----

| BETWEEN      : | NATIONAL RESEARCH COUNCIL OF      CANADA, whose head office address is:1200      Montreal RoadOttawa,      Ontario KIA 0R6(through      its Institute, whose name and address are:Institute      for Biological Sciences 1200 Montreal Road, Building M-54 Ottawa, Ontario      K1A 0R6 | (called      “NRC”)(called      the “Institute”) |
|----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------------------------------------------------------------------------|

| AND      :  | HELIX      BIOPHARMA CORPORATIONa      corporation under the laws of Ontario, Canada whose head office address      is:3-305      Industrial Parkway South,Aurora      ON Canada L4G 6X7 | (called      the “Licensee”) |
|------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|------------------------------------------|

|   | (a) | NRC      owns or controls certain technology which is subject to intellectual      property rights, including without limitation inventions (which may be      protected by patents), copyright, trade secrets, know-how, and information      that is confidential. |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | NRC      and the Licensee desire to enter into a licence agreement that will permit      the technology to be used for commercial  purposes. |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------|

----

| 1.1   | “NRC Technology” means      the inventions (not necessarily patentable), trade secrets, know-how,      Software, designs, written works, samples, biological materials, and      technical information (confidential or not) relating to the “*** Antibody      patent application” (NRC case # ***) tentatively  entitled: |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 1.2   | “Licensee Technology’      means the inventions (not necessarily patentable), patent(s), trade      secrets, know-how, software, designs, written works, samples, biological      materials, and technical information (confidential or not) relating to      Helix Biopharma Proprietary Compound named “DOS47” and related compounds      as described by US application # 20040115186 including any improvements,      continuation, divisional applications derived from  it. |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.3   | “Foreground Technology”      means the inventions (not necessarily patentable), patent(s),      including any improvements, continuation, divisional applications derived      from such patent(s), trade secrets, know-how, software, designs, written      works, samples, biological materials, and technical information      (confidential or not) relating to novel molecules resulting from the      combination of the NRC Technology and the Licensee Technology. Such      Foreground Technology is proprietary toNRC. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.4   | “Patents” means the      following patents and patent applications, plus any divisions,      continuations, continuations-in-part, re-issues, and extensions of these      patents and patent applications plus any other patents and patent      applications in countries within the Territory, covering essentially the      same inventions or claiming priority of patenting rights from any other      patent application within the Patententitled: |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.5   | “NRC Intellectual      Property Rights” means Patents and other exclusionary rights in respect of      the NRC Technology, and rights in respect of Confidential information      included in the NRC Technology. |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.6   | “NRC’s Internal Purposes”      means research and development within NRC’s laboratories and the      provision of services to NRC’s customers, conducted in such a way as to      avoid the disclosure of either confidential information of the Licensee or      confidential information of NRC which is deliverable under this Agreement      and whose disclosure would deprive the Licensee of some significant      advantage intended by thisAgreement. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.7   | “Licensee’s Internal      Purposes” means research and development within Licensee’s      laboratories conducted in such a way as to avoid the disclosure of      Confidential information of NRC whose disclosure would deprive NRC of some      significant advantage intended by this  Agreement. |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.8   | “Product” means any      thing (including equipment, system, device, component, chemical, molecule,      database, or software) that incorporates or embodies or is derived from      any part of the Foreground Technology (including all modifications made by      the Licensee or NRC), or that results from practicing or using the      Foreground Technology, and also any document that relates to the      Foreground Technology. |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.9   | Service” means any      service to third parties, not provided free, that is provided by using any      part of the Foreground Technology (including all modifications made by the      Licensee or NRC), or by using a Product, or that relates to a Product,      including (without limiting the generality of the foregoing)      customization, maintenance, installation, training, consulting, testing,      operating, dissemination of advertising or publicity, production,      packaging and distribution. |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 1.10   | “Sale” means every      disposition of a Product, including selling, renting, leasing, licensing,      lending, and bartering of a Product.  It also means every      instance of providing Service. It is considered to occur when a Product or      Service is delivered or an invoice is issued, whichever occurs first. A      Sale exists irrespective of the collection of any debt (regardless of any      accounting principle), but not if money received is refunded. “Sell”, and      “Sold” have corresponding meanings. |
|------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.11   | “Sales Revenue” means      the gross price billed by the Licensee or sub-licensee to a purchaser on      account of every Sale of a Product or Service, including recurring and      deferred payments when received, less the following      deductions: |
|------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (a)   | rebates      granted and taken, except rebates granted wholly or partially in      consideration of a third party’s agreement to purchase anything that is      not a Product or Service as defined in this  Agreement; |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (b)   | trade,      promotional, quantity or cash discounts actually allowed and taken, not      exceeding amounts that are customary in the  trade; |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------|

