Federal Register / Vol. 74, No. 71 / Wednesday, April 15, 2009 / Notices 17579 

respondent burden is 1,003 hours, and 

the cost is $70,790. The total annualized 

estimated paperwork burden for this 

ICR is 108,364 hours, with an estimated 

total annual cost of $7,478,116 million. 

Although individual respondent burden 

varies based on their individual 

activities, this estimate assumes that the 

respondent actively participates in all 

potential activities, including 

developing consortia, generating all of 

the potential data, submitting a progress 

report, requesting an extension, and 

submitting the data. 

Pursuant to 5 CFR 1320.12, the 

submission of the ICR to OMB, along 

with a solicitation of comments on that 

ICR, is addressed in a separate 

document published elsewhere in 

today’s Federal Register. Please follow 

the instructions in that document to 

view the ICR and submit comments on 

the revised ICR. 

VI. References 

The following is a list of the 

documents that are specifically 

referenced in this document and placed 

in the docket that was established under 

Docket ID number EPA–HQ–OPPT– 

2007–1080. For information on 

accessing the docket, refer to the 

ADDRESSES unit at the beginning of this 

document. 

1. EPA. Endocrine Disruptor 

Screening and Testing Advisory 

Committee (EDSTAC) Final Report. 

August 1998. http://www.epa.gov/ 

scipoly/oscpendo/pubs/edspoverview/ 

finalrpt.htm. 

2. Organization for Economic 

Cooperation and Development (OECD). 

Final Report of the OECD Workshop on 

Harmonization of Validation and 

Acceptance Criteria for Alternative 

Toxicological Test Methods. August 

1996. 

3. EPA. Response to Comments on the 

Endocrine Disruptor Screening Program: 

Draft Policies and Procedures for Initial 

Screening and Testing. March 2009. 

4. EPA. EPA’s Approach for 

Considering Other Scientifically 

Relevant Information (OSRI) under the 

Endocrine Disruptor Screening Program. 

March 17, 2009. 

List of Subjects 

Environmental protection, Chemicals, 

Endocrine disruptors, Pesticides and 

pests, Reporting and recordkeeping. 

Dated: April 3, 2009. 

James Jones, 

Acting Assistant Administrator for 

Prevention, Pesticides and Toxic Substances. 

[FR Doc. E9–8706 Filed 4–14–09; 8:45 am] 

BILLING CODE 6560–50–S 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPPT–2004–0109; FRL–8399–7] 

Final List of Initial Pesticide Active 

Ingredients and Pesticide Inert 

Ingredients to be Screened Under the 

Federal Food, Drug, and Cosmetic Act 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: Section 408(p) of the Federal 

Food, Drug, and Cosmetic Act (FFDCA) 

directs EPA to develop a chemical 

screening program using appropriate 

validated test systems and other 

scientifically relevant information to 

determine whether certain substances 

may have hormonal effects. In 

September 2005, EPA published its 

approach for selecting the initial list of 

chemicals for which testing will be 

required under the Endocrine Disruptor 

Screening Program (EDSP) and in June 

2007, EPA published the draft list of the 

first group of chemicals proposed for 

screening in the Agency’s EDSP. This 

document presents the final list of the 

first group of chemicals that will be 

screened in the Agency’s EDSP. The list 

was produced using the approach 

described in the September 2005 notice 

and considers comments received in 

response to the June 2007 draft list. The 

list includes chemicals that the Agency, 

in its discretion, has decided should be 

tested first, based upon exposure 

potential. The Agency deleted 6 

chemicals from the original list of 73 

based upon recent information showing 

that the chemicals are no longer 

expected to be found in 3 exposure 

pathways. The first group of 67 

chemicals identified for testing includes 

pesticide active ingredients and High 

Production Volume (HPV) chemicals 

used as pesticide inert ingredients (also 

known as other ingredients). This list 

should not be construed as a list of 

known or likely endocrine disruptors. 

