### 2 of 30 IPBC was first registered in the United St ates in 1975 for use as a disinfectant, fungicide, and algaecide. Currently, there are 106 registered products for formulating and end uses. See Appendix C. A Reregistrati on Eligibility Decision (RED) was issued by EPA in March 1997 1



### . The chemical name (IUPAC) for this active ingredient in this registration review case is 3-iodoprop-2-ynyl-N-butylcarbamate (IPBC). Troysan KK-108A is a trade name that refers to a specific product, which is no longer registered, but contained IPBC as an active ingredient. Although the pr evious name for this registration review case is Troysan KK-108A, hence forward this case will be referred to by its chemical name, iodopropynylbutylcarbamate (IPBC).

Use Patterns

Materials Preservatives Adhesives, Industrial (Nonfood Contact) Hides / Leather / Leather Products (Surfaces) Paper (Stored) Textiles / Cordage Products Metalworking Cutting Fluids Coatings, Industrial Specialty Products (Food and Nonfood Contact)

Wood Preservatives Pressure and Non-pressure treatment Sapstain

Science Findings

The Agency has conducted a review of the available product chemistry, environmental fate, and ecotoxicity data for iodopropynylbutylcarbamate (IPBC). The primary source of information for this assessment was the 1997 IPBC RED. The findings are summarized below.

Product Chemistry Summary (TGAI 99.7%)

Common Name: 3-Iodo-2-propynyl-N-butylcarbamate (IPBC); 3-Iodopropynylbutylcarbamate Chemical Name: Carbamic acid, butyl-, 3-iodo-2 propynyl ester CAS Registry Number: 55406-53-6 OPP Chemical Code: 107801 Case: 2725 Molecular Formula: CH 3 

### -(CH 2 

### ) 3 

### -NH-COO-CH 2 

### C ≡ C-I C 8 

### H 12 

### INO 2 

### Trade and Other Names: Troysan Polyphase Anti-Mildew

1 ( http:/www.epa.gov/pesticid es/reregistration/ipbc )

### 3 of 30 Troysan Polyphase KK-108A Troysan KK-108A Permatox IBP ASC 67000 Woodlife

Molecular weight: 281.1 g/mol

Molecular Structure:

Figure 1. Structure of IPBC

Color: Off-white, dull color powder

Physical State: Crystalline Powder

Odor: Sharp pungent odor. Faint odor of iodine; Faint sweet odor

Stability: The substance is: stable at room temperatur e and at 55°C for 14 days, stable on contact with aluminum, aluminum acetate, iron, iron acetate and zinc at 54 °C for 14 days, but unstable on contact with copper, copper acetate and zinc acetate at 54°C for 14 days.

Oxidation/Reduction: N/A. Does not contain an oxi dizing or reducing agent or functional group of significant activity.

Flammability-Flash Point: IPBC is not highly flamma ble. It has no pyrophoric property and it does not under go spontaneous combustion.

Explodability: Not explosive.

Storage Stability: Stable for 12 months at 20-30 °C; chemically and physically stable for a period of 1 year in its commercial container when kept at 25°C and 50% relative humidity.

Miscibility: Miscible with water Corrosion Characteristics: Corrosive to mild steel. Store in Poly containers.

Dielectric breakdown voltage: N/A

### 4 of 30 pH: 7.01 6.1 (1% w/v suspension)

UV/Visible absorption: Maxima at 191 nm and 227 nm

Viscosity: N/A

Melting point: 65 - 66° C.

Boiling Point: N/A

Density: 1.77 gm/cc at 20°C. 1.575 g/mL

Specific Gravity: 1.51 -1.57 at 25°C

Dissociation Constant: Not applicable, non-ionic material.

log P (octanol-water) : log K ow 

### = 2.4/Estimated (EPI Suite) 2.81 at 25°C Log 10 

### P ow 

### = 2.3, P ow 

### =204

Solubilities: In water, 156 mg/L at 20°C (Toxnet); 150 mg/l; 0.168 g/l (pH 7) at 20°C. IPBC is not very water soluble, but is very soluble in methanol (>1000 g/l) and other organic solvents.

Vapor Pressures: <1.8 x 10 -6 

### & 5 x 10 -6 

### mm Hg at 20°C & 30°C, respectively. 5.25 x 10 -5 

### mm Hg at 30° C (Toxnet)

Henry's Law Constants: 8.93 x 10 -9 

### atm-m3/mole at 25°C/Estimated (EPI Suite) 1.2x10 -7 

### atm-cu m/mol at 30°C/Estimated (Toxnet)

Enforcement Analytical Method: HPLC-UV and GC-FID. Methods of analysis for residues are HPLC-MS/MS.

### 5 of 30 All product chemistry data requirements have been satisfied for the active ingredient IPBC. (Sour ce: MRIDs 41722901, 41802501, 42389802, 41802601, 42257901, 43709901, 44721802, 47203402, 47421802, & 44871101)

Environmental Fate Summary

The Agency has reviewed five enviro nmental fate studies for IPBC; the environmental fate guideline study results are summarized in Table 1 and the degradates are listed in Table 2. The Agency's conc lusions for the degradation, metabolism, and mobility studies are as follows.

(1) Degradation Studies (Abiotic)

Hydrolysis

The hydrolysis (guideline 161-1) study provides marginally acceptable data because the study was conducted in non-sterile buffer solutions. The interpretation of the hydrolysis data is not affected by non-sterile conditions because minimal microbial contamination was observed in the buffer solutions.

Radiolabeled IPBC was stable with a half-life of >30 days (k=0.0064 day -1 

### ) in pH 5 buffer solution, had a half-life of 139 days (k= - 0.0049 day -1 

### ) in pH 7 buffer solution, and 0.947 days (k= - 0.732 day 1) in pH 9 buffer solution. Propargyl butyl carbamate (PBC) was identified as the only hydrolysis degradate. The guideline requirement is fulfilled (MRIDs 40947405 & 42329301).

(2) Metabolism Studies

In an Aerobic Soil Metabolism (Guideline 162-1) study, radiolabeled IPBC, at 1
μ g/g, had a half-life of 2.13 hours (k=0.326 hours -1 

### ) in a non-sterile, Blackoar loam soil at 22°C. The half-life of IPBC was 8.60 days (k=0.081 hours -1 

### ) in a nonsterile, Blackoar loam soil at 5°C. The primary degradate of IPBC at both temperatures was identified as PBC (parent compound minus the iodine group) and the half-life of PBC was 4.31 days (k=0.161 days -1 

### ) at 22°C. The degradate PBC further degrades to form CO 2 

### , bound soil residues, and an unidentified metabolite. Th e guideline requirement is fulfilled (MRID 42329302).

Degradation Pathway of IPBC in Aerobic Soil

### 6 of 30 Marginally acceptable data for Anaerobic Soil Metabolism (guideline 162-2 ) and Anaerobic Aquatic Metabolism (Guideline 162-3) were provided. The data are deemed marginally acceptable because low ma terial balances were detected at later sampling intervals. The interpretation of an aerobic aquatic data is not affected by low material balance because supplemental inform ation was provided to quantify and identify non-trappable volatile degradates.