| (c)   | amounts      repaid or credited by reason of rejections or returns of Products, or as      retroactive price reductions; |
|-----------------|--------------------------------------------------------------------------------------------------------------------------|

| (d)   | custom      duties, excise taxes, sales taxes, value-added taxes and any compulsory      payments made to government authorities, if separately stated on an      invoice with the intention that costs incurred by the Licensee will be      recovered from the invoiced person,and |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (e)   | actual      shipping and insurance costs in transporting Products to third parties if      separately stated on an invoice with the intention that costs incurred by      the Licensee will be recovered from the invoiced  person. |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.12   | “Other Revenue” means      all payments, and the value of other consideration, which the Licensee      receives in relation to sub-licences, other than royalties from Sales of      Products or Services by the sub-licensee.  This includes,      without limitation, initial fees, milestone payments, bonuses, periodic      fees, fees for consulting, fees for upgrades, dividends, and the value of      equity. |
|------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.13   | “Reporting Date(s)” is      (are) the date(s) in every year up to which royalties since the last      Reporting Date are calculated as follows: January 31 and July      31. |
|------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 1.14   | “Affiliate” is a      corporation of which more than 20% of the voting shares are owned by the      Licensee, or which owns more than 20% of the voting shares of the      Licensee, or of which more than 50% of the voting shares are owned by      another Affiliate or if it owns more than 50% of another      Affiliate. |
|------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.15   | “Arm’s length” has the      meaning as used for purposes of the Income Tax Act of      Canada, and is not limited to the same meaning as being an      Affiliate. |
|------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.16   | “Territory means      worldwide. |
|------------------|----------------------------------------|

| 2.0   | GRANT OF      LICENCE |
|-----------------|-----------------------|

| 2.1   | Grant:  NRC      grants to the Licensee a licence of NRC’s Intellectual Property Rights and      the Patents, for the Licensee’s Internal Purposes.  NRC also      grants to the Licensee a licence of the Foreground Technology effective      throughout the Territory: |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (a)   | to      reproduce, make, use, import and Sell any Product and export any Product      to any place within the Territory; |
|-----------------|--------------------------------------------------------------------------------------------------------------------------|

| (b)   | to      engage contractors to reproduce or make any Product to be used or sold by      the Licensee; |
|-----------------|------------------------------------------------------------------------------------------------------|

| (c)   | to      Sell any Service. |
|-----------------|---------------------------|

| 2.2   | Field of      Use:  The Licensee shall not deaf in any manner with      Product, Services or Foreground Technology except as authorized under this      Agreement for applications within the Territory and within the authorized      field of use, which is: therapeutic and diagnostic applications for      humans. |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.3   | Exclusivity:  The      rights granted to the Licensee by way of licence under this Agreement      are: |
|-----------------|------------------------------------------------------------------------------------------------------------------|

| (a)   | non-exclusive,      for Licensee’s Internal Purposes, with respect to NRC Technology and the      Patents; |
|-----------------|------------------------------------------------------------------------------------------------------------------|

| (b)   | exclusive,      with respect to Foreground Technology and to any patent relying on      Foreground Technology. |
|-----------------|----------------------------------------------------------------------------------------------------------------|

| 2.4   | Sub-licensing:  The      Licensee may sub-license the rights granted by this Agreement with respect      to Foreground Technology to: |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------------|

| (a)   | purchasers      of a Product, as needed to permit normal use of a Product by an end- user      and such sub-licences survive termination of this    Agreement; |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (b)   | any      other person, on terms approved by NRC in writing in    advance. |
|-----------------|---------------------------------------------------------------------------|

| 2.5   | Canadian      Content:  The Licensee shall perform all manufacturing of      Products in Canada, and shall use Canadian-made materials in Products to      the extent that they are reasonably available.  Canadian-based      sub-licensees shall be subject to the same      requirement.  Foreign-based sub-licensees are not so restricted,      but they shall not be permitted to sell Products that will be imported      into Canada. |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.6   | Delivery:  NRC      shall give the Licensee a copy of all of NRC’s  relevant: |
|-----------------|-----------------------------------------------------------------------------------------------|

| (a)   | Patents,      including the latest draft of any applications that have not matured into      patents; |
|-----------------|-------------------------------------------------------------------------------------------------------|

| (b)   | documentation      that is reasonably necessary for an understanding of the NRC Technology,      to the extent that it exists; |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------|

| (c)   | samples,      in reasonable quantities, of materials illustrating the NRC      Technology. |
|-----------------|--------------------------------------------------------------------------------------------|

