2 of 30 

IPBC was first registered in the United States in 1975 for use as a disinfectant, 

fungicide, and algaecide. Currently, there are 106 registered products for formulating and 

end uses. See Appendix C. A Reregistration Eligibility Decision (RED) was issued by 

EPA in March 19971

. 

The chemical name (IUPAC) for this active ingredient in this registration review 

case is 3-iodoprop-2-ynyl-N-butylcarbamate (IPBC). Troysan KK-108A is a trade name 

that refers to a specific product, which is no longer registered, but contained IPBC as an 

active ingredient. Although the previous name for this registration review case is Troysan 

KK-108A, hence forward this case will be referred to by its chemical name, 

iodopropynylbutylcarbamate (IPBC). 

Use Patterns 

Materials Preservatives

Adhesives, Industrial (Nonfood Contact) 

Hides / Leather / Leather Products (Surfaces) 

Paper (Stored) 

Textiles / Cordage Products 

Metalworking Cutting Fluids 

Coatings, Industrial 

Specialty Products (Food and Nonfood Contact) 

Wood Preservatives

 Pressure and Non-pressure treatment 

 Sapstain 

Science Findings 

The Agency has conducted a review of the available product chemistry, 

environmental fate, and ecotoxicity data for iodopropynylbutylcarbamate (IPBC). The 

primary source of information for this assessment was the 1997 IPBC RED. The findings 

are summarized below. 

Product Chemistry Summary (TGAI 99.7%) 

Common Name: 3-Iodo-2-propynyl-N-butylcarbamate (IPBC);

3-Iodopropynylbutylcarbamate

Chemical Name: Carbamic acid, butyl-, 3-iodo-2 propynyl ester 

CAS Registry Number: 55406-53-6 

OPP Chemical Code: 107801 

Case: 2725 

Molecular Formula: CH3-(CH2)3-NH-COO-CH2C≡C-I 

C8H12INO2

Trade and Other Names: Troysan Polyphase Anti-Mildew 

 

1

 (http:/www.epa.gov/pesticides/reregistration/ipbc) 
3 of 30 

Troysan Polyphase KK-108A 

Troysan KK-108A 

Permatox IBP 

ASC 67000 

Woodlife 

Molecular weight: 281.1g/mol

Molecular Structure: 

Figure 1. Structure of IPBC 

Color: Off-white, dull color powder 

Physical State: Crystalline Powder 

Odor: Sharp pungent odor. Faint odor of iodine; Faint sweet odor 

Stability: The substance is: 

stable at room temperature and at 55°C for 14 days, 

stable on contact with aluminum, aluminum acetate, iron, 

iron acetate and zinc at 54 °C for 14 days, but 

unstable on contact with copper, copper acetate and zinc 

acetate at 54°C for 14 days. 

Oxidation/Reduction: N/A. Does not contain an oxidizing or reducing agent or 

functional group of significant activity.

Flammability-Flash Point: IPBC is not highly flammable. It has no pyrophoric 

property and it does not undergo spontaneous combustion.

Explodability: Not explosive.

Storage Stability: Stable for 12 months at 20-30 °C; chemically and 

physically stable for a period of 1 year in its commercial 

container when kept at 25°C and 50% relative humidity.

Miscibility: Miscible with water

Corrosion Characteristics: Corrosive to mild steel. Store in Poly containers.

Dielectric breakdown voltage: N/A
4 of 30 

pH: 7.01 

6.1 (1% w/v suspension) 

UV/Visible absorption: Maxima at 191 nm and 227 nm

Viscosity: N/A

Melting point: 65 - 66° C. 

Boiling Point: N/A 

Density: 1.77 gm/cc at 20°C. 

1.575 g/mL 

Specific Gravity: 1.51 -1.57 at 25°C 

Dissociation Constant: Not applicable, non-ionic material. 

log P (octanol-water): log Kow = 2.4/Estimated (EPI Suite) 

2.81 at 25°C

Log10Pow = 2.3, Pow=204

Solubilities: In water, 156 mg/L at 20°C (Toxnet); 

150 mg/l; 0.168 g/l (pH 7) at 20°C. 

IPBC is not very water soluble, but is very soluble in 

methanol (>1000 g/l) and other organic solvents. 

Vapor Pressures: <1.8 x 10-6& 5 x 10-6mm Hg at 20°C & 30°C, respectively. 

5.25 x 10-5 mm Hg at 30° C (Toxnet) 

Henry's Law Constants: 8.93 x 10-9 atm-m3/mole at 25°C/Estimated (EPI Suite)

1.2x10-7 atm-cu m/mol at 30°C/Estimated (Toxnet)

Enforcement Analytical 

Method: HPLC-UV and GC-FID. Methods of analysis for residues 

are HPLC-MS/MS. 
5 of 30 

All product chemistry data requirements have been satisfied for the active 

ingredient IPBC. (Source: MRIDs 41722901, 41802501, 42389802, 41802601, 

42257901, 43709901, 44721802, 47203402, 47421802, & 44871101) 

Environmental Fate Summary 

The Agency has reviewed five environmental fate studies for IPBC; the 

environmental fate guideline study results are summarized in Table 1 and the degradates 

are listed in Table 2. The Agency's conclusions for the degradation, metabolism, and 

mobility studies are as follows. 

(1) Degradation Studies (Abiotic) 

Hydrolysis 

The hydrolysis (guideline 161-1) study provides marginally acceptable data 

because the study was conducted in non-sterile buffer solutions. The interpretation of the 

hydrolysis data is not affected by non-sterile conditions because minimal microbial 

contamination was observed in the buffer solutions. 

Radiolabeled IPBC was stable with a half-life of >30 days (k=0.0064 day-1) in pH 

5 buffer solution, had a half-life of 139 days (k= - 0.0049 day -1) in pH 7 buffer solution, 

and 0.947 days (k= - 0.732 day 1) in pH 9 buffer solution. Propargyl butyl carbamate 

(PBC) was identified as the only hydrolysis degradate. The guideline requirement is 

fulfilled (MRIDs 40947405 & 42329301). 

(2) Metabolism Studies 

In an Aerobic Soil Metabolism (Guideline 162-1) study, radiolabeled IPBC, at 1 

μg/g, had a half-life of 2.13 hours (k=0.326 hours -1) in a non-sterile, Blackoar loam soil 

at 22°C. The half-life of IPBC was 8.60 days (k=0.081 hours-1) in a nonsterile, Blackoar 

loam soil at 5°C. The primary degradate of IPBC at both temperatures was identified as 

PBC (parent compound minus the iodine group) and the half-life of PBC was 4.31 days 

(k=0.161 days-1) at 22°C. The degradate PBC further degrades to form CO2, bound soil 

residues, and an unidentified metabolite. The guideline requirement is fulfilled (MRID 

42329302). 

Degradation Pathway of IPBC in Aerobic Soil 
6 of 30 

Marginally acceptable data for Anaerobic Soil Metabolism (guideline 162-2) 

and Anaerobic Aquatic Metabolism (Guideline 162-3) were provided. The data are 

deemed marginally acceptable because low material balances were detected at later 

sampling intervals. The interpretation of anaerobic aquatic data is not affected by low 

material balance because supplemental information was provided to quantify and identify 

non-trappable volatile degradates. 

Radiolabeled IPBC, at 6 μg/g, had a half-life of 1.5 hours (k=0.464 hours-1) in a 

nonsterile, static, anaerobic (pe + pH <7) sediment-water test system at 22 °C. The 

anaerobic aquatic metabolism half-life of IPBC was 13.3 hours (k=0.052 hours-1) in a 

sterile, static, sediment-water test system. Radiolabeled residues were predominantly 

detected (80% of applied IPBC) in the water phase of sediment-water systems, and the 

primary degradate of IPBC was PBC. The half-life of PBC was 11.5 days (k=0.060 days1

) along with the secondary degradates of IPBC including 2-propenyl-butylcarbamate (2-

PBC) and two unidentified compounds. Volatile degradates were identified as PBC, 2-

PBC, CO2 and possibly CH4. The guideline requirement is fulfilled (MRID 42481601). 

