STRUCTURE ACTIVITY TEAM REPORT 12/09/03 

CASE NUMBER: P04-0141

RELATED CASES: 

CONCLUSIONS/DISCUSSIONS 

TYPE OF CONCERN: HEALTH ECOTOX 

LEVEL OF CONCERN: 2 2 

KEYWORDS: LUNG IRR-E,S,MM,L 

 AQUATOX 

SUMMARY OF ASSESSMENT 

FATE: Solid; ; Estimations for P-140 low MW274 LogKow = -

1.55(E)S = Disp.(ICB); H < 1.00E-8(E) 

MP (C) = 250(E); BP (C) > 400(E); VP @ 25C (mm) < 1.0E-6(E) 

LogKoc = 1.28(E); LogBCF = 0.50(E); 

POTW removal (%) = 139/40: 90 via biodeg; P-139 OECD91.6%/28d; 

OECD 301E(Mod Screening): 71.5%/28d; P140 OECD 301B(Mod Sturm CO2 

Ev): 77.5%/28d RB; 141: 50 via sorption & biodeg; P-141 

BOD5/COD=58.5%; OECD 301E(Mod Screening): 38.9%/28d NRB; OECD: 

60%/28d; River Die Away Test (5d/10d/15d/20d): 35%/59%/79%/90%; 

OECD 301D(Closed Bottle) 2 & 10mg/L: 90.1 & 82.2%/28d. 

Time for complete ultimate aerobic biodeg = wk-mo 

PBT Potential: P1B1T1 

Sorption to soils/sediments = low 

*CEB FATE: Migration to ground water = slow - moderate 

HEALTH: Absorption is nil from the skin, poor from the GI tract, 

and moderate from the lung (analog). Concern for surfactant 

effects on the lung; and irritation to all tissues based on 

submitted test data. 

 *CEB HEALTH: Moderate concern (Dermal, inhalation); XB: NO 

testing 

 Test data: mouse oral LD50 = 7.5 mL/kg (20%ai); slight skin 

irritation in rabbits (16% ai); severe eye irritation in rabbits 

(pH 7, 10% ai); moderate eye irritation in rabbits (16% ai) 

ECOTOX: Predicted (P) and measured (M) toxicity values in mg/L 

(ppm) FOR THE LEAST TOXIC PRODUCT THAT CAN BE MAKE UNDER THE CAS 

NAME (92% WITH WEIGHT AVERAGE are: 

fish 96-h LC50 = 350.0 P 

daphnid 48-h LC50 = 350.0 P 

green algal 96-h EC50 = 350.0 P 

fish chronic value = 40.0 P 

daphnid ChV = 40.0 P 

algal ChV = 90.0 P 
Predictions are based on SAR-nearest analog method for amphoteric 

surfactants-; SAR chemical class = surfactant-amphoteric; 

MW428; pH7; effective concentrations based on 100% active 

ingredients and mean measured concentrations; hardness <150.0 

mg/L as; and TOC <2.0 mg/L; 

low concern for toxicity 

assessment factor = 10.0 

concern concentration = 1.0 mg/L (ppm) 

Predicted (P) and measured (M) toxicity values in mg/L (ppm) FOR 

THE MOST TOXIC PRODUCT THAT CAN BE MAKE UNDER THE CAS NAME (2 

WITH WEIGHT AVERAGE are: 

fish 96-h LC50 = 0.590 P 

daphnid 48-h LC50 = 0.590 P 

green algal 96-h EC50 = 0.590 P 

fish chronic value = 0.060 P 

daphnid ChV = 0.060 P 

algal ChV = 0.150 P 

Predictions are based on SAR-nearest analog method for amphoteric 

surfactants-; SAR chemical class = surfactant-amphoteric-; 

MW504; pH7; effective concentrations based on 100% active 

ingredients and mean measured concentrations; hardness <150.0 

mg/L as; and TOC <2.0 mg/L; 

high concern for toxicity 

assessment factor = 10.0 

concern concentration = 0.006 mg/L (ppm) 

Submitted test data for a product with unknown composition: 

fish (FHM) 96-h LC50 = 2.1 M S,N H270 

daphnid 48-h LC50 = 4.0 M S,N 

fish ChV = 0.200 P FHM/ACR10 

daphnid ChV = 0.400 P D48/ACR10 

The toxicity of this product is intermediate between the worst 

case product the least toxic product. 

*CEB ECOTOX: All releases to water; risk assessment needed for 

both CCs: 6 ppb and 1000 ppb; and XB: Testing desired. 

SAT Co-chair: Leonard Keifer 564-8916