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residential and occupational handlers. Post-application exposure is possible for those who reenter treated areas, including incidental oral (hand-to-mouth) and dermal post-application 

exposures for toddlers playing on treated turf. There are no risk concerns associated with these 

exposures, based on the lack of adverse effects in the toxicity database.

The only data gap for human health risk assessment is the required immunotoxicity study, which 

should be submitted to support registration review.

Introduction

The Health Effects Division Foramsulfuron Registration Review Team has evaluated the 

database and the most recent human health risk assessment for the sulfonylurea herbicide 

foramsulfuron to determine if sufficient data are available, and if further updates are needed to 

support registration review. HED performed this evaluation in order to determine the scope of 

work necessary to evaluate the current tolerance exemption and existing registrations. The 

primary source of information for this evaluation was the most recent human health risk 

assessment (D324201, K. J. Bailey, 12/20/2006) for foramsulfuron. In performing this risk 

assessment, HED considered the latest Agency science policies and risk assessment 

methodologies.

Foramsulfuron is a sulfonylurea class herbicide. The structure of foramsulfuron, as well as its 

chemical names and other identifiers can be found in the chemical identity table attached to this 

document (Attachment 1).

 

Hazard Identification/Toxicology

The toxicology database for foramsulfuron is complete except for the neurotoxicity battery and 

the immunotoxicity study that is required in accordance with the 2007 revised 40CFR Part 158 

Toxicology Data requirements. However, HED’s Hazard and Science Policy Council (HASPOC) 

determined that the neurotoxicity battery are not required based on the following weight of 

evidence considerations: 1) the lack of neurotoxicity in the available toxicology studies for 

foramsulfuron; 2) the lack of systemic toxicity in the entire toxicology database; and 3) the low 

concern for neurotoxicity in other members of this class of chemicals (i.e., sulfonylureas) for 

which evidence for neurotoxicity among this group occurred at high doses or near the limit dose 

(1,000 mg/kg/day). OPP is conducting an independent retrospective analysis of 160 

immunotoxicity studies submitted to Agency. Preliminary findings of OPP’s retrospective 

analysis suggest that immunotoxicity studies have not yet provided lower points of departure

(PoDs) than are selected from other guideline experimental toxicology studies and thus, so far, 

immunotoxicity studies would not have impacted the Agency’s risk assessments. The OPP 

retrospective analysis is anticipated to be completed in 2012. In the interim, HED recommends 

that the immunotoxicity study continue to be required for registration and registration review 

chemicals.

In the available toxicology studies for foramsulfuron, there was no evidence of toxicity observed 

up to the limit dose (≥1000 mg/kg/day) in the majority of the studies and up to the highest dose

tested (500 mg/kg/day) in the developmental rabbit study. Therefore, there is no concern for 
Foramsulfuron Registration Review Scoping Document

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adverse effects following subchronic/chronic exposure to foramsulfuron, or concern for 

increased susceptibility following in utero or post-natal exposure. Additionally, there was no 

sign of mutagenicity, and no evidence of carcinogenicity in studies with rats or mice. 

Acute lethality studies conducted with foramsulfuron indicated that it has low toxicity via the 

oral, dermal, and inhalation routes of exposure (Categories III or IV). It is mildly irritating to the 

eyes (Category IV) and not a dermal irritant or sensitizer.

In the most recent human health risk assessment for foramsulfuron D324201, K. Bailey, 

12/20/2006, no endpoints were selected for risk assessment due to the absence of toxicity in the 

available toxicology database. 

Conclusions for Hazard Identification/Toxicology

The toxicology database for foramsulfuron is mostly complete. However, an immunotoxicity

study is not available and should be submitted during registration review. 

Dietary Exposure

The toxicological profile of foramsulfuron supports a tolerance exemption, since no adverse 

effects were observed in the submitted toxicological studies regardless of the route of exposure. 

