Loan and Security Agreement



 Exhibit 10.12 
 [*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions. 
  
  
  

 
 diaDexus, Inc. 

LOAN AND SECURITY AGREEMENT 







 This LOAN AND SECURITY AGREEMENT (this “Agreement”) is entered into as of September 23, 2011,
by and between Comerica Bank (“Bank”) and diaDexus, Inc. (“Borrower”). 
 RECITALS 

Borrower wishes to obtain credit from time to time from Bank, and Bank desires to extend credit to Borrower. This Agreement sets forth the terms on which
Bank will advance credit to Borrower, and Borrower will repay the amounts owing to Bank. 
 AGREEMENT 

The parties agree as follows: 

1.    DEFINITIONS AND CONSTRUCTION. 
 1.1     Definitions. As used in this Agreement, all capitalized terms shall have the definitions set forth on Exhibit A. Any term used in the Code and not defined herein shall
have the meaning given to the term in the Code. 
 1.2     Accounting Terms. Any accounting term not
specifically defined on Exhibit A shall be construed in accordance with GAAP and all calculations shall be made in accordance with GAAP. The term “financial statements” shall include the accompanying notes and schedules. 

2.     LOAN AND TERMS OF PAYMENT. 
 2.1     Credit Extensions. 

(a)     Promise to Pay. Borrower promises to pay to Bank, in lawful money of the United States of America, the
aggregate unpaid principal amount of all Credit Extensions made by Bank to Borrower, together with interest on the unpaid principal amount of such Credit Extensions at rates in accordance with the terms hereof. 

(b)    Growth Capital Advances. 
 (i)     Subject to and upon the terms and conditions of this Agreement, Bank agrees to make one (1) Growth Capital Advance to Borrower, on the Closing Date. The aggregate
outstanding amount of Growth Capital Advance shall not exceed the Growth Capital Line. 
 (ii)     Interest
shall accrue from the date of the Growth Capital Advance at the rate specified in Section 2.2(a), and shall be payable in accordance with Section 2.2(c). Any part of the Growth Capital Advance that is outstanding on Growth Capital Interest
Only End Date shall be payable in thirty six (36) equal monthly installments of principal, plus all accrued interest, beginning on the 23rd day of the first month after the Growth Capital Interest Only End Date, and continuing on the same day
of each month thereafter through the Growth Capital Maturity Date, when all Obligations under this Agreement shall be due and payable in full. The Growth Capital Advance, once repaid, may not be reborrowed. Borrower may prepay the Growth Capital
Advance only in accordance with Sections 2.1(b)(iv) and (v) of this Agreement. 
 (iii)     Borrower
shall provide Bank a completed advance request form substantially in the form of Exhibit C attached hereto (which notice shall be irrevocable) by facsimile transmission to be received no later than 3:00 p.m. Pacific time three
(3) Business Days before the Closing Date. The notice shall be signed by a Responsible Officer or its designee and include a copy of the invoice for any Equipment to be financed. Bank shall be entitled to rely on any facsimile or telephonic
notice given by a person who Bank reasonably believes to be a Responsible Officer or a designee thereof, and Borrower shall indemnify and hold Bank harmless for any damages or loss suffered by Bank as a result of such reliance. 

  

			
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 (iv)     If the Growth Capital Advance is accelerated following the
occurrence of an Event of Default, Borrower shall immediately pay to Bank an amount equal to the sum of: (i) all outstanding principal of the Growth Capital Advance plus accrued but unpaid interest thereon through the prepayment date,
(ii) the Final Payment, (iii) the Prepayment Fee (if then due hereunder), plus (iv) all other sums, that shall have become due and payable, including Bank Expenses and interest at the default rate with respect to any past due amounts.
Notwithstanding (but without duplication with) the foregoing, on the Growth Capital Maturity Date, if the Final Payment had not previously been paid in full in connection with the prepayment of the Growth Capital Advance in full, Borrower shall pay
to Bank, the Final Payment in respect of the Growth Capital Advance. 
 (v)     Borrower shall have the
option to prepay all, but not less than all, of the Growth Capital Advance advanced by Bank under this Agreement, provided Borrower (i) provides written notice to Bank of its election to prepay the Growth Capital Advance at least thirty
(30) days prior to such prepayment, and (ii) pays to Bank on the date of such prepayment an amount equal to the sum of (A) all outstanding principal of the Growth Capital Advance plus accrued but unpaid interest thereon through the
prepayment date, (B) the Final Payment, (C) the Prepayment Fee (if then due hereunder), plus (D) all other sums, that shall have become due and payable but have not been paid, including Bank Expenses, if any, and interest at the
default rate with respect to any past due amounts. 
 (vi)     Borrower hereby waives any rights under
section 2954.10 of the California Civil Code or successor statute, with respect to any prepayment (or similar) costs, fees and or penalties due or to become due and or payable hereunder. 

2.2     Interest Rates, Payments, and Calculations. 

(a)     Interest Rate. Except as set forth in Section 2.2(b), the Growth Capital Advances shall bear
interest, on the outstanding daily balance thereof, at a fixed per annum rate equal to five and one quarter percent (5.25%). 

(b)    Late Fee; Default Rate. If any payment is not made within 10 days after the date such payment is due,
Borrower shall pay Bank a late fee equal to the lesser of (i) five percent (5%) of the amount of such unpaid amount or (ii) the maximum amount permitted to be charged under applicable law. All Obligations shall bear interest, from and
after the occurrence and during the continuance of an Event of Default, at a rate equal to five (5) percentage points above the interest rate applicable immediately prior to the occurrence of the Event of Default. 

(c)     Payments. Interest hereunder shall be due and payable on the 23rd calendar day of each month during
the term hereof. Bank shall, at its option, charge such interest, all Bank Expenses, and all Periodic Payments against any of Borrower’s deposit accounts. Any interest not paid when due shall be compounded by becoming a part of the Obligations,
and such interest shall thereafter accrue interest at the rate then applicable hereunder. 
 (d)    
Computation. All interest chargeable under the Loan Documents shall be computed on the basis of a three hundred sixty (360) day year for the actual number of days elapsed. 

2.3     Crediting Payments. Prior to the occurrence of an Event of Default, Bank shall credit a wire transfer
of funds, check or other item of payment to such deposit account or Obligation as Borrower specifies. After the occurrence of an Event of Default, Bank shall have the right, in its sole discretion, to immediately apply any wire transfer of funds,
check, or other item of payment Bank may receive to conditionally reduce Obligations, but such applications of funds shall not be considered a payment on account unless such payment is of immediately available federal funds or unless and until such
check or other item of payment is honored when presented for payment. Notwithstanding anything to the contrary contained herein, any wire transfer or payment received by Bank after 12:00 noon Pacific time shall be deemed to have been received by
Bank as of the opening of business on the immediately following Business Day. Whenever any payment to Bank under the Loan Documents would otherwise be due (except by reason of acceleration) on a date that is not a Business Day, such payment shall
instead be due on the next Business Day, and additional fees or interest, as the case may be, shall accrue and be payable for the period of such extension. 

  

			
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 2.4     Fees. Borrower shall pay to Bank the following:

 (a)     Facility Fee. On the Closing Date, a fee equal to Twenty Five Thousand Dollars ($25,000),
which shall be nonrefundable (and the commitment fee previously paid by Borrower, receipt of which hereby is acknowledged by Bank, shall be credited in full against such fee); 
 (b)     Prepayment Fee. The Prepayment Fee, if and when due; 
 (c)     Final Payment. The Final Payment, when due; and 

(d)     Bank Expenses. On the Closing Date, all Bank Expenses incurred through the Closing Date, and, after
the Closing Date, all Bank Expenses, as and when they become due. 
 2.5     Term. This Agreement
shall become effective on the Closing Date and, subject to Section 13.8, shall continue in full force and effect for so long as any Obligations remain outstanding or Bank has any obligation to make Credit Extensions under this Agreement.
Notwithstanding the foregoing, Bank shall have the right to terminate its obligation to make Credit Extensions under this Agreement immediately and without notice upon the occurrence and during the continuance of an Event of Default. 

3.     CONDITIONS OF LOANS. 
 3.1     Conditions Precedent to Initial Credit Extension. The obligation of Bank to make the initial Credit Extension is subject to the condition precedent that Bank shall have
received, in form and substance satisfactory to Bank, the following: 
 (a)     this Agreement, duly
executed by Borrower; 
 (b)     an officer’s certificate of Borrower with respect to incumbency and
resolutions authorizing the execution and delivery of this Agreement; 
 (c)     UCC National Form Financing
Statement; 
 (d)     agreement to furnish insurance; 

(e)     payment of the Bank Expenses then due specified in Section 2.4; 

(f)     current SOS Reports indicating that except for Permitted Liens, there are no other security interests or
Liens of record in the Collateral; 
 (g)     current financial statements, including audited statements for
Borrower’s most recently ended fiscal year, together with an unqualified opinion, company prepared consolidated balance sheets and income statements for the most recently ended month in accordance with Section 6.2, and such other updated
financial information as Bank may reasonably request; 
 (h)     current Compliance Certificate in
accordance with Section 6.2; 
 (i)     a Warrant in form and substance satisfactory to Bank;

 (j)     a Collateral Information Certificate; 

(k)    subject to Section 6.6, securities and/or deposit account control agreements with respect to any accounts
permitted hereunder to be maintained outside Bank; 
 (l)     an Automatic Debit Authorization; and


  

			
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 (m)     such other documents or certificates, and completion of such
other matters, as Bank may reasonably deem necessary or appropriate. 
 3.2     Conditions Precedent to
all Credit Extensions. The obligation of Bank to make each Credit Extension, including the initial Credit Extension, is further subject to the following conditions: the representations and warranties contained in Article 5 shall be true and
correct in all material respects on and as of the date of such Payment/Advance Form and on the effective date of each Credit Extension as though made at and as of each such date, and no Event of Default shall have occurred and be continuing, or
would exist after giving effect to such Credit Extension (provided, however, that those representations and warranties expressly referring to another date shall be true, correct and complete in all material respects as of such date). The making of
each Credit Extension shall be deemed to be a representation and warranty by Borrower on the date of such Credit Extension as to the accuracy of the facts referred to in this Section 3.2. 

4.     CREATION OF SECURITY INTEREST. 
 4.1     Grant of Security Interest. Borrower grants and pledges to Bank a continuing security interest in the Collateral to secure prompt repayment of any and all Obligations
and to secure prompt performance by Borrower of each of its covenants and duties under the Loan Documents. Except as set forth in the Schedule, such security interest constitutes a valid, first priority security interest in the presently existing
Collateral, and will constitute a valid, first priority security interest in later-acquired Collateral. Borrower also hereby agrees not to sell, transfer, assign, mortgage, pledge, lease, grant a security interest in, or encumber any of its
Intellectual Property, except in connection with Permitted Liens and Permitted Transfers. Notwithstanding any termination of this Agreement, Bank’s Lien on the Collateral shall remain in effect for so long as any Obligations are outstanding.

 4.2     Perfection of Security Interest. Borrower authorizes Bank to file at any time financing
statements, continuation statements, and amendments thereto that (i) either specifically describe the Collateral or describe the Collateral as all assets of Borrower of the kind pledged hereunder, and (ii) contain any other information
required by the Code for the sufficiency of filing office acceptance of any financing statement, continuation statement, or amendment, including whether Borrower is an organization, the type of organization and any organizational identification
number issued to Borrower, if applicable. Any such financing statements may be filed by Bank at any time in any jurisdiction whether or not Revised Article 9 of the Code is then in effect in that jurisdiction. Borrower shall from time to time
endorse and deliver to Bank, at the request of Bank, all Negotiable Collateral and other documents that Bank may reasonably request, in form satisfactory to Bank, to perfect and continue perfection of Bank’s security interests in the Collateral
and in order to fully consummate all of the transactions contemplated under the Loan Documents. Borrower shall have possession of the Collateral, except where expressly otherwise provided in this Agreement or where Bank chooses to perfect its
security interest by possession in addition to the filing of a financing statement. Where Collateral is in possession of a third party bailee, Borrower shall take such steps as Bank reasonably requests for Bank to (i) obtain an acknowledgment,
in form and substance satisfactory to Bank, of the bailee that the bailee holds such Collateral for the benefit of Bank, and (ii) obtain “control” of any Collateral consisting of investment property, deposit accounts, letter-of-credit
rights or electronic chattel paper (as such items and the term “control” are defined in Revised Article 9 of the Code) by causing the securities intermediary or depositary institution or issuing bank to execute a control agreement in form
and substance satisfactory to Bank. Borrower will not create any chattel paper without placing a legend on the chattel paper acceptable to Bank indicating that Bank has a security interest in the chattel paper. Borrower from time to time may deposit
with Bank specific cash collateral to secure specific Obligations; Borrower authorizes Bank to hold such specific balances in pledge and to decline to honor any drafts thereon or any request by Borrower or any other Person to pay or otherwise
transfer any part of such balances for so long as the specific Obligations are outstanding. 
 4.3    
Right to Inspect. Bank (through any of its officers, employees, or agents) shall have the right, upon reasonable prior notice, from time to time during Borrower’s usual business hours but no more than twice a year (unless an Event of
Default has occurred and is continuing), to inspect Borrower’s Books and to make copies thereof and to check, test, and appraise the Collateral in order to verify Borrower’s financial condition or the amount, condition of, or any other
matter relating to, the Collateral. 

  

			
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 5.     REPRESENTATIONS AND WARRANTIES. 

Borrower represents and warrants as follows: 
 5.1     Due Organization and Qualification. Borrower and each Subsidiary is an entity duly existing under the laws of the jurisdiction in which it is organized and qualified and
licensed to do business in any state in which the conduct of its business or its ownership of property requires that it be so qualified, except where the failure to do so could not reasonably be expected to cause a Material Adverse Effect.

 5.2     Due Authorization; No Conflict. The execution, delivery, and performance of the Loan
Documents are within Borrower’s powers, have been duly authorized, and are not in conflict with nor constitute a breach of any provision contained in Borrower’s organizational documents, nor will they constitute an event of default under
any material agreement by which Borrower is bound. Borrower is not in default under any agreement by which it is bound, except to the extent such default would not reasonably be expected to cause a Material Adverse Effect. 

