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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF

CHEMICAL SAFETY AND

POLLUTION PREVENTION

MEMORANDUM

Date: 31-JUL-2013

Subject: Prometryn: Acute and Chronic Dietary (Food and Drinking Water) Exposure and 

Risk Assessment to Support the Section 3 Registration Request For Use of Prometryn 

on Snap Beans and Dill.

PC Code: 080805 DP Barcode: D408528

Decision No.: 467531 Registration No: 100-620 

Petition No.: 2E8052 Regulatory Action: Amended Sec. 3

Risk Assessment Type: Dietary Case No.: 0467

TXR No.: NA CAS No.: 7287-19-6

MRID No.: None 40 CFR: §180.222

From: Sarah J. Levy, Chemist

Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P)

Through: William Cutchin, Chemist

Ideliz Negron-Encarnacion, Ph.D., Chemist

Dietary Exposure Science Advisory Council (DESAC)/HED (7509P)

and

George F. Kramer, Ph.D., Branch Senior Scientist

RAB1/HED (7509P)

To: Kelly M. Lowe, Risk Assessor

RAB1/HED (7509P)

and

Barbara Madden, RM 05

Registration Division (RD; 7505P)

Executive Summary

Acute and chronic (food and drinking water) dietary-exposure and risk assessments were 

conducted using the Dietary Exposure Evaluation Model software with the Food Commodity

Intake Database (DEEM-FCID) Version 3.16, which uses food consumption data from the U.S. 

Department of Agriculture’s National Health and Nutrition Examination Survey, What We Eat in 

America, (NHANES/WWEIA) from 2003 through 2008. The analyses were performed to 
Prometryn Dietary Exposure and Risk Assessment DP# 408528

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support Section 3 use requests on snap beans and dill. It should be noted that prometryn is 

already registered for use on dill; however, the current registration is limited to a regional 

registration. The Registrant has submitted additional data to expand the regional registration to a 

national registration. The proposed national use pattern is identical to the currently registered 

regional use pattern. 

These analyses have been reviewed by two peer reviewers of the DESAC, per the DESAC 

Standard Operating Procedure (SOP) 2012.1.

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization 

The acute analysis assumed 100% crop treated (CT), tolerance-level residues for all foods, and 

DEEM 7.81 default processing factors. Dietary risk estimates were determined considering 

exposures from food plus drinking water using estimated drinking water concentrations 

(EDWCs) for surface water sources provided by the Environmental Fate and Effects Division 

(EFED). An acute EDWC value was generated using the carrot use pattern as this use yielded 

the highest acute EDWC value, 377.4 ppb. The acute assessment shows that the acute dietary

risk estimate is not of concern to HED [i.e., <100% acute population-adjusted dose (aPAD)]. 

The resulting acute dietary (food + drinking water) risk estimates utilized 17% of the aPAD for 

the females 13-49 years old population subgroup, the only acute population subgroup of concern 

for this assessment. 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

The chronic analysis assumed 100% crop treated (CT), tolerance-level residues for all foods, and 

DEEM 7.81 default processing factors. Dietary risk estimates were determined considering 

exposures from food plus drinking water using EDWCs for surface water sources provided by 

EFED. A chronic EDWC value was generated using the carrot use pattern as this use yielded the 

highest chronic EDWC value, 157.9 ppb. The assessment shows that the chronic dietary risk 

estimates are not of concern to HED [i.e., <100% chronic population-adjusted dose (cPAD)]. 

The resulting chronic dietary (food + drinking water) risk estimates utilized 8.6% of the cPAD 

for the general U.S. population and 23% of the cPAD for all infants (<1 year old), the most 

highly exposed population subgroup. 

Cancer 

A cancer dietary assessment was not conducted because prometryn is classified as “Group E: 

Evidence of non-carcinogenicity for humans.”

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: 
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http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG1999).