A tolerance exemption was previously established under 40 CFR §180.1219 for use on field corn, 

popcorn, and sweet corn. Dietary exposure assessments are not needed for HED to conclude with 

reasonable certainty that there is no risk associated with dietary exposure to foramsulfuron

through food and drinking water.

Based on the very low toxicity of foramsulfuron described above, HED concurs with the 

previous decision that dietary exposure assessments are not needed, and that there is a reasonable 

certainty that no harm will result to the general population, to infants and children or any other 

population subgroup from dietary exposure.

Residential Exposure

Foramsulfuron is registered for controlling broadleaf weeds in lawns and other turf areas in 

residential settings. Even though both registered residential products are intended for 

professional and commercial applicators, homeowners may purchase and use these products on 

residential lawns, resulting in the potential for residential handler exposure. A quantitative 

handler exposure assessment was not conducted due to the absence of endpoints and doses for 

residential dermal and inhalation routes of exposure. HED does not expect to conduct a handler 

exposure assessment during registration review for the same reasons. 

Post-application exposures are expected for adults and children following use of foramsulfuron 

on residential sites. These exposures include dermal exposures for adults and children, and 

incidental oral (i.e., hand-to-mouth, objects-to-mouth, and soil ingestion) exposure for children. 

However, there is no risk associated with these exposures due to the lack of toxicity; no 

quantitative exposure assessment has been conducted for post-application exposure. In 

conjunction with the 2007 Part 158 Data Requirements, HED typically requires submission of a
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turf transferable residue (TTR) study to determine exposure and risk associated with toddlers 

playing on treated turf. However, HED has concluded the study is not needed, since there is no 

toxicity associated with the relevant routes of exposure to foramsulfuron (i.e., dermal and 

incidental oral, or hand-to-mouth).

Conclusions for Residential Exposure and Risk

There are no residential handler and/or post-application risks associated with residential uses of 

foramsulfuron, based on the lack of toxicity observed for incidental oral, dermal and inhalation 

route and duration of exposure. 

Aggregate Risk Assessment

A tolerance exemption was granted for foramsulfuron due to no adverse effects being observed 

in the submitted toxicological studies, regardless of the route of exposure. No quantitative 

dietary (food and water) or residential exposure assessments were conducted, and there are no 

risks of concern for these exposure pathways. Aggregate risk is determined from the combined 

exposure from dietary and residential sources and relevant endpoints for risk assessment. In the 

case of foramsulfuron, aggregate exposure is not of concern based on the lack of toxicity for any 

exposure route or duration.

Occupational Exposure 

Due to the lack of toxicity endpoints and doses, no quantitative occupational exposure 

assessments were conducted for the registered uses of foramsulfuron.

Occupational Handler Exposure

Field corn, sweet corn, and popcorn are the only agricultural crops where foramsulfuron 

herbicide is used. The label specified personal protective equipment (PPE) consists of a longsleeved shirt, long pants, shoes with socks, and gloves, and is expected to provide adequate 

protection during mixing, loading, and applying the registered formulations of foramsulfuron to

corn. Non-agricultural uses of foramsulfuron result in exposures to professional and commercial 

applicators while they treat turf in residential, commercial, industrial, and public areas for weed 

control. No quantitative exposure and risk estimates conducted based on the lack of toxicity, and 

there are no risks of concern for occupational handlers.

Occupational Post-application Exposure

Registered uses of foramsulfuron on field corn, sweet corn and popcorn result in exposures to 

workers when they re-enter treated fields to conduct crop related post-application activities such 

as irrigation, weeding, scouting, harvesting, etc.. There are no routine post-application activities 

performed on non-agricultural sites after applying foramsulfuron. There are no risks associated 

with occupational post-application dermal and inhalation exposure, due to the lack of toxicity for 

the relevant exposure routes and durations. The registered labels specify a restricted entry 

interval (REI) of 12 hours, based on the acute toxicity of the technical material. However, HED 
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notes that in accordance with the criteria described in PR Notice 95-3, foramsulfuron may be 

eligible for reduction of the REI to 4 hours, via notification.