5.3     Collateral. Borrower has rights in or the power to transfer the Collateral, and its title to the
Collateral is free and clear of Liens, adverse claims, and restrictions on transfer or pledge except for Permitted Liens. All Collateral (other than (x) movable items of personal property (such as laptop computers) having an aggregate book
value not to exceed Fifty Thousand Dollars ($50,000) at any time and (y) laboratory Equipment having an aggregate book value not to exceed Two Hundred Thousand Dollars ($200,000) at any single location) is located solely in the Collateral
States. All Inventory is in all material respects of good and merchantable quality, free from all material defects, except for Inventory for which adequate reserves have been made. Except as set forth in the Schedule, none of the Collateral is
maintained or invested with a Person other than Bank or Bank’s Affiliates. 
 5.4     Intellectual
Property. Borrower is the sole owner of Borrower’s owned Intellectual Property, except for licenses granted by Borrower to its customers in the ordinary course of business. To the best of Borrower’s knowledge, each of the Copyrights,
Trademarks and Patents is valid and enforceable, and no part of the Intellectual Property has been judged invalid or unenforceable, in whole or in part, and no claim has been made to Borrower that any part of the Intellectual Property violates the
rights of any third party except to the extent such claim could not reasonably be expected to cause a Material Adverse Effect. 

5.5     Name; Location of Chief Executive Office. Except as disclosed in the Schedule, Borrower has not done
business under any name other than that specified on the signature page hereof, and its exact legal name is as set forth in the first paragraph of this Agreement. The chief executive office of Borrower is located in the Chief Executive Office State
at the address indicated in Section 10 hereof. 
 5.6     Actions, Suits, Litigation, or
Proceedings. Except as set forth in the Schedule, there are no actions, suits, litigation or proceedings, at law or in equity, pending by or against Borrower or any Subsidiary before any court, administrative agency, or arbitrator in which a
likely adverse decision could reasonably be expected to have a Material Adverse Effect. 
 5.7    No
Material Adverse Change in Financial Statements. All consolidated and consolidating financial statements related to Borrower and any Subsidiary that are delivered by Borrower to Bank fairly present in all material respects Borrower’s
consolidated and consolidating financial condition as of the date thereof and Borrower’s consolidated and consolidating results of operations for the period then ended. There has not been a material adverse change in the consolidated or in the
consolidating financial condition of Borrower since the date of the most recent of such financial statements submitted to Bank. 

5.8     Solvency, Payment of Debts. Borrower is able to pay its debts (including trade debts) as they mature;
the fair saleable value of Borrower’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; and Borrower is not left with unreasonably small capital after the transactions contemplated by this Agreement.


  

			
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 5.9     Compliance with Laws and Regulations. Borrower and each
Subsidiary have met the minimum funding requirements of ERISA with respect to any employee benefit plans subject to ERISA. No event has occurred resulting from Borrower’s failure to comply with ERISA that is reasonably likely to result in
Borrower’s incurring any liability that could reasonably be expected to have a Material Adverse Effect. Borrower is not an “investment company” or a company “controlled” by an “investment company” within the
meaning of the Investment Company Act of 1940. Borrower is not engaged principally, or as one of the important activities, in the business of extending credit for the purpose of purchasing or carrying margin stock (within the meaning of Regulations
T and U of the Board of Governors of the Federal Reserve System). Borrower has complied in all material respects with all the provisions of the Federal Fair Labor Standards Act. Borrower is in compliance with all environmental laws, regulations and
ordinances except where the failure to comply is not reasonably likely to have a Material Adverse Effect. Borrower has not violated any statutes, laws, ordinances or rules applicable to it, the violation of which could reasonably be expected to have
a Material Adverse Effect. Borrower and each Subsidiary have filed or caused to be filed all tax returns required to be filed, and have paid, or have made adequate provision for the payment of, all taxes reflected therein except those being
contested in good faith with adequate reserves under GAAP or where the failure to file such returns or pay such taxes could not reasonably be expected to have a Material Adverse Effect. 

5.10     Subsidiaries. Borrower does not own any stock, partnership interest or other equity securities of any
Person, except for Permitted Investments. 
 5.11     Government Consents. Borrower and each
Subsidiary have obtained all consents, approvals and authorizations of, made all declarations or filings with, and given all notices to, all governmental authorities that are necessary for the continued operation of Borrower’s business as
currently conducted, except where the failure to do so would not reasonably be expected to cause a Material Adverse Effect. 

5.12     Inbound Licenses. Except as disclosed on the Schedule, Borrower is not a party to, nor is bound by,
any inbound license or other agreement, the failure, breach, or termination of which could reasonably be expected to cause a Material Adverse Effect, or that prohibits or otherwise restricts Borrower from granting a security interest, to the extent
contemplated by this Agreement, in Borrower’s interest in such license or agreement or any other property. 

5.13     Full Disclosure. No representation, warranty or other statement made by Borrower in any certificate or
written statement furnished to Bank taken together with all such certificates and written statements furnished to Bank contains any untrue statement of a material fact or omits to state a material fact necessary in order to make the statements
contained in such certificates or statements not misleading, it being recognized by Bank that the projections and forecasts provided by Borrower in good faith and based upon reasonable assumptions are not to be viewed as facts and that actual
results during the period or periods covered by any such projections and forecasts may differ from the projected or forecasted results. 
 6.     AFFIRMATIVE COVENANTS. 
 Borrower covenants that,
until payment in full of all outstanding Obligations, and for so long as Bank may have any commitment to make a Credit Extension hereunder, Borrower shall do all of the following: 

6.1     Good Standing and Government Compliance. Borrower shall maintain its and each of its Subsidiaries’
organizational existence and good standing in the Borrower State, shall maintain qualification and good standing in each other jurisdiction in which the failure to so qualify could reasonably be expected to have a Material Adverse Effect, and shall
furnish to Bank the organizational identification number issued to Borrower by the authorities of the jurisdiction in which Borrower is organized, if applicable. Borrower shall meet, and shall cause each Subsidiary to meet, the minimum funding
requirements of ERISA with respect to any employee benefit plans subject to ERISA. Borrower shall comply in all material respects with all applicable Environmental Laws, and maintain all material permits, licenses and approvals required thereunder
where the failure to do so could reasonably be expected to have a Material Adverse Effect. Borrower shall comply, and shall cause each Subsidiary to comply, with all statutes, laws, ordinances and government rules and regulations to which it is
subject, and shall maintain, and shall cause each of its Subsidiaries to maintain, in force all licenses, approvals and agreements, the loss of which or failure to comply with which would reasonably be expected to have a Material Adverse Effect.


  

			
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 6.2     Financial Statements, Reports, Certificates. Borrower
shall deliver to Bank: (i) as soon as available, but in any event within (x) thirty (30) days after the end of each calendar month, and (y) forty-five (45) days after the end of each calendar quarter, a company prepared
consolidated (and, if and when Borrower creates or acquires any Subsidiaries, consolidating) balance sheet and income statement covering Borrower’s operations during such period, in a form reasonably acceptable to Bank and certified by a
Responsible Officer; (ii) as soon as available, but in any event within one hundred twenty (120) days after the end of Borrower’s fiscal year, audited consolidated (and, if and when Borrower creates or acquires any Subsidiaries,
consolidating) financial statements of Borrower prepared in accordance with GAAP, consistently applied, together with an opinion which is unqualified (or qualified only based upon a lack of twelve (12) months’ cash) or otherwise consented
to in writing by Bank on such financial statements of PriceWaterhouse Coopers or such other independent certified public accounting firm reasonably acceptable to Bank; (iii) if applicable, copies of all statements, reports and notices sent or
made available generally by Borrower to its security holders or to any holders of Subordinated Debt and all reports on Forms 10-K and 10-Q filed with the Securities and Exchange Commission; (iv) promptly upon receipt of notice thereof, a report
of any legal actions pending or threatened against Borrower or any Subsidiary that could result in damages or costs to Borrower or any Subsidiary of One Hundred Thousand Dollars ($100,000) or more; (v) promptly upon receipt in final form, each
management letter prepared by Borrower’s independent certified public accounting firm regarding Borrower’s management control systems; (vi) as soon as available, but in any event not later than January 31 of each calendar year,
Borrower’s financial and business projections and budget for such year, with evidence of approval thereof by Borrower’s board of directors; and (vii) such budgets, sales projections, operating plans or other financial information
generally prepared by Borrower in the ordinary course of business as Bank may reasonably request from time to time. 

(a)     Within thirty (30) days after the last day of each month, Borrower shall deliver to Bank a Compliance
Certificate certified as of the last day of the applicable month and signed by a Responsible Officer in substantially the form of Exhibit D hereto. 
 (b)     Immediately upon becoming aware of the occurrence or existence of an Event of Default hereunder, a written statement of a Responsible Officer setting forth details of the Event
of Default, and the action which Borrower has taken or proposes to take with respect thereto. 
 (c)    
Bank shall have a right from time to time hereafter to audit Borrower’s Accounts and appraise Collateral at Borrower’s expense, provided that such audits will be conducted no more often than every six (6) months unless an Event of
Default has occurred and is continuing. 
 Borrower may deliver to Bank on an electronic basis any certificates, reports or
information required pursuant to this Section 6.2, and Bank shall be entitled to rely on the information contained in the electronic files, provided that Bank in good faith believes that the files were delivered by a Responsible Officer. If
Borrower delivers this information electronically, it shall also deliver to Bank by U.S. Mail, reputable overnight courier service, hand delivery, facsimile or .pdf file within five (5) Business Days of submission of the unsigned electronic
copy the certification of monthly financial statements, and the Compliance Certificate, each bearing the physical signature of the Responsible Officer. 
 6.3     Inventory; Returns. Borrower shall keep all Inventory in good and merchantable condition, free from all material defects except for Inventory for which adequate reserves
have been made. Returns and allowances, if any, as between Borrower and its account debtors shall be on the same basis and in accordance with the usual customary practices of Borrower, as they exist on the Closing Date. Borrower shall promptly
notify Bank of all returns and recoveries and of all disputes and claims involving more than One Hundred Thousand Dollars ($100,000). 
 6.4     Taxes. Borrower shall make, and cause each Subsidiary to make, due and timely payment or deposit of all material federal, state, and local taxes, assessments, or
contributions required of it by law, including, but not limited to, those laws concerning income taxes, F.I.C.A., F.U.T.A. and state disability, and will execute and deliver to Bank, on demand, proof satisfactory to Bank indicating that Borrower or
a Subsidiary has made such payments or deposits and any appropriate certificates attesting to the payment or deposit thereof; provided that Borrower or a Subsidiary need not make any payment if the amount or validity of such payment is


  

			
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contested in good faith by appropriate proceedings and is reserved against (to the extent required by GAAP) by Borrower. 
 6.5     Insurance. 
 (a)    
Borrower, at its expense, shall keep the Collateral insured against loss or damage by fire, theft, explosion, sprinklers, and all other hazards and risks, and in such amounts, as ordinarily insured against by other owners in similar businesses
conducted in the locations where Borrower’s business is conducted on the date hereof. Borrower shall also maintain liability and other insurance in amounts and of a type that are customary to businesses similar to Borrower’s. 

(b)     All such policies of insurance shall be in such form, with such companies, and in such amounts as reasonably
satisfactory to Bank. All policies of property insurance shall contain a lender’s loss payable endorsement, in a form satisfactory to Bank, showing Bank as an additional loss payee, and all liability insurance policies shall show Bank as an
additional insured and specify that the insurer must give at least twenty (20) days notice to Bank before canceling its policy for any reason. Upon Bank’s request, Borrower shall deliver to Bank certified copies of the policies of
insurance and evidence of all premium payments. If no Event of Default has occurred and is continuing, proceeds payable under any casualty policy will, at Borrower’s option, be payable to Borrower to replace the property subject to the claim,
provided that any such replacement property shall be deemed Collateral in which Bank has been granted a first priority security interest. If an Event of Default has occurred and is continuing, all proceeds payable under any such policy shall, at
Bank’s option, be payable to Bank to be applied on account of the Obligations. 
 6.6
    Accounts. Borrower shall maintain its primary depository and operating accounts with Bank and at least eighty percent (80%) of the dollar value of Borrower’s investment accounts with Bank or Bank’s
Affiliates; provided that all accounts permitted hereunder to be maintained outside Bank shall, within thirty (30) days of the Closing Date, be (i) closed and the balances therein transferred to accounts with Bank or Bank’s
Affiliates, or (ii) subject to control agreements in form and content reasonably acceptable to Bank. Notwithstanding the foregoing, with respect to Borrower’s account with Silicon Valley Bank, ending in 6022 (the “SVB Account”),
Borrower shall not be required to (x) close the SVB Account before June 30, 2012, or (y) deliver to Bank a control agreement with respect thereto. 
 6.7     Financial Covenants. Borrower shall at all times maintain the following financial ratios and covenants: 

(a)     Performance to Plan. Revenues shall be at least eighty percent (80%) of the monthly projections
that have been approved by Borrower’s Board of Directors and attached as Annex I to the Schedule hereto, calculated on a trailing three (3) month basis. Borrower shall deliver to Bank updated projections approved by Borrower’s Board
of Directors for the next fiscal year not more than thirty (30) days following the end of Borrower’s current fiscal year. 
 6.8     Registration of Intellectual Property Rights. 

(a)     Borrower shall register or cause to be registered on an expedited basis (to the extent not already
registered) with the United States Patent and Trademark Office or the United States Copyright Office, as the case may be, those registrable intellectual property rights now owned or hereafter developed or acquired by Borrower, to the extent that
Borrower, in its reasonable business judgment, deems it appropriate to so protect such intellectual property rights. 

(b)     Borrower shall give Bank prompt written notice of any applications or registrations of intellectual property
rights filed with the United States Patent and Trademark Office and United States Copyright Office, including the date of such filing and the registration or application numbers, if any. 