----

| 3.0   | FEES AND      ROYALTIES |
|-----------------|-------------------------|

| 3.1   | Licence      Fee:  As consideration for the grant of the licence,      immediately upon receiving a fully signed original of this Agreement the      Licensee shall pay NRC the sum of *** plus applicable    taxes. |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.2   | Licensee’s      Royalty:  The Licensee shall pay to NRC royalties for all      Sales of Products and Services as follows: *** of Sales      Revenue. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.3   | Milestone      payments: |
|-----------------|--------------------------|

|   | – | A      milestone payment of twenty five thousand dollars (CAN $25,000) upon      successful completion of Phase I clinical trials as confirmed by a      regulatory authority (e.g.: United States Food and Drug      Administration). |
|--------|---------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | – | A      milestone payment of fifty thousand dollars (CAN $50,000) upon successful      completion of Phase Ilb clinical trials as confirmed by a regulatory      authority. |
|--------|---------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | – | A      milestone payment of one hundred and twenty five thousand dollars (CAN      $125,000) upon successful completion of Phase Ill clinical trials as      confirmed by a regulatoryauthority. |
|--------|---------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | – | A      milestone payment of two hundred thousand dollars (CAN $200,000) upon      receipt of market approval by a regulatory  authority. |
|--------|---------|------------------------------------------------------------------------------------------------------------------------------------------|

|   | – | A      milestone payment of two hundred thousand dollars (CAN $200,000) upon      receipt of market approval by a regulatory  authority. |
|--------|---------|------------------------------------------------------------------------------------------------------------------------------------------|

| 3.4   | Royalty for Unauthorized      Sales:  Without implying any waiver of NRC’s rights to      enforce limitations in this Agreement or to seek damages for breach of      this Agreement, the Licensee shall pay to NRC, without further demand by      NRC, royalties on Sales of Products or Services which are not authorized      with respect to Territory or Field ofUse. |
|-----------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.5   | Other      Revenue:  The Licensee shall pay to NRC *** of Other      Revenue. |
|-----------------|-----------------------------------------------------------------------------------------|

| 3.6   | Minimum Annual      Royalty:  The Licensee shall pay NRC a Minimum Annual      Royalty (“MAR”) according to the following schedule (with tax to be      added), regardless of whether |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 3.7   | Sub-Licensee’s      Royalty:  the Licensee shall be responsible for paying      NRC the same royalties that would be payable if Sales by the sub-licensee      were Sales by the Licensee. |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (a)   | Licensee      shall require the sub-licensee to pay directly to NRC royalties for all      Sales of Products and Services by the sub-licence royalties as if Sales of      Products and Services by the sub-licensee were Sales of Products and      Services by the Licensee; |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (b)   | Licensee      guarantees the payments required from the  sub-licensee. |
|-----------------|------------------------------------------------------------------------|

| 3.8   | Tax:  The      Goods and Services Tax, or Harmonized Sales Tax, or Quebec Sales Tax, is      applicable to payments required by this Agreement, depending on the      residence of the Licensee or sub-licensee, while none of those taxes      normally applies to foreign-based payers. It is the responsibility of the      payer, whether Licensee or sub-licensee, to determine tax status and to      pay the applicable tax.  NRC’s GST and HST registration number      is 121 491 807.  NRC’s QST registration number is 1006 178      088. |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.9   | Interest:  In      lieu of the regulation that requires NRC to charge interest on overdue      amounts at a rate based on variable central-bank rates, interest at one      percent (1%) per month compounded monthly (annual rate of 12.68%) must be      paid on overdue amounts from the date when payment is due until the date      it is received by NRC.  NRC may revise that rate upon two (2)      months’ notice. An administrative charge of $25 will be invoiced for any      cheque, which is refused payment by the financial institution on which it      is drawn. |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.10   | Delinquent      Accounts:  NRC may use a collection agency to collect any      debt arising under this Agreement, and NRC may obtain a set-off of the      debt against any other money payable by the Government of Canada to the      Licensee.  The costs and fees of collection agencies shall be      added to the debt payable to NRC. |
|------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.11   | Statements:  The      Licensee must deliver royalty statements to NRC within sixty (60) days      after each Reporting Date, even if no Products or Services were      Sold.  NRC may provide a form for royalty statements, which the      Licensee must use.  Royalty statements must be certified      accurate and correct by the Chief Financial Officer or some other senior      officer of the Licensee, and must include the following information for      the period up to the Reporting Date or since the last Reporting      Date: |
|------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (a)   | the      quantity of Products made by or for the  Licensee; |
|-----------------|-------------------------------------------------------------|

| (b)   | the      quantity, and the Sales Revenue, for Products Sold at Arm’s      Length; |
|-----------------|-----------------------------------------------------------------------------------------|

| (c)   | the      quantity of Products disposed of at other than Arm’s Length or by barter,      the persons to whom disposed, and the basis for the    royalties; |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (d)   | Sales      Revenue from Services Sold; |
|-----------------|----------------------------------------|

| (e)   | a      calculation of the royalties due toNRC; |
|-----------------|------------------------------------------------|

| (f)   | a      projection of Sales of Products and Services for the periods to be covered      in the next two royalty statements; |
|-----------------|----------------------------------------------------------------------------------------------------------------------------|

| (g)   | where      applicable, identical information as in (a) to (f) from the      sub-licensee. |
|-----------------|-------------------------------------------------------------------------------------------|