Radiolabeled IPBC, at 6 μ g/g, had a half-life of 1.5 hours (k=0.464 hours -1 

### ) in a nonsterile , static, anaerobic (pe + pH <7) sediment-water test system at 22 °C. The anaerobic aquatic metabolism half-lif e of IPBC was 13.3 hours (k=0.052 hours -1 

### ) in a sterile , static, sediment-water test system. Ra diolabeled residues were predominantly detected (80% of applied IPBC) in the wate r phase of sediment-water systems, and the primary degradate of IPBC was PBC. The half-life of PBC was 11.5 days (k=0.060 days 1 

### ) along with the secondary degradates of IPBC including 2-propenyl-butylcarbamate (2- PBC) and two unidentified compounds. Volatile degradates were identified as PBC, 2- PBC, CO 2 

### and possibly CH 4 

### . The guideline requirement is fulfilled (MRID 42481601).

Degradation Pathway of IPBC in Anaerobic Aquatic Systems



### (3) Mobility Studies

Marginally acceptable data for the unaged portion of the Adsorption/Desorption (Guideline 163-1) data requirement were provided. The data are deemed marginally acceptable because IPBC degradation was obser ved during equilibration, however, the interpretation of m obility is not affected by IPBC de gradation because the Freundlich adsorption coefficients (K ads 

### ) for IPBC are low. Low Freundlich coefficients indicate that any residues of IPBC in the environment ha ve the potential to reach either ground-or surface-water and be associated with water in the presence of soil and sediment. The mobility of IPBC degradates cannot be determ ined at this time because no aged soil column leaching data or batch equilibrium da ta for individual degradates were provided.

Radiolabeled IPBC had K ads 

### values of 0.67 to 2.46 ml/g in a Hanford sandy loam, Centhan sand, Blackoar loam, Mexico silty clay, and an Evesboro sand. Freundlich desorption coefficients (K ads 

### ) ranged from 3.4 to 31 ml/g. Degradation of IPBC was observed in the equilibration solutions. The major degradate of IPBC was PCB. IPBC adsorption was not correlated to organic matter content, clay content, and cation

### 7 of 30 exchange capacity of soil. The guideline requirement is partially fulfilled (MRID 41975207).

In Summary: IPBC is moderately solubl e in water at 127 mg/l (ppm), semivolatile (VP = 4.6 X 10 -4 

### mm Hg), but is unlikely to vol atilize from water based on the Henry's Law Coefficient of 8 .9 x 10 -9 

### atm m 3 

### mole. It has some potential to bioconcentrate in fish based on the Log Kow of 2.45, but is not expected to be significant because the Log Kow (Log P) is <3.

IPBC is stable to hydrolysis at pH 5 (with a half-life of >30 days) and pH 7 with a calculated half-life of 139 days, but is suscepti ble at pH 9 with a half-life of <1 day. The primary degradate was PBC (MRID 42329301). In aerobic soil, the half-lives were 2.1 hours and 8.6 hours at 22 and 5 °C, respect ively. The degradate PBC was formed and degraded to CO 2 

### , bound residues, and an unidentif ied degradate (MRID 42329302). In anaerobic aquatic environments (representing sediment), the half-lives were 1.5 and 13.3 hours under non-sterile and sterile conditions at 22 °C, respectively. As expected parent compound residues were primarily detected in the water phase. PBC degraded with a half-life of 11.5 days under non-sterile conditi ons to form 2-PBC and two unidentified compounds (MRID 42481601). IPBC is mobile to moderately mobile in soil:water systems with K ads 

### values of 0.67 to 2.46 ml/g

. Sorption to soil was not affected by organic matter and clay c ontents of soil (MRID 41975207).

Table 1. Environmental Fate Data Summary for Iodopropynylbutylcarbamate (IPBC)

OPP Guideline Fate Studies Half-Life Degradates Study Status

161-1 Hydrolysis

pH 5

pH 7

pH 9 >30 days (Stable)

139 days (Stable)

<1 day (0.947 d) None

None.

Major degradate : Parent IPBC with the loss of iodine atom (Propargyl butyl carbamate ( PBC)) Supplemental

MRID 40947405 MRID 42329301

162-1 Aerobic Soil Metabolism

IPBC :

Non-Sterile Conditions : Blackoar Loam Soil at 22oC 2.13 hours Major degradates :

PBC Acceptable

MRID 42329302

### 8 of 30 OPP Guideline Fate Studies Half-Life Degradates Study Status

Blackoar Loam Soil at 5oC

SterileConditions :
Blackoar Loam Soil at 22oC

PBC :

Non-Sterile Conditions : Blackoar Loam Soil at 22oC

Blackoar Loam Soil at 5oC: 8.6 hours

Slow degradation of IPBC was also observed in sterile soil.

4.30 days

PBC was more resistant to degradation at 5°C. Mineralization rates were significantly lower at 5°C. PBC

Mineralized to Carbon dioxide (CO 2 )

162-2 Anaerobic Soil Metabolism

IPBC :

Non-Sterile Conditions :
Static Sediment water at 22°C

Sterile Conditions :
Static Sediment water at 22°C

PBC :

Non-Sterile Conditions :
Static Sediment water at 22°C 1.5 hours

13.3 hours

11.5 days Major degradates :

PBC

PBC

2-propenylbutylcarbamate (2-PBC)

Mineralized to CO2 & Me

IPBC and its major degradate PBC should not persist in anaerobic aquatic or anaerobic soils. Acceptable

MRID 42481601

162-3 Anaerobic Aquatic Metabolism DT 50 Major degradates : Acceptable

MRID 42481601

### 9 of 30 OPP Guideline Fate Studies Half-Life Degradates Study Status

IPBC :

Non-Sterile Conditions :
Static Sediment water at 22°C

SterileConditions :
Static Sediment water at 22°C

PBC :

Non-Sterile Conditions :
Static Sediment water at 22°C 1.5 hours

13.3 hours

11.5 days PBC

PBC

2-PBC

2-PBC mineralized to CO2 & Me.

IPBC and its major degradate PBC should not persist in anaerobic aquatic or anaerobic soils.

2 unidentified compounds. 163-1 Leach/Adsorption/Desorption Studies-Batch Equilibrium

Unaged Radiolabeled P-100 had Freundlich adsorption coefficient (K ads ) of 0..67 to 2.46 ml/g in a Hanford sandy loam, Centhan sand, Blackoar loam, Mexico, silty clay, and a Evesboro sand. Freundlich desorption (K des )coefficients ranged from 3.4 to 31 ml/g. Koc ranged from 61 – 309. IPBC is mobile in soil and aquatic environments

Soil Type K ads K des K oc
Sandy Loam 0.676 3.43 90.1

Sand 1.42 18.7 309

Loam 0.976 10.0 61

Silty clay 1.16 31.3 89.2

Sand 2.46 15.6 123 Propargyl butyl carbamate (PBC)

High to moderate mobility based upon Koc values ranging from 62- 310. Acceptable

MRID 41975207

### 10 of 30 Table 2. Degradates of Iodopr opynylbutylcarbamate (IPBC)

IPBC (Parent):

Iodopropynyl butylcarbamate (IPBC) C 8 H 12 INO 2 CAS: 55406-53-6 Molecular Weight: 281.09 

### PBC:

Propargyl butylcarbamate C 8 H 13 NO 2 CAS:76114-73-3 Molecular Weight: 155.19



### 2-PBC:

2-propynyl-butylcarbamate (2-PBC) CAS:76114-73-3 C 8 H 13 NO 2 Molecular Weight: 155.19 

### CO 2 

### & CH 4 

### :

O=C=O & Carbon dioxide & Methane, respectively



### The Agency did not conduct an environmental fate assessment for IPBC because of lack of data. However, the Agency need s to conduct an environmental fate assessment for material preservatives (i ncluding IPBC) that may poten tially pass through waste water treatment plants (WWTPs) and may be discharged into terrestrial and aquatic environments. The Agency also anticipates conducting an environmental fate assessment for IPBC used in wood preservatives. For these assessments the Agency anticipates needing those data outlined on page 15 of this document.

