber, w/peel 0.010000 1.000 0.010 

0103299001 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 0.010 

0103300000 1C Potato, tuber, w/o peel 0.010000 1.000 0.010 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 0.010 

0103366000 1CD Sweet potato 0.010000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.010000 1.000 1.000 

0103371000 1CD Tanier, corm 0.010000 1.000 1.000 

0103387000 1CD Turmeric 0.010000 1.000 1.000 

0103406000 1CD Yam, true 0.010000 1.000 1.000 

0103407000 1CD Yam bean 0.010000 1.000 1.000 

0200051000 2 Beet, garden, tops 2.470000 1.000 1.000 

0401005000 4A Amaranth, leafy 5.270000 1.000 1.000 

0401018000 4A Arugula 5.270000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 5.270000 1.000 1.000 

0401133000 4A Cress, garden 5.270000 1.000 1.000 

0401134000 4A Cress, upland 5.270000 1.000 1.000 

0401138000 4A Dandelion, leaves 5.270000 1.000 1.000 

0401150000 4A Endive 5.270000 1.000 1.000 

0401204000 4A Lettuce, head 0.220000 1.000 0.100 

0401205000 4A Lettuce, leaf 6.010000 1.000 0.100 

0401248000 4A Parsley, leaves 5.270000 1.000 1.000 

0401313000 4A Radicchio 5.270000 1.000 1.000 

0401355000 4A Spinach 5.270000 1.000 0.025 

0401355001 4A Spinach-babyfood 5.270000 1.000 0.025 

0402076000 4B Cardoon 1.930000 1.000 1.000 

0402085000 4B Celery 1.930000 1.000 0.050 

0402085001 4B Celery-babyfood 1.930000 1.000 0.050 

0402086000 4B Celery, juice 1.930000 1.000 0.050 

0402087000 4B Celtuce 1.930000 1.000 1.000 

0402152000 4B Fennel, Florence 1.930000 1.000 1.000 

0402322000 4B Rhubarb 1.930000 1.000 1.000 

0402367000 4B Swiss chard 1.930000 1.000 1.000 

0501061000 5A Broccoli 0.648000 1.000 0.500 

0501061001 5A Broccoli-babyfood 0.648000 1.000 0.500 

0501062000 5A Broccoli, Chinese 0.648000 1.000 1.000 

0501064000 5A Brussels sprouts 0.648000 1.000 1.000 
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 35 of 41

0501069000 5A Cabbage 0.057700 1.000 0.250 

0501071000 5A Cabbage, Chinese, napa 0.057700 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 0.057700 1.000 1.000 

0501083000 5A Cauliflower 0.648000 1.000 0.400 

0501196000 5A Kohlrabi 0.648000 1.000 1.000 

0502063000 5B Broccoli raab 5.980000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 5.980000 1.000 1.000 

0502117000 5B Collards 5.980000 1.000 1.000 

0502194000 5B Kale 5.980000 1.000 1.000 

0502229000 5B Mustard greens 5.980000 1.000 1.000 

0502318000 5B Rape greens 5.980000 1.000 1.000 

0502389000 5B Turnip, greens 5.980000 1.000 1.000 

0600347000 6 Soybean, seed 0.088000 1.000 0.010 

0600349000 6 Soybean, soy milk 0.088000 1.000 0.010 

0600349001 6 Soybean, soy milk-babyfood or in 0.088000 1.000 0.010 

0600350000 6 Soybean, oil 0.088000 0.640 0.010 

0600350001 6 Soybean, oil-babyfood 0.088000 0.640 0.010 

0601043000 6A Bean, snap, succulent 0.180000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.180000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.180000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.180000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.180000 1.000 1.000 

0603030000 6C Bean, black, seed 0.180000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.180000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.180000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.180000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.180000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.180000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.180000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.180000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.180000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.180000 1.000 1.000 

0603098000 6C Chickpea, seed 0.180000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.180000 1.000 1.000 

0603099000 6C Chickpea, flour 0.180000 1.000 1.000 

0603182000 6C Guar, seed 0.010000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.010000 1.000 1.000 