(c)     Borrower shall give Bank prompt written notice of the filing of any applications or registrations with the
United States Copyright Office, including the title of such intellectual property rights to be 

  

			
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registered, as such title will appear on such applications or registrations, and the date such applications or registrations will be filed. 

(d)     Borrower shall use commercially reasonable efforts to (i) protect, defend and maintain the validity and
enforceability of the Trademarks, Patents, Copyrights, and trade secrets, (ii) detect infringements of the Trademarks, Patents and Copyrights and promptly advise Bank in writing of material infringements detected and (iii) not allow any
material Trademarks, Patents or Copyrights to be abandoned, forfeited or dedicated to the public without the written consent of Bank, which shall not be unreasonably withheld. 
 6.9     Consent of Inbound Licensors. Prior to entering into or becoming bound by any inbound license or agreement (other than over-the-counter software that is commercially
available to the public), the failure, breach, or termination of which could reasonably be expected to cause a Material Adverse Effect, Borrower shall in good faith take commercially reasonable actions to obtain the consent of, or waiver by, any
person whose consent or waiver is necessary for (A) Borrower’s interest in such licenses or contract rights to be deemed Collateral and for Bank to have a security interest in it that might otherwise be restricted by the terms of the
applicable license or agreement, whether now existing or entered into in the future, and (B) Bank to have the ability in the event of a liquidation of any Collateral to dispose of such Collateral in accordance with Bank’s rights and
remedies under this Agreement and the other Loan Documents, provided, however, that the failure to obtain any such consent or waiver shall not constitute a default under this Agreement. 

6.10     Creation/Acquisition of Subsidiaries. In the event Borrower or any Subsidiary creates or acquires any
Subsidiary, Borrower and such Subsidiary shall promptly notify Bank of the creation or acquisition of such new Subsidiary and take all such action as may be reasonably required by Bank to cause each such domestic Subsidiary to guarantee the
Obligations of Borrower under the Loan Documents and grant a continuing pledge and security interest in and to the collateral of such Subsidiary (substantially as described on Exhibit B hereto), and Borrower shall grant and pledge to Bank a
perfected security interest in the stock, units or other evidence of ownership of each Subsidiary (whether foreign or domestic). 

6.11     Further Assurances. At any time and from time to time Borrower shall execute and deliver such further
instruments and take such further action as may reasonably be requested by Bank to effect the purposes of this Agreement. 

7.    NEGATIVE COVENANTS. 
 Borrower covenants and agrees that, so long as any credit hereunder shall be available and until the outstanding Obligations are paid in full or for so long as Bank may have any commitment to make any
Credit Extensions, Borrower will not do any of the following without Bank’s prior written consent, which shall not be unreasonably withheld: 
 7.1     Dispositions. Convey, sell, lease, license, transfer or otherwise dispose of (collectively, to “Transfer”), or permit any of its Subsidiaries to Transfer, all
or any part of its business or property, or subject to Section 6.6 of the Agreement, move cash balances on deposit with Bank to accounts opened at another financial institution, other than Permitted Transfers. 

7.2     Change in Name, Location, Executive Office, or Executive Management; Change in Business; Change in Fiscal
Year. Change its name or the Borrower State or relocate its chief executive office without thirty (30) days prior written notification to Bank; Borrower’s chief executive officer or chief financial officer shall cease to be actively
engaged in the management of Borrower unless a replacement for such officer is approved by Borrower’s Board of Directors and engaged by Borrower within ninety (90) days of such change; engage in any business, or permit any of its
Subsidiaries to engage in any business, other than or reasonably related or incidental to the businesses currently engaged in by Borrower; change its fiscal year end. 
 7.3     Mergers or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with or into any other business organization (other than
mergers or consolidations of a Subsidiary into another Subsidiary or into Borrower), or acquire, or permit any of its Subsidiaries to acquire, all or 

  

			
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 substantially all of the capital stock or property of another Person, or enter into any agreement to do any
of the same, except where (i) such transactions do not in the aggregate exceed One Hundred Thousand Dollars ($100,000) during any fiscal year, (ii) no Event of Default has occurred, is continuing or would exist after giving effect to such
transactions, (iii) such transactions do not result in a Change in Control, and (iv) Borrower is the surviving entity. 
 7.4    Indebtedness. Create, incur, assume, guarantee or be or remain liable with respect to any Indebtedness, or permit any Subsidiary so to do, other than Permitted
Indebtedness, or prepay any Indebtedness or take any actions which impose on Borrower an obligation to prepay any Indebtedness, except Indebtedness to Bank. 
 7.5    Encumbrances. Create, incur, assume or allow any Lien with respect to any of its property, or assign or otherwise convey any right to receive income, including the sale
of any Accounts, or permit any of its Subsidiaries so to do, except for Permitted Liens, or covenant to any other Person that Borrower in the future will refrain from creating, incurring, assuming or allowing any Lien with respect to any of
Borrower’s property. 
 7.6    Distributions. Pay any dividends or make any other distribution
or payment on account of or in redemption, retirement or purchase of any capital stock, except that Borrower may (i) repurchase the stock of former employees pursuant to stock repurchase agreements as long as an Event of Default does not exist
prior to such repurchase or would not exist after giving effect to such repurchase, and (ii) repurchase the stock of former employees pursuant to stock repurchase agreements by the cancellation of indebtedness owed by such former employees to
Borrower regardless of whether an Event of Default exists. 
 7.7    Investments. Directly or
indirectly acquire or own, or make any Investment in or to any Person, or permit any of its Subsidiaries to do so, other than Permitted Investments, or maintain or invest any of its property with a Person other than Bank or Bank’s Affiliates or
permit any Subsidiary to do so unless such Person has entered into a control agreement with Bank, in form and substance satisfactory to Bank, or suffer or permit any Subsidiary to be a party to, or be bound by, an agreement that restricts such
Subsidiary from paying dividends or otherwise distributing property to Borrower. Further, Borrower shall not enter into any license or agreement with any Prohibited Territory or with any Person organized under or doing business in a Prohibited
Territory. 
 7.8    Transactions with Affiliates. Directly or indirectly enter into or permit to
exist any material transaction with any Affiliate of Borrower except for transactions that are in the ordinary course of Borrower’s business, upon fair and reasonable terms that are no less favorable to Borrower than would be obtained in an
arm’s length transaction with a non-affiliated Person. 
 7.9    Subordinated Debt. Make any
payment in respect of any Subordinated Debt, or permit any of its Subsidiaries to make any such payment, except in compliance with the terms of such Subordinated Debt and the terms of the subordination agreement relating to such Subordinated Debt,
or amend any provision of any document evidencing such Subordinated Debt, except in compliance with the terms of the subordination agreement relating to such Subordinated Debt, or amend any provision affecting Bank’s rights contained in any
documentation relating to the Subordinated Debt without Bank’s prior written consent. 

7.10    Inventory and Equipment. Store the Inventory or the Equipment (other than (x) movable items of
personal property (such as laptop computers) having an aggregate book value not to exceed Fifty Thousand Dollars ($50,000) at any time and (y) laboratory Equipment having an aggregate book value not to exceed Two Hundred Thousand Dollars
($200,000) at any single location) with a bailee, warehouseman, or similar third party unless the third party has been notified of Bank’s security interest and Bank (a) has received an acknowledgment from the third party that it is holding
or will hold the Inventory or Equipment for Bank’s benefit or (b) is in possession of the warehouse receipt, where negotiable, covering such Inventory or Equipment. Except for Inventory sold in the ordinary course of business and except
for such other locations as Bank may approve in writing, Borrower shall keep the Inventory and Equipment (other than (x) movable items of personal property (such as laptop computers) having an aggregate book value not to exceed Fifty Thousand
Dollars ($50,000) at any time and (y) laboratory Equipment having an aggregate book value not to exceed Two Hundred Thousand Dollars ($200,000) at any single location) only at the location set forth in Section 10 and such other locations
of which Borrower gives Bank prior written notice and as to which Bank files a financing statement where needed to perfect its security interest. 

  

			
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 7.11    No Investment Company; Margin Regulation. Become or be
controlled by an “investment company,” within the meaning of the Investment Company Act of 1940, or become principally engaged in, or undertake as one of its important activities, the business of extending credit for the purpose of
purchasing or carrying margin stock, or use the proceeds of any Credit Extension for such purpose. 

8.    EVENTS OF DEFAULT. 
 Any one or more of the following events shall constitute an Event of Default by Borrower under this Agreement: 
 8.1    Payment Default. If Borrower fails to pay any of the Obligations when due; 
 8.2    Covenant Default. 

(a)    If Borrower fails to perform any obligation under Section 6.2, 6.4, 6.5, 6.6 or 6.7, or violates any of
the covenants contained in Article 7 of this Agreement; or 
 (b)    If Borrower fails or neglects to
perform or observe any other material term, provision, condition, covenant contained in this Agreement, in any of the Loan Documents, or in any other present or future agreement between Borrower and Bank and as to any default under such other term,
provision, condition or covenant that can be cured, has failed to cure such default within ten (10) days after Borrower receives notice thereof or any officer of Borrower becomes aware thereof; provided, however, that if the default cannot by
its nature be cured within the ten (10) day period or cannot after diligent attempts by Borrower be cured within such ten (10) day period, and such default is likely to be cured within a reasonable time, then Borrower shall have an
additional reasonable period (which shall not in any case exceed thirty (30) days) to attempt to cure such default, so long as Borrower continues to diligently attempt to cure such default, and within such reasonable time period the failure to
have cured such default shall not be deemed an Event of Default but no Credit Extensions will be made; 

8.3    Material Adverse Change. If there occurs any circumstance or circumstances that could reasonably be
expected to have a Material Adverse Effect. 
 8.4    Defective Perfection. If Bank shall receive at
any time following the Closing Date an SOS Report indicating that except for Permitted Liens, Bank’s security interest in any material part of the Collateral (determined in Bank’s reasonable discretion, exercised from the perspective of a
secured, commercial lender) is not prior to all other security interests or Liens of record reflected in the report; 

8.5    Attachment. If any material portion of Borrower’s assets is attached, seized, subjected to a writ
or distress warrant, or is levied upon, or comes into the possession of any trustee, receiver or person acting in a similar capacity and such attachment, seizure, writ or distress warrant or levy has not been removed, discharged or rescinded within
five (5) days, or if Borrower is enjoined, restrained, or in any way prevented by court order from continuing to conduct all or any material part of its business affairs, or if a judgment or other claim becomes a lien or encumbrance upon any
material portion of Borrower’s assets, or if a notice of lien, levy, or assessment is filed of record with respect to any of Borrower’s assets by the United States Government, or any department, agency, or instrumentality thereof, or by
any state, county, municipal, or governmental agency, and the same is not paid within five (5) days after Borrower receives notice thereof, provided that none of the foregoing shall constitute an Event of Default where such action or event is
stayed or an adequate bond has been posted pending a good faith contest by Borrower (provided that no Credit Extensions will be made during such cure period); 
 8.6    Insolvency. If Borrower becomes insolvent, or if an Insolvency Proceeding is commenced by Borrower, or if an Insolvency Proceeding is commenced against Borrower and is
not dismissed or stayed within thirty (30) days (provided that no Credit Extensions will be made prior to the dismissal of such Insolvency Proceeding); 
 8.7    Other Agreements. If there is a default or other failure to perform in any agreement to which Borrower is a party with a third party or parties resulting in a right by
such third party or parties, whether or 

  

			
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not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of One Hundred Thousand Dollars ($100,000) or that would reasonably be expected to have a Material Adverse
Effect; 
 8.8    Subordinated Debt. If Borrower makes any payment on account of Subordinated Debt,
except to the extent the payment is allowed under any subordination agreement entered into with Bank; 

8.9    Judgments; Settlements. If a judgment or judgments for the payment of money in an amount, individually
or in the aggregate, of at least One Hundred Thousand Dollars ($100,000) shall be rendered against Borrower and shall remain unsatisfied and unstayed for a period of ten (10) days (provided that no Credit Extensions will be made prior to the
satisfaction or stay of the judgment); or if a settlement or settlements is agreed upon for an amount individually or in the aggregate of at least Three Hundred Fifty Thousand Dollars ($350,000). 

8.10    Change in Control. If Borrower suffers or permits a Change in Control. 

8.11    Misrepresentations. If any material misrepresentation or material misstatement exists now or
hereafter in any warranty or representation set forth herein or in any certificate delivered to Bank by any Responsible Officer pursuant to this Agreement or to induce Bank to enter into this Agreement or any other Loan Document. 