Water Quality

IPBC is not identified as a cause of impairment for any water bodies listed as impaired under section 303(d) of the Clean Water Act, based on information provided at the Agency’s National Pesticides Cause of Im pairment of Waters website (searched April 7, 2011) 2 

### . In addition, no Total Maximum Daily Loads (TMDL) have been developed for IPBC, based on information provided at th e Agency’s National Pesticide TMDL web site (searched April 7, 2011) 3 

### . More information on impaired water bodies and TMDLs can be found at http://www.epa.gov/owow/tmdl/ . The Agency invites submission of water quality data for this pesticide. To the extent possible, data should conform to the quality standards in Appendix A of the OPP Standard Operating Procedure: Inclusion of Impaired Water Body and Other Water Quality Data in OPP’s Registration Review Risk Assessment and Management Process (see: http://www.epa.gov/oppfead1/cb/p pdc/2006/november06/session1-sop.pdf ), in order to ensure they can be used quantitatively or qualitatively in pesticide risk assessments.

2

. http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_group_id=885
3 http://iaspub.epa.gov/tmdl_waters10/attains_nation. tmdl_pollutant_detail?p_pollutant_group_id=885&p_p ollutant_group_name=PESTICIDES

### 11 of 30 Ecological Effects Summary

The Agency has reviewed nineteen ecot oxicology studies and three mammalian toxicity studies for IPBC. The eighteen studies submitted on the 97.2 to 98.7% active ingredient were all found to be acceptable fo r use in a hazard asse ssment. Ecotoxicity guideline studies and the resu lts are summarized in Table 3. The Agency's conclusions for the avian, mammalian, aquatic effects and plant studies are as follows.

Toxicity to Birds Available data indicate that IPBC is slightly toxic to birds on an acute oral basis and practically nontoxic to bird s on a sub-acute dietary basis.

Toxicity to Mammals The Acute Oral LD 50 

### in female rats was 1.1 g/kg with a Toxicity Category of III and indicates slight toxicity.

IPBC did not affect fertility and does not possess significant potential with respect to toxicity to reproduction.

Toxicity to Aquatic Animals On an acute basis, IPBC is highly to very highly toxic to freshwater fish; highly toxic to freshwater invertebrate s; highly toxic to estuarine/ma rine fish and highly to very highly toxic to estuarine/marine invertebrates.

Toxicity to Plants Algal toxicity data indicate that IPBC is detrimental at less than 1.0 ppm to green alga and marine diatom. Therefore, additiona l Tier II (dose response) studies listed on page 15 of this document are required.

Table 3. Ecotoxicity Data Summary for IPBC

MRID COMMON NAME TAXONOMIC NAME GUIDELINE TEST TYPE % AI STUDY TIME DOSE TYPE TOXI CITY TOX LEVEL NOEL Study Status TOX CATEGORY Avian Acute Oral Toxicity

42430901 42623605 Bobwhite quail Colinus virginianus 850.2100 (71-1) O 98.2 14 D LD 50 749 mgk <292 Acceptable Slightly toxic

43491806 Bobwhite quail Colinus virginianus 850.2100 (71-10) O 97.5 21 D LD 50 970 mgk 292 Acceptable Slightly toxic

Avian Subacute Dietary Toxicity

42430902 Bobwhite quail Colinus virginianus 850.2200 (71-2a) D 98.2 8 D LC 50 >3881 ppm 736 Acceptable Practically nontoxic

42430903 Mallard duck Anas
p latyrhynchos 850.2200 (71-2b) D 98.2 8 D LC 50 >5620 ppm 562 Supplemental Practically nontoxic

42623604 Mallard duck Anas
p latyrhynchos 850.2200 (71-2b) D 98.2 8 D LC 50 >5000 ppm 562 Acceptable Practically nontoxic

43491807 Bobwhite quail Colinus virginianus 850.2200 (71-2a) D 97.5 8 D LC 50 >5620 ppm 5620 Acceptable Practically nontoxic

43491808 Mallard duck Anas
p latyrhynchos 850.2200 (71-2b) D 97.5 8 D LC 50 >5620 ppm 5620 Acceptable Practically nontoxic

### 12 of 30 MRID COMMON NAME TAXONOMIC NAME GUIDELINE TEST TYPE % AI STUDY TIME DOSE TYPE TOXI CITY TOX LEVEL NOEL Study Status TOX CATEGORY Freshwater Fish Acute Toxicity

41627107 Rainbow
trout Oncorhynchu s mykiss 850.1075 (72-1) F 97.7 96 hr LC 50 67 ppb 16 Acceptable Very highly toxic

43530209 Rainbow
trout Oncorhynchus mykiss 850.1075 (72-1) F 97.5 96 hr LC 50 72 ppb <22 Supplemental Very highly toxic

41627106 Bluegill sunfish Lepomis macrochirus 850.1075 (72-1) F 97.7 96 hr LC 50 226 ppb 140 Acceptable Highly toxic

43530208 Fathead minnow Pimephales
p romelas 850.1075 (72-1) F 97.5 96 hr LC 50 200 ppb 96 Supplemental Highly toxic

Freshwater Fish Early Life-Stage (Chronic)Toxicity

42389801 Fathead minnow Pimephales
p romelas 850.1400 (72-4a) F 97.25 35 D LOEC

Growth 17.28

17.28 ppb 8.97 Supplemental

MATC: >8.97 and <17.28 ug a.i./l

Geometric Mean MATC = 12.5 ug a.i./l Chronic toxic effects

Freshwater Invertebrate Acute Toxicity

41627108 Water flea Daphnia
magna 850.1010 (72-2) S 98.7 48 hr EC 50 956 ppb 312 Supplemental Highly toxic

43530210 Water flea Daphnia
magna 850.1010 (72-2) F 97.5 48 hr EC 50 160 ppb 76 Acceptable Highly toxic

Daphnid Chronic Toxicity

41975205 42634302 Water flea Daphnia
magna 850.1300 (72-4) F 97 21D EC 50

LOEC 126

99.3 ppb 50 Supplemental

MATC: >50 and <99.3 ug /l

Geometric Mean MATC = 70.4 ug /l Chronic toxic effects

Estuarine/Marine Fish Acute Toxicity

42168203 Sheepshead minnow Cyprinodon variegatus 850.1075 (72-3) F 97.2 96 hr LC 50 418 ppb 140 Acceptable Highly toxic

Estuarine/Marine Oyster Acute Toxicity (Shell-Deposition) - Invertebrates

42168202 Eastern oyster Mollusca Crassostrea virginica 850.1025 (72-3b) F 97.2 96 hr EC 50 23.4 ppb <5.3 Acceptable Very highly toxic