The most recent dietary risk assessment for prometryn was conducted on 08-AUG-2009 (Memo, 

W. Wassell; D367832).

II. Residue Information

Prometryn is a substituted thiomethy triazine herbicide (Group 5) registered in the U.S. for the 

control of weeds in a number of commodities. The Product and Residue Chemistry Chapters for 

the Prometryn RED were issued 08-DEC-1994. 

Residues of Concern: HED previously determined that the residue of concern in plants consists 

of the parent, prometryn per se, which is the currently regulated residue. HED concluded that if 

other major uses were registered in the future, additional metabolism studies would be required. 

The petitioner recently submitted a metabolism study in rice which was reviewed as part of the 

following memorandum: S. Levy, 13-MAR-2013; D398563. Although the rice metabolism 

study was deemed adequate, it presents a qualitatively different metabolic profile than the celery

and cotton profiles (Memo, C. Swartz, 05-DEC-1994; D208880 and 09-DEC-1995; D207139, 

respectively). In the celery and cotton metabolism studies, parent was the major residue and in 

the rice metabolism study metabolite GS-17794 was the major residue. Therefore, HED is still 

requesting a root crop metabolism study. This deficiency remains outstanding. Depending on 

results of the root crop metabolism study, additional field trial data could be required.

The nature of the residue in livestock is adequately understood based on acceptable poultry and 

ruminant metabolism studies. The residue of concern (and that which should be regulated) in 

livestock is the parent, prometryn per se. As in plants, the metabolism of prometryn in livestock 

involves N-dealkylation along with hydrolysis and/or amino acid conjugation. The 1994 Residue 

Chemistry Chapter concluded that residues of prometryn per se in meat and milk can be 

classified under Category 3 of 40 CFR §180.6(a). That is, there is no reasonable expectation of 

finite residues in meat and milk. No tolerances were required in the Residue Chapter; therefore, 

livestock feeding studies were not required. In the current petition, the only livestock feedstuff is 

cowpea, forage which may contribute up to 20% in dairy cow diets only. In the previously 

constructed dietary burden, barley forage was included in the dairy cattle diet. The established 

barley forage tolerance of 0.30 ppm is higher than the HED-recommended tolerance of 0.09 ppm 

associated with this petition; therefore, constructing a new dietary burden would result in a lower 

dietary burden. Pending submission of an additional plant metabolism study, HED tentatively 

concludes that the Category 3 situation remains valid for this registration request. 

For drinking water, EFED included parent only, as was done in previous risk assessments. 

Modeling parent only is a high-end, conservative assumption. EFED stated that their entire 

drinking water assessment for prometryn will be updated concurrent with registration review.

Established Tolerances: Permanent tolerances for residues of prometryn per se are currently

established in/on a variety of crops (40 CFR §180.222(a)). There is also a tolerance with 

regional registration in/on dill as well as tolerances for indirect or inadvertent residues in/on hay, 

straw, and forage of barley, oat, rye, triticale, and wheat.
Prometryn Dietary Exposure and Risk Assessment DP# 408528

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Recommended Tolerances: Based on the residue chemistry data submitted with the current 

petition, HED recommended for establishment of the tolerances outlined below. Furthermore, in 

accordance with the most recent guidance concerning tolerance expressions, HED recommends 

that the tolerance expression for 40 CFR §180.222 be changed as indicated below.

“(a) General. Tolerances are established for residues of the herbicide prometryn, including its metabolites and 

degradates, in or on the commodities in the table below. Compliance with the tolerance levels specified below is to 

be determined by measuring only prometryn [2,4-bis(isopropylamino)-6-methylthio-s-triazine] in or on the 

following raw agricultural commodities:”

Snap, bean, succulent.............................................................................0.05 ppm

Dillweed, fresh leaves............................................................................0.30 ppm

Dill, dried leaves....................................................................................1.1 ppm

and

(d) Indirect or inadvertent residues. Tolerances are established for indirect or inadvertent residues of the herbicide 

prometryn, including its metabolites and degradates, in or on the commodities in the table below. Compliance with 

the tolerance levels specified below is to be determined by measuring only prometryn ([2,4-bis(isopropylamino)-6-

methylthio-s-triazine] in or on the following raw agricultural commodities:”

Note that concurrent with the establishment of the HED-recommended tolerances for residues 

in/on dillweed, fresh leaves and dill, dried leaves, the established tolerance of 0.3 ppm in/on dill 

with regional restriction should be removed in 40 CFR §180.222(c).