Degradation Pathway of IPBC in Anaerobic Aquatic Systems 

(3) Mobility Studies 

Marginally acceptable data for the unaged portion of the Adsorption/Desorption 

(Guideline 163-1) data requirement were provided. The data are deemed marginally 

acceptable because IPBC degradation was observed during equilibration, however, the 

interpretation of mobility is not affected by IPBC degradation because the Freundlich 

adsorption coefficients (Kads) for IPBC are low. Low Freundlich coefficients indicate that 

any residues of IPBC in the environment have the potential to reach either ground-or 

surface-water and be associated with water in the presence of soil and sediment. The 

mobility of IPBC degradates cannot be determined at this time because no aged soil 

column leaching data or batch equilibrium data for individual degradates were provided. 

Radiolabeled IPBC had Kads values of 0.67 to 2.46 ml/g in a Hanford sandy loam, 

Centhan sand, Blackoar loam, Mexico silty clay, and an Evesboro sand. Freundlich 

desorption coefficients (Kads) ranged from 3.4 to 31 ml/g. Degradation of IPBC was 

observed in the equilibration solutions. The major degradate of IPBC was PCB. IPBC 

adsorption was not correlated to organic matter content, clay content, and cation 
7 of 30 

exchange capacity of soil. The guideline requirement is partially fulfilled (MRID 

41975207). 

In Summary: IPBC is moderately soluble in water at 127 mg/l (ppm), semivolatile (VP = 4.6 X 10-4 mm Hg), but is unlikely to volatilize from water based on the 

Henry's Law Coefficient of 8 .9 x 10-9 atm m3 mole. It has some potential to 

bioconcentrate in fish based on the Log Kow of 2.45, but is not expected to be significant 

because the Log Kow (Log P) is <3. 

IPBC is stable to hydrolysis at pH 5 (with a half-life of >30 days) and pH 7 with a 

calculated half-life of 139 days, but is susceptible at pH 9 with a half-life of <1 day. The 

primary degradate was PBC (MRID 42329301). In aerobic soil, the half-lives were 2.1 

hours and 8.6 hours at 22 and 5 °C, respectively. The degradate PBC was formed and 

degraded to CO2, bound residues, and an unidentified degradate (MRID 42329302). In 

anaerobic aquatic environments (representing sediment), the half-lives were 1.5 and 13.3 

hours under non-sterile and sterile conditions at 22 °C, respectively. As expected parent 

compound residues were primarily detected in the water phase. PBC degraded with a 

half-life of 11.5 days under non-sterile conditions to form 2-PBC and two unidentified 

compounds (MRID 42481601). IPBC is mobile to moderately mobile in soil:water 

systems with Kads values of 0.67 to 2.46 ml/g. Sorption to soil was not affected by 

organic matter and clay contents of soil (MRID 41975207). 

Table 1. Environmental Fate Data Summary for Iodopropynylbutylcarbamate (IPBC)

OPP 

Guideline Fate Studies Half-Life Degradates Study Status 

161-1 Hydrolysis 

pH 5 

pH 7 

pH 9 

>30 days (Stable) 

139 days (Stable) 

<1 day (0.947 d) 

None 

None. 

Major 

degradate: 

Parent IPBC 

with the loss of 

iodine atom 

(Propargyl 

butyl carbamate 

(PBC)) 

Supplemental 

MRID 40947405

MRID 42329301 

162-1 Aerobic Soil Metabolism 

IPBC: 

Non-Sterile Conditions: 

Blackoar Loam Soil at 22oC 2.13 hours 

Major 

degradates: 

PBC 

Acceptable 

MRID 42329302
8 of 30 

OPP 

Guideline Fate Studies Half-Life Degradates Study Status 

Blackoar Loam Soil at 5oC 

SterileConditions: 

Blackoar Loam Soil at 22oC 

PBC: 

Non-Sterile Conditions: 

Blackoar Loam Soil at 22oC 

Blackoar Loam Soil at 5oC: 

8.6 hours 

Slow degradation of IPBC 

was also observed in 

sterile soil. 

4.30 days 

PBC was more resistant to 

degradation at 5°C. 

Mineralization rates were 

significantly lower at 5°C. 

PBC 

Mineralized to 

Carbon dioxide 

(CO2) 

162-2 Anaerobic Soil Metabolism 

IPBC: 

Non-Sterile Conditions: 

Static Sediment water at 22°C 

Sterile Conditions: 

Static Sediment water at 22°C 

PBC: 

Non-Sterile Conditions: 

Static Sediment water at 22°C 

1.5 hours 

13.3 hours 

11.5 days 

Major 

degradates: 

PBC 

PBC 

2-propenylbutylcarbamate 

(2-PBC) 

Mineralized to 

CO2 & Me 

IPBC and its 

major degradate 

PBC 

should not 

persist in 

anaerobic aquatic 

or anaerobic 

soils. 

Acceptable 

MRID 42481601 

162-3 Anaerobic Aquatic 

Metabolism DT50

Major 

degradates: 

Acceptable 

MRID 42481601 
9 of 30 

OPP 

Guideline Fate Studies Half-Life Degradates Study Status 

IPBC: 

Non-Sterile Conditions: 

Static Sediment water at 22°C 

SterileConditions: 

Static Sediment water at 22°C 

PBC: 

Non-Sterile Conditions: 

Static Sediment water at 22°C 

1.5 hours 

13.3 hours 

11.5 days 

 PBC 

PBC 

 2-PBC 

2-PBC 

mineralized to 

CO2 & Me. 

IPBC and its 

major degradate 

PBC 

should not 

persist in 

anaerobic aquatic 

or anaerobic 

soils. 

2 unidentified 

compounds. 

163-1 Leach/Adsorption/Desorption 

Studies-Batch Equilibrium 

Unaged 

Radiolabeled P-100 had 

Freundlich adsorption coefficient 

(Kads) of 0..67 to 2.46 ml/g in a 

Hanford sandy loam, Centhan 

sand, Blackoar loam, Mexico, 

silty clay, and a Evesboro sand. 

Freundlich desorption 

(Kdes)coefficients ranged from 

3.4 to 31 ml/g. 

Koc ranged from 61 – 309. 

IPBC is mobile in soil and 

aquatic environments 

Soil 

Type 

Kads Kdes Koc

Sandy 

Loam 

0.676 3.43 90.1 

Sand 1.42 18.7 309 

Loam 0.976 10.0 61 

Silty 

clay 

1.16 31.3 89.2 

Sand 2.46 15.6 123 

Propargyl butyl 

carbamate (PBC) 

High to moderate 

mobility based 

upon Koc values 

ranging from 62-

310. 

Acceptable 

MRID 41975207 
10 of 30 

Table 2. Degradates of Iodopropynylbutylcarbamate (IPBC) 

IPBC (Parent): 

Iodopropynyl butylcarbamate (IPBC) C8H12INO2 

CAS: 55406-53-6 

Molecular Weight: 281.09

PBC: 

Propargyl butylcarbamate C8H13NO2

CAS:76114-73-3 

 Molecular Weight: 155.19 

2-PBC: 

2-propynyl-butylcarbamate (2-PBC) 

CAS:76114-73-3 C8H13NO2

 Molecular Weight: 155.19 

CO2 & CH4: 

O=C=O & 

Carbon dioxide & Methane, respectively 

The Agency did not conduct an environmental fate assessment for IPBC because 

of lack of data. However, the Agency needs to conduct an environmental fate assessment 

for material preservatives (including IPBC) that may potentially pass through waste water 

treatment plants (WWTPs) and may be discharged into terrestrial and aquatic 

environments. The Agency also anticipates conducting an environmental fate assessment 

for IPBC used in wood preservatives. For these assessments the Agency anticipates 

needing those data outlined on page 15 of this document. 