Estuarine/Marine Mysid Acute Toxicity - Invertebrates

42168204 Mysid Crustacea Americamysis bahia 850.1035 (72-3) F 97.2 96 hr LC 50 89.8 ppb 19 Acceptable Very highly toxic Algal Toxicity (Aquatic (Algal) Plant Growth Tier II)

43530211 Green algae Selenastrum capricornutum 850.5400 (123-2) S 97.5 5 D EC 50 100 ppb <89 Acceptable Detrimental effects

Mammalian Acute Oral Toxicity

00148277 Rat 81-1 99 LD 50 LD 50 1.1 (F) 1.5 (M&F) g/kgbw Acceptable Slightly toxic (III)

### 13 of 30 MRID COMMON NAME TAXONOMIC NAME GUIDELINE TEST TYPE % AI STUDY TIME DOSE TYPE TOXI CITY TOX LEVEL NOEL Study Status TOX CATEGORY Mammalian Subchronic Oral Toxicity

40947401 SpragueDawley Rats 82-1 99 13 wks LEL 50 mg/kgbw/ day 20 Supplemental Increased liver to body weight ratio at 125 mg/kg/day
45812301 Rats 870.3100 (82-1) 98 90 days LOAEL 35 mg/kgbw/day 20 Acceptable decreased body weight in males, and salivation and breathing sounds in females
Two-Generation Reproductive Toxicity in Rats

40990402 SpragueDawley Rats 83-4 97 Parental toxicity LEL >37.5 mg/kg

- bw/ day 15 for parental toxicity NOAEL

37.5
for reprodu ctive toxicity NOAEL Acceptable No adverse effects on reproductive indices or mating Performance.

Reduced body weight and food consumption. Decreased mean live birth index.

44478801 Crl:CD (SD)BR VAF Rats 870.3800 (83-4) >97 LOAEL for systemic / reproduc tive toxicity 30 mg/kg -bw/ day 10
for systemic / reprodu ctive toxicity Acceptable Salivation, paddling with both forepaws, and hunched posture; thickened stomach lining; increased ovary weight; reduced food consumption; reduced pup survival; and retardation of pup growth. Oral Developmental Toxicity

40990401 SpragueDawley Rats 83-3 98 LEL

Maternal Toxicity

DevelopMental Toxicity 125

125 mg/kgbw/day

50

50 Acceptable

Reduced body weight gain

Incompletely ossified frontal skull bones and pelvic girdles

42481604 New Zealand white rabbits 83-3 LEL

Maternal Toxicity

DevelopMental Toxicity 50

50 mg/kgbw/day

20

50 Acceptable

Increased mortality, clinical signs, and decreased body weight gain

### 14 of 30 MRID COMMON NAME TAXONOMIC NAME GUIDELINE TEST TYPE % AI STUDY TIME DOSE TYPE TOXI CITY TOX LEVEL NOEL Study Status TOX CATEGORY In-vitro Bacterial Mutageni city Testing (Ames Test)

41975206 Salmonella Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98 and TA100, with and without metabolic activation. 870.5140 84-2(a) 97 Acceptable Nonmutagenic in all five strains with and without metabolic activation at all concentration s tested (1- 1000 μg/plate). Test Type —O: oral; D: dietary; S: static; F: flow-through Tox Level —mgk: milligrams per kilogram-body weigh t; ppm: parts per million (equivalent to milligrams per kilogram-diet (mg/kgdiet) for dietary exposure and milligrams per liter (mg/L) for aquatic exposures); ppb: parts pe r billion (equivalent to microg rams per liter (μg/L) for aquatic exposure) Categories of acute toxicity for aquatic organisms (U.S. EPA, 2004) based on EC 50 /LC 50 (mg/L): < 0. 1 very highly toxic; 0.1-1 highly toxic; >1-10 moderately toxic; >10-100 slightly toxic; >100 practically nontoxic. Toxicity categories for terrestrial pl ants have not been defined. Categories of acute toxicity to terrestrial animals, avian and mammalian (U.S. EPA, 2004). LC 50 (ppm): < 50 very highly toxic; 50 - 500 highly toxic; 501 – 1000 moderately t oxic; 1001-5000 slightly toxic; >5000 practi cally non-toxic. LD50 (mg/kg bw): < 10 v ery highly toxic; 10 - 50 highly toxic; 51 - 500 moderately toxic; 501-2000 sligh tly toxic; >2000 practically non-toxic.



### Ecotoxicity data are adequate to provide the Agency with sufficient information to determine appropriate label precautions.

Adverse Ecological Incidents

There are no reported incidents in the Agency’s Ecological Incident Information System (EIIS) regarding IPBC. The absence of documented incidents does not necessarily mean that such incidents did not occur.

Ecological Effects Risk Assessment

An ecological risk assessment was not conducted on the IPBC’s use patterns described in this document. IPBC uses that have potential for environmental exposure are material preservatives discharges. The Agency anticipates the need to conduct environmental fate and ecological risk assessments for materi al preservatives that potentially pass through waste water treatment plants (WWTPs) and may be discharged into terrestrial and aquatic environments. The Agency also anticipates the need to conduct an ecological risk assessment for the IPBC used in outdoor wood preservatives. For this ecological risk assessment, including an endangered species assessment for all uses, the Agency anticipates needing the ecotoxicity data outlined on page 15 of this document.

The Agency has not conducted a risk assessment for IPBC that supports a complete endangered species effects determination. Th e ecological risk assessment planned during registration review will allow the Agency to de termine whether IPBC’s use has “no effect or “may affect” federally listed threatened or endangered species (listed species) or their designed critical habitats. When an assessment concludes that a pesticide’s use “may affect” a listed species or its designated critical habitat, the Agency will consult with the U.S. Fish and Wildlife Service and/or National Marine Fisheries Services (the Services), as appropriate.

### 15 of 30 Environmental Fate and Ecotoxicity Data Gaps and Anticipated Work

Environmental fate and ecological risk assessments have not been conducted for IPBC. The Agency needs to conduct environmen tal fate and ecological risk assessments for material preservatives th at potentially pass through wa ste water treatment plants (WWTPs) and may be discharged into terrestrial and aquati c environments. The Agency also needs to conduct an ecological risk assessment for IPBC used in outdoor wood preservatives. Therefore, the Agency anticipates needing th e proposed environmental fate and ecotoxicity data for all registered uses of IPBC. The following environmental fate and ecotoxicity data are need ed to conduct an environmental fate and ecological risk
assessments:

• The Agency anticipates needing the following data in order to conduct a complete environmental fate assessment for material preservative uses:

o (GLN 850.6800) Modified activated sludge respiration inhibition

• The Agency anticipates needing th e following ecological effects and environmental fate data in order to conduct a complete ecological risk assessment, including an endangered sp ecies assessment for antisapstain and outdoor wood preservative uses of IPBC:

Anticipated Ecological Effects Data Needs :

o (GLN 850.1350) Mysid Chr onic Toxicity Test;

o (GLN 850.1400) Fish early-lif e stage toxicity test

o (GLN 850.3020) Honeybee Acute Contact Toxicity;

o (GLN 850.3030) Honey Bee Toxicity of Residues on Foliage;

o (GLN 850.4400) Aquatic Plant Toxicity Test Using Lemna gibba, Tier II; and

o (GLN 850.5400) Algal Toxicity Test, Tier II - dose response studies on Anabaena flos- aquae (blue-green cyanobacteria), Navicula pelliculosa (freshwater diatom), and Skelet onema costatum (marine diatom ).