 

Residue Data Used for Acute and Chronic Assessments: These analyses utilized established and 

HED-recommended tolerance-level residues for all commodities and DEEM (ver. 7.81) default 

processing factors.

III. Percent Crop Treated

Both the acute and chronic assessments utilized 100% CT for all commodities. 

IV. Drinking Water Data

Drinking water residues were incorporated directly into the acute and chronic dietary analyses 

(“water, direct, all sources” and “water, indirect, all sources”) and were provided by EFED 

(Memo, M. Ruhman, 13-MAR-2013; D403977). The EDWCs were screening-level estimates 

generated with the Food Quality Protection Act (FQPA) Index Reservoir Screening Tool 

(FIRST) in surface water and with Screening Concentration in Ground Water (SCI-GROW) for 

ground water. The driver for the EDWCs, for surface and ground water, was application to 

(previously registered use) carrots (three ground applications at 2 lbs a.i/A, 30 days apart).

Table 1. Maximum Screening EDWCs of Prometryn for Current and Proposed Uses.

Drinking Water Source (model) Use (Maximum Annual 

Rate)

Upper-Bound Estimated Drinking 

Water Concentrations (ppb)

Acute (peak 

exposure)

Chronic (annual 

mean exposure)

Surface Water (FIRST) Carrots (3 applications at 2 

lb ai/A, 30 days apart) 377.4 157.9

Groundwater (SCI-GROW) Carrots (3 applications at 2 

lb ai/A, 30 days apart) 23.4
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Surface water EDWCs of 0.3774 ppm and 0.1579 ppm were used in the acute and chronic 

analyses, respectively, as these values were the highest and provided a more conservative 

approach.

IV. DEEM-FCID Program and Consumption Information

Prometryn acute and chronic dietary exposure assessments were conducted using DEEM-FCID, 

Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEIA from 

2003 through 2008. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

V. Toxicological Information

Table 2 summarizes the toxicological doses and endpoints for prometryn concerning dietary

exposure assessment. The endpoints have been reviewed by the risk assessment team and are 

considered appropriate for the current risk assessment. 
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Table 2. Summary of Toxicological Doses and Endpoints for Prometryn for Use in Dietary Human-Health 

Risk Assessments. 

Exposure Scenario Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, LOC for 

Risk Assessment

Study and Relevant 

Toxicological Effects

Acute Dietary

(Females 13-49 years 

of age)

NOAEL = 12

mg/kg/day

UFA = 10X

UFH = 10X

UFFQPA = 1X 

aRfD = aPAD = 0.12

mg/kg/day

Developmental toxicity (rabbit)

LOAEL = 72 mg/kg based on 

increased incidence of 

resporptions, abortions, and postimplantation loss leading to 

decreased number of viable litters 

and live fetuses.

Chronic Dietary 

(All Populations)

NOAEL = 3.75

mg/kg/day

UFA = 10X

UFH = 10X

UFFQPA = 1X

cRfD = cPAD = 0.04

mg/kg/day

Chronic toxicity (dog; dietary)

LOAEL = 37.5 mg/kg/day based 

on degenerative hepatic changes, 

renal tubule degeneration, and 

bone marrow atrophy.

Cancer (Oral, 

Dermal, Inhalation)

Classification: “Group E: Evidence of non-carcinogenicity for humans.”

