Sustainable Futures

Summary Assessment

Using

P2 Framework Models

Chemical Assessed:

4,7-Methano-1H-indene-1-propanal, octahydro- and 

4,7-Methano-1H-indene-2-propanal, octahydroCAS Registry Number:

[1464989-16-9 and 1467039-69-5]

Participant Name:

Paul Sterchele

Senior Regulatory Toxicologist

Global Regulatory Affairs

International Flavors & Fragrances Inc.

Date of Assessment: 

December 2014

This document was developed to help compile estimation results from U.S. EPA OPPT’s P2 

Framework Models and is used by OPPT during Sustainable Futures (SF) training described at 

www.epa.gov/oppt/sf. Participants in the voluntary Sustainable Futures Program are asked to 

submit the information contained in this assessment along with their SF PMNs in their choice of 

format.

Use of this specific format is not mandatory. 
2

Record ID: CAS No. 1464989-16-9 & 

1467039-69-5

Chemical Structure

 

+

 (60 – 70%)* 

O 

 (15 - 25%) 

 

 

 

 

Is this a representative structure? Yes

MW: 192.15

MF: C13H20O

Physical Form: Liquid

Submitter: International Flavors & 

Fragrances Inc.

Trade Name: To Be Determined

Use: Fragrance Ingredient

Production Volume: 1000 kg/yr 

(Projected – non-US Manufacturing) 

SMILES: O=CCCC2CCC3C1CCC(C1)C23 & O=CCCC2CC3C1CCC(C1)C3(C2)

Name: 4,7-Methano-1H-indene-1-propanal, octahydro- & 4,7-Methano-1H-indene-2-propanal, octahydroSynonyms: None

*Structure of primary isomer /constituent was used for completing the Sustainable Futures summary assessment, as the minor isomer modeling 

values produced similar output as the primary constituent.

O
3

SUSTAINABLE FUTURES SUMMARY:

Concern Level HIGH MODERATE LOW

Persistence XXX

Bioconcentration XXX

Cancer Health Hazard Low-Moderate

Non-Cancer Health Hazard XXX

Aquatic Toxicity Hazard XXX

Is the chemical predicted to be a PBT by PBT Profiler? No

Overall Hazard Concern Human Health Hazard: Low

Aquatic Hazard: High

Overall Risk Human Health Risk: Low

Aquatic Risk: Low
4

CAS No. 1464989-16-9 Submitter: International Flavors & Fragrances Inc.

PHYSICAL/CHEMICAL PROPERTIES:

Melting Point (deg C) < -82 (< 191K) (OECD 102, IFF 2014)1

Attachment ID# 007

Boiling Point (deg C) 269.89 (EPISuite v4.11)

Vapor Pressure (mm Hg)

8.4 x 10-3 @ 20°C; 1.4 x 10-2 @ 25°C (OECD 104, IFF 

2014)

1

Attachment ID# 007

Water Solubility (g/L) 0.0134 at 20°C (OECD 105, IFF 2014)

1

Attachment ID# 007

Octanol/Water Partition Coefficient - Log Kow

3.9 – 4.8 (OECD 117, IFF 2014)1

Attachment ID# 007

ENVIRONMENTAL TRANSPORT AND FATE:

Transport

Henry’s Law Constant – HLC (atm-m

3

/mol) 1.169 x 10-4 (EPISuite v4.11)

Soil Adsorption Coefficient – Log Koc 

2.591 (MCI method) or 3.351 (Kow method)

(EPISuite v4.11)

Bioconcentration Factor – BCF (L/kg wet-wt) 682.4 (EPISuite v4.11)

Persistence

Probability of Rapid Biodegradation Yes (EPISuite v4.11)

Ultimate Biodeg Model 2.7965 weeks (EPISuite v4.11)

Primary Biodeg Model 3.7669 days (EPISuite v4.11)

Ready Biodegradability (MITI Model) Yes (EPISuite v4.11)

Atmospheric Half-life 3.332 hrs (EPISuite v4.11)

Hydrolysis Half-life Cannot be estimated (EPISuite v4.11)

Volatilization Half-life for Model River 3.376 days (81.01 hrs) (EPISuite v4.11)

Volatilization Half-life for Model Lake 41.67 days (1000 hrs) (EPISuite v4.11)

Removal in Sewage Treatment Plant* Total predicted removal is 70.44% (EPISuite v4.11)

Experimental Data

Ready biodegradation test (OECD 301D, IFF 2014), NOT 

readily biodegradable under the test conditions with 8.48% 

degradation after 28 days.2

Attachment ID# 014

Byproducts

Degradation Products Not measured or analyzed

Metabolites Not measured or analyzed

* Unless experimental data indicate otherwise, the maximum value used by EPA will be 95% removal.
5

CAS No. 1464989-16-9 Submitter: International Flavors & Fragrances Inc.