Conclusions for Occupational Exposure and Risk

There are on occupational handler and post-application risks associated with agricultural and 

non-agricultural uses of foramsulfuron, based on the lack of toxicity observed in the hazard 

database for any relevant route or duration of exposure. Due to the low toxicity of 

foramsulfuron, wearing the label specified PPE is expected to provide adequate protection for

handlers. Post-application exposures also are not of concern; workers may re-enter treated areas

after the Restricted Entry Interval (REI) of 12 hours. HED notes that foramsulfuron may meet 

the criteria for reduction of the REI from 12 hours to 4 hours, in accordance with PR Notice 95-

3.

Public Health and Pesticide Epidemiology Data

HED used OPP’s Incident Data System (IDS) to determine the number and severity of incidents 

that resulted from foramsulfuron exposure. IDS records incidents resulting in higher severity

outcomes in more detail, in a module called the Main IDS module. This system stores incident 

data for death, major and moderate incidents, and it includes more details about the location, date 

and nature of the incident. Main IDS incidents involving only one pesticide are considered to 

provide more certain information about the potential effects of exposure from the pesticide. The

less severe human incidents (minor, unknown, or no effects outcomes) are reported by registrants 

as counts called aggregate summaries and are recorded in a separate module called Aggregate 

IDS. 

In Aggregate IDS, from January 1, 2007 to June 13, 2012, there were 3 reported incidents

involving foramsulfuron. For the Main IDS, from January 1, 2007 to June 13, 2012, there were 2 

incidents reported for single chemical only in the database and 1 additional incident reported 

involving more than one chemical. These incidents were classified as moderate severity. 

Overall, there are few incidents involving foramsulfuron reported to IDS. 

Foramsulfuron is not included in the Agricultural Health Study (AHS), and therefore this study 

does not provide information for this report.

Based on the low frequency of incident cases reported for foramsulfuron, there does not appear 

to be a concern at this time that would warrant further investigation. The Agency will continue 

to monitor the incident information and if a concern is triggered, additional analysis will be 

included in the risk assessment.

Tolerance Assessment and International Harmonization

A tolerance exemption was granted for residues of foramsulfuron in or on field corn, popcorn 

and sweet corn (40 CFR §180.1219).
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The Codex Alimentarius Commission (Codex) has not established maximum residue limits 

(MRLs) for foramsulfuron. Canada has established an MRL of 0.01 ppm for field corn. Mexico 

adopts U.S. tolerances and/or Codex MRLs for its export purposes. As there are no Codex 

MRLs for foramsulfuron, Mexico’s MRLs are equivalent to the U.S. tolerances.

The international residue limit status sheet can be found in Attachment 4.

Environmental Justice

Potential areas of environmental justice concerns, to the extent possible, were considered in the 

human health risk assessment, in accordance with U.S. Executive Order 12898, "Federal Actions 

to Address Environmental Justice in Minority Populations and Low-Income Populations," 

http://www.eh.doe.gov/nepa/tools/guidance/Volume1/2-6-EO_12898envjustice.pdf). The Office 

of Pesticide Programs (OPP) typically considers the highest potential exposures from the legal 

use of a pesticide when conducting human health risk assessments, including, but not limited to, 

people who obtain drinking water from sources near agricultural areas, the variability of diets 

within the U.S., and people who may be exposed when harvesting crops. Should these highest 

exposures indicate potential risks of concern, OPP further refines the risk assessments to ensure 

that the risk estimates are based on the best available information.