Abbreviations: UF = uncertainty factor, UFA = extrapolation from animal to human (interspecies), UFH = potential variation in sensitivity among 

members of the human population (intraspecies), UFFQPA = FQPA Safety Factor, NOAEL = no-observed adverse-effect level, LOAEL = lowestobserved adverse-effect level, RfD = reference dose (a = acute, c = chronic), PAD = population-adjusted dose, LOC = level of concern.

VI. Results/Discussion

For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the 

PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and 

various population subgroups. The results reported in Table 3 are for the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50-99 years. 

Results of Acute and Chronic Dietary Exposure Analyses

The resulting acute food plus drinking water risk estimates are not of concern to HED (<100% 

aPAD) at the 95th percentile of the exposure. The resulting acute risk estimate is 17% of the 

aPAD of the exposure distribution for females 13 to 49 years old, the only acute population 

subgroup of concern for this assessment.

The resulting chronic exposure estimates are not of concern to HED. The most highly exposed 

population was all infants (<1 year old) utilizing 23% of the cPAD (see Table 3 below for a 

summary of the results). A chronic cancer dietary assessment was not conducted since it was 

determined that prometryn is not a possible human carcinogen.
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Table 3. Summary of Dietary (Food + Drinking Water) Exposure and Risk for Prometryn.

Population Subgroup1

Acute Dietary2

(95th Percentile) Chronic Dietary Cancer

Dietary

Exposure 

(mg/kg/day)

% aPAD

Dietary 

Exposure

(mg/kg/day)

% cPAD

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population -- -- 0.003426 8.6

N/A N/A

All Infants (<1 year old) -- -- 0.009081 23

Children 1-2 years old -- -- 0.005136 13

Children 3-5 years old -- -- 0.004274 11

Children 6-12 years old -- -- 0.003041 7.6

Youth 13-19 years old -- -- 0.002484 6.2

Adults 20-49 years old -- -- 0.003390 8.5

Adults 50-99 years old -- -- 0.003366 8.4

Females 13-49 years old 0.020659 17 0.003377 8.4

1

 The values for the highest exposed population for each type of risk assessment is bolded.

2

 An acute dietary endpoint (aPAD = 0.12 mg/kg/day) was only determined for females 13-49 years old (see Table 

2).

The acute and chronic analyses assumed tolerance-level residues, 100% CT, and DEEM (ver. 

7.81) default processing factors. These analyses are considered very conservative and could be 

refined using anticipated-residue estimates (ARs), percent market share data, and/or empirical 

processing factors. However, at this time refinement is not necessary.

VIII. Conclusions

The acute and chronic dietary exposure and risk assessments were conducted using DEEMFCID, Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEIA 

from 2003 through 2008. 

An acute dietary risk analyses was conducted for females 13-49 years old only; an acute

endpoint of concern attributable to a single dose was not identified for the general U.S. 

population. The acute analysis assumed tolerance-level residues, 100% CT, and DEEM (ver. 

7.81) default processing factors. The acute analysis also incorporated drinking water estimates 

provided by EFED. The resulting acute food plus drinking water risk estimates for females 13-

49 years old are not of concern to HED (<100% aPAD) at the 95th percentile of the exposure 

distribution for females 13-49 years old. The resulting acute risk estimate is 17% of the aPAD at 

the 95th percentile of the exposure distribution for females 13-49 years old.

The chronic analysis assumed tolerance-level residues, 100% CT, DEEM (ver. 7.81) default 

processing factors, as well as drinking water estimates provided by EFED. The resulting chronic 

risk estimates are not of concern to HED. The most highly exposed population was all infants 

(<1 year old) utilizing 23% of the cPAD.

Attachments

Attachment 1: DEEM-FCID Acute Food + Drinking Water Residue Input File.

Attachment 2: DEEM-FCID Acute Exposure Estimates for Females 13-49 Years Old.

Attachment 3: DEEM-FCID Chronic Food + Drinking Water Residue Input File.