Nothing in the approach for generating 

the initial list provides a basis to infer 

that by simply being on this list these 

chemicals are suspected to interfere 

with the endocrine systems of humans 

or other species, and it would be 

inappropriate to do so. This document 

does not describe other aspects of the 

EDSP such as the administrative 

procedures EPA will use to require 

testing, which is addressed in a separate 

notice published in today’s Federal 

Register. 

FOR FURTHER INFORMATION CONTACT: 

Linda Phillips, Office of Science 

Coordination and Policy (7203M), 

Environmental Protection Agency, 1200 

Pennsylvania Ave., NW., Washington, 

DC 20460–0001; telephone number: 

(202) 564–1264; e-mail address: 

phillips.linda@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. General Information 

A. Does this Action Apply to Me? 

This action is directed to the public 

in general. You may be potentially 

affected by this action if you produce, 

manufacture, use, consume, work with, 

or import pesticide chemicals. To 

determine whether you or your business 

may be affected by this action, you 

should carefully examine section 408(p) 

of FFDCA, 21 U.S.C. 346a(p). Potentially 

affected entities, using the North 

American Industrial Classification 

System (NAICS) codes to assist you and 

others in determining whether this 

action might apply to certain entities, 

may include, but are not limited to: 

• Chemical manufacturers, importers 

and processors (NAICS code 325), e.g., 

persons who manufacture, import or 

process chemical substances. 

• Pesticide, fertilizer, and other 

agricultural chemical manufacturers 

(NAICS code 3253), e.g., persons who 

manufacture, import or process 

pesticide, fertilizer and agricultural 

chemicals. 

• Scientific research and 

development services (NAICS code 

5417), e.g., persons who conduct testing 

of chemical substances for endocrine 

effects. 

This listing is not intended to be 

exhaustive, but rather provides a guide 

for readers regarding entities likely to be 

affected by this action. Other types of 

entities not listed in this unit could also 

be affected. If you have any questions 

regarding the applicability of this action 

to a particular entity, consult the person 

listed under FOR FURTHER INFORMATION

CONTACT. 

B. How Can I Get Copies of this 

Document and Other Related 

Information? 

1. Docket. EPA has established a 

docket for this action under docket 

identification (ID) number EPA–HQ– 

OPPT–2004–0109. All documents in the 

docket are listed in the docket index 

available in regulations.gov. To access 

the electronic docket, go to http:// 

www.regulations.gov, select ‘‘Advanced 

Search,’’ then ‘‘Docket Search.’’ Insert 

the docket ID number where indicated 

and select the ‘‘Submit’’ button. Follow 

the instructions on the regulations.gov 

website to view the docket index or 

access available documents. Although 

listed in the index, some information is 


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not publicly available, e.g., Confidential 

Business Information (CBI) or other 

information whose disclosure is 

restricted by statute. Certain other 

material, such as copyrighted material, 

will be publicly available only in hard 

copy. Publicly available docket 

materials are available electronically at 

http://www.regulations.gov, or, if only 

available in hard copy, at the OPPT 

Docket. The OPPT Docket is located in 

the EPA Docket Center (EPA/DC) at Rm. 

3334, EPA West Bldg., 1301 

Constitution Ave., NW., Washington, 

DC. The EPA/DC Public Reading Room 

hours of operation are 8:30 a.m. to 4:30 

p.m., Monday through Friday, excluding 

Federal holidays. The telephone number 

of the EPA/DC Public Reading Room is 

(202) 566–1744, and the telephone 

number for the OPPT Docket is (202) 

566–0280. Docket visitors are required 

to show photographic identification, 

pass through a metal detector, and sign 

the EPA visitor log. All visitor bags are 

processed through an X-ray machine 

and subject to search. Visitors will be 

provided an EPA/DC badge that must be 

visible at all times in the building and 

returned upon departure. 

2. Electronic access. You may access 

this Federal Register document 

electronically through the EPA Internet 

under the Federal Register listings at 

http://www.epa.gov/fedrgstr. You may 

access information about the EDSP at 

http://www.epa.gov/scipoly/oscpendo/ 

index.htm. 

