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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-K





(Mark One)

|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended June 30, 2010

OR



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from              to

Commission file number: 001-34275





MYREXIS, INC.

(Exact name of registrant as specified in its charter)







|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 26-3996918                          
|(State or other jurisdiction of
incorporation or organization) |  | (I.R.S. Employer
Identification No.)
|                                                               | 
|305 Chipeta Way
Salt Lake City, Utah                           |  | 84108                               
|(Address of principal executive offices)                       |  | (Zip Code)                          

Registrants telephone number, including area code (801) 214-7800

Securities registered pursuant to Section 12(b) of the Exchange Act:



|                                                                        |  |                                          
|----------------------------------------------------------------------- |  | -----------------------------------------
|Title of each class                                                     |  | Name of each exchange on which registered
|Common Stock, $0.01 Par Value Per Share
Preferred Share Purchase Rights |  | The NASDAQ Stock Market LLC              

Securities registered pursuant to Section 12(g) of the Exchange Act: None.





Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities
Act.    Yes   ̈    No  x

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Exchange
Act.    Yes   ̈    No  x

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past
90 days.    Yes  x    No   ̈

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive
Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such
files).    Yes   ̈    No   ̈

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and
will not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K.  x

Indicate by check mark whether the registrant is
a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of large accelerated filer, accelerated filer, and smaller reporting company in
Rule 12b-2 of the Exchange Act.



|                           |  |                      |  |                                              |  |                             
|-------------------------- |  | -------------------- |  | -------------------------------------------- |  | ----------------------------
|Large accelerated filer   ̈ |  | Accelerated filer  x |  | Non-accelerated filer   ̈                     |  | Smaller reporting company   ̈
|                           |  |                      |  | (Do not check if a smallerreporting company) |  |                             

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of
the Exchange Act).    Yes   ̈    No  x

The aggregate market value of the registrants common stock held by non-affiliates of the registrant (without admitting that any
person whose shares are not included in such calculation is an affiliate) computed by reference to the price at which the common stock was last sold December 31, 2009, the last business day of the registrants most recently completed
second fiscal quarter, was $123,314,736. As of September 7, 2010 the registrant had 25,241,469 shares of common stock outstanding.

DOCUMENTS INCORPORATED BY REFERENCE

The following documents (or parts thereof) are incorporated by reference into the following parts of this Form 10-K: Certain
information required in Part III of this Annual Report on Form 10-K is incorporated from the registrants Proxy Statement for the Annual Meeting of Stockholders to be held on November 11, 2010.









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Forward-looking Statements

This Annual Report on Form 10-K contains forward-looking statements within the meaning of Section 27A of the Securities
Act of 1933, as amended, and Section 21E of the Securities and Exchange Act of 1934, as amended. All statements other than statements of historical facts are forward-looking statements for purposes of these provisions, including any
statements relating to the plans and objectives of management for future operations, the progress, scope or duration of the development of any of our drug candidates, such as the size, design, population, conduct or objective of any clinical trial,
the timing for initiation or completion of or availability of results from any clinical trial or for submission or approval of any regulatory filing or for meeting with regulatory authorities, or any indication for which any of our drug candidates
may be developed, the benefits that may be derived from any of our drug candidates; or any statements concerning proposed new products or licensing or collaborative arrangements, any statements regarding future economic conditions or performance,
and any statement of assumptions underlying any of the foregoing. In some cases, forward-looking statements can be identified by the use of terminology such as may, will, expects, plans,
anticipates, estimates, potential, or continue or the negative thereof or other comparable terminology. Although we believe that the expectations reflected in the forward-looking statements contained
herein are reasonable, there can be no assurance that such expectations or any of the forward-looking statements will prove to be correct, and actual results could differ materially from those projected or assumed in the forward-looking statements.
Our future financial condition and results of operations, as well as any forward-looking statements, are subject to inherent risks and uncertainties, including but not limited to the risk factors set forth in Item 1A Risk Factors
below, and for the reasons described elsewhere in this Annual Report. All forward-looking statements and reasons why results may differ included in this Annual Report are made as of the date hereof, and we assume no obligation to update these
forward-looking statements or reasons why actual results might differ.

As used in this Annual Report on Form 10-K, the terms
we, us, our, the Company, and Myrexis mean Myrexis, Inc. (unless the context indicates a different meaning). In addition, these terms refer to the former research and drug development
businesses that were integrated with and operated by Myriad Genetics, Inc. prior to June 30, 2009, which are now operated by Myrexis, Inc.



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PART I



|Item 1. | BUSINESS
|------- | --------

Overview

We are a biotechnology company focused on discovering, developing and commercializing novel treatments for cancer. Our development
pipeline includes clinical and pre-clinical product candidates with distinct mechanisms of action and novel chemical structures that have the potential to be first-in-class and/or best-in-class therapeutics. The discovery and development
of each of our drug candidates has been guided by a unique understanding of the genetic causes of human diseases, the genetic factors that may cause drug side effects, drug interactions, and drug metabolism. Our extensive experience in human
genetics, protein-protein interaction technology and chemical proteomic drug discovery has allowed identification of novel drug targets and accelerated progression from chemical lead compounds to investigational drug candidates.

We currently retain all rights to all of our drug candidates and programs across all geographic markets and therapeutic indications. Our
strategy includes establishing our own commercial infrastructure in the United States and entering into clinical development and commercial collaborations.

Our Drug Candidates

The
following table summarizes our most advanced drug candidates currently in development:



|         |  |                             |  |                                           |  |                |  |                                                                                                                                            
|-------- |  | --------------------------- |  | ----------------------------------------- |  | -------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------
|         |  | Drug Candidate              |  | Disease                                   |  | Clinical Stage |  | Status*                                                                                                                                    
|Oncology |  | Azixa (verubulin, MPC-6827) |  |                                           |  |                |  |                                                                                                                                            
|         |  | Microtubule
Destabilizer    |  | Glioblastoma (combination therapy)        |  | Phase 2        |  | Ongoing single arm study in combination with carboplatin. Preliminary results reported in June 2010. Final results expected by end of 2010.
|         |  |                             |  |                                          
|         |  |                             |  | Metastatic Melanoma
(combination therapy) |  | Phase 2        |  | Single arm study in combination with temozolomide. Final results reported in June 2010.                                                    
|         |  |                             |  |                                          
|         |  |                             |  | Glioblastoma (monotherapy)                |  | Phase 2        |  | Initiated in 2Q 2009. Expected to be completed by end of 2010.                                                                             
|         |  |                             |  |                                          
|         |  |                             |  | Glioblastoma                              |  | Phase 2b       |  | Two arm study in combination with temozolomide in patients newly diagnosed with Glioblastoma multiforme. Expected to initiate in 4Q 2010.  
|         |  |                             |  |                                          
|         |  | MPC-3100                    |  |                                           |  |                |  |                                                                                                                                            
|         |  | Hsp90 Inhibitor             |  | Cancer                                    |  | Phase 1        |  | Preliminary results reported in November 2009. Expected to be completed by end of 2010.                                                    
|         |  |                             |  |                                          
|         |  | MPC-9528                    |  |                                           |  |                |  |                                                                                                                                            
|         |  | Cancer Metabolism Inhibitor |  | Cancer                                    |  | Preclinical    |  | Expect to submit IND in 1H 2011.                                                                                                           



|* | All dates are for calendar year ending December 31.
|- | ---------------------------------------------------

We currently do not have any drugs that are commercially available and none of our drug candidates have obtained approval of the U.S.
Food and Drug Administration, or FDA, or any similar foreign regulatory authority.



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Our Clinical-Stage Oncology Programs

We currently have two clinical-stage programs in oncology:



| |  |  | Azixa. Azixa is our most advanced cancer drug candidate and is being developed for the treatment of advanced primary and metastatic tumors with
brain involvement. Azixa is currently in two Phase 2 clinical trials to determine its efficacy in Glioblastoma multiforme, or GBM. In the fourth quarter of 2010, we expect to initiate a two arm Phase 2b trial of Azixa in combination with the
standard of care therapy including radiation treatment and temozolomide compared to the standard of care therapy alone in patients newly diagnosed with GBM.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | MPC-3100. MPC-3100 is an Hsp90 inhibitor we are developing for the treatment of cancer. In the second quarter of 2009, we initiated a Phase 1
open-label, dose-finding, multiple-dose clinical trial in patients with refractory or relapsed cancers, including solid tumors, lymphomas and leukemias. We expect to complete this study by the end of 2010.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Oncology Market Opportunity

The World Health Organization estimates that 12.4 million people were diagnosed with cancer worldwide in 2008, and projected
8.1 million people will die from the disease this year. Global cancer cases and deaths are expected to rise by around 70% in the next 20 years. The American Cancer Society estimated that approximately 1.5 million people in the United
States will be diagnosed with cancer in 2010, and approximately 569,490 people will die from the disease. According to a 2009 IMS Health report, oncology products are the largest therapeutic class of pharmaceuticals in the world, with global sales
of over $52.4 billion in 2009.

Azixa: Our Lead Drug Candidate for the Treatment of Cancer

Background

Cancers are diseases characterized by abnormal and uncontrolled cell growth and division, typically leading to tumor formation. As a tumor
grows, it can directly disrupt organ function at its site of origin. In addition, cancer cells can also spread to other organs, such as the brain, bones and liver, by a process called metastasis. The growth of metastatic tumors at these new sites
can disrupt the function of these other organs. There are many kinds of cancer, but all are characterized by uncontrolled growth of abnormal cells. Cancer tumors cannot grow more than a few millimeters in size, nor can they spread without developing
their own network of blood vessels to supply oxygen and nutrients. Anticancer therapies typically consist of drugs which either directly inhibit uncontrolled cell growth and division or restrict oxygen supply to the tumor.

Glioblastoma multiforme, or GBM, is a type of brain tumor and is amongst the most highly vascularized tumors, characterized by abnormal
vessel structure and unique vascular cells. This vascular hyperplasia is believed to be essential to the rapid growth of the tumor and may offer an opportunity for treatment by agents that are both able to penetrate the brain and selectively disrupt
tumor vasculature. The American Cancer Society estimated the incidence of primary central nervous system, or CNS, tumors in the United States in 2007 as 21,810. GBM represents approximately 15-20% of primary brain tumors and prognosis remains poor
with median survival estimated to be between 12 to 18 months from the time of diagnosis.

For GBM, first line treatment is
surgical resection followed by radiation and administration of temozolomide. At recurrence, there is less guidance, usually resection if possible, re-irradiation and treatment with another systemic chemotherapy or immunotherapy. The treatment of
patients with recurrent primary brain tumors is problematic, as the majority of patients with GBM are not candidates for re-operation due to tumor size and location, or poor performance status and only modestly effective therapeutic modalities are
available. These therapies include drugs that kill cancer cells, or cytotoxic agents, radioactive seed implants, stereotactic radiotherapies or immunotherapy. Responses to chemotherapy regimes are generally palliative, reducing symptoms but not
effecting a cure, and of limited duration. Stereotactic radiotherapies, such as radiosurgery or



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implants, benefit a minority of patients due to the large size and infiltrative nature of recurrent malignant gliomas. Additional fractionated external beam irradiation has only a modest effect
on the growth of recurrent tumors and often exacerbates neurologic toxicity.

Few clinical trials address the issue of
recurrent GBM and the majority of trials have suffered from comparatively small numbers of highly selected patients treated with a particular therapy. New treatments for GBM are clearly needed.

Melanomas, like GBM, are highly vascularized tumors. There are expected to be approximately 62,000 Americans diagnosed with melanoma this
year. Advanced metastatic melanoma is associated with a poor prognosis, and effective treatment options are limited. Patients with stage IV melanoma generally have a median survival of only six to nine months, and a low probability of 10% to 20% for
five-year survival. Up to 75% of patients with metastatic melanoma develop brain metastases during the course of their disease. In fact, patients with metastatic melanoma who respond to aggressive systemic therapy often relapse with metastases in
the CNS. Once patients develop brain metastases, treatment is palliative. Surgery and radiosurgery can produce effective palliation in selected cases but are usually restricted to patients with solitary CNS lesions. Radiation therapy is the current
standard of care for multiple brain metastases and it can improve neurologic symptoms but does not alter disease outcome. Metastatic melanoma is poorly responsive to chemotherapy, with dacarbazine being the most widely used agent for treatment.
Temozolomide is not an FDA-approved therapy for melanoma but is sometimes used, as recent studies indicate patients treated with temozolomide experienced an improvement in quality of life without increasing overall survival. However, only 20% of the
temozolomide plasma concentration penetrates the blood brain barrier. Novel agents with better brain penetration are needed.

Azixa Overview

Azixa is a novel, small molecule drug candidate that acts as a microtubule destabilizing agent, causing arrest of cell division and
programmed cell death, or apoptosis, in cancer cells. Azixa has also been shown to be a vascular disrupting agent, or VDA, in a mouse model of human ovarian cancer. Thus, Azixa has a dual mode of action; it induces apoptosis and acts as a VDA,
resulting in tumor cell death. Importantly, in non-clinical studies, Azixa has demonstrated the unique ability to effectively cross the blood-brain barrier and accumulate in the brain. Azixa does not appear to be subject to multiple drug resistance.

Azixa: Preclinical Development

In vitro mechanism of action studies have shown that Azixa binds to tubulin and destabilizes microtubules, which are cellular
structures that play an important role in cell division and proliferation. This leads to inhibition of cell division and apoptosis. However, unlike other tubulin binding drugs, such as vincristine, vinblastine and vinorelbine, and the
chemotherapeutic class of drugs known as taxanes, such as paclitaxel and docetaxel, Azixa does not appear to be a substrate for multidrug resistance pumps. The activity of Azixa in multidrug resistant cell lines was similar to its activity in
nonresistant cell lines. Azixa has demonstrated potent activity in multiple cancer cell types, including glioma, melanoma, colon cancer, pancreatic cancer, breast cancer and ovarian cancer. In mice, Azixa significantly inhibited the growth of a
variety of subcutaneously implanted tumor lines.

Azixa has also been shown to act as a VDA in a mouse model of human ovarian
cancer. Thus, Azixa has a dual mode of action; it induces apoptosis and acts as a VDA, resulting in tumor cell death. VDAs have been established to reduce interstitial pressure in the tumor microenvironment which may increase local exposure to
cytotoxic chemotherapy. Consistent with this hypothesis, Azixa has been demonstrated to act synergistically with the chemotherapeutic agent carboplatin in this mouse model of ovarian cancer. Accordingly, we believe Azixa has the potential to be used
either in combination with cytotoxic chemotherapies or as a single agent.

The distribution of Azixa into the CNS was
evaluated in mice and the time to maximum drug concentration was the same in both plasma and brain tissue, indicating that Azixa distributed rapidly into the CNS. Remarkably, Azixa concentration in the brain was 14 fold that in the plasma. Similar
studies were performed in



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dogs and demonstrated a 30 fold higher concentration in the brain. These data suggest that it is possible to reach therapeutic drug concentrations of Azixa in the CNS with minimal systemic
exposure. Based on these results, we tested the anti-tumor activity (tumor growth and survival) of Azixa in a mouse model in which human glioma cells had been implanted in the brain. This study showed a statistically significant reduction in tumor
burden and a statistically significant increase in survival when compared to vehicle treated mice.

Azixa: Completed
Clinical Development

In 2007, we completed two open-label, dose-escalating, multiple dose Phase 1 clinical trials to
investigate the safety, tolerability and pharmacokinetics of Azixa and to observe for any evidence of anti-tumor activity in treatment of a variety of refractory solid tumors with and without brain metastases. In these Phase 1 trials, six out of 66
subjects had stable disease ranging from five to 16 months and there was no evidence of CNS toxicities or development of peripheral neuropathies.

Azixa: Ongoing and Planned Clinical Development

In 2008, we initiated recruitment of patients for an open-label, dose finding, multiple-dose Phase 2 clinical trial to confirm the safety
profile of Azixa in combination with the chemotherapeutic agent carboplatin in subjects with recurring/relapsing GBM. In this study, 19 patients with recurrent GBM received one of three dose levels of Azixa administered in combination with a fixed
dose of carboplatin. All patients had failed previous standard of care treatment with temozolomide. Study endpoints included determination of the maximum tolerated dose, dose limiting toxicities, and evaluation of evidence of anti-tumor activity of
Azixa when given with carboplatin as judged by response rate and progression-free survival, or PFS. In June of 2010, we reported initial results from this study at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.
The combination of Azixa at all three concentrations with a fixed dose of carboplatin, including the previously determined single agent maximum tolerated dose of Azixa, was well-tolerated. A dose reduction of Azixa was not required when combined
with carboplatin in these patients. In this study, initial results showed six subjects achieved stable disease and two subjects had achieved partial responses. One subjects partial response duration was 7.8 months; the additional
patients response was, at that time, 16 months in duration and has been classified by his physician as almost a complete response. The overall response rate was 42% as defined by partial response and stable disease evaluated using MacDonald
criteria. Additional data collection is ongoing in this study and final results are expected by the end of 2010.

In 2008, we
initiated an open-label, dose finding, multiple-dose Phase 2 clinical trial to confirm the safety profile of Azixa in combination with the chemotherapeutic agent temozolomide, the current standard of care for recurrent metastatic melanoma, and to
look for evidence of reduced tumor burden and improved survival. The protocol allowed us to enroll up to 36 subjects in this trial, however, we determined that 22 subjects was sufficient to answer the questions regarding the safety profile of Azixa
in combination with temozolomide and we completed enrollment with a total of 22 subjects. This trial explored Azixas efficacy in patients with metastatic melanoma (Stage IV) with and without confirmed CNS metastases. Three separate cohorts of
patients with metastatic melanoma received escalating dose levels of Azixa administered in combination with a fixed dose of temozolomide. Study endpoints included determination of the maximum tolerated dose, dose limiting toxicities, and evaluation
of evidence of anti-tumor activity of Azixa when given with temozolomide as judged by response rate and PFS. In November 2009, we reported initial results from this study at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics meeting in
Boston. In June of 2010, we reported final results from this study at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago. Twenty-two patients with refractory metastatic melanoma were studied at three different doses of
Azixa. The combination of Azixa at all concentrations with fixed dose temozolomide, including the previously determined single agent maximum tolerated dose of Azixa, was well-tolerated. A dose reduction of Azixa was not required when combined with
temozolomide in these patients. In this study, two patients achieved partial response durations of four and 10 months. Nine patients experienced stable disease durations between three and seven months. The response rate (defined as partial response
by modified RECIST criteria and stable



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disease) was 50% and the median PFS of patients in the metastatic melanoma study was 2.9 months. While the results from this study are encouraging, because of the small number of patients in the
trial, the results were not statistically significant, and we cannot assure you that we will achieve positive results and/or positive results with statistical significance in subsequent clinical trials of Azixa in combination with temozolomide.

In the second quarter of 2009, we initiated an open-label Phase 2 clinical trial to evaluate Azixa as monotherapy in patients
with recurrence of GBM, including a cohort of patients who have never been treated with bevacizumab and a cohort of patients who have recurrence of GBM following treatment with bevacizumab. In this trial, PFS will be evaluated as the primary
endpoint, with safety, pharmacokinetic parameters and overall survival as secondary endpoints. We have completed enrollment of 56 patients in this trial and expect the study to be completed in the clinic by the end of 2010.

In the fourth quarter of 2010, we expect to initiate a two arm Phase 2b trial of Azixa in combination with standard of care therapy
including radiation treatment and temozolomide compared to the standard of care therapy alone in patients newly diagnosed with GBM.

Azixa: Safety Summary

In completed and ongoing clinical trials in which a total of 163 subjects have been treated with Azixa, 12 serious adverse events in 11
subjects have been reported as possibly, probably or definitely related to Azixa: non fatal myocardial infarction (single events in three subjects), cerebral hemorrhage (single events in two subjects), cerebral ischemia (one event in one subject),
troponin I increase (one event in one subject), hypersensitivity (two events in one subject), pulmonary embolism (one event in one subject), hypertension (one event in one subject), and headache (one event in one subject). To date, the overall
incidence of myocardial infarction is 1.8%, the incidence of cerebral hemorrhage is 1.2% and the incidence of cerebral ischemia, pulmonary embolism, hypertension, headache and troponin I increase is 0.6% each.

MPC-3100 for the Treatment of Cancer

Background

Heat shock protein 90, or Hsp90, is a chaperone protein that plays an important role in regulating the activity and function of numerous
signaling proteins, or client proteins, that trigger proliferation of cancer cells. Important client proteins in cancer include steroid hormone receptors, oncogenes, protein kinases, mutant p53, and telomerase h-TERT. Hsp90 binds and stabilizes
these client proteins and inhibition of Hsp90 leads to degradation of the client proteins important for growth and, sometimes, survival of the tumor.

Early Hsp90 inhibitors were analogs of the natural product molecule geldanamycin that demonstrated promising preclinical and clinical
proof of concept activity, but have been challenging to develop because of drug related toxicities, including hepatotoxicity, nephrotoxicity and pancreatitis. These toxicities do not appear to be related to inhibition of Hsp90. Additional
limitations to geldanamycin derivatives include poor solubility, metabolic stability and difficulty in administration.

MPC-3100 is a fully synthetic, orally bio-available, non-geldanamycin compound that has shown significant and broad preclinical
anti-tumor activity in mouse models of human cancers. MPC-3100 has not demonstrated the same hepatic or renal toxicity in vivo as the geldanamycin analogs. MPC-3100 inhibits Hsp90 by binding to the same site as geldanamycin and has displayed
potent anticancer activity in several in vitro and in vivo models. MPC-3100 significantly and dose-dependently reduced tumor growth in multiple studies conducted in mice implanted with a variety of human cancer cell lines, including
colon, prostate, myeloid leukemia, small cell lung, gastric, breast, and ovarian cancers.

MPC-3100: Development

We submitted an investigational new drug application, or IND, for MPC-3100 in the first quarter of 2009 and initiated
patient enrollment of a Phase 1 clinical trial in the second quarter of 2009 to investigate the safety



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and tolerability of MPC-3100, pharmacokinetics, and the potential for anti-tumor activity. This trial is an open-label, multiple-dose, dose escalation design in up to 40 subjects with refractory
or relapsed cancer. Physical examination findings, electrocardiograms, pharmacokinetics, clinical laboratory parameters, and adverse events will be evaluated in subjects at each dose level to assess safety. Disease progression will be evaluated
using standard clinical practice guidelines for each patients cancer type. In this ongoing study, MPC-3100 has been observed to be orally bio-available in cancer patients. In November 2009, we presented the preliminary results of this ongoing
study at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics meeting in Boston. Preliminary data to date have demonstrated that MPC-3100 is orally-bio-available in cancer patients with a half life of approximately 12 hours. Drug absorption
has not been maximized and continues to increase with increasing dose. Plasma concentrations in patients are comparable to those found to inhibit tumor growth in non-clinical studies. Moreover, these concentrations of MPC-3100 were achieved in
patients in the absence of dose-limiting toxicities. We expect to complete this trial in the clinic by the end of 2010 and are currently planning to initiate a Phase 2 clinical trial of MPC-3100 in 2011.

MPC-3100: Safety Summary

In the ongoing Phase 1 clinical trial, 17 subjects have been treated with MPC-3100. Four serious adverse events in three subjects have
been reported as possibly or probably related to MPC-3100: abdominal pain (single event in a single patient), respiratory failure and supraventricular tachycardia (two events in a single patient), and vomiting (single event in a single patient).

Suspension of HIV Maturation Inhibitor Programs

In June 2010, we announced the suspension of our HIV maturation inhibitor programs for strategic and business reasons. We will continue to
aggressively seek partners for these clinical (MPC-4326, MPC-9055) and preclinical stage (MPI-461359) HIV drug candidates.



| |  |  | MPC-4326. MPC-4326 is a first-in-class small molecule inhibitor of HIV-1 maturation being developed for the oral treatment of HIV
infection. To date, over 740 subjects, including over 180 HIV-infected patients, have been studied in clinical trials of MPC-4326. Results from these trials have shown MPC-4326 to be well tolerated and have demonstrated significant and clinically
relevant reductions in viral load.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | MPC-9055.MPC-9055 is also a small molecule inhibitor of HIV-1 maturation being developed for the oral treatment of HIV infection.
MPC-9055 is ready to begin Phase 2 clinical development.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | MPI-461359.MPI-461359 is a potent, orally available maturation inhibitor being developed for the treatment of HIV. MPI-461359 was
discovered in a medicinal chemistry program as a potent, broad acting small molecule inhibitor of HIV-1 maturation.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Our
Preclinical Programs

Our proprietary research is primarily focused on oncology. We are investigating a number of potential
drug targets as well as screening potential drug candidates against novel targets and optimizing those drug candidates that appear to have the greatest potential. Our most advanced preclinical drug candidates are:



| |  |  | MPC-9528. MPC-9528 is an orally-bio-available, potent, and selective small molecule Cancer Metabolism Inhibitor (CMI) being developed by us for
the treatment of cancer. MPC-9528 inhibits Nicotinamide phosphoribosyltransferase (Nampt) in vitro and in cells at picomolar drug concentrations and is tumoricidal in every cancer line tested to date representing 15 different tumor
tissue types. MPC-9528 displays on-target activity in tumor cells by potently reducing Nicotinamide Adenine Dinucleotide (NAD) levels, which leads to inhibition of glycolysis, energy deprivation and cell death, while NAD in normal tissues is less
affected. In in vitro preclinical efficacy studies, MPC-9528 causes dramatic tumor regressions in multiple tumor types when administered orally with either a low daily
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | dose or higher intermittent dose schedule. The NAD-reducing and tumoricidal activity of MPC-9528 can be completely blocked by nicotinic acid (niacin, Vitamin B3). Nicotinic acid is converted to
NAD through an alternative pathway that is dependent upon the enzyme Nicotinic acid phosphoribosyltransferase (Naprt1) and does not utilize Nampt. Through experiments at our facilities, approximately 40% of tumor cell lines were found to be
deficient in Naprt1 and in these cells, nicotinic acid had little to no effect on MPC-9528 tumoricidal activity. Furthermore, we found that combining nicotinic acid with MPC-9528 increases the tolerated MPC-9528 dose while still causing tumoricidal
effects on xenograft tumors deficient in Naprt1. This demonstrates the potential to combine nicotinic acid and MPC-9528 to treat patients with tumors that are deficient in Naprt1. A diagnostic method designed to measure Naprt1 expression could be
used to identify those patients with Naprt1 deficient tumors that are most likely to respond to the combination therapy. Results from our preclinical studies of MPC-9528, were presented at the
101stAnnual Meeting of the American Association for
Cancer Research, or AACR, in April of 2010 in Washington DC. Based on the data to date, we expect to complete preclinical studies of MPC-9528 in the first half of 2011 and advance the candidate into human clinical studies.
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | MPI-485520. MPI-485520 is an oral anti-interferon. MPI-485520 potently and selectively inhibits
IKKe/TBK1and is being developed by us for cancer and diseases that result from chronic inflammation. MPI-485520 exhibits high oral bio-availability, favorable ADME/PK properties, and efficacy in
an in vivo mouse model. In cellular models of type I interferon production, MPI-485520 potently inhibits induction of type I interferons
(IFNa/b) following stimulation of a variety of receptors such as TLR3, TLR4, RIG-I, and MDA-5. Inhibition of other pro-inflammatory cytokines is also
observed. Inhibition of type I interferon production by IKKe/TBK1 inhibitors may benefit patients with autoimmune disorders such as rheumatoid arthritis, systemic lupus erythematosus (SLE), scleroderma,
Sjögrens syndrome, and polymyositis. IKKe has previously been shown to be an oncogene in breast cancer. Studies in in vivo models have additionally demonstrated a role for
IKKe in the pathology of rheumatoid arthritis. Our current efforts are focused on the development of IKKe/TBK1 inhibitors for rheumatoid arthritis and
SLE.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | MPI-443803.MPI-443803 is an orally available, brain penetrant, microtubule destabilizing agent we are evaluating for the treatment of
cancer. MPI-443803 was developed in an extensive medicinal chemistry effort to produce an orally bio-available analogue of Azixa. Like Azixa, MPI-443803 is a potent inducer of apoptosis that prevents the polymerization of tubulin into microtubules.
In preclinical studies, MPI-443803 has shown pro-apoptotic activity in multiple cancer types including pancreatic, breast, colorectal, non-small cell lung, melanoma, ovarian and leukemia. MPI-443803 has also demonstrated excellent oral
bio-availability, crosses the blood brain barrier and accumulates in the CNS. We believe that MPI-443803 may be a promising candidate for development as an oral alternative to Azixa or for chronic use to prevent metastases in the brain.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | MPI-487109. MPI-487109 is a novel, potent fully-synthetic, highly orally-bio-available, small molecule inhibitor of Hsp90. MPI-487109 is being
evaluated by us as a follow-on drug candidate to MPC-3100.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Our Drug Discovery Capabilities

The advancements in cancer therapy have been impressive since the advent of molecular target-based drug discovery. However, cancer remains
a complex and inadequately understood disease with a continued need for new targeted therapies. Our drug discovery capabilities were born over a decade ago with a mandate to capitalize on the emerging genomics revolution to find new cancer targets.
Since then, our drug discovery capabilities have matured into a fully integrated and self sufficient operation that includes target discovery and validation, high-throughput screening, chemical proteomics, medicinal and computational chemistry,
in vitro and in vivo pharmacology and ADME, or absorption, distribution, metabolism and excretion, pharmacokinetics and toxicology characterization. Many of our drug discovery scientists have worked previously in leading



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biotechnology and pharmaceutical companies. The resulting discovery engine now has a proven track record of consistently producing new drug candidates for preclinical development. We have an
extensive library of compounds with drug-like properties which includes selective kinase inhibitors. Many of these compounds are covered by issued and pending patents owned by us.

Our Discovery Process

Our
process begins with target identification and in vitro validation in which we combine our expertise in cancer genetics and, knowledge of cancer biology with proprietary chemical proteomics technology to identify proteins that are required for
the progression of cancer. Only targets with strong in vitro validation and the potential to generate first-in-class and/or best-in-class therapeutics are selected for further development. Once a cancer target has been selected for drug
discovery, the initial identification of small molecule modulators of target activity is achieved through a combination of high-throughput screening of compound libraries and rational design based on molecular modeling. The identified
hits begin an iterative process involving characterization of compound biochemical and cellular activity relevant to the target and modification of compounds to optimize potency and selectivity based on those activities. After a defined
threshold of potency and selectivity is reached, chemical informatic tools and ADME characterization are used to optimize drug-like properties aimed at selecting compounds for clinical development. The final stage for identifying a drug for
preclinical development involves demonstration of efficacy and safety in appropriate in vivo models, which typically track the ability of a compound to inhibit tumor growth. Success in this preclinical proof-of-concept provides a
model system in which leads can be compared in order to choose the one with the greatest ability to safely kill tumors.

Chemical Proteomics

We have established a chemical proteomics technology that combines small molecule affinity chromatography with mass
spectrometry to identify the cellular targets of compounds in an unbiased manner. One historical limitation of this type of technique is the difficulty in detecting proteins that are very rare in cells. We have overcome this by an extensive
optimization of the chemistry, biochemistry and mass spectrometry techniques involved to allow for detection of rare proteins and, subsequently, for proving that these rare proteins are targets of the compounds being tested. The identification of
cellular targets of compounds with unknown mechanism of action, called de-orphaning, is one important application of our Chemical Proteomics technology. Our cancer metabolism inhibitor program arose from one of our de-orphaning projects.
We also make extensive use of our chemical proteomics to characterize the selectivity of compounds and assist in medicinal chemistry efforts by identifying off-target activities. Off-target screening is used early in our drug discovery
and is incorporated into our iterative discovery process in order to eliminate unwanted activity and produce selective modulators of the desired target.

Our Research Services Capabilities

Because virtually all cellular processes are controlled by proteins, knowledge of specific protein interactions and the functions of the
interacting proteins can be extremely valuable in the identification of novel drug targets for therapeutic development. We have developed and maintain ProNet, an extensive proprietary database of protein-protein interactions which encompasses
interactions between approximately 10 million protein fragments constructed from a variety of organ tissues including heart, brain, kidney, liver, breast and prostate. We offer access to ProNet on a subscription basis to third parties to
examine protein interactions related to a specific disease or disease pathway. In addition, we continue to develop the ProNet database and related yeast-two-hybrid systems for potential commercial partners through contract services which include,
sub-database creation and search, custom library development and assay development.

Research revenue was $90,000, $5.5
million, and $6.8 million for the years ended June 30, 2010, 2009 and 2008, respectively. Research revenue from our contract research agreements is recognized using a proportional performance methodology over the life of each contract.
Consequently, such revenue will fluctuate up or down



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depending upon when we enter into new contracts, complete our obligations under existing contracts and as these individual programs progress and outputs increase or decrease. Our research
services group has had several successful collaborations with public and private institutions and companies. In 2008 and 2009 the majority of our research revenues were derived from whole genome sequencing projects, and recent advances in DNA
sequencing technologies have impacted our ability to compete effectively in this area, reducing both the demand and pricing for our services. Accordingly, our research services group has focused its efforts primarily on ProNet collaborations.
Through these collaborations we have continued to increase the size and scope of our ProNet database. We do not anticipate that these efforts will result in a return of our research revenue to the levels experienced in 2009 and 2008.