Anticipated Environmental Fate Data Needs :

o (GLN 835.2240) Photodegradation in water;

o (GLN None) (Special study) Leachabili ty of wood preservatives in water contact (AWPA E11-97); and

o (GLN None) (Special study) leacha bility of IPBC from shingles.

### 16 of 30 

## Appendix A. Environmental Fate Guideline Study Justifications Guideline Number: 850.6800; OECD 209 Study Title: Modified Activated Sludge, Resp iration Inhibition Test for Sparingly Soluble Chemicals; Activated Sludge Respiration Inhibition Test Rationale for Requiring the Data An activated sludge, respiration inhi bition test (ASRI) is needed to id entify whether this pesticide could harm activated sludge microorganisms found in biological wastewater treatment systems. The Agency will use these data to determine the potential impact of this chemical on waste water treatment plants (WWTPs) as a result of respiration inhibition of activated sludge microorganisms. This test is also necessary to enable EPA to establish correct concentrations for use in the biodegradability test, if that test is determined to be adequate for assessing biodegradation potential. Furthermore, the results of the Activated Sludge Respiration Inhibition Test (ASRI) de termine which biodegradation test is required. If the ASRI test EC 50 

### is less than or equal to 20 mg/L, then e ither the Biodegradation in Activated Sludge Study or the Porous Pot Test is required. If the ASRI test EC 50 

### is greater than 20 mg/L, then the applicant must choose either: (i) Ready Biodegradability or (ii) Biodegradation in Activated Sludge or the Porous Pot Test. If the antimicrobial passes the ready biodegradabilit y study, then no further testing is required. If, however, the antimicrobial fails the ready biodegrada bility study, then the Biodegradation in Activated Sludge or the Porous Pot study is required.

Practical Utility of the Data 1. How will the data be used? The data will be used to assess potential adverse effects to activated sludge microorganisms. In addition, the data will be used to determine whether or not label restrictions are needed. The st udy will identify the inhibitory effect of this chemical on the treatment plant’s microorganisms’ respiration at different concentrations of the test substance and will identify the EC 50 

### , the effective concentration of the test substance at which the respiration rate is 50% of that shown by the control under conditions in this guideline. The data will also determine suitable non-inhibitory concentrations to be used in biodegradability tests.

2. How could the data impact th e Agency’s future decision-making? If the data indicate a high degree of activated sludge respiration inhibition, a more rigorous test for biodegradation in wastewater treatment will be require d than the ready biodegradability test. Also, if a high degree of respiration inhibition is demonstrated a nd biodegradation and/or sorption is indicated to be negligible, the Agency may require label restrictions or mitigation measures to insure that activated sludge microorganisms will not be adversely impacted.

### 17 of 30 Guideline Number: 835.2240 Study Title: Photodegradation in Water Practical Utility of the Data 1) What is the value of the study? Biocides introduced into aqueous systems in the environment can undergo photolytic transformation by sunlight. Results from the photolysis study will indicate the stability and persistence of IPBC and potential degradates in an aquatic environment when exposed to sunlight. The Agency will evaluate the potential risks of concern.

2) How would the data be used? The data would establish the significance of chem ical photolysis as a route for degradation and identify, if possible, the photolytic degradati on products formed that may adversely affect nontarget organisms and may contaminate water and food source of aquatic organisms. The data would also help establish the photolytic half-life of IPBC and possibly degradates, and assist in developing a degradation pathway.

3) How could the data affect the risk assessment? The results of photolysis data would indicate if IPBC is persistent or if it degrades into degradation products that may adversely affect nontarget organisms and may contaminate their food. The results of the photolysis data would expand the understanding of the results of the hydrolysis data since environmental aquatic c onditions usually involve exposure to sunlight.

4) What is triggering the need for this data? Aqueous photodegradation data is needed to co nduct the fate assessment to support material preservative and wood preservative uses for IPBC.

### 18 of 30 Guideline Number: AWPA E11-06 Study Title: Aquatic leaching study fo r wood preservatives (Special Study) Rationale for Requiring the Data The results from the wood preservative leaching study would allow measurement of the leaching rate of IPBC from treated wood windows, doors, and engineer ed components used in construction application where decay resistance is necessary. The purpose is to provide information on relative permanency of wood preservatives. The method is designed for waterborne preservatives and may not be applicable to other types of preservatives. For outdoor wood preservative uses, IPBC can reach surface water through direct contact or discharge to WWTPs. IPBC can also reach surface water or groundwater through run-off or leaching processes. If IPBC is leached from wood rapi dly, then it may contaminate surface and drinking waters and also have potential adverse effects to non- target organisms and the aquatic environment. The Agency will evaluate the potential risks of concern.

The Agency used a screening level model to asses s potential exposures from wood preservative uses. The model has inherent uncertainties and limitations wh ich may result in inaccurate exposure estimations. Therefore, the wood leaching rate data are requi red to conduct an environmental risk assessment. 

### Practical Utility of the Data

1. How will the data be used? EPA will use the data to conduct the ecological effects and environmental fate assessments to determine the leachability of wood preservatives expressed as a percentage of the original preservative retention and to determine whether the ion levels in the leachate would be of toxicological concern. The amount of preservative leached is expressed as the ratio of the preservative contained in the leachate to the total preservative present.

2. How could the data impact th e Agency’s future decision-making? This data is necessary for the Agency to accurately estimate potential environmental exposures and risks without which the Agency would assume the highest ava ilable leaching, resulting in the highest levels of environmental exposure and risk. Thus, the lack of these data could result in use restrictions for IPBC which are unnecessarily severe. Determination of appropr iate risk mitigation measures is dependent on the results of these data.

If future endangered species risk assessments are perfo rmed without these data, the Agency would have to assume that IPBC “may affect” non-target organisms di rectly (and endangered species indirectly), and use of IPBC may need to be restricted in areas where endangered species could be exposed.

By refining the assessment, the Agency would be able to determine whether the mitigation imposed as part of the registration review process was appropriate fo r IPBC. The data evaluation could result in either additional or reduced environmental risk mitigation measures.

### 19 of 30 Guideline Number: Special Study Study Title: Leachability of IPBC from Roofing Shingles Rationale for Requiring the Data
Studies are needed to conduct environmental fate a nd ecological effects assessments and to determine the leachability of IPBC expressed as a percentage of th e original preservative retention; and to confirm that ion levels in the leachate woul d be of no toxico logical concern. 

### Practical Utility of the Data

2. How will the data be used? EPA will use the data to determine the leachability of IPBC expressed as a percentage of the original preservative retention. The amount of preservative l eached is expressed as the ratio of the preservative contained in the leachate to the total preserva tive present. Study provides data to assess the environmental leaching characteristic of shingles impregnated or coated with IPBC.

2. How could the data impact th e Agency’s future decision-making? If future endangered species risk assessments are pe rformed without these data, the Agency would have to assume that IPBC “may affect” non-target organisms directly (and endangered species indirectly), and use of IPBC may need to be restricted in areas where endangered species could be exposed. The lack of these data will limit the flexibility the Agen cy and registrants have in coming into compliance with the Endangered Species Act and could result in use restrictions for IPBC which are unnecessarily

severe.

