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Prometon Focus Meeting Summary

November 7, 2012 

1:00 – 2:00 pm

Attendees

MANA: Kristen Knox and (via conference line) Elliot Gordon

Control Solutions, Inc.(via conference line): Anne Turnbough

Environmental Protection Agency (EPA or Agency): Kaitlin Keller (PRD), Tracy Perry

(PRD), William Irwin (HED), Robin Sternberg (EFED), Steve Wente (EFED), Sujatha Sankula 

(EFED), Cynthia Doucoure (BEAD), John Faulkner (BEAD)

Objective

The purpose of the meeting was for members of the EPA’s Pesticide Re-evaluation Division 

(PRD), Environmental Fate and Effects Division (EFED), Biological and Economic Analysis 

Division (BEAD), and Health Effects Division (HED) to meet with Mahkteshim Agan of North 

America (MANA), the technical registrant for prometon, for the following reasons: 1) discuss 

usage information needed for the registration review ecological risk assessments, and 2) discuss 

anticipated ecotoxicity and environmental fate data requirements and information that could be 

submitted to fulfill these data gaps. 

Discussion

Use/Usage Information

CSI provided usage information in terms of amounts used in pounds per year, noting that this 

information can be broken down by product and will be submitted to the Agency via email with 

a complete summary of labels and use sites. MANA confirmed that all residential use products 

have been cancelled, as required by the Reregistration Eligibility Decision (RED). EPA has 

already received a FIFRA 6(f) request to cancel all residential uses of prometon on October 3, 

2012, which will be published with a 30-day comment period in the Federal Register in FY 2013 

Q1. EPA requested additional information on typical rates for each use scenario and the size of a 

typical spot treatment along various use sites, such as highway medians, fencerows, and airports. 

EPA noted that this information could help reduce conservatisms in the ecological risk 

assessments. 

Environmental Fate and Effects Information

EPA requested additional information on the degradates of prometon, specifically how long they

take to break down and any toxicity effects in the environment and/or any laboratory studies 

using rats. MANA committed to reviewing their database and providing any information within 

three weeks of the meeting date.

EPA also presented a list of anticipated data gaps and explained that some conservative methods, 

such as the acute-to-chronic ratio, could be used to account for the lack of several of the data 

gaps. MANA stated that European Union (EU) data is not available for this chemical and all 
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studies were already submitted before the RED was completed. EPA suggested reviewing open 

literature and their database for information on other triazine herbicides, such as atrazine and 

simazine, for information which may be useful. EPA agreed to review and consider any 

proposals or waiver requests based on a rationale of low toxicity and/or bridging data used for 

other triazine class herbicides. EPA requested any water monitoring data available. MANA was 

not aware of this information but agreed to submit any water monitoring data that they may find.

Follow-up

 EPA will inform MANA when the 6(f) voluntary cancellation request for all prometon 

residential uses publishes in the Federal Register.

 MANA and CSI will submit use/usage and market share information, as well as typical 

use rates and size of typical spot treatments.

 MANA will review their scientific database and open literature sources for information 

that could fulfill current data gaps and respond to EPA with this information within three 

weeks.