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  Exhibit 4.22    
    


 
    SIXTH SUPPLEMENTAL INDENTURE    
    


        This SIXTH SUPPLEMENTAL INDENTURE (this "Supplemental Indenture"), dated as of December 27, 2011, is among MarkWest Energy
Partners, L.P., a Delaware limited partnership (the "Partnership"), MarkWest Energy Finance Corporation, a Delaware corporation ("MarkWest Finance" and, together with the Partnership, the
"Issuers"), each of the other parties identified on the signature page hereto (the "Subsidiary Guarantors") and Wells Fargo Bank, National Association, a national banking association, as Trustee. 


 
 

  RECITALS    
    


        WHEREAS, the Issuers, the Subsidiary Guarantors and the Trustee are parties to (i) an Indenture, dated as of November 2,
2010 (as amended and supplemented by the first supplemental indenture, the third supplemental indenture and the fourth supplemental indenture thereto, the "2020 Notes Indenture"), pursuant to which
the Issuers have issued $500,000,000 in principal amount of 63/4% Senior Notes due 2020 (the "2020 Notes"), (ii) an Indenture, dated as of November 2, 2010 (as amended and
supplemented by the second supplemental indenture, the third supplemental indenture and the fourth supplemental indenture thereto, the "2021 Notes Indenture"), pursuant to which the Issuers have
issued $500,000,000 in principal amount of 6.5% Senior Notes due 2021 (the "2021 Notes") and (iii) an Indenture, dated as of November 2, 2010 (as amended and
supplemented by the fifth supplemental indenture thereto, the "2022 Notes Indenture" and together with the 2020 Notes Indenture and the 2021 Notes Indenture, the "Indentures"), pursuant to which the
Issuers have issued $700,000,000 in principal amount of 6.25% Senior Notes due 2022 (the "2022 Notes" and together with the 2020 Notes and the 2021 Notes, the "Notes"); 


        WHEREAS,
Section 10.01(a) of each of the Indentures provides that the Issuers, the Subsidiary Guarantors and the Trustee may amend or supplement the Indentures in order to cure
any ambiguity, defect or inconsistency, without the consent of the Holders of the Notes; 


        WHEREAS,
clause (c) of the definition of "Non-Recourse Debt" in Section 2.01 of each Indenture refers to an exception contemplated by clause (o) of the
definition of "Permitted Liens" allowing recourse by lenders in certain circumstances to the stock or assets of the Partnership or any of its Restricted Subsidiaries; 


        WHEREAS,
such clause (o) contemplates no such exception and relates solely to certain Liens incurred in the ordinary course of business of the Partnership or any of its Restricted
Subsidiaries, while the preceding clause (n) relates to Liens on and pledges of the Equity Interests of any Unrestricted Subsidiary or any Joint Venture owned by the Partnership or any of its
Restricted Subsidiaries to the extent securing Non-Recourse Debt or other Indebtedness of such Unrestricted Subsidiary or Joint Venture; 


        WHEREAS,
such clause (o) of the definition of "Permitted Liens" is manifestly inconsistent with the reference to it in clause (c) of the definition of
"Non-Recourse Debt," such reference being manifestly to, and consistent only with, the preceding clause (n) of the definition of "Permitted Liens"; and 


        WHEREAS,
all acts and things prescribed by the Indentures, by law and by the Certificate of Incorporation and the Bylaws (or comparable constituent documents) of the Issuers, of the
Subsidiary Guarantors and of the Trustee necessary to make this Supplemental Indenture a valid instrument legally binding on the Issuers, the Subsidiary Guarantors and the Trustee, in accordance with
its terms, have been duly done and performed; 







 

        NOW,
THEREFORE, to comply with the provisions of the Indentures and in consideration of the above premises, the Issuers, the Subsidiary Guarantors and the Trustee covenant and agree for
the equal and proportionate benefit of the respective Holders of the Notes as follows: 


 
 

  ARTICLE 1    
    


        This Supplemental Indenture is supplemental to the Indentures and does and shall be deemed to form a part of, and shall be
construed in connection with and as part of, the Indentures for any and all purposes. 


        This
Supplemental Indenture shall become effective immediately upon its execution and delivery by each of the Issuers, the Subsidiary Guarantors and the Trustee. 


 
 

  ARTICLE II    
    


        Clause (c) in the definition of "Non-Recourse Debt" in Section 2.01 of each Indenture is hereby amended by
substituting the words "clause (n)" for the words "clause (o)" in the final line thereof. 


 
 

  ARTICLE III    
    


        Except as specifically modified herein, the Indentures and the Notes are in all respects ratified and confirmed
(mutatis mutandis) and shall remain in full force and effect in accordance with their terms with all capitalized terms used herein without definition
having the same respective meanings ascribed to them as in the Indentures. 