Our Strategy

Our
strategy is to discover, develop, and commercialize novel therapies that address severe medical conditions with large markets, with a focus on treatments for cancer. Key elements of our strategy include:



| |  |  | Advance the development of our drug candidates. We plan to advance our drug candidates based on an ongoing assessment of preclinical and
clinical study results and market potential.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Establish collaborative relationships.We may seek to establish research, development and/or commercial collaborations with other companies
in order to maximize the value of our drug candidates and optimize value for our shareholders.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Leverage our drug discovery capabilities. We plan to leverage our extensive experience in drug discovery to expand our pipeline of drug
candidates primarily for the treatment of cancer.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Enrich our pipeline through in-licensing or acquisition.We may acquire or in-license drugs, drug candidates, companion diagnostics or
related technologies and capabilities in order to accelerate our path to marketed pharmaceutical products, reduce risk and increase revenues. We may consider mergers or acquisitions to accomplish these objectives although we have no current plans
for any such transactions.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Commercialize our successful drug candidates.Our drug candidates target large markets primarily treated by specialist physicians. We may
elect to commercialize any approved products ourselves in certain markets in lieu of or in addition to partnering or licensing arrangements with third parties.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Intellectual Property

Our success will depend in part on our ability to obtain and maintain proprietary protection for our drug candidates, technology, and
know-how, to operate without infringing on the proprietary rights of others, and to prevent others from infringing our proprietary rights. Our policy is to seek to protect our proprietary position by, among other methods, filing U.S. and foreign
patent applications related to our proprietary technology, inventions, and improvements that are important to the development of our business. We also rely on trade secrets, know-how, continuing technological innovation, and in-licensing
opportunities to develop and maintain our proprietary position.

We intend to seek patent protection in the United States and
major foreign jurisdictions for drug compounds, pharmaceutical compositions and dosage forms, therapeutic and prophylactic methods, diagnostic methods, processes of manufacturing, and other inventions which we believe are patentable and where we
believe our interests would be best served by seeking patent protection. We also rely upon trade secret rights to protect certain other technologies which may be used in discovering, characterizing, and manufacturing new therapeutic products. To
further protect our trade secrets and other proprietary information, we require that our employees and consultants enter into confidentiality and invention assignment agreements. However, those confidentiality and invention assignment agreements may
not provide us with adequate protection.



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We own or have licensed rights to over 50 issued patents and over 175 patent applications in
the United States and foreign countries. Issued patents expire between 2015 and 2027. Any patent applications which we have filed or will file or to which we have licensed or will license rights may not issue, and patents that do issue may not
contain commercially valuable claims. In addition, any patents issued to us or our licensors may not afford meaningful protection for our products or technology, or may be subsequently circumvented, invalidated or narrowed, or found unenforceable.
Our processes and potential products may also conflict with patents which have been or may be granted to competitors, academic institutions or others. As the pharmaceutical industry expands and more patents are issued, the risk increases that our
processes and potential products may give rise to interferences filed by others in the U.S. Patent and Trademark Office, or to claims of patent infringement by other companies, institutions or individuals. These entities or persons could bring legal
actions against us claiming damages and seeking to enjoin clinical testing, manufacturing and marketing of the related product or process. If any of these actions are successful, in addition to any potential liability for damages, we could be
required to cease the infringing activity or obtain a license in order to continue to manufacture or market the relevant product or process. We may not prevail in any such action and any license required under any such patent may not be made
available on acceptable terms, if at all. Our failure to obtain a license to any technology that we may require to commercialize our technologies or potential products could have a materially adverse effect on our business.

We also rely upon unpatented proprietary technology, and in the future may determine in some cases that our interests would be better
served by reliance on trade secrets or confidentiality agreements rather than patents or licenses. We may not be able to protect our rights to such unpatented proprietary technology and others may independently develop substantially equivalent
technologies. If we are unable to obtain strong proprietary rights to our processes or products after obtaining regulatory clearance, competitors may be able to market competing processes and products.

Others may obtain patents having claims which cover aspects of our products or processes which are necessary for, or useful to, the
development, use or manufacture of our services or products. Should any other group obtain patent protection with respect to our discoveries, our commercialization of potential therapeutic products and methods could be limited or prohibited.

Material Licenses

Our rights to certain patents and technologies have been acquired through license agreements with other corporations or academic
institutions. The license agreements that we consider of particular importance to our business are summarized below.

License and Collaboration Agreement with EpiCept Corporation

In November 2003, Myriad Genetics, Inc., our former parent company, entered into a license and collaboration agreement with Maxim
Pharmaceuticals, Inc. and Cytovia, Inc. All licensed rights of Maxim and Cytovia were subsequently acquired by EpiCept Corporation, and we refer to Maxim, Cytovia and EpiCept collectively herein as EpiCept. In connection with our separation from
Myriad Genetics on June 30, 2009, Myriad Genetics assigned this agreement to us but will remain liable for the performance and observance of our duties and obligations under the agreement. Pursuant to this license agreement, we hold an
exclusive, worldwide right to utilize certain intellectual property rights of EpiCept, including patents, patent applications and know-how that relate to Azixa, in the development and commercialization of products for the treatment or prevention of
any disease or disorder. We have the right to grant sublicenses of licensed rights.

We are obligated to pay EpiCept a royalty
on net sales of products subject to the license. Royalty payments range, based on sales volume, from the mid to high single digits and may be reduced by up to 50% if we are obligated to pay a royalty to a third party in order to make, use or sell
such products, subject to a maximum reduction amount. The license agreement also provides for license fees, research support, and milestone



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payments of up to $23 million based on the occurrence of specified product development related events for each product based on a particular active ingredient, provided that milestone payments
made on a product that is subsequently abandoned may be credited against milestone payment obligations for future products. We are also obligated to make payment of a percentage of certain income received from sublicensees. We are obliged to use
commercially reasonable efforts to develop and commercialize licensed products in major markets, failing which, our rights in a major market could end. As of June 30, 2009, Myriad Genetics had made payments totaling $4 million under the EpiCept
license and collaboration agreement. As of June 30, 2010, we have made no payments under the EpiCept license and collaboration agreement.

We are responsible for filing, prosecuting and maintaining the licensed patent rights, and we bear the majority of costs related to those
activities. We have the right, but not the obligation, to enforce the patent rights against infringement. We are obligated to indemnify EpiCept against any liabilities resulting from our utilization of the licensed patent rights and manufacture and
commercialization of licensed products.

The license agreement ends on the later of ten years after the date of the first
commercial sale of a licensed product or the expiration of EpiCept patent rights covered by the license agreement. These rights are presently not expected to expire until July 2024, based on the last patent issued to date. The license may be sooner
terminated on the bankruptcy or uncured material breach of a party.

License Agreement with University of North Carolina

In January 2009, we entered into a transaction with Panacos Pharmaceuticals, Inc. and the University of North Carolina, or
UNC, through which we were assigned Panacos interest in certain intellectual property rights, including certain know-how and patents that relate to MPC-4326, and licensed the interests of UNC in that intellectual property. Our rights under the
license include exclusive rights under licensed patents on a world-wide basis, and include the right to grant sublicenses.

Under this license agreement we will pay UNC a royalty based on net sales of licensed products. Royalty payments range, based on sales
volume, in the low single digits and may be reduced by up to 50% if we are obligated to pay a royalty to a third party in order to make, use or sell such products, subject to a maximum reduction amount. The license agreement also provides for
milestone payments of up to $225,000 based on the occurrence of specified development and commercialization events for each product based on a particular active ingredient. We are also obliged to pay to UNC a specified share of sublicensing fees we
receive under sublicenses that we grant.

We are obliged to use commercially reasonable efforts to develop and commercialize a
licensed product either directly or through a sublicensee. UNC has the right to terminate the license agreement if we or a sublicensee fail to apply for regulatory approval of a licensed product by a certain date, and to commence commercial sales
within a specified timeframe after regulatory approval of the licensed product, although we may postpone those dates for successive one year periods by making additional payments to UNC.

We may terminate the license agreement on thirty days notice. The license may also be terminated on the bankruptcy or uncured
material breach of a party. If it is not sooner terminated, the license agreement ends on the expiration of the last to expire of the licensed patents, which presently is anticipated in June 2015, based on the last patent issued to date.

We are responsible for filing, prosecuting and maintaining the licensed patent rights, and we bear all costs related to those activities.
We have the right, but not the obligation, to enforce the patent rights against infringement. We are obligated to indemnify UNC against any liabilities resulting from our utilization of the licensed rights.

As of June 30, 2010 we had made no payments under the UNC license agreement.



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Manufacturing and Supply

We currently rely on contract manufacturers to produce drug substances and drug products required for our clinical trials under current
good manufacturing practices, or cGMP, with oversight by our internal managers. We plan to continue to rely upon contract manufacturers or possibly collaboration partners to manufacture commercial quantities of our drug candidates if and when
approved for marketing by the FDA. We currently rely on a single manufacturer for the preclinical or clinical supplies of each of our drug candidates and do not currently have relationships for redundant supply or a second source for any of our drug
candidates. We believe that there are alternate sources of supply that can satisfy our clinical trial requirements without significant delay or material additional costs.

Sales and Marketing

We
may establish our own sales and marketing capabilities if and when we obtain regulatory approval of our drug candidates. Patients in the markets for our drug candidates are largely managed by medical specialists in the areas of oncology,
rheumatology and infectious diseases. Historically, companies have experienced substantial commercial success through the deployment of specialized sales forces which can address a majority of key prescribers. Therefore, we may utilize a specialized
sales force in the United States for the sales and marketing of drug candidates that we may successfully develop. We currently have limited marketing, sales and distribution capabilities. In order to participate in the commercialization of any of
our drugs, we must develop these capabilities on our own or in collaboration with third parties. We may also choose to hire a third party to provide sales personnel instead of developing our own staff. Outside of the United States, and in situations
or markets where a more favorable return may be realized through licensing commercial rights to a third party, we may license a portion or all of our commercial rights in a territory to a third party in exchange for one or more of the following:
up-front payments, research funding, development funding, milestone payments and royalties on drug sales.

Competition

The development and commercialization of new drugs is highly competitive. We will face competition with respect to all drug candidates we
may develop or commercialize in the future from pharmaceutical and biotechnology companies worldwide. The key factors affecting the success of any approved product will be its efficacy, safety profile, drug interactions, method of administration,
pricing, reimbursement and level of promotional activity relative to those of competing drugs. If approved, we would expect our clinical-stage drug candidates, Azixa and MPC-3100, to compete with approved drugs and potentially with drug candidates
currently under development, including the following:



| |  |  | Azixa. If approved, we would expect Azixa to compete with multiple vascular disrupting agents in clinical development (including vadimezan from
Novartis and ombrabulin from sanofi-Aventis, which are currently in Phase 3 development) as well as numerous treatments for glioblastoma in development (including cilengitide from Merck KGaA, which is currently in Phase 3 development) and approved
products, temozolomide, carmustine implants and bevacizumab. If approved for metastatic melanoma, we would expect Azixa to compete with other treatments for metastatic melanoma currently in clinical development (including ipilimumab from
Bristol-Myers Squibb and PLX4032 from Plexxikon/ Roche, which are currently in Phase 3 development) and approved products interleukin-2 and dacarbazine.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | MPC-3100. If approved, we would expect MPC-3100 to compete with natural product derived, geldanamycin-based analogs in development (including
retaspimycin from Infinity, which is in Phase 2 development) and non-geldanamycin small molecule inhibitors of Hsp90 currently in clinical development (including AUY922 from Vernalis/Novartis and STA-9090 from Synta which are in Phase 2
development), as well as other cancer treatments currently approved or in clinical development.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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Many of our potential competitors have substantially greater financial, technical, and
personnel resources than us. In addition, many of these competitors have significantly greater commercial infrastructures. Our ability to compete successfully will depend largely on our ability to leverage our collective experience in drug
discovery, development and commercialization to:



| |  |  | discover and develop medicines that are differentiated from other products in the market;
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | obtain patent and/or proprietary protection for our medicines and technologies;
| | - |  | -------------------------------------------------------------------------------



| |  |  | obtain required regulatory approvals;
| | - |  | -------------------------------------



| |  |  | obtain a commercial partner, especially for larger indications in oncology;
| | - |  | ---------------------------------------------------------------------------



| |  |  | commercialize our drugs, if approved; and
| | - |  | -----------------------------------------



| |  |  | attract and retain high-quality research, development, and commercial personnel.
| | - |  | --------------------------------------------------------------------------------

Government Regulation and Product Approval

Government authorities in the United States, at the federal, state and local level, and other countries extensively regulate, among other
things, the research, development, testing, manufacture, labeling, packaging, promotion, storage, advertising, distribution, marketing and export and import of products such as those we are developing. Our drugs must be approved by the FDA through
the new drug application, or NDA, process before they may be legally marketed in the United States.

United States Government Regulation

NDA Approval Processes

In the United States, the FDA regulates drugs under the Federal Food, Drug and Cosmetic Act, or the FDCA, and implementing regulations.
Failure to comply with the applicable U.S. requirements at any time during the product development process, approval process or after approval, may subject an applicant to administrative or judicial sanctions. These sanctions could include:



| |  |  | the FDAs refusal to approve pending applications;
| | - |  | --------------------------------------------------



| |  |  | license suspension or revocation;
| | - |  | ---------------------------------



| |  |  | withdrawal of an approval;
| | - |  | --------------------------



| |  |  | a clinical hold;
| | - |  | ----------------



| |  |  | warning letters;
| | - |  | ----------------



| |  |  | product recalls;
| | - |  | ----------------



| |  |  | product seizures;
| | - |  | -----------------



| |  |  | total or partial suspension of production or distribution; or
| | - |  | -------------------------------------------------------------



| |  |  | injunctions, fines, civil penalties or criminal prosecution.
| | - |  | ------------------------------------------------------------

Any agency or judicial enforcement action could have a material adverse effect on us. The process of obtaining regulatory approvals and
the subsequent compliance with appropriate federal, state, local, and foreign statutes and regulations require the expenditure of substantial time and financial resources.

The process required by the FDA before a drug may be marketed in the United States generally involves the following:



| |  |  | completion of preclinical laboratory tests according to Good Laboratory Practices;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | submission of an IND, which must become effective before human clinical trials may begin;
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| |  |  | performance of adequate and well-controlled human clinical trials according to Good Clinical Practices to establish the safety and efficacy of the
proposed drug for its intended use;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | submission to the FDA of an NDA;
| | - |  | --------------------------------



| |  |  | satisfactory completion of an FDA inspection of the manufacturing facility or facilities at which the product is produced to assess compliance with
cGMP, to assure that the facilities, methods and controls are adequate to preserve the drugs identity, strength, quality and purity; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | FDA review and approval of the NDA.
| | - |  | -----------------------------------

Once a pharmaceutical candidate is identified for development, it enters the preclinical testing stage. Preclinical tests include
laboratory evaluations of product chemistry, toxicity and formulation, as well as animal studies. An IND sponsor must submit the results of the preclinical tests, together with manufacturing information and analytical data, to the FDA as part of the
IND. Some preclinical or nonclinical testing may continue even after the IND is submitted. In addition to including the results of the preclinical studies, the IND will also include a protocol detailing, among other things, the objectives of the
clinical trial, the parameters to be used in monitoring safety and the effectiveness criteria to be evaluated if the first phase lends itself to an efficacy determination. The IND automatically becomes effective 30 days after receipt by the
FDA, unless the FDA, within the 30-day time period, specifically places the sponsor on clinical hold. In such a case, the IND sponsor and the FDA must resolve any outstanding concerns before clinical trials can begin.

All clinical trials must be conducted under the supervision of one or more qualified investigators in accordance with good clinical
practices, or GCPs, and other requirements. In addition, an institutional review board, or IRB, at each institution participating in the clinical trial must review and approve the plan for any clinical trial before it commences at that institution.
Each new clinical protocol must be submitted to the FDA as part of the IND. Progress reports detailing the results of the clinical trials must be submitted at least annually to the FDA and more frequently if serious adverse events occur.

Human clinical trials are typically conducted in three sequential phases that may overlap or be combined:



| |  |  | Phase 1.The drug is initially introduced into healthy human subjects and tested for safety, dosage tolerance, pharmacokinetics,
pharmacodynamics, absorption, metabolism, distribution and elimination. In the case of some products for severe or life-threatening diseases, especially when the product may be too inherently toxic to ethically administer to healthy volunteers, the
initial human testing is often conducted in patients with the disease.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase 2.The drug is studied in a limited patient population to identify possible adverse effects and safety risks, to preliminarily
evaluate the efficacy of the product for specific targeted diseases and to determine dosage tolerance and optimal dosage.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase 3.Clinical trials are undertaken to further evaluate dosage, clinical efficacy and safety in an expanded patient population. These
studies are intended to establish the overall risk-benefit ratio of the product and provide, if appropriate, an adequate basis for product labeling.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Phase 1, Phase 2, and Phase 3 testing may not be completed successfully within any specified period, if at all. The FDA or
the sponsor may suspend a clinical trial at any time on various grounds, including a finding that the research subjects or patients are being exposed to an unacceptable health risk. In addition, an IRB can suspend or terminate approval of a clinical
trial at its institutions for several reasons, including if the clinical trial is not being conducted in accordance with the IRBs requirements or if the drug has been associated with unexpected serious harm to patients.

During the development of a new drug, sponsors may meet with the FDA. Sponsors typically request meetings prior to submission of an IND,
at the end of Phase 2, and before an NDA is submitted. These meetings can provide an opportunity for the sponsor to share information about the data gathered to date, for the FDA to



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provide advice, and for the sponsor and FDA to reach agreement on the next phase of development. Sponsors typically use the end of Phase 2 meeting to discuss their Phase 2 clinical
results and present their plans for the pivotal Phase 3 clinical trial that they believe will support approval of the new drug. If a Phase 2 clinical trial is the subject of discussion at an end of Phase 2 meeting with the FDA, a
sponsor may make a written request for a special protocol assessment, or SPA, of the Phase 3 clinical protocol that is intended to form the primary basis of the efficacy claim in the NDA. If the FDA and the sponsor reach agreement about
protocol design, primary efficacy endpoints, study conduct, data analysis and the kind of labeling statements one could expect in the data are supportive and the product is approved, the SPA will be documented. The agreed-to SPA will be binding on
the FDA unless the sponsor fails to follow the protocol that was agreed upon, the data and other information provided by the sponsor are found to be false, misleading or incomplete, or substantial scientific issues are identified after the testing
has begun.

Concurrent with clinical trials, companies usually complete additional animal studies and must also develop
additional information about the chemistry and physical characteristics of the drug and finalize a process for manufacturing the product in accordance with cGMP requirements. The manufacturing process must be capable of consistently producing
quality batches of the drug candidate and the manufacturer must develop methods for testing the quality, purity and potency of the final drugs. Additionally, appropriate packaging must be selected and tested and stability studies must be conducted
to demonstrate that the drug candidate does not undergo unacceptable deterioration over its shelf-life.

The results of
product development, preclinical studies and clinical studies, along with descriptions of the manufacturing process, analytical tests conducted on the chemistry of the drug, results of chemical studies and other relevant information are submitted to
the FDA as part of an NDA. The submission of an NDA is subject to the payment of user fees, but a waiver of such fees may be obtained under specified circumstances. The FDA reviews all NDAs submitted before it accepts them for filing. It may request
additional information before it will accept an NDA for filing. In this event, the NDA must be resubmitted with the additional information. The resubmitted application also is subject to review before the FDA accepts it for filing.

After the NDA is filed, the FDA will begin an in-depth review. The FDA may refer the NDA to an advisory committee for review, evaluation
and recommendation as to whether the application should be approved and under what conditions. The FDA is not bound by the recommendation of an advisory committee, but it generally follows such recommendations. The FDA may refuse to approve an NDA
if the applicable regulatory criteria are not satisfied or may require additional clinical or other data. Even if such data are submitted, the FDA may ultimately decide that the NDA does not satisfy the criteria for approval. The FDA reviews an NDA
to determine, among other things, whether a product is safe and effective for its intended use and whether its manufacturing is cGMP-compliant to assure and preserve the products identity, strength, quality and purity. Before approving an NDA,
the FDA will inspect the facility or facilities where the product is manufactured and tested.

Satisfaction of FDA
requirements typically takes several years and the actual time required may vary substantially, based upon, among other things, the indication and the type, complexity and novelty of the product. Government regulation may delay or prevent marketing
of potential products for a considerable period of time and impose costly procedures upon our activities. Success in early stage clinical trials does not assure success in later stage clinical trials. Data obtained from clinical activities are not
always conclusive and may be susceptible to varying interpretations, which could delay, limit or prevent regulatory approval. The FDA may not grant approval on a timely basis, or at all. Even if a product receives regulatory approval, the approval
may be significantly limited to specific diseases and dosages or the indications for use may otherwise be limited, which could restrict the commercial application of the product. Further, even after regulatory approval is obtained, later discovery
of previously unknown problems with a product may result in restrictions on the product or even complete withdrawal of the product from the market. Delays in obtaining, or failures to obtain, regulatory approvals for any drug candidate could
substantially harm our business and cause our stock price to drop significantly. In addition, we cannot predict what adverse governmental regulations may arise from future U.S. or foreign governmental action.



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Expedited Review and Approval

The FDA has various programs, including Fast Track, priority review, and accelerated approval, which are intended to expedite or simplify
the process for reviewing drugs, and/or provide for approval on the basis of surrogate endpoints. Generally, drugs that may be eligible for these programs are those for serious or life-threatening conditions, those with the potential to address
unmet medical needs, and those that offer meaningful benefits over existing treatments. Fast Track designation applies to the combination of the product and the specific indication for which it is being studied. Although Fast Track and priority
review do not affect the standards for approval, the FDA will attempt to facilitate early and frequent meetings with a sponsor of a Fast Track designated drug and expedite review of the application for a drug designated for priority review. Drugs
that receive an accelerated approval may be approved on the basis of adequate and well-controlled clinical trials establishing that the drug product has an effect on a surrogate endpoint that is reasonably likely to predict clinical benefit or on
the basis of an effect on a clinical endpoint other than survival or irreversible morbidity. As a condition of approval, the FDA may require that a sponsor of a drug receiving accelerated approval perform post-marketing clinical trials.

Patent Term Restoration and Marketing Exclusivity

Depending upon the timing, duration and specifics of FDA approval of the use of our drugs, some of our U.S. patents may be eligible for
limited patent term extension under the Drug Price Competition and Patent Term Restoration Act of 1984, referred to as the Hatch-Waxman Amendments. The Hatch-Waxman Amendments permit a patent restoration term of up to five years as compensation for
patent term lost during product development and the FDA regulatory review process. However, patent term restoration cannot extend the remaining term of a patent beyond a total of 14 years from the products approval date. The patent term
restoration period is generally one-half the time between the effective date of an IND, and the submission date of an NDA, plus the time between the submission date of an NDA and the approval of that application. Only one patent applicable to an
approved drug is eligible for the extension and the extension must be applied for prior to expiration of the patent. The United States Patent and Trademark Office, in consultation with the FDA, reviews and approves the application for any patent
term extension or restoration. In the future, we intend to apply for restorations of patent term for some of our currently owned or licensed patents to add patent life beyond their current expiration date, depending on the expected length of
clinical trials and other factors involved in the submission of the relevant NDA.

Market exclusivity provisions under the
FDCA also can delay the submission or the approval of certain applications. The FDCA provides a five-year period of non-patent marketing exclusivity within the United States to the first applicant to gain approval of an NDA for a new chemical
entity. A drug is a new chemical entity if the FDA has not previously approved any other new drug containing the same active moiety, which is the molecule or ion responsible for the action of the drug substance. During the exclusivity period, the
FDA may not accept for review an abbreviated new drug application, or ANDA, or a 505(b)(2) NDA submitted by another company for another version of such drug where the applicant does not own or have a legal right of reference to the data required for
approval. However, an application may be submitted after four years if it contains a certification of patent invalidity or non-infringement. The FDCA also provides three years of marketing exclusivity for an NDA, 505(b)(2) NDA or supplement to an
existing NDA if new clinical investigations, other than bioavailability studies, that were conducted or sponsored by the applicant are deemed by the FDA to be essential to the approval of the application, for example, for new indications, dosages,
or strengths of an existing drug. This three-year exclusivity covers only the conditions associated with the new clinical investigations and does not prohibit the FDA from approving ANDAs for drugs containing the original active agent. Five-year and
three-year exclusivity will not delay the submission or approval of a full NDA; however, an applicant submitting a full NDA would be required to conduct or obtain a right of reference to all of the preclinical studies and adequate and
well-controlled clinical trials necessary to demonstrate safety and effectiveness.



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Orphan Drug Designation

Under the Orphan Drug Act, the FDA may grant orphan drug designation to drugs intended to treat a rare disease or condition, which is
generally a disease or condition that affects fewer than 200,000 individuals in the United States, or more than 200,000 individuals in the United States and for which there is no reasonable expectation that the cost of developing and making
available in the United States a drug for this type of disease or condition will be recovered from sales in the United States for that drug. Orphan drug designation must be requested before submitting an NDA. After the FDA grants orphan drug
designation, the identity of the therapeutic agent and its potential orphan use are disclosed publicly by the FDA. Orphan drug designation does not convey any advantage in or shorten the duration of the regulatory review and approval process.

If a product that has orphan drug designation subsequently receives the first FDA approval for the disease for which it has
such designation, the product is entitled to orphan product exclusivity, which means that the FDA may not approve any other applications to market the same drug for the same indication, except in very limited circumstances, for seven years. Orphan
drug exclusivity, however, also could block the approval of one of our products for seven years if a competitor obtains approval of the same drug as defined by the FDA or if our drug candidate is determined to be contained within the
competitors product for the same indication or disease.

Pediatric Exclusivity

Section 505A of the FDCA, as amended by the FDA Amendments Act of 2007, permits certain drugs to obtain an additional six months of
exclusivity, if the sponsor submits information requested in writing by the FDA, or a Written Request, relating to the use of the drug in children. The FDA may not issue a Written Request for studies on unapproved or approved indications or where it
determines that information relating to the use of a drug in a pediatric population, or part of the pediatric population, may not produce health benefits in that population.

We have not requested or received a Written Request for such pediatric studies, although we may ask the FDA to issue a Written Request
for such studies in the future. To receive the six-month pediatric market exclusivity, we would have to receive a Written Request from the FDA, conduct the requested studies in accordance with a written agreement with the FDA or, if there is no
written agreement, in accordance with commonly accepted scientific principles, and submit reports of the studies. The FDA will accept the reports upon its determination that the studies were conducted in accordance with and are responsive to the
original Written Request or commonly accepted scientific principles, as appropriate, and that the reports comply with the FDAs filing requirements. The FDA may not issue a Written Request for such studies or accept the reports of the studies.

Post-approval Requirements

Once an approval is granted, the FDA may withdraw the approval if compliance with regulatory standards is not maintained or if problems
occur after the product reaches the market. After approval, some types of changes to the approved product, such as adding new indications, manufacturing changes and additional labeling claims, are subject to further FDA review and approval. In
addition, the FDA may require testing and surveillance programs to monitor the effect of approved products that have been commercialized, and the FDA has the power to prevent or limit further marketing of a product based on the results of these
post-marketing programs.

Any drug products manufactured or distributed by us pursuant to FDA approvals are subject to
continuing regulation by the FDA, including, among other things:



| |  |  | record-keeping requirements;
| | - |  | ----------------------------



| |  |  | reporting of adverse experiences with the drug;
| | - |  | -----------------------------------------------



| |  |  | providing the FDA with updated safety and efficacy information;
| | - |  | ---------------------------------------------------------------



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| |  |  | drug sampling and distribution requirements;
| | - |  | --------------------------------------------



| |  |  | notifying the FDA and gaining its approval of specified manufacturing or labeling changes;
| | - |  | ------------------------------------------------------------------------------------------



| |  |  | complying with certain electronic records and signature requirements; and
| | - |  | -------------------------------------------------------------------------



| |  |  | complying with FDA promotion and advertising requirements.
| | - |  | ----------------------------------------------------------

Drug manufacturers and their subcontractors are required to register their establishments with the FDA and some state agencies, and are
subject to periodic unannounced inspections by the FDA and some state agencies for compliance with cGMP and other laws.

We
rely, and expect to continue to rely, on third parties for the production of clinical and commercial quantities of our products. Future FDA and state inspections may identify compliance issues at the facilities of our contract manufacturers that may
disrupt production or distribution, or require substantial resources to correct.

From time to time, legislation is drafted,
introduced and passed in Congress that could significantly change the statutory provisions governing the approval, manufacturing and marketing of products regulated by the FDA. For example, on September 27, 2007, the Food and Drug
Administration Amendments Act of 2007, or FDAAA, gave the FDA enhanced postmarket authority, including the authority to require postmarket studies and clinical trials, labeling changes based on new safety information, and compliance with a risk
evaluation and mitigation strategy approved by the FDA. Failure to comply with any requirements under the new law may result in significant penalties. The new law also authorizes significant civil money penalties for the dissemination of false or
misleading direct-to-consumer advertisements. Additionally, the new law expands the clinical trial registry so that sponsors of all clinical trials, except for Phase I trials, are required to submit certain clinical trial information for
inclusion in the clinical trial registry data bank, including summary adverse effect information. In addition, FDA regulations and guidance are often revised or reinterpreted by the agency in ways that may significantly affect our business and our
products. It is impossible to predict whether further legislative changes will be enacted, or FDA regulations, guidance or interpretations changed or what the impact of such changes, if any, may be.

Foreign Regulation

In addition to regulations in the United States, we will be subject to a variety of foreign regulations governing clinical trials and
commercial sales and distribution of our products. Whether or not we obtain FDA approval for a product, we must obtain approval by the comparable regulatory authorities of foreign countries before we can commence clinical trials or marketing of the
product in those countries. The approval process varies from country to country and the time may be longer or shorter than that required for FDA approval. The requirements governing the conduct of clinical trials, product licensing, pricing and
reimbursement vary greatly from country to country.

Under European Union regulatory systems, we may submit marketing
authorization applications either under a centralized or decentralized procedure. The centralized procedure, which is compulsory for medicines produced by certain biotechnological processes, orphan drugs and products containing a new active
substance intended for treatment of specific conditions or illnesses including cancer, provides for the grant of a single marketing authorization that is valid for all European Union member states. If a drug does not fall within a mandatory
category, it may still be submitted to the centralized procedure if it contains a new active substance and constitutes a significant therapeutic, scientific or technical innovation. Other new drugs without approval in any member state will follow
the decentralized procedure which provides for approval by one or more other, or concerned, member states of an assessment of an application performed by one member state, known as the reference member state. Under this procedure, an applicant
submits an application or dossier and related material to the reference member state and concerned member states. The reference member state prepares a draft assessment and summary of the related materials within 120 days after receipt of a valid
application. Within 90 days of receiving the reference member states assessment report, each concerned member state must decide



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whether to approve the assessment report and related materials. If a member state cannot approve the assessment report and related materials on the grounds of potential serious risk to public
health, the disputed points may eventually be referred to the European Commission whose decision is binding on all member states.

As in the United States, we may apply for designation of a product as an orphan drug for the treatment of a specific indication in the
European Union before the application for marketing authorization is made. Orphan drugs in Europe enjoy economic and marketing benefits, including up to ten years of market exclusivity for the approved indication unless another applicant can
show that its product is safer, more effective or otherwise clinically superior to the orphan-designated product.

Reimbursement

Sales of pharmaceutical products depend in significant part on the availability of third-party reimbursement.
Third-party payors include government health administrative authorities, managed care providers, private health insurers and other organizations. We anticipate third-party payors will provide reimbursement for our products. However, these
third-party payors are increasingly challenging the price and examining the cost-effectiveness of medical products and services. In addition, significant uncertainty exists as to the reimbursement status of newly approved healthcare products. We may
need to conduct expensive pharmacoeconomic studies in order to demonstrate the cost-effectiveness of our products. Our drug candidates may not be considered cost-effective. It is time consuming and expensive for us to seek reimbursement from
third-party payors. Reimbursement may not be available or sufficient to allow us to sell our products on a competitive and profitable basis.

The passage of the Medicare Prescription Drug, Improvement, and Modernization Act of 2003, or the MMA, imposes new requirements for the
distribution and pricing of prescription drugs for Medicare beneficiaries, and includes a major expansion of the prescription drug benefit under a new Medicare Part D. Under Part D, Medicare beneficiaries may enroll in prescription drug plans
offered by private entities which will provide coverage of outpatient prescription drugs. Part D plans include both stand-alone prescription drug benefit plans and prescription drug coverage as a supplement to Medicare Advantage plans.
Unlike Medicare Part A and B, Part D coverage is not standardized. Part D prescription drug plan sponsors are not required to pay for all covered Part D drugs, and each drug plan can develop its own drug formulary that identifies
which drugs it will cover and at what tier or level. However, Part D prescription drug formularies must include drugs within each therapeutic category and class of covered Part D drugs, though not necessarily all the drugs in each category
or class. Any formulary used by a Part D prescription drug plan must be developed and reviewed by a pharmacy and therapeutic committee.

It is not clear what effect the MMA will have on the prices paid for currently approved drugs and the pricing options for future approved
drugs. Government payment for some of the costs of prescription drugs may increase demand for products for which we receive marketing approval. However, any negotiated prices for our products covered by a Part D prescription drug plan will
likely be lower than the prices we might otherwise obtain. Moreover, while the MMA applies only to drug benefits for Medicare beneficiaries, private payors often follow Medicare coverage policy and payment limitations in setting their own payment
rates. Any reduction in payment that results from the MMA may result in a similar reduction in payments from non-governmental payors.

