Foramsulfuron Registration Review Scoping Document

Page 3 of 15 residential and occupational handlers. Post

- application exposure is possible for those who re

enter treated areas, including incidental oral (hand

- to

- mouth) and dermal post

- application exposures for toddlers playing on treated turf. There are no risk concerns associated with these exposures, based on the lack of adverse effects in the toxicity database.

The only data gap for human health risk assessment is the required immunotoxicity study, which

should be submitted to support registration review.

Introduction

The Health Effects Division Foramsulfuron Registration Review Team has evaluated the

database and the most recent human health risk assessment for the sulfonylurea herbicide

foramsulfuron to determine if sufficient data are available, and if further updates are needed to support registration review. HED performed this evaluation in order to determine the scope of work necessary to eva luate the current tolerance exemption and existing registrations. The primary source of information for this evaluation was the most recent human health risk assessment ( D324201, K. J. Bailey, 12/20/2006 ) for foramsulfuron

. In performing th is risk

assessment , HED considered the latest Agency science polic ies and risk assessment methodologies

.

F oramsulfuron is a sulfonylurea class herbicide

. The structure of foramsulfuron

, as well as its

chemical names and other identifiers can be found in th e chemical identity table attached to this

document (Attachment 1)

.

Hazard Identification/ Toxicology

The toxicology database for foramsulfuron is complete except for the neurotoxicity battery and the immunotoxicity study that is required in accordance with the 2007 revised 40CFR Part 158 Toxicology Data requirements. However, HED’s Hazard and Science Policy Council (HASPOC) determined that the neurotoxicity battery are not required based on the following weight of

evidence considerations: 1) the lack of neurotoxicity in the available toxicology studies for

foramsulfuron ; 2) the lack of systemic toxicity in the entire toxicology database; and 3) the low concern for neurotoxicity in other members of this class of chemicals ( i.e ., sulfonylureas) for

which e vidence for neurotoxicity among this group occurred at high doses or near the limit dose ( 1

, 000 mg/kg/day )

. OPP is conducting an independent retrospective analysis of 160 immunotoxicity studies submitted to Agency. Preliminary findings of OPP’s retrosp ective analysis suggest that immunotoxicity studies have not yet provided lower p o ints of departure (PoDs) than are selected from other guideline experimental toxicology studies and thus, so far, immunotoxicity studies would not have impacted the Agency’s risk assessments. The OPP retrospective analysis is anticipated to be completed in 2012. In the interim, HED recommends that the immunotoxicity study continue to be required for registration and registration review

chemicals.

In the available toxicology studies for foramsulfuron, there was no evidence of toxicity observed up to the limit dose (≥1000 mg/kg/day) in the majority of the studies and up to the highest dos e tested (500 mg/kg/day) in the developmental rabbit study. Therefore, there is no concer n forForamsulfuron Registration Review Scoping Document

Page 4 of 15 adverse effects following subchronic/chronic exposure to foramsulfuron, or concern for increased susceptibility following in utero or post

- natal exposure. Additionally, there was no sign of mutagenicity, and no evidence of carcinogenicity in studies with rats or mice.

Acute lethality studies conducted with foramsulfuron indicated that it has low toxicity via the oral, dermal, and inhalation routes of exposure (Categories III or IV ). It is mildly irritating to the

eyes (Category IV) and not a dermal irritant or sensitizer.

In the most recent human health risk assessment for foramsulfuron D324201, K. Bailey,

12/20/2006 , no endpoints were selected for risk assessment due to the absence of toxicity in the available toxicology database.

Conclusions for Hazard Identification/Toxicology

The toxicology database for foramsulfuron is mostly complete. However, an immunotoxicity study is not available and should be submitted during registration review

.

Dietary Exposure

The toxicological pr ofile of foramsulfuron supports a tolerance exemption, since no adverse effects were observed in the submitted toxicological studies regardless of the route of exposure. A tolerance exemption was previously established under 40 CFR § 180.1219 for use on field corn, popcorn, and sweet corn

. D ietary exposure assessments are not needed for HED to conclude with reasonable certainty that there is no risk associated with dietary exposure to foramsulfuron through food and drinking water

.