Also, extrapolating risk conclusions used in the environmental modeling may either underestimate or overestimate potential exposures and risks. Such leaching data would be useful in refining the preliminary risk assessment and determining wh ether the Agency’s assessment is an accurate estimation of potential exposures and risks. Risk mitigation measures may also be impacted by the results of these data.

By refining the assessment, the Agency would be ab le to determine whether the mitigation imposed as part of the registration review process was appropria te for IPBC. The data evaluation could result in additional or reduced environmental risk mitigation measures.

### 20 of 30 

## Appendix B: Ecological Guideline Study Justifications Guideline Number: 850.1350 Study Title: Mysid Chronic Toxicity Test Practical Utility of the Data 1) What is the value of the study? Invertebrates serve as food for fish, birds, crustaceans, and even whales. The protection of non-target invertebrates is essential to the food chain in any healthy ecosystem. The value in the Mysid (850.1350) chronic toxicity test is that it provides information on the effects of pesticides on mortality, growth, and reproduction over a longer term (28 days for Mysids) compared to acute studies. Data are obtained from the first generation (G1) and the sec ond generation (G2), thus allowing examination of the complete invertebrate life cycle for toxicity.

2) How would the data be used? Data would be used to calculate LC 50 

### ’s for mortality, EC 50 

### ’s for growth, a NOAEC, and a MATC (maximum acceptable toxicant concentration). The da ta would allow the Agency to determine chronic effects, including effects on reproductive success an d growth, to marine invertebrates from water column exposure to IPBC.

3) How could the data affect the risk assessment? Because acute toxicity data alone are not a reliable i ndicator of chronic toxicity, chronic toxicity data are also required. The Agency cannot make the assump tion that a chemical is not chronically toxic at much lower concentrations than some ratio of the LC 50 

### value would suggest. The results would be used to determine the likelihood that the chroni c risks can potentially imp act aquatic communities, either by direct effects on invertebrates or by indirect effects on organisms which feed on them. Mysidopsis bahia (for salt water) is used to represent a ll invertebrate species living in the estuarine/marine water column in the risk assessmen t process. Additionally, the use of the most sensitive species ensures the protecti on of other species within that taxon. As part of the chronic risk assessment for aquatic animals, the lowest NOAEC fo r estuarine/marine invertebrates is used in the RQ equation. A chronic LOC is defined by an RQ > 1, and would indicate that there is the potential for chronic risk that may warrant regulatory action an d that federally listed e ndangered and threatened species may potentially be affected through chronic exposure.

4) What is triggering the need for this data? Data are needed in order to conduct an ecologi cal risk assessment for the use of IPBC as a wood preservative and determine the chronic toxicity of IPBC to marine invertebrates using life-cycle studies. Also data are needed in order to c onduct an ecological risk assessment for material preservative use pattern of IPBC.

### 21 of 30 Guideline Number: 850.1400 Study Title: Fish early-life stage study (u sing most sensitive species - freshwater or estuarine/marine) Practical Utility of the Data 1) What is the value of the study? Fish early-life stage study is less expensive to cond uct than the full life cycle study. Fish early-life stage study gives us some indications if the pesticid e is toxic to fish reproduction and survival. In the fish early-life stage study, fertilized eggs are placed in test chambers and exposed to the pesticide in water at least until all the control fi sh are free-feeding. Lethal and sublethal effects are assessed and compared with control values to determine the LOAEC and the NOAEC.

2) How would the data be used? The data are used to determine embryo hatch rate, tim e to hatch, time to swim-up, growth (length and weight), and any clinical or pathology findings.

3) How could the data affect the risk assessment? As part of the chronic risk assessment for aquatic animals, the lowest NOAEC for estuarine/marine fish is used in the RQ equation. A chronic LOC is defined by an RQ > 1, and would indicate that there is the potential for chronic risk that may warrant regulatory action and that endangered species may potentially be affected through chronic exposure.

4) What is triggering the need for this data? Data are needed in order to conduct an ecological risk assessment for the use of IPBC as an outdoor wood preservative and determine the effects of IPBC on fish development and survival during early life stages. Also data are needed in order to c onduct an ecological risk assessment for material preservative use pattern of IPBC.

### 22 of 30 Guideline Number: 850.3020 Study Title: Honeybee acute contact Toxicity

Guideline Number: 850.3030 Study Title: Honey Bee Toxi city of Residues on Foliage Practical Utility of the Data 1) What is the value of the study? Pesticide treated wood is sometimes used to make bee hives resulting in bee exposure to pesticide residues. The honey bee acute contact toxicity test provides data on the acute toxicity (following a single exposure via microapplicator or dusting) followed by a 48-h observation period.

2) How would the data be used? Results of this study will be used to assess risk s to honeybees (nontarget insects) from exposure to IPBC. Mortality, signs of intoxication, and ot her abnormal behavior (e.g., ataxia, lethargy, hypersensitivity) are reported. The LD 50 

### with 95% confidence interval is calculated from the doseresponse curve data.

3) How could the data affect the risk assessment? Data are needed for future regulatory decisions and for an endangered species assessment in particular. There are many terrestrial invertebrates that are listed as threatened and endangered. The data would allow the Agency better characterize the potential risk to insects (including beneficial pollinators) from the use of IPBC.

4) What is triggering the need for this data? This study has been added to the battery of st udies that EPA requires to support outdoor uses when honeybees are likely to be exposed to pesticides. The proposed use of IPBC for potential outdoor use as a wood preservative would likely allow b ees to be exposed to the pesticide.

### 23 of 30 Guideline Number: 850.4400 Study Title: Aquatic Plant Toxicity Test Using Lemna gibba , Tier II Practical Utility of the Data 1) What is the value of the study? Aquatic plants are essential components of any health y ecosystem. Plants provide food, shelter, and oxygen to animal species. Lemna represents floating aquatic macrophytes. As part of a Tier II (or Tier I) risk assessment, one freshwater aquatic vascular plant indicator species, ( Lemna gibba or L. minor ), is exposed to a range of concentrations of IPBC in fresh water to measure phytotoxicity.

2) How would the data be used? This study would be used to evaluate the toxicity of IPBC to non-target plants in aquatic ecosystems. Data from these studies would be used to plot concentration response curves for total frond number, growth rate (as number of fronds per day), and morta lity (percentage of dead fronds to total number of fronds). EC 05 

### s, EC 50 

### s, and EC 90 

### s would be calculated from the curves. Tier II (definitive) testing is not required if Tier I testing results in an EC 50 

### greater than 1000 mg/L or less than the analytical detection limit. Tier II tests may also include endpoints such as measurements of chlorophyll pigments, biomass, and more deta iled observations of frond appearance (i.e., decrease in size, necrosis, chlorosis, or sinking).

3) How could the data affect the risk assessment? Lemna spp. are used to represent all aquatic plants in the risk assessment process. Adverse effects to non-target plants in aquatic ecosystems may result in mitigation to protect species at risk. Mitigation might include reduced label dosages, neutralization of effluents prior to discharge into water, restrictions on use in sensitive ecosystems or where endangered species are present, or other mitigation

measures.

Aquatic plants may be affected where IPBC is used as an outdoor wood preservative. If EPA is unable to evaluate the potential risks to aquatic plants associated with the outdoor wood preservative use of IPBC, these risks must be presumed. As part of the risk assessment for aquatic vascular plants, the lowest EC 50 

### is used in the RQ equation for non-endangere d and its paired NOEL is used in the RQ equation for endangered species. The LOC for endange red (includes federally threatened species as used here) and non-endangered plants is defined as a RQ > 1.

