Sixth Amendment to Development and Supply Agreement



 Exhibit 10.8 
 Confidential treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated as [***]. A complete
version of this exhibit has been filed separately with the Securities and Exchange Commission. 
 [***] 

SIXTH AMENDMENT 
 TO DEVELOPMENT AND SUPPLY AGREEMENT 
 Effective as of
date of the last signature below, Abbott Laboratories, an Illinois corporation having a principal place of business at 100 Abbott Park Road, Abbott Park, Illinois 60064-3500 (“Abbott”), and Seattle Genetics, Inc., a Delaware corporation
having a principal place of business at 21823 – 30th
Drive Southeast in Bothell, Washington 98021 (“Seattle Genetics”) (individually the “Party” or collectively the “Parties”) agree to the following terms and conditions (“Sixth Amendment”) as set forth below.

 WHEREAS, the Parties entered into a Development and Supply Agreement with an Effective Date of February 23, 2004
for the manufacture of a chimeric anti-CD30 AC10 monoclonal antibody known as cAC10 Bulk Drug Substance (the “Original Agreement”), which also constitutes the antibody component of SGN-35 and the Parties subsequently entered into five
amendments to the Original agreement (the “First Amendment”, “Second Amendment”, “Third Amendment”, “Fourth Amendment” and “Fifth Amendment”, respectively. Collectively the Original Agreement, the
First Amendment, the Second Amendment, the Third Amendment, the Fourth Amendment and the Fifth Amendment are hereinafter referred to as the “Agreement”); and 
 WHEREAS, the Parties desire to further amend the Agreement as herein provided as of the date hereof. 
 NOW, THEREFORE, in consideration of the mutual covenants and agreements contained here and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged,
the Parties agree as follows: 
 1. Incorporation of the Agreement. All capitalized terms which are used but not
otherwise defined herein shall have the same meanings as set forth in the Agreement, and the Agreement, to the extent not inconsistent with this Sixth Amendment, is incorporated herein by this reference as though the same was set forth in its
entirety. To the extent any terms and provisions of the Agreement are inconsistent with the amendments set forth in Paragraphs 2 and 3 below, such terms and provisions shall be deemed superseded hereby. Except as specifically set forth herein, the
Agreement shall remain in full force and effect and its provisions shall be binding on the parties. 
 2. Process Development
Work. The Parties agree that Abbott shall perform the activities set forth in Stage 6a of Attachment 1 hereto pursuant to the terms and conditions of the Agreement. 
 3. Payment Schedule. As compensation for the activities to be performed by Abbott pursuant to Attachment 1 hereto, Seattle Genetics shall pay to Abbott the price established for each project stage
on the dates set forth in Attachment 2. Billings associated with this Sixth Amendment may be combined on the same invoice with other, regular Payment Schedule charges. 
 4. Project References. All references to the Project set forth in the Agreement, with the exception of the Payment Schedule and Facility Reservation Fee for the Project, shall also be deemed to
apply to the activities performed by Abbott, pursuant to this Sixth Amendment. 
 6. Effectuation. The amendment to the
Agreement contemplated by this Sixth Amendment shall be deemed effective as of the last date written below upon the full execution of this Sixth 







 
Amendment and without any further action required by the parties hereto. There are no conditions precedent or subsequent to the effectiveness of this Sixth Amendment. All terms and conditions set
forth in Agreement that are not amended hereby shall remain in full force and effect. Any term of this Sixth Amendment may be amended with the written consent of both parties. From the date hereof, any reference to the Agreement shall be deemed to
refer to the Agreement as amended by this Sixth Amendment. 
 7. Counterparts. This Sixth Amendment may be executed in
two or more counterparts, each of which shall be deemed to be an original, but all of which together shall constitute one and the same instrument. One or more counterparts of this Sixth Amendment may be delivered by facsimile, with the intention
that delivery by such means shall have the same effect as delivery of an original counterpart thereof. 
 8. Entire
Agreement. This Sixth Amendment and exhibits hereto are the product of both of the parties hereto, and together with the Agreement and exhibits thereto constitute the entire agreement between such parties pertaining to the subject matter hereof,
and merge all prior negotiations and drafts of the parties with regard to the transactions contemplated herein. 
 IN WITNESS
WHEREOF, the parties have executed this Second Amendment as of the dates set forth below. 
  

									
	ABBOTT LABORATORIES	 	 	 	SEATTLE GENETICS, INC.
					
	By:	 	 /s/ Keith Kentala
	 		 	By:	 	 /s/ Clay B. Siegall

					
	Name:	 	 Keith Kentala
	 		 	Name:	 	 Clay B. Siegall

					
	Title:	 	 General Manager, Commercial Operations
	 		 	Title:	 	 President & CEO

					
	Date:	 	 11/18/2010
	 		 	Date:	 	 11/8/2010


 [***] Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission.
Confidential treatment has been requested with respect to the omitted portions. 

  

					
	11/3/2011	  	2	  	CONFIDENTIAL









 ATTACHMENT 1 
 PROJECT SCOPE 
 [***] 

[***] Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 







 ATTACHMENT 2 
 PAYMENT SCHEDULE 
 [***] 

[***] Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions.