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| Certificateof      Amalgamation           | Certificatde      fusion                                       |
|-------------------------------------------|----------------------------------------------------------------|
|                                      |                                                           |
| Canada      BusinessCorporations      Act | Loi      canadienne surles      sociétés par actions |

|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |   |                                                                                                                                                                                                                                                                                                                           |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Helix      BioPharma Corp.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |   | 316461-6                                                                                                                                                                                                                                                                                                                       |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |   |                                                                                                                                                                                                                                                                                                                           |
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|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |   |                                                                                                                                                                                                                                                                                                                           |
| Name      of corporation-Dénomination de la société                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |   | Corporation      number-Numéro de la société                                                                                                                                                                                                                                                                    |
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| I      hereby certify that the above-namedcorporation      resulted from an amalgamation,under      section 185 of the Canada Business Corporations      Act, of the corporations set out in the attached articles of      amalgamation.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |   | Je      certifie que la société susmentionnéeest      issue d’une fusion, en vertu del’article      185 de la Loi canadienne      sur les sociétés par actions, des sociétés dont les      dénominations apparaissent dans les statuts de fusion      ci-joints. |
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|     /s/                                                                                                                                                       Director      - Directeur |   |     July      31, 1995 / le 31 juillet 1995 Date      of Amalgamation - Date de fusion                                                                                                                                                                                                                |

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| Canada Business      Corporations      Act | Loi      canadienne sur lessociétés      par actions |   |   FORM      9ARTICLES      OF AMALGAMATION(SECTION      185) |   |   FORMULE      9STATUS      DE FUSION(ARTICLE      185) |
|--------------------------------------------|----------------------------------------------------------------|--------|-------------------------------------------------------------------|--------|--------------------------------------------------------------|
|                                       |                                                           |   |                                                              |   |                                                         |
|                                       |                                                           |   |                                                              |   |                                                         |
|                                       |                                                           |   |                                                              |   |                                                         |

| 1 —      Name of amalgamated corporationHelix      Biopharma Corp.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    | Dénomination      de la société issue de la fusion                                                     |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |
| 2 –      The place in Canada where the registered office is tobe      situatedVancouver,      British Columbia                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        | Lieu      au Canada où doit etre situé Ie siège social                                                 |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |
| 3 —      The classes and any maximum number of shares that thecorporation      is authorized to issue                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 | Catégories      et tout nombre maximal d'actions que la société est autorisée à      émettre |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |
| Common      voting      shares                                                                                       –  unlimitedPreferred      shares issuable in one or more      series                                              –  10,000,000 See      Schedule “A” which is incorporated into this form. |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |
| 4 —      Restrictions, if any, on share transfersNone                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 | Restrictions      sur le transfert des actions, s'il y a lieu                                                         |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |
| 5 —      Number (or minimum and maximum number) of directorsMinimum Six (6); Maximum Nine      (9)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    | Nombre      (ou nombre minimal et maximal) d'administrateurs                                                          |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |
| 6 —      Restrictions, if any, on business the corporation may carryonNone                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            | Limites      imposées à l'activité commerciale de la société, s'il y alieu                   |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |
| 7 —      Other provisions, if any                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     | Autres      dispositions, s'il y a lieu                                                                                    |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |
|   None                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |   |
| 8 —      The amalgamation has been approved pursuant to that section or subsection      of the Act which is indicated as follows:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |                                                                                                                       | 8  —   La      fusion a été approuvée en accord avec l'article ou leparagraphe dela Loi      indiqué ci-après |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |        x                                                                                                              | 183 |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |        r                                                                                                              | 184(1) |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |        r                                                                                                              | 184(2) |
| 9 — Name of the      amalgamating corporationsDénomination des sociétés      fusionnantes                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              | Corporation      No.No      de la société                                                                   | Signature | Date | TitleTitre |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |   |   |   |
| International      Helix Biotechnologies Inc.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               | 316462-4                                                                                                                   | /s/ Terry Owen | 1995-07-10 | President |
| Intercon      Pharma Inc.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   | 235911-1                                                                                                                   | /s/ Jerry McElroy | 1995-07-10 | President |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |   |   |   |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |                                                                                                                       |   |   |   |
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|                                                                                                                                                         |                                                       |
|--------------------------------------------------------------------------------------------------------------------------------------------------------------|------------------------------------------------------------|
| FOR      DEPARTMENTAL USE ONLY – A L’USAGE DU MINISTÈRE SEULEMENTCorporation      No. — No de      la société 316461-6 | Filed      — Déposée JUL      26 1995 |