Attachment 4: DEEM-FCID Chronic Exposure Estimates.
Prometryn Dietary Exposure and Risk Assessment DP# 408528

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cc: S. Levy 

RDI: G. Kramer (RAB1): 19-APR-2013; DE SAC Reviewers: 19-APR-2013

S. Levy:S10953:PY-S:(703) 305-0783:7509P:RAB1
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Attachment 1: DEEM-FCID Acute Food + Drinking Water Residue Input File.

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Acute analysis for PROMETRYN

Residue file name: C:\Documents and Settings\slevy\Desktop\Prometryn\080805_ACUTE.R08

Analysis Date 04-17-2013 Residue file dated: 04-17-2013/15:28:20

Reference dose: aRfD = 0.12 mg/kg bw/day NOEL = 12 mg/kg bw/day

Comment: 2E8052 - new uses on snap beans and dill

----------------------------------------------------------------------------------

 EPA Crop Def Res Adj. Factors Comment

 Code Grp Food Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0601043000 6A Bean, snap, succulent 0.050000 1.000 1.0002E8052

0601043001 6A Bean, snap, succulent-babyfood 0.050000 1.000 1.0002E8052

0402076000 4B Cardoon 0.500000 1.000 1.000

0101078000 1AB Carrot 0.450000 1.000 1.000

0101078001 1AB Carrot-babyfood 0.450000 1.000 1.000

0101079000 1AB Carrot, juice 0.450000 1.000 1.000

0101084000 1AB Celeriac 0.050000 1.000 1.000

0402085000 4B Celery 0.500000 1.000 1.000

0402085001 4B Celery-babyfood 0.500000 1.000 1.000

0402086000 4B Celery, juice 0.500000 1.000 1.000

0402087000 4B Celtuce 0.500000 1.000 1.000

1901118000 19A Cilantro, leaves 9.000000 1.000 1.000

1901118001 19A Cilantro, leaves-babyfood 9.000000 1.000 1.000

2003128000 20C Cottonseed, oil 0.250000 1.000 1.000

2003128001 20C Cottonseed, oil-babyfood 0.250000 1.000 1.000

1902143000 19B Dill, seed 1.100000 1.000 1.0002E8052

1901144000 19A Dillweed 0.300000 1.000 1.0002E8052

0402152000 4B Fennel, Florence 0.500000 1.000 1.000

0802234000 8BC Okra 0.050000 1.000 1.000

0401248000 4A Parsley, leaves 0.600000 1.000 1.000

1901249000 19A Parsley, dried leaves 1.500000 1.000 1.000

1901249001 19A Parsley, dried leaves-babyfood 1.500000 1.000 1.000

0101250000 1AB Parsley, turnip rooted 0.450000 1.000 1.000

0603258000 6C Pea, pigeon, seed 0.250000 1.000 1.000

0602259000 6B Pea, pigeon, succulent 0.250000 1.000 1.000

0402322000 4B Rhubarb 0.500000 1.000 1.000

0402367000 4B Swiss chard 0.500000 1.000 1.000

8601000000 86A Water, direct, all sources 0.377400 1.000 1.000

8602000000 86B Water, indirect, all sources 0.377400 1.000 1.000
Prometryn Dietary Exposure and Risk Assessment DP# 408528

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Attachment 2: DEEM-FCID Acute Exposure Estimates for Females 13 to 49 Years Old.

US EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for PROMETRYN NHANES 2003-2008 2-Day

Residue file: 080805_ACUTE.R08 Adjustment factor #2 used.

Analysis Date: 04-17-2013/15:29:05 Residue file dated: 04-17-2013/15:28:20

NOEL (Acute) = 12.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: "2E8052 - new uses on snap beans and dill"

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Female 13-49:

 0.020659 17.22 580 0.030331 25.28 395 0.042444 35.37 282 
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Attachment 4: DEEM-FCID Chronic Food + Drinking Water Residue Input File.

