# Support Documents for Significant New Use Rule (SNUR) on Premanufacture Notice (PMN)

P-11-580

EPA Docket EPA-HQ-OPPT-2011-0942

# Index A-001 Structure Activity Team (SAT) Report for PMN P-11-580 A-002 Initial Review Engineering Report for PMN P-11-580 A-003 Initial Review Exposure Report for PMN P-11-580

# A-001 Structure Activity Team (SAT) Report

for PMN P-11-580

## SAT Report PMN Number: P-11-0580 SAT Date: 8/23/2011 Print Date: 10/3/2011

Related cases : Health related cases:

Concern levels : 

### Type of Concern: Health Eco Comments Level of Concern: 1-2 3

Persistence Bioaccum Toxicity Comments 1 21

Exposure Based Review : Health: N o Ecotox: N o
Routes of exposure : Health: Dermal Inhalation Ecotox: All releases to water Fate: ; Keywords : Keywords: IRR-E,MM,L, N EURO, AQUATOX-A,C
Summary of Assessment :

Fate : Fate Summary: P-11-0580 FATE: Liquid with MP < 25 C (E) log Kow = 5.61 (E); S = 2.4 mg/L at 25 C (E) VP = 0.022 torr at 25 C (E, N OMO5) BP = 259 C ( N OMO5) based on 135-140 C @ 14 mm(M) H = 2.08E-4 (E) log Koc = 2.95 (E) log Fish BCF = 3.37 (E) log Fish BAF = 3.75 (E)

### POTW removal (%) = 90 via sorption Time for complete ultimate aerobic biodeg = wk-mo Sorption to soils/sediments = strong Volatilization half-life from a standard river = 6 hrs Volatilization half-life from a standard lake = 8 da Atmospheric Oxidation Half-life = 5 hr via OH radical PBT Potential: P1B2 *CEB FATE: Migration to ground water = negl

Health : Health Summary: Absorption is moderate all routes based on p hysical/chemical properties. There is concern for irritation to the eyes, lungs, and mucous membranes and concern for solvent neurotoxicity. Low moderate concern.

Ecotox :

Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 0.11 or * daphnid 48-h LC50 0.083 or * green algal 96-h EC50 0.10 fish

_ chronic value 0.015 daphnid

_ chronic value 0.021 algal

_ chronic value 0.14 Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value

_ Ecotox Values Comments: Predictions are based on SARs for neutral organic chemicals; SAR chemical class = alcohol; MW 226; log Kow = 5.61 (EPI); liquid with mp = unknown (P); S = 2.4 mg/L at 25 C (P); p H7; effective concentrations based on 100% active ingredients and nominal concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 2

SARs neutral organic chemiicals SAR Class alcohol new chemicals category: neutral organics

Ecotox Factors Comments:

SAT Chair: Becky Jones

# A-002 Initial Review Engineering Report

for PMN P-11-580p110580.eng INITIAL REVIEW ENGINEERING REPORT PMN: 11-0580 Focus Ready Draft 9/1/2011 ENGINEER: Austin \ AH PV (kg/yr): 25,000 Import Only

SUBMITTER: Eastman Kodak Co USE: Chemical intermediate for a coupler for imaging products. Synthetic sequence: P-11-578 -> P-11-0579 + P-11-580 -> P-11-581 -> P-11-582 -> P-11-583 (ER, P-03-628).

OTHER USES:

MSDS: Yes Label: No Gen Eqpt: Safety glasses with side shields (or goggles), impervious gloves and protective clothing Respirator: NIOSH-approved with an APF of 1,000 Health Effects: Causes eye irritation. May be harmful if inhaled, absorbed through skin, or swallowed. High vapor concentrations may cause drowsiness and irritation of the eyes or respiratory tract. TLV/PEL: Not established.

CRSS : Chemical Name: Cyclohexanol, 2,6-bis(1,1-dimethylethyl)-4-methylS-H20: 0.0024 g/L @ VP: 2.2E-2 torr @ MW: 226.00 %<500 %<1000 Physical State and Misc CRSS Info: Neat: Liquid Mfg: Liquid Proc/Form: NA End Use: Destroyed. Submitted Data: Liquid; WS = 0.007 g/L (Sub.Est.). A particle size of 15.22 microns is provided, but this appears to be in error, since the substance is a liquid. Literature Data (STN eProp): BP = 135-140°C at 14 torr. Estimated Data (NOMO5 with BP entered as 135°C at 14 torr): BP = 258.9°C at 760 torr; VP = 0.022 torr. Estimated Data (EPI with MP = 20°C): WS = 0.00235 g/L; log P = 5.61; BP = 277.06°C; VP = 0.000552 torr. Estimated Data (STN/ACD Labs): WS = 0.0059 g/L; log P = 5. 437; BP = 269.9°C; VP = 0.0009.37 torr.

Consumer Use: No SAT (concerns) (08/23/2011): Migration to groundwater: Negligible PBT rating: P1B2T1 Health: 1-2 Dermal, Inhalation Eco: 3 Water (All releases to water with a CC = 2ppb)

OCCUPATIONAL EXPOSURE RATING: 2A Page 1p110580.eng
NOTES & KEY ASSUMPTIONS: Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS: None.

EXPOSURE-BASED REVIEW: No

INITIAL REVIEW ENGINEERING REPORT PMN: 11-0580

Use: Number of Sites/ Location: 1 Eastman Business Park Rochester NY 14652 Days/yr: 42

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same medium.
Air Typical: 8.0E-5 kg/site-day over 42 days/yr from 1 site Worst Case: 1.6E-4 kg/site-day over 42 days/yr from 1 site

Air Output 2: 2.6E-6 kg/site-day over 42 days/yr from 1 site Page 2p110580.eng

Incineration Output 2: 5.2E+1 kg/site-day over 42 days/yr from 1 site or 2.2E+3 kg/yr

Landfill High End: 1.8E+1 kg/site-day over 42 days/yr from 1 site or 7.5E+2 kg/yr

RELEASE TOTAL 2.9E+3 kg/yr - all sites

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY Tot. # of workers exposed via assessed routes: 3

Inhalation: Exposure to Vapor (Class II) Typical: 3.8E-2 mg/day over 42 days/yr Worst Case: 2.3E+0 mg/day over 42 days/yr Number of workers (all sites) with inhalation exposure: 3

Dermal: Exposure to Liquid at 100.00% concentration High End: 1.8E+3 mg/day over 42 days/yr Number of workers (all sites) with dermal exposure: 3 Page 3p110580.eng

Page 4

# A-003 Initial Review Exposure Report

for PMN P-11-580

### Page 1 of 1

POST FOCUS EXPOSURE REPORT Release information for this compound does not meet criteria for preparation of an exposure assessment; were eliminated and the were be low the threshold for exposure assessment

Assessor:

ENVIRONMENTAL RELEASES

Scenario#: Number of Release Sites: Release Activity:

Release Description: WATER LANDFILL INCINER LAND/INCIN FUGITIVE

Total Releases:
(kg/yr) (kg/yr) (kg/yr) (kg/yr) (kg/yr)
Release Days/yr:

Per Site Release:
(kg/day) (kg/yr) (kg/yr) (kg/yr) (kg/day)

Remarks: EAB DROP: Release information for this compound does not meet criteria for preparation of an exposure assessment in the Exposure Assessment Branch = s (EAB) Initial Review Exposure Report (this report).