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| (a) | an      unlimited number of common shares ("common shares"), the holders of which      are entitled: |
|-----|------------------------------------------------------------------------------------------------------|

|   | (i) | to      vote at all meetings of shareholders, except meetings at which only      holders of a specified class of shares are entitled to      vote; |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (ii) | subject      to the rights, privileges, restrictions and conditions attaching to any      other class or series of shares of the Corporation, to receive any      dividends declared and payable by the Corporation on the common shares;      and |
|--------|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (iii) | subject      to the rights, privileges, restrictions and conditions attaching to any      other class of shares of the Corporation, to receive the remaining      property of the Corporation upon dissolution;  and |
|--------|-------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (b) | 10,000,000      preferred shares ("preferred shares") which, as a class, have attached      thereto the following rights, privileges, restrictions and      conditions: |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (i) | preferred      shares may at any time and from time to time be issued in one or more      series. The directors may from time to time, by resolution passed before      the issue of any preferred shares of any particular series, fix the number      of preferred shares in, and determine the designation of the preferred      shares of, that series and create, define and attach special rights,      privileges, restrictions and conditions to the preferred shares of that      series, including, but without limiting the generality of the foregoing,      the voting rights, if any, attached to any preferred shares of any series,      the rate or amount of dividends, whether cumulative, non-cumulative or      partially cumulative, the dates, places and currencies of payment thereof,      the consideration for, and the terms and conditions of, any purchase for      cancellation or redemption thereof, including redemption after a fixed      term or at a premium, conversion or exchange rights, the terms and      conditions of any share purchase plan or sinking fund; PROVIDED HOWEVER      THAT no special right, privilege, restriction or condition so created,      defined or attached shall contravene tile provisions of sub-clause b (ii)      hereof; |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (ii) | the      preferred shares of each series shall, with respect to the payment of      dividends and the distribution of assets or return of capital, in the      event of liquidation, dissolution or winding-up of tile Corporation,      whether voluntary or involuntary, or any other return of capital or      distribution of the assets of the Corporation among its shareholders for      the purpose of winding up its affairs, rank on a parity with the preferred      shares of every other series and be entitled to preference over the common      shares and over any other shares of the Corporation ranking junior to the      preferred shares.  The preferred shares of any series may also      be given such other preferences, not inconsistent with these Articles,      over the common shares, and any other shares of the Corporation ranking      junior to such preferred shares as may be fixed in accordance with clause      (b) (i). |
|--------|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| Certificateof      Amendment              | Certificatde      modification                                 |
|-------------------------------------------|----------------------------------------------------------------|
|                                      |                                                           |
| Canada      BusinessCorporations      Act | Loi      canadienne surles      sociétés par actions |