----

| 3.12   | Currency      Translation:  Sales Revenue and Other Revenue, and any      fixed payment to NRC required by this Agreement, when required to be      converted to Canadian dollars, shall be converted using the Bank of Canada      monthly exchange rate for the last month of the reporting      period.  This currency information is available at the Bank of      Canada website:      http://bank-banque-canada.ca/english/xrate/htm.  If payments to      NRC are required to be made in U.S. dollars, the conversion shall be the      rate of exchange in a major financial market, as published (errors      excluded) in a widely distributed Canadian or U.S. newspaper on the last      date of the reporting period, or within the seven preceding      days.  The basis of all conversions shall be stated in the      royalty statement submitted to NRC, accompanied by a printed copy of the      published basis of that conversion. |
|------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.13   | Remittances:  Royalty      statements must be accompanied by a remittance of the royalties due, in      Canadian or U.S. funds payable at par at Ottawa, Ontario, Canada.      Remittances can be made either by a bank transfer to an account which NRC      will designate if asked, or by a cheque payable to: “Receiver General -      National Research Council”, indicating on the cheque the reference number      (if any) appearing on the first page of this  Agreement. |
|------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | - NRC -      Accounts Receivable, at the NRC head office address stated above      (on page 1); |
|--------|-------------------------------------------------------------------------------------------------|

|   | - NRC -      Intellectual Property Services, at the NRC head office address      stated above (on page 1); |
|--------|------------------------------------------------------------------------------------------------------------|

|   | - the Institute,      at its address stated above (on page1). |
|--------|---------------------------------------------------------------|

| 3.14   | Records:  The      Licensee shall, and shall require sub-licensees  to: |
|------------------|-----------------------------------------------------------------------------------|

| (a)   | keep      accurate, detailed and complete records in accordance with generally      accepted accounting principles, at its expense, which shall be retained      and available at its principal place of business in respect of Products      and Services, and the basis of any Other Revenue which may require a      payment to NRC; |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (b)   | provide      NRC, upon request and without charge, with annual Financial Statements      (prepared by an external auditor, if available) that will verify the Sales      Revenue derived from Products andServices; |
|-----------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (c)   | keep      all the records intact for a period of not less than three (3)      years. |
|-----------------|--------------------------------------------------------------------------------------|

| 3.15   | NRC’s      Audits:  The Licensee shall make all relevant records      available at its premises during normal business hours, upon reasonable      notice, and permit NRC and its authorized representatives to audit,      inspect, and copy the records.  In such circumstances, the      Licensee shall afford all facilities and collaboration to NRC and its      authorized representatives, and furnish all information necessary to the      understanding of the records.  If NRC’s audit reveals that      payments made by the Licensee are less than eight-tenths (80%) of the      amount that should have been paid, the Licensee shall reimburse NRC’s cost      of the audit which becomes a debt due immediately to NRC, along with a      debt of the shortfall in royalties and share of Other Revenue with      interest from the date on which the payments should have been      made.  If the Licensee presents obstacles to the audit, such      that a Chartered Accountant makes an affidavit that the audit is      impossible or impractical, the Licensee shall be deemed by this clause to      have agreed that NRC may estimate a fair value of the royalties and share      of Other Revenue payable, based on the best information available, and the      Licensee shall pay that amount to NRC immediately together with interest      from the date on which the payments should have been  made. |
|------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 3.16   | Licensee’s      Audits:  At its option, NRC shall be entitled to an audit      of Other Revenue and of the Sales Revenue from the Sale of Products and      Services as part of the Licensee’s regular audit, at no cost to      NRC.  When NRC gives reasonable advance notice of requiring that      audit, the Licensee will provide NRC with an audited statement prepared by      an external auditor that will verify Other Revenue and the Sales Revenue      derived from the Sales of Products and Services in any year for which an      audit has not been completed at the time NRC gives notice.  If      the audit reveals a shortfall in what was paid to NRC, the Licensee shall      pay the shortfall amount to NRC immediately, with interest from the date      on which the payments should have been made.  If the audit      reveals that payments made by the Licensee are not less than eight-tenths      (80%) of the amount that should have been paid, NRC shall reimburse the      Licensee for any incremental costs of the additional part of the      audit. |
|------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.17   | Continuing      Rights:  The rights granted in the preceding three (3)      paragraphs shall survive the termination of this Agreement for a period of      three (3) years. |
|------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.18   | Allocation To      Technology:  If requested, the Licensee shall cooperate      with NRC in providing information about a reasonable allocation of the      Licensee’s Sales Revenue and Other Revenue, and therefore of royalties,      amongst the various elements of the Products or Services, which is      information that NRC requires for allocating shares of royalties amongst      the creators pursuant to NRC’s AwardsPolicy. |
|------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 4.0   | INTELLECTUAL      PROPERTY |
|-----------------|----------------------------|

