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[ * ] = Certain information on this page has been redacted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
 EXHIBIT 10.66
   
 RE: Amendment No. 4 to the Drug Discovery Collaboration Agreement
  InterMune Array Agreement Amendment Effective Date
 1.
    
    The first sentence of Section 5.1.1 of the Agreement is hereby amended in its entirety to
read as follows:InterMune agrees to pay Array research funding for the conduct of the Research
Collaboration quarterly, in advance, in an amount equal to one quarter (1/4) of [ * ] (or,
if lesser, the number of Array FTEs scheduled in the Research Plan to be provided by Array
in the upcoming quarter), multiplied by the applicable Array FTE Rate (as defined below in
Section 5.1.2).2.
    
    The last sentence of Section 5.1.1 of the Agreement is hereby amended in its entirety to read
as follows:In no event shall InterMune be required to fund a greater number of Array FTEs in any
calendar quarter than one quarter (1/4) of [ * ], or, if lesser, those provided in the
Research Plan for Array to provide in such quarter.3.
    
    Array hereby acknowledges that (a) it devoted [ * ] to the conduct of the Research
Collaboration during November 2004, and (b) it will devote [ * ] to the conduct of the
Research Collaboration during December 2004. The Joint Research Committee shall amend the
Research Plan to reflect such number of FTEs. Upon execution of this Amendment No. 4,
InterMune shall pay to Array an amount equal to [ * ] of the current FTE rate to fund such
FTEs during such period.




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4.
    
    The Agreement is hereby amended to insert a new Section 4.2.1, and, as a result, the old
sections 4.2.1, 4.2.2, 4.2.3 and 4.2.4 are hereby renumbered to be new Sections 4.2.2, 4.2.3,
4.2.4 and 4.2.5:4.2.1 Immediately upon receipt by Array of a cash payment of [ * ] with respect to a
particular Lead Compound, Array shall [ * ]. It is understood and agreed that the
provisions of this Section 4.2.1 shall not apply to any [ * ], nor shall such provisions
affect InterMunes license under Section 4.2.2. Array hereby acknowledges the prior payment
of a cash payment of [ * ] with respect to [ * ], and shall immediately following the
Amendment Effective Date [ * ].5.
    
    Section 4.3 of the Agreement is hereby amended in its entirety to read as follows:Subject to the terms and conditions of this Agreement, including, without limitation, the
limitation on Arrays rights hereunder set forth in the last sentence of this Section 4.3,
InterMune hereby grants to Array a worldwide, non-exclusive, transferable, royalty-free
right and license, with the right to grant and authorize sublicenses, under InterMunes
interest in the Collaboration Technology, to exploit the same other than in the research,
development, making, having made, using, importing, offering for sale or selling Hit
Compounds, Lead Compounds or Products worldwide. To the extent that any Collaboration
Technology included in the license granted to Array under this Section 4.3 comprises a claim
of a patent or patent application, the subject matter of which was invented solely by Array
personnel, Arrays license under such patent claim(s) to exploit the same other than in the
research, development, making, having made, using, importing, offering for sale or selling
Hit Compounds, Lead Compounds or Products worldwide shall be exclusive. Notwithstanding the
foregoing, Arrays license under this Section 4.3 shall not include any right to make, have
made, use or sell any chemical entity, the composition of matter of which is claimed in a
Collaboration Patent assigned by Array to InterMune pursuant to Section 4.2.1 above.6.
    
    Section 4.6 of the Agreement is hereby amended by adding, in the parenthetical, following the
words in exercise of the the following phrase: intellectual property rights assigned or
and replacing 4.2.1 with 4.2.7.
    
    Section 5.2 of the Agreement is hereby amended by replacing the last sentence with the
following:For clarity, this means that as between the Parties, InterMune is responsible for the costs
of activities in exercise of its rights under Section 4.2.8.
    
    Section 5.4.3 of the Agreement is hereby amended by adding the following as the last
sentence:[ * ].9.
    
    Section 8.1.2 of the Agreement is hereby amended by replacing the last sentence with the
following:
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Such joint ownership shall be in accordance with the default rights enjoyed by co-inventors
under U.S. patent law in the absence of a written agreement to the contrary (throughout the
world to the maximum extent permitted by law), such that, without limitation and except as
restricted by the assignment provisions of Section 4.2, licenses granted in Sections 4.1 and
4.2, financial commitments set forth in Article 5 and prosecution and enforcement provisions
set forth in this Article 8, each Party may practice the subject matter of the jointly owned
Collaboration Patents without a duty of accounting to the Party.10.
    
    The Agreement is amended by including a new Section 8.1.4 of the Agreement:8.1.4. Array shall, and shall cause its employees and agents to, promptly execute all
papers and instruments as are necessary (i) to fully effect the assignment of ownership of
Collaboration Patents provided for in Section 4.1.2, and (ii) to enable InterMune to record
any such assignment in any country.11.
    
    Section 8.2.1 of the Agreement is hereby amended by adding the following sentence at the end
thereof:InterMune shall use reasonable efforts to prosecute the Collaboration Patents so that there
will be claims specifically directed to the making, having made, use and sale of
compositions of matter, including, without limitation, Hit Compounds, Lead Compounds and
Products, and (as appropriate based on the disclosure) other claims in separate
Collaboration Patents specifically directed to areas included within Arrays license set
forth in Section 4.3, such as, for example, by the filing of divisional patent
applications.12.
    
    Section 8.2.1 of the Agreement is hereby amended by adding the following sentence as the
third sentence of such Section:Notwithstanding the foregoing, following assignment of a Collaboration Patent pursuant to
Section 4.2.1, InterMune shall only be required to keep Array fully informed as to patent
matters relating to claims contained in any such Collaboration Patent as to which Array has
license rights under Section 4.3.13.
    