0603348000 6C Soybean, flour 0.088000 1.000 0.010 

0603348001 6C Soybean, flour-babyfood 0.088000 1.000 0.010 

0801374000 8A Tomatillo 0.270000 1.000 1.000 

0801375000 8A Tomato 0.270000 1.000 0.200 

0801375001 8A Tomato-babyfood 0.270000 1.000 0.200 

0801376000 8A Tomato, paste 0.270000 1.400 0.200 

0801376001 8A Tomato, paste-babyfood 0.270000 1.400 0.200 

0801377000 8A Tomato, puree 0.270000 0.520 0.200 

0801377001 8A Tomato, puree-babyfood 0.270000 0.520 0.200 

0801378000 8A Tomato, dried 0.270000 14.300 0.200 

0801378001 8A Tomato, dried-babyfood 0.270000 14.300 0.200 

0801379000 8A Tomato, juice 0.270000 0.520 0.200 

0802148000 8BC Eggplant 0.270000 1.000 1.000 

0802234000 8BC Okra 0.270000 1.000 1.000 

0802270000 8B Pepper, bell 0.067000 1.000 0.150 

0802270001 8B Pepper, bell-babyfood 0.067000 1.000 0.150 

0802271000 8B Pepper, bell, dried 0.067000 1.000 0.150 

0802271001 8B Pepper, bell, dried-babyfood 0.067000 1.000 0.150 

0802272000 8BC Pepper, nonbell 0.067000 1.000 0.150 

0802272001 8BC Pepper, nonbell-babyfood 0.067000 1.000 0.150 

0802273000 8BC Pepper, nonbell, dried 0.067000 1.000 0.150 

0901075000 9A Cantaloupe 0.101600 1.000 1.000 

0901187000 9A Honeydew melon 0.101600 1.000 1.000 

0901399000 9A Watermelon 0.101600 1.000 1.000 

0901400000 9A Watermelon, juice 0.101600 1.000 1.000 

0902021000 9B Balsam pear 0.033100 1.000 1.000 

0902088000 9B Chayote, fruit 0.033100 1.000 1.000 

0902102000 9B Chinese waxgourd 0.033100 1.000 1.000 

0902135000 9B Cucumber 0.023000 1.000 1.000 

0902308000 9B Pumpkin 0.033100 1.000 1.000 

0902309000 9B Pumpkin, seed 0.033100 1.000 1.000 
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 36 of 41

0902356000 9B Squash, summer 0.033100 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.033100 1.000 1.000 

0902357000 9B Squash, winter 0.033100 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.033100 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.740000 1.000 0.050 

1100008000 11 Apple, peeled fruit 0.740000 1.000 0.050 

1100008001 11 Apple, peeled fruit-babyfood 0.740000 1.000 0.050 

1100009000 11 Apple, dried 0.740000 8.000 0.050 

1100009001 11 Apple, dried-babyfood 0.740000 8.000 0.050 

1100010000 11 Apple, juice 0.740000 1.300 0.050 

1100010001 11 Apple, juice-babyfood 0.740000 1.300 0.050 

1100011000 11 Apple, sauce 0.740000 1.000 0.050 

1100011001 11 Apple, sauce-babyfood 0.740000 1.000 0.050 

1100129000 11 Crabapple 0.740000 1.000 1.000 

1100210000 11 Loquat 0.740000 1.000 1.000 

1100266000 11 Pear 0.080000 1.000 0.010 

1100266001 11 Pear-babyfood 0.080000 1.000 0.010 

1100267000 11 Pear, dried 0.080000 6.250 0.010 

1100268000 11 Pear, juice 0.080000 0.010 0.010 

1100268001 11 Pear, juice-babyfood 0.080000 0.010 0.010 

1100310000 11 Quince 0.740000 1.000 1.000 

1201090000 12A Cherry 0.250000 1.000 0.010 

1201090001 12A Cherry-babyfood 0.250000 1.000 0.010 

1201091000 12A Cherry, juice 0.250000 1.500 0.010 

1201091001 12A Cherry, juice-babyfood 0.250000 1.500 0.010 

1202012000 12B Apricot 0.155000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.155000 1.000 1.000 