        The
Trustee accepts the amendments of the Indentures effected by this Supplemental Indenture and agrees to execute the trust created by the Indentures as hereby amended, but on the terms
and conditions set forth in the Indentures, including the terms and provisions defining and limiting the liabilities and responsibilities of the Trustee, which terms and provisions shall in like
manner define and limit its liabilities and responsibilities in the performance of the trust created by the Indentures as
hereby amended, and without limiting the generality of the foregoing, the Trustee shall not be responsible in any manner whatsoever for or with respect to any of the recitals or statements contained
herein, all of which recitals or statements are made solely by the Issuers and the Subsidiary Guarantors, and the Trustee makes no representation with respect to any such matters. Additionally, the
Trustee makes no representations as to the validity or sufficiency of this Supplemental Indenture. 


        THIS
SUPPLEMENTAL INDENTURE SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK. 



        The
parties may sign any number of copies of this Supplemental Indenture. Each signed copy shall be an original, but all of such executed copies together shall represent the same
agreement. 


        [NEXT
PAGE IS SIGNATURE PAGE] 

   


   


        Sixth Supplemental Indenture


2







 

        IN
WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly executed, all as of the date first written above. 

 






					
	 
	 	MARKWEST ENERGY FINANCE CORPORATION
	

 
	
 	
  By:	
 	
/s/ Nancy Buese







 
	 
	 	Name:	 	Nancy Buese
	 
	 	Title:	 	Senior Vice President and Chief Financial Officer
	 
	 	  MARKWEST ENERGY PARTNERS, L.P.

	 
	 	 By:
	 	 MarkWest Energy GP, L.L.C.,

its General Partner

	

 
	
 	
 By:	
 	
/s/ Nancy Buese







 
	 
	 	Name:	 	Nancy Buese
	 
	 	Title:	 	Senior Vice President and Chief Financial Officer
	 
	 	   MARKWEST HYDROCARBON, INC.

	

 
	
 	
 By:	
 	
/s/ Nancy Buese







 
	 
	 	Name:	 	Nancy Buese
	 
	 	Title:	 	Senior Vice President and Chief Financial Officer
	 
	 	   MARKWEST ENERGY GP, L.L.C.

	

 
	
 	
 By:	
 	
/s/ Nancy Buese







 
	 
	 	Name:	 	Nancy Buese
	 
	 	Title:	 	Senior Vice President and Chief Financial Officer




 


   

   


         Signature Page to Sixth Supplemental Indenture


3







 

 


 






					
	 
	 	 MASON PIPELINE LIMITED LIABILITY COMPANY
	 
	 	 By:
	 	 MarkWest Hydrocarbon, Inc.,

its Sole Member

	

 
	
 	
 By:	
 	
/s/ Nancy Buese







 
	 
	 	Name:	 	Nancy Buese
	 
	 	Title:	 	Senior Vice President and Chief Financial Officer
	 
	 	   MARKWEST ENERGY OPERATING COMPANY, L.L.C.

	 
	 	 By:
	 	 MarkWest Energy Partners, L.P.,

its Managing Member

	 
	 	 By:
	 	 MarkWest Energy GP, L.L.C.,

its General Partner

	

 
	
 	
 By:	
 	
/s/ Nancy Buese







 
	 
	 	Name:	 	Nancy Buese
	 
	 	Title:	 	Senior Vice President and Chief Financial Officer




 


   

   


         Signature Page to Sixth Supplemental Indenture


4









 






































 






					
	 
	 	  MARKWEST BLACKHAWK, L.L.C.

	 
	 	  MARKWEST ENERGY APPALACHIA, L.L.C.

	 
	 	  MARKWEST ENERGY EAST TEXAS GAS COMPANY, L.L.C.

	 
	 	  MARKWEST GAS MARKETING, L.L.C.

	 
	 	  MARKWEST GAS SERVICES, L.L.C.

	 
	 	  MARKWEST JAVELINA COMPANY, L.L.C.

	 
	 	  MARKWEST JAVELINA PIPELINE COMPANY, L.L.C.

	 
	 	  MARKWEST LIBERTY GAS GATHERING, L.L.C.

	 
	 	  MARKWEST MARKETING, L.L.C.

	 
	 	  MARKWEST MOUNTAINEER PIPELINE COPMANY, L.L.C.

	 
	 	  MARKWEST NEW MEXICO, L.L.C.

	 
	 	  MARKWEST PINNACLE, L.L.C.

	 
	 	  MARKWEST PIPELINE COMPANY, L.L.C.

	 
	 	  MARKWEST PNG UTILITY, L.L.C.

	 
	 	  MARKWEST POWER TEX, L.L.C.