Water Quality 

IPBC is not identified as a cause of impairment for any water bodies listed as 

impaired under section 303(d) of the Clean Water Act, based on information provided at 

the Agency’s National Pesticides Cause of Impairment of Waters website (searched April 

7, 2011)2

. In addition, no Total Maximum Daily Loads (TMDL) have been developed 

for IPBC, based on information provided at the Agency’s National Pesticide TMDL web 

site (searched April 7, 2011)3

. More information on impaired water bodies and TMDLs 

can be found at http://www.epa.gov/owow/tmdl/. The Agency invites submission of 

water quality data for this pesticide. To the extent possible, data should conform to the 

quality standards in Appendix A of the OPP Standard Operating Procedure: Inclusion of 

Impaired Water Body and Other Water Quality Data in OPP’s Registration Review Risk 

Assessment and Management Process (see: 

http://www.epa.gov/oppfead1/cb/ppdc/2006/november06/session1-sop.pdf ), in order to 

ensure they can be used quantitatively or qualitatively in pesticide risk assessments. 

 

2

 . http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_group_id=885 3

http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_group_id=885&p_p

ollutant_group_name=PESTICIDES
11 of 30 

Ecological Effects Summary 

The Agency has reviewed nineteen ecotoxicology studies and three mammalian 

toxicity studies for IPBC. The eighteen studies submitted on the 97.2 to 98.7% active 

ingredient were all found to be acceptable for use in a hazard assessment. Ecotoxicity 

guideline studies and the results are summarized in Table 3. The Agency's conclusions 

for the avian, mammalian, aquatic effects and plant studies are as follows. 

Toxicity to Birds 

Available data indicate that IPBC is slightly toxic to birds on an acute oral basis 

and practically nontoxic to birds on a sub-acute dietary basis. 

Toxicity to Mammals 

The Acute Oral LD50 in female rats was 1.1 g/kg with a Toxicity Category of III 

and indicates slight toxicity. 

IPBC did not affect fertility and does not possess significant potential with respect 

to toxicity to reproduction. 

Toxicity to Aquatic Animals 

On an acute basis, IPBC is highly to very highly toxic to freshwater fish; highly 

toxic to freshwater invertebrates; highly toxic to estuarine/marine fish and highly to very 

highly toxic to estuarine/marine invertebrates. 

Toxicity to Plants 

Algal toxicity data indicate that IPBC is detrimental at less than 1.0 ppm to green 

alga and marine diatom. Therefore, additional Tier II (dose response) studies listed on 

page 15 of this document are required. 

Table 3. Ecotoxicity Data Summary for IPBC

MRID COMMON 

NAME 

TAXONOMIC 

NAME 

GUIDELINE 

TEST

TYPE

% 

AI 

STUDY

TIME

DOSE

TYPE

TOXI

CITY

TOX 

LEVEL NOEL Study 

 Status 

TOX 

CATEGORY

Avian Acute Oral Toxicity

42430901 

42623605 

Bobwhite 

quail 

Colinus 

virginianus 

850.2100

(71-1) 

O 98.2 14 D LD50 749 mgk <292 Acceptable Slightly toxic

43491806 Bobwhite 

quail 

Colinus 

virginianus 

850.2100

(71-10) 

O 97.5 21 D LD50 970 mgk 292 Acceptable Slightly toxic

Avian Subacute Dietary Toxicity

42430902 Bobwhite 

quail 

Colinus 

virginianus 

850.2200

(71-2a) 

D 98.2 8 D LC50 >3881 ppm 736 Acceptable Practically 

nontoxic 

42430903 Mallard 

duck 

Anas 

platyrhynchos

850.2200

(71-2b) 

D 98.2 8 D LC50 >5620 ppm 562 Supplemental Practically 

nontoxic 

42623604 Mallard 

duck 

Anas 

platyrhynchos 

850.2200

(71-2b) 

D 98.2 8 D LC50 >5000 ppm 562 Acceptable Practically 

nontoxic 

43491807 Bobwhite 

quail 

Colinus 

virginianus 

850.2200

(71-2a) 

D 97.5 8 D LC50 >5620 ppm 5620 Acceptable Practically 

nontoxic 

43491808 Mallard 

duck 

Anas 

platyrhynchos 

850.2200

(71-2b) 

D 97.5 8 D LC50 >5620 ppm 5620 Acceptable Practically 

nontoxic 
12 of 30 

MRID COMMON 

NAME 

TAXONOMIC 

NAME 

GUIDELINE 

TEST

TYPE

% 

AI 

STUDY

TIME

DOSE

TYPE

TOXI

CITY

TOX 

LEVEL NOEL Study 

 Status 

TOX 

CATEGORY

Freshwater Fish Acute Toxicity

41627107 Rainbow 

trout 

Oncorhynchus

mykiss 

850.1075

(72-1) 

F 97.7 96 hr LC50 67 ppb 16 Acceptable Very highly 

toxic 

43530209 Rainbow 

trout 

Oncorhynchus 

mykiss 

850.1075

(72-1) 

F 97.5 96 hr LC50 72 ppb <22 Supplemental Very highly 

toxic 

41627106 Bluegill 

sunfish 

Lepomis 

macrochirus 

850.1075

(72-1) 

F 97.7 96 hr LC50 226 ppb 140 Acceptable Highly toxic 

43530208 Fathead 

minnow 

Pimephales 

promelas 

850.1075

(72-1) 

F 97.5 96 hr LC50 200 ppb 96 Supplemental Highly toxic 

Freshwater Fish Early Life-Stage (Chronic)Toxicity

42389801 Fathead 

minnow 

Pimephales 

promelas 

850.1400

(72-4a) 

F 97.25 35 D LOEC

Growth

17.28

17.28

ppb 8.97 Supplemental 

MATC: 

>8.97 and 

<17.28 ug 

a.i./l 

Geometric 

Mean 

MATC = 

12.5 ug a.i./l 

Chronic toxic 

effects 

Freshwater Invertebrate Acute Toxicity

41627108 Water 

 flea 

Daphnia 

magna 

850.1010

(72-2) 

S 98.7 48 hr EC50 956 ppb 312 Supplemental Highly toxic 

43530210 Water 

 flea 

Daphnia 

magna 

850.1010

(72-2) 

F 97.5 48 hr EC50 160 ppb 76 Acceptable Highly toxic 

Daphnid Chronic Toxicity 

41975205 

42634302 

Water 

 flea 

Daphnia 

magna 

850.1300

(72-4) 

F 97 21D EC50

LOEC

126 

99.3

ppb 50 Supplemental 

MATC: >50 

and <99.3 

ug /l 

Geometric 

Mean 

MATC = 

70.4 ug /l

Chronic toxic 

effects 

Estuarine/Marine Fish Acute Toxicity

42168203 Sheepshead

minnow Cyprinodon 

variegatus 

850.1075

(72-3) 

F 97.2 96 hr LC50 418 ppb 140 Acceptable Highly toxic 

Estuarine/Marine Oyster Acute Toxicity (Shell-Deposition) - Invertebrates

42168202 Eastern 

oyster 

Mollusca 

Crassostrea 

virginica 

850.1025

(72-3b) 

F 97.2 96 hr EC50 23.4 ppb <5.3 Acceptable Very highly 

toxic 

Estuarine/Marine Mysid Acute Toxicity - Invertebrates

42168204 Mysid 

Crustacea 

Americamysis

bahia 

850.1035

(72-3) 

F 97.2 96 hr LC50 89.8 ppb 19 Acceptable Very highly 

toxic 

Algal Toxicity (Aquatic (Algal) Plant Growth Tier II)