|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |          |                                                                                                                                                                                                                                                                                                                                               |
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|---------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Helix      BioPharma Corp.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |          | 316461-6                                                                                                                                                                                                                                                                                                                                           |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |          |                                                                                                                                                                                                                                                                                                                                               |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |          |                                                                                                                                                                                                                                                                                                                                               |
| Name      of corporation-Dénomination de la société                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |          | Corporation      number-Numéro de la société                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |          |                                                                                                                                                                                                                                                                                                                                               |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |          |                                                                                                                                                                                                                                                                                                                                               |
| I      hereby certify that the articles of theabove-named      corporation were amended:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |          | Je      certifie que les statuts de la société susmentionnée ont été      modifiés:                                                                                                                                                                                                                                  |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |          |                                                                                                                                                                                                                                                                                                                                               |
| a)    under      section 13 of the Canada      Business Corporations     Act      in accordance      with      the attached notice;                                                                                                                                                                                                                                                                                                                                                                                                                   |        r | a)    en      vertu de l'article 13 de la Loi canadienne                   sur les sociétés par actions, conformément      à l'avis ci-joint;                                                                                                                           |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |          |                                                                                                                                                                                                                                                                                                                                               |
| b)     under      section 27 of the Canada    Business      Corporations Act as set out in the attached     articles of      amendment      designating a series of shares;                                                                                                                                                                                                                                                                                                                                                       |        r | b)    en      vertu de l'article 27 de la Loi canadienne sur                   les sociétés par actions, tel qu'il est      indiqué dans les clauses              modificatrices ci-jointes désignant une      série d'actions; |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |          |                                                                                                                                                                                                                                                                                                                                               |
| c)    under      section 179 of the Canada    Business      Corporations Act as set out in the     attached      articles of amendment;                                                                                                                                                                                                                                                                                                                                                                                                |        x | c)    en      vertu de l'article 179 de la Loi canadienne sur les      sociétés par             actions, tel qu'il est indiqué dans les clauses modificatrices      ci-jointes;                                                                                              |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |          |                                                                                                                                                                                                                                                                                                                                               |
| d)    under      section 191 of the Canada    Business      Corporations Act as set out in the     attached      articles of reorganization;                                                                                                                                                                                                                                                                                                                                                                                           |        r | d)    en      vertu de l'article 191 de la Loi canadienne sur les      sociétés par             actions, tel qu'il est indiqué dans les clauses de réorganisation      ci-jointes;                                                                                      |
|    /s/ Richard G.      Shaw                                                                                      Richard      G. ShawDirector      - Directeur |          |    January      21, 2000 / le 21 janvier 2000 Date      of Amendment - Date de modification                                                                                                                                                                                                                                    |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |          |                                                                                                                                                                                                                                                                                                                                               |

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|     Industry Canada                                                     | Industrie      Canada                                     | FORM      4ARTICLES      OF AMENDMENT(SECTIONS      27 OR 177) | FORMULE      4CLAUSES      MODIFICATRICES(ARTICLES      27 OU 177) |
|---------------------------------------------------------------------------------------------|----------------------------------------------------------------|----------------------------------------------------------------|--------------------------------------------------------------------|
|      Canada      Business          Corporations Act | Loi      canadienne sur lessociétés      par actions |

| 1.                               | Name      of Corporation - Dénomination de la société                                                                                                                                                                                                                                                                                                                                                                  | 2.             | Corporation      No. - No de la société                                           |
|----------------------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------------|---------------------------------------------------------------------------------------------|
|  HELIX      BIOPHARMA CORP. |                                                                                                                                                                                                                                                                                                                                                                                                                                  |  316461-6 |
|                             |                                                                                                                                                                                                                                                                                                                                                                                                                                  |           |                                                                                        |
|                             |                                                                                                                                                                                                                                                                                                                                                                                                                                  |           |                                                                                        |
|                             |                                                                                                                                                                                                                                                                                                                                                                                                                                  |           |                                                                                        |
|                             |                                                                                                                                                                                                                                                                                                                                                                                                                                  |           |                                                                                        |
| 3.                               | The      articles of the above-named corporation are amended as      follows::                                                                                                                                                                                                                                                                                                                                                        |           | Les      statuts de ia societe mentionnee ci-dessussont      modifies de la facon suivante: |
|                             |                                                                                                                                                                                                                                                                                                                                                                                                                                  |           |                                                                                        |
|                             |                                                                                                                                                                                                                                                                                                                                                                                                                                  |           |                                                                                        |
|                             | The      Articles of the above-named corporation are amended to reduce the minimum      number of directors from six (6) to five (5) such that the minimum number      of directors shall be five (5) and the maximum number of directors      shall be nine (9) Item      5 of the Articles, Number (or minimum and maximum number) of Directors,      shall read as follows: Minimum      Five (5), Maximum Nine (9) |