Based on t he very low toxicity of f oramsulfuron described above, HED concurs with the previous decision that dietary expo sure assessments are not needed, and that there is a reasonable certainty that no harm will result to the general population, to infants and chil dren or any other population subgroup from dietary exposure.

Residential Exposure

Foramsulfuron is registered for controlling broadleaf weeds in lawns and other turf areas in residential settings. Even though both registered residential products are intended for professional and commercial applicators, homeowners may purchase and use these products on

residential lawns

, resulting in the potential for residential handler exposure. A quantitative handler exposure assessment was not conducted due to the absence of endpoints and doses for residential dermal and inhalation routes of exposure. HED does not expect to conduct a handler

exposure assessment during registration review for the same reasons

.

Post

- application exposures are expected for adults and children following use of foramsulfuron

on residential sites. These exposures include dermal exposures for adults and children, and incidental oral ( i.e., hand

- to

- mouth , objects

- to

- mouth, and soil ingestion ) exposure for children. However, ther e is no risk associated with these exposures due to the lack of toxicity; no quantitative exposure assessment has been conducted for post

- application exposure. In conjunction with the 2007 Part 158 Data Requirements, HED typically requires submission of aForamsulfuron Registration Review Scoping Document

Page 5 of 15 turf transferable residue (TTR) study to determine exposure and risk associated with toddlers playing on treated turf. However, HED has concluded the study is not needed, since there is no toxicity associated with the relevant routes of exposure to foram sulfuron (i.e., dermal and incidental oral, or hand

- to

- mouth).

Conclusions for Residential Exposure and Risk

There are no residential handler and/or post

- application risks associated with residential uses of foramsulfuron, based on the lack of toxicity o bserved for incidental oral, dermal and inhalation

route and duration of exposure.

Aggregate Risk Assessment

A tolerance exemption w as granted for foramsulfuron due to no adverse effects being observed in the submitted toxicological studies

, regardless of the route of exposure . No quantitative dietary (food and water) or residential exposure assessments were conducted, and there are no risks of concern for these exposure pathways. Aggregate risk is determined from the combined exposure from dietary and residential sources and relevant endpoints for risk assessment. In the case of foramsulfuron, aggregate exposure is not of concern based on the lack of toxicity for any exposure route or duration.

Occupational Exposure

Due to the lack of toxicity endpoints and doses, no quantitative occupational exposure assessments were conducted for the registered uses of foramsulfuron.

Occupational Handler Exposure

Field corn, sweet corn, and popcorn are the only agricultural crops where foramsulfuron

herbicide is used. T he label specified personal protective equipment ( PPE ) consists of a l ong

sleeved shirt, long pants

, shoes with socks

, and gloves , and is expected to provide adequate protection during mixing, loading, and applying the registered formulations of foramsulfuron to

corn. Non

- agricultural uses of foramsulfuron result in exposures to professional and commercial applicators while they treat turf in residential, commercial, industrial, and public areas for weed

control. No quantitative exposure and risk estimates conducted based on the lack of toxicity, and there are no risks of concern for occupational handlers.

Occupational Post

- application Exposure

Registered uses of foramsulfuron on field corn , sweet corn and popco rn result in exposures to workers when they re

- enter treated fields to conduct crop related post

- application activities such as irrigation, weeding, scouting, harvesting, etc.. There are no routine post

- application activities performed on non

- agricultural sites after applying foramsulfuron. The re are no risks associated with occupational post

- application dermal and inhalation exposure, due t o the lack of toxicity for the relevant exposure routes and durations. The registered labels specify a restricted entry interval (REI) of 12 hours, based on the acute toxicity of the technical material. However, HEDForamsulfuron Registration Review Scoping Document

Page 6 of 15 notes that in accordance with the crite ria described in PR Notice 95

- 3, foramsulfuron may be eligible for reduction of the REI to 4 hours, via notification.

