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| AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  | 1.  CONTRACT ID CODE | PAGE OF PAGES |
| 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   | 2 |
| 2.  AMENDMENT/MODIFICATION NO.0016                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  | 3.  EFFECTIVE DATESee Block 16C | 4.  REQUISITION/PURCHASE REQ. NO.N/A. | 5.  PROJECT NO. (If applicable) |
| 6.  ISSUED BY CODE                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  | ASPR-BARDA | 7.  ADMINISTERED BY (If other than Item 6)CODE | ASPR-BARDA |
| ASPR-BARDA200 Independence Ave., S.W.Room 640-GWashington DC  20201                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 | ASPR-BARDA200 Independence Ave., S.W.Room 638-GWashington DC  20201 |
| 8.  NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        | (X) | 9A.  AMENDMENT OF SOLICITATION NO. |
| ACHAOGEN, INC. 1361331ACHAOGEN, INC.            7000 SHORELINE7000 SHORELINE CT STE 371SOUTH SAN FRANCISCO CA  940801957                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |
| 9B.  DATED (SEE ITEM 11)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
| X                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   | 10A.  MODIFICATION OF CONTRACT/ORDER NO.HHSO100201000046C |
| CODE 1361331                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        | FACILITY CODE | 10B.  DATED (SEE ITEM 13)09/01/2010 |
| 11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |
| o                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   | The above numbered solicitation is amended as set forth in Item 14.  The hour and date specified for receipt of Offers |  o is extended | o is not extended |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:  (a) By completingItems 8 and 15, and returning _______________ copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) Byseparate letter or telegram which includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED ATTHE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If byvirtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makesreference to the solicitation and this amendment, and is received prior to the opening hour and date specified. |
| 12.  ACCOUNTING AND APPROPRIATION DATA (If required)N/A.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
| 13.  THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS.  IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |
| CHECK ONE                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           | A.THIS CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A. |
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| X                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   | B.THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date. etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b). |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | C.THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF: |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                | D.OTHER (Specify type of modification and authority) |
| E.  IMPORTANT:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      | Contractor |  x is not | o is required to sign this document and return      0      copies to the issuing office. |
| 14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)Tax ID Number:  68-0533693DUNS Number:  167293153A.The purpose of this modification is to incorporate the following changes into the contract:1.Article G.5., Invoice/Financing Request and Contract Financial Reporting is hereby modified to add the following:6)In addition to the Contracting Officer, the Contractor shall submit electronic copies of the invoices to the Contracting Officer’s Representative (COR) and to the Program Support Center (PSC) at PSC_Invoices@psc.hhs.gov.Continued... |
| Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
| 15A.  NAME AND TITLE OF SIGNER (Type or print)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      | 16A.  NAME AND TITLE OF CONTRACTING OFFICER (Type or print)ETHAN J. MUELLER |
| 15B.  CONTRACTOR/OFFEROR                                        (Signature of person authorized to sign)                                                                                                                                                                                                                                                                                                                                                    | 15C.  DATE SIGNED | 16B.  UNITED STATES OF AMERICA/s/ Ethan J. Mueller(Signature of Contracting Officer) | 16C.  DATE SIGNED7/10/14 |
| NSN 7540-01-152-8070Previous edition unusable                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |   | STANDARD FORM 30 (REV. 10-83)Prescribed by GSAFAR (48 CFR) 53.243 |

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| CONTINUATION SHEET                                  | REFERENCE NO. OF DOCUMENT BEING CONTINUEDHHSO100201000046C/0016 | PAGE      OF |
| 2                                                   | 2 |
| NAME OF OFFEROR OR CONTRACTORACHAOGEN, INC. 1361331 |
| ITEM NO.(A)                                         | SUPPLIES/SERVICES(B) | QUANTITY(C) | UNIT(D) | UNIT PRICE(E) | AMOUNT(F) |