| DateJanuary      20, 2000 | Signature/s/ Nancy      Glaister                                                                               | Title      – TitreAssistant      Secretary |
|---------------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------------------------------------------------|

| FOR      DEPARTMENTAL USE ONLY  A L’USAGE DU MINISTERE      SEULEMENTCORPORATION      NO - No de la societe | FILED      - DEPOSEEJan      26 2000 |
|-----------------------------------------------------------------------------------------------------------------------------|--------------------------------------|

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| Certificateof      Amendment              | Certificatde      modification                                 |
|-------------------------------------------|----------------------------------------------------------------|
|                                      |                                                           |
| Canada      BusinessCorporations      Act | Loi      canadienne surles      sociétés par actions |

|                                                                                                                                                                                                                                                                                                                                                                                                                                                               |          |                                                                                                                                                                                                                                                                                         |
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|---------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Helix      BioPharma Corp.                                                                                                                                                                                                                                                                                                                                                                                                                                         |          | 316461-6                                                                                                                                                                                                                                                                                     |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                               |          |                                                                                                                                                                                                                                                                                         |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                               |          |                                                                                                                                                                                                                                                                                         |
| Name      of corporation-Dénomination de la société                                                                                                                                                                                                                                                                                                                                                                                                 |          | Corporation      number-Numéro de la société                                                                                                                                                                                                                                  |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                               |          |                                                                                                                                                                                                                                                                                         |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                               |          |                                                                                                                                                                                                                                                                                         |
| I      hereby certify that the articles of theabove-named      corporation were amended:                                                                                                                                                                                                                                                                                                                                                                           |          | Je      certifie que les statuts de la société susmentionnée ont été      modifiés:                                                                                                                                                                            |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                               |          |                                                                                                                                                                                                                                                                                         |
| a)    under      section 13 of the Canada Business Corporations Act in     accordance with      the attached      notice;                                                                                                                                                                                                                                                                                                  |        r | a)     en      vertu de l'article 13 de la Loi canadienne sur les sociétés      par    actions,      conformément à l'avis ci-joint;                                                                                             |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                               |          |                                                                                                                                                                                                                                                                                         |
| b)    under      section 27 of the Canada Business Corporations Act as     set out      in the attached articles      of amendment designating a series     of      shares;                                                                                                                                                                                                                  |        r | b)    en vertu de      l'article 27 de la Loi canadienne sur les sociétés par    actions, tel      qu'il est indiqué dans les clauses modificatrices ci-jointes désignant une          série d'actions; |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                               |          |                                                                                                                                                                                                                                                                                         |
| c)    under      section 179 of the Canada Business Corporations Act     as set      out in the attached      articles of amendment;                                                                                                                                                                                                                                                                                       |        x | c)    en vertu de      l'article 179 de la Loi canadienne sur les sociétés par actions, tel qu'il      est    indiqué dans les      clauses modificatrices ci-jointes;                                                           |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                               |          |                                                                                                                                                                                                                                                                                         |
| d)    under      section 191 of the Canada Business Corporations Act     as set      out in the attached      articles of reorganization;                                                                                                                                                                                                                                                                                  |        r | d)    en vertu de      l'article 191 de la Loi canadienne sur les sociétés par    actions, tel      qu'il est indiqué dans les clauses de réorganisation      ci-jointes;                                                             |
|    /s/ Richard      Shaw                                                             Richard      G. ShawDirector      - Directeur |          |    January      18, 2006 / le 18 janvier 2006 Date      of Amendment - Date de modification                                                                                                                                                                              |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                               |          |                                                                                                                                                                                                                                                                                         |

