Page 1 of 12 **UNITED STA TES ENVIRONMENTA**  **L PROTECTION A GENCY**  WA SHINGTON, D.C. 20460

**OFFICE OF CHEMICAL SAFETY AND**  **POLLUTION PREVENTION MEMORANDUM**  **Date:** 31 - JUL - 201 3 **Subject: Prometryn**  **:** Acute and Chronic Dietary (Food and Drinking Water) Exposure and Risk Assessment to Support the Section 3 Registration Request For Use of Prometry n on Snap Beans and Dill . **PC Code:** 080805 **DP Barcode:** D408528 **Decision No.:** 467531 **Registration No :**  100 - 620 **Petition No.:** 2E8052 **Regulatory Action:** Amended Sec. 3 **Risk Assessment Type:** Dietary **Case No.:** 0467 **T XR No.:**  NA **CAS No.:** 7287 - 19 - 6 **MRID No.:** None **40 CFR:** §180. 222 **From:** Sarah J. L ev y , Chemist

Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P) **Through:** William Cutchin , Chemist

Id eliz Negron - Encarnacion , Ph.D. , Chemist Dietary Exposure Science Advisory Council (DESAC)/HED (7509P) and George F. Kramer, Ph.D., Branch Senior Scientist RAB1/HED (7509P) **To:** Kelly M. Lowe , Risk Assessor

RAB1/HED (7509P) and Barbara Madden, RM 05 Registration Division (RD; 7505P) **Executive Summary** Acute and chronic (food and drinking water) dietary - exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM - FCID) Version 3.16, which uses food consumption data from the U.S. Department of Agriculture’s National Health and Nutrition Examination Surve y, What We Eat in America, (NHANES/WWEIA) from 2003 through 2008. The anal ys es were performed toProm etryn Dietary Exposure and Risk Assessment DP# 408528

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Page 2 of 12 support Section 3 use request s on snap beans and dill . Itshould be noted that prometry n is alread y registered for use on dill; however, the current registration is limited to a regional registration. The Registrant has submitted additional data to expand the regional registration to a national registration. The proposed national use pattern is identical to the currentl y registered regional use pattern. These analy ses have been reviewed b y t wo peer reviewers of the DESAC, per the DESAC Standard Operating Procedure (SOP) 2012.1. Acute Dietary (Food and Drinking W ater) Exposure Results and Characterization The acute anal ys is assumed 100% crop treated (CT), tolerance - level residues for all foods, and DEEM 7.81 default processing factors. Dietary risk estimates were determined considering exposures from food plus drinking water using estimated drinking water concentrations (EDWCs) for surface water sources provided b y t he Environmental Fate and Effects Division (EFED). An acute EDWC value w as generated using the carrot use pattern as this use y ielded the highest acute EDWC value , 377.4 ppb . The acute assessm ent shows that the acute dietary risk estimate is not of concern to HED [i.e., <100% acute population - adjusted dose (aPAD)]. The resulting acute dietary (food + drinking water) risk estimates utilized 17 % of the aPAD for the females 13 - 49 y ears old population subgroup , the only acute population subgroup of concern for this assessment. Chronic Dietary (Food and Drinking W ater) Exposure Results and Characterization The chronic anal ys is assumed 100% crop treated (CT), tolerance - level residues for all food s, and DEEM 7.81 default processing factors. Dietary risk estimates were determined considering exposures from food plus drinking water using EDWCs for surface water sources provided b y EFED. A chronic EDWC va l ue w as generated using the carrot use patter n as this use y ielded the highest chronic EDWC value , 157.9 ppb . The assessment shows that the chronic dietary risk estimates are not of concern to HED [i.e., <100% chronic population - adjusted dose (cPAD)]. The resulting chronic dietary (food + drinking water) risk estimates utilized 8.6 % of the cPAD for the general U.S. population and 2 3 % of the cPAD for all infants (<1 y ear old) , the most highl y exposed population subgroup. Cancer A cancer dietary

assessment was not conducted because prometry n is classified as “Group E: Evidence of non - carcinogenicity for humans.” **I. Introduction** Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a max imum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population - adjusted dose (PAD). The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertaint y or safet y factors. For acute and non - cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more detail are ava ilable on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21 - JUN - 2000, web link:Prom etryn Dietary Exposure and Risk Assessment DP# 408528