1202013000 12B Apricot, dried 0.155000 6.000 1.000 

1202014000 12B Apricot, juice 0.155000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.155000 1.000 1.000 

1202230000 12B Nectarine 0.155300 1.000 1.000 

1202260000 12B Peach 0.155000 1.000 0.025 

1202260001 12B Peach-babyfood 0.155000 1.000 0.025 

1202261000 12B Peach, dried 0.155000 4.000 0.025 

1202261001 12B Peach, dried-babyfood 0.155000 4.000 0.025 

1202262000 12B Peach, juice 0.155000 1.000 0.025 

1202262001 12B Peach, juice-babyfood 0.155000 1.000 0.025 

1203285000 12C Plum 0.045000 1.000 1.000 

1203285001 12C Plum-babyfood 0.045000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.045000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.045000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.045000 4.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.045000 4.000 1.000 

1203288000 12C Plum, prune, juice 0.045000 1.000 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.045000 1.000 1.000 

1302057000 13B Blueberry 0.570000 1.000 1.000 

1302057001 13B Blueberry-babyfood 0.570000 1.000 1.000 

1302136000 13B Currant 0.570000 1.000 1.000 

1302137000 13B Currant, dried 0.570000 1.000 1.000 

1302149000 13B Elderberry 0.570000 1.000 1.000 

1302174000 13B Gooseberry 0.570000 1.000 1.000 

1302191000 13B Huckleberry 0.570000 1.000 1.000 

1304175000 13D Grape 0.503000 1.000 0.010 

1304176000 13D Grape, juice 0.503000 0.007 0.010 

1304176001 13D Grape, juice-babyfood 0.503000 0.007 0.010 

1304179000 13D Grape, wine and sherry 0.503000 1.000 1.000 

1307130000 13G Cranberry 0.216000 1.000 1.000 

1307130001 13G Cranberry-babyfood 0.216000 1.000 1.000 

1307131000 13G Cranberry, dried 0.216000 1.000 1.000 

1307132000 13G Cranberry, juice 0.216000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 0.216000 1.100 1.000 

1500127000 15 Corn, sweet 0.008000 1.000 0.025 

1500127001 15 Corn, sweet-babyfood 0.008000 1.000 0.025 

2003128000 20C Cottonseed, oil 0.670000 0.040 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.670000 0.040 1.000 

3100044000 31 Beef, meat 0.050000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 37 of 41

3100046000 31 Beef, meat byproducts 0.030000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.030000 1.000 1.000 

3100047000 31 Beef, fat 0.016000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.016000 1.000 1.000 

3100048000 31 Beef, kidney 0.030000 1.000 1.000 

3100049000 31 Beef, liver 0.030000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.030000 1.000 1.000 

3200169000 32 Goat, meat 0.050000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.030000 1.000 1.000 

3200171000 32 Goat, fat 0.016000 1.000 1.000 

3200172000 32 Goat, kidney 0.030000 1.000 1.000 

3200173000 32 Goat, liver 0.030000 1.000 1.000 

3300189000 33 Horse, meat 0.050000 1.000 1.000 

3400290000 34 Pork, meat 0.050000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.050000 1.000 1.000 

3400291000 34 Pork, skin 0.016000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.030000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.030000 1.000 1.000 

3400293000 34 Pork, fat 0.016000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.016000 1.000 1.000 

3400294000 34 Pork, kidney 0.030000 1.000 1.000 

3400295000 34 Pork, liver 0.030000 1.000 1.000 

3500339000 35 Sheep, meat 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.030000 1.000 1.000 

3500341000 35 Sheep, fat 0.016000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.016000 1.000 1.000 

3500342000 35 Sheep, kidney 0.030000 1.000 1.000 

3500343000 35 Sheep, liver 0.030000 1.000 1.000 

3600222000 36 Milk, fat 0.026000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.026000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.005200 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.005200 1.000 1.000 