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|        Industry      Canada | Industrie      Canada                                          | ELECTRONIC      TRANSACTIONREPORT                   | RAPPORT      DE LA TRANSACTIONÉLECTRONIQUE      |
|-----------------------------------------------------------|----------------------------------------------------------------|-----------------------------------------------------|------------------------------------------------------|
| Canada      BusinessCorporations      Act                 | Loi      canadienne sur lessociétés      par actions | ARTICLES      OF AMENDMENT(SECTIONS      27 OR 177) | CLAUSES      MODIFICATRICES(ARTICLES      27 OU 177) |

| 1.                         | Name      of Corporation - Dénomination de la société                                                                                                                                                                                                                                                                                                                                                                                                                                    | 2.       | Corporation      No. - N° de la société |
|----------------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|--------------------------------------------------------|
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |     |
| Helix      BioPharma Corp. |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    | 316461-6 |
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |     |                                                   |
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |     |                                                   |
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |     |                                                   |
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |     |                                                   |
| 3.                         | The      articles of the above-named corporation are amended as      follows:Les      statuts de la société mentionnée ci-dessus sont modifiés de la façon      suivante:                                                                                                                                                                                                                                                                                                      |     |                                                   |
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |     |                                                   |
|                       | Item      7 of the Articles of Amalgamation of the Company shall read as      follows: “See      attached Schedule B.” There      be added to the Articles of Amalgamation a schedule, designated as      “Schedule B”, which shall read as follows:“The      directors may at any time appoint one additional director, who shall hold      office for a term not later than the first annual meeting of shareholders      held after January 17, 2006.” |

| Date2006-01-17 | Name      – NomKENNETH      A. CAWKELL | Signature | Capacity      of – en qualitéDIRECTOR |
|----------------|----------------------------------------------|-----------|--------------------------------------------------|

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| Certificateof      Amendment              | Certificatde      modification                                 |
|-------------------------------------------|----------------------------------------------------------------|
|                                      |                                                           |
| Canada      BusinessCorporations      Act | Loi      canadienne surles      sociétés par actions |

|                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |          |                                                                                                                                                                                                                                                                                                         |
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|---------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Helix      BioPharma Corp.                                                                                                                                                                                                                                                                                                                                                                                                                                            |          | 316461-6                                                                                                                                                                                                                                                                                                     |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |          |                                                                                                                                                                                                                                                                                                         |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |          |                                                                                                                                                                                                                                                                                                         |
| Name      of corporation-Dénomination de la société                                                                                                                                                                                                                                                                                                                                                                                                    |          | Corporation      number-Numéro de la société                                                                                                                                                                                                                                                  |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |          |                                                                                                                                                                                                                                                                                                         |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |          |                                                                                                                                                                                                                                                                                                         |
| I      hereby certify that the articles of the above-named corporation were      amended:                                                                                                                                                                                                                                                                                                                                                                             |          | Je      certifie que les statuts de la société susmentionnée ont été      modifiés:                                                                                                                                                                                            |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |          |                                                                                                                                                                                                                                                                                                         |
| a)    under      section 13 of the Canada Business Corporations Act in     accordance      with the      attached      notice;                                                                                                                                                                                                                                                                                                |        r | a)    en vertu de      l'article 13 de la Loi canadienne sur les sociétés par    actions,      conformément à l'avis ci-joint;                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |          |                                                                                                                                                                                                                                                                                                         |
| b)    under      section 27 of the Canada Business Corporations Act     as set      out in the attached      articles      of amendment designating a series     of      shares;                                                                                                                                                                                                                          |        r | b)    en vertu de      l'article 27 de la Loi canadienne sur les sociétés     par      actions, tel      qu'il est indiqué      dans les clauses modificatrices     ci-jointes      désignant une série d'actions; |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |          |                                                                                                                                                                                                                                                                                                         |
| c)    under      section 179 of the Canada Business Corporations Act     as set      out in the attached      articles of amendment;                                                                                                                                                                                                                                                                                          |        x | c)    en vertu de      l'article 179 de la Loi canadienne sur les sociétés     par      actions, tel qu'il est      indiqué dans les clauses modificatrices     ci-jointes;                                                       |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |          |                                                                                                                                                                                                                                                                                                         |
| d)    under      section 191 of the Canada Business Corporations Act     as set      out in the attached      articles of reorganization;                                                                                                                                                                                                                                                                                     |        r | d)    en vertu de      l'article 191 de la Loi canadienne sur les sociétés par actions,          tel      qu'il est indiqué      dans les clauses de réorganisation ci-jointes;                                                                       |
|    /s/      Richard G. Shaw                                                             Richard      G. ShawDirector      - Directeur |          |    February      1, 2007 / le 1 février 2007 Date      of Amendment - Date de modification                                                                                                                                                                                          |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |          |                                                                                                                                                                                                                                                                                                         |