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Page 3 of 12 http://www.epa.gov/fedrgstr/EPA - PEST/2000/July /Day - 12/6061.pdf; or see SOP 99.6 (20 - AUG 1999). The most recent d ietary

risk assessment for prometry n was conducted on 0 8 - AUG - 20 09 (Memo, W. Wassell ; D 367832 ). **II. Residue Information** Prometry n is a substituted thiomethy triazine herbicide (Group 5) registered in the U.S. for the control of weeds in a number of commodities. The Product and Residue Chemistry Chapters for the Prometry

n RED were issued 08 - DEC - 1994. Residues of Concern: HED previousl y determined that the residue of concern in plants consists of the parent, prometry

n per se , which is the currently regulated residue. HED concluded that if other major uses were registered in the future, additional metabolism studies would be required. The petitioner recentl y s ubmitted a metabolism study in rice which was reviewed as part of the following memorandum: S. L ev y, 13 - MAR - 2013; D 398563. Although the rice metabolism study was deemed adequate, it presents a qualitatively differe nt metabolic profile than the celery and cotton profiles (Memo, C. Swartz, 05 - DEC - 1994; D208880 and 09 - DEC - 1995; D207139, respectivel y). In the celery and cotton metabolism studies, parent was the major residue and in the rice metabolism study metabolite GS - 17794 was the major residue. Therefore, HED is still requesting a root crop metabolism study . **This deficiency remains outstanding.** Depending on results of the root crop metabolism study , additional field trial data could be required. The nature of the residue in livestock is adequately understood based on acceptable poultry and ruminant metabolism studies. The residue of concern (and that which should be regulated) in livestock is the parent, prometry n per se . As in plants, the metabolism of prometry n in livestock involves N

- dealky lation along with hy drol ys is and/or amino acid conjugation. The 1994 Residue Chemistry

Chapter concluded that residues of prometry n per se in meat and milk can be classified under Category 3 of 40 CFR §180.6(a). That is, there is no reasonable expectation of finite residues in meat and milk. No tolerances were required in the Residue Chapter; therefore, livestock feeding studies were not required. In the current petition, the only livestock feedstuff is cowpea, forage which may contribute up to 20% in dairy cow diets onl y. In the previously constructed dietary

burden, barley

forage was included in the dairy cattle diet. The established barley fora ge tolerance of 0.30 ppm is higher than the HED - recommended tolerance of 0.09 ppm associated with this petition; therefore, constructing a new dietary burden would result in a lower dietary burden. Pending submission of an additional plant metabolism stud y, HED tentativel y concludes that the Category 3 situation remains valid for this registration request. For drinking water, EFED included parent only , as was done in previous risk assessments . Modeling parent onl y is a high - end, conservative assumption . EFED stated that their entire drinking water assessment for prometry n will be updated concurrent with registration review. Established Tolerances: Permanent tolerances for residues of prometry n per se are currently established in/on a variety of crops (40 CFR §180. 222(a) ). There is also a tolerance with regional registration in/on dill as well as tolerances for indirect or inadvertent residues in/on hay , straw, and forage of barley , oat, ry e, triticale, and wheat.Prom etryn Dietary Exposure and Risk Assessment DP# 408528

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Page 4 of 12 Recommended Tolerances: Based on the residue chemistry data submitted with the current petition, HED recommended for establishment of the tolerances outlined below . Furthermore, in accordance with the most recent guidance concerning tolerance expressions, HED recommends that the tolerance expression for 40 CFR §180.222 be changed as indicated below. “(a) General. Tolerances are established for residues of the herbicide prometryn, including its metabolites and degradates, in or on the commodities in the table below . Compliance with the tolerance levels specified below is to be determined by measuring only prometr yn [2,4 - bis(isopropylamino) - 6 - methylthio - s - triazine] in or on the following raw agricultural commodities:”