9.    BANK’S RIGHTS AND REMEDIES. 

9.1    Rights and Remedies. Upon the occurrence and during the continuance of an Event of Default, Bank may,
at its election, without notice of its election and without demand, do any one or more of the following, all of which are authorized by Borrower: 
 (a)    Declare all Obligations, whether evidenced by this Agreement, by any of the other Loan Documents, or otherwise, immediately due and payable (provided that upon the occurrence of
an Event of Default described in Section 8.6 (insolvency), all Obligations shall become immediately due and payable without any action by Bank); 
 (b)    Demand that Borrower (i) deposit cash with Bank in an amount equal to the amount of any Letters of Credit remaining undrawn, and (ii) pay in advance all Letter of
Credit fees scheduled to be paid or payable over the remaining term of the Letters of Credit, and Borrower shall promptly deposit and pay such amounts; 
 (c)    Cease advancing money or extending credit to or for the benefit of Borrower under this Agreement or under any other agreement between Borrower and Bank; 

(d)    Settle or adjust disputes and claims directly with account debtors for amounts, upon terms and in whatever
order that Bank reasonably considers advisable; 
 (e)    Make such payments and do such acts as Bank
considers necessary or reasonable to protect its security interest in the Collateral. Borrower agrees to assemble the Collateral if Bank so requires, and to make the Collateral available to Bank as Bank may designate. Borrower authorizes Bank to
enter the premises where the Collateral is located, to take and maintain possession of the Collateral, or any part of it, and to pay, purchase, contest, or compromise any encumbrance, charge, or lien which in Bank’s determination appears to be
prior or superior to its security interest and to pay all expenses incurred in connection therewith. With respect to any of Borrower’s owned premises, Borrower hereby grants Bank a license to enter into possession of such premises and to occupy
the same, without charge, in order to exercise any of Bank’s rights or remedies provided herein, at law, in equity, or otherwise; 
 (f)    Set off and apply to the Obligations any and all (i) balances and deposits of Borrower held by Bank, and (ii) indebtedness at any time owing to or for the credit or
the account of Borrower held by Bank; 

  

			
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 (g)    Ship, reclaim, recover, store, finish, maintain, repair, prepare
for sale, advertise for sale, and sell (in the manner provided for herein) the Collateral. Bank is hereby granted a license or other right, solely pursuant to the provisions of this Section 9.1, to use, without charge, Borrower’s labels,
patents, copyrights, rights of use of any name, trade secrets, trade names, trademarks, service marks, and advertising matter, or any property of a similar nature, as it pertains to the Collateral, in completing production of, advertising for sale,
and selling any Collateral and, in connection with Bank’s exercise of its rights under this Section 9.1, Borrower’s rights under all licenses and all franchise agreements shall inure to Bank’s benefit; 

(h)    Sell the Collateral at either a public or private sale, or both, by way of one or more contracts or
transactions, for cash or on terms, in such manner and at such places (including Borrower’s premises) as Bank determines is commercially reasonable, and apply any proceeds to the Obligations in whatever manner or order Bank deems appropriate.
Bank may sell the Collateral without giving any warranties as to the Collateral. Bank may specifically disclaim any warranties of title or the like. This procedure will not be considered adversely to affect the commercial reasonableness of any sale
of the Collateral. If Bank sells any of the Collateral upon credit, Borrower will be credited only with payments actually made by the purchaser, received by Bank, and applied to the indebtedness of the purchaser. If the purchaser fails to pay for
the Collateral, Bank may resell the Collateral and Borrower shall be credited with the proceeds of the sale; 

(i)    Bank may credit bid and purchase at any public sale; 

(j)    Apply for the appointment of a receiver, trustee, liquidator or conservator of the Collateral, without notice
and without regard to the adequacy of the security for the Obligations and without regard to the solvency of Borrower, any guarantor or any other Person liable for any of the Obligations; and 

(k)    Any deficiency that exists after disposition of the Collateral as provided above will be paid immediately by
Borrower. 
 Bank may comply with any applicable state or federal law requirements in connection with a disposition of the Collateral and
compliance will not be considered adversely to affect the commercial reasonableness of any sale of the Collateral. 

9.2    Power of Attorney. Effective only upon the occurrence and during the continuance of an Event of
Default, Borrower hereby irrevocably appoints Bank (and any of Bank’s designated officers, or employees) as Borrower’s true and lawful attorney to: (a) send requests for verification of Accounts or notify account debtors of
Bank’s security interest in the Accounts; (b) endorse Borrower’s name on any checks or other forms of payment or security that may come into Bank’s possession; (c) sign Borrower’s name on any invoice or bill of lading
relating to any Account, drafts against account debtors, schedules and assignments of Accounts, verifications of Accounts, and notices to account debtors; (d) dispose of any Collateral; (e) make, settle, and adjust all claims under and
decisions with respect to Borrower’s policies of insurance; (f) settle and adjust disputes and claims respecting the accounts directly with account debtors, for amounts and upon terms which Bank determines to be reasonable; and
(g) file, in its sole discretion, one or more financing or continuation statements and amendments thereto, relative to any of the Collateral without the signature of Borrower where permitted by law; provided Bank may exercise such power of
attorney to sign the name of Borrower on any of the documents described in clause (g) above, regardless of whether an Event of Default has occurred. The appointment of Bank as Borrower’s attorney in fact, and each and every one of
Bank’s rights and powers, being coupled with an interest, is irrevocable until all of the Obligations have been fully repaid and performed and Bank’s obligation to provide advances hereunder is terminated. 

9.3    Accounts Collection. At any time after the occurrence and during the continuation of an Event of
Default, Bank may notify any Person owing funds to Borrower of Bank’s security interest in such funds and verify the amount of such Account. Borrower shall collect all amounts owing to Borrower for Bank, receive in trust all payments as
Bank’s trustee, and immediately deliver such payments to Bank in their original form as received from the account debtor, with proper endorsements for deposit. 
 9.4    Bank Expenses. If Borrower fails to pay any amounts or furnish any required proof of payment due to third persons or entities, as required under the terms of this
Agreement, then Bank may do any or all of the following after reasonable notice to Borrower: (a) make payment of the same or any part thereof; (b) set up 

  

			
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such reserves as Bank deems necessary to protect Bank from the exposure created by such failure; or (c) obtain and maintain insurance policies of the type discussed in Section 6.5 of
this Agreement, and take any action with respect to such policies as Bank deems prudent. Any amounts so paid or deposited by Bank shall constitute Bank Expenses, shall be immediately due and payable, and shall bear interest at the then applicable
rate hereinabove provided, and shall be secured by the Collateral. Any payments made by Bank shall not constitute an agreement by Bank to make similar payments in the future or a waiver by Bank of any Event of Default under this Agreement.

 9.5    Bank’s Liability for Collateral. Bank has no obligation to clean up or otherwise
prepare the Collateral for sale. All risk of loss, damage or destruction of the Collateral shall be borne by Borrower. 

9.6    No Obligation to Pursue Others. Bank has no obligation to attempt to satisfy the Obligations by
collecting them from any other person liable for them and Bank may release, modify or waive any collateral provided by any other Person to secure any of the Obligations, all without affecting Bank’s rights against Borrower. Borrower waives any
right it may have to require Bank to pursue any other Person for any of the Obligations. 

9.7    Remedies Cumulative. Bank’s rights and remedies under this Agreement, the Loan Documents, and all
other agreements shall be cumulative. Bank shall have all other rights and remedies not inconsistent herewith as provided under the Code, by law, or in equity. No exercise by Bank of one right or remedy shall be deemed an election, and no waiver by
Bank of any Event of Default on Borrower’s part shall be deemed a continuing waiver. No delay by Bank shall constitute a waiver, election, or acquiescence by it. No waiver by Bank shall be effective unless made in a written document signed on
behalf of Bank and then shall be effective only in the specific instance and for the specific purpose for which it was given. Borrower expressly agrees that this Section 9.7 may not be waived or modified by Bank by course of performance,
conduct, estoppel or otherwise. 
 9.8    Demand; Protest. Except as otherwise provided in this
Agreement, Borrower waives demand, protest, notice of protest, notice of default or dishonor, notice of payment and nonpayment and any other notices relating to the Obligations. 

10.    NOTICES. 
 Unless otherwise provided in this Agreement, all notices or demands by any party relating to this Agreement or any other agreement entered into in connection herewith shall be in writing and (except for
financial statements and other informational documents which may be sent by first-class mail, postage prepaid) shall be personally delivered or sent by a recognized overnight delivery service, certified mail, postage prepaid, return receipt
requested, or by telefacsimile to Borrower or to Bank, as the case may be, at its addresses set forth below: 
  

					
	 If to Borrower:
	  		  	diaDexus, Inc.
		  		  	343 Oyster Point Blvd.
		  		  	South San Francisco, CA 94080
		  		  	Attn: Chief Financial Officer
		  		  	FAX: (650) 246-6499

  

					
	 If to Bank:
	  		  	Comerica Bank
		  		  	M/C 7578
		  		  	39200 Six Mile Rd.
		  		  	Livonia, MI 48152
		  		  	Attn: National Documentation Services

  

					
	 with a copy to:
	  		  	Comerica Bank
		  		  	250 Lytton Avenue, 3rd Floor
		  		  	Palo Alto, CA 94301
		  		  	Attn: Brian G. Demmert, Senior Vice President
		  		  	FAX: 650) 462-6049


  

			
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 The parties hereto may change the address at which they are to receive notices hereunder, by
notice in writing in the foregoing manner given to the other. 
 11.     CHOICE OF LAW AND VENUE; JURY
TRIAL WAIVER. 
 This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of
California, without regard to principles of conflicts of law. Each of Borrower and Bank hereby submits to the exclusive jurisdiction of the State and Federal courts located in the State of California. THE UNDERSIGNED ACKNOWLEDGE THAT THE RIGHT TO
TRIAL BY JURY IS A CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED UNDER CERTAIN CIRCUMSTANCES. TO THE EXTENT PERMITTED BY LAW, EACH PARTY, AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS, HIS OR HER CHOICE, KNOWINGLY
AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES, WAIVES ANY RIGHT TO TRIAL BY JURY IN THE EVENT OF LITIGATION ARISING OUT OF OR RELATED TO THIS AGREEMENT OR ANY OTHER DOCUMENT, INSTRUMENT OR AGREEMENT BETWEEN THE UNDERSIGNED PARTIES.

 12.    REFERENCE PROVISION. 

12.1    In the event the Jury Trial Waiver set forth above is not enforceable, the parties elect to proceed under
this Judicial Reference Provision. 
 12.2    With the exception of the items specified in
Section 12.3, below, any controversy, dispute or claim (each, a “Claim”) between the parties arising out of or relating to this Agreement or any other document, instrument or agreement between the undersigned parties (collectively in
this Section, the “Loan Documents”), will be resolved by a reference proceeding in California in accordance with the provisions of Sections 638 et seq. of the California Code of Civil Procedure (“CCP”), or their successor
sections, which shall constitute the exclusive remedy for the resolution of any Claim, including whether the Claim is subject to the reference proceeding. Except as otherwise provided in the Loan Documents, venue for the reference proceeding will be
in the Superior Court in the County where the real property involved in the action, if any, is located or in a County where venue is otherwise appropriate under applicable law (the “Court”). 

12.3    The matters that shall not be subject to a reference are the following: (i) foreclosure of any security
interests in real or personal property, (ii) exercise of selfhelp remedies (including, without limitation, set-off), (iii) appointment of a receiver and (iv) temporary, provisional or ancillary remedies (including, without limitation,
writs of attachment, writs of possession, temporary restraining orders or preliminary injunctions). This Agreement does not limit the right of any party to exercise or oppose any of the rights and remedies described in clauses (i) and
(ii) or to seek or oppose from a court of competent jurisdiction any of the items described in clauses (iii) and (iv). The exercise of, or opposition to, any of those items does not waive the right of any party to a reference pursuant to
this Agreement. 
 12.4    The referee shall be a retired Judge or Justice selected by mutual written
agreement of the parties. If the parties do not agree within ten (10) days of a written request to do so by any party, then, upon request of any party, the referee shall be selected by the Presiding Judge of the Court (or his or her
representative). A request for appointment of a referee may be heard on an ex parte or expedited basis, and the parties agree that irreparable harm would result if ex parte relief is not granted. 

12.5    The parties agree that time is of the essence in conducting the reference proceedings. Accordingly, the
referee shall be requested, subject to change in the time periods specified herein for good cause shown, to (i) set the matter for a status and trial-setting conference within fifteen (15) days after the date of selection of the referee,
(ii) if practicable, try all issues of law or fact within one hundred twenty (120) days after the date of the conference and (iii) report a statement of decision within twenty (20) days after the matter has been submitted for
decision. 
 12.6    The referee will have power to expand or limit the amount and duration of discovery.
The referee may set or extend discovery deadlines or cutoffs for good cause, including a party’s failure to provide 

  

			
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requested discovery for any reason whatsoever. Unless otherwise ordered based upon good cause shown, no party shall be entitled to “priority” in conducting discovery, depositions may be
taken by either party upon seven (7) days written notice, and all other discovery shall be responded to within fifteen (15) days after service. All disputes relating to discovery which cannot be resolved by the parties shall be submitted
to the referee whose decision shall be final and binding. 
 12.7    Except as expressly set forth in this
Agreement, the referee shall determine the manner in which the reference proceeding is conducted including the time and place of hearings, the order of presentation of evidence, and all other questions that arise with respect to the course of the
reference proceeding. All proceedings and hearings conducted before the referee, except for trial, shall be conducted without a court reporter, except that when any party so requests, a court reporter will be used at any hearing conducted before the
referee, and the referee will be provided a courtesy copy of the transcript. The party making such a request shall have the obligation to arrange for and pay the court reporter. Subject to the referee’s power to award costs to the prevailing
party, the parties will equally share the cost of the referee and the court reporter at trial. 

12.8    The referee shall be required to determine all issues in accordance with existing case law and the statutory
laws of the State of California. The rules of evidence applicable to proceedings at law in the State of California will be applicable to the reference proceeding. The referee shall be empowered to enter equitable as well as legal relief, enter
equitable orders that will be binding on the parties and rule on any motion which would be authorized in a court proceeding, including without limitation motions for summary judgment or summary adjudication. The referee shall issue a decision at the
close of the reference proceeding which disposes of all claims of the parties that are the subject of the reference. Pursuant to CCP § 644, such decision shall be entered by the Court as a judgment or an order in the same manner as if the
action had been tried by the Court and any such decision will be final, binding and conclusive. The parties reserve the right to appeal from the final judgment or order or from any appealable decision or order entered by the referee. The parties
reserve the right to findings of fact, conclusions of laws, a written statement of decision, and the right to move for a new trial or a different judgment, which new trial, if granted, is also to be a reference proceeding under this provision.

 12.9    If the enabling legislation which provides for appointment of a referee is repealed (and no
successor statute is enacted), any dispute between the parties that would otherwise be determined by reference procedure will be resolved and determined by arbitration. The arbitration will be conducted by a retired judge or Justice, in accordance
with the California Arbitration Act §1280 through §1294.2 of the CCP as amended from time to time. The limitations with respect to discovery set forth above shall apply to any such arbitration proceeding. 

12.10    THE PARTIES RECOGNIZE AND AGREE THAT ALL CONTROVERSIES, DISPUTES AND CLAIMS RESOLVED UNDER THIS REFERENCE
PROVISION WILL BE DECIDED BY A REFEREE AND NOT BY A JURY. AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS, HIS OR HER OWN CHOICE, EACH PARTY KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES, AGREES
THAT THIS REFERENCE PROVISION WILL APPLY TO ANY CONTROVERSY, DISPUTE OR CLAIM BETWEEN OR AMONG THEM ARISING OUT OF OR IN ANY WAY RELATED TO, THIS AGREEMENT OR THE OTHER LOAN DOCUMENTS. 