II. Introduction 

A. What Action is the Agency Taking? 

EPA is announcing the final list of the 

first group of chemicals that will be 

screened in the Agency’s Endocrine 

Disruptor Screening Program (EDSP) 

based on the approach described in the 

Federal Register notice of September 

27, 2005 (70 FR 56449) (FRL–7716–9), 

and consideration of comments received 

on the draft list of chemicals published 

in the Federal Register notice of June 

18, 2007 (72 FR 33486) (FRL–8129–3). 

The approach focused on human 

exposure-related factors rather than a 

combination of exposure- and effectsrelated factors. The approach did not 

include a literature search for or 

consideration of any data on potential 

endocrine effects. Because EPA 

developed this list of chemicals based 

upon exposure potential, it should not 

be construed as a list of known or likely 

endocrine disruptors, and it would be 

inappropriate to do so. Nothing in the 

approach for generating the initial list 

provides a basis to infer that by simply 

being on this list these chemicals are 

suspected to interfere with the 

endocrine systems of humans or other 

species. 

The first group of chemicals to be 

tested consists of chemicals that section 

408(p) of the Federal Food, Drug, and 

Cosmetic Act (FFDCA) requires be 

screened, i.e., pesticide active 

ingredients and chemicals used as 

pesticide inert ingredients (also known 

as other ingredients) that are also HPV 

chemicals. EPA anticipates that it may, 

in the future, modify its approach to 

selecting chemicals for screening. 

Information and factors that EPA may 

consider in selecting chemicals could 

include: Public input; the results of 

testing chemicals on the initial list; 

management considerations to increase 

the integration of screening with other 

regulatory activities within the Agency; 

implementation considerations flowing 

from a decision to extend screening to 

additional categories of chemicals (e.g., 

non-pesticide chemical substances); and 

the availability of new priority setting 

tools (e.g., High Throughput Prescreening or Quantitative Structure 

Activity Relationships models). More 

information on EPA’s priority setting 

approach is available at http:// 

www.epa.gov/scipoly/oscpendo/pubs/ 

prioritysetting. 

EPA’s general focus in the approach 

for the initial list was on pesticide 

active ingredients and inert ingredients 

with relatively greater potential for 

human exposure. The emphasis on 

human exposure does not necessarily 

mean that the list will not contain 

substances that may not also have 

potentially high levels of environmental 

exposure to ecological receptors. This 

Federal Register document identifies 

the chemicals that were removed from 

the draft list and presents the final list 

of the first group of chemicals that will 

be screened in the Agency’s EDSP in 

alphabetical order. This document does 

not describe other aspects of the EDSP 

such as the administrative procedures 

EPA will use to require testing, the 

validated tests and battery that will be 

included in the EDSP, or the timeframe 

for requiring the testing or receiving the 

data. These topics will be addressed in 

separate notices published in the 

Federal Register, with the 

administrative procedures described in 

a separate notice published in today’s 

Federal Register. 

B. What is the Agency’s Authority for 

Taking this Action? 

Section 408(p) of FFDCA requires 

EPA to ‘‘develop a screening program, 

using appropriate validated test systems 

and other scientifically relevant 

information, to determine whether 

certain substances may have an effect in 

humans that is similar to an effect 

produced by a naturally occurring 

estrogen, or such other endocrine effect 

as [EPA] may designate.’’ (21 U.S.C. 

346a(p)). The statute generally requires 

EPA to ‘‘provide for the testing of all 

pesticide chemicals.’’ (21 U.S.C. 

346a(p)(3)). However, EPA is authorized 

to exempt a chemical, by order upon a 

determination that ‘‘the substance is 

anticipated not to produce any effect in 

humans similar to an effect produced by 

a naturally occurring estrogen.’’ (21 

U.S.C. 346a(p)(4)). ‘‘Pesticide chemical’’ 

is defined as ‘‘any substance that is a 

pesticide within the meaning of the 

Federal Insecticide, Fungicide, and 

Rodenticide Act (FIFRA), including all 

active and inert ingredients of such 

pesticide.’’ (21 U.S.C. 321(q)(1)). 

III. Background 

EPA developed its EDSP in response 

to the Congressional mandate in section 

408(p) of FFDCA to ‘‘develop a 

screening program. . .to determine 

whether certain substances may have an 

effect in humans that is similar to an 

effect produced by a naturally occurring 

estrogen, or such other endocrine effects 

as [EPA] may designate’’ (21 U.S.C. 