43530211 Green 

algae 

Selenastrum 

capricornutum

850.5400

(123-2) 

S 97.5 5 D EC50 100 ppb <89 Acceptable Detrimental 

effects 

Mammalian Acute Oral Toxicity

00148277 Rat 81-1 99 LD50

LD50

1.1 (F)

1.5 

(M&F)

g/kgbw 

Acceptable Slightly toxic 

(III) 
13 of 30 

MRID COMMON 

NAME 

TAXONOMIC 

NAME 

GUIDELINE 

TEST

TYPE

% 

AI 

STUDY

TIME

DOSE

TYPE

TOXI

CITY

TOX 

LEVEL NOEL Study 

 Status 

TOX 

CATEGORY

Mammalian Subchronic Oral Toxicity

40947401 SpragueDawley 

Rats 

82-1 99 13 wks LEL 50 mg/kgbw/ day20 Supplemental Increased liver 

to body weight 

ratio at 125 

mg/kg/day 

45812301 Rats 870.3100

(82-1) 

98 90 days LOAEL 35 mg/kgbw/day20 Acceptable decreased body 

weight in 

males, and 

salivation and 

breathing 

sounds in 

females 

Two-Generation Reproductive Toxicity in Rats

40990402 SpragueDawley 

Rats 

83-4 97 Parental 

toxicity

LEL

>37.5 mg/kg

-bw/ 

day 

15 for 

parental 

toxicity 

NOAEL 

37.5 

for 

reprodu

ctive 

toxicity

NOAEL 

Acceptable No adverse 

effects on 

reproductive 

indices or mating 

Performance. 

Reduced body 

weight and food 

consumption. 

Decreased mean 

live birth index.

44478801 Crl:CD 

(SD)BR 

VAF Rats 

870.3800

(83-4) 

>97 LOAEL

for 

systemic

/reproduc

tive

toxicity 

30 mg/kg

-bw/ 

day 

10

for 

systemic

/reprodu

ctive

toxicity

Acceptable Salivation, 

paddling with 

both forepaws, 

and hunched 

posture; 

thickened 

stomach lining; 

increased ovary 

weight; 

reduced food 

consumption; 

reduced pup 

survival; and 

retardation of 

pup growth. 

Oral Developmental Toxicity

40990401 SpragueDawley 

Rats

83-3 98 LEL 

Maternal

Toxicity 

DevelopMental 

Toxicity

125 

125 

mg/kgbw/day

50 

50 

Acceptable 

Reduced 

body weight 

gain 

Incompletely 

ossified 

frontal skull 

bones and 

pelvic girdles

42481604 New 

Zealand 

white 

rabbits 

83-3 LEL 

Maternal

Toxicity 

DevelopMental 

Toxicity

50 

50 

mg/kgbw/day

20 

50 

Acceptable 

Increased 

mortality, 

clinical signs, 

and 

decreased 

body weight 

gain 
14 of 30 

MRID COMMON 

NAME 

TAXONOMIC 

NAME 

GUIDELINE 

TEST

TYPE

% 

AI 

STUDY

TIME

DOSE

TYPE

TOXI

CITY

TOX 

LEVEL NOEL Study 

 Status 

TOX 

CATEGORY

In-vitro Bacterial Mutagenicity Testing (Ames Test)

41975206 Salmonella Salmonella 

typhimurium 

strains 

TA1535, 

TA1537, 

TA1538, 

TA98 and 

TA100, with 

and without 

metabolic 

activation.

870.5140

84-2(a) 

97 Acceptable Nonmutagenic in 

all five 

strains with 

and without 

metabolic 

activation at 

all 

concentration

s tested (1-

1000 

μg/plate). 

Test Type—O: oral; D: dietary; S: static; F: flow-through 

Tox Level—mgk: milligrams per kilogram-body weight; ppm: parts per million (equivalent to milligrams per kilogram-diet (mg/kgdiet) for dietary exposure and milligrams per liter (mg/L) for aquatic exposures); ppb: parts per billion (equivalent to micrograms per 

liter (μg/L) for aquatic exposure) 

Categories of acute toxicity for aquatic organisms (U.S. EPA, 2004) based on EC50/LC50(mg/L): < 0. 1 very highly toxic; 0.1-1 

highly toxic; >1-10 moderately toxic; >10-100 slightly toxic; >100 practically nontoxic. Toxicity categories for terrestrial plants have 

not been defined. 

Categories of acute toxicity to terrestrial animals, avian and mammalian (U.S. EPA, 2004). LC50 (ppm): < 50 very highly toxic; 50 

- 500 highly toxic; 501 – 1000 moderately toxic; 1001-5000 slightly toxic; >5000 practically non-toxic. LD50 (mg/kg bw): < 10 very 

highly toxic; 10 - 50 highly toxic; 51 - 500 moderately toxic; 501-2000 slightly toxic; >2000 practically non-toxic.

Ecotoxicity data are adequate to provide the Agency with sufficient information to 

determine appropriate label precautions. 

Adverse Ecological Incidents 

There are no reported incidents in the Agency’s Ecological Incident Information 

System (EIIS) regarding IPBC. The absence of documented incidents does not necessarily 

mean that such incidents did not occur. 

Ecological Effects Risk Assessment 

An ecological risk assessment was not conducted on the IPBC’s use patterns 

described in this document. IPBC uses that have potential for environmental exposure are 

material preservatives discharges. The Agency anticipates the need to conduct environmental 

fate and ecological risk assessments for material preservatives that potentially pass through 

waste water treatment plants (WWTPs) and may be discharged into terrestrial and aquatic 

environments. The Agency also anticipates the need to conduct an ecological risk assessment 

for the IPBC used in outdoor wood preservatives. For this ecological risk assessment, 

including an endangered species assessment for all uses, the Agency anticipates needing the 

ecotoxicity data outlined on page 15 of this document. 

The Agency has not conducted a risk assessment for IPBC that supports a complete 

endangered species effects determination. The ecological risk assessment planned during 

registration review will allow the Agency to determine whether IPBC’s use has “no effect or 

“may affect” federally listed threatened or endangered species (listed species) or their 

designed critical habitats. When an assessment concludes that a pesticide’s use “may affect” 

a listed species or its designated critical habitat, the Agency will consult with the U.S. Fish 

and Wildlife Service and/or National Marine Fisheries Services (the Services), as 

appropriate.
15 of 30 

Environmental Fate and Ecotoxicity Data Gaps and Anticipated Work 

Environmental fate and ecological risk assessments have not been conducted for 

IPBC. The Agency needs to conduct environmental fate and ecological risk assessments 

for material preservatives that potentially pass through waste water treatment plants 

(WWTPs) and may be discharged into terrestrial and aquatic environments. The Agency 

also needs to conduct an ecological risk assessment for IPBC used in outdoor wood 

preservatives. Therefore, the Agency anticipates needing the proposed environmental fate 

and ecotoxicity data for all registered uses of IPBC. The following environmental fate 

and ecotoxicity data are needed to conduct an environmental fate and ecological risk 

assessments: 

• The Agency anticipates needing the following data in order to conduct a 

complete environmental fate assessment for material preservative uses: 

o (GLN 850.6800) Modified activated sludge respiration inhibition 

• The Agency anticipates needing the following ecological effects and 

environmental fate data in order to conduct a complete ecological risk 

assessment, including an endangered species assessment for antisapstain and 

outdoor wood preservative uses of IPBC: 

Anticipated Ecological Effects Data Needs: 

o (GLN 850.1350) Mysid Chronic Toxicity Test; 

o (GLN 850.1400) Fish early-life stage toxicity test 

o (GLN 850.3020) Honeybee Acute Contact Toxicity; 

o (GLN 850.3030) Honey Bee Toxicity of Residues on Foliage; 

o (GLN 850.4400) Aquatic Plant Toxicity Test Using Lemna gibba, Tier II; 

and 

o (GLN 850.5400) Algal Toxicity Test, Tier II - dose response studies on 

Anabaena flos- aquae (blue-green cyanobacteria), Navicula pelliculosa 

(freshwater diatom), and Skeletonema costatum (marine diatom). 