13.    GENERAL PROVISIONS. 
 13.1    Successors and Assigns. This Agreement shall bind and inure to the benefit of the respective successors and permitted assigns of each of the parties and shall bind all
persons who become bound as a debtor to this Agreement; provided, however, that neither this Agreement nor any rights hereunder may be assigned by Borrower without Bank’s prior written consent, which consent may be granted or withheld in
Bank’s sole discretion. Bank shall have the right without the consent of or notice to Borrower to sell, transfer, negotiate, or grant participation in all or any part of, or any interest in, Bank’s obligations, rights and benefits
hereunder. 
 13.2    Indemnification. Borrower shall defend, indemnify and hold harmless Bank and
its officers, employees, and agents against: (a) all obligations, demands, claims, and liabilities claimed or asserted by any other party in connection with the transactions contemplated by this Agreement and/or the Loan Documents; and
(b) all losses or Bank Expenses in any way suffered, incurred, or paid by Bank, its officers, employees and 

  

			
	 16
	  	September 23, 2011









 
agents as a result of or in any way arising out of, following, or consequential to transactions between Bank and Borrower whether under this Agreement, or otherwise (including without limitation
reasonable attorneys fees and expenses), except for liabilities or losses caused by Bank’s gross negligence or willful misconduct. 
 13.3    Time of Essence. Time is of the essence for the performance of all obligations set forth in this Agreement. 

13.4    Severability of Provisions. Each provision of this Agreement shall be severable from every other
provision of this Agreement for the purpose of determining the legal enforceability of any specific provision. 

13.5    Correction of Loan Documents. Bank may correct patent errors and fill in any blanks in this Agreement
and the other Loan Documents consistent with the agreement of the parties. 
 13.6    Amendments in
Writing, Integration. All amendments to or terminations of this Agreement or the other Loan Documents must be in writing signed by the parties. All prior agreements, understandings, representations, warranties, and negotiations between the
parties hereto with respect to the subject matter of this Agreement and the other Loan Documents, if any, are merged into this Agreement and the Loan Documents. 
 13.7    Counterparts. This Agreement may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered,
shall be deemed to be an original, and all of which, when taken together, shall constitute but one and the same Agreement. 

13.8    Survival. All covenants, representations and warranties made in this Agreement shall continue in full
force and effect so long as any Obligations remain outstanding or Bank has any obligation to make any Credit Extension to Borrower. The obligations of Borrower to indemnify Bank with respect to the expenses, damages, losses, costs and liabilities
described in Section 13.2 shall survive until all applicable statute of limitations periods with respect to actions that may be brought against Bank have run. 
 13.9    Confidentiality. In handling any confidential information, Bank and all employees and agents of Bank shall exercise the same degree of care that Bank exercises with
respect to its own proprietary information of the same types to maintain the confidentiality of any non-public information thereby received or received pursuant to this Agreement except that disclosure of such information may be made (i) to the
subsidiaries or Affiliates of Bank in connection with their present or prospective business relations with Borrower, (ii) to prospective transferees or purchasers of any interest in the Loans, (iii) as required by law, regulations, rule or
order, subpoena, judicial order or similar order, (iv) as may be required in connection with the examination, audit or similar investigation of Bank, (v) to Bank’s accountants, auditors and regulators, and (vi) as Bank may
determine in connection with the enforcement of any remedies hereunder. Confidential information hereunder shall not include information that either: (a) is in the public domain or in the knowledge or possession of Bank when disclosed to Bank,
or becomes part of the public domain after disclosure to Bank through no fault of Bank; or (b) is disclosed to Bank by a third party, provided Bank does not have actual knowledge that such third party is prohibited from disclosing such
information. 
 [Balance of Page Intentionally Left Blank] 

  

			
	 17
	  	September 23, 2011









 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the
date first above written. 
  

	
	
	diaDexus, Inc.
	
	By: /s/ James P.
Panek                                        
        
	 Name: James P.
Panek                                        
        

	 Title:
CEO                                       
                         

	
	COMERICA BANK
	
	By: /s/ Brian
Demmert                                       
         
	 Name: Brian
Demmert                                       
         

	 Title:
SVP                                       
                             



 [Signature Page to Loan and Security Agreement]








 EXHIBIT A 
 DEFINITIONS 
 “Accounts” means all presently existing and hereafter arising accounts,
contract rights, payment intangibles and all other forms of obligations owing to Borrower arising out of the sale or lease of goods (including, without limitation, the licensing of software and other technology) or the rendering of services by
Borrower and any and all credit insurance, guaranties, and other security therefor, as well as all merchandise returned to or reclaimed by Borrower and Borrower’s Books relating to any of the foregoing. 

“Affiliate” means, with respect to any Person, any Person that owns or controls directly or indirectly such Person, any Person that controls or
is controlled by or is under common control with such Person, and each of such Person’s senior executive officers, directors, and partners. 
 “Bank Expenses” means all reasonable costs or expenses (including reasonable attorneys’ fees and expenses, whether generated in-house or by outside counsel) incurred in connection with the
preparation, negotiation, administration, and enforcement of the Loan Documents; reasonable Collateral audit fees; and Bank’s reasonable attorneys’ fees and expenses (whether generated in-house or by outside counsel) incurred in amending,
enforcing or defending the Loan Documents (including fees and expenses of appeal), incurred before, during and after an Insolvency Proceeding, whether or not suit is brought. 
 “Borrower State” means Delaware, the state under whose laws Borrower is organized. 

“Borrower’s Books” means all of Borrower’s books and records including: ledgers; records concerning Borrower’s assets or
liabilities, the Collateral, business operations or financial condition; and all computer programs, or tape files, and the equipment, containing such information. 
 “Business Day” means any day that is not a Saturday, Sunday, or other day on which banks in the State of California are authorized or required to close. 

“Cash” means unrestricted cash and cash equivalents. 
 “Change in Control” shall mean a transaction in which any “person” or “group” (within the meaning of Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934)
becomes the “beneficial owner” (as defined in Rule 13d-3 under the Securities Exchange Act of 1934), directly or indirectly, of a sufficient number of shares of all classes of stock then outstanding of Borrower ordinarily entitled to vote
in the election of directors, empowering such “person” or “group” to elect a majority of the Board of Directors of Borrower, who did not have such power before such transaction. 

“Chief Executive Office State” means California, where Borrower’s chief executive office is located. 

“Closing Date” means the date of this Agreement. 
 “Code” means the California Uniform Commercial Code as amended or supplemented from time to time. 
 “Collateral” means the property described on Exhibit B attached hereto and all Negotiable Collateral to the extent not described on Exhibit B, except to the extent any such
property (i) is nonassignable by its terms without the consent of the licensor thereof or another party (but only to the extent such prohibition on transfer is enforceable under applicable law, including, without limitation, Sections 9406 and
9408 of the Code), (ii) the granting of a security interest therein is contrary to applicable law, provided that upon the cessation of any such restriction or prohibition, such property shall automatically become part of the Collateral, or
(iii) constitutes the capital stock of a controlled foreign corporation (as defined in the IRC), in excess of sixty five percent (65%) of the voting power of all classes of capital stock of such controlled foreign corporations entitled to
vote; provided that in no case shall the definition of “Collateral” exclude any Accounts, proceeds of the disposition of any property, or general intangibles consisting of rights to payment. 

  

			
	 1
	  	September 23, 2011









 “Collateral State” means the state or states where the Collateral is located, which is California.

 “Contingent Obligation” means, as applied to any Person, any direct or indirect liability, contingent or otherwise, of that Person
with respect to (i) any indebtedness, lease, dividend, letter of credit or other obligation of another, including, without limitation, any such obligation directly or indirectly guaranteed, endorsed, co-made or discounted or sold with recourse
by that Person, or in respect of which that Person is otherwise directly or indirectly liable; (ii) any obligations with respect to undrawn letters of credit, corporate credit cards or merchant services issued for the account of that Person;
and (iii) all obligations arising under any interest rate, currency or commodity swap agreement, interest rate cap agreement, interest rate collar agreement, or other agreement or arrangement designated to protect a Person against fluctuation
in interest rates, currency exchange rates or commodity prices; provided, however, that the term “Contingent Obligation” shall not include endorsements for collection or deposit in the ordinary course of business. The amount of any
Contingent Obligation shall be deemed to be an amount equal to the stated or determined amount of the primary obligation in respect of which such Contingent Obligation is made or, if not stated or determinable, the maximum reasonably anticipated
liability in respect thereof as determined by such Person in good faith; provided, however, that such amount shall not in any event exceed the maximum amount of the obligations under the guarantee or other support arrangement. 

“Copyrights” means any and all copyright rights, copyright applications, copyright registrations and like protections in each work or
authorship and derivative work thereof, whether published or unpublished and whether or not the same also constitutes a trade secret, now or hereafter existing, created, acquired or held. 
 “Credit Extension” means the Growth Capital Advance or any other extension of credit by Bank to or for the benefit of Borrower hereunder. 

“Environmental Laws” means all laws, rules, regulations, orders and the like issued by any federal state, local foreign or other governmental
or quasi-governmental authority or any agency pertaining to the environment or to any hazardous materials or wastes, toxic substances, flammable, explosive or radioactive materials, asbestos or other similar materials. 

“Equipment” means all present and future machinery, equipment, tenant improvements, furniture, fixtures, vehicles, tools, parts and attachments
in which Borrower has any interest. 
 “ERISA” means the Employee Retirement Income Security Act of 1974, as amended, and the
regulations thereunder. 
 “Event of Default” has the meaning assigned in Article 8. 

“Final Payment” is a payment (in addition to and not a substitution for the regular monthly payments of principal plus accrued interest) due
and payable to Bank on the earliest to occur of (a) the Maturity Date, or (b) the acceleration of the Growth Capital Advance, or (c) the prepayment of the Growth Capital Advance pursuant to Section 2.1(b)(iv) or (v), equal to One
Hundred Thousand Dollars ($100,000). 
 “GAAP” means generally accepted accounting principles, consistently applied, as in effect from
time to time. 
 “Growth Capital Advance” means a cash advance or cash advances under the Growth Capital Line. 

“Growth Capital Interest Only End Date” means September 22, 2012. 
 “Growth Capital Line” means a Credit Extension of Five Million Dollars ($5,000,000). 

“Growth Capital Maturity Date” means September 23, 2015. 
 “Indebtedness” means (a) all indebtedness for borrowed money or the deferred purchase price of property or services, including without limitation reimbursement and other obligations with
respect to surety bonds and letters 

  

			
	 2
	  	September 23, 2011









 
of credit, (b) all obligations evidenced by notes, bonds, debentures or similar instruments, (c) all capital lease obligations, and (d) all Contingent Obligations. 

“Insolvency Proceeding” means any proceeding commenced by or against any Person or entity under any provision of the United States Bankruptcy
Code, as amended, or under any other bankruptcy or insolvency law, including assignments for the benefit of creditors, formal or informal moratoria, compositions, extension generally with its creditors, or proceedings seeking reorganization,
arrangement, or other relief. 
 “Intellectual Property” means all of Borrower’s right, title, and interest in and to the
following: 

	


	(a)	Copyrights, Trademarks and Patents; 

  

	(b)	Any and all trade secrets, and any and all intellectual property rights in computer software and computer software products now or hereafter existing, created, acquired
or held; 

  

	(c)	Any and all design rights which may be available to Borrower now or hereafter existing, created, acquired or held; 


 

	(d)	Any and all claims for damages by way of past, present and future infringement of any of the rights included above, with the right, but not the obligation, to sue for
and collect such damages for said use or infringement of the intellectual property rights identified above; 

  

	(e)	All licenses or other rights to use any of the Copyrights, Patents or Trademarks, and all license fees and royalties arising from such use to the extent permitted by
such license or rights; and 

  

	(f)	All amendments, renewals and extensions of any of the Copyrights, Trademarks or Patents. 

 “Inventory” means all present and future inventory in which Borrower has any interest. 

“Investment” means any beneficial ownership of (including stock, partnership or limited liability company interest or other securities) any
Person, or any loan, advance or capital contribution to any Person. 
 “IRC” means the Internal Revenue Code of 1986, as amended, and
the regulations thereunder. 
 “Letter of Credit” means a commercial or standby letter of credit or similar undertaking issued by Bank
at Borrower’s request. 
 “Lien” means any mortgage, lien, deed of trust, charge, pledge, security interest or other encumbrance.

 “Loan Documents” means, collectively, this Agreement, any note or notes executed by Borrower, and any other document, instrument or
agreement entered into in connection with this Agreement, all as amended or extended from time to time. 
 “Material Adverse Effect”
means (i) a material adverse change in Borrower’s business, operations or condition (financial or otherwise), or (ii) a material impairment in the prospect of repayment of all or any portion of the Obligations or in otherwise
performing Borrower’s obligations under the Loan Documents, (iii) a material impairment in the perfection, value or priority of Bank’s security interests in the Collateral. 
 “Negotiable Collateral” means all of Borrower’s present and future letters of credit of which it is a beneficiary, drafts, instruments (including promissory notes), securities, documents of
title, and chattel paper, and Borrower’s Books relating to any of the foregoing. 
 “Obligations” means all debt, principal,
interest, Bank Expenses, the Prepayment Fee, the Final Payment and other amounts owed to Bank by Borrower pursuant to this Agreement or any other agreement, whether absolute or contingent, due or to become due, now existing or hereafter arising,
including any interest that accrues after the 

  

			
	 3
	  	September 23, 2011









 
commencement of an Insolvency Proceeding and including any debt, liability, or obligation owing from Borrower to others that Bank may have obtained by assignment or otherwise. 