On February 17, 2009, President Obama signed into law the American Recovery and Reinvestment Act of 2009. This law provides funding
for the federal government to compare the effectiveness of different treatments for the same illness. A plan for the research will be developed by the Department of Health and Human Services, the Agency for Healthcare Research and Quality and the
National Institutes for Health, and periodic reports on the status of the research and related expenditures will be made to Congress. Although the results of the comparative effectiveness studies are not intended to mandate any policies for public
or private payors, it is not clear what if any effect the research will have on the sales of our drug candidates if any such drug candidate or the condition that it is intended to treat is the subject of a study. Decreases in third-party
reimbursement for our drug candidates or a decision by a third-party payor to not cover our drug candidates could reduce physician usage of the drug candidate and have a material adverse effect on our sales, results of operations and financial
condition.



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We expect that there will continue to be a number of federal and state proposals to
implement governmental pricing controls and limit the growth of healthcare costs, including the cost of prescription drugs. For example, in March 2010, President Obama signed one of the most significant health care reform measures in decades, the
Patient Protection and Affordable Care Act, as amended by the Health Care and Education Affordability Reconciliation Act, collectively referred to as the PPACA. The PPACA will significantly impact the pharmaceutical industry. The PPACA will require
discounts under the Medicare drug benefit program and increased rebates on drugs covered by Medicaid. In addition, the PPACA imposes an annual fee, which will increase annually, on sales by branded pharmaceutical manufacturers starting in 2011. The
financial impact of these discounts, increased rebates and fees and the other provisions of the PPACA on our business is unclear.

In addition, in some foreign countries, the proposed pricing for a drug must be approved before it may be lawfully marketed. The
requirements governing drug pricing vary widely from country to country. For example, the European Union provides options for its member states to restrict the range of medicinal products for which their national health insurance systems provide
reimbursement and to control the prices of medicinal products for human use. A member state may approve a specific price for the medicinal product or it may instead adopt a system of direct or indirect controls on the profitability of the company
placing the medicinal product on the market. There can be no assurance that any country that has price controls or reimbursement limitations for pharmaceutical products will allow favorable reimbursement and pricing arrangements for any of our drug
candidates.

Employees

As of June 30, 2010, we had 152 full-time employees, 50 of whom hold an M.D., Ph.D, or combined M.D./Ph.D. Approximately 126
employees are engaged in research and development and clinical and regulatory affairs, and 26 are in general and administrative functions. Our workforce is non-unionized, and we believe our employee relations are good.

Corporate History and Available Information

We were incorporated as Myriad Pharmaceuticals, Inc. in Delaware in January 2009 as a new, wholly owned subsidiary of Myriad Genetics,
Inc. in order to effect the separation and spin-off of Myriad Genetics research and drug development businesses as a stand-alone, independent, publicly traded company. In connection with the formation of this new subsidiary, Myriad
Genetics existing subsidiary, Myriad Pharmaceuticals, Inc., changed its corporate name to Myriad Therapeutics, Inc. On June 30, 2009, Myriad Genetics contributed substantially all of the assets and certain liabilities of its research and
drug development businesses as well as $188 million in cash and marketable securities to us and effected the spin-off of our company through the pro rata dividend distribution to its stockholders of all outstanding shares of our common stock.
Effective July 1, 2010, we changed our name from Myriad Pharmaceuticals, Inc. to Myrexis, Inc. Our principal executive offices are located at 305 Chipeta Way, Salt Lake City, Utah 84108. Our telephone number is 801-214-7800 and our web site
address is www.myrexis.com. We include our web site address in this Annual Report on Form 10-K only as an inactive textual reference and do not intend it to be an active link to our web site. We make available free of charge through the
Investors section of our web site our Corporate Code of Conduct and Ethics, our Audit Committee and other committee charters and our other corporate governance policies, as well as our Annual Reports on Form 10-K, Quarterly Reports on
Form 10-Q, current reports on Form 8-K and all amendments to those reports as soon as reasonably practicable after such material is electronically filed with or furnished to the Securities and Exchange Commission (SEC).



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|Item 1A. | RISK FACTORS
|-------- | ------------

The
risks and uncertainties described below are those that we currently believe may materially affect our company. If any of the following risks actually occur, they may materially harm our business, our financial condition and our results of
operations.

Risks Relating to Our Financial Position and Our Business

We anticipate that we will incur losses for the foreseeable future and we may never achieve or sustain profitability.

We do not expect to generate the cash that is necessary to finance our operations in the short term. We incurred losses of $46.9 million,
$58.1 million and $34.4 million for the years ended June 30, 2010, 2009 and 2008, respectively. We expect to continue to incur significant research and development and other significant operating expenses and capital expenditures and anticipate
that our expenses and losses will increase substantially in the foreseeable future as we:



| |  |  | conduct our ongoing and planned clinical trials for Azixa and MPC-3100 and initiate additional clinical trials, if supported by the results of our
ongoing trials;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | complete preclinical development of MPC-9528, MPI-485520, MPI-487109 and MPI-443803 and initiate clinical trials, if supported by positive preclinical
data;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | identify additional drug candidates and acquire rights from third parties to drug candidates through licenses, acquisitions or other means;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | commercialize any approved drug candidates;
| | - |  | -------------------------------------------



| |  |  | begin to establish commercial manufacturing arrangements and establish sales and marketing functions;
| | - |  | -----------------------------------------------------------------------------------------------------



| |  |  | hire additional clinical, scientific, manufacturing/quality and management personnel; and
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | add operational, financial and management information systems and personnel.
| | - |  | ----------------------------------------------------------------------------

We must generate significant revenue to achieve and maintain profitability. Even if we succeed in developing and commercializing one or
more of our drug candidates, we may not be able to generate sufficient revenue and we may never be able to achieve or maintain profitability.

We will require additional capital to fund our operations, and if we are unable to obtain such capital, we will be unable to successfully develop
and commercialize our drug candidates.

We believe that our existing cash and investment securities will be sufficient
to support our current operating plan through at least June 30, 2013. However, we will require additional capital in order to complete the clinical development of and to commercialize our drug candidates. Our future capital requirements will
depend on many factors that are currently unknown to us, including:



| |  |  | the timing of initiation, progress, results and costs of our clinical trials for Azixa and MPC-3100;
| | - |  | ----------------------------------------------------------------------------------------------------



| |  |  | the results of preclinical studies of MPC-9528, MPI-485520, MPI-487109 and MPI-443803, and the timing of initiation, progress, results and costs of any
clinical trials that we may initiate based on the preclinical results;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs of establishing commercial manufacturing arrangements and of establishing sales and marketing functions;
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | the scope, progress, results, and cost of preclinical development, clinical trials, and regulatory review of any new drug candidates for which we may
initiate development;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | the costs of preparing, filing, and prosecuting patent applications and maintaining, enforcing, and defending intellectual property-related claims;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our ability to establish research collaborations and strategic collaborations and licensing or other arrangements on terms favorable to us;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs to satisfy our obligations under potential future collaborations; and
| | - |  | -------------------------------------------------------------------------------



| |  |  | the timing, receipt, and amount of sales or royalties, if any, from any approved drug candidates.
| | - |  | -------------------------------------------------------------------------------------------------

There can be no assurance that additional funds will be available when we need them on terms that are acceptable to us, or at all. If
adequate funds are not available on a timely basis, we may be required to:



| |  |  | terminate or delay clinical trials or other development for one or more of our drug candidates;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | delay our establishment of sales and marketing capabilities, commercial manufacturing capabilities, or other activities that may be necessary to
commercialize our drug candidates; or
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | curtail significant drug development programs that are designed to identify new drug candidates.
| | - |  | ------------------------------------------------------------------------------------------------

We may seek to raise any necessary funds through public or private equity offerings, debt financings or strategic alliances and licensing
arrangements. We may not be able to obtain additional financing on terms favorable to us, if at all. General market conditions may make it very difficult for us to seek financing from the capital markets. We may be required to relinquish rights to
our technologies or drug candidates, or grant licenses on terms that are not favorable to us, in order to raise additional funds through alliance, joint venture or licensing arrangements.

Our future success depends on our ability to retain our chief executive officer and other key executives and to attract, retain, and motivate
qualified personnel.

The competition for qualified personnel in the biotechnology field is intense and we must retain
and motivate highly qualified scientific personnel. We are highly dependent on Dr. Adrian Hobden, our President and Chief Executive Officer, Wayne Laslie, our Chief Operating Officer, and Robert Lollini, our Chief Financial Officer. There can
be no assurance that we will be able to retain any of our key executives due in part to the fact that the agreements we have entered into with the principal members of our executive and scientific teams provide for employment that can be terminated
by either party without cause at any time. Further, the non-compete provisions to which each employee is subject, generally expire for certain key executive officers one year from the applicable date of termination of employment, which means that
these executives may be employed by a competitor of ours in the future. We have entered into retention agreements with certain of our key executive officers to reinforce and encourage continued employment and dedication without distraction from the
possibility of a change in control and related events and circumstances. Although we do not have any reason to believe that we may lose the services of any of these persons in the foreseeable future, the loss of the services of any of these persons
might impede the achievement of our research, development, and commercialization objectives. Recruiting and retaining qualified scientific personnel and possibly sales and marketing personnel will also be critical to our success. We may not be able
to attract and retain these personnel on acceptable terms given the competition among numerous pharmaceutical and biotechnology companies for similar personnel. We also experience competition for the hiring of scientific personnel from universities
and research institutions. In addition, we rely on consultants and advisors, including scientific and clinical advisors, to assist us in formulating our research and development and commercialization strategy. Our consultants and advisors may be
employed by employers other than us and may have commitments under consulting or advisory contracts with other entities that may limit their availability to us.



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Risks Related to the Development and Regulatory Approval of Our Drug Candidates

Our success is largely dependent on the success of our drug candidates, and we cannot be certain that we will be able to obtain
regulatory approval for or successfully commercialize any of these drug candidates.

We have invested a significant
portion of our time and financial resources in the development of our clinical-stage drug candidates Azixa and MPC-3100. We anticipate that our success will depend largely on the receipt of regulatory approval and successful commercialization of
these drug candidates. The future success of these drug candidates will depend on several factors, including the following:



| |  |  | our ability to provide acceptable evidence of their safety and efficacy;
| | - |  | ------------------------------------------------------------------------



| |  |  | receipt of marketing approval from the FDA and similar foreign regulatory authorities;
| | - |  | --------------------------------------------------------------------------------------



| |  |  | obtaining and maintaining commercial manufacturing arrangements with third-party manufacturers or establishing commercial-scale manufacturing
capabilities;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | establishing an internal sales force or collaborating with pharmaceutical companies or contract sales organizations to market and sell any approved
drug; and
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | acceptance of any approved drug in the medical community and by patients and third-party payors.
| | - |  | ------------------------------------------------------------------------------------------------

Many of these factors are beyond our control. Accordingly, we cannot assure you that we will ever be able to generate revenues through
the license or sale of Azixa, MPC-3100 or our other drug candidates.

Our drug candidates are still in the early stages of development
and remain subject to clinical testing and regulatory approval. If we are unable to successfully develop and test our drug candidates, we will not be successful.

To date, we have not marketed, distributed or sold any drugs. The success of our business depends substantially upon our ability to
develop and commercialize our drug candidates successfully. We have two clinical-stage drug candidates currently in development, Azixa, and MPC-3100, both of which are in the early stages of development. Our drug candidates are prone to the risks of
failure inherent in drug development. Before obtaining regulatory approvals for the commercial sale of Azixa, MPC-3100 or any other drug candidate for a target indication, we must demonstrate with substantial evidence gathered in well-controlled
clinical trials, and, with respect to approval in the United States, to the satisfaction of the FDA and, with respect to approval in other countries, similar regulatory authorities in those countries, that the drug candidate is safe and effective
for use for that target indication. Satisfaction of these and other regulatory requirements is costly, time consuming, uncertain, and subject to unanticipated delays. Despite our efforts, our drug candidates may not:



| |  |  | offer improvement over existing, comparable drugs;
| | - |  | --------------------------------------------------



| |  |  | be proven safe and effective in clinical trials;
| | - |  | ------------------------------------------------



| |  |  | meet applicable regulatory standards; or
| | - |  | ----------------------------------------



| |  |  | be successfully commercialized.
| | - |  | -------------------------------

Positive results in preclinical studies of a drug candidate may not be predictive of similar results in humans during clinical trials,
and promising results from early clinical trials of a drug candidate may not be replicated in later clinical trials. Interim results of a clinical trial do not necessarily predict final results. A number of companies in the pharmaceutical and
biotechnology industries have suffered significant setbacks in late-stage clinical trials even after achieving promising results in early-stage development. Accordingly, the results from completed preclinical studies and clinical trials for our drug
candidates may not be predictive of the results we may obtain in later stage trials or studies. Our preclinical studies or clinical trials may produce negative or inconclusive results, and we may decide, or regulators may require us, to conduct
additional preclinical studies or clinical trials, or to discontinue clinical trials altogether. We do not expect any of our drug candidates to be commercially available for at least several years and some or all may never become commercially
available.



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If clinical trials for our drug candidates are prolonged or delayed, we may be unable to commercialize
our drug candidates on a timely basis, which would require us to incur additional costs and delay our receipt of any revenue from potential product sales.

We cannot predict whether we will encounter problems with any of our ongoing or planned clinical trials that will cause us or any
regulatory authority to delay or suspend those clinical trials or delay the analysis of data derived from them. A number of events, including any of the following, could delay the completion of our ongoing and planned clinical trials and negatively
impact our ability to obtain regulatory approval for, and to market and sell, a particular drug candidate:



| |  |  | conditions imposed on us by the FDA or any foreign regulatory authority regarding the scope or design of our clinical trials;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------



| |  |  | delays in obtaining, or our inability to obtain, required approvals from institutional review boards, or IRBs, or other reviewing entities at clinical
sites selected for participation in our clinical trials;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | insufficient supply or deficient quality of our drug supply or other materials necessary to conduct our clinical trials;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | delays in obtaining regulatory agency agreement for the conduct of our clinical trials;
| | - |  | ---------------------------------------------------------------------------------------



| |  |  | lower than anticipated enrollment and retention rate of subjects in clinical trials for a variety of reasons, including size of patient population,
nature of trial protocol, the availability of approved effective treatments for the relevant disease and competition from other clinical trial programs for similar indications;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | serious and unexpected drug-related side effects experienced by patients in clinical trials; or
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | failure of our third-party contractors to meet their contractual obligations to us in a timely manner.
| | - |  | ------------------------------------------------------------------------------------------------------

Clinical trials may also be delayed or terminated as a result of ambiguous or negative interim results. In addition, a clinical trial may
be suspended or terminated by us, the FDA, the IRBs at the sites where the IRBs are overseeing a trial, or other regulatory authorities due to a number of factors, including:



| |  |  | failure to conduct the clinical trial in accordance with regulatory requirements or our clinical protocols;
| | - |  | -----------------------------------------------------------------------------------------------------------



| |  |  | the imposition of a clinical hold by the FDA;
| | - |  | ---------------------------------------------



| |  |  | varying interpretation of data by the FDA or similar foreign regulatory authorities;
| | - |  | ------------------------------------------------------------------------------------



| |  |  | failure to achieve primary or secondary endpoints or other failure to demonstrate efficacy;
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | unforeseen safety issues; or
| | - |  | ----------------------------



| |  |  | lack of adequate funding to continue the clinical trial.
| | - |  | --------------------------------------------------------

Additionally, changes in standard of care or regulatory requirements and guidance may occur and we may need to amend clinical trial
protocols to reflect these changes. Such amendments may require us to resubmit our clinical trial protocols to IRBs for reexamination, which may impact the cost, timing or successful completion of a clinical trial.

We do not know whether our clinical trials will begin as planned, will need to be restructured or will be completed on schedule, if at
all. Delays in our clinical trials will result in increased development costs for our drug candidates. In addition, if we experience delays in completion of, or if we terminate, any of our clinical trials, the commercial prospects for our drug
candidates may be affected and our ability to generate product revenues will be delayed. Furthermore, many of the factors that cause, or lead to, a delay in the commencement or completion of clinical trials may also ultimately lead to the denial of
regulatory approval of a drug candidate.



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Even if our drug candidates receive regulatory approval in the United States, we may never receive
approval or commercialize our products outside of the United States.

In order to market any products outside of the
United States, we must establish and comply with numerous and varying regulatory requirements of other countries regarding safety and efficacy. Approval procedures vary among countries and can involve additional product testing and additional
administrative review periods. The time required to obtain approval in other countries might differ from that required to obtain FDA approval. The regulatory approval process in other countries may include all of the risks detailed above regarding
FDA approval in the United States as well as other risks. Regulatory approval in one country does not ensure regulatory approval in another, but a failure or delay in obtaining regulatory approval in one country may have a negative effect on the
regulatory process in others. Failure to obtain regulatory approval in other countries or any delay or setback in obtaining such approval would impair our ability to develop foreign markets for our drug candidates and may have a material adverse
effect on our results of operations and financial condition.

Both before and after marketing approval, our drug candidates are subject
to ongoing regulatory requirements, and if we fail to comply with these continuing requirements, we could be subject to a variety of sanctions and the sale of any approved commercial products could be suspended.

Both before and after regulatory approval to market a particular drug candidate, the manufacturing, labeling, packaging, adverse event
reporting, storage, advertising, promotion and record keeping related to the drug are subject to extensive regulatory requirements. If we fail to comply with the regulatory requirements of the FDA and other applicable U.S. and foreign regulatory
authorities, we could be subject to administrative or judicially imposed sanctions, including:



| |  |  | restrictions on the products or manufacturing processes;
| | - |  | --------------------------------------------------------



| |  |  | warning letters;
| | - |  | ----------------



| |  |  | civil or criminal penalties;
| | - |  | ----------------------------



| |  |  | fines;
| | - |  | ------



| |  |  | injunctions;
| | - |  | ------------



| |  |  | product seizures or detentions;
| | - |  | -------------------------------



| |  |  | voluntary or mandatory product recalls and related publicity requirements;
| | - |  | --------------------------------------------------------------------------



| |  |  | suspension or withdrawal of regulatory approvals;
| | - |  | -------------------------------------------------



| |  |  | total or partial suspension of production; and
| | - |  | ----------------------------------------------



| |  |  | refusal to approve pending applications for marketing approval of new products or supplements to approved applications.
| | - |  | -----------------------------------------------------------------------------------------------------------------------

If side effects increase or are identified during the time our drug candidates are in development or after they are approved and on the market, we
may be required to perform lengthy additional clinical trials, change the labeling of any such products, or withdraw such products from the market, any of which would hinder or preclude our ability to generate revenues.

In completed and ongoing clinical trials in which 163 subjects have been treated to date with Azixa, 12 serious adverse events in 11
subjects have been reported as possibly, probably or definitely related to Azixa: nonfatal myocardial infarction (single events in three subjects), cerebral hemorrhage (single events in two subjects), cerebral ischemia (one event in one subject),
troponin I increase (one event in one subject), hypersensitivity (two events in one subject), pulmonary embolism (one event in one subject), hypertension (one event in one subject), and headache (one event in one subject). To date, the overall
incidence of myocardial infarction is 1.8%, the incidence of cerebral hemorrhage is 1.2% and the incidence of cerebral ischemia, pulmonary embolism, hypertension, headache and troponin I increase is 0.6% each.



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In the second quarter of 2009, we initiated an open-label, dose-finding, multiple-dose Phase
1 clinical trial of MPC-3100, our drug candidate in development for the treatment of cancer, in up to 40 patients with refractory or relapsed cancers, including solid tumors, lymphomas and leukemias. In this ongoing study, MPC-3100 has been observed
to be orally bio-available in cancer patients. The pharmacokinetic properties and drug concentration achieved in patients to date are similar to those observed in efficacious animal studies and no dose limiting toxicities have been reported to date.
In the ongoing Phase 1 clinical trial, 17 subjects have been treated with MPC-3100. Four serious adverse events in three subjects have been reported as possibly or probably related to MPC-3100: abdominal pain (single event in a single patient),
respiratory failure and supraventricular tachycardia (two events in a single patient), and vomiting (single event in a single patient).

If the incidences of these side effects increases or other problems occur in future clinical trials, we may be required to terminate or
delay clinical development of the product candidate. Furthermore, even if any of our drug candidates receives marketing approval, as greater numbers of patients use a drug following its approval, if the incidence of side effects increases or if
other problems are observed after approval that were not seen or anticipated during pre-approval clinical trials, a number of potentially significant negative consequences could result, including:



| |  |  | regulatory authorities may withdraw their approval of the product;
| | - |  | ------------------------------------------------------------------



| |  |  | we may be required to reformulate such products, change the way the product is manufactured or administered, conduct additional clinical trials or
change the labeling of the product;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | we may become the target of lawsuits, including class action suits; and
| | - |  | -----------------------------------------------------------------------



| |  |  | our reputation in the market place may suffer resulting in a significant drop in the sales of the affected products.
| | - |  | --------------------------------------------------------------------------------------------------------------------

Any of these events could substantially increase the costs and expenses of developing, commercializing and marketing any such drug
candidates or could harm or prevent sales of any approved products.

While we choose to test our drug candidates in specific clinical
indications based in part on our understanding of their mechanisms of action, our understanding may be incorrect or incomplete and, therefore, our drugs may not be effective against the diseases tested in our clinical trials.

Our rationale for selecting the particular therapeutic indications for each of our drug candidates is based in part on our understanding
of the mechanism of action of these drug candidates. However, our understanding of the drug candidates mechanism of action may be incomplete or incorrect, or the mechanism may not be clinically relevant to the diseases treated. In such cases,
our drug candidates may prove to be ineffective in the clinical trials for treating those diseases.

We deal with hazardous materials
and must comply with environmental laws and regulations, which can be expensive and restrict how we do business.

Certain of our drug development activities involve the controlled storage, use, and disposal of hazardous materials. We are subject to
federal, state, and local laws and regulations governing the use, manufacture, storage, handling, and disposal of these hazardous materials. Although we believe that our safety procedures for the handling and disposing of these materials comply with
the standards prescribed by these laws and regulations, we cannot eliminate the risk of accidental contamination or injury from these materials. In the event of an accident, state or federal authorities may curtail our use of these materials, and we
could be liable for any civil damages that result, which may exceed our financial resources and may seriously harm our business. Because we believe that our laboratory and materials handling policies and practices sufficiently mitigate the
likelihood of materials liability or third-party claims, we currently carry no insurance covering such claims. An accident could damage, or force us to shut down, our operations.



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Risks Related to the Commercialization of Our Drug Candidates

Even if any of our drug candidates receives regulatory approval, if the approved product does not achieve broad market acceptance, the revenues
that we generate from sales of the product will be limited.

Even if drug candidates we may develop or acquire in the
future obtain regulatory approval, they may not gain broad market acceptance among physicians, healthcare payors, patients, and the medical community. The degree of market acceptance for any approved drug candidate will depend on a number of
factors, including:



| |  |  | demonstration of clinical safety and efficacy compared to other products;
| | - |  | -------------------------------------------------------------------------



| |  |  | prevalence and severity of adverse side effects;
| | - |  | ------------------------------------------------



| |  |  | availability of reimbursement from managed care plans and other third-party payors;
| | - |  | -----------------------------------------------------------------------------------



| |  |  | convenience and ease of administration;
| | - |  | ---------------------------------------



| |  |  | cost-effectiveness;
| | - |  | -------------------



| |  |  | timing of market introduction of competitive products;
| | - |  | ------------------------------------------------------



| |  |  | other potential advantages of alternative treatment methods; and
| | - |  | ----------------------------------------------------------------



| |  |  | ineffective marketing and distribution support of our products.
| | - |  | ---------------------------------------------------------------

If our approved drugs fail to achieve broad market acceptance, we may not be able to generate significant revenue and our business would
suffer.

If we are unable to establish sales and marketing capabilities or enter into agreements with third parties to market and sell
our drug candidates, we may be unable to generate product revenue.

We do not currently have an organization for the
sales, marketing and distribution of pharmaceutical products. In order to market any products that may be approved by the FDA, or similar foreign regulatory authorities, we must build our sales, marketing, managerial and other non-technical
capabilities or make arrangements with third parties to perform these services. If we are unable to establish adequate sales, marketing and distribution capabilities, whether independently or with third parties, we may not be able to generate
product revenue and our business would suffer.

If government and third-party payors fail to provide adequate coverage and payment rates
for any of our drug candidates that receive regulatory approval, our revenue and prospects for profitability will be harmed.

In both domestic and foreign markets, the sales of any future products will depend in part upon the availability of reimbursement from
third-party payors. Such third-party payors include government health programs such as Medicare, managed care providers, private health insurers, and other organizations. These third-party payors are increasingly attempting to contain healthcare
costs by demanding price discounts or rebates and limiting both coverage and the amounts that they will pay for new drugs, and, as a result, they may not cover or provide adequate payment for our drug candidates. In addition, in order to show such
payors that our future products are cost effective, we may have to conduct costly post-marketing clinical studies. Adequate third-party reimbursement might not be available to enable us to maintain price levels sufficient to realize an appropriate
return on investment in product development.

Changes in healthcare policy could adversely affect our business.

U.S. and foreign governments continue to propose and pass legislation designed to reduce the cost of healthcare. For example, the Medicare
Prescription Drug Improvement and Modernization Act of 2003, or MMA, expanded Medicare coverage for drugs purchased by Medicare beneficiaries and introduced new reimbursement methodologies. In addition, this law provided authority for limiting the
number of drugs that will be covered in any therapeutic class. We do not know what impact the MMA and similar laws will have on the



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availability of coverage for and the price that we receive for any approved products. Moreover, while the MMA applies only to drug benefits for Medicare beneficiaries, private payors often follow
Medicare policies in setting their own reimbursement policies, and any reduction in reimbursement that results from the MMA may result in similar reductions by private payors.

In March 2010, the President signed the Patient Protection and Affordable Care Act, as amended by the Health Care and Education
Affordability Reconciliation Act, or the PPACA. This law will substantially change the way health care is financed by both government health plans and private insurers, and significantly impact the pharmaceutical industry. The PPACA contains a
number of provisions that are expected to impact our business and operations in ways that may negatively affect our potential revenues in the future. For example, the PPACA imposes a non-deductible excise tax on pharmaceutical manufacturers or
importers that sell branded prescription drugs to U.S. government programs which we believe will increase the cost of our products. In addition, as part of the PPACAs provisions closing a funding gap that currently exists in the Medicare Part
D prescription drug program (commonly known as the donut hole), we will be required to provide a 50% discount on branded prescription drugs sold to beneficiaries who fall within the donut hole. While it is too early to predict all the
specific effects the PPACA or any future healthcare reform legislation will have on our business, they could have a material adverse effect on our business and financial condition.

The markets for our drug candidates are subject to intense competition. If we are unable to compete effectively, our drug candidates may be
rendered noncompetitive or obsolete.

The development and commercialization of new drugs is highly competitive. We will
face competition with respect to all drug candidates we may develop or commercialize in the future from pharmaceutical and biotechnology companies worldwide. The key factors affecting the success of any approved product will be its efficacy, safety
profile, drug interactions, method of administration, pricing, reimbursement and level of promotional activity relative to those of competing drugs. If approved, we would expect our clinical-stage drug candidates, Azixa and MPC-3100, to compete with
approved drugs and potentially with drug candidates currently under development, including the following:



| |  |  | Azixa. If approved, we would expect Azixa to compete with multiple vascular disrupting agents in clinical development (including vadimezan from
Novartis and ombrabulin from sanofi-Aventis, which are currently in Phase 3 development) as well as numerous treatments for glioblastoma in development (including cilengitide from Merck KGaA, which is currently in Phase 3 development) and approved
products, temozolomide, carmustine implants and bevacizumab. If approved for metastatic melanoma, we would expect Azixa to compete with other treatments for metastatic melanoma currently in clinical development (including ipilimumab from
Bristol-Myers Squibb and PLX4032 from Plexxikon/ Roche, which are currently in Phase 3 development) and approved products interleukin-2 and dacarbazine.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | MPC-3100. If approved, we would expect MPC-3100 to compete with natural product derived, geldanamycin-based analogs in development (including
retaspimycin from Infinity, which is in Phase 2 development) and non-geldanamycin small molecule inhibitors of Hsp90 currently in clinical development (including AUY922 from Vernalis/Novartis and STA-9090 from Synta which are in Phase 2
development), as well as other cancer treatments currently approved or in clinical development.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Furthermore, many large pharmaceutical and biotechnology companies, academic institutions, governmental agencies, and other public and
private research organizations are pursuing the development of novel drugs that target the same indications we are targeting with our drug candidates. We face, and expect to continue to face, intense and increasing competition as new products enter
the market and advanced technologies become available. Many of our competitors have:



| |  |  | significantly greater financial, technical and human resources than we have and may be better equipped to discover, develop, manufacture and
commercialize drug candidates;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | more extensive experience in preclinical testing and clinical trials, obtaining regulatory approvals and manufacturing and marketing pharmaceutical
products;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | drug candidates that have been approved or are in late-stage clinical development; and/or
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | collaborative arrangements in our target markets with leading companies and research institutions.
| | - |  | --------------------------------------------------------------------------------------------------

Competitive products may render our products obsolete or noncompetitive before we can recover the expenses of developing and
commercializing our drug candidates. Furthermore, the development of new treatment methods and/or the widespread adoption or increased utilization of any vaccine or development of other products or treatments for the diseases we are targeting could
render our drug candidates noncompetitive, obsolete or uneconomical. If we successfully develop and obtain approval for our drug candidates, we will face competition based on the safety and effectiveness of our drug candidates, the timing of their
entry into the market in relation to competitive products in development, the availability and cost of supply, marketing and sales capabilities, reimbursement coverage, price, patent position and other factors. If we successfully develop drug
candidates but those drug candidates do not achieve and maintain market acceptance, our business will not be successful.

If a
successful product liability claim or series of claims is brought against us for uninsured liabilities or in excess of insured liabilities, we could incur substantial liability.

The use of our drug candidates in clinical trials and the sale of any products for which we obtain marketing approval expose us to the
risk of product liability claims. Product liability claims might be brought against us by consumers, health care providers or others selling or otherwise coming into contact with our products. If we cannot successfully defend ourselves against
product liability claims, we could incur substantial liabilities. In addition, regardless of merit or eventual outcome, product liability claims may result in:



| |  |  | decreased demand for any approved drug candidates;
| | - |  | --------------------------------------------------



| |  |  | impairment of our business reputation;
| | - |  | --------------------------------------



| |  |  | withdrawal of clinical trial participants;
| | - |  | ------------------------------------------



| |  |  | costs of related litigation;
| | - |  | ----------------------------



| |  |  | distraction of managements attention from our primary business;
| | - |  | ----------------------------------------------------------------



| |  |  | substantial monetary awards to patients or other claimants;
| | - |  | -----------------------------------------------------------



| |  |  | loss of revenues; and
| | - |  | ---------------------



| |  |  | the inability to successfully commercialize any approved drug candidates.
| | - |  | -------------------------------------------------------------------------

We have obtained product liability insurance coverage for our clinical trials with a $5.0 million annual aggregate coverage limit.
However, our insurance coverage may not be sufficient to reimburse us for any expenses or losses we may suffer. Moreover, insurance coverage is becoming increasingly expensive, and, in the future, we may not be able to maintain insurance coverage at
a reasonable cost or in sufficient amounts to protect us against losses due to liability. If and when we obtain marketing approval for any of our drug candidates, we intend to expand our insurance coverage to include the sale of commercial products;
however, we may be unable to obtain this product liability insurance on commercially reasonable terms. On occasion, large judgments have been awarded in class action lawsuits based on drugs that had unanticipated side effects. A successful product
liability claim or series of claims brought against us could cause our stock price to decline and, if judgments exceed our insurance coverage, could decrease our cash and adversely affect our business.

We are subject to federal and state laws prohibiting kickbacks and false or fraudulent claims, and state gift ban laws which, if
violated, could subject us to substantial penalties. Additionally, any challenge to or investigation into our practices under these laws could cause adverse publicity and be costly to respond to, and thus could harm our business.

A federal law commonly known as the federal anti-kickback law, and several similar state laws, prohibit the payment of any remuneration
that is intended to induce physicians or others either to refer patients or to acquire or arrange for or recommend the acquisition of health care products or services. Other federal and state laws



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generally prohibit individuals or entities from knowingly presenting, or causing to be presented, claims for payment to Medicare, Medicaid or other third-party payors that are false or
fraudulent, or for items or services that were not provided as claimed.

A number of states have enacted laws that require
pharmaceutical and medical device companies to monitor and report payments, gifts and other remuneration made to physicians and other health care professional and health care organizations. Some state statutes, such as the one in Massachusetts,
impose an outright ban on gifts to physicians. These laws are often referred to as gift ban or aggregate spend laws, and they carry substantial fines if they are violated. In addition, the PPACA requires the annual
reporting of certain payments and other transfers of value that are made to health care professionals in 2012 and thereafter. The federal PPACA does not preempt all aspects of the similar state laws.

In the event that we are found to have violated these laws or decide to settle a claim that we have done so, our business may be
materially adversely affected as a result of any payments required to be made, restrictions on our future operations or actions required to be taken, damage to our business reputation or adverse publicity in connection with such a finding or
settlement or other adverse effects relating thereto. Additionally, even an unsuccessful challenge or investigation into our practices could cause adverse publicity, and be costly to respond to, and thus could harm our business and results of
operations.