Endocrine Disruptor Screening Program 

As required by FIFRA and FFDCA, EPA reviews numerous studies to assess potential adverse 

outcomes from exposure to chemicals. Collectively, these studies include acute, subchronic and 

chronic toxicity, including assessments of carcinogenicity, neurotoxicity, developmental, 

reproductive, and general or systemic toxicity. These studies include endpoints which may be 

susceptible to endocrine influence, including effects on endocrine target organ histopathology, 

organ weights, estrus cyclicity, sexual maturation, fertility, pregnancy rates, reproductive loss, 

and sex ratios in offspring. For ecological hazard assessments, EPA evaluates acute tests and 

chronic studies that assess growth, developmental and reproductive effects in different 

taxonomic groups. As part of its most recent registration decision, EPA reviewed these data and 

selected the most sensitive endpoints for relevant risk assessment scenarios from the existing 

hazard database. However, as required by FFDCA section 408(p), foramsulfuron is subject to 

the endocrine screening part of the Endocrine Disruptor Screening Program (EDSP). 

EPA has developed the EDSP to determine whether certain substances (including pesticide 

active and other ingredients) may have an effect in humans or wildlife similar to an effect 

produced by a “naturally occurring estrogen, or other such endocrine effects as the Administrator 

may designate.” The EDSP employs a two-tiered approach to making the statutorily required 

determinations. Tier 1 consists of a battery of 11 screening assays to identify the potential of a 

chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal 

systems. Chemicals that go through Tier 1 screening and are found to have the potential to 

interact with E, A, or T hormonal systems will proceed to the next stage of the EDSP where EPA 

will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2 

testing is designed to identify any adverse endocrine-related effects caused by the substance, and 

establish a dose-response relationship between the dose and the E, A, or T effect. 
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Under FFDCA section 408(p), the Agency must screen all pesticide chemicals. Between 

October 2009 and February 2010, EPA issued test orders/data call-ins for the first group of 67 

chemicals, which contains 58 pesticide active ingredients and 9 inert ingredients. Foramsulfuron

is not among the group of 58 pesticide active ingredients on the initial list to be screened under 

the EDSP. Accordingly, as part of registration review, EPA will issue future EDSP orders/data 

call-ins, requiring the submission of EDSP screening assays for foramsulfuron. For further 

information on the status of the EDSP, the policies and procedures, the list of 67 chemicals, 

future lists, the test guidelines and the Tier 1 screening battery, please visit our website: 

http://www.epa.gov/endo/.

Cumulative Risk Assessments 

Unlike other pesticides for which EPA has followed a cumulative risk approach based on a 

common mechanism of toxicity, EPA has not made a common mechanism of toxicity finding as 

to foramsulfuron and any other substances, and foramsulfuron does not appear to produce a toxic 

metabolite produced by other substances. For the purposes of this action, therefore, EPA has not 

assumed that foramsulfuron has a common mechanism of toxicity with other substances. For 

information regarding EPA’s efforts to determine which chemicals have a common mechanism 

of toxicity and to evaluate the cumulative effects of such chemicals, see the policy statements 

released by EPA’s Office of Pesticide Programs concerning common mechanism determinations 

and procedures for cumulating effects from substances found to have a common mechanism on 

EPA’s website at http://www.epa.gov/pesticides/cumulative/.

Human Studies

HED risk assessments for the herbicide foramsulfuron do not rely on data from studies in which 

adult human subjects were intentionally exposed to a pesticide to determine their dermal and 

inhalation exposure, since quantitative exposure assessments were not conducted.

Data Requirements

Only one study is required to support human health risk assessment during registration review:

Toxicology: Guideline No. 870.7800, Immunotoxicity study in mice and/or rats.

References

Author Barcode Date Title

Kristin Rury NA 8/8/12 Foramsulfuron: Summary of Hazard and Science Policy 

Council (HASPOC) Meeting on July 19th, 2012: 

Recommendations on data requirements for immunotoxicity, 

acute and subchronic neurotoxicity, and subchronic 

inhalation studies.

S. Recore D403611 7/19/12 Foramsulfuron: Review of Human Incidents
Foramsulfuron Registration Review Scoping Document

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Author Barcode Date Title

K. Bailey D324210 12/20/06 Foramsulfuron: Human Health Risk Assessment for the 

Proposed use in/on Sweet corn and Popcorn. Petition 

5E7004. 