“Patents” means all patents, patent applications and like protections including without limitation improvements, divisions, continuations,
renewals, reissues, extensions and continuations-in-part of the same. 
 “Periodic Payments” means all installments or similar
recurring payments that Borrower may now or hereafter become obligated to pay to Bank pursuant to the terms and provisions of any instrument, or agreement now or hereafter in existence between Borrower and Bank. 

“Permitted Indebtedness” means: 
  

	(a)	Indebtedness of Borrower in favor of Bank arising under this Agreement or any other Loan Document; 


 

	(b)	Indebtedness existing on the Closing Date and disclosed in the Schedule; 

  

	(c)	Indebtedness not to exceed Two Hundred Fifty Thousand Dollars ($250,000) in the aggregate in any fiscal year of Borrower secured by a lien described in clause
(c) of the defined term “Permitted Liens,” provided such Indebtedness does not exceed the lesser of the cost or fair market value of the equipment financed with such Indebtedness; 


 

	(d)	Subordinated Debt; 

  

	(e)	Indebtedness to trade creditors incurred in the ordinary course of business; and 


 

	(f)	Extensions, refinancings and renewals of any items of Permitted Indebtedness, provided that the principal amount is not increased or the terms modified to impose more
burdensome terms upon Borrower or its Subsidiary, as the case may be. 

 “Permitted Investment” means: 

 

	(a)	Investments existing on the Closing Date disclosed in the Schedule; 

  

	(b)	(i) Marketable direct obligations issued or unconditionally guaranteed by the United States of America or any agency or any State thereof maturing within one
(1) year from the date of acquisition thereof, (ii) commercial paper maturing no more than one (1) year from the date of creation thereof and currently having rating of at least A-2 or P-2 from either Standard & Poor’s
Corporation or Moody’s Investors Service, (iii) Bank’s certificates of deposit maturing no more than one (1) year from the date of investment therein, and (iv) Bank’s money market accounts; 


 

	(c)	Repurchases of stock from former employees or directors of Borrower under the terms of applicable repurchase agreements (i) in an aggregate amount not to exceed
One Hundred Thousand Dollars ($100,000) in any fiscal year, provided that no Event of Default has occurred, is continuing or would exist after giving effect to the repurchases, or (ii) in any amount where the consideration for the repurchase is
the cancellation of indebtedness owed by such former employees to Borrower regardless of whether an Event of Default exists; 

  

	(d)	Investments accepted in connection with Permitted Transfers; 

  

	(e)	Investments of Subsidiaries in or to other Subsidiaries or Borrower and Investments by Borrower in Subsidiaries not to exceed One Hundred Thousand Dollars ($100,000) in
the aggregate in any fiscal year; 

  

	(f)	 Investments not to exceed (i) Two Hundred Fifty Thousand Dollars ($250,000) in the aggregate in any fiscal year consisting of travel advances and
employee relocation loans and other employee loans and advances in the ordinary course of business, and (ii) One Hundred Thousand Dollars ($100,000) in the 



  

			
	 4
	  	September 23, 2011










	 	
aggregate in any fiscal year consisting of loans to employees, officers or directors relating to the purchase of equity securities of Borrower or its Subsidiaries pursuant to employee stock
purchase plan agreements approved by Borrower’s Board of Directors; 

  

	(g)	Investments (including debt obligations) received in connection with the bankruptcy or reorganization of customers or suppliers and in settlement of delinquent
obligations of, and other disputes with, customers or suppliers arising in the ordinary course of Borrower’s business; 

  

	(h)	Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and suppliers who are not Affiliates, in the ordinary
course of business, provided that this subparagraph (h) shall not apply to Investments of Borrower in any Subsidiary; and 

  

	(i)	Joint ventures or strategic alliances in the ordinary course of Borrower’s business consisting of the non-exclusive licensing of technology, the development of
technology or the providing of technical support, provided that any cash Investments by Borrower do not exceed One Hundred Thousand Dollars ($100,000) in the aggregate in any fiscal year. 


“Permitted Liens” means the following: 
  

	(a)	Any Liens existing on the Closing Date and disclosed in the Schedule (excluding Liens to be satisfied with the proceeds of the Advances) or arising under this Agreement
or the other Loan Documents; 

  

	(b)	Liens for taxes, fees, assessments or other governmental charges or levies, either not delinquent or being contested in good faith by appropriate proceedings and for
which Borrower maintains adequate reserves, provided the same have no priority over any of Bank’s security interests; 

  

	(c)	Liens not to exceed Two Hundred Fifty Thousand Dollars ($250,000) in the aggregate in any fiscal year (i) upon or in any Equipment (acquired or held by Borrower or
any of its Subsidiaries to secure the purchase price of such Equipment or indebtedness incurred solely for the purpose of financing the acquisition or lease of such Equipment, or (ii) existing on such Equipment at the time of its acquisition,
provided that the Lien is confined solely to the property so acquired and improvements thereon, and the proceeds of such Equipment; 

  

	(d)	Liens incurred in connection with the extension, renewal or refinancing of the indebtedness secured by Liens of the type described in clauses (a) through
(c) above, provided that any extension, renewal or replacement Lien shall be limited to the property encumbered by the existing Lien and the principal amount of the indebtedness being extended, renewed or refinanced does not increase;


  

	(e)	Liens arising from judgments, decrees or attachments in circumstances not constituting an Event of Default under Sections 8.5 (attachment) or 8.9 (judgments); and


  

	(f)	Liens in favor of other financial institutions arising in connection with Borrower’s deposit accounts held at such institutions to secured standard fees for
deposit services charged by, but not financing made available by such institutions, provided that Bank has a perfected security interest in the amounts held in such deposit accounts. 


“Permitted Transfer” means the conveyance, sale, lease, transfer or disposition by Borrower or any Subsidiary of: 

 

	(a)	Inventory in the ordinary course of business; 

  

	(b)	Non-exclusive licenses and similar arrangements for the use of the property of Borrower or its Subsidiaries in the ordinary course of business;


  

	(c)	Worn-out or obsolete Equipment; 


  

			
	 5
	  	September 23, 2011










	(d)	Transfers of Equipment in connection with sale-leaseback transactions in which Borrower is the beneficiary; 


 

	(e)	The Equipment set forth on Annex II hereto; or 

  

	(f)	Other assets of Borrower or its Subsidiaries that do not in the aggregate exceed One Hundred Thousand Dollars ($100,000) during any fiscal year.


 “Person” means any individual, sole proprietorship, partnership, limited liability company, joint venture, trust,
unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or governmental agency. 
 “Prepayment Fee” means with respect to the Growth Capital Advance subject to prepayment prior to the Growth Capital Maturity Date, whether by mandatory or voluntary prepayment, acceleration or
otherwise, an additional fee payable to Bank in amount equal to: 
 (i) for a prepayment made on or after the Closing Date
through and including the first anniversary thereof, one percent (1.00%) of the principal amount of the Growth Capital Advance prepaid; and 
 (ii) for a prepayment made thereafter, no Prepayment Fee shall be applicable. 
 “Prohibited
Territory” means any person or country listed by the Office of Foreign Assets Control of the United States Department of Treasury as to which transactions between a United States Person and that territory are prohibited. 

“Responsible Officer” means each of the Chief Executive Officer, the Chief Operating Officer, the Chief Financial Officer or the Controller of
Borrower. 
 “Schedule” means the schedule of exceptions attached hereto and approved by Bank, if any. 

“SOS Reports” means the official reports from the Secretaries of State of each Collateral State, Chief Executive Office State and the Borrower
State and other applicable federal, state or local government offices identifying all current security interests filed in the Collateral and Liens of record as of the date of such report. 
 “Subordinated Debt” means any debt incurred by Borrower that is subordinated in writing to the debt owing by Borrower to Bank on terms reasonably acceptable to Bank (and identified as being such
by Borrower and Bank). 
 “Subsidiary” means any corporation, partnership or limited liability company or joint venture in which
(i) any general partnership interest or (ii) more than fifty percent (50%) of the stock, limited liability company interest or joint venture of which by the terms thereof ordinary voting power to elect the Board of Directors, managers
or trustees of the entity, at the time as of which any determination is being made, is owned by Borrower, either directly or through an Affiliate. 
 “Trademarks” means any trademark and servicemark rights, whether registered or not, applications to register and registrations of the same and like protections, and the entire goodwill of the
business of Borrower connected with and symbolized by such trademarks. 
  

  

			
	 6
	  	September 23, 2011










			
	 DEBTOR
	    	diaDexus, Inc.
		
	 SECURED PARTY:
	    	COMERICA BANK

 EXHIBIT B 
 COLLATERAL DESCRIPTION ATTACHMENT TO LOAN AND SECURITY AGREEMENT 
 All personal property of
Borrower (herein referred to as “Borrower” or “Debtor”) whether presently existing or hereafter created or acquired, and wherever located, including, but not limited to: 

All personal property of Debtor of every kind, whether presently existing or hereafter created or acquired, and wherever located,
including but not limited to: (a) all accounts (including health-care-insurance receivables), chattel paper (including tangible and electronic chattel paper), deposit accounts, documents (including negotiable documents), equipment (including
all accessions and additions thereto), general intangibles (including payment intangibles and software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be furnished
under a contract of service, and including returns and repossessions), investment property (including securities and securities entitlements), letter of credit rights, money, and all of Debtor’s books and records with respect to any of the
foregoing, and the computers and equipment containing said books and records; and (b) any and all cash proceeds and/or noncash proceeds thereof, including, without limitation, insurance proceeds, and all supporting obligations and the security
therefor or for any right to payment. All terms above have the meanings given to them in the California Uniform Commercial Code, as amended or supplemented from time to time. 
 Notwithstanding the foregoing, the Collateral shall not include (x) any copyrights, patents, trademarks, trade names, trade secrets, service marks, domain names and registrations, applications,
renewals and extensions therefor, now owned or hereafter acquired, or other proprietary rights in technology, or any claims for damages by way of any past, present and future infringement of any of the foregoing (collectively, the “Intellectual
Property”); provided, however, that the Collateral shall include all accounts and general intangibles that consist of rights to payment from the sale, licensing or disposition of all or any part of, or rights in, the Intellectual Property (the
“Rights to Payment”); or (y) any property (i) which is nonassignable by its terms without the consent of the licensor thereof or another party (but only to the extent such prohibition on transfer is enforceable under applicable
law, including, without limitation, Sections 9406 and 9408 of the Code), or (ii) to the extent the granting of a security interest therein is contrary to applicable law, provided that upon the cessation of any such restriction or prohibition,
such property shall automatically become part of the Collateral. Notwithstanding the foregoing, if a judicial authority (including a U.S. Bankruptcy Court) holds that a security interest in the underlying Intellectual Property is necessary to have a
security interest in the Rights to Payment, then the Collateral shall automatically, and effective as of September 23, 2011, include the Intellectual Property to the extent necessary to permit perfection of Bank’s security interest in the
Rights to Payment. 

  

			
	 7
	  	









 EXHIBIT C 
 TECHNOLOGY & LIFE SCIENCES DIVISION 
 LOAN ANALYSIS

 LOAN ADVANCE/PAYDOWN REQUEST FORM 
 DEADLINE FOR SAME DAY PROCESSING IS 3:00* P.M., P.S.T. 
 DEADLINE FOR EQUIPMENT
ADVANCES IS 3:00 P.M., P.S.T.** 
 DEADLINE FOR WIRE TRANSFERS IS 1:30 P.M., P.S.T. 

*At month end and the day before a holiday, the cut off time is 1:30 P.M., P.S.T. 

**Subject to 3 day advance notice. 
  

											
	To: Loan Analysis	 	DATE:	 	 	 		 	TIME:	 	 
	 FAX #: (650) 462-6061
	 		 		 		 		 	

  

											
	 	 	 	 	 
	FROM:	 	 	 		 	 TELEPHONE REQUEST (For Bank Use Only):
	 	 
	 	 	Borrower’s Name	 		 		 		 	 
	 FROM:
	 	 	 		 	The following person is authorized to request the loan payment transfer/loan advance on the
designated account and is known to me.
	 	 	 
	 	 	Authorized Signer’s Name	 		 
	 			 		 
	FROM:	 	 	 		 		 	 	 	 
	 	 	Authorized Signature (Borrower)	 		 		 	 Authorized Request & Phone #
	 	 
	 			 		 
	PHONE #:	 	 	 		 		 	 	 	 
	 	 		 		 		 	 Received by (Bank) & Phone #
	 	 
	FROM ACCOUNT#:	 	 	 		 		 		 	 
	 (please include Note number, if applicable)
	 		 	 	 	 
	TO ACCOUNT #:	 	 	 		 		 	 Authorized Signature (Bank)
	 	 
	 (please include Note
number, if applicable)
	 	 	 	 	 	 

  

													
	 REQUESTED TRANSACTION TYPE

 
	 	REQUESTED DOLLAR AMOUNT	 	 	 	For Bank Use Only
	PRINCIPAL INCREASE* (ADVANCE)	 	$                           
                               	 		 	Date Rec’d:	 		 	 
	PRINCIPAL PAYMENT (ONLY)	 	$                           
                               	 		 	Time:	 		 	 
	 	 		 		 		 	Comp. Status:	 	YES	 	NO
	OTHER INSTRUCTIONS:	 		 		 		 	Status Date:	 		 	 
	 	 		 	Time:	 		 	 
	 	 		 	Approval:	 		 	 
	 	 		 		 		 	 
	 	 	 	 	 	 	 	 	 

 All representations and warranties of Borrower stated in the Loan Agreement are true, correct and complete in all
material respects as of the date of the telephone request for and advance confirmed by this Borrowing Certificate; provided, however, that those representations and warranties the date expressly referring to another date shall be true, correct and
complete in all material respects as of such date. 
  

					
	*IS THERE A WIRE REQUEST TIED TO THIS LOAN ADVANCE? (PLEASE CIRCLE ONE)	  	YES	  	NO
	If YES, the Outgoing Wire Transfer Instructions must be completed below.