Risks Related to Our Dependence on Third Parties

We rely on third parties to conduct our clinical trials, and those third parties may not perform satisfactorily, including failing to meet
established deadlines for the completion of such clinical trials.

We do not have the ability to independently conduct
clinical trials for our drug candidates, and we rely on third parties, such as contract research organizations, medical institutions, and clinical investigators, to perform this function. Our reliance on these third parties for clinical development
activities reduces our control over these activities. Furthermore, these third parties may also have relationships with other entities, some of which may be our competitors. Although we have, in the ordinary course of business, entered into
agreements with these third parties, we continue to be responsible for confirming that each of our clinical trials is conducted in accordance with its general investigational plan and protocol. Moreover, the FDA requires us to comply with
regulations and standards, commonly referred to as good clinical practices, for conducting, recording and reporting the results of clinical trials to assure that data and reported results are credible and accurate and that the trial participants are
adequately protected. Our reliance on third parties does not relieve us of these responsibilities and requirements. To date, we believe our contract research organizations and other similar entities with which we are working have performed well.
However, if these third parties do not successfully carry out their contractual duties or meet expected deadlines, we may be required to replace them. Although we believe that there are a number of other third-party contractors we could engage to
continue these activities, it may result in a delay of the affected trial. Accordingly, we may be delayed in obtaining regulatory approvals for our drug candidates and may be delayed in our efforts to successfully commercialize our drug candidates
for targeted diseases.

If we do not establish strategic collaborations, we may have to alter our development plans.

Our drug development programs and potential commercialization of our drug candidates will require substantial additional cash to fund
expenses. Our strategy includes collaborating with leading pharmaceutical and biotechnology companies to assist us in furthering development and potential commercialization of some of our drug candidates, in some or all geographies. It may be
difficult to enter into one or more of such collaborations in the future. We face significant competition in seeking appropriate collaborators and these collaborations are complex and time-consuming to negotiate and document. We may not be able to
negotiate collaborations on acceptable terms, or at all. If that were to occur, we may have to curtail the development of a particular drug candidate, reduce or delay its development program or one or more of our other development programs, delay
its potential commercialization or reduce the scope of our sales or marketing activities, or increase our expenditures



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and undertake development or commercialization activities at our own expense. If we elect to increase our expenditures to fund development or commercialization activities on our own, we may need
to obtain additional capital, which may not be available to us on acceptable terms, or at all. If we do not have sufficient funds, we will not be able to bring our drug candidates to market and generate product revenue.

We have no manufacturing capacity and depend on third-party manufacturers to produce our clinical trial drug supplies.

We do not currently operate manufacturing facilities for clinical or commercial production of any of our drug candidates. We have limited
experience in drug manufacturing, and we lack the resources and the capabilities to manufacture any of our drug candidates on a clinical or commercial scale. As a result, we currently rely on third-party manufacturers to supply, store, and
distribute drug supplies for our clinical trials and anticipate future reliance on a limited number of third-party manufacturers until we increase the number of manufacturers with whom we contract. Any performance failure on the part of our existing
or future manufacturers could delay clinical development or regulatory approval of our drug candidates or commercialization of any approved products, producing additional losses and depriving us of potential product revenue.

Our drug candidates require precise, high quality manufacturing. Failure by our contract manufacturers to achieve and maintain high
manufacturing standards could result in patient injury or death, product recalls or withdrawals, delays or failures in testing or delivery, cost overruns, or other problems that could seriously hurt our business. Contract manufacturers may encounter
difficulties involving production yields, quality control, and quality assurance. These manufacturers are subject to ongoing periodic unannounced inspection by the FDA and corresponding state and foreign agencies to ensure strict compliance with
cGMP, and other applicable government regulations and corresponding foreign standards; however, we do not have control over third-party manufacturers compliance with these regulations and standards.

If for some reason our contract manufacturers cannot perform as agreed, we may be required to replace them. Although we believe there are
a number of potential replacements as our manufacturing processes are not manufacturer specific, we may incur added costs and delays in identifying and qualifying any such replacements because the FDA must approve any replacement manufacturer prior
to manufacturing our drug candidates. Such approval would require new testing and compliance inspections. In addition, a new manufacturer would have to be educated in, or develop substantially equivalent processes for, production of our drug
candidates after receipt of FDA approval.

We anticipate continued reliance on third-party manufacturers if we are successful in
obtaining marketing approval from the FDA and other regulatory agencies for any of our drug candidates.

To date, our
drug candidates have been manufactured in small quantities for preclinical testing and clinical trials by third-party manufacturers. If the FDA or other regulatory agencies approve any of our drug candidates for commercial sale, we expect that we
would continue to rely, at least initially, on third-party manufacturers to produce commercial quantities of our approved drug candidates. These manufacturers may not be able to successfully increase the manufacturing capacity for any of our
approved drug candidates in a timely or economic manner, or at all. Significant scale-up of manufacturing may require additional validation studies, which the FDA must review and approve. If they are unable to successfully increase the manufacturing
capacity for a drug candidate, or we are unable to establish our own manufacturing capabilities, the commercial launch of any approved products may be delayed or there may be a shortage in supply.

We depend on third-party suppliers for key raw materials used in our manufacturing processes, and the loss of these third-party suppliers or their
inability to supply us with adequate raw materials could harm our business.

We rely on third-party suppliers for the
raw materials required for the production of our drug candidates. Our dependence on these third-party suppliers and the challenges we may face in obtaining adequate supplies of raw materials involve several risks, including limited control over
pricing, availability, quality, and delivery



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schedules. We cannot be certain that our current suppliers will continue to provide us with the quantities of these raw materials that we require or satisfy our anticipated specifications and
quality requirements. Any supply interruption in limited or sole sourced raw materials could materially harm our ability to manufacture our products until a new source of supply, if any, could be identified and qualified. Although we believe there
are several other suppliers of these raw materials, we may be unable to find a sufficient alternative supply channel in a reasonable time or on commercially reasonable terms. Any performance failure on the part of our suppliers could delay the
development and commercialization of our drug candidates, including limiting supplies necessary for clinical trials and regulatory approvals, or interrupt production of the existing products that are already marketed, which would have a material
adverse effect on our business.

Risks Related to Our Intellectual Property

If we are unable to adequately protect the intellectual property relating to our drug candidates, or if we infringe the rights of others, our
ability to successfully commercialize our drug candidates will be harmed.

We own or hold licenses to a number of
issued patents and U.S. pending patent applications, as well as foreign patents and pending PCT applications and foreign counterparts. Our success depends in part on our ability to obtain patent protection both in the United States and in other
countries for our drug candidates. Our ability to protect our drug candidates from unauthorized or infringing use by third parties depends in substantial part on our ability to obtain and maintain valid and enforceable patents. Due to evolving legal
standards relating to the patentability, validity and enforceability of patents covering pharmaceutical inventions and the scope of claims made under these patents, our ability to obtain, maintain and enforce patents is uncertain and involves
complex legal and factual questions. Accordingly, rights under any issued patents may not provide us with sufficient protection for our drug candidates or provide sufficient protection to afford us a commercial advantage against competitive products
or processes.

In addition, we cannot guarantee that any patents will issue from any pending or future patent applications
owned by or licensed to us. Even if patents have issued or will issue, we cannot guarantee that the claims of these patents are or will be valid or enforceable or will provide us with any significant protection against competitive products or
otherwise be commercially valuable to us. Patent applications in the United States are maintained in confidence for up to 18 months after their filing. In some cases, however, patent applications remain confidential in the U.S. Patent and Trademark
Office, or the U.S. Patent Office, for the entire time prior to issuance as a U.S. patent. Similarly, publication of discoveries in the scientific or patent literature often lag behind actual discoveries. Consequently, we cannot be certain that we
or our licensors or co-owners were the first to invent, or the first to file patent applications on, our drug candidates or their use as drugs. In the event that a third party has also filed a U.S. patent application relating to our drug candidates
or a similar invention, we may have to participate in interference proceedings declared by the U.S. Patent Office to determine priority of invention in the United States. The costs of these proceedings could be substantial and it is possible that
our efforts would be unsuccessful, resulting in a loss of our U.S. patent position. Furthermore, we may not have identified all U.S. and foreign patents or published applications that affect our business either by blocking our ability to
commercialize our drugs or by covering similar technologies.

The laws of some foreign jurisdictions do not protect
intellectual property rights to the same extent as in the United States and many companies have encountered significant difficulties in protecting and defending such rights in foreign jurisdictions. If we encounter such difficulties in protecting or
are otherwise precluded from effectively protecting our intellectual property rights in foreign jurisdictions, our business prospects could be substantially harmed.

The patent positions of biotechnology and pharmaceutical companies, including our patent position, involve complex legal and factual
questions, and, therefore, validity and enforceability cannot be predicted with certainty. Patents may be challenged, deemed unenforceable, invalidated, or circumvented. We will be able to protect our proprietary rights from unauthorized use by
third parties only to the extent that our proprietary technologies, drug candidates, and any future products are covered by valid and enforceable patents or are effectively maintained as trade secrets.



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We license patent rights from third-party owners. Our licenses may be subject to early termination if
we fail to comply with our obligations in our licenses with third parties.

We are party to a number of licenses that
give us rights to third-party intellectual property that is necessary or useful for our business. In particular, we have licenses from EpiCept Corporation (formerly Maxim Pharmaceuticals, Inc.) with respect to Azixa. We may also enter into
additional licenses to third-party intellectual property in the future. Our licensors may terminate their agreements with us in the event we breach the applicable license agreement and fail to cure the breach within a specified period of time. Under
our existing license agreements we are obligated to pay the licensor fees, which may include annual license fees, royalties, a percentage of revenues associated with the licensed technology and a percentage of sublicensing revenue. In addition,
under our existing license agreements, we are required to diligently pursue the development of products using the licensed technology. If we breach any of the terms of our licenses, the licensors may terminate the agreements.

Litigation regarding patents, patent applications and other proprietary rights may be expensive and time consuming. If we are involved in such
litigation, it could cause delays in bringing drug candidates to market and harm our ability to operate.

Our success
will depend in part on our ability to operate without infringing the proprietary rights of third parties. Although we are not currently aware of any litigation or other proceedings or third-party claims of intellectual property infringement related
to our drug candidates, the pharmaceutical industry is characterized by extensive litigation regarding patents and other intellectual property rights. Other parties may obtain patents in the future and allege that the use of our technologies
infringes these patent claims or that we are employing their proprietary technology without authorization.

In addition, third
parties may challenge or infringe upon our existing or future patents. Proceedings involving our patents or patent applications or those of others could result in adverse decisions regarding:



| |  |  | the patentability of our inventions relating to our drug candidates; and/or
| | - |  | ---------------------------------------------------------------------------



| |  |  | the enforceability, validity or scope of protection offered by our patents relating to our drug candidates.
| | - |  | -----------------------------------------------------------------------------------------------------------

Even if we are successful in these proceedings, we may incur substantial costs and divert management time and attention in pursuing these
proceedings, which could have a material adverse effect on us. If we are unable to avoid infringing the patent rights of others, we may be required to seek a license, defend an infringement action or challenge the validity of the patents in court.
Patent litigation is costly and time consuming. We may not have sufficient resources to bring these actions to a successful conclusion. In addition, if we do not obtain a license, develop or obtain non-infringing technology, fail to defend an
infringement action successfully or have infringed patents declared invalid, we may:



| |  |  | incur substantial monetary damages;
| | - |  | -----------------------------------



| |  |  | encounter significant delays in bringing our drug candidates to market; and/or
| | - |  | ------------------------------------------------------------------------------



| |  |  | be precluded from participating in the manufacture, use or sale of our drug candidates or methods of treatment requiring licenses.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------

We may be unable to adequately prevent disclosure of trade secrets and other proprietary information.

We rely on trade secrets to protect our proprietary technologies, especially where we do not believe patent protection
is appropriate or obtainable. However, trade secrets are difficult to protect. We rely in part on confidentiality agreements with our employees, consultants, outside scientific collaborators, sponsored researchers, and other advisors to protect our
trade secrets and other proprietary information. These agreements may not effectively prevent disclosure of confidential information and may not provide an adequate remedy in the event of unauthorized disclosure of confidential information. In
addition, others may independently discover our trade secrets and proprietary information. Costly and time-consuming litigation could be necessary to enforce and determine the scope of our proprietary rights, and failure to obtain or maintain trade
secret protection could adversely affect our competitive business position.



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Risks Relating to Our Separation from Myriad Genetics

Our historical financial information for periods ending on or prior to June 30, 2009 is not necessarily representative of the results we would
have achieved as a separate, publicly traded company and may not be a reliable indicator of our future results.

The
historical financial information we have included in this Annual Report on Form 10-K for periods ending on or prior to June 30, 2009 may not reflect what our results of operations, financial position and cash flows would have been had we been
an independent, publicly traded company during the periods presented or what our results of operations, financial position and cash flows are as an independent company. This is primarily because:



| |  |  | such historical financial information reflects allocations for services historically provided to us by Myriad Genetics, which allocations may not
reflect the costs we now incur for similar services as an independent company; and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | such historical financial information does not reflect changes that we will incur in the future as a result of our separation from Myriad Genetics,
including changes in the cost structure, personnel needs, financing and operations of the contributed businesses as a result of the separation from Myriad Genetics and from reduced economies of scale.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Following the separation, we are now responsible for the additional costs associated with being an independent, public company, including
costs related to corporate governance and listed and registered securities. Therefore, our financial statements for periods prior to June 30, 2009 may not be indicative of our performance as an independent company. For additional information
about our past financial performance and the basis of presentation of our financial statements, please see Selected Historical Financial Data, Managements Discussion and Analysis of Financial Condition and Results of
Operations and our financial statements and the notes thereto included elsewhere in this Annual Report on Form 10-K.

If the
distribution of our common stock or certain internal transactions undertaken in connection with the separation are determined to be taxable for U.S. federal income tax purposes, we, our stockholders that are subject to U.S. federal income tax, and
Myriad Genetics could incur significant U.S. federal income tax liabilities.

Myriad Genetics received a private letter
ruling from the Internal Revenue Service regarding the U.S. federal income tax consequences of the distribution of our common stock to the Myriad Genetics stockholders substantially to the effect that the distribution, except for cash received in
lieu of a fractional share of our common stock, qualified as tax-free under Sections 368(a)(1)(D) and 355 of the Internal Revenue Code of 1986, or the Code. The private letter ruling also provides that certain internal transactions undertaken
in anticipation of the separation qualified for favorable treatment under the Code. The private letter ruling relied on certain facts and assumptions, and certain representations and undertakings, from us and Myriad Genetics regarding the past and
future conduct of our respective businesses and other matters. Notwithstanding the private letter ruling, the Internal Revenue Service could determine on audit that the distribution or the internal transactions should be treated as taxable
transactions if it determines that any of these facts, assumptions, representations or undertakings is not correct or has been violated, or that the distributions should be taxable for other reasons, including as a result of significant changes in
stock or asset ownership after the distribution. If the distribution ultimately is determined to be taxable, the distribution could be treated as a taxable dividend or capital gain to stockholders who received our common stock in the separation for
U.S. federal income tax purposes, and such stockholders could incur significant U.S. federal income tax liabilities. In addition, Myriad Genetics would recognize gain in an amount equal to the excess of the fair market value of our common stock
distributed to Myriad Genetics stockholders on the distribution date over Myriad Genetics tax basis in such common shares. We and Myriad Genetics would incur significant U.S. federal income tax liabilities if it is ultimately determined that
certain internal transactions undertaken in anticipation of the separation should be treated as taxable transactions.



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In addition, under the terms of the Tax Sharing Agreement we entered into with Myriad
Genetics, in the event the distribution or the internal transactions were determined to be taxable and such determination was the result of actions taken after the distribution by us or Myriad Genetics, the party responsible for such failure would
be responsible for all taxes imposed on us or Myriad Genetics as a result thereof. Such tax amounts could be significant.

We might not
be able to engage in desirable strategic transactions and equity issuances because of restrictions relating to U.S. federal income tax requirements for tax-free distributions.

Our ability to engage in significant equity transactions could be limited or restricted in order to preserve for U.S. federal income tax
purposes the tax-free nature of the distribution of our common stock by Myriad Genetics in the separation. In addition, similar limitations and restrictions will apply to Myriad Genetics. Even if the distribution otherwise qualifies for tax-free
treatment under Sections 368(a)(1)(D) and 355 of the Code, it may result in corporate level taxable gain to Myriad Genetics under Section 355(e) of the Code if 50% or more, by vote or value, of our common stock or Myriad Genetics common stock
is acquired or issued as part of a plan or series of related transactions that includes the distribution. For this purpose, any acquisitions or issuances of Myriad Genetics common stock within two years before the distribution, and any
acquisitions or issuances of our common stock or Myriad Genetics common stock within two years after the distribution, generally are presumed to be part of such a plan, although we or Myriad Genetics may be able to rebut that presumption. We are not
aware of any such acquisitions or issuances of Myriad Genetics common stock within the two years before the distribution. If an acquisition or issuance of our common stock or Myriad Genetics common stock triggers the application of
Section 355(e) of the Code, Myriad Genetics would recognize taxable gain as described above, and certain subsidiaries of Myriad Genetics or subsidiaries of ours would incur significant U.S. federal income tax liabilities as a result of the
application of Section 355(e) of the Code.

Under the Tax Sharing Agreement, there are restrictions on our ability to
take actions that could cause the distribution or certain internal transactions undertaken in anticipation of the separation to fail to qualify as tax-favored transactions, including entering into, approving or allowing any transaction that results
in a change in ownership of more than 50% of our common shares, a redemption of equity securities, a sale or other disposition of a substantial portion of our assets, an acquisition of a business or assets with equity securities to the extent one or
more persons would acquire 50% or more of our common stock, or engaging in certain internal transactions. These restrictions apply for the two-year period after the distribution, unless we obtain a private letter ruling from the Internal
Revenue Service or an unqualified opinion that such action will not cause the distribution or the internal transactions undertaken in anticipation of the separation to fail to qualify as tax-favored transactions, and such letter ruling or opinion,
as the case may be, is acceptable to the parties. In addition, Myriad Genetics is subject to similar restrictions under the Tax Sharing Agreement. Moreover, the Tax Sharing Agreement generally provides that a party thereto is responsible for any
taxes imposed on any other party thereto as a result of the failure of the distribution or certain internal transactions to qualify as a tax-favored transaction under the Code if such failure is attributable to certain post-distribution actions
taken by or in respect of the responsible party or its stockholders, regardless of whether the actions occur more than two years after the distribution, the other parties consent to such actions or such party obtains a favorable letter ruling or
opinion as described above. For example, we would be responsible for the acquisition of us by a third party at a time and in a manner that would cause such failure. These restrictions may prevent us from entering into transactions which might be
advantageous to our shareholders.

Risks Related to Our Common Stock

Our stock price has been and is likely to continue to be volatile and the market price of our common stock may drop.

On June 12, 2009, trading of shares of our common stock began on The NASDAQ Global Market on a when-issued basis and has
continued on a regular basis since July 1, 2009. However, there can be no assurance that an active trading market for our common stock will continue or be sustained in the future. There is a limited history on which to gauge the
volatility of our stock price; however, since our common stock began



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regular trading on The NASDAQ Global Market on July 1, 2009 through June 30, 2010, our stock price has fluctuated from a low of $3.70 to a high of $6.81. Furthermore, the
stock market has recently experienced significant volatility, particularly with respect to pharmaceutical, biotechnology, and other life sciences company stocks. The volatility of pharmaceutical, biotechnology, and other life sciences company stocks
often does not relate to the operating performance of the companies represented by the stock. We cannot predict the prices at which our common stock may trade in the future. The market price of our common stock may continue to fluctuate widely,
depending upon many factors, some of which may be beyond our control, including:



| |  |  | progress in and results from our clinical trials of Azixa and MPC-3100;
| | - |  | -----------------------------------------------------------------------



| |  |  | failure or delays in advancing our preclinical drug candidates, including MPC-9528, or other drug candidates we may develop in the future, into
clinical trials;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | results of clinical trials conducted by others on drugs that would compete with our drug candidates;
| | - |  | ----------------------------------------------------------------------------------------------------



| |  |  | issues in manufacturing our drug candidates or approved products;
| | - |  | -----------------------------------------------------------------



| |  |  | regulatory developments or enforcement in the United States and foreign countries;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | developments or disputes concerning patents or other proprietary rights;
| | - |  | ------------------------------------------------------------------------



| |  |  | introduction of technological innovations or new commercial products by us or our competitors;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | changes in estimates or recommendations by securities analysts, if any cover our common stock;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | failure to secure adequate capital to fund our operations if and when needed, or the issuance of equity securities at prices below the current market
price;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | public concern over our drug candidates or any approved products;
| | - |  | -----------------------------------------------------------------



| |  |  | litigation;
| | - |  | -----------



| |  |  | future sales of our common stock;
| | - |  | ---------------------------------



| |  |  | general market conditions;
| | - |  | --------------------------



| |  |  | changes in the structure of healthcare payment systems;
| | - |  | -------------------------------------------------------



| |  |  | failure of any of our drug candidates, if approved, to achieve commercial success;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | economic and other external factors or other disasters or crises;
| | - |  | -----------------------------------------------------------------



| |  |  | period-to-period fluctuations in our financial results; and
| | - |  | -----------------------------------------------------------



| |  |  | overall fluctuations in U.S. equity markets.
| | - |  | --------------------------------------------

These and other external factors may cause the market price and demand for our common stock to fluctuate substantially, which may limit
or prevent investors from readily selling their shares of common stock and may otherwise negatively affect the liquidity of our common stock. In the past, when the market price of a stock has been volatile, holders of that stock have instituted
securities class action litigation against the company that issued the stock. If any of our stockholders brought a lawsuit against us, we could incur substantial costs defending the lawsuit. Such a lawsuit could also divert the time and attention of
our management.



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Provisions of our charter and bylaws and Delaware law and our shareholder rights agreement, or poison
pill, may make an acquisition of us or a change in our management more difficult.

Certain provisions of our restated
certificate of incorporation and restated bylaws could discourage, delay, or prevent a merger, acquisition, or other change in control that stockholders may consider favorable, including transactions in which you might otherwise receive a premium
for your shares. Stockholders who wish to participate in these transactions may not have the opportunity to do so. These provisions also could limit the price that investors might be willing to pay for shares of our common stock, thereby depressing
the market price of our common stock. Furthermore, these provisions could prevent or frustrate attempts by our stockholders to replace or remove our management. These provisions:



| |  |  | allow the authorized number of directors to be changed only by resolution of our board of directors;
| | - |  | ----------------------------------------------------------------------------------------------------



| |  |  | establish a classified board of directors, providing that not all members of our board be elected at one time;
| | - |  | --------------------------------------------------------------------------------------------------------------



| |  |  | authorize our board of directors to issue without stockholder approval blank check preferred stock;
| | - |  | ---------------------------------------------------------------------------------------------------



| |  |  | require that stockholder actions must be effected at a duly called stockholder meeting and prohibit stockholder action by written consent;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | establish advance notice requirements for stockholder nominations to our board of directors or for stockholder proposals that can be acted on at
stockholder meetings;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | limit who may call stockholder meetings; and
| | - |  | --------------------------------------------



| |  |  | require the approval of the holders of 80% of the outstanding shares of our capital stock entitled to vote in order to amend certain provisions of our
restated certificate of incorporation and restated bylaws.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We have also implemented a shareholder rights
plan (commonly known as a poison pill), which could make it uneconomical for a third party to acquire us on a hostile basis. In addition, because we are incorporated in Delaware, we are governed by the provisions of Section 203 of
the Delaware General Corporation Law, which may, unless certain criteria are met, prohibit large stockholders, in particular those owning 15% or more of our outstanding voting stock, from merging or combining with us for a prescribed period of time.

We do not anticipate paying cash dividends, and accordingly, stockholders must rely on stock appreciation for any return on their
investment.

We currently anticipate that we will retain future earnings for the development, operation and expansion
of our business and do not anticipate declaring or paying any cash dividends for the foreseeable future. Therefore, the success of an investment in shares of our common stock will depend upon any future appreciation in their value. There is no
guarantee that shares of our common stock will appreciate in value or even maintain the price at which our stockholders have purchased their shares.

A failure to maintain adequate internal control over financial reporting in accordance with Section 404 of the Sarbanes-Oxley Act of 2002 or
prevent or detect material misstatements in our annual or interim consolidated financial statements in the future could materially harm our business and cause our stock price to decline.

As a public company, our internal control over financial reporting is required to comply with the standards adopted by the Public Company
Accounting Oversight Board in compliance with the requirements of Section 404 of the Sarbanes-Oxley Act of 2002. Accordingly, we are currently required to document and test our internal controls and procedures to assess the effectiveness of our
internal control over financial reporting. In addition, our independent registered public accounting firm is currently required to report on managements assessment of the effectiveness of our internal control over financial reporting and the
effectiveness of our internal control over financial reporting. If we are unable to maintain effective control over financial reporting, such conclusion would be disclosed in this and/or subsequent Annual Reports on Form 10-K. In the future, we
may identify material weaknesses and deficiencies which we may not be able to remediate in a timely manner. If we fail to maintain effective internal control over financial reporting in accordance with Section 404, we will not be able to
conclude



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that we have and maintain effective internal control over financial reporting or our independent registered accounting firm may not be able to issue an unqualified report on the effectiveness of
our internal control over financial reporting. As a result, our ability to report our financial results on a timely and accurate basis may be adversely affected, we may be subject to sanctions or investigation by regulatory authorities, including
the SEC or The NASDAQ Global Market and investors may lose confidence in our financial information, which in turn could cause the market price of our common stock to decrease. We may also be required to restate our financial statements from prior
periods. In addition, testing and maintaining internal control in accordance with Section 404 requires increased management time and resources. Any failure to maintain effective internal control over financial reporting could impair the success
of our business and harm our financial results.



|Item 1B. | UNRESOLVED STAFF COMMENTS
|-------- | -------------------------

Not applicable.



|Item 2. | PROPERTIES
|------- | ----------

Our
headquarters and facilities are located in Salt Lake City, Utah. We currently lease 87,000 square feet of office and laboratory space from Myriad Genetics, Inc., our former parent company, under a sublease with an initial term expiring January 2013
renewable at our election for a total of an additional 12 years in three-year increments.

We believe our existing facilities
and equipment are well maintained and in good working condition and that our current facilities will provide adequate capacity for at least the next three years and that additional space, if needed, will be available in the future on commercially
reasonable terms.



|Item 3. | LEGAL PROCEEDINGS
|------- | -----------------

Beginning on December 23, 2009, several putative stockholder class action lawsuits were filed against Javelin Pharmaceuticals, Inc.,
members of Javelins board of directors, Myrexis, Inc. and MPI Merger Sub, a wholly owned subsidiary of Myrexis, Inc., in the Suffolk Superior Court Business Litigation Session in Massachusetts. The actions, first served on Javelin on
January 5, 2010, styled Schnipper v. Watson et al., Parrish v. Watson et al. and Andrews v. Driscoll et al., alleged, among other things, that the members of Javelins board of directors violated their fiduciary duties by failing to
maximize value for Javelins stockholders when negotiating and entering into the Agreement and Plan of Merger with Myrexis and MPI Merger Sub, dated December 18, 2009, pursuant to which MPI Merger Sub was to be merged with and into
Javelin, with Javelin continuing after the merger as the surviving corporation and a wholly owned subsidiary of Myrexis. The complaints also alleged that Myrexis, MPI Merger Sub and Javelin aided and abetted those purported breaches. Plaintiffs
sought, among other things, to enjoin the proposed merger or, in the alternative, to rescind the proposed merger should it occur before the lawsuits were resolved. On January 13, 2010, the parties filed a stipulation and proposed order
consolidating the actions. The order was entered by the court on January 21, 2010. Pursuant to the stipulation, plaintiffs filed a consolidated amended complaint on February 23, 2010. Plaintiffs also filed an emergency motion
seeking expedited discovery, which defendants opposed. After a March 12, 2010, hearing on the motion for expedited discovery, the court denied the motion. On April 19, 2010, after receipt of an acquisition proposal from Hospira, Inc.,
Javelin terminated the merger agreement with Myrexis. On May 3, 2010, plaintiffs filed an emergency motion seeking leave to serve a second amended complaint challenging the potential acquisition of Javelin by Hospira. In addition, on
May 5, 2010, plaintiffs filed an emergency motion seeking expedited discovery from Javelin and an order preliminarily enjoining the potential acquisition of Javelin by Hospira. Myrexis and MPI Merger Sub were not named as defendants in the
putative second amended complaint and plaintiffs emergency motions did not seek any relief against Myrexis or MPI Merger Sub. Hospira acquired Javelin via a tender offer and the case was subsequently dismissed with prejudice against the
Javelin defendants on July 16, 2010.



|Item 4. | REMOVED AND RESERVED
|------- | --------------------



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PART II



|Item 5. | MARKET FOR REGISTRANTS COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES
|------- | ------------------------------------------------------------------------------------------------------------

Market Information

Our
common stock is traded on The NASDAQ Global Market under the symbol MYRX. On June 12, 2009, prior to our separation from Myriad Genetics, trading in shares of our common stock began on a when-issued basis on The NASDAQ
Global Market under the symbol MYRXV and continued up to and including June 30, 2009, the date of the separation. Since June 30, 2009, our common stock has traded on a regular basis under the symbol
MYRX. The following table sets forth the high and low sales prices for our common stock as reported by The NASDAQ Global Market for the periods indicated.



|                                 |  |      |      |     |   |     
|-------------------------------- |  | ---- | ---- | --- | - | ----
|                                 |  | High |      | Low
|Fiscal Year Ended June 30, 2010: |  |      |      |     |   |     
|Fourth Quarter                   |  | $    | 5.25 |     | $ | 3.70
|Third Quarter                    |  | $    | 5.43 |     | $ | 4.19
|Second Quarter                   |  | $    | 6.81 |     | $ | 4.75
|First Quarter                    |  | $    | 6.80 |     | $ | 3.81



|                                    |  |      |      |     |   |     
|----------------------------------- |  | ---- | ---- | --- | - | ----
|                                    |  | High |      | Low
|Fiscal Year Ended June 30, 2009:    |  |      |      |     |   |     
|Fourth Quarter (from June 12, 2009) |  | $    | 7.49 |     | $ | 3.63

Stockholders

As of September 7, 2010, there were approximately 109 stockholders of record of our common stock and, according to our estimates,
approximately 12,098 beneficial owners of our common stock.

Dividends

We have not paid cash dividends to our stockholders since our inception and we do not plan to pay cash dividends in the foreseeable
future. We currently intend to retain earnings, if any, to finance our growth.

Unregistered Sales of Securities

None.

Issuer Purchases of
Equity Securities

None.



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##### Table of Contents

Stock Performance Graph

The graph set forth below compares the annual percentage change in our cumulative total stockholder return on our common stock, during a
period commencing on June 12, 2009 (the first day of trading of our common stock on The NASDAQ Global Market) and ending on June 30, 2010 (as measured by dividing (A) the difference between our share price at the end and the beginning
of the measurement period; by (B) our share price at the beginning of the measurement period) with the cumulative total return of The NASDAQ Stock Market, Inc. and the NASDAQ Biotech Index during such period. We have not paid any cash dividends
on our common stock, and we do not include cash dividends in the representation of our performance. The price of a share of common stock is based upon the closing price per share as quoted on The NASDAQ Global Market on the last trading day of the
year shown. The graph lines merely connect quarter-end values and do not reflect fluctuations between those dates. The comparison assumes $100 was invested on June 12, 2009 in our common stock and in each of the foregoing
indices. The comparisons shown in the graph below are based upon historical data. We caution that the stock price performance shown in the graph below is not necessarily indicative of, nor is it intended to forecast, the potential future
performance of our common stock.

LOGO



|                           |  |            |  |            |  |            |  |            |  |            |  |           
|-------------------------- |  | ---------- |  | ---------- |  | ---------- |  | ---------- |  | ---------- |  | ----------
|                           |  | 06/12/2009 |  | 06/30/2009 |  | 09/30/2009 |  | 12/31/2009 |  | 03/31/2010 |  | 06/30/2010
|Myrexis, Inc.              |  | 100.00     |  | 66.43      |  | 83.71      |  | 71.86      |  | 64.57      |  | 53.71     
|                           |  |            |  |            |  |           
|NASDAQ Biotechnology Index |  | 100.00     |  | 103.19     |  | 115.59     |  | 116.13     |  | 129.27     |  | 110.13    
|                           |  |            |  |            |  |           
|NASDAQ Composite Index     |  | 100.00     |  | 98.72      |  | 114.18     |  | 122.08     |  | 129.69     |  | 113.47    

The
performance graph shall not be deemed to be incorporated by reference by means of any general statement incorporating by reference this Form 10-K into any filing under the Securities Act of 1933, as amended or the Securities Exchange Act of 1934, as
amended, except to the extent that we specifically incorporate such information by reference, and shall not otherwise be deemed filed or soliciting material under such acts.