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|        Industry      Canada                                                                       | Industrie      Canada                                          | ELECTRONIC      TRANSACTIONREPORT                   | RAPPORT      DE LA TRANSACTION ÉLECTRONIQUE     |
|---------------------------------------------------------------------------------------------------------------------------------|----------------------------------------------------------------|-----------------------------------------------------|------------------------------------------------------|
|              Canada Business             Corporations Act | Loi      canadienne sur lessociétés      par actions | ARTICLES      OF AMENDMENT(SECTIONS      27 OR 177) | CLAUSES      MODIFICATRICES(ARTICLES      27 OU 177) |

| 1.                         | Name      of Corporation - Dénomination de la société                                                                                                                                                                                                                                                                                                                                                                                                                                                       | 2.       | Corporation      No. - N° de la société |
|----------------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|--------------------------------------------------------|
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |     |
| Helix      BioPharma Corp. |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       | 316461-6 |
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |     |                                                   |
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |     |                                                   |
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |     |                                                   |
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |     |                                                   |
| 3.                         | The      articles of the above-named corporation are amended as      follows:Les      statuts de la société mentionnée ci-dessus sont modifiés de la façon      suivante:                                                                                                                                                                                                                                                                                                                         |     |                                                   |
|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |     |                                                   |
|                       | the      text set out in Schedule “B” to the Articles of Amalgamation be deleted      and replaced with the following: “The      directors may at any time appoint one or more additional directors, who      shall hold office for a term notlater      than the close of the next annual meeting of shareholders, but the total      number of directors so appointedmay      not exceed one third of the number of directors elected at the previous      annual meeting of shareholders.” |

| Date2007-02-01 | Name      – NomKENNETH      A. CAWKELL | Signature | Capacity      of – en qualitéDIRECTOR |
|----------------|----------------------------------------------|-----------|--------------------------------------------------|

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|               Certificate         of      Amalgamation | Certificatde      fusion                                       |
|---------------------------------------------------------------------------------------------------------------------------------------------|----------------------------------------------------------------|
|                                                                                                                                        |                                                           |
| Canada      BusinessCorporations      Act                                                                                                   | Loi      canadienne surles      sociétés par actions |

|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| HELIX      BIOPHARMA CORP.                                                                                                                                                                                                                                                                                                                                                                                                                                      |   | 447631-0                                                                                                                                                                                                                                                                                                    |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
| Name      of corporation-Dénomination de la société                                                                                                                                                                                                                                                                                                                                                                                              |   | Corporation      number-Numéro de la société                                                                                                                                                                                                                                                 |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
| I      hereby certify that the above-namedcorporation      resulted from an amalgamation,under      section 185 of the Canada Business Corporations      Act, of the corporations set out in the attached articles of      amalgamation.                                                                                                                                                                                                                   |   | Je      certifie que la société susmentionnée est issue d’une fusion, en vertu de      l’article 185 de la Loi      canadienne sur les sociétés par actions, des sociétés dont les      dénominations apparaissent dans les statuts de fusionci-joints. |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                            |   |                                                                                                                                                                                                                                                                                                        |
|   /s/ Richard G.      Shaw                                                             Richard      G. ShawDirector      - Directeur |   |   April      30, 2008 / le 30 avril 2008 Date      of Amalgamation - Date de fusion                                                                                                                                                                                                          |