| 4.1   | Patenting      Responsibility:  NRC shall bear the responsibility and      pay the cost to obtain and maintain Patents in the countries that NRC      chooses to file an application directly or through the national phase of a      PCT application.  NRC shall use reasonable efforts to obtain      those Patents and shall not allow those Patents to lapse for failure to      comply with maintenance obligations.  If applications (including      the national phase of a PCT application) could be filed in countries,      which NRC has not chosen, they may be requested by the Licensee and shall      be filed by NRC if the Licensee bears all expenses including without      limitation the cost of maintaining those  Patents. |
|-----------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 4.2   | Sharing Patent      Costs:  The Licensee shall reimburse NRC, promptly on the      receipt of an invoice for twenty five per cent (25%) of NRC’s internal      costs (to the extent reasonable) and disbursements related to obtaining      and maintaining the Patents.  This includes costs and      disbursements incurred before this Agreement was in  effect. |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5.0   | TECHNICAL      ASSISTANCE |
|-----------------|---------------------------|

| 5.1   | No      Assistance:  NRC is not obliged to provide the Licensee      with technical assistance relating to the NRC Technology or the      Product.  NRC may, at its sole discretion, supply technical      assistance under separate contracts, in accordance with NRC’s customary      terms and standard rates. |
|-----------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5.2   | NRC’s      Improvements:  In the event that NRC produces additions      or changes to the NRC Technology or to the Foreground Technology, which by      their nature could not be used without some use of the NRC Technology or      the Foreground Technology, NRC shall inform the Licensee and, the      additions or changes shall be regarded as part of the NRC Technology or      the Foreground Technology for all purposes of this    Agreement. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 5.3   | Licensee’s Improvements or      Additions:  In the event that the Licensee produces      additions or changes to the NRC Technology or the Foreground Technology,      which by their nature could not be made or used without some use of the      NRC Technology or the Foreground Technology, the Licensee shall provide      NRC, within ninety (90) days from the time the additions or changes have      been made, with all available technical information concerning them,      including source code if software is involved, and shall be deemed to      license NRC to use them for NRC’s Internal Research Purposes at no cost to      NRC. |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5.4   | Grant      Back:  Upon Termination of this Agreement, the Licensee      shall be deemed to have granted to NRC, and shall execute any documents      reasonably required by NRC as additional evidence of this, a      non-exclusive, unconditional, irrevocable, perpetual royalty- free      licence, including the right to sub-license, to make, use or sell articles      incorporating any additions and changes made by the Licensee which were      required by the preceding paragraph to be reported to NRC, whether      patentable or unpatentable, without any obligation to account to the      Licensee. |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6.0   | CONFIDENTIALITY |
|-----------------|-----------------|

| 6.1   | What      is Confidential:  The NRC Technology and the Foreground      Technology are confidential to NRC except for published elements and      elements which NRC states in writing to be not confidential. Software      source code is confidential to NRC.  The Licensee’s derivative      software is confidential to the Licensee, unless the Licensee states      otherwise in writing. Any documents of either party, marked      ‘Confidential”, “Protected’’, “Proprietary”, or similar words, are      confidential to that party. |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6.2   | Obligations of      Confidentiality:  Except to the extent expressly      authorized in this Agreement, each party shall, until five years after the      expiration date defined in paragraph 11.1, protect the other party’s      confidential information with some degree of care as it uses to protect      its own confidential information, but not less than a reasonable degree of      care, and shall not use such information for purposes other than those      contemplated by this Agreement.  Disclosure of information by a      receiving party is permitted to the extent that it can be proved to      be: |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (a)   | independently      developed by the receiving party without reference to or use of the      confidential information of the otherparty; |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------|

| (b)   | received      from the third party without breach of any obligation of      confidentiality; |
|-----------------|----------------------------------------------------------------------------------------------|

| (c)   | in      the public domain at the time of its disclosure or that later becomes      publicly available without breach of this  Agreement; |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------|

| (d)   | required      to be disclosed by law, including in the case of NRC, the Access to Information Act,      provided that the receiving first provides the disclosing party      with notice of such requirements and of its intent to disclose the      information; or |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (e)   | required      in order to comply with applicable rules and regulations of any stock      exchange on which the Licensee’s shares are  listed. |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------|