346a(p)). When carrying out the 

program, the statute requires EPA to 

‘‘provide for the testing of all pesticide 

chemicals.’’ The statute also provides 

EPA with discretionary authority to 

‘‘provide for the testing of any other 

substance that may have an effect that 

is cumulative to an effect of a pesticide 

chemical if the Administrator 

determines that a substantial population 

may be exposed to such a substance.’’ In 

addition, section 1457 of the Safe 

Drinking Water Act (SDWA) provides 

EPA with discretionary authority to 

provide for testing, under the FFDCA 

section 408(p) screening program, ‘‘of 

any other substances that may be found 

in sources of drinking water if the 

Administrator determines that a 

substantial population may be exposed 

to such substance.’’ 

EPA initially set forth the EDSP in the 

August 11, 1998 Federal Register notice 

(63 FR 42852) (FRL–6021–3), and 

solicited public comment on the 

program in the December 28, 1998 

Federal Register notice (63 FR 71542) 

(FRL–6052–9). The program set forth in 

these notices was based on the 

recommendations of the Endocrine 

Disruptor Screening and Testing 

Advisory Committee (EDSTAC), which 

was chartered under the Federal 

Advisory Committee Act (FACA), 5 

U.S.C. App.2, section 9(c). The EDSTAC 

was comprised of members representing 

the commercial chemical and pesticides 

industries, Federal and State agencies, 


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worker protection and labor 

organizations, environmental and public 

health groups, and research scientists. 

EDSTAC recommended that EPA’s 

program address both potential human 

and ecological effects; examine effects 

on estrogen, androgen, and thyroid 

hormone-related processes; and include 

non-pesticide chemicals, contaminants, 

and mixtures in addition to pesticides 

(Ref. 1). Based on these 

recommendations, EPA developed a 

two-tiered approach, referred to as the 

EDSP. The purpose of Tier 1 screening 

(referred to as ‘‘screening’’) is to identify 

substances that have the potential to 

interact with the estrogen, androgen, or 

thyroid hormone systems using a battery 

of assays. The purpose of Tier 2 testing 

(referred to as ‘‘testing’’) is to identify 

and establish a dose-response 

relationship for any adverse effects that 

might result from the interactions 

identified through the Tier 1 assays. 

EDSTAC also recommended that EPA 

establish a priority-setting approach for 

choosing chemicals to undergo Tier 1 

screening. EPA described this approach 

in the Federal Register of September 

2005. More information on EPA’s 

priority setting approach for the EDSP is 

available at http://www.epa.gov/scipoly/ 

oscpendo/prioritysetting. 

EPA currently is implementing its 

EDSP in three major parts that are being 

developed in parallel. 

1. Assay validation. Under FFDCA 

section 408(p), EPA is required to use 

‘‘appropriate validated test systems and 

other scientifically relevant 

information’’ to determine whether 

substances may have estrogenic effects 

in humans or other endocrine effects as 

the Administrator may designate. 

Validation is defined as the process by 

which the reliability and relevance of 

test methods are evaluated for the 

purpose of supporting a specific use. 

The proposed EDSP Tier 1 screening 

battery of assays was presented to the 

FIFRA Scientific Advisory Panel (SAP) 

during a public meeting on March 25– 

27, 2008. The FIFRA SAP report 

covering the meeting is available at 

http://www.epa.gov/scipoly/sap/ 

meetings/2008/march/minutes2008-03- 

25.pdf. The final Tier 1 battery will be 

announced in a separate Federal 

Register document that the Agency 

anticipates issuing in spring 2009. EPA 

is also in the process of developing and 

validating Tier 2 tests. The status of 

each assay can be viewed on the EDSP 

website in the Assay Status table: http:// 

www.epa.gov/scipoly/oscpendo/pubs/ 

assayvalidation/status.htm. 