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|           Canada      Business                Corporations Act | Loi      canadienne sur lessociétés      par actions |   |   FORM      9ARTICLES      OF AMALGAMATION(SECTION      185) |   |   FORMULE      9STATUS      DE FUSION(ARTICLE      185) |
|----------------------------------------------------------------------------------------------------------------------------------------------------------|----------------------------------------------------------------|--------|-------------------------------------------------------------------|--------|--------------------------------------------------------------|
|                                                                                                                                                     |

| 1 –      Name of the Amalgamated CorporationHELIX      BIOPHARMA CORP.                                                                                                                                                                                                                                                                                      | Dénomination      sociale de la société issue de la fusion                                             |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                                                                                                              |                                                                                                                       |
| 2 –      The province or territory in Canada where the registered office is to be      situatedBritish      Columbia – Colombie Britannique                                                                                                                                                                                                           | La      province ou le territoire au Canada où se situera le siège      social                              |
|                                                                                                                                                                                                                                                                                                                                                              |                                                                                                                       |
| 3 –      The classes and any maximum number of shares that thecorporation      is authorized to issue                                                                                                                                                                                                                                                       | Catégories      et tout nombre maximal d'actions que la société est autorisée à      émettre |
|                                                                                                                                                                                                                                                                                                                                                              |                                                                                                                       |
| Unlimited      Common Shares10,000,000      Preferred SharesThere      shall be attached to the Common and Preferred Shares, Special Rights      andRestrictions      set out in the attached Schedule A.                                                                                                                                                         |
|                                                                                                                                                                                                                                                                                                                                                              |                                                                                                                       |
| 4 –      Restrictions, if any, on share transfersNone                                                                                                                                                                                                                                                                                                       | Restrictions      sur le transfert des actions, s'il y a lieu                                                         |
|                                                                                                                                                                                                                                                                                                                                                              |                                                                                                                       |
| 5 –      Number (or minimum and maximum number) of directors Minimum      Five (5); Maximum Nine (9)                                                                                                                                                                                                                                                   | Nombre      (ou nombre minimal et maximal) d'administrateurs                                                          |
|                                                                                                                                                                                                                                                                                                                                                              |                                                                                                                       |
| 6 –      Restrictions, if any, on business the corporation may carryon None                                                                                                                                                                                                                                                                            | Limites      imposées à l'activité commerciale de la société, s'il y alieu                   |
|                                                                                                                                                                                                                                                                                                                                                              |                                                                                                                       |
| 7 –      Other provisions, if any                                                                                                                                                                                                                                                                                                                           | Autres      dispositions, s'il y a lieu                                                                                    |
|                                                                                                                                                                                                                                                                                                                                                              |                                                                                                                       |
| The      directors may at any time appoint one or more additional directors, who      shall hold office for a term not later than the close of the next annual      meeting of shareholders, but the total number of directors so appointed      may not exceed one third of the number of directors elected at the      previous annual meeting of shareholders. |
|                                                                                                                                                                                                                                                                                                                                                              |                                                                                                                       |   |
| 8 –      The amalgamation has been approved pursuant to that section or subsection      of the Act which is indicated as follows:                                                                                                                                                                                                                      |                                                                                                                       | La      fusion a été approuvée en accord avec l'article ou le paragraphe de la Loi      indiqué ci-après |
|                                                                                                                                                                                                                                                                                                                                                              |        r                                                                                                              | 183 |
|                                                                                                                                                                                                                                                                                                                                                              |        x                                                                                                              | 184(1) |
|                                                                                                                                                                                                                                                                                                                                                              |        r                                                                                                              | 184(2) |
| 9 –      Name of the amalgamating corporationsDénomination sociale des sociétés      fusionnantos                                                                                                                                                                                                                                            | Corporation      No.No      de la société                                                                   | Signature | Date | TitleTitre | Tel.      No.No      de tél. |
|                                                                                                                                                                                                                                                                                                                                                              |                                                                                                                       |   |   |   |   |
| Helix      Biopharma Corp.                                                                                                                                                                                                                                                                                                                                        | 3164616                                                                                                                    | /s/Kenneth A. Cawkell | 2008-04-28 | Secretary | 604-684-3323 |
| Helix      Product Development Inc.                                                                                                                                                                                                                                                                                                                               | 3810879                                                                                                                    | /s/Kenneth A. Cawkell | 2008-04-28 | Secretary | 604-684-3323 |
| 6933912      Canada Ltd.                                                                                                                                                                                                                                                                                                                                          | 6933912                                                                                                                    | /s/Kenneth A. Cawkell | 2008-04-28 | Secretary | 604-684-3323 |
| Sensium      Technologies Inc.                                                                                                                                                                                                                                                                                                                                    | 3481484                                                                                                                    | /s/Kenneth A. Cawkell | 2008-04-28 | Secretary | 604-684-3323 |
| 6965954      Canada Ltd.                                                                                                                                                                                                                                                                                                                                          | 6965954                                                                                                                    | /s/Kenneth A. Cawkell | 2008-04-28 | Secretary | 604-684-3323 |
|                                                                                                                                                                                                                                                                                                                                                              |                                                                                                                       |   |   |   |   |
| FOR      DEPARTMENTAL USE ONLY – A L’USAGE DU MINISTÈRESEULEMENT                                                                                                                                                                                                                                                                                 |
|                                                                                                                                                                                                                                                                                                                                                              |