M. Corbin D324203 09/21/06 Ecological Risk Assessment and Drinking Water Assessment 

for the Proposed Addition of Sweet Corn and Popcorn to the 

Option Label Use of Foramsulfuron on Corn. 

Y. Donovan D267582 03/05/02 Evaluation of Residue Chemistry Data to Support Tolerances 

for Use of Foramsulfuron on Field Corn. 

Y. Donovan D273636 02/26/02 FQPA Human Health Risk Assessment for the Use of 

Foramsulfuron on Corn.

A. Levy HED 

Doc. No

014671

09/19/01 Foramsulfuron: Report of the Hazard Identification 

Assessment Review Committee.

Attachments

Attachment 1. Chemical Identity Table

Attachment 2. Toxicity Profile for Foramsulfuron

Attachment 3. Foramsulfuron Registered Products and Use Patterns.

Attachment 4. International Residue Limit Status
Foramsulfuron Registration Review Scoping Document

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Attachment 1. Chemical Identity Table

Nomenclature.

Chemical structure

Empirical Formula C17H20N6O7S

Common name Foramsulfuron

Company experimental name AE F130360

IUPAC name 1-(4,6-dimethoxypyrimidin-2-yl)-3-[2-(dimethylcarbamoyl)-5-

formamidophenylsulfonyl]urea

CAS name 2-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-4-

(formylamino)-N,N-dimethylbenzamide

CAS registry number 173159-57-4

End-use product (EP) Revolver Herbicide, Tribute WG Herbicide, Tribute Solo WG32 Herbicide, 

Option Corn Herbicide

Chemical Class Pyrimidinyl sulfonylurea herbicide

Molecular Weight: 452.49

Known Impurities of Concern None of concern

Chemical Characteristics 

Property Technical End-use 

Physical State Powder Fine grained granule 

Color Light beige Yellowish-brown 

Odor Slightly acidulous Weakly aromatic 

Melting Point 202°C N/A 

Density 1.44 g/cm3 @ 20°C 0.56 g/mL @ 20°C 

Solubility (Water) 3290 mg/L @ 20°C and pH 7 N/A 

Vapor Pressure 4.2 X 10-11 Pa @ 20 0C. N/A 

Octanol/Water Partition 

Coefficient 

Kow = 4.01 (in unbuffered distilled 

water @ pH 5.5 - 5.7) N/A 

pH 4.5 (1% dilution in distilled water) 6.7 (1% dilution in distilled water)
Foramsulfuron Registration Review Scoping Document

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Attachment 2. Toxicity Profile for Foramsulfuron.

Acute Toxicity (technical grade active ingredient)

Guideline

No.

Study Type MRID NO. Results Toxicity

Category

81-1 Acute Oral 45109433 LD50 > 5000 mg/kg IV

81-2 Acute Dermal 45109434 LD50 > 2000 mg/kg III

81-3 Acute Inhalation 45109435 LC50 > 5.04 mg/L IV

81-4 Primary Eye Irritation 45109437 Mild eye irritant IV

81-5 Primary Skin Irritation 45109436 Not a dermal irritant IV

81-6 Dermal Sensitization 45109438 Not a dermal sensitizer N/A

Subchronic, Chronic, and Other Toxicity

Guideline No./ Study Type MRID No. (year)/

Classification/Doses

Results

870.3100

90-Day oral toxicity-mouse

MRID 45109605-1998 (90 day); 

MRID 45109602 (28 day)

ppm=0, 64, 3200, 6400

mg/kg/day (M/F): 0/0, 10.5/14.6, 

498/822, 1002/1178

NOAEL = 1002/1178 mg/kg/day (M/F)

LOAEL=not determined

870.3100

90-Day oral toxicity-rat

MRID 45109604 (1998)

ppm=0, 20, 200, 5000, 20000

mg/kg/day (M/F): 0/0, 1.54/1.81, 

15.4/19.4, 388/475, 1568/1786

NOAEL = 1568/1786 mg/kg/day (M/F)