Conclusions for Occupational Exposure and Risk

There are on o ccupational handler and post

- application risk s associated with agricultural and

non

- agricultural uses of foramsulfuron , based on the lack of toxicity observed in the hazard database for any relevant route or duration of exposure. Due to the low toxicity of foramsulfuron, wearing the label specified PPE is expected to provide ade quate protection f o r handlers. Post

- application exposures also are not of concern ; workers may re

- enter treated area s after the R estricted E ntry Interval (REI) of 12 hours. HED notes that foramsulfuron may meet

the criteria for reduction of the REI from 12 hours to 4 hours, in accordance with PR Notice 95

- 3.

Public Health and Pesticide Epidemiology Data

HED used OPP’s Incident Data System (IDS) to determine the number and severity of incidents

that resulted from f

oramsulfuron exposure. IDS records incidents resulting in high er severity outcomes in more detail, in a module called the Main IDS module . This system stores incident data for death, major and moderate incidents, and it includes more details about the location, date

and nature of the incident. Main IDS incidents involving only one pesticide are considered to provide more certain information about the potential effects of exposure from the pesticide. The

less severe human incidents (minor, unknown, or no effects outcomes) are r eported by registrants

as counts called aggregate summaries and are recorded in a separate module called Aggregate

IDS

.

In A ggregate IDS , from January 1, 200 7 to June 13, 2012, there were 3 reported incident s involving foramsulfuron

. For the M ain IDS, from January 1, 200 7 to June 13, 2012, there were 2 incidents reported for single chemical only in the database and 1 additional incident reported involving more than one chemical. These incidents were classified as moderate severity. Overall, there are few incidents involving foramsulfuron reported to IDS.

Foramsulfuron is not included in the Agricultural Health Study ( AHS ) , and therefore this study does not provide information for this report.

Based on the low frequency of incident cases reported for foramsulfuron

, there does not appear to be a concern at this time that would warrant further investigation

. The Agency will continue to monitor the incident information and if a concern is triggered, additional analysis will be

included in t he risk assessment.

Tolerance Assessment and International Harmonization

A t olerance exemption was granted for residues of foramsulfuron i n or on field corn, popcorn

and sweet corn ( 40 CFR § 180.1219 )

.Foramsulfuron Registration Review Scoping Document

Page 7 of 15 The Codex Alimentarius Commission (Codex) ha s not established maximum residue limits ( MRLs ) for f

oramsulfuron

. Canada has established an MRL of 0. 0 1 ppm for field corn. M exico adopts U.S. tolerances and/or Codex MRLs for its export purposes. As there are no Codex

MRLs for foramsulfuron , Mexico’s MRLs a re equivalent to the U.S. tolerances.

The international residue limit status sheet can be found in Attachment 4

.

Environmental Justice

Potential areas of environmental justice concerns, to the extent possible, were considered in the human health risk assessment, in accordance with U.S. Executive Order 12898, "Federal Actions to Address Environmental Justice in Minority Populations and Low

- Income Populations," http://www.eh.doe.gov/nepa/tools/guidance/Volume1/2

- 6

- EO_12898envjustice.pdf ). The Office of Pesticide Programs (OPP) typically considers the highest potential exposures from the legal use of a pesticide when conducting human health risk assessments, including, but not limited to, people who obtain drinking water from sources near agricultural areas, the variability of diets within the U.S., and people who may be exposed when harvesting crops. Should these highest exposures indicate potential risks of concern, OPP further refines the risk assessments to ensure

that the risk estimates are based on the best available information.