2. Priority setting. EPA described its 

priority setting approach for the first 

group of pesticide chemicals to be tested 

in the Federal Register of September 

2005, and proposed the draft list of 

initial chemicals for review and public 

comment in the Federal Register notice 

of June 18, 2007 (72 FR 33486) (FRL– 

8129–3). The Agency is responding to 

the public comments in a separate 

document (Ref. 2) posted in the docket 

that was established for this action 

(EPA–HQ–OPPT–2004–0109). This 

document today announces the final list 

of initial chemicals to undergo Tier 1 

screening. More information on EPA’s 

priority setting approach for the EDSP is 

available at http:/ /www.epa.gov/ 

scipoly/oscpendo/prioritysetting. 

3. Procedures. EPA intends to 

commence Tier 1 screening of the first 

group of pesticide chemicals by issuing 

test orders under FFDCA section 408(p) 

to chemical companies identified as the 

manufacturer or processor of the 

identified chemicals and/or the 

pesticide registrants. EPA published 

draft policies and procedures in the 

Federal Register notice of December 13, 

2007 (72 FR 70842) (FRL–8340–3), that 

describes the procedures that EPA will 

use to issue orders, the procedures that 

Order recipients would use to respond 

to the order, how data protection and 

compensation will be addressed in the 

test orders, and other related procedures 

or policies. In addition, EPA developed 

a draft template for the test order and a 

draft information collection request 

(ICR) to obtain the necessary clearances 

under the Paperwork Reduction Act 

(PRA). Elsewhere is this issue of the 

Federal Register, the Agency is 

publishing the final policies and 

procedures, and the announcement of 

the ICR’s submission to OMB. 

Based on the current timing for each 

of the three major parts of the EDSP, the 

Agency intends to initiate the EDSP Tier 

1 screening for the first group of 

pesticide chemicals by issuing test 

orders in 2009. This document deals 

only with the final list of chemicals 

initially selected to go through 

screening in the Tier 1 assays. 

IV. Development of the Initial List of 

Chemicals 

The development of the initial list of 

chemicals is described in detail in the 

September 2005 and the June 2007 

Federal Register notices. 

Comments on the Final List 

EPA received comments on the 

proposed initial list including 

suggestions for additional chemicals, 

questions regarding the need for Tier 1 

screening data, the future chemical 

selection approach, and claims for 

removal of chemicals from the list. One 

of the main concerns was whether and 

how EPA would consider existing data 

in determining what screening assays 

were necessary. Although EPA does not 

currently intend to tailor test orders 

based on existing information, as 

articulated in the Reponse to Comments 

on the Draft List of Initial Pesticide 

Active Ingredients and Pesticide Inert 

Ingredients to be Screened under the 

Federal Food, Drug, and Cosmetic Act 

(Ref. 2), EPA will provide a mechanism 

whereby test order recipients and the 

public can provide information on 

specific chemicals for which test orders 

are issued. A test order recipient can 

elect to cite or submit existing data the 

recipient believes can be used to satisfy 

part or all of the Tier 1 Order and/or 

otherwise inform the determination as 

to whether the substance may have an 

effect that is similar to an effect 

produced by a substance that interacts 

with the estrogen, androgen and/or 

thyroid hormonal systems. In order for 

EPA to review the submission in a 

timely manner, in submitting or citing 

existing data, the order recipient should 

consider providing an explanation of 

the relevance of the data to the order, 

including, where appropriate, a cogent 

and complete rationale for why it 

believes the information is sufficient to 

satisfy part or all of the Tier 1 Order. 

The recipient’s response to test orders 

for Tier 1 assays will be evaluated by 

EPA to determine whether the cited data 

can be used to satisfy the order and/or 

otherwise inform the Tier 1 

determination. This will require a caseby-case determination of whether the 

information submitted is of high quality 

and achieves the objective of Tier 1. 

This approach is consistent with 

ensuring effective and efficient use of 

societal and government resources in 

generating and reviewing data, as well 

as minimizing the use of animals in 

regulatory testing, to achieve the 

information base needed to support a 

specified objective. 