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for PROMETRYN

Residue file: C:\Documents and Settings\slevy\Desktop\Prometryn\080805_CHRONIC.R08

 Adjust. #2 used

Analysis Date 04-17-2013 Residue file dated: 04-17-2013/15:24:32

Reference dose (RfD) = 0.04 mg/kg bw/day

----------------------------------------------------------------------------------

Food Crop Residue Adj. Factors

EPA Code Grp Food Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------

0601043000 6A Bean, snap, succulent 0.050000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.050000 1.000 1.000 

0402076000 4B Cardoon 0.500000 1.000 1.000 

0101078000 1AB Carrot 0.450000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.450000 1.000 1.000 

0101079000 1AB Carrot, juice 0.450000 1.000 1.000 

0101084000 1AB Celeriac 0.050000 1.000 1.000 

0402085000 4B Celery 0.500000 1.000 1.000 

0402085001 4B Celery-babyfood 0.500000 1.000 1.000 

0402086000 4B Celery, juice 0.500000 1.000 1.000 

0402087000 4B Celtuce 0.500000 1.000 1.000 

1901118000 19A Cilantro, leaves 9.000000 1.000 1.000 

1901118001 19A Cilantro, leaves-babyfood 9.000000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.250000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.250000 1.000 1.000 

1902143000 19B Dill, seed 1.100000 1.000 1.000 

1901144000 19A Dillweed 0.300000 1.000 1.000 

0402152000 4B Fennel, Florence 0.500000 1.000 1.000 

0802234000 8BC Okra 0.050000 1.000 1.000 

0401248000 4A Parsley, leaves 0.600000 1.000 1.000 

1901249000 19A Parsley, dried leaves 1.500000 1.000 1.000 

1901249001 19A Parsley, dried leaves-babyfood 1.500000 1.000 1.000 

0101250000 1AB Parsley, turnip rooted 0.450000 1.000 1.000 

0603258000 6C Pea, pigeon, seed 0.250000 1.000 1.000 

0602259000 6B Pea, pigeon, succulent 0.250000 1.000 1.000 

0402322000 4B Rhubarb 0.500000 1.000 1.000 

0402367000 4B Swiss chard 0.500000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.157900 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.157900 1.000 1.000 
Prometryn Dietary Exposure and Risk Assessment DP# 408528

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Attachment 5: DEEM-FCID Chronic Exposure Estimates.

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for PROMETRYN NHANES 2003-2008 2-day

Residue file name: C:\Documents and 

Settings\slevy\Desktop\Prometryn\080805_CHRONIC.R08

 Adjustment factor #2 used.

Analysis Date 04-17-2013/15:30:54 Residue file dated: 04-17-2013/15:24:32

Reference dose (RfD, Chronic) = .04 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.003426 8.6%

Hispanic 0.003286 8.2%

Non-Hisp-White 0.003521 8.8%

Non-Hisp-Black 0.002813 7.0%

Non-Hisp-Other 0.003980 10.0%

Nursing Infants 0.003425 8.6%

Non-Nursing Infants 0.011607 29.0%

Female 13+ PREG 0.003193 8.0%

Children 1-6 0.004520 11.3%

Children 7-12 0.002890 7.2%

Male 13-19 0.002344 5.9%

Female 13-19/NP 0.002621 6.6%

Male 20+ 0.003171 7.9%

Female 20+/NP 0.003576 8.9%

Seniors 55+ 0.003305 8.3%

All Infants 0.009081 22.7%

Female 13-50 0.003382 8.5%

Children 1-2 0.005136 12.8%

Children 3-5 0.004274 10.7%

Children 6-12 0.003041 7.6%

Youth 13-19 0.002484 6.2%

Adults 20-49 0.003390 8.5%

Adults 50-99 0.003366 8.4%

Female 13-49 0.003377 8.4%

-------------------------------------------------------------------------------