ECOTOXICITY:

ECOSAR Class Aldehydes (Mono)

Acute Toxicity

Fish LC5O

0.376 mg/L, 96-hr (ECOSAR v1.11)

Experimental Data (Draft report): The LC50 (96-hr) of the 

test substance in zebra-fish species was 3.525 mg/L based 

on nominal concentrations, and 0.913 mg/L based on the 

geometric means of measured concentrations.3

Attachment ID# 021

Daphnid LC5O

0.150 mg/L, 48-hr (ECOSAR v1.11)

No experimental data. Read across to analog* CAS 86803-

90-9.

Daphnia magna Acute Toxicity, 1995. Research Institute 

for Fragrance Materials (RIFM) Database Location 30033, 

Sub-Reference 04/044.

Under the conditions of the study, conducted according to 

OECD Guidelines for Testing of Chemicals (1984) No. 202 

"Acute Immobilisation Test and Reproduction Test" per 

Method C.2 of Commission Directive 92/69/EEC (Annex 

V of Council Directive 67/548/EEC), the 48 hour EC50 for 

the test material = 5.5 mg/l (95% confidence limits = 4.5 –

6.7 mg/L).

Result details:

An Acute Toxicity study was conducted on 20 Daphnia 

magna/concentration for 48 hours under static conditions at 

test concentrations of: 1, 1.8, 3.2, 5.6, 10, 18, 32, 56 and 

100 mg/L. The NOEL was determined to be 1.8 mg/L and 

the EC50 for 48 hours was calculated to be 5.5 mg/L.

Green Algae EC5O

0.432 mg/L, 96-hr (ECOSAR v1.11)

No experimental data. Read across to analog* CAS 86803-

90-9.

Algae Inhibition Test, 1995. Research Institute for 

Fragrance Materials (RIFM) Database Location 30034, 

Sub-Reference 05/045.

Under the conditions of the study, conducted according to 

OECD Guidelines for Testing of Chemicals (1984) No. 201

"Alga Growth Inhibition Test" per Method C.3 of 

Commission Directive 92/69/EEC (Annex V of Council 
6

Directive 67/548/EEC), the EbC50 value (biomass reduction 

at 72 hours) was determined to be 1 mg/L, and the ErC50

value (growth rate reduction at 24 – 48 hours) was 

determined to be 1.7 mg/L.

Result details:

The effect of the test substance on growth inhibition was 

studied in green algae exposed for up to 72 hours to test 

concentrations of: 0.625, 1.25, 2.5, 5.0, and 10 mg/L. The 

NOEL was determined to be 0.246 mg/L (based on 

measured test concentrations), the EbC50 value = 1 mg/L, 

and the ErC50 value = 1.7 mg/L.

Chronic Toxicity

Fish ChV 0.019 mg/L (ECOSAR v1.11)

Daphnid ChV 0.037 mg/L (ECOSAR v1.11)

Green Algae ChV 0.289 mg/L (ECOSAR v1.11)

Overall Hazard Concern for Aquatic Toxicity

Based on the predicted acute and chronic values for aquatic 

toxicity, the aquatic hazard concern is high. However, 

based on the ratios of the Acute PEC to Acute COC, and 

the ratios of Chronic PEC to Chronic COC, the risk to the 

aquatic environment is expected to be low. See 

Worksheets #2 and #3 below for details.

Lowest Chronic COC (lowest ChV/10) – used as input 

to determine Aquatic Exposure in E-FAST 2 ppb

CANCER HEALTH EFFECTS:

Experimental data None

OncoLogic Results

The level of concern when the anticipated route of 

exposure is inhalation is MARGINAL.

The level of concern when the anticipated route of 

exposure is dermal is LOW-MODERATE.

Overall Hazard Concern for Carcinogenicity LOW 

NON-CANCER HEALTH EFFECTS:

Acute Toxicity

No data. Read across to analog* CAS 86803-90-9

1) Acute Dermal Toxicity Study in Rabbits, 1985

(RIFM Location 30022, Sub-Reference11/01)6

Under the conditions of the study, conducted 

according to Annex V of the EEC Commission 

Directive, the dermal LD50 for the test material is 

greater than 2000 mg/kg/day.