LOAEL=not determined

870.3150

90-Day oral toxicity -dog

MRID 45109606 (1998) 

mg/kg/day (M/F): 0, 10, 250, 1000

NOAEL = 1000 mg/kg/day

LOAEL=not determined

870.3200

28-Day dermal toxicity-rat

MRID 45109608

mg/kg/day (M/F): 0, 10, 100, 1000

NOAEL = 1000 mg/kg/day

LOAEL=not determined

28-Day inhalation toxicity-rat Waived by HASPOC

870.3700a

Prenatal developmental -rat

MRID 45109617

mg/kg/day (M/F): 0, 5, 71, 1000

Maternal and Developmental NOAEL = 1000 

mg/kg/day

LOAEL=not determined
Foramsulfuron Registration Review Scoping Document

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Guideline No./ Study Type MRID No. (year)/

Classification/Doses

Results

870.3700b

Prenatal developmental -rabbit

MRID 45109608 (1997)

mg/kg/day (M/F): 0, 5, 50, 500

Maternal and Developmental NOAEL = 500 

mg/kg/day

LOAEL=not determined

870.3800

Reproduction and fertility 

effects-rat

MRID 45109616 (1999)

ppm=0, 100, 1225, 15000

mg/kg/day (M/F)=0/0, 7/8, 85/99, 

1082/1229

Parental/Systemic, Reproductive and Offspring 

NOAEL = 1082/1229 

Parental/Systemic, Reproductive and Offspring 

LOAEL=not determined

870.4100a

870.4200

Combined Chronic/ 

Carcinogenicity-rat

MRID 45109614 (2000) 

ppm=0, 100, 600, 6000, 20000

mg/kg/day (M/F)=0/0, 4.5/5.6, 

25/35, 246/339, 849/1135

NOAEL = 849/1135 mg/kg/day

LOAEL=not determined

no evidence of carcinogenicity

870.4100b

Chronic toxicity- dog

MRID 45109607 (1999)

mg/kg/day (M/F): 0, 5, 100, 1000

NOAEL = 1000 mg/kg/day, HDT

LOAEL=not determined

870.4300

Carcinogenicity-mouse

MRID 45109608 (1997)

ppm=0, 40, 800, 8000

mg/kg/day (M/F): 0/0, 5.4/6.5, 

108.9/ 133.7, 1115.1/1357.5 

NOAEL = 1115/1357 mg/kg/day (M/F)

mg/kg/day (M/F)= 0/0, 5.4/ 6.5, 108.9/133.7, 

1115.1/1357.5

LOAEL=not determined

no evidence of carcinogenicity

870.5100

Bacterial Reverse Mutation 

Test 

MRID 45109609

0.032,0.16,0.8,4,20 100, 500, 

2500, or 5000 /ug/plate 

(Salmonella strains) and 4, 20,

100, 500, 2500, or 5000 ug/p1ate 

(E. coli strain)

Negative

870.5300

Mammalian Cell Forward 

Gene Mutation

MRID 45109611

ug/ml= 250, 500, 1000, 2000

Negative

870.5375

In Vitro Mammalian Cell 

chromosome Aberration 

Assay

MRID 45109610

ug/ml=18.8-2400

Negative

870.5395

Bone Marrow Micronucleus

MRID 45109612

mg/kg/day= 200, 1000, 2000

Negative

870.5550

Unscheduled DNA synthesis

MRID 45109613

mg/kg/day=600 or 2000

Negative
Foramsulfuron Registration Review Scoping Document

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Guideline No./ Study Type MRID No. (year)/

Classification/Doses

Results

870.6100

Acute Neurotoxicity

Waived by HASPOC

870.6200

Subchronic Neurotoxicity

Waived by HASPOC

870.7485

Metabolism and 

pharmacokinetics

MRID 45109427-31

Single oral dose at 10 or 1000 

mg/kg, or as a repeated oral dose 

at 10 mg/kg/day for 1, 9, 14 days. 