4000093000 40 Chicken, meat 0.045000 1.000 1.000 

4000093001 40 Chicken, meat-babyfood 0.045000 1.000 1.000 

4000094000 40 Chicken, liver 0.052000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.052000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.052000 1.000 1.000 

4000096000 40 Chicken, fat 0.457000 1.000 1.000 

4000096001 40 Chicken, fat-babyfood 0.457000 1.000 1.000 

4000097000 40 Chicken, skin 0.079000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.079000 1.000 1.000 

5000382000 50 Turkey, meat 0.045000 1.000 1.000 

5000382001 50 Turkey, meat-babyfood 0.045000 1.000 1.000 

5000383000 50 Turkey, liver 0.052000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.052000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.052000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.052000 1.000 1.000 

5000385000 50 Turkey, fat 0.457000 1.000 1.000 

5000385001 50 Turkey, fat-babyfood 0.457000 1.000 1.000 

5000386000 50 Turkey, skin 0.079000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.079000 1.000 1.000 

6000301000 60 Poultry, other, meat 0.045000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.052000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.052000 1.000 1.000 

6000304000 60 Poultry, other, fat 0.457000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.079000 1.000 1.000 

7000145000 70 Egg, whole 0.119000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.119000 1.000 1.000 

7000146000 70 Egg, white 0.119000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.119000 1.000 1.000 

7000147000 70 Egg, yolk 0.119000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.119000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.018480 1.000 1.000 ave. 1

 Full comment: ave. 1 in 10 yr, cranberry scenario

8602000000 86B Water, indirect, all sources 0.018480 1.000 1.000 ave. 1

 Full comment: ave. 1 in 10 yr, cranberry scenario

9500177000 O Grape, leaves 0.503000 1.000 1.000 
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 38 of 41

9500178000 O Grape, raisin 0.503000 2.700 1.000 

9500263000 O Peanut 0.003000 1.000 0.025 

9500264000 O Peanut, butter 0.003000 1.890 0.025 

9500265000 O Peanut, oil 0.003000 1.400 0.025 

9500275000 O Peppermint 3.870000 1.000 1.000 

9500276000 O Peppermint, oil 3.870000 0.028 1.000 

9500352000 O Spearmint 3.870000 1.000 1.000 

9500353000 O Spearmint, oil 3.870000 0.028 1.000 

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for INDOXACARB NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\iencarna\My Documents\DEEM Version 

3.16\Indoxacarb\INDOXACARB_CHRONIC.R08

 Adjustment factor #2 used.

Analysis Date 04-30-2013/16:31:57 Residue file dated: 04-30-2013/16:16:25

Reference dose (RfD, Chronic) = .02 mg/kg bw/day

COMMENT 1: EDWC 0.01848 ppm for chronic

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.001133 5.7%

Hispanic 0.000991 5.0%

Non-Hisp-White 0.001112 5.6%

Non-Hisp-Black 0.001346 6.7%

Non-Hisp-Other 0.001276 6.4%

Nursing Infants 0.000814 4.1%

Non-Nursing Infants 0.002200 11.0%

Female 13+ PREG 0.000951 4.8%

Children 1-6 0.001967 9.8%

Children 7-12 0.001034 5.2%

Male 13-19 0.000748 3.7%

Female 13-19/NP 0.000738 3.7%

Male 20+ 0.001014 5.1%

Female 20+/NP 0.001165 5.8%

Seniors 55+ 0.001149 5.7%

All Infants 0.001772 8.9%

Female 13-50 0.001038 5.2%

Children 1-2 0.002381 11.9%

Children 3-5 0.001818 9.1%

Children 6-12 0.001105 5.5%

Youth 13-19 0.000743 3.7%

Adults 20-49 0.001036 5.2%

Adults 50-99 0.001165 5.8%

Female 13-49 0.001037 5.2%

-------------------------------------------------------------------------------
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 39 of 41

Attachment 4: Screening Level Estimates of Agricultural Uses of Indoxacarb (067710), 

October 12, 2012, Reporting Years: 2004-2011

Percent Crop Treated

Crop Lbs. A.I. Avg. Max.