Endocrine Disrup tor Screening Program

As required by FIFRA and FFDCA, EPA reviews numerous studies to assess potential adverse outcomes from exposure to chemicals. Collectively, these studies include acute, subchronic and chronic toxicity, including assessments of carc inogenicity, neurotoxicity, developmental, reproductive, and general or systemic toxicity. These studies include endpoints which may be susceptible to endocrine influence, including effects on endocrine target organ histopathology, organ weights, estrus cy clicity, sexual maturation, fertility, pregnancy rates, reproductive loss, and sex ratios in offspring. For ecological hazard assessments, EPA evaluates acute tests and chronic studies that assess growth, developmental and reproductive effects in differen t taxonomic groups. As part of its most recent registration decision, EPA reviewed these data and selected the most sensitive endpoints for relevant risk assessment scenarios from the existing hazard database. However, as required by FFDCA section 408(p)

, foramsulfuron is subject to the endocrine screening part of the Endocrine Disruptor Screening Program (EDSP).

EPA has developed the EDSP to determine whether certain substances (including pesticide active and other ingredients) may have an effect in hu mans or wildlife similar to an effect produced by a “naturally occurring estrogen, or other such endocrine effects as the Administrator may designate.” The EDSP employs a two

- tiered approach to making the statutorily required

determinations. Tier 1 consis ts of a battery of 11 screening assays to identify the potential of a chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal systems. Chemicals that go through Tier 1 screening and are found to have the potential to

i nteract with E, A, or T hormonal systems will proceed to the next stage of the EDSP where EPA will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2 testing is designed to identify any adverse endocrine

- related effects caused by the substance, and

establish a dose

- response relationship between the dose and the E, A, or T effect.Foramsulfuron Registration Review Scoping Document

Page 8 of 15 Under FFDCA section 408(p), the Agency must screen all pesticide chemicals. Between October 2009 and February 2010, EPA issued test or ders/data call

- ins for the first group of 67 chemicals, which contains 58 pesticide active ingredients and 9 inert ingredients. Foramsulfuron is not among the group of 58 pesticide active ingredients on the initial list to be screened under

the EDSP. Acc ordingly, as part of registration review, EPA will issue future EDSP orders/data

call

- ins, requiring the submission of EDSP screening assays for foramsulfuron . For further information on the status of the EDSP, the policies and procedures, the list of 67 chemicals, future lists, the test guidelines and the Tier 1 screening battery, please visit our website: http://www.epa.gov/endo/.

Cumulative Risk Assessments

Unlike other pesticides for which EPA has followed a cumulative risk approach based on a

comm on mechanism of toxicity, EPA has not made a common mechanism of toxicity finding as

to f oramsulfuron and any other substances

, and f oramsulfuron does not appear to produce a toxic metabolite produced by other substances. For the purposes of this action, therefore, EPA has not

assumed that f

oramsulfuron has a common mechanism of toxicity with other substances. For information regarding EPA’s efforts to determine which chemicals have a common mechanism of toxicity and to e valuate the cumulative effects of such chemicals, see the policy statements released by EPA’s Office of Pesticide Programs concerning common mechanism determinations and procedures for cumulating effects from substances found to have a common mechanism on

EPA’s website at http://www.epa.gov/pesticides/cumulative/

.

Human Studies

HED risk assessment s for the herbicide foramsulfuron do not rely on data from studies in which adult human subjects were int entionally exposed to a pesticide to determine their dermal and inhalation exposure , since quantitative exposure assessments were not conducted

.

Data Requirements

Only one study is required to support human health risk assessment during registration revi ew:

Toxicology : Guideline No. 870.7800, Immunotoxicity study in mice and/or rats

.

R eferences

Author Barcode Date Title Kristin Rury NA 8 / 8 /12 Foramsulfuron : Summary of Hazard and Science Policy Council (HASPOC) Meeting on July 19th, 2012: Recommendations on data requirements for immunotoxicity, acute and subchronic neurotoxicity, and subchronic

inhalation studies.

S. Recore D403611 7/19/12 Foramsulfuron: Review of Human IncidentsForamsulfuron Registration Review Scoping Document

Page 9 of 15 Author Barcode Date Title K. Bailey D324210 12/20/06 Foramsulfuron: Human Health Risk Assessment for the Proposed use in/on Sweet corn and Popcorn. Petition

5E7004.