These comments have been addressed 

in a document, entitled Reponse to 

Comments on the Draft List of Initial 

Pesticide Active Ingredients and 

Pesticide Inert Ingredients to be 

Screened under the Federal Food, Drug, 

and Cosmetic Act (Ref. 2), available in 

the docket for this action under docket 

ID number EPA–HQ–OPPT–2004–0109. 

In addition, the Agency has written a 

paper entitled EPA’s Approach for 

Considering Other Scientifically 

Relevant Information (OSRI) under the 

Endocrine Disruptor Screening Program. 

This paper was developed by EPA to 

provide guidance to EPA staff and 

managers who will be reviewing the 

responses to Tier 1 Orders issued under 

the EDSP, and may also be of interest to 


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parties considering whether to submit 

other scientically relevant information 

to EPA. This paper provides general 

guidance and is not binding on either 

EPA or any outside parties. Anyone may 

provide other scientifically relevant 

information, and the Agency will assess 

the information for appropriateness on a 

case-by-case basis, responding to the 

submitter in writing, and making EPA’s 

determination publicly available. A 

copy of this paper has been placed in 

the Docket for the Policies and 

Procedures for the Initial EDSP 

Screening (Docket ID number EPA–HQ– 

OPPT–2007–1080). 

V. The Final List of Initial Pesticide 

Active Ingredients and Pesticide Inert 

Ingredients (also known as other 

ingredients) to be Considered for 

Screening under the FFDCA 

A. Chemicals Removed from the Draft 

List of Proposed Chemicals for Initial 

Screening 

No HPV pesticide inert ingredients 

were removed. Six pesticide active 

chemicals were removed from the draft 

list of proposed chemicals for initial 

screening that resulted in this final list. 

Two of the chemicals, azinphos-methyl 

and fenvalerate, were removed from the 

list because all uses of these pesticides 

have ended or will end before Tier 2 

data could be generated in 2012. The 

remaining four chemicals were removed 

based on a reassessment of their uses 

that confirmed that they would only be 

expected to be present in two, instead 

of three, exposure pathways (i.e., the 

criterion for selecting chemicals for the 

initial list was the presence of the 

chemical in at least three of the four 

exposure pathways where the food and 

occupational exposure pathways were 

represented). Specifically, aldicarb, 

allethrin, dichlorvos, and methiocarb, 

were removed from the initial list 

because changes in their use and 

application methods has eliminated the 

potential for exposure in one or more 

pathways. As described in the 

September 2005 and June 2007 Federal 

Register notices, higher occupational 

exposure was based on the potential for 

agricultural workers to come into 

contact with a pesticide residue after its 

application (e.g., a worker pruning fruit 

trees or harvesting a crop). For 

occupational exposure, EPA relied on 

databases that assessed the exposure 

potential for workers who might enter a 

field or orchard after treatment with 

pesticides. In two cases (aldicarb and 

methiocarb), EPA regulation has either 

eliminated specific uses or changed the 

method of application which has 

eliminated or reduced the potential for 

post-application exposure below the 

threshold described in the previous 

Federal Register notices (September 

2005 and June 2007) where EPA 

identified 14 work activities/crop 

categories (e.g., tree fruit crops) having 

the highest transfer coefficients. In the 

case of aldicarb, the pesticide can only 

be applied by soil incorporation while 

in the case of methiocarb, the remaining 

agricultural uses are granular 

applications in nurseries and 

greenhouses. There are currently no 

registered uses of dichlorvos that will 

result in occupational exposure 

pathways associated with the selected 

14 work activities/crop categories 

having the highest transfer coefficients. 

Finally, current registrations for 

allethrin and methiocarb no longer 

include uses on food crops. Since these 

four chemicals no longer meet the 

listing criteria, they are being deleted 

from the initial list of chemicals to be 

screened. However, it should be noted 

that all pesticidal chemicals will 

eventually be screened for their 

potential to interact with the endocrine 

system as required by the statute. (21 

U.S.C. 346a(p)(3)). 

Table 1 presents an alphabetized list 

of the six pesticide active ingredients 

that were removed from the original list 

of 73 chemicals recommended for Tier 

1 screening in the EDSP and provides 

the rationale for their removal from the 

list. 