1 Alfalfa 10,000 <1 <2.5

2 Apples 2,000 5 10

3 Broccoli 5,000 50 70

4 Brussels Sprout* <500 NC NC

5 Cabbage 2,000 25 35

6 Cantaloupes <500 5 10

7 Cauliflower 1,000 40 60

8 Celery <500 5 5

9 Cherries <500 <1 <2.5

10 Cotton 10,000 <1 <2.5

11 Cucumbers <500 <1 <2.5

12 Grapes <500 <1 <2.5

13 Lettuce 4,000 10 40

14 Nectarines 1,000 15 15

15 Peaches <500 <2.5 <2.5

16 Peanuts 3,000 <2.5 10

17 Pears <500 <1 <2.5

18 Peppers 1,000 15 30

19 Plums/Prunes <500 <2.5 5

20 Potatoes 1,000 <1 <2.5

21 Pumpkins <500 <2.5 <2.5

22 Soybeans 4,000 <1 <2.5

23 Spinach <500 <2.5 5

24 Squash <500 <2.5 5

25 Sweet Corn 1,000 <2.5 10

26 Tomatoes 9,000 20 40

27 Watermelons <500 5 10

All numbers are rounded.

<500: indicates less than 500 pounds of active ingredient.

 <2.5: indicates less than 2.5 percent of crop is treated.

 <1: indicates less than 1 percent of crop is treated.

* California data only.
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 40 of 41

NC: not calculated, only pounds a.i. available. 

SLUA data sources include: 

USDA-NASS (United States Department of Agriculture's National Agricultural Statistics Service) 

Private Pesticide Market Research

California DPR (Department of Pesticide Regulation)

These results reflect amalgamated data developed by the Agency and are releasable to the public.
Indoxacarb Dietary Exposure Assessment DP Bar code: 408983

Page 41 of 41

Attachment #5: Highest/average residues of indoxacarb in feedstuff commodities6

1. Wet apple pomace (CC)1

Processing factor = 2.6x; Highest field trial residue adjusted for application rate = 0.74 ppm

Average residue in wet apple pomace = 1.9 ppm

2. Cotton undelinted seed (PC)1

Highest field trial residue adjusted for application rate = 1.3 ppm

3. Cotton gin byproducts (R)1

Highest field trial residue adjusted for application rate = 6.7 ppm

* a bridging study showed higher residues than these but were not considered because the plants were not 

allowed to dry before ginning; therefore, they had more leaves than normally and resulted in higher residues.

4. Sweet Corn stover (R)1

Highest field trial residue adjusted for application rate = 13.4 ppm

5. Sweet Corn forage (R)1

Highest field trial residue adjusted for application rate = 8.7 ppm

6. Peanut Hay (R)2

Highest / Average field trial residue = 18 ppm / 7.8 ppm

7. Alfalfa forage (R)3

Highest / Average field trial residue = 9.0 ppm / 4.8 ppm

8. Alfalfa hay (R)3

Highest / Average field trial residue = 39 ppm / 15 ppm

9. Soybean seed (PC)3

Average field trial = 0.088 ppm

10. Soybean hulls (R)3,4

Processing Factor4= 8.2x; Average field trial of soybean seed3= 0.088 ppm

Average residue in soybean hulls = 0.72 ppm

11. Cowpea, foliage (R)5

Highest / Average field trial residue = 32.1 ppm / 12.6 ppm

12. Cowpea, hay (R)5

Highest / Average field trial residue = 92 ppm / 36 ppm (Estimated from foliage data and % DM, * 86 / 30)

_____________________________________________________________________

1

 Sarah J. Levy; 19-JAN-2000; DP Barcodes: D244253. 

2

Sarah J. Levy; 7-JAN -2005; DP Barcode 301655.

3

Sarah J. Levy; 30-MAY-2002; DP Barcode: D276516. 

4 MRID 45384305; Devine, T.; 2000.

5

Ideliz Negron-Encarnacion; DP Barcode: D408982. 

6 Residue values in bold were used for dietary burden calculations to support the chronic dietary assessment.