| 6.3   | If Confidentiality      Lost:  This Agreement remains in effect regardless of any      loss of confidentiality of the NRC Technology or the Foreground Technology      at any time for      any reason, although each party retains the right to terminate this      Agreement for a breach by the otherparty. |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 7.0   | DILIGENT      EXPLOITATION |
|-----------------|----------------------------|

| 7.1   | Requiring      Diligence:  The licence granted by this Agreement is      conditional upon diligent exploitation of the rights granted to the      Licensee, in a manner likely to satisfy the demand for the Products and      Services in relation to all reasonable applications, and to adequately      serve the Licensee’s customers, throughout the Territory.  If      NRC suspects a lack of diligence, NRC will give written notice to the      Licensee, inviting the Licensee to explain to the satisfaction of NRC, in      writing within six (6) months, why the level of exploitation should be      considered satisfactory. Diligence will be judged without regard to      royalties or minimum royalties paid.  NRC reserves the right to      find a lack of diligence after the six-months’ notice and after having      studied any response made by the Licensee, and this decision shall be      conclusive, subject only to the dispute resolution provisions of this      Agreement. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 7.2   | Consequences of Lack of      Diligence:  On a country-by-country basis, or in all      countries at the same time, when NRC finds a lack of diligence in      accordance with the preceding paragraph, NRC has the right    to: |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (a)   | convert      any exclusivity to non-exclusivity in acountry, |
|-----------------|--------------------------------------------------------------|

| (b)   | terminate      the licence entirely in respect of a country,or |
|-----------------|----------------------------------------------------------------|

| (c)   | modify      the field of use. |
|-----------------|-------------------------------|

| 7.3   | Multiple      Occurrences:  The procedure for challenging diligence,      and the consequences, may be invoked more than  once. |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------|

| 8.0   | USE OF NRC’S      NAME |
|-----------------|------------------------------|

| 8.1   | Control of      Use:  NRC reserves the right, in its sole discretion, to      control any unauthorized use of its name and may notify the Licensee that      it must immediately cease using the name, including any abbreviations,      words, or images that imply an association with NRC.  Upon      receipt of such notification, the Licensee must use its best efforts to      withdraw from circulation any written material that represents an      unauthorized use. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 8.2   | Authorized      Use:  Notwithstanding any other provision of this      Agreement, NRC hereby authorizes the Licensee, and the Licensee agrees to      take all reasonable opportunities, such as in sales literature or press      releases, to acknowledge NRC as the source of the NRC Technology, but not      so as to imply, in any such acknowledgment, that NRC endorses or approves      any Product or Service offered for Sale by the  Licensee. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.0   | WARRANTIFS,      DISCLAIMERS AND INDEMNITIES |
|-----------------|----------------------------------------------|

| 9.1   | Warranty of Licensing      Rights:  NRC warrants that it has not previously granted      any rights that would conflict with the rights granted by this      Agreement.  NRC warrants that it is either the owner or the      licensee (with power to sub-license) of Patents licensed by this      Agreement. |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.2   | No Implied      Warranties:  Except for representations, warranties or      conditions expressly made in this Agreement, the NRC Technology and the      Foreground Technology are supplied and licensed on an as is” basis, and      there are no representations, warranties or conditions, express or implied      by statute, including without limitation any with respect    to: |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| (b)   | operational      state, character, quality, or freedom from  defects; |
|-----------------|-----------------------------------------------------------------------|

| (c)   | non-infringement      of rights of third parties under present or future  patents. |
|-----------------|------------------------------------------------------------------------------------|

| 9.3   | No Contestation of      Validity:  The Licensee acknowledges the validity of the      Patents and copyright licensed hereunder and agrees not to contest such      validity during the life of this Agreement, either directly or indirectly      by assisting other parties.  This clause is not operational      under U.S. law. |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.4   | Limited      Damages:  NRC shall not be liable, in any event, for      consequential or incidental damages, or loss of income, arising from the      possession or use of anything licensed or conveyed pursuant to this      Agreement. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.5   | Indemnity:  NRC      rejects all liability and responsibility relating to the consequences of      using the Products or providing Services.  The Licensee shall      indemnify and save harmless NRC, its employees and agents from and      against, and be responsible for: |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (a)   | all      claims, demands, losses, damages, costs including solicitor and client      costs, actions, suits or proceedings brought by any third party, that are      in any manner based upon, arising out of, related to, occasioned by, or      attributable to: |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (b)   | the      manufacturing, distribution, shipment, offering for Sale, Sale, or use of      Products, Services or the Foreground Technology;  and |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------|

| (c)   | product      liability and infringement of intellectual property rights other than      copyright; |
|-----------------|----------------------------------------------------------------------------------------------------|

| (d)   | other      costs, including extra-judicial costs, of NRC defending any such action or      proceeding, which NRC shall have the right to defend with counsel of its      choice. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.0   | INFRINGFMENT      LITIGATION |
|------------------|------------------------------|