Snap, bean, succulent ................................ ................................ ............. 0.05 ppm Dillweed, fresh leaves ................................ ................................ ............ 0.30 ppm Dill, dried leaves ................................ ................................ .................... 1.1 ppm and (d) Indirect or inadvertent residues. T olerances are established for indirect or inadvertent residues of the herbicide prom etryn, including its metabolites and degradates, in or on the commodities in the table below . Com pliance with the tolerance levels specified below is to be determined by m easuring only prometryn ([2,4 - bis(isopropylamino) - 6 - methylthio - s - triazine] in or on the following raw agricultural commodities:” Note that concurrent with the establishment of the HED - recommended tolerances for residues in/on dillweed, fresh leaves and di ll, dried leaves, the established tolerance of 0.3 ppm in/on dill with regional restriction should be removed in 40 CFR §180.222(c). Residue Data Used for Acute and Chronic Assessments: These anal ys es utilized established and HED - recommended toleranc e - level residues for all commodities and DEEM (ver. 7.81) default processing factors . **III. Percent Crop Treated**  Both the acute and chronic assessments utilized 100% CT for all commodities. **IV. Drinking Water Data**  Drinking water residues were incorporated directly into the acute and chronic dietary analy ses (“water, direct, all sources” and “water, indirect, all sources”) and were provided by EFED (Memo, M. Ruhman , 13 - MAR - 201 3 ; D 403977 ). The E DWCs were screening - level estimates generated with the Food Quality Protection Act (FQPA) Index Reservoir Screening Tool (FIRST) in surface water and with Screening Concentration in Ground Water (SCI - GROW) for ground water. The driver for the EDWCs, for s urface and ground water, was application to ( previousl y registered use) carrots ( three ground applications at 2 lbs a.i/A, 30 day s apart). **Table 1. Maximum Screening EDWCs of Prom**  **etryn for Current and Proposed Uses.**  **Drinking Water Source (m**  **odel) Use (Maxim**  **um Annual**  **Rate) Upper**  **- Bound Estimated Drinking** 

**Water Concentrations (ppb) Acute (peak**  **exposure) Chronic (annual** 

**mean exposure)** Surface Water (FIRST) Carrots (3 applications at 2 lb ai/A, 30 days apart) 377.4 157.9 Groundwater (SCI - GROW) Carrots (3 applications at 2 lb ai/A, 30 days apart) 23.4Prom etryn Dietary Exposure and Risk Assessment DP# 408528

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Page 5 of 12 Surface water EDWCs of 0. 3774 ppm and 0. 1579 ppm were used in the acute and chronic anal ys es, respectivel y, as these values were the highest and provided a more conservative approach. **IV. DEEM -**  **FCID Program and Consumption Information** Prometry n acute and chronic dietary exposure assessments were conducted using DEEM - FCID, Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEI A from 2003 through 2008. The data are ba sed on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. Howev er, for acute exposure assessment, consumption data are retained as individual consumption events. Based on anal ys is of the 2003 - 2008 WWEIA consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most ap propriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 y ear old), children 1 - 2, children 3 - 5, children 6 - 12, y outh 13 - 19, adults 20 - 49, females 13 - 49, and adults 50 - 99 ye ars old. For a chronic dietary exposure assessment, an estimate of the residue level in each food or food form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake e stimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day

and as a percent of the cPAD. This procedure is performed for each population subgroup. For an acute exposure assessment, individual one - day food consumption data are used on an individual - by - individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probab ilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eating relevant commodities/food forms) and a per - capita (i.e., those who reported eating the relevant commo dities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for anal ys es performed at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per c apita exposure and risk are specificall y identified and noted in the risk assessment. **V. Toxicological Information** Table 2 summarizes the toxicological doses and endpoints for prometry n concerning dietary exposure assessment. The endpoints have been reviewed by the risk assessment team and are considered appropriate for the current risk assessment.Prom etryn Dietary Exposure and Risk Assessment DP# 408528

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Page 6 of 12 **Table 2**  **. Summary of Toxicological Doses and Endpoints for Prom etryn**  **for Use in Dietary Hum an**  **- Health**  **Risk Assessments. Exposure Scenario**  **Point of Departure**  **Uncertainty/FQPA**

**Safety Factors RfD, PAD, LOC for** 

**Risk Assessment Study and Relevant**  **Toxicological Effects** Acute Dietary ( Females 13 - 49 years of age ) NOAEL = 12 mg/kg/day UF A = 10X

UF H = 10X UF FQPA = 1X aRfD = aPAD = 0.12

mg/kg/day **Developmental tox icity (ra**  **bbit )**  LOAEL = 72 mg/ kg based on increased incidence of resporptions, abortions, and post implantation loss leading to decreased number of viable litters and live fetuses. Chronic Dietary (All Populations) NOAEL = 3.75 mg/kg/day UF A = 10X