TABLE 1.—CHEMICALS REMOVED FROM THE INITIAL LIST OF CHEMICALS FOR TIER 1 SCREENING IN THE EDSP (THESE

ARE ALL PESTICIDE ACTIVE INGREDIENTS) 

Chemical Name CAS Number Reason for Removal from Testing List 

Aldicarb 116063 The initial analysis using the exposure based criteria for chemical selection found aldicarb in three exposure pathways: Food, water, and 

occupational. Due to changes in the use pattern, aldicarb is only 

present in two exposure pathways (food and water) and will not be 

tested at this time. 

Allethrin 584792 The initial analysis using the exposure based criteria for chemical selection found allethrin in three exposure pathways: Food, residential, 

and occupational. There are currently no registered food uses for this 

chemical. Allethrin is only present in two exposure pathways (occupational and residential) and will not be tested at this time. 

Azinphos–Methyl 86500 The initial analysis using the exposure based criteria for chemical selection found azinphos-methyl in three exposure pathways: Food, 

water, and occupational. All uses of azinphos-methyl will cease by 

2012. For this reason azinphos-methyl will not be tested. 

Dichlorvos 62737 The initial analysis using the exposure based criteria for chemical selection found dichlorvos in three exposure pathways: Food, residential, and occupational. There are currently no registered uses of 

dichlorvos that will result in occupational exposure pathways associated with the selected 14 work activities/crop categories having the 

highest transfer coefficients. Dichlorvos is only present in two exposure pathways (food and residential) and will not be tested at this 

time. 


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TABLE 1.—CHEMICALS REMOVED FROM THE INITIAL LIST OF CHEMICALS FOR TIER 1 SCREENING IN THE EDSP (THESE

ARE ALL PESTICIDE ACTIVE INGREDIENTS)—Continued 

Chemical Name CAS Number Reason for Removal from Testing List 

Fenvalerate 51630581 The initial analysis using the exposure based criteria for chemical selection found fenvalerate in three exposure pathways: Food, residential, and occupational. There are currently no registered food uses for 

this chemical. In addition, the registrant voluntarily ceased production 

of fenvalerate. As of the August 2007 deadline, no end use registrants have indicated a source of the technical grade active ingredient. The few remaining products under existing stocks are primarily 

for residential use with a few labeled for commercial use in food handling establishments. For this reason, fenvalerate will not be tested. 

Methiocarb 2032657 The initial analysis using the exposure based criteria for chemical selection found methiocarb in four exposure pathways: Food, water, 

residential, and occupational. Due to changes in the use pattern, 

methiocarb is only present in two exposure pathways (water and residential) and will not be tested at this time. 

B. The Final List of Pesticide Chemicals 

for Initial Screening 

Table 2 presents an alphabetized list 

of the 67 pesticide active ingredients 

and HPV/pesticide inert chemicals for 

screening in the EDSP. Because this list 

of chemicals was selected on the basis 

of exposure potential only, it should 

neither be construed as a list of known 

or likely endocrine disruptors nor 

characterized as such. 

TABLE 2.—FINAL LIST OF CHEMICALS FOR TIER 1 SCREENING IN THE EDSP 

Chemical Name CAS Number Pesticide Active 

Ingredient HPV/Inert 

2,4-D 94757 x 

4,7–Methano–1H–isoindole–1,3(2H)–dione, 2–(2–ethylhexyl)–3a,4,7,7a– 

tetrahydro– 113484 x 

Abamectin 71751412 x 

Acephate 30560191 x 

Acetone 67641 x 

Atrazine 1912249 x 

Benfluralin 1861401 x 

Bifenthrin 82657043 x 

Butyl benzyl phthalate 85687 x 

Captan 133062 x 

Carbamothioic acid, dipropyl–, S–ethyl ester 759944 x 

Carbaryl 63252 x 

Carbofuran 1563662 x 

Chlorothalonil 1897456 x 

Chlorpyrifos 2921882 x 

Cyfluthrin 68359375 x 

Cypermethrin 52315078 x 

DCPA (or chlorthal–dimethyl) 1861321 x 

Diazinon 333415 x 

Dibutyl phthalate 84742 x 

Dichlobenil 1194656 x 


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TABLE 2.—FINAL LIST OF CHEMICALS FOR TIER 1 SCREENING IN THE EDSP—Continued 