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##### Table of Contents

|Item 6. | SELECTED FINANCIAL DATA
|------- | -----------------------

The following table sets forth selected financial information as of and for each of the years in the five-year period ended June 30,
2010, which has been derived from our (1) audited financial statements as of June 30, 2010 and 2009 and for the years ended June 30, 2010, 2009 and 2008, which are included elsewhere in this Form 10-K; (2) audited financial
statements as of June 30, 2008 and 2007 and for the years ended June 30, 2007 and 2006, which are not included elsewhere in this Form 10-K and (3) unaudited balance sheet as of June 30, 2006, which is not included elsewhere in
this Form 10-K. In our opinion, the information derived from our unaudited balance sheet is presented on a basis consistent with the information in our audited financial statements. Because our historical financial information for periods ending on
or prior to June 30, 2009 reflects allocations for services historically provided to us by Myriad Genetics, the selected financial information presented below for such periods may not be indicative of our results of operations and financial
position as an independent company. The selected financial information presented for the year ended June 30, 2010, reflects our performance as an independent company. See Risk FactorsRisks Relating to Our Separation from Myriad
Genetics.

The selected financial data below should be read in conjunction with our audited financial statements (and
notes thereon) and Managements Discussion and Analysis of Financial Condition and Results of Operations, included elsewhere in this Form 10-K.



|                                                     |  |                      |         |   |      |   |         |      |  |   |         |      |  |      |         |   |  |   |         |  
|---------------------------------------------------- |  | -------------------- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | ---- |  | ---- | ------- | - |  | - | ------- | -
|                                                     |  | Years ended June 30, |        
|In thousands (except per share data)                 |  | 2010                 |         |   | 2009 |   |         | 2008 |  |   | 2007    |      |  | 2006 |        
|Statement of Operations Data:                        |  |                      |         |   |      |   |         |      |  |   |         |      |  |      |         |   |  |   |         |  
|Research revenue                                     |  | $                    | 90      |   |      | $ | 5,456   |      |  | $ | 6,774   |      |  | $    | 11,841  |   |  | $ | 13,658  |  
|Pharmaceutical revenue                               |  |                      |        |   |      |   |        |      |  |   | 100,000 | (1)  |  |      |        |   |  |   |        |  
|Other revenue                                        |  |                      |        |   |      |   |        |      |  |   | 4,000   |      |  |      |        |   |  |   |        |  
|                                                     |  |                      |         |   |      |   |         |      |  |   |         |      |  |      |         |   |  |   |         |  
|Total revenues                                       |  |                      | 90      |   |      |   | 5,456   |      |  |   | 110,774 |      |  |      | 11,841  |   |  |   | 13,658  |  
|Costs and expenses:                                  |  |                      |         |   |      |   |         |      |  |   |         |      |  |      |         |   |  |   |         |  
|Research and development expense                     |  |                      | 28,222  |   |      |   | 54,611  |      |  |   | 121,526 | (2)  |  |      | 94,929  |   |  |   | 77,682  |  
|Selling, general and administrative expense          |  |                      | 19,984  |   |      |   | 8,981   |      |  |   | 20,600  |      |  |      | 10,250  |   |  |   | 6,955   |  
|                                                     |  |                      |         |   |      |   |         |      |  |   |         |      |  |      |         |   |  |   |         |  
|Total costs and expenses                             |  |                      | 48,206  |   |      |   | 63,592  |      |  |   | 142,126 |      |  |      | 105,179 |   |  |   | 84,637  |  
|                                                     |  |                      |         |   |      |   |         |      |  |   |         |      |  |      |         |   |  |   |         |  
|Operating loss                                       |  |                      | (48,116 | ) |      |   | (58,136 | )    |  |   | (31,352 | )    |  |      | (93,338 | ) |  |   | (70,979 | )
|Other income (expense), net                          |  |                      | 1,165   |   |      |   |        |      |  |   | (3,017  | )(3) |  |      | 653     |   |  |   | (2      | )
|                                                     |  |                      |         |   |      |   |         |      |  |   |         |      |  |      |         |   |  |   |         |  
|Net loss                                             |  | $                    | (46,951 | ) |      | $ | (58,136 | )    |  | $ | (34,369 | )    |  | $    | (92,685 | ) |  | $ | (70,981 | )
|                                                     |  |                      |         |   |      |   |         |      |  |   |         |      |  |      |         |   |  |   |         |  
|Net loss per basic and diluted share (4)             |  | $                    | (1.91   | ) |      | $ | (2.43   | )    |  | $ | (1.43   | )    |  | $    | (3.87   | ) |  | $ | (2.96   | )
|                                                     |  |                      |         |   |      |   |         |      |  |   |         |      |  |      |         |   |  |   |         |  
|                                                     | 
|                                                     |  | As of June 30,       |        
|In thousands                                         |  | 2010                 |         |   | 2009 |   |         | 2008 |  |   | 2007    |      |  | 2006 |        
|Balance Sheet Data:                                  |  |                      |         |   |      |   |         |      |  |   |         |      |  |      |         |   |  |   |         |  
|Cash, cash equivalents and marketable securities (5) |  | $                    | 147,453 |   |      | $ | 188,005 |      |  | $ |        |      |  | $    |        |   |  | $ |        |  
|Current liabilities                                  |  |                      | 4,250   |   |      |   | 4,576   |      |  |   | 46,568  |      |  |      | 10,875  |   |  |   | 16,201  |  
|Total assets                                         |  |                      | 154,108 |   |      |   | 193,677 |      |  |   | 15,746  |      |  |      | 16,244  |   |  |   | 17,188  |  
|Total shareholders / parent equity (6)              |  | $                    | 149,858 |   |      | $ | 189,101 |      |  | $ | (30,822 | )    |  | $    | 5,369   |   |  | $ | 987     |  



|(1) | Represents a nonrefundable upfront payment from A/S Lundbeck for the former drug candidate Flurizan.
|--- | ----------------------------------------------------------------------------------------------------



|(2) | Amount includes an accrued $20 million sublicense fee payable related to Flurizan.
|--- | ----------------------------------------------------------------------------------



|(3) | Amount includes the write-off of the cost basis investment in Encore Pharmaceuticals.
|--- | -------------------------------------------------------------------------------------



|(4) | For years ended June 30, 2009, 2008, 2007 and 2006, pro forma net loss per share calculated based on the 23,974,211 shares issued in connection with the spin-off.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(5) | Prior to June 30, 2009, all cash and investments were held and managed by Myriad Genetics.
|--- | ------------------------------------------------------------------------------------------



|(6) | Balances prior to June 30, 2009 represent Myriad Genetics net investment (or capital deficiency) in Myrexis.
|--- | -------------------------------------------------------------------------------------------------------------



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##### Table of Contents

Quarterly Financial Data (Unaudited)



|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|-------------------------------------------- |  | ------------- | ------- | --- | ------------- | - | ------- | ---------------- |  | - | ----------------- | - |  | - | ------- | -
|                                             |  | Quarter Ended |        
|In thousands                                 |  | June 30,2010  |         |     | March 31,2010 |   |         | December 31,2009 |  |   | September 30,2009 |  
|Research revenue                             |  | $             |        |     |               | $ | 30      |                  |  | $ |                  |   |  | $ | 60      |  
|Pharmaceutical revenue                       |  |               |        |     |               |   |        |                  |  |   |                  |   |  |   |        |  
|Other revenue                                |  |               |        |     |               |   |        |                  |  |   |                  |   |  |   |        |  
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Total revenue                                |  |               |        |     |               |   | 30      |                  |  |   |                  |   |  |   | 60      |  
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Costs and expenses:                          |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Research and development expense             |  |               | 6,935   |     |               |   | 7,190   |                  |  |   | 8,217             |   |  |   | 5,880   |  
|Selling, general, and administrative expense |  |               | 894     | (1) |               |   | 6,926   |                  |  |   | 6,928             |   |  |   | 5,236   |  
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Total costs and expenses                     |  |               | 7,829   |     |               |   | 14,116  |                  |  |   | 15,145            |   |  |   | 11,116  |  
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Operating loss                               |  |               | (7,829  | )   |               |   | (14,086 | )                |  |   | (15,145           | ) |  |   | (11,056 | )
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Other income, net                            |  |               | 22      |     |               |   | 363     |                  |  |   | 355               |   |  |   | 425     |  
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Net loss                                     |  | $             | (7,807  | )   |               | $ | (13,723 | )                |  | $ | (14,790           | ) |  | $ | (10,631 | )
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|                                             | 
|                                             |  | Quarter Ended |        
|                                             |  | June 30,2009  |         |     | March 31,2009 |   |         | December 31,2008 |  |   | September 30,2008 |  
|Research revenue                             |  | $             | 392     |     |               | $ | 956     |                  |  | $ | 424               |   |  | $ | 3,684   |  
|Pharmaceutical revenue                       |  |               |        |     |               |   |        |                  |  |   |                  |   |  |   |        |  
|Other revenue                                |  |               |        |     |               |   |        |                  |  |   |                  |   |  |   |        |  
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Total revenue                                |  |               | 392     |     |               |   | 956     |                  |  |   | 424               |   |  |   | 3,684   |  
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Costs and expenses:                          |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Research and development expense             |  |               | 12,914  |     |               |   | 13,401  |                  |  |   | 15,461            |   |  |   | 12,835  |  
|Selling, general, and administrative expense |  |               | 1,824   |     |               |   | 2,634   |                  |  |   | 2,052             |   |  |   | 2,471   |  
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Total costs and expenses                     |  |               | 14,738  |     |               |   | 16,035  |                  |  |   | 17,513            |   |  |   | 15,306  |  
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Operating loss                               |  |               | (14,346 | )   |               |   | (15,079 | )                |  |   | (17,089           | ) |  |   | (11,622 | )
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Other income, net                            |  |               |        |     |               |   |        |                  |  |   |                  |   |  |   |        |  
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  
|Net loss                                     |  | $             | (14,346 | )   |               | $ | (15,079 | )                |  | $ | (17,089           | ) |  | $ | (11,622 | )
|                                             |  |               |         |     |               |   |         |                  |  |   |                   |   |  |   |         |  



|(1) | Reflects reimbursement of $1.5 million in stipulated expenses and a $2.9 million termination fee in connection with the proposed merger with Javelin Pharmaceuticals,
Inc. that was terminated in April 2010.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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|Item 7. | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
|------- | -------------------------------------------------------------------------------------

The following discussion and analysis should be read together with Selected Financial Data, and the financial statements
and the related notes appearing elsewhere in this Form 10-K. This discussion and analysis contains forward-looking statements that involve risks, uncertainties and assumptions. Information regarding these forward-looking statements can be found in
the preface to Part I, Item 1 Business of this Form 10-K. Our actual results may differ materially from those anticipated in these forward-looking statements as a result of certain factors, including, but not limited to, those set
forth under Risk Factors and elsewhere in this Form 10-K.

Overview

We are a biotechnology company focused on discovering, developing and commercializing novel treatments for cancer. Our
development pipeline includes clinical and pre-clinical product candidates with distinct mechanisms of action and novel chemical structures that have the potential to be first-in-class and/or best-in-class therapeutics. The discovery and
development of each of our drug candidates has been guided by a unique understanding of the genetic causes of human diseases, and the genetic factors that may cause drug side effects, drug interactions, and drug metabolism. Our extensive experience
in human genetics, protein-protein interaction technology and chemical proteomic drug discovery has allowed identification of novel drug targets and accelerated progression from chemical lead compounds to investigational drug candidates.

We were incorporated as Myriad Pharmaceuticals, Inc. in Delaware in January 2009 as a new, wholly owned subsidiary of Myriad Genetics,
Inc. in order to effect the separation and spin-off of Myriad Genetics research and drug development businesses as a stand-alone, independent, publicly traded company. In connection with the formation of this new subsidiary, Myriad
Genetics existing subsidiary, Myriad Pharmaceuticals, Inc., changed its corporate name to Myriad Therapeutics, Inc., and we adopted the name of Myriad Pharmaceuticals, Inc. which was subsequently changed to Myrexis, Inc. effective July 1,
2010. On June 30, 2009, Myriad Genetics contributed substantially all of the assets and certain liabilities of its research and drug development businesses as well as $188 million in cash and marketable securities to us and effected the
spin-off of our company through a pro rata dividend distribution to its stockholders of all outstanding shares of our common stock.

We operate in one reportable operating segment that includes research and drug development. Until the fiscal year ended June 30,
2008, our revenues consisted primarily of research payments related to research collaboration agreements. In fiscal 2008, our revenue included a $100.0 million non-refundable fee received from H. Lundbeck A/S, or Lundbeck, in connection with an
agreement granting Lundbeck European commercialization rights to Flurizan, our former drug candidate for the treatment of Alzheimers disease. During the year ended June 30, 2010, we reported $90,000 in revenues associated with
collaborative external agreements and a net loss of $47.0 million.

We expect to incur significant net losses for the
foreseeable future and that such losses will fluctuate from quarter to quarter and that such fluctuations may be substantial. Additionally, we expect to incur substantial sales, marketing and other expenses in preparation for the commercialization
of our drug candidates and some of these expenses will be incurred prior to FDA approval, which approval is not assured.

Our
drug research and development expenses include costs incurred for our current clinical-stage drug candidates, Azixa and MPC-3100, our most advanced preclinical-stage drug candidate, MPC-9528, as well as our discontinued drug candidates MPC-4326,
MPC-9055, and Flurizan. Currently, the only costs we track by each drug candidate are external costs such as services provided to us by clinical research organizations, manufacturing of drug supply, and other outsourced research. We do not assign or
allocate internal costs such as salaries and benefits, facilities costs, lab supplies and the costs of preclinical research and studies to individual development programs. We also incurred costs related to external research collaborations from our
research services business. We track all underlying principal costs associated with our research collaborations. All development costs for our drug candidates and external research collaborations are expensed as incurred. Our



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research and development expense for each of our current clinical-stage programs, Azixa and MPC-3100, our most advanced preclinical-stage drug candidate, MPC-9528, as well as our discontinued
drug candidates MPC-4326, MPC-9055, and Flurizan during the fiscal years ended June 30, 2010, 2009 and 2008 are as follows:



|                                 |  |                      |        |      |   |        |      |  |   |        
|-------------------------------- |  | -------------------- | ------ | ---- | - | ------ | ---- |  | - | -------
|                                 |  | Years Ended June 30,
|(In thousands)                   |  | 2010                 |        | 2009 |   |        | 2008
|External costs, drug candidates: |  |                      |        |      |   |        |      |  |   |        
|Azixa                            |  | $                    | 2,998  |      | $ | 4,279  |      |  | $ | 2,981  
|MPC-4326                         |  |                      | 1,720  |      |   | 9,175  |      |  |   |       
|MPC-3100                         |  |                      | 2,568  |      |   | 2,952  |      |  |   | 463    
|MPC-9055                         |  |                      |       |      |   | 2,867  |      |  |   | 4,863  
|MPC-9528                         |  |                      | 14     |      |   |       |      |  |   |       
|Flurizan                         |  |                      |       |      |   | (9,861 | )    |  |   | 66,147 
|                                 |  |                      |        |      |   |        |      |  |   |        
|Sub-total direct costs           |  |                      | 7,300  |      |   | 9,412  |      |  |   | 74,454 
|Internal costs, drug candidates  |  |                      | 5,965  |      |   | 7,508  |      |  |   | 7,158  
|Preclinical development costs    |  |                      | 13,812 |      |   | 35,677 |      |  |   | 35,035 
|External research collaborations |  |                      | 1,145  |      |   | 2,014  |      |  |   | 4,879  
|                                 |  |                      |        |      |   |        |      |  |   |        
|Total research and development   |  | $                    | 28,222 |      | $ | 54,611 |      |  | $ | 121,526
|                                 |  |                      |        |      |   |        |      |  |   |        

The timing and amount of any future expenses,
completion dates, and revenues for our drug candidates is not readily determinable due to the early stage of these development programs.

We do not know if we will be successful in developing any of our drug candidates. While expenses associated with the completion of our
current clinical programs are expected to be substantial and increase, we believe that accurately projecting total program-specific expenses through commercialization is not possible at this time. The timing and amount of these expenses will depend
upon the costs associated with potential future clinical trials of our drug candidates, and the related expansion of our research and development organization, regulatory requirements, advancement of our preclinical programs and product
manufacturing costs, many of which cannot be determined with accuracy at this time. We are also unable to predict when, if ever, material net cash inflows will commence from our drug candidates. This is due to the numerous risks and uncertainties
associated with the duration and cost of clinical trials, which vary significantly over the life of a project as a result of unanticipated events arising during clinical development, including:



| |  |  | the scope, rate of progress, and expense of our clinical trials and other research and development activities;
| | - |  | --------------------------------------------------------------------------------------------------------------



| |  |  | the length of time required to enroll suitable subjects;
| | - |  | --------------------------------------------------------



| |  |  | the number of subjects that ultimately participate in the trials;
| | - |  | -----------------------------------------------------------------



| |  |  | the efficacy and safety results of our clinical trials and the number of additional required clinical trials;
| | - |  | -------------------------------------------------------------------------------------------------------------



| |  |  | the terms and timing of regulatory approvals;
| | - |  | ---------------------------------------------



| |  |  | our ability to market, commercialize, manufacture and supply, and achieve market acceptance for our drug candidates that we are developing or may
develop in the future; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the filing, prosecuting, defending or enforcement of any patent claims or other intellectual property rights.
| | - |  | -------------------------------------------------------------------------------------------------------------

A change in the outcome of any of the foregoing variables in the development of a drug candidate could mean a significant change in the
costs and timing associated with the development of that drug candidate. For example, if the FDA or another regulatory authority were to require us to conduct clinical trials beyond those which we currently anticipate to complete clinical
development of a drug candidate, or if we experience significant delays in the enrollment of patients in any of our clinical trials, we would be required to expend significant additional financial resources and time on the completion of clinical
development.



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Critical Accounting Policies and Use of Estimates

Critical accounting policies are those policies which are both important to the portrayal of a companys financial condition and
results and require managements most difficult, subjective or complex judgments, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. Our critical accounting policies are as follows:



| |  |  | revenue recognition;
| | - |  | --------------------



| |  |  | income taxes;
| | - |  | -------------



| |  |  | clinical trial expenses; and
| | - |  | ----------------------------



| |  |  | share-based payment expense.
| | - |  | ----------------------------

Revenue Recognition

Revenue from non-refundable upfront license fees where we have continuing involvement is recognized ratably over the development or
agreement period or upon termination of a development or license agreement when we have no ongoing obligation.

Research
revenue includes revenue from research services agreements, milestone payments, and technology licensing agreements. In applying the principles of revenue recognition to research and technology license agreements we consider the terms and conditions
of each agreement separately to arrive at a proportional performance methodology of recognizing revenue. Such methodologies involve recognizing revenue on a straight-line basis over the term of the agreement, as underlying research costs are
incurred, or on the basis of contractually defined output measures such as units delivered. We make adjustments, if necessary, to the estimates used in our calculations as work progresses and we gain experience. The principal costs under these
agreements are for personnel expenses to conduct research and development but also include costs for materials and other direct and indirect items necessary to complete the research under these agreements. Actual results may vary from our estimates.
Payments received on uncompleted long-term contracts may be greater than or less than incurred costs and estimated earnings and have been recorded as other receivables or deferred revenues in the accompanying balance sheets. Revenue from milestone
payments for which we have no continuing performance obligations is recognized upon achievement of the related milestone. When we have continuing performance obligations, the milestone payments are deferred and recognized as revenue over the term of
the arrangement as we complete our performance obligations. We recognize revenue from upfront nonrefundable license fees on a straight-line basis over the period of our continued involvement in the research and development project.

Income Taxes

Our
income tax provision is based on income before taxes and is computed using the liability method in accordance with Accounting Standards Codification, or ASC, 740Income Taxes. Deferred tax assets and liabilities are determined based on
the difference between the financial statement and tax basis of assets and liabilities using tax rates projected to be in effect for the year in which the differences are expected to reverse. Significant estimates are required in determining our
provision for income taxes. Some of these estimates are based on interpretations of existing tax laws or regulations, or the expected results from any future tax examinations. Various internal and external factors may have favorable or unfavorable
effects on our future provision for income taxes. Those factors include, but are not limited to, changes in tax laws, regulations and/or rates, the results of any future tax examinations, changing interpretations of existing tax laws or regulations,
changes in estimates of prior years items, past levels of R&D spending, acquisitions, changes in our corporate structure, and changes in overall levels of income before taxes all of which may result in periodic revisions to our provision
for income taxes.

Developing our provision for income taxes, including our effective tax rate and analysis of potential
uncertain tax positions, if any, requires significant judgment and expertise in federal and state income tax laws, regulations and strategies, including the determination of deferred tax assets and liabilities and any estimated



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valuation allowance we deem necessary to offset deferred tax assets. During the fiscal year ended June 30, 2010, we determined that a valuation allowance was necessary to fully offset our
deferred tax assets. Our judgment and tax strategies are subject to audit by various taxing authorities. While we believe we have provided adequately for our uncertain income tax positions in our consolidate financial statements, adverse
determination by these taxing authorities could have a material adverse effect on our consolidated financial condition, results of operations or cash flows. Interest and penalties on income tax items are included as a component of overall income tax
expense.

Clinical Trial Expenses

The cost of our clinical trials is based, in part, on estimates of the services received and efforts expended pursuant to contracts with
numerous clinical trial centers and clinical research organizations, or the CROs. In the normal course of business, we contract with third parties to perform various clinical trial activities in the ongoing development of our drug candidates. The
financial terms of these agreements vary from contract to contract, are subject to negotiation and may result in uneven payment flows. Payments under the contracts depend on factors such as the achievement of certain events, the successful
enrollment of patients or the completion of portions of the clinical trial or similar conditions. The objective of our accrual policy is to match the recording of expenses in our financial statements to the actual services received and efforts
expended. As such, we recognize direct expenses related to each patient enrolled in a clinical trial on an estimated cost-per-patient basis as services are performed. In addition to considering information from our clinical operations group
regarding the status of our clinical trials, we rely on information from CROs, such as estimated costs per patient, to calculate our accrual for direct clinical expenses at the end of each reporting period. For indirect expenses, which relate to
site and other administrative costs to manage our clinical trials, we rely on information provided by the CRO, including costs incurred by the CRO as of a particular reporting date, to calculate our indirect clinical expenses. In the event of early
termination of a clinical trial, we would recognize expenses in an amount based on our estimate of the remaining non-cancelable obligations associated with the winding down of the clinical trial, which we would confirm directly with the CRO.

If our CROs were to either under or over report the costs that they have incurred or if there is a change in the estimated
per patient costs, it could have an impact on our clinical trial expenses during the period in which they report a change in estimated costs to us. Adjustments to our clinical trial accruals primarily relate to indirect costs, for which we place
significant reliance on our CROs for accurate information at the end of each reporting period.

Share-Based Payment Expense

Share-based compensation expense standards set accounting requirements for share-based compensation to employees,
including employee stock purchase plans, and require us to recognize, as expense, in our statements of operations, the grant date fair value of our stock options and other equity-based compensation. The determination of grant date fair value is
estimated using an option-pricing model, which includes variables such as the terms of each grant, the expected volatility of our share price, the exercise behavior of our employees, interest rates, and dividend yields. These variables are projected
based on our historical data, experience, and other factors. Changes in any of these variables could result in material adjustments to the expense recognized for share-based payments.

In connection with the separation and spin-off from Myriad Genetics and related transactions, each outstanding Myriad Genetics stock
option was converted into an adjusted Myriad Genetics common stock option, exercisable for the same number of shares of common stock as the original Myriad Genetics option, and a new Myrexis common stock option, exercisable for one-fourth of the
number of shares of common stock as the original Myriad Genetics option. An adjusted exercise price of each converted option was determined in accordance with Section 409A and Section 422 of the Internal Revenue Code of 1986, as amended.
All other terms of the converted options remain the same however; the vesting and expiration of the converted options will be based on the optionholders continuing employment with Myriad Genetics or Myrexis, as applicable, following the
separation.



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As a result of the option modifications that occurred in connection with the separation from
Myriad Genetics, Myriad Genetics measured the potential accounting impact of these option modifications. Based upon the analysis, which included a comparison of the fair value of the modified options granted to our employees and directors
immediately after the modification with the fair value of the original option immediately prior to the modification, it was determined that there was no incremental compensation expense. All unrecognized compensation expense at June 30, 2009
that is related to Myriad Genetics options and Myrexis options that are held by current Myrexis employees and directors will be recognized by us over the remaining vesting term of the option. All such expense relating to Myrexis options held by
current and former Myriad Genetics employees, directors or consultants will not be recognized by us.

Recent Accounting Pronouncements

In January 2010, the Financial Accounting Standards Board issued Accounting Standards Update, or ASU, 2010-06, Improving
Disclosures about Fair Value Measurements. ASU 2010-06 requires additional disclosures about fair value measurements including transfers in and out of Levels 1 and 2 and a higher level of disaggregation for the different types of financial
instruments. For the reconciliation of Level 3 fair value measurements, information about purchases, sales, issuances and settlements are presented separately. This standard is effective for interim and annual reporting periods beginning after
December 15, 2009 with the exception of revised Level 3 disclosure requirements which are effective for interim and annual reporting periods beginning after December 15, 2010. Comparative disclosures are not required in the year of
adoption. We adopted the provisions of the standard on January 1, 2010, and the necessary disclosures are reflected in note 4 to the financial statements.

Results of Operations

The balance sheets as of June 30, 2010 and 2009, and notes related thereto reflect the balances of Myrexis as an independent company.
For all periods prior to June 30, 2010, amounts reflected in the results of operations are components of Myriad Genetics that constituted the research and drug development businesses that were separated. Those financial statements have been
prepared using Myriad Genetics historical costs basis of the assets and liabilities of the various activities that reflect the combined results of operations, financial condition and cash flows of us as a component of Myriad Genetics. Specific
costs attributable to our operations have been included in the financial statements. The financial statements also include some proportional cost allocations of certain common costs of Myriad Genetics because these expenses were not specifically
identified at the subsidiary level. The basis of these allocations includes full-time equivalent employees for the respective periods presented, square footage, and other appropriate allocation drivers.

The financial information for the year ended June 30, 2010 reflects the financial position, results of operations and cash flows for
Myrexis as a stand-alone entity. The financial information for the years ended June 30, 2009 and 2008 in the financial statements reflects allocations for services historically provided to us by Myriad Genetics and does not include all of the
expenses that would have been incurred had we been a separate, stand-alone publicly traded entity, including, but not limited to, costs to implement accounting, human resource, payroll, purchasing, information technology, legal and other business
functions and systems.

Years ended June 30, 2010 and 2009

Research revenue is comprised of research payments received pursuant to external collaborative agreements. Research revenue for the fiscal
year ended June 30, 2010 was $90,000 compared to $5.5 million in the prior year. The 98% decrease in research revenue was primarily attributable to a genomic sequencing research collaboration and a long-term contract that were completed during
the 2009 fiscal year. The Company anticipates research revenue to trend similar to fiscal 2010 in the future.



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Research and development expenses are comprised primarily of salaries and related personnel
costs, laboratory supplies, equipments costs, facilities expense, and costs associated with our clinical trials. Research and development expenses for the fiscal year ended June 30, 2010 were $28.2 million compared to $54.6 million in 2009.
This 48% decrease was primarily due to:



| |  |  | decreased internal preclinical developments costs of approximately $21.9 million resulting from reduction in headcount and other internal development
activities related to our former drug candidate Flurizan;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | decreased external drug candidate costs associated with our HIV drug candidate of $7.5 million due to the purchase of in process research and
development related to MPC-4326 and further development of this drug candidate; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | decreased external drug candidate costs associated with the discontinuation of MPC-9055 of $2.9 million.
| | - |  | --------------------------------------------------------------------------------------------------------

We expect our research and development expenses will fluctuate over the next several years as we conduct additional clinical trials to
support the potential commercialization of our drug candidates currently in clinical development, including Azixa and MPC-3100, and advance other drug candidates into clinical development.

Selling, general and administrative expenses consist primarily of salaries and related personnel costs for marketing, executive, legal,
finance and accounting, information technology, human resources, and allocated facilities expenses. Selling, general and administrative expenses for the fiscal year ended June 30, 2010 were $20.0 million, compared to $8.9 million in 2009. The
increase in selling, general and administrative expenses of 124% was due primarily to an increase in expenses associated with being a separate, stand-alone publicly traded entity, including, but not limited to, costs to implement accounting, human
resource, payroll, purchasing, information technology, legal and other business functions and systems. In addition to these certain costs, we incurred $3.1 million in external acquisition expenses in connection with the proposed merger with Javelin
Pharmaceuticals, Inc. that was terminated in April 2010. These expenses were offset by $1.5 million in stipulated expenses reimbursed by Javelin plus a termination fee of $2.9 million. These reimbursed expenses are presented in the financials for
the year ended June 30, 2010, as an offset to total selling, general and administrative costs. We expect our selling, general and administrative expenses will continue to fluctuate depending on our drug discovery and drug development efforts.

Other income (expense) for the fiscal year ended June 30, 2010 was $1.2 million compared to a $0.0 for the fiscal year
ended June 30, 2009. Other income reflects interest income and realized gains on our marketable securities offset by a loss on disposal of assets. Prior to June 30, 2009, all cash and investments were held and managed by Myriad Genetics
and, as a result, we recognized no interest income in our financial statements.

Years ended June 30, 2009 and 2008

Research and other revenue is comprised of research payments received pursuant to external collaborative agreements.
Research revenue for the fiscal year ended June 30, 2009 was $5.5 million compared to $6.8 million in the prior year. The 19% decrease in research revenue was primarily attributable to the completion of genomic sequencing research collaboration
in September 2008. Research revenue from our research collaboration agreements is recognized using a proportional performance methodology. Consequently, as these programs progress and outputs increase or decrease, revenue may increase or decrease
proportionately.

Pharmaceutical revenue is comprised of co-marketing agreement payments received relating to our former drug
candidate for the treatment of Alzheimers disease, Flurizan. On May 21, 2008, we entered into an agreement with Lundbeck for European commercialization of Flurizan. As consideration for entering into the agreement we received a $100.0
million non-refundable upfront fee which we expected to recognize over 15 years. On June 30, 2008, we announced the results of our U.S. 18-month Phase 3 clinical trial of Flurizan in patients with mild Alzheimers disease. The trial did
not achieve statistical significance on either of its primary



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endpoints, cognition and activities of daily living. As a result we discontinued all ongoing Flurizan clinical studies in 2008, including the decision to discontinue our global Phase 3 trial, and
have no further performance obligations under the agreement. The discontinuance of the Flurizan development program and any ongoing development activity related to Flurizan resulted in the recognition of the full $100.0 million upfront fee as
pharmaceutical revenue in fiscal 2008. In the fiscal year ended June 30, 2008, we recognized $104 million in pharmaceutical and other revenues relating to payments received under the agreement with Lundbeck. We had no pharmaceutical or other
revenue in fiscal 2009.

Research and development expenses are comprised primarily of salaries and related personnel costs,
laboratory supplies, equipments costs, facilities expense, and costs associated with our clinical trials. Research and development expenses for the fiscal year ended June 30, 2009 were $54.6 million compared to $121.5 million in 2008. This 55%
decrease was primarily due to:



| |  |  | decreased external drug development costs of approximately $76.0 million resulting from the discontinuance of our former drug candidate Flurizan that
includes a $9.0 million credit, recorded in fiscal 2009, resulting from the difference in an estimated sublicense fee accrual recorded in fiscal 2008 and amounts actually paid in 2009;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | increased external drug development costs associated with our HIV drug candidates of $9.2 million due to the purchase of in process research and
development related to MPC-4326 and further development of this drug candidate, which was offset by a $2.0 million decrease in expenditures relating to MPC-9055;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | increased external drug development costs of approximately $2.5 million and $1.3 million for MPC-3100 and Azixa, respectively, our oncology drug
candidates currently in clinical development; and
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | a decrease of approximately $2.9 million due to the completion of external research collaborations.
| | - |  | ---------------------------------------------------------------------------------------------------

We expect our research and development expenses will fluctuate over the next several years as we conduct additional clinical trials to
support the potential commercialization of our drug candidates currently in clinical development, including Azixa, MPC-3100, and advance other drug candidates into clinical development.

Selling, general and administrative expenses consist primarily of salaries and related personnel costs for marketing, executive, legal,
finance and accounting, information technology, human resources, and allocated facilities expenses. Selling, general and administrative expenses for the fiscal year ended June 30, 2009 were $9.0 million, compared to $20.6 million in 2008. The
decrease in selling, general and administrative expenses of 56% was due primarily to a decrease in commercialization efforts and internal expense allocations resulting from the discontinuance of our drug candidate Flurizan. We expect our selling,
general and administrative expenses will continue to fluctuate depending on our drug discovery and drug development efforts.

We had no other income (expense) for the fiscal year ended June 30, 2009 compared to a $3.0 million net expense for the fiscal year
ended June 30, 2008. This change was primarily attributable to the write-off of $3 million of our preferred stock investment in Encore Pharmaceuticals, Inc. (from whom we had previously licensed Flurizan) in 2008 as a result of our
discontinuation of our drug candidate Flurizan.

Liquidity and Capital Resources

Net cash used in operating activities was $40.4 million during the fiscal year ended June 30, 2010 compared to $60.7 million used by
operating activities during the prior fiscal year. The change in cash flow from operating activity can be attributed primarily to the higher net loss in fiscal 2009 and the payment of accrued expenses associated with the our former drug candidate
Flurizan. These were offset, in part, by higher non-cash charges associated with share-based compensation and the write-off of purchased in-process research and development recorded in fiscal 2009.