UF H = 10X UF FQPA = 1X cRfD = cPAD = 0.0 4

mg/kg/day **Chronic toxicity (dog; dietary)** LOAEL = 37.5 mg/kg/day based on degenerative hepatic changes, renal tubule degeneration, and bone marrow atrophy . Cancer (Oral, Dermal, Inhalation) Classification: “ Group E: Evidence of non - carcinogenicity for humans.” Abbreviations: UF = uncertainty factor, UF A = extrapolation from animal to human (interspecies), UF H = potential variation in sensitivity among members of the human population (intraspecies), UF FQPA = FQPA Safety Factor, NOAEL = no - observed adverse - effect level, LOAEL = lowest observed adverse - effect level, RfD = reference dose (a = acute, c = chronic), PAD = population - adjusted dose, LOC = level of concern. **VI. Results/Discussion** For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM - FCID anal ys es estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 3 are for the gener al U.S. population, all infants (<1 y ear old), children 1 - 2, children 3 - 5, children 6 - 12, y outh 13 - 19, females 13 - 49, adults 20 - 49, and adults 50 - 99 y ears. Results of Acute and Chronic Dietary Exposure Analy ses The resulting acute food plus drinking water risk estimates are not of concern to HED (<100% aPAD) at the 95 th percentile of the exposure. The resulting acute risk estimate is 1 7 % of the aPAD of the exposure distribution for females 13 to 49 y ears old , the onl y acute population subgroup of con cern for this assessment. The resulting chronic exposure estimates are not of concern to HED. The most highly exposed population was all infants (<1 y ear old) utilizing 23 % of the cPAD (s ee Table 3 below for a summary of the results ) . A chronic cancer dietary assessment was not conducted since it was determined that prometryn is not a possible human carcinogen.Prom etryn Dietary Exposure and Risk Assessment DP# 408528

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Page 7 of 12 **Table 3. Summary of Dietary (Food + Drinking Water)**  **Exposure and Risk for Prometryn**  **. Population Subgroup**  **1 Acute**  **Dietary 2**  **(95 th**  **Percentile) Chronic Dietary**  **Cancer Dietary**  **Exposure (m**  **g/kg/day) % aPAD**  **Dietary Exposure**  **(m g/kg/day)**  **% cPAD Dietary**  **Exposure (m**  **g/kg/day) Risk**  General U.S. Population -- -- 0.003426 8.6

N/A N/A All Infants (<1 year old) -- -- **0.009081 23**  Children 1 - 2 y ears old -- -- 0.005136 13 Children 3 - 5 y ears old -- -- 0.004274 11 Children 6 - 12 y ears old -- -- 0.003041 7.6 Youth 13 - 19 y ears old -- -- 0.002484 6.2 Ad ults 20 - 49 y ears old -- -- 0.003390 8.5 Ad ults 50 - 99 years old -- -- 0.003366 8.4 Fem ales 13 - 49 y ears old **0.020659 17**  0.003377 8.4 1 The values for the highest exposed population for each type of risk assessment is bolded. 2 An acute dietary endpoint (aPAD = 0.12 mg/kg/day) w as only determined for females 13 - 49 y ears old (see Table 2). The acute and chronic analy ses assumed tolerance - level residues, 100% CT, and DEEM (ver. 7.81) default processing factors . These anal ys es are considered very conservative and could be refined using anticipated - residue estimates (ARs), percent market share data, and/or empirical processing factors. However, at this time refinement is not necessary . **VIII. Conclusions** The a cute and chronic dietary exposure and risk assessments were conducted using DEEM FCID, Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEI A from 2003 through 2008 . An acute dietary risk analy ses w as conducted for females 13 - 49 y ears old only ; an acute endpoint of concern attributable to a single dose w as not identified for the general U.S. population . The acute analy si s assumed tolerance - level residues, 100% CT, and DEEM (ver. 7.81) default processi ng factors . The acute anal ys is also incorporated drinking water estimates provided b y EFED. The resulting acute food plus drinking water risk estimates for females 13 - 49 y ears old are not of concern to HED (<100% aPAD) at the 95 th percentile of the exposure distribution for females 13 - 49 y ears old. The resulting acute risk estimate is 17% of the aPAD at the 95 th percentile of the exposure distribution for females 13 - 49 y ears old. The chronic anal ys is assumed tolerance - level resid ues, 100% CT, DEEM (ver. 7.81) default processing factors, as well as drinking water estimates provided b y EFED. The resulting chronic risk estimates are not of concern to HED. The most highly exposed population was all infants (<1 year old) utilizing 23 % of the cPAD. **Attachments** Attachment 1: DEEM - FCI D Acute Food + Drinking Water Residue Input File. Attachment 2: DEEM - FCI D Acute Exposure Estimates for Females 13 - 49 Years Old. Attachment 3 : DEEM - FCI D Chronic Food + Drinking Water Residue Input File. Attachment 4 : DEEM - FCI D Chronic Exposure Estimates.Prom etryn Dietary Exposure and Risk Assessment DP# 408528