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|   | a. | to      vote at all meetings of shareholders, except meetings at which only      holders of a specified class of shares are entitled to    vote; |
|--------|----|--------------------------------------------------------------------------------------------------------------------------------------------------|

|   | b. | subject      to the rights, privileges, restrictions and conditions attaching to any      other class or series of shares of the Corporation, to receive any      dividends declared and payable by the Corporation on the Common Shares;      and |
|--------|----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | c. | subject      to the rights, privileges, restrictions and conditions attaching to any      other class of shares of the Corporation, to receive the remaining      property of the Corporation upon dissolution;  and |
|--------|----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | a. | the      Preferred Shares may at any time and from time to time be issued in one or      more series.  The directors may from time to time, by resolution      passed before the issue of any preferred shares of any particular series,      fix the number of preferred shares in, and determine the designation of      the preferred shares of; that series and create, define and attach special      rights, privileges, restrictions and conditions to the preferred shares of      that series, including, but without limiting the generality of the      foregoing, the voting rights, if any, attached to the preferred shares of      any series, the rate or amount of dividends, whether cumulative,      non-cumulative or partially cumulative, the dates, places and currencies      of payment thereof, the consideration for, and the terms and conditions      of, any purchase for cancellation or redemption thereof; including      redemption after a fixed term or at a premium, conversion or exchange      rights, the terms and conditions of any share purchase plan or sinking      fund; PROVIDED HOWEVER THAT no special right, privilege, restriction or      condition so created, defined or attached shall contravene the provisions      of paragraph 2(b) herein; and |
|--------|----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | b. | the      Preferred Shares of each series shall, with respect to the payment of      dividends and the distribution of assets or return of capital, in the      event of liquidation, dissolution or winding-up of the Corporation,      whether voluntary or involuntary, ox any other return of capital or      distribution of the assets of the Corporation among its shareholders for      the purpose of winding up its affairs, rank on a parity with the preferred      shares of every other series and be entitled to preference over the common      shares and over any other shares of the Corporation ranking junior to the      Preferred Shares. The Preferred Shares of arty series may also be given      such other preferences, not inconsistent with these Articles, over the      Common Shares, and any other shares of the Corporation ranking junior to      such Preferred Shares as may be fixed in accordance with paragraph 2(a)      hereinbefore. |
|--------|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|