51



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Our investing activities used $54.4 million in cash during the fiscal year ended
June 30, 2010 compared to $7.4 million during the prior fiscal year. The change is primarily due to the purchase, net of maturities and selling of our marketable investment securities. In addition, we invested $2.1 million in capital
expenditures during the fiscal year ended June 30, 2010 in leasehold improvements, furniture and equipment for the new facility that we took occupancy of in January 2010. We anticipate our investment in additional equipment and leasehold
improvements will be minimal in the future.

Approximately $2.3 million in cash was provided by financing activities during
fiscal 2010, compared to $196.4 million during the prior fiscal year. Financing activities in fiscal 2010 were comprised primarily of cash proceeds from the exercise of stock awards. The change from fiscal 2009 to 2010 is primarily attributed to the
cash and Myriad Genetics net investment in Myrexis both of which were contributed to capital in connection with the spin-off in fiscal 2009. Prior to June 30, 2009, all cash and investments were held and managed by Myriad Genetics. Accordingly,
cash used to pay our expenses or cash collected from collaboration agreements was provided or received by Myriad Genetics on our behalf and were recorded as an increase or decrease in the Myriad Genetics net investment (capital deficiency).

As of June 30, 2010, we had $147.5 million in cash, cash equivalents and marketable securities, a decrease of $40.5
million from $188.0 million as of June 30, 2009. We believe that with our existing capital resources, we will have adequate funds to maintain our current and planned operations through at least June 30, 2013, although no assurance can be
given that changes will not occur that would consume available capital resources before such time and we may need or want to raise additional financing within this period of time. Our future capital requirements, cash flows, and results of
operations could be affected by and will depend on many factors that are currently unknown to us, including:



| |  |  | progress in and results from our clinical trials of Azixa and MPC-3100;
| | - |  | -----------------------------------------------------------------------



| |  |  | failure or delays in advancing our preclinical drug candidates, including MPC-9528, or other drug candidates we may develop in the future, into
clinical trials;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | results of clinical trials conducted by others on drugs that would compete with our drug candidates;
| | - |  | ----------------------------------------------------------------------------------------------------



| |  |  | issues in manufacturing our drug candidates or approved products;
| | - |  | -----------------------------------------------------------------



| |  |  | regulatory developments or enforcement in the United States and foreign countries;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | developments or disputes concerning patents or other proprietary rights;
| | - |  | ------------------------------------------------------------------------



| |  |  | introduction of technological innovations or new commercial products by us or our competitors;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | changes in estimates or recommendations by securities analysts, if any cover our common stock;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | failure to secure adequate capital to fund our operations if and when needed, or the issuance of equity securities at prices below the current market
price;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | public concern over our drug candidates or any approved products;
| | - |  | -----------------------------------------------------------------



| |  |  | litigation;
| | - |  | -----------



| |  |  | future sales of our common stock;
| | - |  | ---------------------------------



| |  |  | general market conditions;
| | - |  | --------------------------



| |  |  | changes in the structure of healthcare payment systems;
| | - |  | -------------------------------------------------------



| |  |  | failure of any of our drug candidates, if approved, to achieve commercial success;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | economic and other external factors or other disasters or crises;
| | - |  | -----------------------------------------------------------------



| |  |  | period-to-period fluctuations in our financial results; and
| | - |  | -----------------------------------------------------------



| |  |  | overall fluctuations in U.S. equity markets.
| | - |  | --------------------------------------------



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We may require significant additional funds earlier than we currently expect in order to
conduct additional clinical trials and conduct additional preclinical and discovery activities. Because of the numerous risks and uncertainties associated with the development and commercialization of our drug candidates, we are unable to estimate
the amounts of increased capital outlays and operating expenditures associated with our current and anticipated clinical trials.

To the extent our capital resources are insufficient to meet our future capital requirements, we will need to finance our future cash
needs through public or private equity offerings, collaboration agreements, debt financings or licensing arrangements. However, the credit markets and the financial services industry have recently been experiencing a period of unprecedented turmoil
and upheaval that have made equity and debt financing more difficult to obtain. Additional funding may not be available to us on acceptable terms or at all. In addition, the terms of any financing may adversely affect the holdings or the rights of
our stockholders. For example, if we raise additional funds by issuing equity securities or by selling convertible debt securities, further dilution to our existing stockholders may result. If we raise funds through collaboration agreements or
licensing arrangements, we may be required to relinquish rights to our technologies or drug candidates, or grant licenses on terms that are not favorable to us.

If adequate funds are not available, we may be required to terminate, significantly modify or delay our research and development
programs, reduce planned commercialization efforts, or obtain funds through collaborators that may require us to relinquish rights to our technologies or drug candidates that we might otherwise seek to develop or commercialize independently. We may
elect to raise additional funds even before we need them if the conditions for raising capital are favorable.

Off-Balance Sheet
Arrangements

None.

Contractual Obligations

The following table represents our contractual obligations as of June 30, 2010 (in thousands):



|                     |  |       |        |                   |   |           |  |           |       |                  |   |    |  |   |  
|-------------------- |  | ----- | ------ | ----------------- | - | --------- |  | --------- | ----- | ---------------- | - | -- |  | - | -
|                     |  | Total |        | Less thanone year |   | 1-3 Years |  | 4-5 Years |       | More than5 years
|Contractual services |  | $     | 2,430  |                   | $ | 1,937     |  | $         | 409   |                  | $ | 84 |  | $ | 
|Lease obligations    |  |       | 8,980  |                   |   | 3,476     |  |           | 5,504 |                  |   |   |  |   | 
|                     |  |       |        |                   |   |           |  |           |       |                  |   |    |  |   |  
|Total                |  | $     | 11,410 |                   | $ | 5,413     |  | $         | 5,913 |                  | $ | 84 |  | $ | 
|                     |  |       |        |                   |   |           |  |           |       |                  |   |    |  |   |  

Contractual services represent financial commitments
for drug development and clinical trial activities that can be terminated at our request. The expected timing of payment for the obligations listed above is estimated based on currently available information. The actual timing and amount of such
payments may differ depending on the timing of goods or services received and other factors. The table above only includes payment obligations that are fixed or determinable. The table excludes potential milestone payments we may be required to pay
under license agreements in the aggregate of up to $23 million based on the progress of our drug candidates currently in development, as the likelihood and timing of such payments is not yet determinable. The table also excludes royalties payable to
third parties based on future sales of any of our drug candidates that may be approved for sale in the future, as the amount, timing, and likelihood of any such payments are unknown.

Effects of Inflation

We
do not believe that inflation has had a material impact on our business, revenues, or operating results during the periods presented.



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|Item 7A. | QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
|-------- | ----------------------------------------------------------

We maintain a portfolio of cash, cash equivalents and short term and long term marketable securities which are subject to interest rate
risk. Our investments consist primarily of highly liquid securities of various types and maturities of two years or less, with a maximum average maturity of 12 months. Changes in interest rates affect the fair market value of these marketable
investment securities. After a review of our marketable securities as of June 30, 2010 and 2009, we have determined, hypothetically, that in the event of an increase of 100 basis points in a key market interest rate, the resulting decrease in
fair market value of our marketable investment securities would not have a material effect on our financial condition or on our financial statements as a whole.



|Item 8. | FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA
|------- | -------------------------------------------

The information required by this Item 8 is included at the end of this Annual Report on Form 10-K beginning on page F-1.

MYREXIS, INC.



|                                                                                                                     |  |       
|-------------------------------------------------------------------------------------------------------------------- |  | ------
|Index to Financial Statements                                                                                        |  | Number
|Report of Independent Registered Public Accounting Firm                                                              |  | F-2   
|Balance Sheets as of June 30, 2010 and 2009                                                                          |  | F-3   
|Statements of Operations for the Years Ended June 30, 2010, 2009 and 2008                                            |  | F-4   
|Statements of Stockholders Equity and Comprehensive Income (Loss) for the Years Ended June 
30, 2010, 2009 and 2008 |  | F-5   
|Statements of Cash Flows for the Years Ended June 30, 2010, 2009 and 2008                                            |  | F-6   
|Notes to Financial Statements                                                                                        |  | F-7   



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|Item 9. | CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE
|------- | ------------------------------------------------------------------------------------

Not applicable.



|Item 9A. | CONTROLS AND PROCEDURES
|-------- | -----------------------

1. Disclosure
Controls and Procedures

We maintain disclosure controls and procedures (Disclosure Controls) within the meaning of Rules
13a-15(e) and 15d-15(e) of the Securities Exchange Act of 1934, as amended, or the Exchange Act. Our Disclosure Controls are designed to ensure that information required to be disclosed by us in the reports we file or submit under the Exchange Act,
such as this Annual Report on Form 10-K, is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commissions rules and forms. Our Disclosure Controls are also designed to ensure that
such information is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure.

Our Chief Executive Officer and Chief Financial Officer, after evaluating the effectiveness of our Disclosure Controls as of the end of
the period covered by this Annual Report on Form 10-K, have concluded that, based on such evaluation, our Disclosure Controls were effective to ensure that information required to be disclosed by us in the reports that we file or submit under the
Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SECs rules and forms, and is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial
Officer, or persons performing similar functions, as appropriate to allow timely decisions regarding required disclosure.

2. Internal
Control Over Financial Reporting

(a) Managements Annual Report on Internal Control over Financial Reporting

Our management is responsible for establishing and maintaining adequate internal control over financial reporting.
Internal control over financial reporting is defined in Rules 13a-15(f) and 15d-15(f) promulgated under the Exchange Act as a process designed by, or under the supervision of, a companys principal executive and principal financial officers and
effected by the companys board of directors, management and other personnel to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with
U.S. generally accepted accounting principles. A companys internal control over financial reporting includes those policies and procedures that:



| |  |  | pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the
company;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally
accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the companys assets that
could have a material effect on the financial statements.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Because of those inherent limitations, internal
control over financial reporting may not prevent or detect misstatements. Our management assessed the effectiveness of our internal control over financial reporting as of June 30, 2010. In making their assessment, management used the criteria
set forth by the Committee of Sponsoring Organizations of the Treadway Commission (COSO) in Internal Control  Integrated Framework.Based on our assessment, management believes that, as of June 30, 2010, our internal control over
financial reporting is effective based on those criteria.

Our independent registered public accounting firm has issued its
report on the effectiveness of our internal control over financial reporting. This report appears below.



55



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##### Table of Contents

(b) Attestation Report of the Registered Public Accounting Firm

Report of Independent Registered Public Accounting Firm

The Board of Directors and Stockholders

Myrexis, Inc.

We have
audited Myrexis, Inc.s internal control over financial reporting as of June 30, 2010, based on criteria established in Internal ControlIntegrated Framework issued by the Committee of Sponsoring Organizations of the Treadway
Commission (the COSO criteria). Myrexis, Inc.s management is responsible for maintaining effective internal control over financial reporting, and for its assessment of the effectiveness of internal control over financial reporting included in
the accompanying Managements Annual Report on Internal Control over Financial Reporting. Our responsibility is to express an opinion on the companys internal control over financial reporting based on our audit.

We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards
require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control
over financial reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered
necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.

A companys
internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted
accounting principles. A companys internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions
and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that
receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized
acquisition, use, or disposition of the companys assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections
of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

In our opinion, Myrexis, Inc. maintained, in all material respects, effective internal control over financial reporting as of
June 30, 2010, based on the COSO criteria.

We also have audited, in accordance with the standards of the Public Company
Accounting Oversight Board (United States), the balance sheets of Myrexis, Inc. as of June 30, 2010 and 2009, and the related statements of operations, stockholders equity and comprehensive income (loss), and cash flows for each of the
three years in the period ended June 30, 2010, and our report dated September 13, 2010 expressed an unqualified opinion thereon.

/s/ Ernst & Young LLP

Salt Lake
City, Utah

September 13, 2010



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##### Table of Contents

(c) Change in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting, identified in connection with the evaluation of such internal
control that occurred during the fourth quarter of our last fiscal year that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.



|Item 9B. | OTHER INFORMATION
|-------- | -----------------

Not
applicable.



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##### Table of Contents

PART III



|Item 10. | DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE
|-------- | ------------------------------------------------------

The response to this item is incorporated by reference from the discussion responsive thereto under the captions Management and
Corporate Governance, Section 16(a) Beneficial Ownership Reporting Compliance and Code of Conduct and Ethics in our Proxy Statement for the 2010 Annual Meeting of Stockholders to be held on November 11, 2010.



|Item 11. | EXECUTIVE COMPENSATION
|-------- | ----------------------

The response to this item is incorporated by reference from the discussion responsive thereto under the captions Compensation
Discussion and Analysis, Executive Officer and Director Compensation, Management and Corporate Governance-Committees of the Board of Directors and Meetings, Management and Corporate Governance-Compensation
Committee Interlocks and Insider Participation, Compensation Committee Report and Risks Related to Compensation Practices and Policies in our Proxy Statement for the 2010 Annual Meeting of Stockholders to be held on
November 11, 2010.



58



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##### Table of Contents

|Item 12. | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS
|-------- | ----------------------------------------------------------------------------------------------

The response to this item is incorporated by reference from the discussion responsive thereto under the captions Security Ownership
of Certain Beneficial Owners and Management and Equity Compensation Plan Information in our Proxy Statement for the 2010 Annual Meeting of Stockholders to be held on November 11, 2010.



|Item 13. | CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE
|-------- | -------------------------------------------------------------------------

The response to this item is incorporated by reference from the discussion responsive thereto under the captions Certain
Relationships and Related Person Transactions and Management and Corporate Governance-Director Independence in our Proxy Statement for the 2010 Annual Meeting of Stockholders to be held on November 11, 2010.



|Item 14. | PRINCIPAL ACCOUNTANT FEES AND SERVICES
|-------- | --------------------------------------

The response to this item is incorporated by reference to the discussion responsive thereto in the proposal entitled Independent
Registered Public Accounting Firm in our Proxy Statement for the 2010 Annual Meeting of Stockholders to be held on November 11, 2010.



59



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##### Table of Contents

PART IV



|Item 15. | EXHIBITS AND FINANCIAL STATEMENT SCHEDULES
|-------- | ------------------------------------------

(a)The following documents are filed as part of this Annual Report on Form 10-K:

1. Financial Statements

See Index to Financial Statements at Item 8 of this Annual Report on Form 10-K.

2. Financial Statement Schedules

The financial statements beginning on page F-1 are filed as part of this Annual Report on Form 10-K. Other financial
statement schedules have not been included because they are not applicable or the information is included in the financial statements or notes thereto.

3. Exhibits

The exhibits which are filed with or incorporated by reference into this Annual Report on Form 10-K are set forth in the
Exhibit Index to this Annual Report on Form 10-K, which is incorporated herein by reference.



60



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##### Table of Contents

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant has duly caused this
report to be signed on its behalf by the undersigned, thereunto duly authorized, on September 13, 2010.



MYREXIS, INC.By:

/S/    ADRIAN N.
HOBDENAdrian N. Hobden, Ph.D.President and Chief Executive Officer


Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf
of the Registrant and in the capacities indicated below and on the dates indicated.



|    |  |                              |  |                                                    |  |                   
|--- |  | ---------------------------- |  | -------------------------------------------------- |  | ------------------
|    |  | Signatures                   |  | Title                                              |  | Date              
|By: |  | /s/    ADRIAN N.
HOBDEN      |  | President, Chief Executive                         |  | September 13, 2010
|    |  | Adrian N. Hobden, Ph.D.      |  | Officer and Director
(principal executive officer) |  |                   
|    |  |                              | 
|By: |  | /s/    ROBERT J.
LOLLINI     |  | Chief Financial Officer                            |  | September 13, 2010
|    |  | Robert J. Lollini            |  | (principal financial and
accounting officer)       |  |                   
|    |  |                              | 
|By: |  | /s/    GERALD P.
BELLE       |  | Chairman of the Board                              |  | September 13, 2010
|    |  | Gerald P. Belle              |  |                                                    |  |                   
|    |  |                              | 
|By: |  | /s/    JOHN T.
HENDERSON     |  | Director                                           |  | September 13, 2010
|    |  | John T. Henderson, M.D.      |  |                                                    |  |                   
|    |  |                              | 
|By: |  | /s/    DENNIS H.
LANGER      |  | Director                                           |  | September 13, 2010
|    |  | Dennis H. Langer, M.D., J.D. |  |                                                    |  |                   
|    |  |                              | 
|By: |  | /s/    ROBERT
FORRESTER      |  | Director                                           |  | September 13, 2010
|    |  | Robert Forrester             |  |                                                    |  |                   
|    |  |                              | 
|By: |  | /s/    TIMOTHY R.
FRANSON    |  | Director                                           |  | September 13, 2010
|    |  | Timothy R. Franson, M.D.     |  |                                                    |  |                   



61



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##### Table of Contents

INDEX TO FINANCIAL STATEMENTS

Myrexis, Inc.

Years Ended June 30, 2010, 2009 and 2008



|                                                                                                                     |  |     
|-------------------------------------------------------------------------------------------------------------------- |  | ----
|                                                                                                                     |  | Page
|Report of Independent Registered Public Accounting Firm                                                              |  | F-2 
|                                                                                                                     | 
|Financial Statements:                                                                                                |  |     
|Balance Sheets as of June 30, 2010 and 2009                                                                          |  | F-3 
|Statements of Operations for the Years Ended June 30, 2010, 2009 and 2008                                            |  | F-4 
|Statements of Stockholders Equity and Comprehensive Income (Loss) for the Years Ended June 
30, 2010, 2009 and 2008 |  | F-5 
|Statements of Cash Flows for the Years Ended June 30, 2010, 2009 and 2008                                            |  | F-6 
|Notes to Financial Statements                                                                                        |  | F-7 



F-1



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##### Table of Contents

Report of Independent Registered Public
Accounting Firm

The Board of Directors and Stockholders

Myrexis, Inc.

We have audited
the accompanying balance sheets of Myrexis, Inc. as of June 30, 2010 and 2009, and the related statements of operations, stockholders equity and comprehensive income (loss), and cash flows for each of the three years in the period ended
June 30, 2010. These financial statements are the responsibility of the Companys management. Our responsibility is to express an opinion on these financial statements based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those
standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and
disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits
provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all
material respects, the financial position of Myrexis, Inc. at June 30, 2010 and 2009, and the results of its operations and its cash flows for each of the three years in the period ended June 30, 2010, in conformity with U.S. generally
accepted accounting principles.

We also have audited, in accordance with the standards of the Public Company Accounting
Oversight Board (United States), Myrexis, Inc.s internal control over financial reporting as of June 30, 2010, based on criteria established in Internal Control-Integrated Framework issued by the Committee of Sponsoring Organizations of
the Treadway Commission and our report dated September 13, 2010 expressed an unqualified opinion thereon.

/s/ Ernst & Young LLP

Salt Lake City, Utah

September 13, 2010



F-2



---

##### Table of Contents

MYREXIS, INC.

Balance Sheets

June 30, 2010 and 2009

(In thousands, except per share amounts)



|                                                                                                                                                                      |  |      |         |   |      |   |        
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ---- | ------- | - | ---- | - | -------
|                                                                                                                                                                      |  | 2010 |         |   | 2009
|Assets                                                                                                                                                                |  |      |         |   |      |   |        
|Current assets:                                                                                                                                                       |  |      |         |   |      |   |        
|Cash and cash equivalents                                                                                                                                             |  | $    | 35,911  |   |      | $ | 128,372
|Marketable investment securities                                                                                                                                      |  |      | 102,965 |   |      |   | 40,728 
|Prepaid expenses and other assets                                                                                                                                     |  |      | 453     |   |      |   | 240    
|                                                                                                                                                                      |  |      |         |   |      |   |        
|Total current assets                                                                                                                                                  |  |      | 139,329 |   |      |   | 169,340
|                                                                                                                                                                      |  |      |         |   |      |   |        
|Equipment and leasehold improvements:                                                                                                                                 |  |      |         |   |      |   |        
|Equipment                                                                                                                                                             |  |      | 6,035   |   |      |   | 5,338  
|Leasehold improvements                                                                                                                                                |  |      | 1,160   |   |      |   |       
|                                                                                                                                                                      |  |      |         |   |      |   |        
|                                                                                                                                                                      |  |      | 7,195   |   |      |   | 5,338  
|Less accumulated depreciation                                                                                                                                         |  |      | 1,199   |   |      |   |       
|                                                                                                                                                                      |  |      |         |   |      |   |        
|Net equipment and leasehold improvements                                                                                                                              |  |      | 5,996   |   |      |   | 5,338  
|                                                                                                                                                                      |  |      |         |   |      |   |        
|Long-term marketable investment securities                                                                                                                            |  |      | 8,577   |   |      |   | 18,905 
|Other assets                                                                                                                                                          |  |      | 206     |   |      |   | 94     
|                                                                                                                                                                      |  |      |         |   |      |   |        
|Total assets                                                                                                                                                          |  | $    | 154,108 |   |      | $ | 193,677
|                                                                                                                                                                      |  |      |         |   |      |   |        
|Liabilities and Stockholders Equity                                                                                                                                  |  |      |         |   |      |   |        
|Current liabilities:                                                                                                                                                  |  |      |         |   |      |   |        
|Accounts payable                                                                                                                                                      |  | $    | 1,927   |   |      | $ |       
|Accrued liabilities                                                                                                                                                   |  |      | 2,323   |   |      |   | 4,576  
|                                                                                                                                                                      |  |      |         |   |      |   |        
|Total current liabilities                                                                                                                                             |  |      | 4,250   |   |      |   | 4,576  
|                                                                                                                                                                      |  |      |         |   |      |   |        
|Commitments and contingencies                                                                                                                                         |  |      |         |   |      |   |        
|Stockholders equity:                                                                                                                                                 |  |      |         |   |      |   |        
|Preferred stock, $0.01 par value, authorized 5,000 shares; no shares issued and outstanding                                                                           |  |      |        |   |      |   |       
|Common stock, $0.01 par value, authorized 60,000 shares; issued and outstanding 25,214 shares at June 30, 2010; issued and
outstanding 23,974 shares at June 30, 2009 |  |      | 252     |   |      |   | 240    
|Additional paid-in capital                                                                                                                                            |  |      | 196,532 |   |      |   | 188,400
|Accumulated other comprehensive income                                                                                                                                |  |      | 25      |   |      |   | 461    
|Accumulated deficit                                                                                                                                                   |  |      | (46,951 | ) |      |   |       
|                                                                                                                                                                      |  |      |         |   |      |   |        
|Total stockholders equity                                                                                                                                            |  |      | 149,858 |   |      |   | 189,101
|                                                                                                                                                                      |  |      |         |   |      |   |        
|Total liabilities and stockholders equity                                                                                                                            |  | $    | 154,108 |   |      | $ | 193,677
|                                                                                                                                                                      |  |      |         |   |      |   |        









See accompanying notes to financial statements.



F-3



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##### Table of Contents

MYREXIS, INC.

Statements of Operations

Years ended June 30, 2010, 2009 and 2008

(In thousands, except per share amounts)



|                                                                             |  |      |         |   |      |   |         |      |  |   |         |     
|---------------------------------------------------------------------------- |  | ---- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | ----
|                                                                             |  | 2010 |         |   | 2009 |   |         | 2008 | 
|Research revenue                                                             |  | $    | 90      |   |      | $ | 5,456   |      |  | $ | 6,774   |     
|Pharmaceutical revenue                                                       |  |      |        |   |      |   |        |      |  |   | 100,000 |     
|Other revenue                                                                |  |      |        |   |      |   |        |      |  |   | 4,000   |     
|                                                                             |  |      |         |   |      |   |         |      |  |   |         |     
|Total revenue                                                                |  |      | 90      |   |      |   | 5,456   |      |  |   | 110,774 |     
|                                                                             |  |      |         |   |      |   |         |      |  |   |         |     
|Costs and expenses:                                                          |  |      |         |   |      |   |         |      |  |   |         |     
|Research and development expense                                             |  |      | 28,222  |   |      |   | 54,611  |      |  |   | 121,526 |     
|Selling, general, and administrative expense                                 |  |      | 19,984  |   |      |   | 8,981   |      |  |   | 20,600  |     
|                                                                             |  |      |         |   |      |   |         |      |  |   |         |     
|Total costs and expenses                                                     |  |      | 48,206  |   |      |   | 63,592  |      |  |   | 142,126 |     
|                                                                             |  |      |         |   |      |   |         |      |  |   |         |     
|Operating loss                                                               |  |      | (48,116 | ) |      |   | (58,136 | )    |  |   | (31,352 | )   
|                                                                             |  |      |         |   |      |   |         |      |  |   |         |     
|Other income (expense), net                                                  |  |      | 1,165   |   |      |   |        |      |  |   | (3,017  | )   
|                                                                             |  |      |         |   |      |   |         |      |  |   |         |     
|Net loss                                                                     |  | $    | (46,951 | ) |      | $ | (58,136 | )    |  | $ | (34,369 | )   
|                                                                             |  |      |         |   |      |   |         |      |  |   |         |     
|Loss per basic and diluted share                                             |  | $    | (1.91   | ) |      | $ | (2.43   | )(1) |  |   | (1.43   | )(1)
|Weighted-average shares used to compute net loss per basic and diluted share |  |      | 24,545  |   |      |   | 23,974  | (2)  |  |   | 23,974  | (2) 



|(1) | Pro forma loss per basic and diluted share for fiscal years ended June 30, 2009 and 2008.
|--- | -----------------------------------------------------------------------------------------



|(2) | Pro forma shares used to compute net loss per basic and diluted share for years ended June 30, 2009 and 2008.
|--- | -------------------------------------------------------------------------------------------------------------





See accompanying notes to financial statements.



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MYREXIS, INC.

Statements of Stockholders Equity and Comprehensive Income (Loss)

Years ended June 30, 2010, 2009 and 2008

(In thousands)



|                                                                                                                                    |  |              |  |                          |     |                    |   |         |                                                     |   |         |                         |  |   |                          |   |  |   |          |   |  |   |         |  
|----------------------------------------------------------------------------------------------------------------------------------- |  | ------------ |  | ------------------------ | --- | ------------------ | - | ------- | --------------------------------------------------- | - | ------- | ----------------------- |  | - | ------------------------ | - |  | - | -------- | - |  | - | ------- | -
|                                                                                                                                    |  | Common Stock |  | AdditionalPaid-InCapital |     | AccumulatedDeficit |   |         | Unrealized(Loss)Gain onAvailable-for-salesecurities |   |         | ParentCompanyInvestment |  |   | TotalStockholdersEquity |  
|                                                                                                                                    |  | Shares       |  | Amount                   |     |                    |   |         |                                                    
|Balance at June 30, 2007                                                                                                            |  |             |  | $                        |    |                    | $ |        |                                                     | $ |        |                         |  | $ |                         |   |  | $ | 5,369    |   |  | $ | 5,369   |  
|Net transfers from parent                                                                                                           |  |             |  |                          |    |                    |   |        |                                                     |   |        |                         |  |   |                         |   |  |   | (1,822   | ) |  |   | (1,822  | )
|Net loss                                                                                                                            |  |             |  |                          |    |                    |   |        |                                                     |   |        |                         |  |   |                         |   |  |   | (34,369  | ) |  |   | (34,369 | )
|                                                                                                                                    |  |              |  |                          |     |                    |   |         |                                                     |   |         |                         |  |   |                          |   |  |   |          |   |  |   |         |  
|Balance at June 30, 2008                                                                                                            |  |             |  |                          |    |                    |   |        |                                                     |   |        |                         |  |   |                         |   |  |   | (30,822  | ) |  |   | (30,822 | )
|Net transfers from parent                                                                                                           |  |             |  |                          |    |                    |   |        |                                                     |   |        |                         |  |   |                         |   |  |   | 90,054   |   |  |   | 90,054  |  
|Contribution of cash and investments from parent                                                                                    |  |             |  |                          |    |                    |   |        |                                                     |   |        |                         |  |   | 461                      |   |  |   | 187,544  |   |  |   | 188,005 |  
|Contribution of net operating assets and liabilities to Myrexis, Inc. and issuance of common shares to Myriad Genetics
stockholders |  | 23,974       |  |                          | 240 |                    |   | 188,400 |                                                     |   |        |                         |  |   |                         |   |  |   | (188,640 | ) |  |   |        |  
|Net loss and comprehensive loss                                                                                                     |  |             |  |                          |    |                    |   |        |                                                     |   |        |                         |  |   |                         |   |  |   | (58,136  | ) |  |   | (58,136 | )
|                                                                                                                                    |  |              |  |                          |     |                    |   |         |                                                     |   |         |                         |  |   |                          |   |  |   |          |   |  |   |         |  
|Balance at June 30, 2009                                                                                                            |  | 23,974       |  |                          | 240 |                    |   | 188,400 |                                                     |   |         |                         |  |   | 461                      |   |  |   |         |   |  |   | 189,101 |  
|Comprehensive Income:                                                                                                               |  |              |  |                          |     |                    |   |         |                                                     |   |         |                         |  |   |                          |   |  |   |          |   |  |   |         |  
|Net loss                                                                                                                            |  |             |  |                          |    |                    |   |        |                                                     |   | (46,951 | )                       |  |   |                         |   |  |   |         |   |  |   | (46,951 | )
|Change in unrealized gains on marketable investment securities                                                                      |  |             |  |                          |    |                    |   |        |                                                     |   |        |                         |  |   | (436                     | ) |  |   |         |   |  |   | (436    | )
|                                                                                                                                    |  |              |  |                          |     |                    |   |         |                                                     |   |         |                         |  |   |                          |   |  |   |          |   |  |   |         |  
|Total comprehensive loss                                                                                                            |  |              |  |                          |     |                    |   |         |                                                     |   |         |                         |  |   |                          |   |  |   |          |   |  |   | (47,387 | )
|Issuance of common stock for cash upon exercise of options and employee stock purchase plan                                         |  | 1,240        |  |                          | 12  |                    |   | 2,332   |                                                     |   |        |                         |  |   |                         |   |  |   |         |   |  |   | 2,344   |  
|Share-based payment expense                                                                                                         |  |             |  |                          |    |                    |   | 5,800   |                                                     |   |        |                         |  |   |                         |   |  |   |         |   |  |   | 5,800   |  
|                                                                                                                                    |  |              |  |                          |     |                    |   |         |                                                     |   |         |                         |  |   |                          |   |  |   |          |   |  |   |         |  
|Balance at June 30, 2010                                                                                                            |  | 25,214       |  | $                        | 252 |                    | $ | 196,532 |                                                     | $ | (46,951 | )                       |  | $ | 25                       |   |  |   |         |   |  | $ | 149,858 |  
|                                                                                                                                    |  |              |  |                          |     |                    |   |         |                                                     |   |         |                         |  |   |                          |   |  |   |          |   |  |   |         |  



See accompanying notes to financial
statements.



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##### Table of Contents

MYREXIS, INC.

Statements of Cash Flows

Years ended June 30, 2010, 2009 and 2008

(In thousands)



|                                                                                           |  |      |          |   |      |   |         |      |  |   |         |  
|------------------------------------------------------------------------------------------ |  | ---- | -------- | - | ---- | - | ------- | ---- |  | - | ------- | -
|                                                                                           |  | 2010 |          |   | 2009 |   |         | 2008 | 
|Cash flows from operating activities:                                                      |  |      |          |   |      |   |         |      |  |   |         |  
|Net loss                                                                                   |  | $    | (46,951  | ) |      | $ | (58,136 | )    |  | $ | (34,369 | )
|Adjustments to reconcile net loss to net cash provided by (used in) operating activities:  |  |      |          |   |      |   |         |      |  |   |         |  
|Depreciation and amortization                                                              |  |      | 1,347    |   |      |   | 2,854   |      |  |   | 3,214   |  
|Loss on disposition of assets                                                              |  |      | 224      |   |      |   |        |      |  |   | 17      |  
|Share-based compensation expense                                                           |  |      | 5,800    |   |      |   | 10,445  |      |  |   | 7,807   |  
|Loss on cost-basis investment                                                              |  |      |         |   |      |   |        |      |  |   | 3,000   |  
|Gain on sale of marketable investment securities                                           |  |      | (43      | ) |      |   |        |      |  |   |        |  
|Write-off in process research and development                                              |  |      |         |   |      |   | 7,000   |      |  |   |        |  
|Changes in operating assets and liabilities:                                               |  |      |          |   |      |   |         |      |  |   |         |  
|Prepaid expenses                                                                           |  |      | (213     | ) |      |   | 390     |      |  |   | 117     |  
|Accounts receivable                                                                        |  |      |         |   |      |   | 4,547   |      |  |   | (3,299  | )
|Other assets, long-term                                                                    |  |      | (206     | ) |      |   |        |      |  |   |        |  
|Due to parent                                                                              |  |      |         |   |      |   |        |      |  |   | 7,163   |  
|Accounts payable                                                                           |  |      | 1,927    |   |      |   |        |      |  |   |        |  
|Accrued liabilities                                                                        |  |      | (2,253   | ) |      |   | (25,782 | )    |  |   | 26,880  |  
|Deferred revenue                                                                           |  |      |         |   |      |   | (2,000  | )    |  |   | 1,650   |  
|                                                                                           |  |      |          |   |      |   |         |      |  |   |         |  
|Net cash provided by (used in) operating activities                                        |  |      | (40,368  | ) |      |   | (60,682 | )    |  |   | 12,180  |  
|                                                                                           |  |      |          |   |      |   |         |      |  |   |         |  
|Cash flows from investing activities:                                                      |  |      |          |   |      |   |         |      |  |   |         |  
|Capital expenditures for equipment and leasehold improvements                              |  |      | (2,135   | ) |      |   | (375    | )    |  |   | (2,332  | )
|Acquisition of in-process research and development                                         |  |      |         |   |      |   | (7,000  | )    |  |   |        |  
|Purchase of marketable investment securities                                               |  |      | (183,876 | ) |      |   |        |      |  |   |        |  
|Proceeds from sale of marketable investment securities                                     |  |      | 32,794   |   |      |   |        |      |  |   |        |  
|Proceeds from maturity of marketable investment securities                                 |  |      | 98,779   |   |      |   |        |      |  |   |        |  
|Change in other assets                                                                     |  |      |         |   |      |   |        |      |  |   | (219    | )
|                                                                                           |  |      |          |   |      |   |         |      |  |   |         |  
|Net cash used in investing activities                                                      |  |      | (54,438  | ) |      |   | (7,375  | )    |  |   | (2,551  | )
|                                                                                           |  |      |          |   |      |   |         |      |  |   |         |  
|Cash flows from financing activities:                                                      |  |      |          |   |      |   |         |      |  |   |         |  
|Net proceeds from common stock issued under share-based compensation plans                 |  |      | 2,345    |   |      |   |        |      |  |   |        |  
|Net change in investment from parent                                                       |  |      |         |   |      |   | 196,429 |      |  |   | (9,629  | )
|                                                                                           |  |      |          |   |      |   |         |      |  |   |         |  
|Net cash provided by (used in) financing activities                                        |  |      | 2,345    |   |      |   | 196,429 |      |  |   | (9,629  | )
|                                                                                           |  |      |          |   |      |   |         |      |  |   |         |  
|Net increase (decrease) in cash and cash equivalents                                       |  |      | (92,461  | ) |      |   | 128,372 |      |  |   |        |  
|Cash and cash equivalents at beginning of year                                             |  |      | 128,372  |   |      |   |        |      |  |   |        |  
|                                                                                           |  |      |          |   |      |   |         |      |  |   |         |  
|Cash and cash equivalents at end of year                                                   |  | $    | 35,911   |   |      | $ | 128,372 |      |  | $ |        |  
|                                                                                           |  |      |          |   |      |   |         |      |  |   |         |  
|Supplemental cash flow information:                                                        |  |      |          |   |      |   |         |      |  |   |         |  
|Fair value adjustment on marketable investment securities recorded to stockholders equity |  |      | (436     | ) |      |   | 461     |      |  |   |        |  

See accompanying notes
to financial statements.