 

									
	OUTGOING WIRE TRANSFER INSTRUCTIONS	 	 Fed Reference Number

 
	 	Bank Transfer Number
	The items marked with an asterisk
(*) are required to be completed.
	 *Beneficiary Name
	 	 
	 *Beneficiary Account Number
	 	 
	 *Beneficiary Address
	 	 
	 Currency Type
	 	US DOLLARS
ONLY
	 *ABA Routing Number (9 Digits)
	 	 
	 *Receiving Institution Name
	 	 
	 *Receiving Institution Address
	 	 
	 *Wire Amount
	 	$	 	 








 EXHIBIT D 
 COMPLIANCE CERTIFICATE 
  

			
	Please send all Required Reporting to:	  	Comerica Bank
		  	Technology & Life Sciences Division
		  	Loan Analysis Department
		  	Five Palo Alto Square, Suite 800
		  	3000 El Camino Real
		  	Palo Alto, CA 94306
		  	Phone: (650) 846-6820
		  	Fax: (650) 462-6061

 FROM:                 diaDexus,
Inc. 
 The undersigned authorized Officer of diaDexus, Inc. (“Borrower”), hereby certifies that in accordance with the terms and
conditions of the Loan and Security Agreement between Borrower and Bank (the “Agreement”), (i) Borrower is in complete compliance for the period ending
                                         
        with all required covenants, including without limitation the ongoing registration of intellectual property rights in accordance with Section 6.8, except as noted below and (ii) all
representations and warranties of Borrower stated in the Agreement are true and correct in all material respects as of the date hereof. Attached herewith are the required documents supporting the above certification. The Officer further certifies
that all quarterly and annual financial statements attached are prepared in accordance with Generally Accepted Accounting Principles (GAAP) and are consistently applied from one period to the next except as explained in an accompanying letter or
footnotes. 
 Please indicate compliance status by circling Yes/No under “Complies” or “Applicable” column. 

 

							
	REPORTING COVENANTS	  	REQUIRED	  	COMPLIES
				
	Company Prepared Monthly F/S	  	Monthly, w/in 30 days	  	YES	  	NO
	Company Prepared Quarterly F/S	  	Quarterly, w/in 45 days	  	YES	  	NO
	Compliance Certificate	  	Monthly, within 30 days	  	YES	  	NO
	CPA Audited, Unqualified F/S	  	Annually, within 120 days of FYE	  	YES	  	NO
	Annual Business Plan (incl. operating budget)	  	By 1/31	  	YES	  	NO
	Audit	  	Semi-annual	  	YES	  	NO
				
	10-Q	  	Quarterly, within 5 days of SEC filing (50 days)	  	YES	  	NO
	10-K	  	Annually, within 5 days of SEC filing (95 days)	  	YES	  	NO
				
	Total amount of Borrower’s cash and investments	  	Amount:
$                                         
           	  	YES	  	NO
	Total amount of Borrower’s cash and investments maintained with Bank	  	Amount:
$                                         
           	  	YES	  	NO

  

							
	REPORTING COVENANTS	  	DESCRIPTION	  	APPLICABLE
				
	Legal Action > $100,000 (Sect. 6.2(iv))	  	Notify promptly upon
notice                                      
	  	YES	  	NO
	Inventory Disputes > $100,000 (Sect. 6.3)	  	Notify promptly upon
notice                                      
	  	YES	  	NO
	Mergers & Acquisitions > $100,000 (Sect. 7.3)	  	Notify promptly upon
notice                                      
	  	YES	  	NO
	Cross default with other agreements	  	Notify promptly upon
notice                                      
	  	YES	  	NO
	> $100,000 (Sect. 8.7)	  		  	YES	  	NO
	Judgment > $100,000 (Sect. 8.9)	  	Notify promptly upon
notice                                      
	  	YES	  	NO









									
	 FINANCIAL COVENANTS

 
	  	REQUIRED	  	ACTUAL	  	COMPLIES
	 TO BE TESTED MONTHLY, UNLESS OTHERWISE NOTED:
  
	  		  	
	Minimum Revenues (Performance to Plan)	  	80% of Plan*	  	                %	  	YES	  	NO
				
	 OTHER COVENANTS
  
	  	REQUIRED	  	ACTUAL	  	COMPLIES
	Permitted Indebtedness for equipment leases	  	<$250,000	  	 	  	YES	  	NO
	Permitted Investments for stock repurchase	  	<$100,000	  	 	  	YES	  	NO
	Permitted Investments for subsidiaries	  	<$100,000	  	 	  	YES	  	NO
	Permitted Investments for employee loans	  	<$250,000	  	 	  	YES	  	NO
	Permitted Investments for joint ventures	  	<$100,000	  	 	  	YES	  	NO
	Permitted Liens for equipment leases	  	<$250,000	  	 	  	YES	  	NO
	Permitted Transfers	  	<$100,000**	  	 	  	YES	  	NO

  

	*	See Annex I to Schedule of Exceptions 

  

	**	See also Annex II to Schedule of Exceptions 


Please Enter Below Comments Regarding Violations: 
 The Officer further acknowledges that at any time Borrower is not in compliance with all the terms set forth in the Agreement, including, without limitation, the financial covenants, no credit extensions
will be made. 
  

	
	 Very truly yours,
  

	
	 
	 Authorized Signer
  

	
	Name:
	
	
	  
 Title:









 SCHEDULE OF EXCEPTIONS 

TO LOAN AND SECURITY AGREEMENT 
 Permitted Indebtedness (Exhibit A) 
 Premium Finance Agreement, Disclosure Statement and
Security Agreement, by and between diaDexus, Inc. and Imperial Credit Corporation; provided that Borrower’s aggregate liability thereunder does not exceed $150,000. 
 Permitted Investments (Exhibit A) 
 None. 

Permitted Liens (Exhibit A) 
 Lien on
insurance premiums granted pursuant to the Premium Finance Agreement, Disclosure Statement and Security Agreement, by and between diaDexus, Inc. and Imperial Credit Corporation; provided that Borrower’s aggregate liability thereunder does not
exceed $150,000. 
 Prior Names (Section 5.5) 
 VaxGen, Inc. 
 Litigation (Section 5.6) 

None. 
 Inbound Licenses (Section 5.12)

 Collaboration and License Agreement, dated as of September 2, 1997 (the “Collaboration Agreement”), by and among diaDexus, LLC,
SmithKline Beecham Corp., SmithKline Beecham p.l.c., and Incyte Pharmaceuticals, Inc. 
 Amendment No. 1 to the Collaboration Agreement,
dated as of February , 1998. 
 Amendment No. 2 to the Collaboration Agreement, dated as of July , 1998. 

Amendment to the Collaboration Agreement, dated as of May 4, 1999. 
 Amendment No. 3 to the Collaboration Agreement, dated as of July 28, 1999. 
 Amendment
No. 4 to the Collaboration Agreement, dated as of February 17, 2000. 
 Letter Amendment to Collaboration Agreement, dated as of
March 30, 2000. 
 [*] 
 Side
Letter to the License Agreement, dated as of February 28, 2005. 
 [*] 
 Diagnostics License Agreement, dated December 9, 2004, by and between diaDexus, Inc. and ICOS Corp. 
 [*] 
 [*] 
 [*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions. 







 [*] 
 SB/HGS Diagnostic License Agreement, effective as of July 24, 1997, by and among SmithKline Beecham Corp., SmithKline Beecham p.l.c. and Human Genome Services, Inc. 

[*] 
 [*] Certain information in this
document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 







 ANNEX I 
 (Board of Directors-approved Monthly Projections) 
 [hard copy to be
attached] 

  

			
	 1
	  	









 [*] 
 [*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions. 

  

			
	 2
	  	









 ANNEX II 
 (Equipment which may be disposed of as Permitted Transfer) 
 [hard copy to be
attached] 

  

			
	 1
	  	









 diaDexus, Inc. 
 Assets Held For Sale - Details 
 As of September 14, 2011 

 

	
	 Description

	 Cabinets x 18

	 Buffer Preparation Tank 2000L, SS w/Agitator A-2100, jacketed

	Buffer Prep Tank w/ Lighning EV1PFloor Mount Agitator - A2110 w/ portable tank, Buffer Prep Tank Control panel pH/conductivity monitoring
	 Floor Scale - SC2100

	 Safeaire Hood

	 Balance SG16001, 16,100 gram capacity X 1 gram readability, or 3200 g at .1 gram, 360mm X280MM pan size

	 HOT PLATE/STIR,10X10 120VPC620

	 Climet Particle Counter CI-450

	 Portable return pump w/ cart

	 8’ Biosafety Cabinet, 541934 sn 10774ClassIIA A/BC 2003 model

	 5’ Baker Co, edgeguard, laminar Flow Hood and blue Pump

	 BALANCE SG16001, 16,100 gram capacity X 1 gram readability, or 3200 g at .1 gram, 360mm X280MM pan size

	 Wave Warmer/Mixer - 20/50EH

	 Climet Particle Counter CI-450

	 Climet Particle Counter CI-450

	 Climet Particle Counter CI-450

	200L Bioreactor with a master flex easy load pump drive and 7 Watson Marlow pumps (two blue 300 series, three yellow 600series, two dark blue 700 series)
	 1000L Bioreactor - R-1400

	 1000 L BRX agitator

	 Baldor Pump with Cart

	 STFIR, Tube Fuser (1/4”,3/8”,1/2”, 3/4”)

	 PHI 660 PH MTR,BNCHTP,PH,MV

	 Micro Osmometer Series 3300

	 Liftoflex Lift - Series 20500, 275 lbs max

	 Millipore Integritest ITX Exacta - Filter Integrity Tester

	 Millipore Integritest ITX Exacta - Filter Integrity Tester

	 Precision Water Bath

	 Scale PG10003-2

	 Barnstead MaxQ4000 Shaker E Class

	 60 cm diameter column

	 Small column press

	 60 cm diameter column

	 60 cm diameter column

	 Millipore K Prime 400

	 Millipore K Prime 400

	 Slurry Vessel

	 PHI 660 PH MTR,BNCHTP,PH,MV

	 Wave Rocker 20/50 EH

	 Sartorius Scale

	 Floor Scale

	 Lynx Floor Scale

	 Levtech Monarch Mixer

	 Levtech Monarch Mixer

	 Millipore K Prime 40-II

	 Millipore TFF

	 BALANCE SG16001, 16,100 gram capacity X 1 gram readability, or 3200 g at .1 gram, 360mm X280MM pan size

	 Millipore Isopak Slurry Transfer Skid

	 Harvest Storage Vessel - V1530, 1,500 lt.

	 Agitator for V1530

	 Harvest Storage Vessel Vent Filter - F1530









 diaDexus, Inc. 
 Assets Held For Sale - Details 
 As of September 14, 2011 

 

	
	 Description

	 Harvest Storage Vessel Filter - F1540

	 UF/DF Skid - TFF2400

	 Harvest Depth Filter System- F1520

	 Disc Stack BTPX-205 steam-sterilizable centrifuge, cell separation up to 1200 L/hour and Containment tank

	 Fristam Pump with cart

	 Upstream Autoclave - AUT3200

	 Clean Steam Sampler

	 Millipore Millistak + Pod holder

	 COP Tank 200 Gallon

	 500L SS bin for buffers (x16)

	 200L SS bin for buffers (x4)

	 Plastic Resin Bins (x8)

	 Resin Bin holders (x8)

	 Plastic Carboys (x5)

	 Millipore Filter housings - Quantity (x8)

	 5’, Purifier, Class II Biosafety Cabinet,

	 8’, 36212/36213, Type II Bio Safety Hood

	 8’, 36212/36213, Type II Bio Safety Hood

	 8’, 36212043726, Type II Bio Safety Hood

	 5’ Fume Hood w/ Cabinet, 2 each

	 5’ Fume Hood w/ Cab., 4 each

	 45 Gallon, A145, Flammable Cab, 3 each

	 8’ Steriguard, SQ600-SL-44090V

	 6’, Purifier, Class II, Biosafety Cabinet

	 6’, 36212043726, Type II Biosafety Cabinets, 2 each

	 12 gal, Flammable Storage Cabinet

	 6’ Fume Hood w/ Cabinet

	 6’, 1186, Class II A/BB Biosafety cabinet

	 6’, 36212043726, Type II Biosafety Cabinet

	 Floor Scale - SC2100

	 GS-6KR, refrigerated table top centrifuge

	 SS Tank, Jacketed, 6,000liter

	 4 chamber distiller systems., Integrated by Flour Daniels2003 vintage, 700 L/hr WFI & 1100 ponds of clean
steam/hr,

	 DI Water System, 7 gals/min, 12,000 liter storage tank, 2 ea

	 Hydrogen Dewer

	 Cold Room

	 House Vacuum System w/ tank 2 ea. 50 Gallon/200 Gallon117 CFM, sn C-12690

	 Oil Free Air Compressor w/ Tank and Zander dryer

	 Neutralization System

	 Boiler, natural Gas, “Pro fire”, max 5,500 MBH, sn 9144 and 8502 2 ea.

	 Cold Room

	 180 Ton Chiller

	 CIP System

	 Electric walk-behind stacker

	 Electric walk-behind stacker

	 Forklift, Propane, low profile, hard wheel, 5800lb cap,









 Corporation Resolutions and Incumbency Certification 

Authority to Procure Loans 

 
 I certify that I am the duly elected and qualified
Secretary of diaDexus, Inc.; that the following is a true and correct copy of resolutions duly adopted by the Board of Directors of the Corporation in accordance with its bylaws and applicable statutes. 

Copy of Resolutions: 
 Be it Resolved,
That: 
  

	1.	Any one (1) of the following
                                         
       _(insert titles only) of the Corporation are/is authorized, for, on behalf of, and in the name of the Corporation to: 


 

	 	(a)	Negotiate and procure loans, letters of credit and other credit or financial accommodations from Comerica Bank (“Bank”), a Texas banking association, from
time to time, in an unlimited amount. 