M. Corbin D324203 09/21/06 Ecological Risk Assessment and Drinking Water Assessment for the Proposed Addition of Sweet Corn and Popcorn to the Option Label Use of Foramsulfuron on Corn.

Y. Donovan D267582 03/05/02 Evaluation of Residue Chemistry Data to Support Tolerances

for Use of Foramsulfuron on Field Corn.

Y. Donovan D273636 02/26/02 FQPA Human Health Risk Assessment for the Use of

Foramsulfuron on Corn. A. Levy HED

D oc

. N o 014671 09/19/01 Foramsulfuron: Report of the Hazard Identification

Assessment Review Committee.

Attachment s

Attachment 1

. Chemical Identity Table

Attachment 2

. Toxicity Profile for Foramsulfuron

Attachment 3. Foramsulfuron Registered Products and Use Patterns

. Attachment 4

. Intern a tional Residue Limit StatusForamsulfuron Registration Review Scoping Document

Page 10 of 15 Attachment 1

. Chemical Identity Table

Nomenclature

. Chemical structure

Empirical Formula C 17 H 20 N 6 O 7 S

Common name Foramsulf uron Company experimental name AE F130360

IUPAC name 1

- (4,6

- dimethoxypyrimidin

- 2

- yl)

- 3

- [2

- (dimethylcarbamoyl)

- 5

- formamidophenylsulfonyl]urea

CAS name 2

- [[[[(4,6

- dimethoxy

- 2

- pyrimidinyl)amino]carbonyl]amino]sulfonyl]

- 4

- (formylamino)

- N,N

- dimethylbenzamide

CAS registry number 173159

- 57

- 4

End

- use product (EP) Revolver Herbicide, Tribute WG Herbicide , Tribute Solo WG32 Herbicide, Option Corn Herbicide

Chemical Class Pyrimidinyl sulfonylurea herbicide Molecular Weight: 452.49

Known Impurities of Concern None of concern

Chemical Characteristics Property Technical End

- use Physical State Powder Fine grained granule

Color Light beige Yellowish

- brown

Odor Slightly acidulous Weakly aromatic Melting Point 202°C N/A Density 1.44 g/cm 3 @ 20°C 0.56 g/mL @ 20°C Solubility (Water) 3290 mg/L @ 20°C and pH 7 N/A Vapor Pressure 4.2 X 10

- 11 Pa @ 20 0 C. N/A

Octanol/Water Partition

Coefficient K ow = 4.01 (in unbuffered distilled water @ pH 5.5

- 5.7) N/A

pH 4.5 (1% dilution in distilled water) 6.7 (1% dilution in distilled water)Foramsulfuron Registration Review Scoping Document

Page 11 of 15 Attachment 2

. Toxicity Profile for Foramsulfuron

.

Acute Toxicity (technical grade active ingredient)

Guideline

No. Study Type MRID NO. Results Toxicity Category

81

- 1 Acute Oral 45109433 LD 50 > 5000 mg/kg IV

81

- 2 Acute Dermal 45109434 LD 50 > 2000 mg/kg III

81

- 3 Acute Inhalation 45109435 LC 50 > 5.04 mg/L IV

81

- 4 Primary Eye Irritation 45109437 Mild eye irritant IV

81

- 5 Primary Skin Irritation 45109436 Not a dermal irritant IV

81

- 6 Dermal Sensitization 45109438 Not a dermal sensitizer N/A

Subchronic, Chronic, and Other Toxicity

Guideline No./ Study Type MRID No. (year)/

Classification/Doses Results

870.3100

90

- Day oral toxicity

- mouse MRID 45109605

- 1998 (90 day); MRID 45109602 (28 day)

ppm=0, 64, 3200, 6400

mg/kg/day (M/F): 0/0, 10.5/14.6,
498/822, 1002/1178 NOAEL = 1002/1178 mg/kg/day (M/F)