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MYREXIS, INC.

Notes to Financial Statements

June 30, 2010, 2009, and 2008



|(1) | Organization and Summary of Significant Accounting Policies
|--- | -----------------------------------------------------------



| | (a) | Organization and Business Description
| | --- | -------------------------------------

Myrexis, Inc. (Myrexis or the Company) is a biotechnology company focused on discovering,
developing and commercializing novel treatments for cancer. The Companys pipeline includes clinical and preclinical product candidates with distinct mechanisms of action and novel chemical structures that have the potential to be
first-in-class and/or best-in-class therapeutics. The discovery and development of each of the Companys drug candidates has been guided by a unique understanding of the genetic causes of human diseases, the genetic factors that may cause drug
side effects, drug interactions, and drug metabolism. The Companys extensive experience in human genetics, protein-protein interaction technology and chemical proteomic drug discovery has allowed identification of novel drug targets and
accelerated progression from chemical lead compounds to investigational drug candidates.

On June 2, 2009
the Myriad Genetics, Inc. (MGI) Board of Directors approved a plan to separate its molecular diagnostic business from its research and drug development businesses. In order to carry out the proposed separation of the research and drug
development businesses MGI created a new wholly owned subsidiary, a Delaware corporation into which the research operations along with substantially all of the assets (and employees) of the pharmaceuticals business and associated intellectual
property rights (including patents) and cash were contributed. In connection with the formation of this new subsidiary, MGIs existing subsidiary, Myriad Pharmaceuticals, Inc., changed its corporate name to Myriad Therapeutics, Inc., and the
newly formed subsidiary adopted the name of Myriad Pharmaceuticals, Inc., and, effective July 1, 2010, changed its name to Myrexis, Inc.

The shares of Myrexis were distributed on June 30, 2009 to MGI stockholders of record as of June 17, 2009 as a
pro-rata, tax-free dividend. MGI has received a private letter ruling from the Internal Revenue Service affirming the tax-free nature of the spin-off. The separation resulted in Myrexis operating as an independent entity with its own publicly traded
common stock. MGI no longer has any ownership or other form of interest in Myrexis subsequent to the separation. Following the separation, the Companys operations consist solely of the operations described herein.

In connection with the separation, Myrexis and MGI entered into a series of agreements, including a separation agreement,
a sublease agreement, an employee matters agreement, and a tax sharing agreement. See note 2 for further discussion regarding these agreements.

The Companys focus is to discover and develop therapeutic products to treat patients with unmet medical needs.
Myrexis researchers have made important discoveries that point to novel disease pathways that may pave the way for the development of new classes of drugs. The Companys operations are located in Salt Lake City, Utah.



| | (b) | Basis of Accounting
| | --- | -------------------

The balance sheets as of June 30, 2010 and 2009 and notes related thereto, reflect the balances of Myrexis as an
independent company. For periods prior to June 30, 2009, the amounts reflected in the financial statements include the assets, liabilities and results of operations of the components of MGI that constitute the drug development and research
businesses that were separated. The accompanying financial statements for periods prior to June 30, 2009, have been prepared using MGIs historical costs basis of the assets and liabilities of the various activities that reflect the
combined results of operations, financial condition and cash flows of Myrexis as a component of MGI. For purposes of preparing the statements of operations for the years ended June 30, 2009 and 2008, Myrexis has been allocated



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##### Table of Contents

certain expenses from MGI but has not been allocated the underlying productive assets, such as, certain information systems equipment that will not be assigned to Myrexis but for which Myrexis
has benefited from the assets. Such expenses have been reflected in the statements of operations as expense allocations from MGI for those periods.

Management believes that the assumptions underlying the financial statements for years ended prior to June 30, 2010,
are reasonable. The financial information in those financial statements does not include all expenses that would have been incurred had Myrexis been an independent publicly traded entity. As such, the financial information herein does not reflect
the financial position, results of operations or cash flows of Myrexis in the future or what they would have been, had Myrexis been a separate, stand-alone entity during the periods presented. Specific costs attributable to Myrexis operations have
been included in Myrexis Inc.s financial statements. The financial statements also include some proportional cost allocations of certain common costs of MGI and Myrexis because these expenses were not specifically identified at the subsidiary
level. The basis of these allocations includes full-time equivalent employees for the respective periods presented, square footage, and other appropriate allocation drivers.



| | (c) | Use of Estimates
| | --- | ----------------

The preparation of the financial statements in accordance with U.S. generally accepted accounting principles requires
Myrexis management to make estimates and assumptions relating to the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and
expenses during the period. Significant items subject to such estimates and assumptions include the carrying amount of certain accrued liabilities and share-based compensation. Actual results could differ from those estimates presented herein.



| | (d) | Cash and Cash Equivalents
| | --- | -------------------------

The Company considers all cash on deposit, money market accounts, and highly liquid debt instruments purchased with
original maturities of three months or less to be cash and cash equivalents. The Company maintains cash and cash equivalents in bank deposit and other investment accounts which, at times, may exceed federally insured limits.



| | (e) | Myriad Genetics, Inc. Net Investment (Capital Deficiency)
| | --- | ---------------------------------------------------------

The balance sheet as of June 30, 2010 and 2009 reflects the balances of Myrexis as an independent company. Amounts
reflected in the statements of operations of Myrexis for the years ended June 30, 2009 and 2008, represent a combination of various components of MGI. The statement of operations for the year ended June 30, 2010 is representative of
Myrexis as a stand-alone company. Because a direct ownership relationship did not exist among all the components comprising Myrexis, MGIs investment in Myrexis is shown in lieu of stockholders equity in the financial statements for
periods prior to June 30, 2009. The net investment account represents the cumulative investments in, distributions from and earnings (loss) of Myrexis.

Prior to June 30, 2009, Myrexis had certain liabilities classified as due to parent that represent accounts payable
by Myrexis to third parties that MGI paid on behalf of Myrexis. As MGI had not paid these Myrexis accounts payable as of the balance sheet dates, those amounts have been recorded as accounts payable due to parent in the financial statements.

Prior to the spin-off all cash and investments were held and managed by MGI. Accordingly, cash used to pay
Myrexis expenses or cash collected from collaboration agreements by MGI on behalf of Myrexis prior to June 30, 2009 are recorded as an increase or decrease in the MGI net investment (capital deficiency).



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| | (f) | Loss Per Share
| | --- | --------------

The loss per basic and diluted share is calculated by dividing net loss by the weighted-average number of shares
outstanding during the reported period. For the years ended June 30, 2009 and 2008, the computation of pro forma net loss per basic and diluted share and the weighted-average shares outstanding are calculated based on the 23,974,211 shares
issued in connection with the spin-off on June 30, 2009. The calculation of diluted loss per share is the same as the basic loss per share since the inclusion of any potentially dilutive securities would be anti-dilutive for all years
presented. Total options outstanding of 1,772,293 could potentially be dilutive to future earnings per share.



| | (g) | Fair Value Disclosure
| | --- | ---------------------

At June 30, 2010 and 2009, the carrying value of the Companys other receivables, accounts payable and accrued
expenses approximates fair value.



| | (h) | Revenue Recognition
| | --- | -------------------

Revenue from non-refundable upfront license fees where the Company has continuing involvement is recognized ratably over
the development or agreement period or upon termination of a development or license agreement when the Company has no ongoing obligation.

Research revenue includes revenue from research services agreements, milestone payments, and technology licensing
agreements. In applying the principles of revenue recognition to research and technology license agreements the Company considers the terms and conditions of each agreement separately to arrive at a proportional performance methodology of
recognizing revenue. Such methodologies involve recognizing revenue on a straight-line basis over the term of the agreement, as underlying research costs are incurred, or on the basis of contractually defined output measures such as units delivered.
The Company makes adjustments, if necessary, to the estimates used in its calculations as work progresses and it gains experience. The principal costs under these agreements are for personnel expenses to conduct research and development but also
include costs for materials and other direct and indirect items necessary to complete the research under these agreements. Actual results may vary from estimates. Payments received on uncompleted long-term contracts may be greater than or less than
incurred costs and estimated earnings are recorded as other receivables or deferred revenues.



| | (i) | Research and Development Expenses
| | --- | ---------------------------------

Research and development expenses consist primarily of costs associated with the clinical trials of Myrexis product
candidates, development materials, compensation and related benefits for research and development personnel, costs for consultants, and various overhead costs. Research and development costs are expensed as incurred.



| | (j) | Selling, General and Administrative Expenses
| | --- | --------------------------------------------

Selling, general and administrative expenses as of June 30, 2010, include $1.5 million in reimbursed stipulated
expenses and a $2.9 million termination fee in connection with the proposed merger with Javelin Pharmaceuticals, Inc. that was terminated in April 2010. For the year ended June 30, 2010, the Company incurred expenses of $3.1 million in external
acquisition expenses which are offset by the fees described above.



| | (k) | Equipment and Leasehold Improvements
| | --- | ------------------------------------

Equipment and leasehold improvements are stated at cost. Depreciation and amortization are computed using the
straight-line method based on the lesser of estimated useful lives of the related assets or lease terms. Equipment items have depreciable lives of five years. Leasehold improvements are depreciated over the shorter of the estimated useful lives or
the associated lease terms, which range from three to fifteen years. For the years ended June 30, 2010, 2009, and 2008, the Company recorded depreciation expense of $1.2 million, $2.7 million, and $2.9 million, respectively.



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| | (l) | Impairment of Long-Lived Assets
| | --- | -------------------------------

Long-lived assets are reviewed for impairment whenever events or changes in circumstances indicate that the carrying
amount of an asset may not be recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of an asset to future net cash flows expected to be generated by the asset. If the carrying amount of an asset
exceeds its estimated future cash flows, an impairment charge is recognized in the amount by which the carrying amount of the asset exceeds the fair value of the asset. Assets to be disposed of are reported at the lower of the carrying amount or
fair value less costs to sell. For the year ended June 30, 2010, $0.2 million for impaired assets was recorded. No impairments of long-lived assets were recorded for the years ended June 30, 2009, and 2008.



| | (m) | Other Assets
| | --- | ------------

Other assets are comprised of purchased intellectual property, a purchased library of chemical compounds and a security
deposit for the sublease agreement entered into with MGI to provide for the lease of office and laboratory space in a new facility. Management reviews the valuation of these investments for possible impairment as changes in facts and circumstances
indicate that potential impairment should be assessed.

The library of chemical compounds and related purchased
intellectual property were fully amortized during the year ended June 30, 2010. Myrexis has also reassessed the useful lives of its other assets and has determined that the estimated useful lives are appropriate.

For the years ended June 30, 2010, 2009, and 2008, the Company recorded amortization expense of $95,000, $125,000,
and $30,000, respectively, related to these assets.

During 2008, the Company determined that the fair value of
its investment in the privately held pharmaceutical company was impaired and accordingly wrote-off its entire cost basis investment, which resulted in a $3.0 million expense recorded in other expense in the accompanying 2008 statements of
operations.



| | (n) | Income Taxes
| | --- | ------------

The Company recognizes income taxes under the asset and liability method. This approach requires the recognition of
deferred tax assets and liabilities for the expected future tax consequences of temporary differences between the carrying amounts and the tax bases of assets and liabilities.

The provision for income taxes, including the effective tax rate and analysis of potential tax exposure items, if any,
requires significant judgment and expertise in federal and state income tax laws, regulations and strategies, including the determination of deferred tax assets and liabilities and any estimated valuation allowances deemed necessary to recognize
deferred tax assets at an amount that is more likely than not to be realized. The Companys filings, including the positions taken therein, are subject to audit by various taxing authorities. While the Company believes it has provided
adequately for its income tax liabilities in the consolidated financial statements, adverse determinations by these taxing authorities could have a material adverse effect on the consolidated financial condition, results of operations or cash flows.

For periods prior to fiscal 2010, the Companys operations have been included in MGIs consolidated
U.S. federal and state income tax returns. The provision for income taxes has been determined as if the Company had filed separate income tax returns under its existing structure for the periods presented. Accordingly, the effective tax rate of the
Company in future years could vary from its historical effective tax rates depending on the Companys future legal structure and related tax elections. The historical net operating loss and research credit carryforwards generated by Myrexis
prior to the separation remained with MGI.



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| | (o) | Share-based compensation
| | --- | ------------------------

Certain Myrexis employees who were MGIs employees prior to the separation hold stock options and participated in the
MGI employee stock option and stock purchase plans. Share-based compensation expense in the accompanying financial statements for the years ended June 30, 2009 and 2008 is recognized based on MGIs share-based payment expense for such
Myrexis employees and certain allocated share-based compensation expense relating to general and administrative employees of MGI.

The Company recognizes compensation expense using a fair-value based method for costs related to stock options and other
equity-based compensation. The expense is measured based on the grant date fair value of the awards that are expected to vest, and the expense is recorded over the applicable requisite service period. In the absence of an observable market price for
a share-based award, the fair value is based upon a valuation methodology that takes into consideration various factors, including the exercise price of the award, the expected term of the award, the current price of the underlying shares, the
expected volatility of the underlying share price based on peer companies, the expected dividends on the underlying shares and the risk-free interest rate.



| | (p) | Marketable Investment Securities
| | --- | --------------------------------

The Company has classified its marketable investment securities as available-for-sale. These securities are carried at
estimated fair value with unrealized holding gains and losses, net of the related tax effect, included in accumulated other comprehensive income (loss) in stockholders equity until realized. Gains and losses on investment security transactions
are reported on the specific-identification method. Dividend and interest income are recognized when earned.

A
decline in the market value of any available-for-sale security below cost that is deemed other than temporary results in a charge to earnings and establishes a new cost basis for the security. Losses are charged against Other income
(expense) when a decline in fair value is determined to be other than temporary. The Company reviews several factors to determine whether a loss is other than temporary. These factors include but are not limited to: (i) the extent to
which the fair value is less than cost and the cause for the fair value decline, (ii) the financial condition and near term prospects of the issuer or declines in credit risk, (iii) the length of time a security is in an unrealized loss
position and (iv) the Company more likely than not, holding securities for a period of time sufficient to allow for any anticipated recovery in fair value. The Company recognized no impairments on available- for-sale securities for the year
ended June 30, 2010. Prior to June 30, 2009, all cash and investments were held and managed by MGI.



| | (q) | Segment and Related Information
| | --- | -------------------------------

ASC 280, Segment Reporting, redefines how operating segments are determined and requires disclosure of certain
financial and descriptive information about a companys operating segments. Myrexis business consists primarily of pharmaceutical development and related research activities. Accordingly, the Company operates in one reportable business
segment.

The Companys revenues were derived from research performed in the United States. Additionally,
all of the Companys long-lived assets are located in the United States.



| | (r) | Recent Accounting Pronouncements
| | --- | --------------------------------

In January 2010, the Financial Accounting Standards Board issued Accounting Standards Update (ASU) 2010-06,
Improving Disclosures about Fair Value Measurements. ASU 2010-06 requires additional disclosures about fair value measurements including transfers in and out of Levels 1 and 2 and a higher level of disaggregation for the different types of
financial instruments. For the reconciliation of Level 3 fair value measurements, information about purchases, sales, issuances and



F-11



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##### Table of Contents

settlements are presented separately. This standard is effective for interim and annual reporting periods beginning after December 15, 2009 with the exception of revised Level 3 disclosure
requirements which are effective for interim and annual reporting periods beginning after December 15, 2010. Comparative disclosures are not required in the year of adoption. The Company adopted the provisions of the standard on January 1,
2010, and the necessary disclosures are reflected in note 4.



|(2) | Spin-Off of Myrexis, Inc.
|--- | -------------------------

On June 30, 2009, MGI separated its molecular diagnostic business from its research and drug development businesses
through the spin-off of Myrexis. MGI contributed substantially all of the assets and certain liabilities from its research and drug development businesses and $188 million of cash and marketable securities to Myrexis. All outstanding shares of the
Company were then distributed to MGIs stockholders of record on June 17, 2009 as a pro-rata, tax-free dividend of one share of Myrexis common stock for every four shares of MGIs common stock.

On June 30, 2009, the Company entered into a Separation and Distribution Agreement with MGI that set forth the terms
and conditions of the separation of the Company from MGI. The Separation and Distribution Agreement sets forth a framework for the relationship between the Company and MGI following the separation regarding principal transactions necessary to
separate the companies, including: (i) the contribution of substantially all of the assets and certain liabilities of MGIS research and drug development businesses and cash and marketable securities of approximately $188 million to the
Company; and (ii) the distribution by MGI, as of 11:59 p.m. (EDT) on June 30, 2009, of all outstanding shares of Myrexis common stock to MGIs stockholders in the form of a pro rata dividend of one share of Myrexis common stock for
every four shares of MGIs common stock outstanding to stockholders of record on June 17, 2009. This agreement also sets forth other provisions that govern certain aspects of the Companys relationship with MGI after completion of the
separation and also provides for the allocation of assets, liabilities and obligations between the Company and MGI in connection with the separation.

In addition, on June 30, 2009 the Company entered into other definitive agreements in connection with the spin-off,
including (1) a Tax Sharing Agreement that generally governs the parties respective rights, responsibilities and obligations after the separation with respect to taxes (2) a Sublease Agreement that provides for the sublease from MGI
to the Company of certain office and laboratory space to be utilized by Myrexis in its operations and (3) an Employee Matters Agreement that allocates liabilities and responsibilities relating to employee compensation, benefit plans, programs
and other related matters in connection with the separation, including the treatment of outstanding incentive awards and certain retirement and welfare benefit obligations.



|(3) | Marketable Investment Securities
|--- | --------------------------------

The amortized cost, gross unrealized holding gains, gross unrealized holding losses, and fair value for available-for-sale
securities by major security type and class of security at June 30, 2010 and 2009 were as follows (in thousands):



|                          |  |               |         |                             |   |                              |  |   |                     |   |  |   |        
|------------------------- |  | ------------- | ------- | --------------------------- | - | ---------------------------- |  | - | ------------------- | - |  | - | -------
|                          |  | Amortizedcost |         | Grossunrealizedholdinggains |   | Grossunrealizedholdinglosses |  |   | Estimatedfair value
|June 30, 2010:            |  |               |         |                             |   |                              |  |   |                     |   |  |   |        
|Available-for-sale:       |  |               |         |                             |   |                              |  |   |                     |   |  |   |        
|Money Market Funds        |  | $             | 34,593  |                             | $ | 1                            |  | $ |                    |   |  | $ | 34,594 
|Corporate bonds and notes |  |               | 31,556  |                             |   |                             |  |   | (21                 | ) |  |   | 31,535 
|Federal agency issues     |  |               | 79,415  |                             |   | 45                           |  |   |                    |   |  |   | 79,460 
|                          |  |               |         |                             |   |                              |  |   |                     |   |  |   |        
|Total                     |  | $             | 145,564 |                             | $ | 46                           |  | $ | (21                 | ) |  | $ | 145,589
|                          |  |               |         |                             |   |                              |  |   |                     |   |  |   |        



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##### Table of Contents

|                          |  |               |         |                             |   |                              |  |                     |   |  |   |        
|------------------------- |  | ------------- | ------- | --------------------------- | - | ---------------------------- |  | ------------------- | - |  | - | -------
|                          |  | Amortizedcost |         | Grossunrealizedholdinggains |   | Grossunrealizedholdinglosses |  | Estimatedfair value
|June 30, 2009:            |  |               |         |                             |   |                              |  |                     |   |  |   |        
|Available-for-sale:       |  |               |         |                             |   |                              |  |                     |   |  |   |        
|Money Market Funds        |  | $             | 110,372 |                             | $ |                             |  | $                   |  |  | $ | 110,372
|Corporate bonds and notes |  |               | 28,740  |                             |   | 291                          |  |                     |  |  |   | 29,031 
|Federal agency issues     |  |               | 30,432  |                             |   | 170                          |  |                     |  |  |   | 30,602 
|                          |  |               |         |                             |   |                              |  |                     |   |  |   |        
|Total                     |  | $             | 169,544 |                             | $ | 461                          |  | $                   |  |  | $ | 170,005
|                          |  |               |         |                             |   |                              |  |                     |   |  |   |        

Cash and cash equivalents of $35.9
million at June 30, 2010 consist of cash and money market funds. As of June 30, 2010 the carrying value of cash equivalents approximates fair value. In addition, the Company holds $500,000 restricted cash in an 18-month certificate of
deposit as collateral for a corporate purchasing card program and $48,000 in a restricted cash account as collateral for office equipment. These amounts are included in long-term marketable securities on the balance sheet as of June 30, 2010.

Maturities of debt securities classified as available-for-sale are as follows at June 30, 2010 (in
thousands):



|                                       |  |               |         |                     |   |        
|-------------------------------------- |  | ------------- | ------- | ------------------- | - | -------
|                                       |  | Amortizedcost |         | Estimatedfair value
|Available-for-sale:                    |  |               |         |                     |   |        
|Due within one year                    |  | $             | 102,939 |                     | $ | 102,965
|Due after one year through three years |  |               | 8,032   |                     |   | 8,030  
|                                       |  |               |         |                     |   |        
|                                       |  | $             | 110,971 |                     | $ | 110,995
|                                       |  |               |         |                     |   |        



|(4) | Fair Value Measurements
|--- | -----------------------

The fair value of the Companys financial instruments reflects the amounts that the Company estimates to receive in
connection with the sale of an asset or paid in connection with the transfer of a liability in an orderly transaction between market participants at the measurement date (exit price). The fair value hierarchy prioritizes the use of inputs used in
valuation techniques into the following three levels:

Level 1quoted prices in active markets for identical assets and
liabilities.

Level 2observable inputs other than quoted prices in active markets for identical assets and liabilities;
quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. Some of the Companys marketable securities
primarily utilize broker quotes in a non-active market for valuation of these securities.

Level 3unobservable inputs.

The majority of the Companys financial instruments are valued using quoted prices in active markets or
based on other observable inputs. The following table sets forth the fair value of the Companys financial assets that the Company re-measured:



|                          |  |         |        |         |   |         |  |       |   |  |   |        
|------------------------- |  | ------- | ------ | ------- | - | ------- |  | ----- | - |  | - | -------
|(In thousands)            |  | Level 1 |        | Level 2 |   | Level 3 |  | Total
|June 30, 2010             |  |         |        |         |   |         |  |       |   |  |   |        
|Money market funds        |  | $       | 34,594 |         | $ |        |  | $     |  |  | $ | 34,594 
|Corporate bonds and notes |  |         |       |         |   | 31,535  |  |       |  |  |   | 31,535 
|Federal agency issues     |  |         |       |         |   | 79,460  |  |       |  |  |   | 79,460 
|                          |  |         |        |         |   |         |  |       |   |  |   |        
|Total                     |  | $       | 34,594 |         | $ | 110,995 |  | $     |  |  | $ | 145,589
|                          |  |         |        |         |   |         |  |       |   |  |   |        



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##### Table of Contents

|                          |  |         |         |         |   |         |  |       |   |  |   |        
|------------------------- |  | ------- | ------- | ------- | - | ------- |  | ----- | - |  | - | -------
|                          |  | Level 1 |         | Level 2 |   | Level 3 |  | Total
|June 30, 2009             |  |         |         |         |   |         |  |       |   |  |   |        
|Money market funds        |  | $       | 110,372 |         | $ |        |  | $     |  |  | $ | 110,372
|Corporate bonds and notes |  |         |        |         |   | 29,031  |  |       |  |  |   | 29,031 
|Federal agency issues     |  |         |        |         |   | 30,602  |  |       |  |  |   | 30,602 
|                          |  |         |         |         |   |         |  |       |   |  |   |        
|Total                     |  | $       | 110,372 |         | $ | 59,633  |  | $     |  |  | $ | 170,005
|                          |  |         |         |         |   |         |  |       |   |  |   |        

The Companys Level 1 assets
include cash and money market instruments. Level 2 assets consist of the Companys marketable investment securities that include federal agency issues, commercial paper, and corporate bonds. As of June 30, 2010, the Company has no
investments which were measured using unobservable (Level 3) inputs.



|(5) | Leases
|--- | ------

The Company entered into a sublease agreement with MGI effective July 1, 2009, as amended on November 11, 2009,
and February 19, 2010, that provides the sublease of certain office and laboratory space. The sublease for the Companys new facility took effect January 4, 2010 for a period of three years from the commencement date with the option
to extend for an additional four three-year periods. For the periods ended June 30, 2009 and 2008, an allocation of these lease costs is reflected in the financial statements using square footage of space occupied and other methodologies
described in note 11.

Rental expense for the year ended June 30, 2010 was $3.6 million. Rental expense
allocated to Myrexis was $2.7 million in 2009 and $2.3 million in 2008.

The table is reflective of the
new facility sublease. As of June 30, 2010 the future minimum lease payments under the sublease agreement are as follows:



|                    |  |   |      
|------------------- |  | - | -----
|Fiscal year ending: |  |   |      
|2011                |  | $ | 3,476
|2012                |  |   | 3,476
|2013                |  |   | 2,028
|                    |  |   |      
|                    |  | $ | 8,980
|                    |  |   |      



|(6) | Share-Based Compensation
|--- | ------------------------

Myrexis Share Based Compensation Plans

The Company adopted two equity incentive plans, the Myrexis, Inc. 2009 Employee, Director and Consultant Equity Incentive
Plan (the Equity Incentive Plan) and the Myrexis, Inc. 2009 Employee Stock Purchase Plan (the ESPP). At June 30, 2010, the Company was authorized to issue a total of 6.5 million shares under the plans. On
July 1, 2010, (a) the number of shares of common stock reserved for issuance under the Equity Incentive Plan 2006 was increased from 6,000,000 to 7,260,690 pursuant to an evergreen provision, which provides for an annual
increase equal to the lesser of 2,400,000 shares, 5% of the Companys then outstanding shares of common stock, or such other amount as the board of directors may determine, and (b) the number of shares of common stock reserved for issuance
under the ESPP was increased from 500,000 to 1,000,000 pursuant to an evergreen provision, which provides for an annual increase equal to the lesser of 500,000 shares, 2% of the Companys then outstanding shares of common stock, or
such other amount as the board of directors may determine.

The Equity Incentive Plan provides for the issuance
of common stock based awards, including restricted stock, restricted stock units, stock options, stock appreciation rights and other equity based awards the Company directors, officers, employees and consultants. In addition, pursuant to the
separation agreements the plan authorizes the issuance of stock options to certain current and former directors, officers, employees and consultants of MGI who were option holders of MGI at June 30, 2009.



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##### Table of Contents

The ESPP is intended to qualify as an employee stock purchase
plan under Section 423 of the Internal Revenue Code of 1986, as amended. Full-time employees of Myrexis who will own less than five percent of Myrexis, Incs outstanding shares of common stock will be eligible to contribute a
percentage of their base salary, subject to certain limitations, over the course of six-month offering periods for the purchase of shares of common stock. The purchase price for shares of common stock purchased under the ESPP will equal 85 percent
of the fair market value of a share of common stock at the beginning or end of the relevant six-month offering period, whichever is lower.

In connection with the separation from MGI and related transactions, each outstanding MGI stock option was converted into
an adjusted MGI common stock option, exercisable for the same number of shares of common stock as the original MGI option, and a new Myrexis common stock option, exercisable for one-fourth of the number of shares of common stock as the original MGI
option. All other terms of the converted options remained the same. However, the vesting and expiration of the converted options is based on the optionholders continuing employment with either MGI or Myrexis, as applicable, following the
separation. The adjusted exercise price of each converted option was determined in accordance with Section 409A and Section 422 of the Code, as follows:

The per share exercise price of each such MGI converted option is equal to the product of (i) the per share exercise
price of the original MGI option multiplied by (ii) a fraction, the numerator of which is the closing MGIs stock price on the day after the distribution, and the denominator of which is the ex-dividend closing stock price of MGI on the
day of the distribution plus one-quarter of the when-issued Myrexis stock price on the day of the distribution.

The per share exercise price of each such Myrexis converted option is equal to the product of (i) the per share
exercise price of the original MGI option multiplied by (ii) a fraction, the numerator of which is the closing Myrexis stock price on the day after the distribution, and the denominator of which is the ex-dividend closing stock price of MGI on
the day of the distribution plus one-quarter of the when-issued Myrexis stock price on the day of the distribution.

Accordingly, in connection with the separation and related transactions, the Company issued stock options to current and
former directors, officers, employees and consultants of MGI and Myrexis.

The exercise price of options
granted during the period ended June 30, 2010 was equivalent to the fair value of the stock on the date of grant. The number of shares, terms, and vesting periods are determined by the Companys board of directors or a committee thereof on
an option-by-option basis. Options generally vest ratably over service periods of four years and expire ten years from the date of grant. As of June 30, 2010, 1,413,784 shares were available for future grant under the Equity Incentive Plan.

The fair value of each option grant is estimated on the date of the grant using the Black-Scholes
option-pricing model with the following weighted-average assumptions used for grants for the fiscal years ended June 30:



|                          |  |           |  |           |  |          
|------------------------- |  | --------- |  | --------- |  | ---------
|                          |  | 2010      |  | 2009      |  | 2008     
|Risk-free interest rate   |  | 2.1%      |  | 2.4%      |  | 3.4%     
|Expected dividend yield   |  | 0%        |  | 0%        |  | 0%       
|Expected lives (in years) |  | 3.6 - 4.0 |  | 4.7 - 5.7 |  | 4.9 - 5.7
|Expected volatility       |  | 65.7%     |  | 42%       |  | 45%      

Expected option lives and volatilities are based on historical data of MGI and other factors. For the years ended
June 30, 2009 and 2008 the assumptions used were based on inputs related to grants issued prior to the spin-off. The differences in the assumptions are a result of Myrexis operating as an independent company.