    The Agreement is hereby amended to include the following Section 8.3.3:8.3.3 Array. In the event that a Party believes a Third Party is infringing any
Collaboration Patent right included within the license granted Array pursuant to Section 4.3
above, Array shall have the right, but not the obligation, to take reasonable legal action
to enforce such Collaboration Patent and defend any declaratory judgment action relating to
such infringement, at its sole cost and expense. Array shall keep InterMune reasonably
informed of the progress of any such enforcement action as it relates to such Collaboration
Patent, and Array shall not enter into any settlement or other agreement or make any other
admission that relates to the validity or enforceability of any such Collaboration Patent
owned or Controlled by InterMune without the prior written consent of InterMune, which
consent shall not be unreasonably withheld. Any amount recovered by Array in an action
brought pursuant to this Section 8.3.3 shall be retained by Array.
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To the extent that InterMune has to be joined in any legal action pursuant to this Section
8.3.3, InterMune shall be entitled to employ counsel of its choosing and to reimbursement by
Array for reasonable attorneys fees and expenses incurred in connection with such
activities.14.
    
    Section 8.3.3 of the Agreement is hereby renumbered to be new Section 8.3.4, and is hereby
amended by adding, at the end of the third line thereof, after the phrase Collaboration
Patent or Preparatory Patent, the following phrase: pursuant to Section 8.3.2.15.
    
    Section 12.2 of the Agreement is hereby amended by adding the following sentence at the end
thereof:Any such dispute related to payment obligations or alleged breaches thereof shall be
resolved by binding arbitration in accordance with Section 13.12.16.
    
    Section 12.4 of the Agreement is hereby deleted in its entirety.17.
    
    Section 12.5.3 of the Agreement is hereby amended in its entirety to read as follows:12.5.3  Survival Sections.  Articles 1, 6, 9, 11 and 13 and
Sections 2.7 and 8.1.2 of this Agreement shall survive the expiration
or termination of this Agreement for any reason.  In the event of termination
by InterMune under Section 12.2 or 12.3, Section 4.1, 4.2, 5.3, 5.4 and 8.2.1
shall survive such termination in addition to the above-referenced Articles and
Sections; InterMune shall have the [ * ] right to enforce the Collaboration Patents
and Primary Preparatory Patents (as defined in Section 8.2.2) assigned or licensed to
InterMune hereunder against infringing products that would be competitive with Products;
and Article 9 shall survive until five (5) years after the last payment obligation hereunder
expires. In the event of termination by Array under Section 12.2 or 12.3, Sections 4.3, 5.3
and 5.4 shall survive such termination in addition to the above-referenced Articles and
Sections; and InterMune shall immediately grant to Array a worldwide, non-exclusive, fully
paid-up license under InterMunes interest in the Collaboration Patents previously
assigned to InterMune pursuant to Section 4.1.2 to research, develop, make, have made,
use, import, offer for sale and sell Hit Compounds, Lead Compounds and Products; provided
 that, to the extent that any such assigned Collaboration Patent was invented solely by
Array personnel, Arrays license under such Collaboration Patent shall be exclusive.
InterMune shall ensure that any licenses of Collaboration Patents granted by InterMune or
its Affiliates to third parties are made subject to Arrays license grant-back rights set
forth in this Section 12.5.3.18.
    
    The Agreement is hereby amended to include the following Section 13.12 and, as a result, the
old sections 13.12, 13.13, 13.14, 13.15 and 13.16 are hereby renumbered to be new Sections
13.13, 13.14, 13.15, 13.16 and 13.17:13.12 Short-Form Arbitration. If the Parties do not agree upon a payment dispute under
Section 12.2, then such matters in issue shall be determined by binding arbitration
conducted pursuant to this Section 13.12 by one (1) arbitrator. In such arbitration, the
arbitrator shall be a mutually acceptable, independent, conflict-free individual not
affiliated with either Party, with scientific, technical and regulatory experience with
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respect to development of pharmaceutical products. If the Parties are unable to agree on an
arbitrator, the arbitrator shall be an independent expert meeting the criteria set forth in
the immediately preceding sentence selected by the American Arbitration Association within
seven (7) days of being approached by a Party. Within fifteen (15) days of designation of
the expert hereunder, each Party shall prepare and submit to the expert and to the other
Party a written statement setting forth its position with respect to the substance of the
dispute. Each Party shall have an additional ten (10) days from receipt of the other
Partys submission to submit a written response thereto. The expert shall have the right to
meet with the Parties, either alone or together, as necessary to make a determination. The
arbitration shall take place in the county in which the executive offices of the Party which
is alleged to be in breach are situated. The expert shall select one of the Partys
positions as his decision, and shall not have authority to render any substantive decision
other than to so select the position of either InterMune or Array. The costs of such
arbitration (including without limitation, the costs of the expert) shall be shared equally
by the Parties, and each Party shall bear its own expenses in connection with such
arbitration. Any such arbitration shall to the greatest extent possible, be concluded
within sixty (60) days after designation of the expert hereunder.19.
    
    Section 13.15 of the Agreement is hereby amended by adding the following phrase at the
beginning thereof:Except as set forth in Sections 12.2 and 13.12 of this Agreement,
      
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Acknowledged and Agreed:ARRAY BIOPHARMA, INC.By:
    
    /s/ David L. SnitmanName:
    
    David L. SnitmanTitle:
    
    COODate:
    
    12-8-04cc:
    
    Paul Resnick, InterMuneGeneral Counsel, Array BioPharma
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