Chemical Name CAS Number Pesticide Active 

Ingredient HPV/Inert 

Dicofol 115322 x 

Diethyl phthalate 84662 x 

Dimethoate 60515 x 

Dimethyl phthalate 131113 x 

Di–sec–octyl phthalate 117817 x 

Disulfoton 298044 x 

Endosulfan 115297 x 

Esfenvalerate 66230044 x 

Ethoprop 13194484 x 

Fenbutatin oxide 13356086 x 

Flutolanil 66332965 x 

Folpet 133073 x 

Gardona (cis–isomer) 22248799 x 

Glyphosate 1071836 x 

Imidacloprid 138261413 x 

Iprodione 36734197 x 

Isophorone 78591 x 

Linuron 330552 x 

Malathion 121755 x 

Metalaxyl 57837191 x 

Methamidophos 10265926 x 

Methidathion 950378 x 

Methomyl 16752775 x 

Methyl ethyl ketone 78933 x 

Methyl parathion 298000 x 

Metolachlor 51218452 x 

Metribuzin 21087649 x 

Myclobutanil 88671890 x 

Norflurazon 27314132 x 

o–Phenylphenol 90437 x 

Oxamyl 23135220 x 

Permethrin 52645531 x 

Phosmet 732116 x 

Piperonyl butoxide 51036 x 

Propachlor 1918167 x 

Propargite 2312358 x 


rwilkins on PROD1PC63 with PROPOSALS
Federal Register / Vol. 74, No. 71 / Wednesday, April 15, 2009 / Notices 17585 

TABLE 2.—FINAL LIST OF CHEMICALS FOR TIER 1 SCREENING IN THE EDSP—Continued 

Chemical Name CAS Number Pesticide Active 

Ingredient HPV/Inert 

Propiconazole 60207901 x 

Propyzamide 23950585 x 

Pyridine, 2-(1-methyl-2-(4-phenoxyphenoxy)ethoxy)- 95737681 x 

Quintozene 82688 x 

Resmethrin 10453868 x 

Simazine 122349 x 

Tebuconazole 107534963 x 

Toluene 108883 x 

Triadimefon 43121433 x 

Trifluralin 1582098 x 

VI. References 

These references are available in the 

docket as identified under ADDRESSES, 

under Docket ID No. EPA–HQ–OPPT– 

2004–0109, which is the docket for the 

chemicals selected for the initial round 

of screening under the EDSP. In 

addition, the first document referenced 

is available in Docket ID No. EPA–HQ– 

OPPT–2002–0066, which is the docket 

used for the proposed chemical 

selection approach described in the 

Federal Register notice of December 30, 

2002 (67 FR 79611) (FRL–7286–6). 

1. U.S. EPA. Endocrine Disruptor 

Screening and Testing Advisory 

Committee Final Report. August 1998. 

Available at: http:// www.epa.gov/ 

scipoly/oscpendo/edspoverview/ 

finalrpt.htm. (Document ID No. EPA– 

HQ–OPPT–2002–0066–0003). 

2. U.S. EPA. ‘‘Reponse to Comments 

on the Draft List of Initial Pesticide 

Active Ingredients and Pesticide Inert 

Ingredients to be Screened under the 

Federal Food, Drug, and Cosmetic Act.’’ 

August 2008. Available at: http:// 

www.epa.gov/scipoly/oscpendo/pubs/ 

prioritysetting/. (Docket ID No. EPA– 

HQ–OPPT–2004–0109). 

List of Subjects 

Environmental protection, Chemicals, 

Endocrine disruptors, Pesticides. 

Dated: April 3, 2009. 

James Jones, 

Acting Assistant Administrator, Office of 

Prevention, Pesticides and Toxic Substances. 

[FR Doc. E9–8709 Filed 4–14–09; 8:45 am] 

BILLING CODE 6560–50–S 


rwilkins on PROD1PC63 with PROPOSALS