	 
	 	  MARKWEST TEXAS PNG UTILITY, L.L.C.

	 
	 	 By:
	 	 MarkWest Energy Operating Company, L.L.C.,

its Sole Member

	 
	 	 By:
	 	 MarkWest Energy Partners, L.P.,

its Managing Member

	 
	 	 By:
	 	 MarkWest Energy GP, L.L.C.,

its General Partner

	 
	 	 By:
	 	 /s/ Nancy Buese








 
	 
	 	 Name:
	 	Nancy Buese
	 
	 	 Title:
	 	Senior Vice President and Chief Financial Officer




 

 Signature Page to Sixth Supplemental Indenture


5







 
 






					
	

 	
 	
MARKWEST MICHIGAN PIPELINE COMPANY, L.L.C.

MARKWEST OKLAHOMA GAS COMPANY, L.L.C.
	

 	
 	
By:	
 	
MarkWest Energy Operating Company, L.L.C.,

its Managing Member
	

 	
 	
By:	
 	
MarkWest Energy Partners, L.P.,

its Managing Member
	

 	
 	
By:	
 	
MarkWest Energy GP, L.L.C.,

its General Partner
	

 	
 	
By:	
 	
/s/ Nancy Buese







 
	 	 	Name:	 	Nancy Buese
	 	 	Title:	 	Senior Vice President and Chief Financial Officer
	

 	
 	
MATREX, L.L.C.
	

 	
 	
By:	
 	
West Shore Processing Company L.L.C.,

its Sole Member and Manager
	

 	
 	
By:	
 	
MarkWest Energy Operating Company, L.L.C.,

its Sole Member and Manager
	

 	
 	
By:	
 	
MarkWest Energy Partners, L.P.,

its Managing Member
	

 	
 	
By:	
 	
MarkWest Energy GP, L.L.C.,

its General Partner
	

 	
 	
By:	
 	
/s/ Nancy Buese







 
	 	 	Name:	 	Nancy Buese
	 	 	Title:	 	Senior Vice President and Chief Financial Officer




 

 Signature Page to Sixth Supplemental Indenture


6









 






































 






					
	 	 	 MARKWEST MCALESTER, L.L.C.
	

 	
 	
By:	
 	
MarkWest Oklahoma Gas Company, L.L.C.,

its Sole Member
	

 	
 	
By:	
 	
MarkWest Energy Operating Company, L.L.C.,

its Managing Member
	

 	
 	
By:	
 	
MarkWest Energy Partners, L.P.,

its Managing Member
	

 	
 	
By:	
 	
MarkWest Energy GP, L.L.C.,

its General Partner
	

 	
 	
By:	
 	
/s/ Nancy Buese







 
	 	 	Name:	 	Nancy Buese
	 	 	Title:	 	Senior Vice President and Chief Financial Officer
	

 	
 	
MARKWEST RANGER PIPELINE COMPANY, L.L.C
	

 	
 	
By:	
 	
MarkWest Energy Appalachia, L.L.C.,

its Sole Member
	

 	
 	
By:	
 	
MarkWest Energy Operating Company, L.L.C.,

its Sole Member
	

 	
 	
By:	
 	
MarkWest Energy Partners, L.P.,

its Managing Member
	

 	
 	
By:	
 	
MarkWest Energy GP, L.L.C.,

its General Partner
	

 	
 	
By:	
 	
/s/ Nancy Buese







 
	 	 	Name:	 	Nancy Buese
	 	 	Title:	 	Senior Vice President and Chief Financial Officer




 

 Signature Page to Sixth Supplemental Indenture


7







 
 






					
	 	 	 WEST SHORE PROCESSING COMPANY L.L.C.
	

 	
 	
By:	
 	
MarkWest Energy Operating Company, L.L.C.,

its Sole Member and Manager
	

 	
 	
By:	
 	
MarkWest Energy Partners, L.P.,

its Managing Member
	

 	
 	
By:	
 	
MarkWest Energy GP, L.L.C.,

its General Partner
	

 	
 	
By:	
 	
/s/ Nancy Buese







 
	 	 	Name:	 	Nancy Buese
	 	 	Title:	 	Senior Vice President and Chief Financial Officer




 

 Signature Page to Sixth Supplemental Indenture


8







 
 






					
	 	 	 WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee
	

 	
 	
By:	
 	
/s/ Patrick Giordano







 
	 	 	Name:	 	Patrick Giordano
	 	 	Title:	 	Vice President




 

 Signature Page to Sixth Supplemental Indenture


9











QuickLinks



Exhibit 4.22


SIXTH SUPPLEMENTAL INDENTURE

RECITALS

ARTICLE 1

ARTICLE II

ARTICLE III