LOAEL=not determined

870.3100

90

- Day oral toxicity

- rat MRID 45109604 (1998)

ppm=0, 20, 200, 5000, 20000

mg/kg/day (M/F): 0/0, 1.54/1.81,
15.4/19.4, 388/475, 1568/1786 NOAEL = 1568/1786 mg/kg/day (M/F)

LOAEL=not determined

870.3150

90

- Day oral toxicity

- dog MRID 45109606 (1998)

mg/kg/day (M/F): 0, 10, 250, 1000 NOAEL = 1000 mg/kg/day

LOAEL=not determined

870.3200

28

- Day dermal toxicity

- rat MRID 45109608

mg/kg/day (M/F): 0, 10, 100, 1000 NOAEL = 1000 mg/kg/day

LOAEL=not determined

28

- Day inhalation toxicity

- rat Waived by HASPOC

870.3700a

Prenatal developmental

- rat MRID 45109617

mg/kg/day (M/F): 0, 5, 71, 1000 Maternal and Developmental NOAEL = 1000 mg/kg/day

LOAEL=not determinedForamsulfuron Registration Review Scoping Document

Page 12 of 15 Guideline No./ Study Type MRID No. (year)/

Classification/Doses Results

870.3700b

Prenatal developmental

- rabbit MRID 45109608 (1997)

mg/kg/day (M/F): 0, 5, 50, 500 Maternal and Developmental NOAEL = 500 mg/kg/day

LOAEL=not determined

870.3800

Reproduction and fertility

effects

- rat MRID 45109616 (1999)

ppm=0, 100, 1225, 15000

mg/kg/day (M/F)=0/0, 7/8, 85/99,

1082/1229 Parental/Systemic, Reproductive and Offspring

NOAEL = 1082/1229

Parental/Systemic, Reproductive and Offspring

LOAEL=not determined

870.4100a

870.4200

Combined Chronic/ Carcinogenicity

- rat MRID 45109614 (2000)

ppm=0, 100, 600, 6000, 20000

mg/kg/day (M/F)=0/0, 4.5/5.6,
25/35, 246/339, 849/1135 NOAEL = 849/1135 mg/kg/day

LOAEL=not determined

no evidence of carcinogenicity

870.4100b

Chronic toxicity

- dog MRID 45109607 (1999)

mg/kg/day (M/F): 0, 5, 100, 1000 NOAEL = 1000 mg/kg/day, HDT

LOAEL=not determined

870.4300

Carcinogenicity

- mouse MRID 45109608 (1997)

ppm=0, 40, 800, 8000

mg/kg/day (M/F): 0/0, 5.4/6.5, 108.9/ 133.7, 1115.1/1357.5 NOAEL = 1115/1357 mg/kg/day (M/F) mg/kg/day (M/F)= 0/0, 5.4/ 6.5, 108.9/133.7,

1115.1/1357.5

LOAEL=not determined

no evidence of carcinogenicity

870.5100

Bacterial Reverse Mutation

Test MRID 45109609

0.032,0.16,0.8,4,20 100, 500, 2500, or 5000 /ug/plate (Salmonella strains) and 4, 20, 100, 500, 2500, or 5000 ug/p1ate (E. coli strain) Negative

870.5300

Mammalian Cell Forward

Gene Mutation MRID 45109611

ug/ml= 250, 500, 1000, 2000 Negative

870.5375

In Vitro Mammalian Cell

chromosome Aberration Assay MRID 45109610 ug/ml=18.8

- 2400 Negative

870.5395

Bone Marrow Micronucleus MRID 45109612

mg/kg/day= 200, 1000, 2000 Negative

870.5550

Unscheduled DNA synthesis MRID 45109613

mg/kg/day=600 or 2000 NegativeForamsulfuron Registration Review Scoping Document

Page 13 of 15 Guideline No./ Study Type MRID No. (year)/

Classification/Doses Results

870.6100 Acute Neurotoxicity Waived by HASPOC

870.6200

Subchronic Neurotoxicity Waived by HASPOC

870.7485

Metabolism and pharmacokinetics MRID 45109427

- 31

Single oral dose at 10 or 1000 mg/kg, or as a repeated oral dose at 10 mg/kg/day for 1, 9, 14 days. Four male, bile duct