 Anticipated Environmental Fate Data Needs: 

o (GLN 835.2240) Photodegradation in water; 

o (GLN None) (Special study) Leachability of wood preservatives in water 

contact (AWPA E11-97); and 

o (GLN None) (Special study) leachability of IPBC from shingles. 
16 of 30 

Appendix A. Environmental Fate Guideline Study Justifications

Guideline Number: 850.6800; OECD 209

Study Title: Modified Activated Sludge, Respiration Inhibition Test for Sparingly Soluble 

Chemicals; Activated Sludge Respiration Inhibition Test

Rationale for Requiring the Data

An activated sludge, respiration inhibition test (ASRI) is needed to identify whether this pesticide could 

harm activated sludge microorganisms found in biological wastewater treatment systems. The Agency 

will use these data to determine the potential impact of this chemical on waste water treatment plants 

(WWTPs) as a result of respiration inhibition of activated sludge microorganisms. This test is also 

necessary to enable EPA to establish correct concentrations for use in the biodegradability test, if that 

test is determined to be adequate for assessing biodegradation potential. Furthermore, the results of the 

Activated Sludge Respiration Inhibition Test (ASRI) determine which biodegradation test is required. If 

the ASRI test EC50 is less than or equal to 20 mg/L, then either the Biodegradation in Activated Sludge 

Study or the Porous Pot Test is required. If the ASRI test EC50 is greater than 20 mg/L, then the applicant 

must choose either: (i) Ready Biodegradability or (ii) Biodegradation in Activated Sludge or the Porous Pot 

Test. If the antimicrobial passes the ready biodegradability study, then no further testing is required. If, 

however, the antimicrobial fails the ready biodegradability study, then the Biodegradation in Activated 

Sludge or the Porous Pot study is required. 

Practical Utility of the Data

1. How will the data be used?

The data will be used to assess potential adverse effects to activated sludge microorganisms. In addition, 

the data will be used to determine whether or not label restrictions are needed. The study will identify the 

inhibitory effect of this chemical on the treatment plant’s microorganisms’ respiration at different 

concentrations of the test substance and will identify the EC50, the effective concentration of the test 

substance at which the respiration rate is 50% of that shown by the control under conditions in this 

guideline. The data will also determine suitable non-inhibitory concentrations to be used in 

biodegradability tests. 

2. How could the data impact the Agency’s future decision-making?

If the data indicate a high degree of activated sludge respiration inhibition, a more rigorous test for 

biodegradation in wastewater treatment will be required than the ready biodegradability test. Also, if a 

high degree of respiration inhibition is demonstrated and biodegradation and/or sorption is indicated to be 

negligible, the Agency may require label restrictions or mitigation measures to insure that activated sludge 

microorganisms will not be adversely impacted. 
17 of 30 

Guideline Number: 835.2240 

Study Title: Photodegradation in Water

Practical Utility of the Data 

1) What is the value of the study? 

Biocides introduced into aqueous systems in the environment can undergo photolytic 

transformation by sunlight. Results from the photolysis study will indicate the stability and 

persistence of IPBC and potential degradates in an aquatic environment when exposed to 

sunlight. The Agency will evaluate the potential risks of concern. 

2) How would the data be used? 

The data would establish the significance of chemical photolysis as a route for degradation and 

identify, if possible, the photolytic degradation products formed that may adversely affect nontarget organisms and may contaminate water and food source of aquatic organisms. The data 

would also help establish the photolytic half-life of IPBC and possibly degradates, and assist in 

developing a degradation pathway. 

3) How could the data affect the risk assessment? 

The results of photolysis data would indicate if IPBC is persistent or if it degrades into 

degradation products that may adversely affect nontarget organisms and may contaminate their 

food. The results of the photolysis data would expand the understanding of the results of the 

hydrolysis data since environmental aquatic conditions usually involve exposure to sunlight. 

4) What is triggering the need for this data? 

Aqueous photodegradation data is needed to conduct the fate assessment to support material 

preservative and wood preservative uses for IPBC. 
18 of 30 

Guideline Number: AWPA E11-06 

Study Title: Aquatic leaching study for wood preservatives (Special Study) 

Rationale for Requiring the Data 

The results from the wood preservative leaching study would allow measurement of the leaching rate of

IPBC from treated wood windows, doors, and engineered components used in construction application 

where decay resistance is necessary. The purpose is to provide information on relative permanency of wood 

preservatives. The method is designed for waterborne preservatives and may not be applicable to other 

types of preservatives. For outdoor wood preservative uses, IPBC can reach surface water through direct 

contact or discharge to WWTPs. IPBC can also reach surface water or groundwater through run-off or 

leaching processes. If IPBC is leached from wood rapidly, then it may contaminate surface and drinking 

waters and also have potential adverse effects to non-target organisms and the aquatic environment. The 

Agency will evaluate the potential risks of concern. 

The Agency used a screening level model to assess potential exposures from wood preservative uses. The 

model has inherent uncertainties and limitations which may result in inaccurate exposure estimations. 

Therefore, the wood leaching rate data are required to conduct an environmental risk assessment.

Practical Utility of the Data 

1. How will the data be used? 

EPA will use the data to conduct the ecological effects and environmental fate assessments to determine the 

leachability of wood preservatives expressed as a percentage of the original preservative retention and to 

determine whether the ion levels in the leachate would be of toxicological concern. The amount of 

preservative leached is expressed as the ratio of the preservative contained in the leachate to the total 

preservative present. 

2. How could the data impact the Agency’s future decision-making?

This data is necessary for the Agency to accurately estimate potential environmental exposures and risks 

without which the Agency would assume the highest available leaching, resulting in the highest levels of 

environmental exposure and risk. Thus, the lack of these data could result in use restrictions for IPBC 

which are unnecessarily severe. Determination of appropriate risk mitigation measures is dependent on the 

results of these data. 

If future endangered species risk assessments are performed without these data, the Agency would have to 

assume that IPBC “may affect” non-target organisms directly (and endangered species indirectly), and use 

of IPBC may need to be restricted in areas where endangered species could be exposed. 

By refining the assessment, the Agency would be able to determine whether the mitigation imposed as part 

of the registration review process was appropriate for IPBC. The data evaluation could result in either 

additional or reduced environmental risk mitigation measures.
19 of 30 

Guideline Number: Special Study 

Study Title: Leachability of IPBC from Roofing Shingles 

Rationale for Requiring the Data 

Studies are needed to conduct environmental fate and ecological effects assessments and to determine 

the leachability of IPBC expressed as a percentage of the original preservative retention; and to confirm 

that ion levels in the leachate would be of no toxicological concern. 

Practical Utility of the Data 

2. How will the data be used? 

EPA will use the data to determine the leachability of IPBC expressed as a percentage of the original 

preservative retention. The amount of preservative leached is expressed as the ratio of the preservative 

contained in the leachate to the total preservative present. Study provides data to assess the 

environmental leaching characteristic of shingles impregnated or coated with IPBC. 

2. How could the data impact the Agency’s future decision-making? 

If future endangered species risk assessments are performed without these data, the Agency would have 

to assume that IPBC “may affect” non-target organisms directly (and endangered species indirectly), 

and use of IPBC may need to be restricted in areas where endangered species could be exposed. The 

lack of these data will limit the flexibility the Agency and registrants have in coming into compliance 

with the Endangered Species Act and could result in use restrictions for IPBC which are unnecessarily 

severe. 

Also, extrapolating risk conclusions used in the environmental modeling may either underestimate or 

overestimate potential exposures and risks. Such leaching data would be useful in refining the 

preliminary risk assessment and determining whether the Agency’s assessment is an accurate 

estimation of potential exposures and risks. Risk mitigation measures may also be impacted by the 

results of these data. 