Study details:

An acute dermal limit toxicity study was conducted 

with five male and five female, New Zealand white 

rabbits. A single dose of 2000 mg/kg/day of 

undiluted test material was applied on the dorsal 

skin under semi-occlusive patches for 24 hours.

Observations for systemic effects were made at 
7

frequent intervals (at least hourly for the first five 

hours) after dosing and then daily for 14 days after. 

All animals were sacrificed after 14 days and 

examined for gross pathology. Irritation was 

evaluated as part of the gross necropsy.

No systemic effects or macroscopic changes, other 

than skin irritation, were observed. The test 

substance had no toxic effect when applied to the 

skin of the rabbit. The results of this study 

demonstrate that the LD50of the test substance on 

single application to the skin of the rabbit is > than 

2000 mg/kg/day. 

2) Acute Oral Toxicity Study in Rats, 1989

(RIFM Location 30021, Sub-Reference 11/22)

7

Under the conditions of the study, the oral LD50

for the test material is estimated to be 2800 

mg/kg/day.

Study details:

An acute oral toxicity study was conducted for 14 

days on six Sprague-Dawley rats, three males and 

three females. The rats were fasted for 24 hours 

before test material was administered by oral 

gavage dosing at the following concentrations:

 

Dose (mg/kg bw) Effect

 625 No effects

1250 No effects

2500 2 of 6 dead; Lethal

2800 Calculated LD50 (95% confidence 

interval of 2100 to 

3760mg/kg)

5000 6 of 6 dead; Lethal

The animal’s weights were recorded right after 

dosing and after the 7th and 14th day. All animals 

were observed for signs of illness and death for the 

entire study period.

Irritation

Modified Shelanski-Shelanski Human Patch Test (HRIPT), 

IFF 2014. The PMN substance FRET 09-0536-01 did NOT

demonstrate a potential for eliciting dermal irritation at 2% under occlusive patch test conditions.8

Attachment ID# 09

Skin Sensitizer

Modified Shelanski-Shelanski Human Patch Test (HRIPT), 

IFF 2014. The PMN substance FRET 09-0536-01 did NOT

demonstrate a potential for eliciting dermal sensitization at 2% under the occlusive patch test conditions.8

Attachment ID# 09
8

KeratinoSens Assay, IFF 2014. The PMN substance 

Fragrance Research Chemical TM 09-0536-01 was 

predicted to be a non-sensitizer in this in vitro cell culture 

system.9

Attachment ID# 010

Direct Peptide Reactivity Assay, IFF 2014. The PMN 

substance Fragrance Research Chemical TM 09-0536-01 

was predicted to be a potential sensitizer based on its low 

reactivity with the peptides in this in vitro system.10

Attachment ID# 011

Reproductive Effects No Data Available

Developmental Effects No Data Available

Immune System Effects No Data Available

Neurotoxicity No Data Available

Genotoxicity

The PMN substance FRET 09-0536 was non-clastogenic to 

human lymphocytes in vitro under the conditions of a 

chromosome aberration test, following Test Guideline 

OECD 473.11

Attachment ID# 12

Mutagenicity

The PMN substance FRET 09-0536 was non-mutagenic 

under the conditions of a bacterial reverse mutation test in 

strains of Salmonella typhimurium and Escherichia coli, 

following Test Guideline OECD 471.12

Attachment ID# 13

Systemic Effects

No data. Read across to analog* CAS 86803-90-9

4 Week, Subchronic (Gavage) Toxicity Study in the Rat

(RIFM Location 30030, Sub-Reference 12/13 )13

Under the conditions of the study, the Lowest-ObservedEffect Level (LOEL) for the test material is 500

mg/kg/day. There were no treatment-related changes 

observed with respect to survival, bodyweight gain,

hematology, food consumption or macroscopic findings. 

However, absolute and relative liver weights were 

statistically increased in all treated female groups relative 

to controls, leading to the conclusion that the No Observed 

Effect Level is < 500 mg/kg/day.

Study details: 

A 4 week toxicity study was conducted on rats (male and 

female). Three groups of 5 rats per dose received the test 

material administered once daily via oral gavage for the 

length of the study, at doses of 500, 750 or 1000 

mg/kg/day. A fourth group consisted of control animals 

that were administered vehicle. Daily observations and 

weekly body weights and food consumptions were 

recorded throughout the study. Blood was collected at the 

end of week four. 

