STRUCTURE ACTIVITY TEAM REPORT 12/09/03

CASE NUMBER: P04-0141

RELATED CASES:

CONCLUSIONS/DISCUSSIONS

TYPE OF CONCERN: HEALTH ECOTOX

LEVEL OF CONCERN: 2 2

KEYWORDS: LUNG IRR-E,S,MM,L
AQUATOX

SUMMARY OF ASSESSMENT

FATE: Solid; ; Estimations for P-140 low MW274 LogKow = - 1.55(E)S = Disp.(ICB); H < 1.00E-8(E) MP (C) = 250(E); BP (C) > 400(E); VP @ 25C (mm) < 1.0E-6(E) LogKoc = 1.28(E); LogBCF = 0.50(E); POTW removal (%) = 139/40 : 90 via biodeg; P-139 OECD91.6%/28d; OECD 301E(Mod Screening): 71.5%/28d; P140 OECD 301B(Mod Sturm CO2 Ev): 77.5%/28d RB; 141 : 50 via sorption & biodeg; P-141 BOD5/COD=58.5%; OECD 301E(Mod Screening): 38.9%/28d NRB; OECD: 60%/28d; River Die Away Test (5d/10d/15d/20d): 35%/59%/79%/90%; OECD 301D(Closed Bottle) 2 & 10mg/L: 90.1 & 82.2%/28d. Time for complete ultimate aerobic biodeg = wk-mo
PBT Potential: P1B1T1 Sorption to soils/sediments = low *CEB FATE: Migration to ground water = slow - moderate

HEALTH: Absorption is nil from the skin, poor from the GI tract, and moderate from the lung (analog). Concern for surfactant effects on the lung; and irritation to all tissues based on
submitted test data.

*CEB HEALTH: Moderate concern (Dermal, inhalation); XB: NO testing

Test data: mouse oral LD

50 = 7.5 mL/kg (20%ai); slight skin irritation in rabbits (16% ai); severe eye irritation in rabbits (pH 7, 10% ai); moderate eye irritation in rabbits (16% ai)

ECOTOX: Predicted (P) and measured (M) toxicity values in mg/L (ppm) FOR THE LEAST TOXIC PRODUCT THAT CAN BE MAKE UNDER THE CAS NAME (92% WITH WEIGHT AVERAGE are:
fish 96-h LC50 = 350.0 P daphnid 48-h LC50 = 350.0 P green algal 96-h EC50 = 350.0 P
fish chronic value = 40.0 P daphnid ChV = 40.0 P algal ChV = 90.0 PPredictions are based on SAR-nearest analog method for amphoteric surfactants-; SAR chemical class = surfactant-amphoteric; MW428; pH7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as; and TOC <2.0 mg/L; low concern for toxicity

assessment factor = 10.0 concern concentration = 1.0 mg/L (ppm)

Predicted (P) and measured (M) toxicity values in mg/L (ppm) FOR
THE MOST TOXIC PRODUCT THAT CAN BE MAKE UNDER THE CAS NAME (2

WITH WEIGHT AVERAGE are:
fish 96-h LC50 = 0.590 P daphnid 48-h LC50 = 0.590 P green algal 96-h EC50 = 0.590 P
fish chronic value = 0.060 P daphnid ChV = 0.060 P algal ChV = 0.150 P Predictions are based on SAR-nearest analog method for amphoteric surfactants-; SAR chemical class = surfactant-amphoteric-; MW504; pH7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as; and TOC <2.0 mg/L; high concern for toxicity

assessment factor = 10.0 concern concentration = 0.006 mg/L (ppm)

Submitted test data for a product with unknown composition: fish (FHM) 96-h LC50 = 2.1 M S,N H270 daphnid 48-h LC50 = 4.0 M S,N fish ChV = 0.200 P FHM/ACR10 daphnid ChV = 0.400 P D48/ACR10 The toxicity of this product is intermediate between the worst case product the least toxic product.

*CEB ECOTOX: All releases to water; risk assessment needed for both CCs: 6 ppb and 1000 ppb; and XB: Testing desired.

SAT Co-chair: Leonard Keifer 564-8916