By refining the assessment, the Agency would be able to determine whether the mitigation imposed as 

part of the registration review process was appropriate for IPBC. The data evaluation could result in 

additional or reduced environmental risk mitigation measures. 
20 of 30 

Appendix B: Ecological Guideline Study Justifications 

Guideline Number: 850.1350 

Study Title: Mysid Chronic Toxicity Test

Practical Utility of the Data 

1) What is the value of the study? 

Invertebrates serve as food for fish, birds, crustaceans, and even whales. The protection of non-target 

invertebrates is essential to the food chain in any healthy ecosystem. The value in the Mysid 

(850.1350) chronic toxicity test is that it provides information on the effects of pesticides on mortality, 

growth, and reproduction over a longer term (28 days for Mysids) compared to acute studies. Data are 

obtained from the first generation (G1) and the second generation (G2), thus allowing examination of 

the complete invertebrate life cycle for toxicity. 

2) How would the data be used? 

Data would be used to calculate LC50’s for mortality, EC50’s for growth, a NOAEC, and a MATC 

(maximum acceptable toxicant concentration). The data would allow the Agency to determine chronic 

effects, including effects on reproductive success and growth, to marine invertebrates from water 

column exposure to IPBC. 

3) How could the data affect the risk assessment? 

Because acute toxicity data alone are not a reliable indicator of chronic toxicity, chronic toxicity data 

are also required. The Agency cannot make the assumption that a chemical is not chronically toxic at 

much lower concentrations than some ratio of the LC50 value would suggest. The results would be 

used to determine the likelihood that the chronic risks can potentially impact aquatic communities, 

either by direct effects on invertebrates or by indirect effects on organisms which feed on them. 

Mysidopsis bahia (for salt water) is used to represent all invertebrate species living in the 

estuarine/marine water column in the risk assessment process. Additionally, the use of the most 

sensitive species ensures the protection of other species within that taxon. As part of the chronic risk 

assessment for aquatic animals, the lowest NOAEC for estuarine/marine invertebrates is used in the 

RQ equation. A chronic LOC is defined by an RQ > 1, and would indicate that there is the potential 

for chronic risk that may warrant regulatory action and that federally listed endangered and threatened 

species may potentially be affected through chronic exposure. 

4) What is triggering the need for this data? 

Data are needed in order to conduct an ecological risk assessment for the use of IPBC as a wood 

preservative and determine the chronic toxicity of IPBC to marine invertebrates using life-cycle 

studies. Also data are needed in order to conduct an ecological risk assessment for material 

preservative use pattern of IPBC. 
21 of 30 

Guideline Number: 850.1400 

Study Title: Fish early-life stage study (using most sensitive species - freshwater or 

estuarine/marine)

Practical Utility of the Data 

1) What is the value of the study? 

Fish early-life stage study is less expensive to conduct than the full life cycle study. Fish early-life 

stage study gives us some indications if the pesticide is toxic to fish reproduction and survival. In the 

fish early-life stage study, fertilized eggs are placed in test chambers and exposed to the pesticide in 

water at least until all the control fish are free-feeding. Lethal and sublethal effects are assessed and 

compared with control values to determine the LOAEC and the NOAEC. 

2) How would the data be used?

The data are used to determine embryo hatch rate, time to hatch, time to swim-up, growth (length and 

weight), and any clinical or pathology findings. 

3) How could the data affect the risk assessment?

As part of the chronic risk assessment for aquatic animals, the lowest NOAEC for estuarine/marine 

fish is used in the RQ equation. A chronic LOC is defined by an RQ > 1, and would indicate that there 

is the potential for chronic risk that may warrant regulatory action and that endangered species may 

potentially be affected through chronic exposure. 

4) What is triggering the need for this data? 

Data are needed in order to conduct an ecological risk assessment for the use of IPBC as an outdoor 

wood preservative and determine the effects of IPBC on fish development and survival during early 

life stages. Also data are needed in order to conduct an ecological risk assessment for material 

preservative use pattern of IPBC.
22 of 30 

Guideline Number: 850.3020 

Study Title: Honeybee acute contact Toxicity 

Guideline Number: 850.3030 

Study Title: Honey Bee Toxicity of Residues on Foliage

Practical Utility of the Data 

1) What is the value of the study?

Pesticide treated wood is sometimes used to make bee hives resulting in bee exposure to pesticide 

residues. The honey bee acute contact toxicity test provides data on the acute toxicity (following a 

single exposure via microapplicator or dusting) followed by a 48-h observation period. 

2) How would the data be used? 

Results of this study will be used to assess risks to honeybees (nontarget insects) from exposure to 

IPBC. Mortality, signs of intoxication, and other abnormal behavior (e.g., ataxia, lethargy, 

hypersensitivity) are reported. The LD50 with 95% confidence interval is calculated from the doseresponse curve data. 

3) How could the data affect the risk assessment? 

Data are needed for future regulatory decisions and for an endangered species assessment in particular. 

There are many terrestrial invertebrates that are listed as threatened and endangered. The data would 

allow the Agency better characterize the potential risk to insects (including beneficial pollinators) from 

the use of IPBC. 

4) What is triggering the need for this data? 

This study has been added to the battery of studies that EPA requires to support outdoor uses when 

honeybees are likely to be exposed to pesticides. The proposed use of IPBC for potential outdoor use 

as a wood preservative would likely allow bees to be exposed to the pesticide. 
23 of 30 

Guideline Number: 850.4400 

Study Title: Aquatic Plant Toxicity Test Using Lemna gibba, Tier II

Practical Utility of the Data 

1) What is the value of the study? 

Aquatic plants are essential components of any healthy ecosystem. Plants provide food, shelter, and 

oxygen to animal species. Lemna represents floating aquatic macrophytes. As part of a Tier II (or Tier 

I) risk assessment, one freshwater aquatic vascular plant indicator species, (Lemna gibba or L. minor), 

is exposed to a range of concentrations of IPBC in fresh water to measure phytotoxicity. 

2) How would the data be used? 

This study would be used to evaluate the toxicity of IPBC to non-target plants in aquatic ecosystems. 

Data from these studies would be used to plot concentration response curves for total frond number, 

growth rate (as number of fronds per day), and mortality (percentage of dead fronds to total number of 

fronds). EC05s, EC50s, and EC90s would be calculated from the curves. Tier II (definitive) testing is 

not required if Tier I testing results in an EC50 greater than 1000 mg/L or less than the analytical 

detection limit. Tier II tests may also include endpoints such as measurements of chlorophyll 

pigments, biomass, and more detailed observations of frond appearance (i.e., decrease in size, necrosis, 

chlorosis, or sinking). 

3) How could the data affect the risk assessment? 

Lemna spp. are used to represent all aquatic plants in the risk assessment process. Adverse effects to 

non-target plants in aquatic ecosystems may result in mitigation to protect species at risk. Mitigation 

might include reduced label dosages, neutralization of effluents prior to discharge into water, 

restrictions on use in sensitive ecosystems or where endangered species are present, or other mitigation 

measures. 

Aquatic plants may be affected where IPBC is used as an outdoor wood preservative. If EPA is unable 

to evaluate the potential risks to aquatic plants associated with the outdoor wood preservative use of 

IPBC, these risks must be presumed. As part of the risk assessment for aquatic vascular plants, the 

lowest EC50 is used in the RQ equation for non-endangered and its paired NOEL is used in the RQ 

equation for endangered species. The LOC for endangered (includes federally threatened species as 

used here) and non-endangered plants is defined as a RQ > 1. 

4) What is triggering the need for this data? 