  

	 	(b)	Discount with the Bank, commercial or other business paper belonging to the Corporation made or drawn by or upon third parties, without limit as to amount;


  

	 	(c)	Purchase, sell, exchange, assign, endorse for transfer and/or deliver certificates and/or instruments representing stocks, bonds, evidences of Indebtedness or other
securities owned by the Corporation, whether or not registered in the name of the Corporation; 

  

	 	(d)	Give security for any liabilities of the Corporation to the Bank by grant, security interest, assignment, lien, deed of trust or mortgage upon any real or personal
property, tangible or intangible of the Corporation; 

  

	 	(e)	Issue a warrant or warrants to purchase the Corporation’s capital stock; and 


 

	 	(f)	Execute and deliver in form and content as may be required by the Bank any and all notes, evidences of Indebtedness, applications for letters of credit, guaranties,
subordination agreements, loan and security agreements, financing statements, assignments, liens, deeds of trust, mortgages, trust receipts and other agreements, instruments or documents to carry out the purposes of these Resolutions, ,and any and
all amendments or modifications thereto, any or all of which may relate to all or to substantially all of the Corporation’s property and assets. 

  

	2.	Said Bank be and it is authorized and directed to pay the proceeds of any such loans or discounts as directed by the persons so authorized to sign, whether so payable
to the order of any of said persons in their individual capacities or not, and whether such proceeds are deposited to the individual credit of any of said persons or not; 


 

	3.	Any and all agreements, instruments and documents previously executed and acts and things previously done to carry out the purposes of these Resolutions are ratified,
confirmed and approved as the act or acts of the Corporation. 

  

	4.	These Resolutions shall continue in force, and the Bank may consider the holders of said offices and their signatures to be and continue to be as set forth in a
certified copy of these Resolutions delivered to the Bank, until notice to the contrary in writing is duly served on the Bank (such notice to have no effect on any action previously taken by the Bank in reliance on these Resolutions).


  

	5.	Any person, corporation or other legal entity dealing with the Bank may rely upon a certificate signed by an officer of the Bank to effect that these Resolutions and
any agreement, instrument or document executed pursuant to them are still in full force and effect and binding upon the Corporation. 

  

	6.	The Bank may consider the holders of the offices of the Corporation and their signatures, respectively, to be and continue to be as set forth in the Certificate of the
Secretary of the Corporation until notice to the contrary in writing is duly served on the Bank. 

 I further
certify that the above Resolutions are in full force and effect as of the date of this Certificate; that these Resolutions and any borrowings or financial accommodations under these Resolutions have been properly noted in the corporate books and
records, and have not been rescinded, annulled, revoked or modified; that neither the foregoing Resolutions nor any actions to be taken pursuant to them are or will be in contravention of any provision of the articles of incorporation or bylaws of
the Corporation or of any agreement, indenture or other instrument to which the Corporation is a party or by which it is bound; and that neither the articles of incorporation nor bylaws of the Corporation nor any agreement, indenture or other
instrument to which the Corporation is a party or by which it is bound require the vote or consent of shareholders of the Corporation to authorize any act, matter or thing described in the foregoing Resolutions. 

I further certify that the following named persons have been duly elected to the offices set opposite their respective names, that they continue to hold
these offices at the present time, and that the signatures which appear below are the genuine, original signatures of each respectively: 
 (PLEASE SUPPLY GENUINE SIGNATURES OF AUTHORIZED SIGNERS BELOW) 

  
 1 









					
	NAME (Type or Print)	  	TITLE	  	SIGNATURE
			
	  
	  	  
	  	  

			
	  
	  	  
	  	  

			
	  
	  	  
	  	  

			
	  
	  	  
	  	  

			
	  
	  	  
	  	  

			
	  
	  	  
	  	  

			
	  
	  	  
	  	  


 In Witness Whereof, I have affixed my name as Secretary and
have caused the corporate seal (where available) of said Corporation to be affixed on
.                                       
      

	
	
	
	Secretary


 *** 
  

			
	 The Above Statements are Correct.
	 	
		 	SIGNATURE OF OFFICER OR DIRECTOR OR, IF NONE. A SHAREHOLDER OTHER THAN SECRETARY WHEN SECRETARY IS AUTHORIZED TO SIGN ALONE.

 Failure to complete the above when the Secretary is authorized to sign alone shall constitute a certification by the
Secretary that the Secretary is the sole Shareholder, Director and Officer of the Corporation. 

  
 2 








 COMERICA BANK 
 Member FDIC 
 ITEMIZATION OF AMOUNT FINANCED 

DISBURSEMENT INSTRUCTIONS 
 (Growth Capital) 
  

			
	 Name(s): diaDexus, Inc.
	  	Date: September 23, 2011
		
	 $5,000,000
	  	credited to deposit account No. ___________ when Growth Capital Advances are requested or disbursed to Borrower by cashiers check or wire transfer
	
	 Amounts paid to others on your behalf:

		
	 $
	  	to Comerica Bank for Loan Fee
		
	 $
	  	to Comerica Bank for Document Fee
		
	 $
	  	to Comerica Bank for accounts receivable audit (estimate)
		
	 $
	  	to Bank counsel fees and expenses
		
	 $
	  	to _______________
		
	 $
	  	to _______________
		
	 $
	  	TOTAL (AMOUNT FINANCED)

 Upon consummation of this transaction, this document will also serve as the authorization for Comerica Bank to disburse
the loan proceeds as stated above. 
  

			
	  
	  	  

	 Signature
	  	Signature


  
 1 








 



 
 Agreement to Furnish Insurance to Loan and Security Agreement 

 
 (Herein called “Bank”) 

Borrower(s): diaDexus, Inc. 
 I understand that
the Security Agreement or Deed of Trust which I executed in connection with this transaction requires me to provide a physical damage insurance policy including a Lenders Loss Payable Endorsement in favor of the Bank as shown below, within ten
(10) days from the date of this agreement. 
 The following minimum insurance must be provided according to the terms of the security
documents. 
  

											
	 ̈	 	AUTOMOBILES, TRUCKS, RECREATIONAL VEHICLES	  	 	x	  	 	MACHINERY & EQUIPMENT: MISCELLANEOUS PERSONAL PROPERTY
		 	 Comprehensive & Collision
	  				 	 Fire & Extended Coverage

		 	 Lender’s Loss Payable Endorsement
	  				 	 Lender’s Loss Payable Endorsement

		 		  				 	  ̈    Breach of Warranty Endorsement

				
	 ̈	 	BOATS	  	 	 ̈	  	 	AIRCRAFT
		 	 All Risk Hull Insurance
	  				 	 All Risk Ground & Flight Insurance

		 	 Lender’s Loss Payable Endorsement
	  				 	 Lender’s Loss Payable Endorsement

		 	  ̈    Breach of Warranty Endorsement
	  				 	  ̈    Breach of Warranty Endorsement

				
	 ̈	 	MOBILE HOMES	  	 	 ̈	  	 	REAL PROPERTY
		 	 Fire, Theft & Combined Additional Coverage
	  				 	 Fire & Extended Coverage

		 	 Lender’s Loss Payable Endorsement
	  				 	 Lender’s Loss Payable Endorsement

		 	  ̈    Earthquake
	  				 	  ̈     All Risk Coverage

		 		  				 	  ̈    Special Form Risk Coverage

		 		  				 	  ̈    

	x	 	 INVENTORY
	  				 	  ̈    Earthquake

 ̈    Other         
                                         
                         

	 ̈	 	 Other
	 	 	  	 	 	 	 	 
		 		 	 	  	 	 	 	 	 
		 		 	 	  	 	 	 	 	 

 I may obtain the required insurance from any company that is acceptable to the Bank, and will deliver proof of such
coverage with an effective date of September 23, 2011 or earlier. 
 I understand and agree that if I fail to deliver proof of insurance to
the Bank at the address below, or upon the lapse or cancellation of such insurance, the Bank may procure Lender’s Single Interest Insurance or other similar coverage on the property. If the Bank procures insurance to protect its interest in the
property described in the security documents, the cost for the insurance will be added to my indebtedness as provided in the security documents. Lender’s Single Interest Insurance shall cover only the Bank’s interest as a secured party,
and shall become effective at the earlier of the funding date of this transaction or the date my insurance was canceled or expired. I UNDERSTAND THAT LENDER’S SINGLE INTEREST INSURANCE WILL PROVIDE ME WITH ONLY LIMITED PROTECTION AGAINST
PHYSICAL DAMAGE TO THE COLLATERAL, UP TO THE BALANCE OF THE LOAN, HOWEVER, MY EQUITY IN THE PROPERTY WILL NOT BE INSURED. FURTHER, THE INSURANCE WILL NOT PROVIDE MINIMUM PUBLIC LIABILITY OR PROPERTY DAMAGE INDEMNIFICATION AND DOES NOT MEET THE
REQUIREMENTS OF THE FINANCIAL RESPONSIBILITY LAW. 
 CALIFORNIA CIVIL CODE SECTION 2955.5. HAZARD INSURANCE DISCLOSURE: No lender shall require
a borrower, as a condition of receiving or maintaining a loan secured by real property, to provide hazard insurance coverage against risks to the improvements on that real property in an amount exceeding the replacement value of the improvements on
the property. 
  

							
	 	 	Bank Address for Insurance Documents:	  	 
	 			 
	 	 	 	 	 Comerica Bank – Collateral Operations, Mail Code 6514
	  	 
	 	 	 	 	 1508 W. Mockingbird Lane
	  	 
	 	 	 	 	 Dallas, Texas 75235
	  	 
	 	 	 	 	 	  	 


  
 39 









 I acknowledge having read the provisions of this agreement, and agree to its terms. I authorize the Bank to
provide to any person (including any insurance agent or company) any information necessary to obtain the insurance coverage required. 
  

					
	OWNER(S) OF COLLATERAL:	 		 	DATED: September 23, 2011
			
	  
	 		 	  

			
	  
	 		 	  


  

    INSURANCE VERIFICATION 
  

							
				
	    Date	 	 	 	Phone	 	 
	    Agents Name	 	 	 	Person Talked To	 	 


			
	     Agents Address
	 	 


			
	     Insurance Company
	 	 

 
			
	     Policy Number(s)
	 	 


 
							
	     Effective Dates: From
	 	 	 	To:	 	 



							
	     Deductible $
	 	 	 	Comments:	 	 
		 		 		 	

 

  
 2 








      COMERICA BANK 
 AUTOMATIC DEBIT AUTHORIZATION

     Member FDIC 


 
 To: Comerica Bank 
 Re: Loan # ___________________________________ 

You are hereby authorized and instructed to charge account No. _________________________ in the name of diaDexus, Inc. 

 
 for principal, interest and other payments due on
above referenced loan as set forth below and credit the loan referenced above. 

X                Debit each interest payment as it
becomes due according to the terms of the Loan and 
 Security Agreement and any renewals or amendments thereof. 

X                Debit each principal payment as it
becomes due according to the terms of the Loan and 
 Security Agreement and any renewals or amendments thereof. 

X                Debit each payment for Bank Expenses as
it becomes due according to the terms of the Loan and 
 Security Agreement and any renewals or amendments thereof. 

This Authorization is to remain in full force and effect until revoked in writing. 


 

			
	
                Borrower Signature
	  	
Date
  

	 	  	
September 23, 2011                    

  

	 	  	 September 23, 2011

 









 USA PATRIOT ACT 

NOTICE 

OF 

CUSTOMER IDENTIFICATION 
 IMPORTANT INFORMATION ABOUT PROCEDURES FOR OPENING A NEW ACCOUNT 
 To help the
government fight the funding of terrorism and money laundering activities, Federal law requires all financial institutions to obtain, verify, and record information that identifies each person who opens an account. 

WHAT THIS MEANS FOR YOU: when you open an account, we will ask your name, address, date of birth, and other information that will allow
us to identify you. We may also ask to see your driver’s license or other identifying documents. 

  
 2 









			
	DEBTOR	  	diaDexus, Inc.  

	SECURED PARTY:	  	COMERICA BANK

 EXHIBIT A to UCC Financing Statement 

COLLATERAL DESCRIPTION ATTACHMENT TO UCC NATIONAL FINANCING FORM 
 All personal property of Borrower (herein referred to as “Borrower” or “Debtor”) whether presently existing or hereafter created or acquired, and wherever located, including, but not
limited to: 
 All personal property of Debtor of every kind, whether presently existing or hereafter created or acquired, and
wherever located, including but not limited to: (a) all accounts (including health-care-insurance receivables), chattel paper (including tangible and electronic chattel paper), deposit accounts, documents (including negotiable documents),
equipment (including all accessions and additions thereto), general intangibles (including payment intangibles and software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease
or to be furnished under a contract of service, and including returns and repossessions), investment property (including securities and securities entitlements), letter of credit rights, money, and all of Debtor’s books and records with respect
to any of the foregoing, and the computers and equipment containing said books and records; and (b) any and all cash proceeds and/or noncash proceeds thereof, including, without limitation, insurance proceeds, and all supporting obligations and
the security therefor or for any right to payment. All terms above have the meanings given to them in the California Uniform Commercial Code, as amended or supplemented from time to time. 

Notwithstanding the foregoing, the Collateral shall not include (x) any copyrights, patents, trademarks, trade names, trade secrets,
service marks, domain names and registrations, applications, renewals and extensions therefor, now owned or hereafter acquired, or other proprietary rights in technology, or any claims for damages by way of any past, present and future infringement
of any of the foregoing (collectively, the “Intellectual Property”); provided, however, that the Collateral shall include all accounts and general intangibles that consist of rights to payment from the sale, licensing or disposition of all
or any part of, or rights in, the Intellectual Property (the “Rights to Payment”); or (y) any property (i) which is nonassignable by its terms without the consent of the licensor thereof or another party (but only to the extent
such prohibition on transfer is enforceable under applicable law, including, without limitation, Sections 9406 and 9408 of the Code), or (ii) to the extent the granting of a security interest therein is contrary to applicable law, provided that
upon the cessation of any such restriction or prohibition, such property shall automatically become part of the Collateral. Notwithstanding the foregoing, if a judicial authority (including a U.S. Bankruptcy Court) holds that a security interest in
the underlying Intellectual Property is necessary to have a security interest in the Rights to Payment, then the Collateral shall automatically, and effective as of September 23, 2011, include the Intellectual Property to the extent necessary
to permit perfection of Bank’s security interest in the Rights to Payment.