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Page 8 of 12 cc: S. Levy RDI: G. Kramer (RAB1): 19 - APR - 201 3 ; DE SAC Reviewers : 19 - APR - 201 3 S. Levy:S10953:PY - S:(703) 305 - 0783:7509P:RAB1Prom etryn Dietary Exposure and Risk Assessment DP# 408528

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Page 9 of 12 **Attachment 1: DEEM -**  **FCID Acute Food + Drinking Water Residue Input File.**  US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Acute analysis for PROMETRYN Residue file name: C: \ Documents and Settings \ slevy \ Desktop \ Prometryn \ 080805_ACUTE.R08 Analysis Date 04 - 17 - 2013 Residue f ile dated: 04 - 17 - 2013/15:28:20 Reference dose: aRfD = 0.12 mg/kg bw/day NOEL = 12 mg/kg bw/day Comment: 2E8052 - new uses on snap beans and dill

---------------------------------------------------------------------------------- EPA Crop Def Res Adj. Factors Comment Code Grp Food Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0601043000 6A Bean, snap, succulent 0.050000 1.000 1.0002E8052 0601043001 6A Bean, snap, succulent - babyfood 0.050000 1.000 1.0002E8052 0402076000 4B Cardoon 0.500000 1.000 1.000 0101078000 1AB Carrot 0.4500 00 1.000 1.000 0101078001 1AB Carrot - babyfood 0.450000 1.000 1.000 0101079000 1AB Carrot, juice 0.450000 1.000 1.000 0101084000 1AB Celeriac 0.050000 1.000 1.000 0402085000 4B Celery 0.500000 1.000 1.000 0402085001 4B Celery - babyfood 0.500000 1.000 1.000 0402086000 4B Celery, juice 0.500000 1.000 1.000 0402087000 4B Celtuce 0.500000 1.000 1.000 1901118000 19A Cilantro, leaves 9.000000 1.000 1.000 1901118001 19A Cilantro, leaves - babyfood 9.000000 1.000 1.000 2003128000 20C Cottonseed, oil 0.250000 1.000 1.000 2003128001 20C Cottonseed, oil - babyfood 0.250000 1.000 1.000 1902143000 19B Dill, seed 1.100000 1.000 1.0002E8052 1901144000 19A Dillweed 0.300000 1.000 1.0002E8052 0402152000 4B Fen nel, Florence 0.500000 1.000 1.000 0802234000 8BC Okra 0.050000 1.000 1.000 0401248000 4A Parsley, leaves 0.600000 1.000 1.000 1901249000 19A Parsley, dried leaves 1.500000 1.000 1.000 1901249001 19A Parsley, dried leaves - babyfood 1.500000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.450000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.250000 1.000 1.000 060225 9000 6B Pea, pigeon, succulent 0.250000 1.000 1.000 0402322000 4B Rhubarb 0.500000 1.000 1.000 0402367000 4B Swiss chard 0.500000 1.000 1.000 8601000000 86A Water, direct, all so urces 0.377400 1.000 1.000 8602000000 86B Water, indirect, all sources 0.377400 1.000 1.000Prom etryn Dietary Exposure and Risk Assessment DP# 408528

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Page 10 of 12 **Attachment 2: DEEM -**  **FCID Acute Exposure Estimates for**  **Females 13 to 49 Years Old.**  US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID ACUTE Analysis for PROMETRYN NHANES 2003 - 2008 2 - Day Residue file: 080805_ACUTE.R08 Adjustment factor #2 used. Analysis Date: 04 - 17 - 2013/15:29:05 Residue file dated: 04 - 17 - 2013/15:2 8:20 NOEL (Acute) = 12.000000 mg/kg body - wt/day RAC/FF intake summed over 24 hours Run Comment: "2E8052 - new uses on snap beans and dill"

=============================================================================== Summary calculations -- per capita:

--- 95th Percentile ---- --- 99th Percentile ---- --- 99.9th Percentile ---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Femal e 13 - 49: 0.020659 17.22 580 0.030331 25.28 395 0.042444 35.37 282Prom etryn Dietary Exposure and Risk Assessment DP# 408528