Data are needed in order to conduct an ecological risk assessment for the use of IPBC as an outdoor 

wood preservative and determine the effects of IPBC on aquatic plants because they are critical to 

ecosystem health and productivity. In addition, aquatic plants may be exposed via indoor uses from 

IPBC used in material preservatives that pass through WWTPs. 
24 of 30 

Guideline Number: 850.5400 

Study Title: Algal Toxicity Test, Tier II (Anabaena flos-aquae, Navicula pelliculosa and 

Selenastrum Capricornutum)

Practical Utility of the Data 

1) What is the value of the study? 

Aquatic plants are essential components of any healthy ecosystem. Plants provide food, shelter, and 

oxygen to animal species. Green algae, blue-green cyanobacterium, and diatoms (marine and 

freshwater), represents thousands of algae species. As part of a Tier II (or Tier I) risk assessment for 

microphytic toxicity, marine diatom (Skeletonema costatum), the freshwater diatom (Navicula 

pelliculosa), and the blue-green alga or cyanobacterium (Anabaena flos-aquae) are tested for 

phytotoxicity. 

2) How would the data be used? 

This study would be used to evaluate the toxicity of IPBC to algae in aquatic ecosystems. The algal 

growth response (number or weight of algal cells/mL) is measured at the end of the 96 h test. The 

percentage inhibition or stimulation of growth for each concentration, concentration response curves, 

and EC50s are determined from these data. Tier II (definitive) testing may not be necessary if the 

highest chemical concentration tested (water saturation concentration or 1000 mg/L) results in less 

than 50% reduction in growth. However, if the lowest concentration tested (analytical detection limit) 

results in greater than a 50% reduction in growth, definitive testing is required. 

3) How could the data affect the risk assessment? 

Because algae are critical to ecosystem health and productivity, any adverse effects to algae in aquatic 

ecosystems may result in mitigation to protect species at risk. Mitigation might include reduced label 

dosages, neutralization of effluents prior to discharge into water, restrictions on use in sensitive 

ecosystems or where endangered species are present, or other mitigation measures. As part of the risk 

assessment for algae, the lowest EC50 is used in the RQ equation for non-endangered and it’s paired 

NOEC for endangered species. The LOC for endangered (includes federally threatened species as used 

here) and non-endangered algae is defined as a RQ > 1. 

4) What is triggering the need for this data? 

Data are needed in order to conduct an ecological risk assessment for the use of IPBC as an outdoor 

wood preservative and determine the effects of IPBC on algae because they are critical to ecosystem 

health and productivity. Also data are needed in order to conduct an ecological risk assessment for 

material preservative use pattern of IPBC and determine the effects of IPBC on algae.
25 of 30 

Appendix C: 

Registered Products of Iodopropynylbutylcarbamate (IPBC) 

Registration # Registration Name Company Name Formulation Type % of Active 

Ingredient 

464-8123 Filmguard IPBC 100 

Fungicidal Agent 

The Dow Chemical 

Co., Soluble Concentrate 98 

464-8124 Filmguard IPBC 40 

Fungicidal Agent 

The Dow Chemical 

Co., Soluble Concentrate 40 

464-8125 Filmguard IPBC 20 

Fungicidal Agent 

The Dow Chemical 

Co. Soluble Concentrate 20 

577-543 Cuprinol Clear Wood 

Preservative 

The SherwinWilliams Co, Ready-to-Use Solution 0.5 

577-547 No. 25 Cuprinol Clear 

Wood Preservative 

The SherwinWilliams Co. Ready-to-Use Solution 0.5 

577-557 Thompson's Wood 

Protector 

The SherwinWilliams Co. Ready-to-Use Solution 0.5 

707-305 Rocima 355 Industrial 

Microbicide Rohm & Haas Co Ready-to-Use Solution 6.5 

1022-516 Permatox IPB IBC Manufacturing 

Co. 

Emulsifiable 

Concentrate 6 

1022-540 IPBC RTU IBC Manufacturing 

Co. Ready-to-Use Solution 0.5 

1022-585 Premier IBC Manufacturing 

Co. Soluble Concentrate 6 

1022-590 Woodguard NC IBC Manufacturing 

Co. Ready-to-Use Solution 0.45 

1022-592 Secure IBC Manufacturing 

Co. Soluble Concentrate 4 

1258-1219 Omacide IPBC 100 Arch Chemicals, 

Inc. Wettable Powder 97 

1258-1220 Omacide IPBC 40 

Industrial Fungicide 

Arch Chemicals, 

Inc. Soluble Concentrate 40 

1258-1221 Omacide IPBC 30 

Industrial Fungicide 

Arch Chemicals, 

Inc. 

Emulsifiable 

Concentrate 30 

1258-1222 Omacide IPBC 20 

Antimicrobial 

Arch Chemicals, 

Inc. 

Emulsifiable 

Concentrate 20 

1258-1225 

Omacide IPBC 100 

(MUP) Industrial 

Fungicide 

Arch Chemicals, 

Inc. 

Technical Chemical 

Manufacturing Use 97 
26 of 30 

Registration # Registration Name Company Name Formulation Type % of Active 

Ingredient 

1258-1230 

Omacide IPBC 30 

DPG Industrial 

Fungicide 

Arch Chemicals, 

Inc. Soluble Concentrate 30 

1258-1236 Omacide IPBC-E Arch Chemicals, 

Inc. Soluble Concentrate 20 

1529-40 Fungitrol 400S 

Fungicide 

International 

Specialty Products 

Technical Chemical 

Manufacturing Use 99.5 

1529-41 Fungitrol(R) 420S 

Fungicide 

International 

Specialty Products Soluble Concentrate 20 

1529-42 Fungitrol 430S 

Fungicide 

International 

Specialty Products Ready-to-Use Solution 30 

1529-43 Fungitrol 440S 

Fungicide 

International 

Specialty Products Ready-to-Use Solution 40 

1529-47 Fungitrol 2010 International 

Specialty Products 

Formulation 

Intermediate 10.1 

1529-50 Fungitrol 400P 

Fungicide 

International 

Specialty Products Technical Chemical 99.5 

1529-51 Fungitrol 400se 

Fungicide 

International 

Specialty Products Ready-to-Use Solution 99.5 

1529-52 Fungitrol 400 PVC 

Fungicide 

International 

Specialty Products Flowable Concentrate 98 

1529-53 Fungitrol 400PE 

Fungicide 

International 

Specialty Products Flowable Concentrate 98 

1529-61 Fungitrol 400G 

Fungicide 

International 

Specialty Products Soluble Concentrate 99.5 

5383-50 Troysan Polyphase P100 

Troy Chemical 

Corp. Ready-to-Use Solution 97 

5383-55 Polyphase AntiMildew WD-17 

Troy Chemical 

Corp. 

Water Dispersible 

Granule 17 

5383-63 Troysan Polyphase AF1

Troy Chemical 

Corp. Soluble Concentrate 40 

5383-74 Troysan Polyphase P-20T Troy Chemical 

Corp. Ready-to-Use Solution 20 

5383-77 Troysan Polyphase AF3

Troy Chemical 

Corp. Ready-to-Use Solution 30 

5383-88 Troysan Polyphase 588 Troy Chemical 

Corp. 

Emulsifiable 

Concentrate 20 

5383-89 Homeguard Troy Chemical Emulsifiable 10 
27 of 30 

Registration # Registration Name Company Name Formulation Type % of Active 

Ingredient 

Corp. Concentrate 

5383-91 Troy Polyphase 604 Troy Chemical 

Corp. Soluble Concentrate 6 

5383-108 Polyphase 662 Troy Chemical 

Corp. Soluble Concentrate 4 

5383-109 Polyphase 663 Troy Chemical 

Corp. 

Water Dispersible 

Granule 3 

5383-110 Polyphase 678 Troy Chemical 

Corp. Soluble Concentrate 5 

5383-112 Polyphase 641 Troy Chemical 

Corp. Ready-to-Use Solution 20 

5383-113 Polyphase CST-1 Troy Chemical 

Corp. 