| 10.1   | Initial      Consultation:  If the Licensee receives or become aware      of any claim or assertion by a third party that any activities by the      Licensee under this Agreement constitute an infringement or other      violation of a third party’s patents or other intellectual property, the      Licensee shall notify NRC and shall provide NRC with all details relating      to the allegation.  The parties shall promptly enter into      discussions with the third party to determine the extent and validity of      the infringement and the parties mutually agreed course of action. Each      party will absorb its own costs of the  discussions. |
|------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.2   | Negotiation:  The      parties may negotiate with a third party to obtain any additional rights      required, such as may arise if a third party’s patent      emerges.  Each party will absorb its own costs of      negotiation.  If those additional rights require payment, the      parties will negotiate for a reduction in royalties payable to NRC, and      failing agreement within sixty (60) days, either party may invoke the      arbitration procedure in this Agreement to settle the amount of the      reduction of the royalty. |
|------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.3   | Legal      Action:  The parties may agree to jointly defend or      pursue litigation, but neither party shall bind or commit the other party      to any course of action which involves liability for legal costs, expenses      or damages.  If the parties fail to agree, within a reasonable      time having regard to the normal progress of litigation, as to any course      of action which might be jointly taken, either party may take or defend      proceedings alone, if legally entitled to act alone, and shall be entitled      to retain any amount awarded to it by a court, or paid to it as a      settlement by the third party, and the excess of that amount over costs |
|------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 10.4   | Damages for      Infringement:  If the parties (and not with one party      participating only as a formality) have jointly pursued an infringer by      litigation and the Licensee obtains money from the infringer as a      settlement or by court order, the excess of that money above the      Licensee’s costs that were reasonably incurred for the settlement or      litigation, shall be regarded as Other Revenue in relation to a      sub-licence. |
|------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 11.0   | DURATION AND      TERMINATION |
|------------------|-------------------------------|

| 11.1   | Expiration:  This      Agreement shall become effective when it has been signed by both parties.      Unless terminated earlier, this Agreement shall terminate when the last      patent right related to the Foreground Technology expires, on a      country-by-country basis. |
|------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 11.2   | Termination by Either Party for      Default or Breach:  In the event that one party defaults      or breaches any of the provisions of this agreement, the other party shall      have the right to terminate this Agreement by giving written notice to the      defaulting party, but this act shall not prejudice the right of NRC to      recover any fee due at the time of such termination and shall not      prejudice any cause of action or claim of NRC accrued or to accrue on      account of any breach or default by the Licensee.  However, if      the defaulting party cures the breach within sixty (60) days after the      notice is given, this Agreement shall continue in full force and      effect. |
|------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 11.3   | Termination by      NRC:  This Agreement, at the option of NRC, may be      terminated forthwith by NRC if the Licensee becomes bankrupt, or      insolvent, or has a receiver appointed to continue its operations, or      passes a resolution for winding up, or takes the benefit of any statute      relating to bankrupt or insolvent debtors or the orderly payment of      debts. |
|------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 11.4   | Procedure on      Termination:  Upon termination the Licensee      shall: |
|------------------|-------------------------------------------------------------------------------------|

| (a)   | deliver      a detailed statement to NRC of the inventory of all Products then existing      and not Sold by the Licensee as at thatdate; |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------|

| (b)   | retain      the right to Sell Products then existing and shall pay royalties (but not      MAR) to NRC as Products are Sold for a period of one year provided that      any remaining inventory of Products shall be destroyed by the License at      the end of that year; |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (c)   | retain      the right to deliver Services for which a contractual commitment has been      made before the Termination, for a period of one year, subject to the      continued obligation to pay Royalties on the Sales Revenue for those      services; and |
|-----------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (d)   | cease      any other use of the NRC Technology and the Foreground Technology unless      the NRC Technology and the Foreground Technology, in total, has then      become part of the public domain other than through any act or omission      of the      Licensee. |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 11.5   | Accrued      Obligations:  Termination does not release a party from      any obligations, which accrued while this Agreement was in force or upon      its termination. |
|------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 12.0   | LAW AND      DISPUTES |
|------------------|-----------------------|