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##### Table of Contents

A summary of option activity is as follows:



|                                                               |  |                 |   |      |                              |      |                 |           |                              |   |     
|-------------------------------------------------------------- |  | --------------- | - | ---- | ---------------------------- | ---- | --------------- | --------- | ---------------------------- | - | ----
|                                                               |  | 2010            |   | 2009
|                                                               |  | Number ofshares |   |      | Weightedaverageexerciseprice |      | Number ofshares |           | Weightedaverageexerciseprice
|Options outstanding at beginning of year                       |  | 3,592,372       |   |      | $                            | 2.42 |                 |          |                              | $ |    
|Options granted                                                |  | 1,491,318       |   |      |                              | 4.63 |                 | 3,592,372 |                              |   | 2.42
|Less:                                                          |  |                 |   |      |                              |      |                 |           |                              |   |     
|Options exercised                                              |  | (954,522        | ) |      |                              | 1.73 |                 |          |                              |   |    
|Options canceled or expired                                    |  | (729,664        | ) |      |                              | 3.53 |                 |          |                              |   |    
|                                                               |  |                 |   |      |                              |      |                 |           |                              |   |     
|Options outstanding at end of year                             |  | 3,399,504       |   |      |                              | 3.35 |                 | 3,592,372 |                              |   | 2.42
|                                                               |  |                 |   |      |                              |      |                 |           |                              |   |     
|Options exercisable at end of year                             |  | 1,332,330       |   |      |                              | 2.42 |                 | 1,781,044 |                              |   | 1.87
|                                                               |  |                 |   |      |                              |      |                 |           |                              |   |     
|Options vested and expected to vest                            |  | 3,123,280       |   |      |                              | 3.27 |                 | 3,294,764 |                              |   | 2.34
|                                                               |  |                 |   |      |                              |      |                 |           |                              |   |     
|Weighted average fair value of options granted during the year |  |                 |   |      |                              | 2.33 |                 |           |                              |   |    

The following table summarizes information about the stock options outstanding under our Equity Incentive Plan for both
Myrexis and MGI employees at June 30, 2010:



|                               |                                 |                     |                                                 |                     |                              |   |                                 |  |                              |  |      
|------------------------------ | ------------------------------- | ------------------- | ----------------------------------------------- | ------------------- | ---------------------------- | - | ------------------------------- |  | ---------------------------- |  | -----
|Range
ofexercise        prices |                                 | Options outstanding |                                                 | Options exercisable
|                               | NumberoutstandingatJune 30,2010 |                     | Weightedaverageremainingcontractuallife (years) |                     | Weightedaverageexerciseprice |   | NumberexercisableatJune 30,2010 |  | Weightedaverageexerciseprice
|$ 0.59 - 2.06                  |                                 | 1,027,544           |                                                 | 5.62                |                              | $ | 1.55                            |  | 741,409                      |  | $1.42
|2.07 - 3.95                    |                                 | 856,609             |                                                 | 6.35                |                              |   | 3.26                            |  | 427,140                      |  | 3.26 
|3.99 - 4.67                    |                                 | 1,003,061           |                                                 | 8.73                |                              |   | 4.51                            |  | 95,934                       |  | 4.63 
|4.73 - 5.12                    |                                 | 512,290             |                                                 | 8.40                |                              |   | 4.86                            |  | 67,847                       |  | 5.03 
|                               |                                 |                     |                                                 |                     |                              |   |                                 |  |                              |  |      
|                               |                                 | 3,399,504           |                                                 | 7.14                |                              |   | 3.35                            |  | 1,332,330                    |  | 2.42 
|                               |                                 |                     |                                                 |                     |                              |   |                                 |  |                              |  |      

The fair-value of each Myrexis stock option issued pursuant to the separation was
based on an allocation of the unamortized fair-value of the original MGI stock option from which it was derived. Myrexis recognizes share based compensation expense relating to both Myrexis and MGI options held by current directors, officers,
employees and consultants of Myrexis. Share based compensation expense relating to Myrexis options held by current and former directors, officers, employees and consultants of MGI will be recognized by MGI.

As of June 30, 2010, unrecognized compensation expense related to the unvested portion of MGIs stock options
granted to Myrexis employees and the unvested portion of Myrexis stock options granted was approximately $7.4 million and will be recognized over a weighted-average period of 2.55 years.

On July 1, 2009, the Company issued 284,740 restricted stock units under the Equity Incentive Plan at a fair value of
$4.03. As of June 30, 2010, the unrecognized compensation expense related to unvested restricted stock units was approximately $0.5 million and will be recognized over a weighted-average period of 1.96 years. The total intrinsic value of
options exercised during fiscal year ended June 30, 2010 was $3.4 million. The aggregate intrinsic value of options outstanding was approximately $2.7 million and the aggregate intrinsic value for options fully vested was approximately $2.0
million as of June 30, 2010.



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##### Table of Contents

Activity with respect to outstanding restricted stock units for the year
ended June 30, 2010 is as follows:



|                         |  |                 |   |  |                                    |     
|------------------------ |  | --------------- | - |  | ---------------------------------- | ----
|                         |  | Numberof shares |   |  | Weightedaveragegrantdate fairvalue
|Balance at June 30, 2009 |  |                |   |  | $                                  |    
|Granted                  |  | 284,740         |   |  |                                    | 4.03
|Cancelled                |  | (52,550         | ) |  |                                    | 4.03
|Vested                   |  | (87,724         | ) |  |                                    | 4.03
|                         |  |                 |   |  |                                    |     
|Balance at June 30, 2010 |  | 144,466         |   |  |                                    | 4.03
|                         |  |                 |   |  |                                    |     

Share-based compensation expense recognized for Myrexis employees included in the
statements of operations for the fiscal years ended June 30, 2010, 2009 and 2008 is as follows (in thousands):



|                                                |  |      |       |      |   |        |  |   |      
|----------------------------------------------- |  | ---- | ----- | ---- | - | ------ |  | - | -----
|                                                |  | 2010 |       | 2009 |   | 2008  
|Research and development                        |  | $    | 2,455 |      | $ | 8,991  |  | $ | 6,541
|Selling, general, and administrative            |  |      | 3,345 |      |   | 1,454  |  |   | 1,266
|                                                |  |      |       |      |   |        |  |   |      
|Total employee stock-based compensation expense |  | $    | 5,800 |      | $ | 10,445 |  | $ | 7,807
|                                                |  |      |       |      |   |        |  |   |      

For the year ended June 30, 2010,
Myrexis employees purchased 197,342 shares under the Myrexis ESPP. For the years ended June 30, 2009 and 2008, Myrexis employees participated in the employee stock purchase plan offered by MGI (the MGI ESPP), and
purchased 44,979 and 24,115 shares, respectively. Compensation expenses associated with Myrexis employees participating in the Myrexis ESPP (for fiscal 2010) and the MGI ESPP (for fiscal 2009 and 2008) were approximately $318,000, $340,000, and
$264,000, for the years ended June 30, 2010, 2009, and 2008, respectively. The fair value of shares issued under the Myrexis ESPP and the MGI ESPP, as applicable, was calculated using the Black-Scholes option-pricing model with the
following weighted-average assumptions for the fiscal years ended June 30:



|                          |  |      |  |      |  |     
|------------------------- |  | ---- |  | ---- |  | ----
|                          |  | 2010 |  | 2009 |  | 2008
|Risk-free interest rate   |  | 0.2% |  | 0.5% |  | 3.3%
|Expected dividend yield   |  | 0%   |  | 0%   |  | 0%  
|Expected lives (in years) |  | 0.5  |  | 0.5  |  | 0.5 
|Expected volatility       |  | 75%  |  | 54%  |  | 34% 



|(7) | Income Taxes
|--- | ------------

Income tax expense (benefit) consists of the following:



|                                   |  |                     |         |   |      |   |         |      |  |   |         |  
|---------------------------------- |  | ------------------- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | -
|(In thousands)                     |  | Year ended June 30, |        
|                                   |  | 2010                |         |   | 2009 |   |         | 2008 | 
|Current:                           |  |                     |         |   |      |   |         |      |  |   |         |  
|Federal                            |  | $                   |        |   |      | $ |        |      |  | $ |        |  
|State                              |  |                     |        |   |      |   |        |      |  |   |        |  
|                                   |  |                     |         |   |      |   |         |      |  |   |         |  
|Total Current                      |  |                     |        |   |      |   |        |      |  |   |        |  
|                                   |  |                     |         |   |      |   |         |      |  |   |         |  
|Deferred:                          |  |                     |         |   |      |   |         |      |  |   |         |  
|Federal                            |  |                     | (18,007 | ) |      |   | (22,650 | )    |  |   | (14,807 | )
|State                              |  |                     | (2,900  | ) |      |   | (4,620  | )    |  |   | (3,359  | )
|Change in valuation allowance      |  |                     | 20,907  |   |      |   | 27,270  |      |  |   | 18,166  |  
|                                   |  |                     |         |   |      |   |         |      |  |   |         |  
|Total Deferred                     |  |                     |        |   |      |   |        |      |  |   |        |  
|                                   |  |                     |         |   |      |   |         |      |  |   |         |  
|Total income tax expense (benefit) |  | $                   |        |   |      | $ |        |      |  | $ |        |  
|                                   |  |                     |         |   |      |   |         |      |  |   |         |  



F-17



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##### Table of Contents

The differences between income taxes at the statutory federal income tax
rate and income taxes reported in the consolidated statements of operations were as follows:



|                                                                          |  |                     |    |  |       |    |  |       |   
|------------------------------------------------------------------------- |  | ------------------- | -- |  | ----- | -- |  | ----- | --
|                                                                          |  | Year ended June 30, |   
|                                                                          |  | 2010                |    |  | 2009  |    |  | 2008  |   
|Federal income tax expense at the statutory rate                          |  | (34.0               | )% |  | (34.0 | )% |  | (34.0 | )%
|State income taxes, net of federal benefit                                |  | (3.3                | )  |  | (3.3  | )  |  | (3.3  | ) 
|Research and development credits, net of the federal tax on state credits |  | (1.7                | )  |  | (9.6  | )  |  | (15.6 | ) 
|Tax basis differences from spin off transaction                           |  | (5.7                | )  |  |      |    |  |      |   
|Change in valuation allowance                                             |  | 44.5                |    |  | 46.9  |    |  | 52.9  |   
|Other, net                                                                |  | 0.2                 |    |  |      |    |  |      |   
|                                                                          |  |                     |    |  |       |    |  |       |   
|                                                                          |  |                    | %  |  |      | %  |  |      | % 
|                                                                          |  |                     |    |  |       |    |  |       |   

The significant components of the Companys deferred tax assets and liabilities were
comprised of the following at June 30, 2010 and 2009:



|                                                         |  |                     |         |   |      |   |  
|-------------------------------------------------------- |  | ------------------- | ------- | - | ---- | - | -
|(In thousands)                                           |  | Year ended June 30,
|                                                         |  | 2010                |         |   | 2009
|Net operating loss carryforwards                         |  | $                   | 17,267  |   |      | $ | 
|Intangible assets                                        |  |                     | 1,401   |   |      |   | 
|Accrued vacation                                         |  |                     | 348     |   |      |   | 
|Stock compensation expense                               |  |                     | 1,607   |   |      |   | 
|Research and development credits                         |  |                     | 775     |   |      |   | 
|Property, plant and equipment                            |  |                     | (401    | ) |      |   | 
|Liability for unrecognized tax benefits                  |  |                     | (90     | ) |      |   | 
|                                                         |  |                     |         |   |      |   |  
|Total net deferred tax assets before valuation allowance |  |                     | 20,907  |   |      |   | 
|Less valuation allowance                                 |  |                     | (20,907 | ) |      |   | 
|                                                         |  |                     |         |   |      |   |  
|Net deferred tax assets                                  |  | $                   |        |   |      | $ | 
|                                                         |  |                     |         |   |      |   |  

For the years ended June 30, 2009
and 2008, respectively, the Companys operations were included in MGIs consolidated U.S. federal and state income tax returns. The income tax provision for those years has been determined as if the Company had filed separate income tax
returns under its existing structure for those periods. All net operating loss carryforwards and research tax credits generated prior to June 30, 2009 by the Company were retained by MGI upon the separation of the companies. Accordingly, the
Company had no material deferred tax assets and liabilities at June 30, 2009.

Due to losses incurred by
the Company, it has determined that it is more likely than not that the Companys deferred tax assets will not be realized. Accordingly, a valuation allowance has been established for the full amount of the Companys deferred tax assets.
The net change in the total valuation allowance was an increase of $20.9 million for the year ended June 30, 2010. Changes in valuation allowance for the years ended June 30, 2009 and 2008 were recorded at MGI and did not carry over to the
Company.

At June 30, 2010, the Company had total federal and state tax net operating loss carryforwards
of approximately $46.3 million. If not utilized, these operating loss carryforwards will expire in 2030. None of the net operating loss carryforwards are subject to the limitations imposed by Section 382 of the Internal Revenue Code. The
Company had approximately $0.6 million of federal research tax credits, which can be carried forward to reduce federal income taxes. Additionally, the Company had approximately $0.2 million of Utah research tax credits, which can be carried forward
to reduce Utah income taxes. If not utilized, the federal and Utah research tax credit carryforwards expire in 2030 and 2024, respectively.

Approximately $3.6 million of net operating loss tax benefits are excess tax benefits as defined by ASC
guidance. As such, they are not included in deferred tax assets. They will be recognized as additional paid-in-capital only upon realization of the tax benefit.



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##### Table of Contents

The Company has adopted the provisions of ASC Topic 740 Subtopic 10
Section 05, which addresses the accounting for uncertainty in tax positions. ASC guidance requires that the impact of a tax position be recognized in the financial statements if that position is more likely than not of being sustained on audit,
based on the technical merits of the position. For the year ended June 30, 2010, the Company recorded unrecognized tax benefits of approximately $90,000. The liability is directly associated with tax credit carryforwards which have not been
utilized at June 30, 2010 and has been netted against the Companys deferred tax assets.

A
reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows:



|                                           |  |                     |    |      |   |      |  |   |  
|------------------------------------------ |  | ------------------- | -- | ---- | - | ---- |  | - | -
|                                           |  | Year ended June 30,
|(In thousands)                             |  | 2010                |    | 2009 |   | 2008
|Gross increasescurrent year tax positions |  | $                   | 90 |      | $ |     |  | $ | 
|                                           |  |                     |    |      |   |      |  |   |  
|Unrecognized tax benefits at end of year   |  | $                   | 90 |      | $ |     |  | $ | 
|                                           |  |                     |    |      |   |      |  |   |  

Approximately $90,000 of the total
unrecognized tax benefits as of June 30, 2010, if recognized, would affect the effective tax rate. The Company does not anticipate that unrecognized tax benefits will significantly increase or decrease within 12 months of the reporting date.
Interest and penalties related to uncertain tax positions are included as a component of income tax expense.

The Company files U.S. and various state income tax returns. The 2009 tax year (the Companys only tax year as a
separate entity) will remain subject to examination for three years after its filing. The Companys federal tax return and state tax returns are not currently under examination. Annual tax provisions include amounts considered necessary to pay
assessments that may result from examination of the Companys tax returns. However, the amount ultimately paid upon resolution of issues may differ materially from the amount accrued.



|(8) | Stockholders Equity
|--- | --------------------



| | Comprehensive | income
| | ------------- | ------

The components of the Companys comprehensive income are as follows:



|                                                          |  |          |         |   |      |   |         |  
|--------------------------------------------------------- |  | -------- | ------- | - | ---- | - | ------- | -
|                                                          |  | June 30, |        
|(In thousands)                                            |  | 2010     |         |   | 2009 |  
|Net Loss                                                  |  | $        | (46,951 | ) |      | $ | (58,136 | )
|Other comprehensive loss:                                 |  |          |         |   |      |   |         |  
|Change in unrealized gain (loss) on marketable securities |  |          | (436    | ) |      |   | 461     |  
|                                                          |  |          |         |   |      |   |         |  
|Total comprehensive loss                                  |  | $        | (47,387 | ) |      | $ | (57,675 | )
|                                                          |  |          |         |   |      |   |         |  



|(9) | Employee Deferred Savings Plan
|--- | ------------------------------

During fiscal years 2010, 2009 and 2008, the Myrexis employees participated in a deferred savings plan which qualifies
under Section 401(k) of the Internal Revenue Code. Substantially all of the Myrexis employees were covered by the plan. Myrexis made matching contributions of 50% of each employees contribution with the employers contribution not to
exceed 4% of the employees compensation. Myrexis contributions to the plan were $552,000, $594,000, and $618,000 for the years ended June 30, 2010, 2009, and 2008, respectively. Prior to the spin-off on June 30, 2009, matching
contributions were made by MGI under the MGI deferred savings plan.



F-19



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##### Table of Contents

|(10) | Collaborative Agreements
|---- | ------------------------

During the year ended June 30, 2010, Myrexis did not enter into any new collaborative agreements.

In May 2008, Myrexis entered into a collaboration agreement with H. Lundbeck A/S (Lundbeck) granting certain
marketing rights for Myrexiss therapeutic candidate Flurizan. Under the terms of the agreement Lundbeck paid Myrexis a $100 million non-refundable fee, and agreed to pay future royalties, sales-based milestones, and share certain development
costs. As cash was managed at the corporate level by MGI, the license fee was received and recorded by MGI, resulting in a decrease in MGIs net investment in Myrexis at June 30, 2008.

On June 30, 2008, based on results from the U.S. Phase III clinical trial, Myrexis announced its intention to
discontinue all Flurizan development activities. Both Myrexis and Lundbeck concluded that Flurizan had no future economic value and that Myrexis had no continuing substantive obligations to Lundbeck. Based on this conclusion, Myrexis recognized the
$100 million as pharmaceutical revenue in the accompanying statements of operations for the year ended June 30, 2008.

Due to the termination of Flurizan development, Myrexis also canceled certain agreements relating to clinical trials, drug
manufacturing, and other activities. Myrexis estimated and recorded approximately $3.0 million of research and development expense for the cancellation of these development agreements in the year ended June 30, 2008.

Upon receipt of the up-front payment from Lundbeck in June 2008, Myrexis also recorded a one-time sublicense expense of
$20 million which represented the potential amount payable to a third party for the license of the Flurizan compound. The amount was recorded as research and development expense and a related accrued liability at June 30, 2008. In
March 2009, this liability was settled for $11 million. Accordingly, the Company recognized a credit to its research and development expense of $9 million during the fiscal year ended June 30, 2009.

In June 2006, the Company entered into a research collaboration to apply its high-speed genomic sequencing capability and
bioinformatics expertise to deliver molecular genetic information to the collaborator. Revenue related to this collaboration is recognized when completed information is delivered to the collaborator. Under this agreement the Company recognized
research revenue of $0, $3.1 million and $0 for the fiscal years ended June 30, 2010, 2009 and 2008, respectively.

In June 2004, the Company entered into a five-year, research agreement to utilize its expertise to characterize
pathogen-host protein interactions. Revenue related to this collaboration was recognized on a cost-to-cost basis. Under this agreement the Company recognized research revenue of $0, $2.2 million and $3.3 million for the fiscal years ended
June 30, 2010, 2009, and 2008, respectively.



|(11) | Related Party Transactions
|---- | --------------------------

For the periods ended June 30, 2009 and 2008, the Companys operations were fully integrated with MGI, including
executive services, finance, treasury, corporate income tax, human resources, legal services and investor relations. The accompanying financial statements reflect the application of certain estimates and allocations of operating expenses. Management
believes the methods used to allocate these operating expenses are reasonable. The allocation methods include relative time devoted by executive management on Myrexis business and related benefit received by Myrexis for other services such as costs
associated with being a public company and other services. Allocation of expenses for these services of $6,105,000 and $7,536,000 for the years ended June 30, 2009 and 2008, respectively, are reflected in total operating expenses in the
statements of operations. Operating expenses for the year ended June 30, 2010, reflect the costs associated with being an independent publicly traded company.



F-20



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##### Table of Contents

|(12) | Asset Acquisitions
|---- | ------------------

On January 20, 2009, Myrexis, Inc. purchased certain in-process research and development assets related to the HIV
candidate MPC-4326 from Panacos Pharmaceuticals, Inc. The assets were determined to be in-process research and development assets and were charged to expense on the acquisition date. The aggregate purchase price was $7 million, which represented
cash consideration. Myrexis has assumed control of all clinical and commercial development of MPC-4326.

On
April 10, 2008, Myrexis acquired certain assets of NaturNorth Technologies, LLC. Myrexis purchased the NaturNorth assets primarily to acquire key technology. Myrexis has accounted for the acquisition as a purchase of assets.

The aggregate purchase price was approximately $1.35 million, which represented cash consideration. The following table
summarizes the allocation of the aggregate purchase price and the estimated useful life for the acquired intangible asset (in thousands):



|                                                     |  |   |      
|---------------------------------------------------- |  | - | -----
|R&D Supplies                                         |  | $ | 452  
|Acquired Intangible:                                 |  |   |      
|Existing Technology (two year estimated useful life) |  |   | 250  
|Plant, property and equipment                        |  |   | 648  
|                                                     |  |   |      
|Net Assets Acquired                                  |  | $ | 1,350
|                                                     |  |   |      

The NatureNorth tangible assets
acquired by Myrexis were valued at their respective current fair value. The R&D supplies, consisting primarily of raw material inventory, was immediately expensed to research and development as it represented material to be used for in-process
research and development projects and has no alternative uses. The acquired fixed assets had an estimated useful life of five years and the acquired intangible asset had an estimated useful life of two years. As of June 30, 2010, the acquired
intangible asset was fully amortized.



|(13) | Stockholder Rights Plan
|---- | -----------------------

In June 2009, the Company declared a dividend of one preferred stock purchase right (a Right) for each
outstanding share of the Companys common stock to be paid on June 30, 2009 (the Record Date) to holders of record of the Common Stock immediately following the distribution of shares of Common Stock to the stockholders of MGI.
Each Right entitles the registered holder to purchase from the Company one one-thousandth of a share of Series A Junior Participating Preferred Stock. The rights have certain anti-takeover effects since, under certain circumstances, the rights allow
the Companys stockholders (other than an acquiror) to acquire common stock in the Company or equivalent consideration at a substantial discount if a person or persons acting as a group, directly or indirectly, obtain control of 15% of more of
the Companys Common Stock. The Rights are not currently exercisable and will expire at the close of business on June 30, 2019, unless earlier redeemed or exchanged by the Company.



|(14) | Commitments and Contingencies
|---- | -----------------------------

MGI had entered into a license agreement for exclusive rights to utilize certain intellectual property rights related to
the drug candidate Azixa. Pursuant to the Separation Agreement, Myrexis has assumed all rights and obligations under this the license agreement. Under this agreement Myrexis may pay milestone payments totaling up to $23 million. Payment of
milestones is based on the occurrence of potential future events, including the initiation of certain human clinical trials, filing of a New Drug Application with the Food and Drug Administration, receipt of regulatory approval, and specific revenue
targets.

Various legal claims have been filed against Myrexis that relate to the ordinary course of business
and are currently pending resolution. In the opinion of management and upon consultation with legal counsel, the ultimate resolution of these matters is not expected to have a material adverse effect on the financial position or future results of
operations of Myrexis.



F-21



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##### Table of Contents

EXHIBIT INDEX



|                                                                              |  |                                                                                                                                                                                                                                     |  |                      |  |                                                     |  |            |  |                             
|----------------------------------------------------------------------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | -------------------- |  | --------------------------------------------------- |  | ---------- |  | ----------------------------
|Exhibit
Number                                                                |  | Exhibit Description                                                                                                                                                                                                                 |  | Filedwith thisReport |  | Incorporated byReference hereinfrom Form orSchedule |  | FilingDate |  | SEC File /RegistrationNumber
|2.1                                                                           |  | Separation and Distribution Agreement, dated June 30, 2009, by and between the Registrant and Myriad Genetics, Inc.                                                                                                                 |  |                      |  | 8-K(Exhibit 2.1)                                    |  | 7/7/09     |  | 001-34275                   
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|3.1                                                                           |  | Amended and Restated Certificate of Incorporation of the Registrant                                                                                                                                                                 |  | X                    |  |                                                     |  |            |  |                             
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|3.1.1                                                                         |  | Certificate of Designation, Preferences and Rights of Series A Junior Participating Preferred Stock                                                                                                                                 |  | X                    |  |                                                     |  |            |  |                             
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|3.1.2                                                                         |  | Certificate of Amendment to Restated Certificate of Incorporation of the Registrant                                                                                                                                                 |  | X                    |  |                                                     |  |            |  |                             
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|3.2                                                                           |  | Amended and Restated Bylaws of the Registrant                                                                                                                                                                                       |  | X                    |  |                                                     |  |            |  |                             
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|4.1                                                                           |  | Form of Common Stock Certificate of the Registrant                                                                                                                                                                                  |  |                      |  | 10/A(Exhibit 4.1)                                   |  | 6/8/09     |  | 001-34275                   
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|4.2                                                                           |  | Shareholder Rights Agreement between the Registrant and American Stock Transfer & Trust Company, LLC, dated June 30, 2009, which includes as Exhibit B the form of Right
Certificate                                                |  |                      |  | 8-A(Exhibit 4.1)                                    |  | 6/30/09    |  | 001-34275                   
|                                                                              |  |                                                                                                                                                                                                                                    
|Agreements with Myriad Genetics, Inc.                                         |  |                                                                                                                                                                                                                                     |  |                     
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|10.1                                                                          |  | Tax Sharing Agreement, dated June 30, 2009, by and between the Registrant and Myriad Genetics, Inc.                                                                                                                                 |  |                      |  | 8-K(Exhibit 10.1)                                   |  | 7/7/09     |  | 001-34275                   
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|10.2                                                                          |  | Sublease Agreement, effective July 1, 2009, by and between the Registrant and Myriad Genetics, Inc.                                                                                                                                 |  |                      |  | 8-K(Exhibit 10.2)                                   |  | 7/7/09     |  | 001-34275                   
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|10.2.1                                                                        |  | Amendment No. 1, effective November 11, 2009, to Sublease Agreement, effective July 1, 2009, by and between the Registrant and Myriad Genetics, Inc.                                                                                |  |                      |  | 10-Q(Exhibit 10.1)                                  |  | 11/12/09   |  | 001-34275                   
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|10.2.2                                                                        |  | Amendment No. 2, dated February 19, 2010, to Sublease Agreement, effective July 1, 2009, by and between the Registrant and Myriad Genetics, Inc.                                                                                    |  |                      |  | 10-Q(Exhibit 10.2)                                  |  | 5/17/10    |  | 001-34275                   
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|10.3                                                                          |  | Employee Matters Agreement, dated June 30, 2009, by and between the Registrant and Myriad Genetics, Inc.                                                                                                                            |  |                      |  | 8-K(Exhibit 10.3)                                   |  | 7/7/09     |  | 001-34275                   
|                                                                              |  |                                                                                                                                                                                                                                    
|Agreements with Respect to Collaborations, Licenses, Research and Development |  |                                                                                                                                                                                                                                     |  |                     
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|10.4                                                                         |  | License and Collaboration Agreement, dated November 19, 2003, by and among Myriad Genetics, Inc., Maxim Pharmaceuticals, Inc., and Cytovia, Inc. (now known as Epicept Corporation),
as assigned to the Registrant on June 30, 2009 |  |                      |  | 10/A(Exhibit 10.4)                                  |  | 5/11/09    |  | 001-34275                   
|                                                                              |  |                                                                                                                                                                                                                                     |  |                      | 
|10.5                                                                         |  | License Agreement, effective as of January 20, 2009, between the University of North Carolina at Chapel Hill and the Registrant                                                                                                     |  |                      |  | 10(Exhibit 10.5)                                    |  | 4/1/09     |  | 001-34275                   



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##### Table of Contents

|                                                 |  |                                                                                                                                                                                                                     |  |                      |  |                                                     |  |            |  |                             
|------------------------------------------------ |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | -------------------- |  | --------------------------------------------------- |  | ---------- |  | ----------------------------
|Exhibit
Number                                   |  | Exhibit Description                                                                                                                                                                                                 |  | Filedwith thisReport |  | Incorporated byReference hereinfrom Form orSchedule |  | FilingDate |  | SEC File /RegistrationNumber
|                                                 |  |                                                                                                                                                                                                                    
|Equity Compensation Plans                        |  |                                                                                                                                                                                                                     |  |                     
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.6                                            |  | 2009 Employee, Director and Consultant Stock Plan (the 2009 Plan)                                                                                                                                                 |  |                      |  | 10/A(Exhibit 10.6)                                  |  | 6/8/09     |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.6.1                                          |  | Form of Stock Option Agreement under the 2009 Plan                                                                                                                                                                  |  |                      |  | 10/A(Exhibit 10.6.1)                                |  | 6/8/09     |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.6.2                                          |  | Form of Restricted Stock Unit Agreement under the 2009 Plan                                                                                                                                                         |  |                      |  | 10/A(Exhibit 10.6.2)                                |  | 6/8/09     |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.6.3                                          |  | Form of Incentive Stock Option Agreement under the 2009 Plan for Rollover Options issued under the Myriad Genetics, Inc. 2003 Employee, Director and Consultant Stock Option Plan, as
amended (the MGI 2003 Plan) |  |                      |  | 10/A(Exhibit 10.6.3)                                |  | 6/8/09     |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.6.4                                          |  | Form of Non-Qualified Stock Option Agreement under the 2009 Plan for Rollover Options issued under the MGI 2003 Plan                                                                                                |  |                      |  | 10/A(Exhibit 10.6.4)                                |  | 6/8/09     |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.6.5                                          |  | Form of Incentive Stock Option Agreement under the 2009 Plan for Rollover Options issued under the Myriad Genetics, Inc. 2002 Employee, Director and Consultant Stock Option Plan, as
amended (the MGI 2002 Plan) |  |                      |  | 10/A(Exhibit 10.6.5)                                |  | 6/8/09     |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.6.6                                          |  | Form of Non-Qualified Stock Option Agreement under the 2009 Plan for Rollover Options issued under the MGI 2002 Plan                                                                                                |  |                      |  | 10/A(Exhibit 10.6.6)                                |  | 6/8/09     |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.7                                            |  | 2009 Employee Stock Purchase Plan                                                                                                                                                                                   |  |                      |  | 10/A(Exhibit 10.7)                                  |  | 6/8/09     |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                    
|Agreements with Executive Officers and Directors |  |                                                                                                                                                                                                                     |  |                     
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|10.8                                             |  | Form of Indemnification Agreement between the Registrant and its directors and officers                                                                                                                             |  |                      |  | 10/A(Exhibit 10.8)                                  |  | 5/29/09    |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.9                                            |  | Non-Employee Director Compensation Policy                                                                                                                                                                           |  |                      |  | 10/A(Exhibit 10.9)                                  |  | 6/8/09     |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.10                                           |  | Form of Employment Agreement between the Registrant and its officers                                                                                                                                                |  |                      |  | 10-K(Exhibit 10.10)                                 |  | 9/28/09    |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.11                                           |  | Offer Letter between the Registrant and
Robert J. Lollini, dated January 30, 2009                                                                                                                                   |  |                      |  | 10-K(Exhibit 10.11)                                 |  | 9/28/09    |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.12                                           |  | Management PerformanceIncentive Bonus Program Fiscal Year 2010                                                                                                                                                     |  |                      |  | 10-K(Exhibit 10.12)                                 |  | 9/28/09    |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.13                                           |  | Executive Severance and Change in Control Agreement by and between the Registrant and Adrian N. Hobden, dated February 1, 2010                                                                                      |  |                      |  | 8-K(Exhibit 10.1)                                   |  | 2/4/10     |  | 001-34275                   
|                                                 |  |                                                                                                                                                                                                                     |  |                      | 
|*10.14                                           |  | Form of Executive Severance and Change in Control Agreement entered into between the Registrant and the Executive Officers of the Registrant listed on Schedule I attached thereto,
on February 1, 2010             |  |                      |  | 8-K(Exhibit 10.2)                                   |  | 2/4/10     |  | 001-34275                   



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##### Table of Contents

|               |  |                                                                                                                                                                     |  |                      |  |                                                     |  |            |  |                             
|-------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | -------------------- |  | --------------------------------------------------- |  | ---------- |  | ----------------------------
|Exhibit
Number |  | Exhibit Description                                                                                                                                                 |  | Filedwith thisReport |  | Incorporated byReference hereinfrom Form orSchedule |  | FilingDate |  | SEC File /RegistrationNumber
|*10.15         |  | First Amendment, dated June 3, 2010, to Executive Severance and Change in Control Agreement by and between the Registrant and Barbara Berry, dated February 1, 2010 |  |                      |  | 8-K(Exhibit 10.1)                                   |  | 6/9/10     |  | 001-34275                   
|               |  |                                                                                                                                                                     |  |                      | 
|*10.16         |  | Consulting Agreement by and between the Registrant and Barbara Berry, dated June 8, 2010                                                                            |  | X                    |  |                                                     |  |            |  |                             
|               |  |                                                                                                                                                                     |  |                      | 
|*10.17         |  | Consulting Agreement by and between the Registrant and Edward Swabb, dated June 18, 2010                                                                            |  | X                    |  |                                                     |  |            |  |                             
|               |  |                                                                                                                                                                     |  |                      | 
|*10.18         |  | Notice of Termination and Release by and between the Registrant and Barbara Berry, dated June 3, 2010                                                               |  | X                    |  |                                                     |  |            |  |                             
|               |  |                                                                                                                                                                     |  |                      | 
|*10.19         |  | Notice of Termination and Release by and between the Registrant and Edward Swabb, dated June 18, 2010                                                               |  | X                    |  |                                                     |  |            |  |                             
|               |  |                                                                                                                                                                     |  |                      | 
|21.1           |  | List of Subsidiaries of the Registrant                                                                                                                              |  |                      |  | S-4(Exhibit 21.1)                                   |  | 2/12/10    |  | 333-164890                  
|               |  |                                                                                                                                                                     |  |                      | 
|23.1           |  | Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm                                                                                         |  | X                    |  |                                                     |  |            |  |                             
|               |  |                                                                                                                                                                     |  |                      | 
|31.1           |  | Certification of the Chief Executive Officer under Section 302 of the Sarbanes-Oxley Act of 2002                                                                    |  | X                    |  |                                                     |  |            |  |                             
|               |  |                                                                                                                                                                     |  |                      | 
|31.2           |  | Certification of the Chief Financial Officer under Section 302 of the Sarbanes-Oxley Act of 2002                                                                    |  | X                    |  |                                                     |  |            |  |                             
|               |  |                                                                                                                                                                     |  |                      | 
|32.1           |  | Certification of the Chief Executive Officer and the Chief Financial Officer under Section 906 of the Sarbanes- Oxley Act of 2002                                   |  | X                    |  |                                                     |  |            |  |                             



|* | Management contract, compensatory plan or arrangement.
|- | ------------------------------------------------------



| | Confidential portions of these documents have been filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment.
|- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------