Overall Hazard Concern for Non-Cancer 

Health Effects LOW
9

Note: 

*analog: 4,7-Methano-1H-indene-2-carboxaldehyde, octahydro-5-methoxyCAS# 86803-90-9

O O

CAS No. 1464989-16-9 Submitter: International Flavors & Fragrances Inc.

INDUSTRIAL OPERATIONS INFORMATION

Operation Name Fragrance oil compounding Number of sites 1

Location International Flavors & Fragrances Inc.

600 State Highway #36, Hazlet, New 

Jersey 07730

Operating Days 

Per Year 

250 (maximum; based 

on estimation of 

2 kg/batch, 2 batch/day)

INDUSTRIAL RELEASE SUMMARY (ChemSTEER)

Media Operation Daily 

Release 

(kg/site-day)

Release 

Days 

per 

Year

No of Sites 

of Release

Total Annual 

Releases 

(kg/year -all sites)

Release site information 

(NPDES No. or SIC Code)

Landfill

Equipment 

cleaning 

wastewater 

on-site 

treatment 

(sludge)

5.6E-3 250 1 1.4 NPDES #NJ

0108707/NJ0021016

Passaic Valley Sewerage 

Commissions (PVSC)

Water

Equipment 

cleaning at 

IFF

2.3E-3 250 1 0.58

NPDES #NJ0024708

Bayshore Regional 

Sewerage Authority 

(BRSA)

Cleaning 

drums used to 

transport raw 

material at 

drum 

reconditioning 

contractor’s 

site

0.62 5 1 3.1

NPDES#: NJ0020141

The Middlesex County 

Utility Authority

Air

Equipment 

cleaning at 

IFF

1.9E-4 250 1 0.048 SIC 2844 – Soaps, 

detergent, etc. manufacture

Sampling 

product at IFF 2.8E-8 250 1 7.0E-6

SIC 2844 – Soaps, 

detergent, etc. manufacture
10

Cleaning 

drums used to 

transport raw 

material at 

drum 

reconditioning 

contractor’s 

site

9.7E-9 5 1 4.9E-8

SIC 5093 – Scrap and 

Waste Materials

Unloading raw 

material from 

drums at IFF

5.8E-8 250 1 1.4E-5

SIC 2844 – Soaps, 

detergent, etc. manufacture

Loading 

product into 

containers at 

IFF

7.2E-8 250 1 1.8E-5

SIC 2844 – Soaps, 

detergent, etc. manufacture

Equipment 

cleaning

wastewater 

on-site 

treatment 

(stripping to 

air)

1.9E-4 250 1 0.048 SIC 2844 – Soaps, 

detergent, etc. manufacture

OCCUPATIONAL EXPOSURE SUMMARY

Operation Route Potential 

Dose Rate

(mg/day)

Days/yr Workers Cancer 

LADD 

(mg/kg-day)

Chronic 

ADD

(mg/kg-day)

Acute

APDR

(mg/kg-day)

Cleaning drums 

used to transport 

raw material

Inhalation 

(Worst case) 1.40E-4 5 1 1.6E-8 2.7E-8 2.0E-6

Dermal 

(High end) 1.8E3 6 1 0.24 0.41 25.0

Sampling product Inhalation 

(Worst case) 4.0E-3 250 1 2.2E-5 3.9E-5 5.7E-5

Dermal

(High end) 8.82 250 1 0.049 0.086 0.130

Unloading liquid 

raw material from 

drums

Inhalation 

(Worst case) 8.3E-3 250 1 4.7E-5 8.2E-5 1.2E-4

Dermal 

(High end) 1.8E3 250 1 9.9 17.0 25.0

Loading liquid 

product into 

containers

Inhalation 

(Worst case) 0.01 250 1 5.8E-5 1.0E-4 1.5E-4

Dermal

(High end) 18.0 250 1 0.099 0.170 0.250

Total number of Workers – All Sites 45
11

GENERAL POPULATION EXPOSURE SUMMARY (E-FAST)

Cancer LADDpot

(mg/kg/day) LADCpot Acute ADRpot(mg/kg/day)