4) What is triggering the need for this data?

Data are needed in order to conduct an ecological risk assessment for the use of IPBC as an outdoor wood preservative and determine the effects of IPBC on aquatic plants because they are critical to ecosystem health and productivity. In addition, aquatic plants may be exposed via indoor uses from IPBC used in material preservatives that pass through WWTPs.

### 24 of 30 Guideline Number: 850.5400 Study Title: Algal Toxicity Test, Tier II ( Anabaena flos-aquae, Navicula pelliculosa and Selenastrum Capricornutum) Practical Utility of the Data 1) What is the value of the study? Aquatic plants are essential components of any health y ecosystem. Plants provide food, shelter, and oxygen to animal species. Green algae, blue -green cyanobacterium, and diatoms (marine and freshwater), represents thousands of algae species. As part of a Tier II (or Tier I) risk assessment for microphytic toxicity, marine diatom ( Skeletonema costatum ), the freshwater diatom ( Navicula pelliculosa ), and the blue-green alga or cyanobacterium ( Anabaena flos-aquae ) are tested for phytotoxicity.

2) How would the data be used? This study would be used to evaluate the toxicity of IPBC to algae in aquatic ecosystems. The algal growth response (number or weight of algal cells/mL) is measured at the end of the 96 h test. The percentage inhibition or stimulation of growth fo r each concentration, concentration response curves, and EC 50 

### s are determined from these data. Tier II (d efinitive) testing may not be necessary if the highest chemical concentration tested (water satur ation concentration or 1000 mg/L) results in less than 50% reduction in growth. However, if the low est concentration tested (analytical detection limit) results in greater than a 50% reduction in growth, definitive testing is required.

3) How could the data affect the risk assessment? Because algae are critical to ecosystem health and pr oductivity, any adverse effects to algae in aquatic ecosystems may result in mitigation to protect species at risk. Mitigation might include reduced label dosages, neutralization of effluents prior to dischar ge into water, restrictions on use in sensitive ecosystems or where endangered species are present, or other mitigation measures. As part of the risk assessment for algae, the lowest EC 50 

### is used in the RQ equation for non-endangered and it’s paired NOEC for endangered species. The LOC for endangered (includes federally th reatened species as used here) and non-endangered algae is defined as a RQ > 1.

4) What is triggering the need for this data? Data are needed in order to conduct an ecological risk assessment for the use of IPBC as an outdoor wood preservative and determine the effects of IPBC on algae because they are critical to ecosystem health and productivity. Also data are needed in order to conduct an ecological risk assessment for material preservative use pattern of IPBC and determine the effects of IPBC on algae.

### 25 of 30 

# Appendix C:

Registered Products of Iodopr opynylbutylcarbamate (IPBC)

Registration # Registration Name Company Name Formulation Type % of Active Ingredient

464-8123 Filmguard IPBC 100 Fungicidal Agent The Dow Chemical Co., Soluble Concentrate 98

464-8124 Filmguard IPBC 40 Fungicidal Agent The Dow Chemical Co., Soluble Concentrate 40

464-8125 Filmguard IPBC 20 Fungicidal Agent The Dow Chemical Co. Soluble Concentrate 20

577-543 Cuprinol Clear Wood Preservative The SherwinWilliams Co, Ready-to-Use Solution 0.5

577-547 No. 25 Cuprinol Clear Wood Preservative The SherwinWilliams Co. Ready-to-Use Solution 0.5

577-557 Thompson's Wood Protector The SherwinWilliams Co. Ready-to-Use Solution 0.5

707-305 Rocima 355 Industrial Microbicide Rohm & Haas Co Ready-to-Use Solution 6.5

1022-516 Permatox IPB IBC Manufacturing Co. Emulsifiable Concentrate 6

1022-540 IPBC RTU IBC Manufacturing Co. Ready-to-Use Solution 0.5

1022-585 Premier IBC Manufacturing Co. Soluble Concentrate 6

1022-590 Woodguard NC IBC Manufacturing Co. Ready-to-Use Solution 0.45

1022-592 Secure IBC Manufacturing Co. Soluble Concentrate 4

1258-1219 Omacide IPBC 100 Arch Chemicals, Inc. Wettable Powder 97

1258-1220 Omacide IPBC 40 Industrial Fungicide Arch Chemicals, Inc. Soluble Concentrate 40

1258-1221 Omacide IPBC 30 Industrial Fungicide Arch Chemicals, Inc. Emulsifiable Concentrate 30

1258-1222 Omacide IPBC 20 Antimicrobial Arch Chemicals, Inc. Emulsifiable Concentrate 20

1258-1225 Omacide IPBC 100 (MUP) Industrial Fungicide Arch Chemicals, Inc. Technical Chemical Manufacturing Use 97

### 26 of 30 Registration # Registration Name Company Name Formulation Type % of Active Ingredient

1258-1230 Omacide IPBC 30 DPG Industrial Fungicide Arch Chemicals, Inc. Soluble Concentrate 30

1258-1236 Omacide IPBC-E Arch Chemicals, Inc. Soluble Concentrate 20

1529-40 Fungitrol 400S Fungicide International Specialty Products Technical Chemical Manufacturing Use 99.5

1529-41 Fungitrol(R) 420S Fungicide International Specialty Products Soluble Concentrate 20

1529-42 Fungitrol 430S Fungicide International Specialty Products Ready-to-Use Solution 30

1529-43 Fungitrol 440S Fungicide International Specialty Products Ready-to-Use Solution 40

1529-47 Fungitrol 2010 International Specialty Products Formulation Intermediate 10.1

1529-50 Fungitrol 400P Fungicide International Specialty Products Technical Chemical 99.5

1529-51 Fungitrol 400se Fungicide International Specialty Products Ready-to-Use Solution 99.5

1529-52 Fungitrol 400 PVC Fungicide International Specialty Products Flowable Concentrate 98

1529-53 Fungitrol 400PE Fungicide International Specialty Products Flowable Concentrate 98

1529-61 Fungitrol 400G Fungicide International Specialty Products Soluble Concentrate 99.5

5383-50 Troysan Polyphase P100 Troy Chemical Corp. Ready-to-Use Solution 97

5383-55 Polyphase AntiMildew WD-17 Troy Chemical Corp. Water Dispersible Granule 17

5383-63 Troysan Polyphase AF1 Troy Chemical Corp. Soluble Concentrate 40

5383-74 Troysan Polyphase P-20T Troy Chemical Corp. Ready-to-Use Solution 20

5383-77 Troysan Polyphase AF3 Troy Chemical Corp. Ready-to-Use Solution 30

5383-88 Troysan Polyphase 588 Troy Chemical Corp. Emulsifiable Concentrate 20

5383-89 Homeguard Troy Chemical Emulsifiable 10

### 27 of 30 Registration # Registration Name Company Name Formulation Type % of Active Ingredient

Corp. Concentrate

5383-91 Troy Polyphase 604 Troy Chemical Corp. Soluble Concentrate 6

5383-108 Polyphase 662 Troy Chemical Corp. Soluble Concentrate 4

5383-109 Polyphase 663 Troy Chemical Corp. Water Dispersible Granule 3

5383-110 Polyphase 678 Troy Chemical Corp. Soluble Concentrate 5

5383-112 Polyphase 641 Troy Chemical Corp. Ready-to-Use Solution 20

5383-113 Polyphase CST-1 Troy Chemical Corp. Emulsifiable Concentrate 20

5383-114 Polyphase HS32 Troy Chemical Corp.. Ready-to-Use Solution 21.6

5383-115 Polyphase 3000 Troy Chemical Corp. Soluble Concentrate 28

5383-116 Polyphase Bionyl A285 Troy Chemical Corp. Soluble Concentrate 15

5383-117 Polyphase 612 Troy Chemical Corp. Ready-to-Use Solution 12

5383-118 Polyphase LA33 Troy Chemical Corp. Ready-to-Use Solution 17

5383-119 Polyphase 685 Troy Chemical Corp. Soluble Concentrate 7

5383-120 Polyphase Micro HS30 Troy Chemical Corp. Ready-to-Use Solution 17.4

5383-132 Polyphase WCI Troy Chemical Corp. Formulation Intermediatem Manufacturing Use 93.9

5383-133 Troy EX 2085 Troy Chemical Corp. Emulsifiable Concentrate 15

6836-200 Dantogard Plus Industrial Preservative Lonza Inc. Ready-to -Use Solution 4.5

6836-271 Dantogard Plus Liquid Lonza Inc. Ready-to-Use Solution 2.5

8177-71 Enterprise Stain & Wood Preservative The Valspar Corporation Ready-to-Use Solution 0.05

### 28 of 30 Registration # Registration Name Company Name Formulation Type % of Active Ingredient

8177-72 Natural Wood Preservative The Valspar Corporation Ready-to-Use Solution 0.63

8177-73 Enterprise Clear Wood Preservative Valspar Corporation The Ready-to-Use Solution 0.57

39967-63 Preventol Mp 100 Lanxess Corporation Technical Chemical 99.32

39967-66 Preventol MP 100 Preservative Lanxess Corporation Soluble Concentrate 99.32

39967-75 Preventol MP 400 D Lanxess Corporation Soluble Concentrate 39.72

39967-76 Preventol MP 200 D Lanxess Corporation Soluble Concentrate 19.9

43813-43 Wocosen 450 Janssen PMP Emulsifiable Concentrate 16

43813-44 Wocosen 45 TK Janssen PMP Formulation Intermediate 16

51578-1 T.W.P. Total Wood Preservative - 100 Clear Amteco Inc. Ready-to-Use Solution 0.58

56601-2 Mildew Check I PPG Industri es, Inc. Soluble Concentrate 0.23

59682-4 Bio-Flex Controlled Release Technologies Inc Ready-to-Use Solution 0.157

60061-27 NP-1 Sapstain Control Chemical Kop-Coat, Inc. Soluble Concentrate 7.6

60061-28 Wolman(R) F&P Premium Wood Finish And Preservative Kop-Coat, Inc. Ready- to-Use Solution 0.5

60061-30 Wood Treat MB Concentrate Kop-Coat, Inc. Ready- to-Use Solution 2.5

60061-78 NP-1 Plus Saptain Control Chemical Kop-Coat, Inc. Ready- to-Use Solution 7.6

60061-88 SSCC-3359 Sap Stain Control Concentrate Kop-Coat, Inc. Soluble Concentrate 4

60061-89 Woodlife Milltreat Type F VM & P Kop-Coat, Inc. Ready- to-Use Solution 0.5

60061-90 Woodlife L Water Based 5-1 Concentrate Kop-Coat, Inc. Soluble Concentrate 3.09

60061-91 Woodlife D Kop-Coat, Inc. Soluble Concentrate 2.4

### 29 of 30 Registration # Registration Name Company Name Formulation Type % of Active Ingredient

Concentrate

60061-93 Double Diamond Sapstain Control Chemical Kop-Coat, Inc. Soluble Concentrate 3.75

60061-96 Woodlife Waterbased 4-1 Concentrate Kop-Coat, Inc. Soluble Concentrate 2.5

60061-97 Woodlife F Clear Wood Preservative Kop-Coat, Inc. Ready- to-Use Solution 0.5

60061-98 NP-2 Sapstain Control Chemical Kop-Coat, Inc. Soluble Concentrate 4.76

60061-103 Woodlife 111 Kop-Coat, Inc. Ready-to-Use Solution 0.21

60061-105 Woodlife II Stain And Wood Preservative Kop-Coat, Inc. Ready- to-Use Solution 0.5

60061-109 Woodlife 3 Kop-Coat, Inc. Ready-to-Use Solution 0.1

60061-112 Bazooka Sapstin And Mold Control Product Kop-Coat, Inc. Soluble Concentrate 3.5

60061-113 LTC-3 Kop-Coat, Inc. Flowable concentrate 2.57

60061-115 Woodlife 111 4:1 Concentrate Kop-Coat, Inc. Soluble Concentrate 0.979

60061-119 Woodlife 111 HP Kop-Coat, Inc. Ready-to-Use Solution .98

60061-121 Woodtreat XP Sapstain Control Product Kop-Coat, Inc. Soluble Concentrate 5

60061-123 Waterborne Milltreat 111 Concentrate Kop-Coat, Inc. Soluble Concentrate 1.41

60061-126 Workhourse Sapstain And Mold Control Product Kop-Coat, Inc. Soluble Concentrate 1.1

60061-127 Moldshield Sapstain And Mold Control Product Kop-Coat, Inc. Solu ble Concentrate .7

60061-133 Tru-Core Millwork Preservative Concentrate Kop-Coat, Inc. Soluble Concentrate 1.25

62190-24 Antiblu IP75 Arch Wood Protection, Inc. Soluble Concentrate 6

62190-25 Antiblu XP64 Arch Wood Protection, Inc. Soluble Concentrate 6

### 30 of 30 Registration # Registration Name Company Name Formulation Type % of Active Ingredient

62190-33 Antiblu XP32 Arch Wood Protection, Inc. Soluble Concentrate 3

63836-1 Foster 40-20 Fungicidal Protective Coating H.B. Fuller Construction Products, Inc. Ready-to-Use Solution 0.16

63836-2 Foster 40-30 Fungicidal Protective Coating H.B. Fuller Construction Products, Inc. Ready-to-Use Solution 0.12

67071-44 Acticide IM Thor GMBH Ready-to-Use Solution 2.5

67071-53 Acticide MKW1 Thor GMBH Soluble Concentrate 10

67071-54 Acticide IP 100 Thor GMBH Soluble Concentrate/Solid 97

67071-55 Acticide MKW 2 Thor GMBH Ready-to-Use Solution 10

67071-60 Acticide IOA Thor GMBH Soluble Concentrate 10

67071-65 Acticide IPS 20 Thor GMBH Emulsifiable Concentrate 20

67071-66 Acticide IPS 40 Thor GMBH Soluble Concentrate 40

67071-67 Acticide IPS 50 Thor GMBH Emulcifieable Concentrate 40

69587-2 Woodlife Classic Clear Wood Preservative Rust-Oleum Corp Ready-to-Use Solution .5

69587-4 Wolman F&P Premium Wood Finish & Preservative Rust-Oleum Corp Ready-to-Use Solution 0.5

70227-5 Mycostat-K Diacon Technologies Ltd. Soluble Concentrate 17

72616-1 Taratek IP Zelam Ltd. Soluble Concentrate 5