Emulsifiable 

Concentrate 20 

5383-114 Polyphase HS32 Troy Chemical 

Corp.. Ready-to-Use Solution 21.6 

5383-115 Polyphase 3000 Troy Chemical 

Corp. Soluble Concentrate 28 

5383-116 Polyphase Bionyl A285 Troy Chemical 

Corp. Soluble Concentrate 15 

5383-117 Polyphase 612 Troy Chemical 

Corp. Ready-to-Use Solution 12 

5383-118 Polyphase LA33 Troy Chemical 

Corp. Ready-to-Use Solution 17 

5383-119 Polyphase 685 Troy Chemical 

Corp. Soluble Concentrate 7 

5383-120 Polyphase Micro HS30 Troy Chemical 

Corp. Ready-to-Use Solution 17.4 

5383-132 Polyphase WCI Troy Chemical 

Corp. 

Formulation 

Intermediatem 

Manufacturing Use 

93.9 

5383-133 Troy EX 2085 Troy Chemical 

Corp. 

Emulsifiable 

Concentrate 15 

6836-200 Dantogard Plus 

Industrial Preservative Lonza Inc. Ready-to-Use Solution 4.5 

6836-271 Dantogard Plus Liquid Lonza Inc. Ready-to-Use Solution 2.5 

8177-71 Enterprise Stain & 

Wood Preservative 

The Valspar 

Corporation Ready-to-Use Solution 0.05 
28 of 30 

Registration # Registration Name Company Name Formulation Type % of Active 

Ingredient 

8177-72 Natural Wood 

Preservative 

The Valspar 

Corporation Ready-to-Use Solution 0.63 

8177-73 Enterprise Clear Wood 

Preservative 

Valspar 

Corporation The Ready-to-Use Solution 0.57 

39967-63 Preventol Mp 100 Lanxess 

Corporation Technical Chemical 99.32 

39967-66 Preventol MP 100 

Preservative 

Lanxess 

Corporation Soluble Concentrate 99.32 

39967-75 Preventol MP 400 D Lanxess 

Corporation Soluble Concentrate 39.72 

39967-76 Preventol MP 200 D Lanxess 

Corporation Soluble Concentrate 19.9 

43813-43 Wocosen 450 Janssen PMP Emulsifiable 

Concentrate 16 

43813-44 Wocosen 45 TK Janssen PMP Formulation 

Intermediate 16 

51578-1 

T.W.P. Total Wood 

Preservative - 100 

Clear 

Amteco Inc. Ready-to-Use Solution 0.58 

56601-2 Mildew Check I PPG Industries, Inc. Soluble Concentrate 0.23 

59682-4 Bio-Flex Controlled Release 

Technologies Inc Ready-to-Use Solution 0.157 

60061-27 NP-1 Sapstain Control 

Chemical Kop-Coat, Inc. Soluble Concentrate 7.6 

60061-28 

Wolman(R) F&P 

Premium Wood Finish 

And Preservative 

Kop-Coat, Inc. Ready-to-Use Solution 0.5 

60061-30 Wood Treat MB 

Concentrate Kop-Coat, Inc. Ready-to-Use Solution 2.5 

60061-78 NP-1 Plus Saptain 

Control Chemical Kop-Coat, Inc. Ready-to-Use Solution 7.6 

60061-88 SSCC-3359 Sap Stain 

Control Concentrate Kop-Coat, Inc. Soluble Concentrate 4 

60061-89 Woodlife Milltreat 

Type F VM & P Kop-Coat, Inc. Ready-to-Use Solution 0.5 

60061-90 Woodlife L Water 

Based 5-1 Concentrate Kop-Coat, Inc. Soluble Concentrate 3.09 

60061-91 Woodlife D Kop-Coat, Inc. Soluble Concentrate 2.4 
29 of 30 

Registration # Registration Name Company Name Formulation Type % of Active 

Ingredient 

Concentrate 

60061-93 

Double Diamond 

Sapstain Control 

Chemical 

Kop-Coat, Inc. Soluble Concentrate 3.75 

60061-96 Woodlife Waterbased 

4-1 Concentrate Kop-Coat, Inc. Soluble Concentrate 2.5 

60061-97 Woodlife F Clear 

Wood Preservative Kop-Coat, Inc. Ready-to-Use Solution 0.5 

60061-98 NP-2 Sapstain Control 

Chemical Kop-Coat, Inc. Soluble Concentrate 4.76 

60061-103 Woodlife 111 Kop-Coat, Inc. Ready-to-Use Solution 0.21 

60061-105 Woodlife II Stain And 

Wood Preservative Kop-Coat, Inc. Ready-to-Use Solution 0.5 

60061-109 Woodlife 3 Kop-Coat, Inc. Ready-to-Use Solution 0.1 

60061-112 Bazooka Sapstin And 

Mold Control Product Kop-Coat, Inc. Soluble Concentrate 3.5 

60061-113 LTC-3 Kop-Coat, Inc. Flowable concentrate 2.57 

60061-115 Woodlife 111 4:1 

Concentrate Kop-Coat, Inc. Soluble Concentrate 0.979 

60061-119 Woodlife 111 HP Kop-Coat, Inc. Ready-to-Use Solution .98 

60061-121 Woodtreat XP Sapstain 

Control Product Kop-Coat, Inc. Soluble Concentrate 5 

60061-123 Waterborne Milltreat 

111 Concentrate Kop-Coat, Inc. Soluble Concentrate 1.41 

60061-126 

Workhourse Sapstain 

And Mold Control 

Product 

Kop-Coat, Inc. Soluble Concentrate 1.1 

60061-127 

Moldshield Sapstain 

And Mold Control 

Product 

Kop-Coat, Inc. Soluble Concentrate .7 

60061-133 

Tru-Core Millwork 

Preservative 

Concentrate 

Kop-Coat, Inc. Soluble Concentrate 1.25 

62190-24 Antiblu IP75 Arch Wood 

Protection, Inc. Soluble Concentrate 6 

62190-25 Antiblu XP64 Arch Wood 

Protection, Inc. Soluble Concentrate 6 
30 of 30 

Registration # Registration Name Company Name Formulation Type % of Active 

Ingredient 

62190-33 Antiblu XP32 Arch Wood 

Protection, Inc. Soluble Concentrate 3 

63836-1 

Foster 40-20 

Fungicidal Protective 

Coating 

H.B. Fuller 

Construction 

Products, Inc. 

Ready-to-Use Solution 0.16 

63836-2 

Foster 40-30 

Fungicidal Protective 

Coating 

H.B. Fuller 

Construction 

Products, Inc. 

Ready-to-Use Solution 0.12 

67071-44 Acticide IM Thor GMBH Ready-to-Use Solution 2.5 

67071-53 Acticide MKW1 Thor GMBH Soluble Concentrate 10 

67071-54 Acticide IP 100 Thor GMBH Soluble 

Concentrate/Solid 97 

67071-55 Acticide MKW 2 Thor GMBH Ready-to-Use Solution 10 

67071-60 Acticide IOA Thor GMBH Soluble Concentrate 10 

67071-65 Acticide IPS 20 Thor GMBH Emulsifiable 

Concentrate 20 

67071-66 Acticide IPS 40 Thor GMBH Soluble Concentrate 40 

67071-67 Acticide IPS 50 Thor GMBH Emulcifieable 

Concentrate 40 

69587-2 Woodlife Classic Clear 

Wood Preservative Rust-Oleum Corp Ready-to-Use Solution .5 

69587-4 

Wolman F&P Premium 

Wood Finish & 

Preservative 

Rust-Oleum Corp Ready-to-Use Solution 0.5 

70227-5 Mycostat-K Diacon 

Technologies Ltd. Soluble Concentrate 17 

72616-1 Taratek IP Zelam Ltd. Soluble Concentrate 5