Drinking Water Drum Cleaning 3.16E-7 2.43E-5 mg/L Not Applicable

Vessel Cleaning 5.87E-8 4.52E-6 mg/L Not Applicable

Fish Ingestion Drum Cleaning 2.12E-8 2.26E-4 mg/kg 2.72E-4

Vessel Cleaning 7.48E-9 7.98E-5 mg/kg 2.61E-6

Fugitive 

Emissions

Drum Cleaning 3.41E-2 0.19 mg/m3

1.00

Vessel Cleaning 3.41E-2 0.19 mg/m3

1.00

Liquid Sampling 3.41E-2 0.19 mg/m3

1.00

Unloading Liquid 

Material from Drums 3.41E-2 0.19 mg/m3

1.00

Loading Liquid Product 

into Containers 3.41E-2 0.19 mg/m3

1.00

Dermal –

Consumer Use

General Purpose 

Cleaner 2.58E-3 Not Applicable 1.07E-1

Laundry Detergent 2.58E-3 Not Applicable 1.07E-1

Bar Soap 1.64E-2 Not Applicable 6.15E-1

Inhalation –

Consumer Use

General Purpose 

Cleaner 1.35E-2 7.30E-2 mg/m3

6.42E-1

Laundry Detergent 3.94E-4 1.89E-3 mg/m3

7.05E-2

AQUATIC EXPOSURE SUMMARY

Lowest Acute COC – Aquatic Exposure 30 ppb (Daphnid)

Lowest Chronic COC – Aquatic Exposure 2 ppb (Fish)

Predicted Environmental Concentration (Acute PEC) 0.11 ppb

Predicted Environmental Concentration (Chronic PEC) 0.0571 ppb

PEC Exceeds Chronic COC (days / year) 0 days

RISK ASSESSMENT CALCULATIONS:

Acute Risk to Aquatic Organisms

LOW concern.

Based on ratio of Acute PEC to Acute COC. See below 

Worksheet #1 for details.

Chronic Risk to Aquatic Organisms

LOW concern.

Based on ratio of Chronic PEC to Chronic COC. See below 

Worksheet #2 for details.

MOE – Acute Occupational Exposure

LOW concern.

Dermal and Oral LD50 values are > 50 mg/kg for an analog 

material (4,7-Methano-1H-indene-2-carboxaldehyde, 

octahydro-5-methoxy-; CAS# 86803-90-9).

When acute toxicity studies indicate LD50 values are > 50 

mg/kg for a chemical, there is no need to calculate MOE 

for acute risk, and it poses a low concern based on SF 

Assessment Guidance. 

Given the fact that all workers at the IFF facility are 

required to have personal protection equipment such as 

chemical resistant gloves and safety glasses, preventing 

direct dermal contact with the notified substance, the risk is 
12

anticipated to be Low. Furthermore, the production process 

of the notified substance is always performed with exhaust 

ventilation, minimizing the inhalation exposure.

MOE – Chronic Occupational Exposure

POTENTIAL concern if not wearing PPE.

LOW concern with proper PPE.

Based on ChemSTEER estimated LADD values for 

inhalation and dermal exposure to the notified material, and 

read across to LOEL value for systemic effects of the 

analog material 4,7-Methano-1H-indene-2-carboxaldehyde, 

octahydro-5-methoxy- (CAS# 86803-90-9). See below 

Worksheet #3 for details.

Considering all workers at the IFF facility are required to 

wear personal protection equipment such as chemical 

resistant gloves and safety glasses, thus preventing direct 

dermal contact with the notified substance, the anticipated 

risk is LOW.

In addition, the production process of the notified substance 

is always performed with exhaust ventilation, minimizing 

the inhalation exposure as well.

MOE – Acute General Population Exposure

LOW concern. 

Dermal and Oral LD50 values are > 50 mg/kg for an analog 

material (4,7-Methano-1H-indene-2-carboxaldehyde, 

octahydro-5-methoxy-; CAS# 86803-90-9).

When acute toxicity studies indicate LD50 values are > 50 

mg/kg for a chemical, there is no need to calculate MOE 

for acute risk, and it poses a low concern based on SF 

Assessment Guidance. 

MOE – Chronic General Population Exposure

LOW concern.

Based on LADDpot for all exposure scenarios and routes 

combined and LOEL for systemic effects of analog 

material (4,7-Methano-1H-indene-2-carboxaldehyde, 

octahydro-5-methoxy-; CAS# 86803-90-9). See below 

Worksheet #3 for details.

 Worksheet#1: Identification of Acute Risk to Aquatic Organisms:

Acute Endpoint Value Factor Acute COC PEC Potential for Risk?