- cannulated, rats also received a single ora l dose of [ 14 C

- phenyl] foramsulfuron at 10 mg/kg, and another group of rats (2/sex) received a single oral dose of [ 14 C

pyrimidyl] foramsulfuron at 10 mg/kg. Overall metabolism was similar between the sexes and the various dose groups. For the single low

and high

- dose groups, the majority of the 14 C

- dose was excreted as parent (74.4

- 80.8% dose), most of which was recovered in the feces (72.3

- 80.4% dose). Paren t compound was also the only 14 C

residue found in the feces of repeated dose males (64.3%) and females (98.1%). Other minor

metabolites identified in feces and urine included the cleavage product AE F 153745 (1.6

- 11.0% dose) and the free amine metabolite A E F130619 (0.8

- 3.5% dose). Minor amounts of unknown(s) were also detected in the feces (≤5.9% dose) and urine (≤3.9%).

870.7800 Immunotoxicity Required: Data GapForamsulfuron Registration Review Scoping Document

Page 14 of 15 Attachment 3. Registered F oramsulfuron Products and Use Patterns

Use Patterns of End

- use Product Formulations of Foramsulfuron

. EPA Reg. No. & (Formulation types) % AI Use sites Application method /Comments

264

- 685 (WDG) 35.0 Field, sweet and pop corn Air and ground broadcast spray, 2 applns.

per year . A RTI was not specified

. Maximum application rate is 0.038 lbs ai/A.

264

- 686 (WDG) 30.0 Field corn Ground broadcast spray, one appln./season

. Maximum application rate is 0.028 lbs ai/A.

264

- 688 99.1 Field, sweet and pop corn, golf course turf, sports fields,

commercial lawns, cemeteries, parks, campsites, recreation areas, home lawns, roadsides, school grounds, and sod farms. NA [Technical Active Ingredient]

432

- 1266 (SC) 2.34 (0.19 lbs ai/gal) Commercial and residential turf Ground broadcast and spot treatments; 2 applns. @14

- 21 day interval

. Maximum single application rate is 0.052 lbs ai/A.

432

- 1519 (WDG) 19.8 Commercial and residential turf Ground broadcast and spot treatments; 2 applns. per year @ 14

- 21 day interval

. No interval specified for the spot treatme nt use.

Abbre viations used: AI = active ingredient, NA = not applicable, RTI = re

- treatment interval: SC=soluble concentrate, WDG = water dispersible granule or dry flowable (DF).Foramsulfuron Registration Review Scoping Document

Page 15 of 15 Attachment 4 . International Residue Limit Status



### Foramsulfuron (122020; 07/03/12)

Summary of US and International Tolerances and Maximum Residue Limits Residue Definition : Tolerance exemption

US Canada Mexico 1 Codex

40 CFR 180.1219 Foramsulfuron; exemption from the requirement of a tolerance. 2

- [[[[(4,6

- dimethoxy

- 2

- pyrimidinyl)amino]carbonyl] amino]sulfonyl]

- 4

- (formylamino)

- N,N

- dimethylbenzamide None

Commodity Tolerance (ppm) /Maximum Residue Limit (mg/kg)

US Canada Mexico 1 Codex 2

The pesticide foramsulfuron is exempted from

the requirement of a tolerance in corn, field, grain/corn, field, forage/ corn, field, stover/corn, pop, grain/corn, pop, forage/corn, pop, stover; corn, sweet, forage; corn, sweet, kernel plus cob with husks removed; corn, sweet, stover when applied as a herb icide in accordance with good agricultural practices. MRLs with No US Equivalent

Field Corn 0.01

Completed: M. Negussie; 07/05/2012

1 Mexico adopts US tolerances and/or Codex MRLs for its export purposes.