Four male, bile duct-cannulated, 

rats also received a single oral 

dose of [14C-phenyl] 

foramsulfuron at 10 mg/kg, and 

another group of rats (2/sex) 

received a single oral dose of [14Cpyrimidyl] foramsulfuron at 10 

mg/kg.

Overall metabolism was similar between the sexes 

and the various dose groups. For the single lowand high-dose groups, the majority of the 14C-dose 

was excreted as parent (74.4-80.8% dose), most of 

which was recovered in the feces (72.3-80.4% 

dose). Parent compound was also the only 14Cresidue found in the feces of repeated dose males 

(64.3%) and females (98.1%). Other minor 

metabolites identified in feces and urine included 

the cleavage product AE F 153745 (1.6-11.0% 

dose) and the free amine metabolite AE F130619 

(0.8-3.5% dose). Minor amounts of unknown(s) 

were also detected in the feces (≤5.9% dose) and 

urine (≤3.9%).

870.7800

Immunotoxicity

Required: Data Gap
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Attachment 3. Registered Foramsulfuron Products and Use Patterns

Use Patterns of End-use Product Formulations of Foramsulfuron.

EPA Reg. No. & 

(Formulation types) % AI Use sites Application method/Comments

264-685 (WDG) 35.0 Field, sweet and pop corn 

Air and ground broadcast spray, 2 applns. 

per year. A RTI was not specified. 

Maximum application rate is 0.038 lbs ai/A. 

264-686 (WDG) 30.0 Field corn Ground broadcast spray, one appln./season. 

Maximum application rate is 0.028 lbs ai/A.

264-688 99.1

Field, sweet and pop corn, 

golf course turf, sports fields, 

commercial lawns, cemeteries, 

parks, campsites, recreation 

areas, home lawns, roadsides, 

school grounds, and sod farms.

NA [Technical Active Ingredient]

432-1266 (SC) 2.34

(0.19 lbs 

ai/gal)

Commercial and residential turf 

Ground broadcast and spot treatments; 2 

applns. @14-21 day interval. Maximum 

single application rate is 0.052 lbs ai/A.

432-1519 (WDG) 19.8 Commercial and residential turf

Ground broadcast and spot treatments; 2 

applns. per year @ 14-21 day interval. No 

interval specified for the spot treatment use.

Abbreviations used: AI = active ingredient, NA = not applicable, RTI = re-treatment interval: SC=soluble 

concentrate, WDG = water dispersible granule or dry flowable (DF).
Foramsulfuron Registration Review Scoping Document

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Attachment 4. International Residue Limit Status

Foramsulfuron (122020; 07/03/12)

Summary of US and International Tolerances and Maximum Residue Limits 

Residue Definition: Tolerance exemption

US Canada Mexico1 Codex

40 CFR 180.1219

Foramsulfuron; exemption from 

the requirement of a tolerance. 

2-[[[[(4,6-dimethoxy-2-

pyrimidinyl)amino]carbonyl]

amino]sulfonyl]-4-(formylamino)-

N,N-dimethylbenzamide

None

Commodity Tolerance (ppm) /Maximum Residue Limit (mg/kg)

US Canada Mexico1 Codex2

The pesticide foramsulfuron is exempted from 

the requirement of a tolerance in corn, field, 

grain/corn, field, forage/ corn, field, 

stover/corn, pop, grain/corn, pop, forage/corn, 

pop, stover; corn, sweet, forage; corn, sweet, 

kernel plus cob with husks removed; corn, 

sweet, stover when applied as a herbicide in 

accordance with good agricultural practices.

MRLs with No US Equivalent

Field Corn 0.01

Completed: M. Negussie; 07/05/2012

1 Mexico adopts US tolerances and/or Codex MRLs for its export purposes.