Fish LC50 0.376 ppm 5 76 ppb 0.11 ppb No

Daphnia LC50 0.150 ppm 5 30 ppb 0.11 ppb No

Algae EC50 0.432 ppm 4 108 ppb 0.11 ppb No

 Worksheet#2: Identification of Chronic Risk to Aquatic Organisms:

Chronic

Endpoint

Value Factor Chronic

COC

PEC Potential for Risk?

Fish ChV 0.019 ppm 10 2 ppb 0.0571 ppb No

Daphnia ChV 0.037 ppm 10 4 ppb 0.0571 ppb No

Algae ChV 0.289 ppm 10 29 ppb 0.0571 ppb No
13

 Worksheet #3: Identification of Non-Cancer Human Health Risk

Effect LOEL Type of 

Exposure Exposure MOE Potential for Risk?

Systemic 

effects 

[Read 

across to 

analog* 

CAS 86803-

90-9]

500

mg/kg/

day

Worker 

(cleaning 

drums)

0.414 mg/kg/day 

ChemSTEER ADD (dermal + 

inhalation, mainly dermal)

1208 Low concern*

Worker 

(unloading 

raw material 

from drums)

17.26 mg/kg/day 

ChemSTEER ADD (dermal + 

inhalation, mainly dermal)

29

Yes (without PPE);

Low concern (with 

proper PPE)*

Worker 

(sampling 

product)

0.086 mg/kg/day

ChemSTEER ADD (dermal + 

inhalation)

5814 Low concern

Worker 

(loading 

product into 

containers)

0.173 mg/kg/day 

ChemSTEER ADD (dermal + 

inhalation, mainly dermal)

2890 Low concern

General 

Population

0.206 mg/kg/day

E-FAST ADDpot (all routes) 2428 Low concern

*The exposure is mainly from dermal contact, which is a high-end estimate from the EPA/OPPT 2-Hand 

Dermal Contact with Liquid Model. Considering workers at both IFF and the drum collection contractor are 

required to wear chemical resistant gloves and other personal protective equipment (PPE), actual dermal 

exposure of the material is expected to be minimal, if any. Potential risk concern is expected to be low with 

proper PPE.
14

References

1) Determination of Physico-Chemical Properties of FRET 09-0536. IFF Test Substance FRET 09-

0536, IFF 2014. Study attached as ID# 007.

2) Ready Biodegradability Test of FRET 09-0536. IFF Test Substance FRET 09-0536, IFF 2014. 

Study attached as ID# 014.

3) Draft Report: Fish, Acute Toxicity Test for FRET 09-0536. IFF Test Substance FRET 09-0536, 

IFF 2014. Study attached as ID# 021.

4) Acute Toxicity in Daphnia magna. 1995. RIFM Location 30033, Sub-Reference 04/04.

5) Algae Inhibition Test. 1995. RIFM Location 30034, Sub-Reference 05/04.

6) Acute Dermal Toxicity Study in Rabbits. 1985. RIFM Location 30022, Sub-Reference 11/01.

7) Acute Oral Toxicity Study in Rats. 1989. RIFM Location 30021, Sub-Reference 11/22.

8) Repeated Insult Patch Test (RIPT) – Shelanski Method. IFF Test Substances FRET 09-0536-01

and FRET 09-0536-02, IFF 2014. Study attached as ID# 09.

9) Induction of Antioxidant-Response-Element Dependent Gene Activity And Cytotoxicity (Using 

MTT) in the Keratinocyte ARE-Reporter Cell Line Keratinosens. IFF Test Substance Research 

Fragrance Chemical TM 09-0536, IFF 2014. Study attached ID# 010.

10) Sensitization Screen Using the Direct Peptide Reactivity Assay (DPRA). IFF Test Substance 

TM09-0536, IFF 2014. Study attached ID# 011.

11) Evaluation of the Ability of FRET 09-0536 to Induce Chromosome Aberrations in Cultured 

Peripheral Human Lymphocytes (With Repeat Experiment). IFF Test Substance FRET 09-0536, 

IFF 2014. Study attached ID# 12.

12) Evaluation of the Mutagenic Activity of FRET 09-0536 in the Salmonella Typhimurium Reverse 

Mutation Assay and the Eschericia Coli Reverse Mutation Assay (With Independent Repeat). IFF 

Test Substance FRET 09-0536, IFF 2014. Study attached ID# 13.

13) 4-Week Oral (Gavage) Toxicity Study of Methoxy Dicyclopentadiene Carboxaldehyde in the Rat. 

1996. RIFM Location 30030, Sub-Reference 12/13.