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Page 11 of 12 **Attachment 4: DEEM -**  **FCID Chronic Food + Drinking Water Residue Input File.** US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for PROMETRYN Residue file: C: \ Documents and Settings \ slevy \ Desktop \ Prometryn \ 080805_CHRONIC.R08 Adjust. #2 used Analysis Date 04 - 17 - 2013 Residue file da ted: 04 - 17 - 2013/15:24:32 Reference dose (RfD) = 0.04 mg/kg bw/day

---------------------------------------------------------------------------------- Food Crop Residue Adj. Factors EPA Code Grp Food Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ 0601043000 6A Bean, snap, succulent 0.050000 1.000 1.000 0601043001 6A Bean, snap, succulent - babyfo od 0.050000 1.000 1.000 0402076000 4B Cardoon 0.500000 1.000 1.000 0101078000 1AB Carrot 0.450000 1.000 1.000 0101078001 1AB Carrot - babyfood 0.4 50000 1.000 1.000 0101079000 1AB Carrot, juice 0.450000 1.000 1.000 0101084000 1AB Celeriac 0.050000 1.000 1.000 0402085000 4B Celery 0.500000 1.000 1.000 0402085001 4B Celery - babyfood 0.500000 1.000 1.000 0402086000 4B Celery, juice 0.500000 1.000 1.000 0402087000 4B Celtuce 0.500000 1.000 1.000 1901118000 19A Cilantro, leaves 9.000000 1.000 1.000 1901118001 19A Cilantro, leaves - babyfood 9.000000 1.000 1.000 2003128000 20C Cott onseed, oil 0.250000 1.000 1.000 2003128001 20C Cottonseed, oil - babyfood 0.250000 1.000 1.000 1902143000 19B Dill, seed 1.100000 1.000 1.000 1901144000 19A Dillweed 0.300000 1.000 1.000 0402152000 4B Fennel, Florence 0.500000 1.000 1.000 0802234000 8BC Okra 0.050000 1.000 1.000 0401248000 4A Parsley, leaves 0.600000 1.000 1.000 1901249000 19A Parsley, dried leaves 1.500000 1.000 1.000 1901249001 19A Parsley, dried leaves - babyfood 1.500000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.450000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.250000 1.000 1.000 0602259000 6B Pea, pigeon, succulent 0.250000 1.000 1.000 0402322000 4B Rhubarb 0.500000 1.000 1.000 0402367000 4B Swiss chard 0.500000 1.000 1.000 8601000000 86A Water, direct, all sources 0.157900 1.000 1.000 8602000000 86B Water, indirect, all sources 0.157900 1.000 1.000Prom etryn Dietary Exposure and Risk Assessment DP# 408528

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Page 12 of 12 **Attachment 5: DEEM -**  **FCID Chronic Exposure Estimates.** US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for PROMETRYN NHANES 2003 - 2008 2 - day Residue file name: C: \ Documents and Settings \ slevy \ Desktop \ Prometryn \ 080805_CHRONIC.R08 Adjustment factor #2 used. Analysis Date 04 - 17 - 2013/15:30:54 Residue file dated: 04 - 17 - 2013/15:24:32 Reference dose (RfD, Chronic) = .04 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.003426 8.6% Hispanic 0.003286 8.2% Non - Hisp - White 0.003521 8.8% Non - Hisp - Black 0.002813 7.0% Non - Hisp - Other 0.003980 10.0% Nursing Infants 0.003425 8.6% Non - Nursing Infants 0.011607 29.0% Female 13+ PREG 0.003193 8.0% Children 1 - 6 0.004520 11.3% Children 7 - 12 0.002890 7.2% Male 13 - 19 0.002344 5.9% Female 13 - 19/NP 0.002621 6.6% Male 20+ 0.003171 7.9% Female 20+/NP 0.003576 8.9% Seniors 55+ 0.003305 8.3% All Infants 0.009081 22.7% Female 13 - 50 0.003382 8.5% Children 1 - 2 0.005136 12.8% Children 3 - 5 0.004274 10.7% Chil dren 6 - 12 0.003041 7.6% Youth 13 - 19 0.002484 6.2% Adults 20 - 49 0.003390 8.5% Adults 50 - 99 0.003366 8.4% Female 13 - 49 0.003377 8.4%

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