| 12.1   | Choice of      Law:  This Agreement shall be interpreted according to      the laws of the Province of Ontario and the laws of Canada in force      there. |
|------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 12.2   | Courts:  Any      litigation concerning this Agreement, including litigation arising from      arbitration, shall be brought only in a court which has ordinary      jurisdiction over the defendant on the basis of residence, and the      residence of NRC for this purpose shall be regarded as the location of the      Institute. |
|------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 12.3   | Dispute      Resolution:  Both parties will use reasonable efforts to      reach an amicable negotiated settlement of any dispute concerning the      interpretation or operation of this Agreement.  Disputes      concerning this Agreement shall not be litigated.  If      negotiation fails to resolve a dispute within sixty (60) days, either      party can require non-binding mediation, whereupon the parties shall      jointly appoint one impartial expert mediator to mediate according to      mutually agreed procedures.  If a party refuses to effectively      participate in mediation, or if mediation continues for more than sixty      (60) days, either party can require binding arbitration under the Commercial Arbitration Act      of Canada, whereupon the parties shall attempt to jointly appoint      one impartial expert arbitrator.  If the parties cannot agree      within thirty (30) days on the choice of an arbitrator, each party shall      appoint its own arbitrator and those arbitrators shall jointly appoint a      chairperson of an arbitral tribunal.  An arbitral award shall      not include punitive damages, or interim measures.  Each party      shall pay its own costs and an equal share of all other costs of mediation      and arbitration, except for the exceptional circumstance in which an      arbitral award may require the payment of all costs by a party who has      brought a plainly frivolous dispute.  Unless otherwise agreed by      the parties when the occasion arises, mediation and arbitration shall be      held in the city where the Institute is located.  This provision      survives the Termination of thisAgreement. |
|------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 13.0   | GENERAL TERMS AND      CONDITIONS |
|------------------|-----------------------------------|

| 13.1   | Entire      Agreement:  This Agreement represents the entire      understanding between the parties as of the effective date hereof, and      supersedes all prior communications, negotiations and agreements, written      or oral, concerning the NRC Technology and the Foreground      Technology. |
|------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 13.2   | Limits of      Agreement:  For greater certainty, the parties agree that      this is not an assignment of ownership of copyright or of patent rights,      but merely a licence.  This Agreement shall not be construed as      creating the relationship of principal and agent, employer and employee,      partnership, or joint venture. |
|------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 13.3   | Amendments: This      Agreement may only be amended by an agreement in writing, signed by the      parties, expressly referring to thisAgreement. |
|------------------|---------------------------------------------------------------------------------------------------------------------------------------------------|

| 13.4   | Severance:  If      any provision in this Agreement is found, by a court or arbitration, to be      wholly or partly invalid, illegal or unenforceable in any respect, the      remainder of this Agreement shall remain enforceable and this Agreement      shall be construed as if that provision had never existed.  The      request to initial each page is not a condition of this      Agreement. |
|------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 13.5   | Waiver:  Failure      by either party to assert rights arising from any breach or default of      this Agreement, or acceptance of payments, shall not be regarded as a      waiver of rights.  No failure to assert rights, no waiver, and      no toleration implies any continuing or future waiver of      rights. |
|------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 13.6   | Assignment:  This      Agreement is personal to the parties, so that neither its assignment, nor      its assumption by a corporation formed by amalgamation with a party is      valid without the other party’s writtenconsent. |
|------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 13.7   | Force      Majeure:  Neither party shall be responsible or liable to      the other for failure or delay in the performance of this Agreement due to      war, fire, accident or other casualty, labour disturbance, act of the      public enemy, act of God, or any other contingency beyond that party’s      reasonable control.  In the event of applicability of this      paragraph, the party affected by such force majeure shall use its best      efforts to eliminate, cure and overcome any such causes and resume      performance of its obligations as soon as  possible. |
|------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 13.8   | Notices:  Any      notice contemplated by this Agreement, unless a different address is      subsequently notified by one Party to the other in writing, must be sent      to the address stated at the beginning of this Agreement where the Parties      are identified, by: |
|------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (a)   | registered      mail, and then it is deemed to be an effective notice five (5) days after      it is sent, |
|-----------------|------------------------------------------------------------------------------------------------------------|

| (b)   | courier,      and then it is an effective notice only when acknowledged by an official      receipt, or |
|-----------------|---------------------------------------------------------------------------------------------------------|

| (c)   | by      personal delivery to the office of the chief executive officer of the      Party, and then it is an effective notice only when acknowledged by a      signature of either that person or a person with apparent authority to      receive messages. |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| SIGNED by the Licensee      in duplicate at                    Aurora,      Canada               ,      Canada:                                                                                                                                                                                                                                                                                 |
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             | HELIX      BIOPHARMA CORPORATION |
| Date       April 27,      2005                                                                                                                                                                                                            | Per:  /s/ Donald      Segal                                                                      |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
|                              Name and title: Donald      Segal, President                                                                                                                                                                                                                                                                                                                       |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| SIGNED by NRC in      duplicate at Ottawa, Canada:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             | NATIONAL      RESEARCH COUNCIL OF CANADA |
| Date       April 28,      2005                                                                                                                                                                                                       | Per: /s/ Dr. Gabrielle      Adams                                                                      |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
|                                    Name and title: Dr.      Gabrielle Adams                                           Director General NRC-Institute for Biological  Sciences |