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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 20-F

(Mark One)



| ̈ | REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------------

OR



|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended June 30, 2007

OR



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from  to

OR



| ̈ | SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | -------------------------------------------------------------------------------------------

Date of event requiring this shell company report

Commission file number 000-51505

Pharmaxis Ltd

(Exact
name of Registrant as specified in its charter)



---

(Translation of Registrants name into English)

Australia

(Jurisdiction of incorporation or organization)

Unit 2, 10 Rodborough Road, Frenchs Forest, NSW 2086, Australia

(Address of principal executive offices)

Securities registered or to be registered pursuant to
Section 12(b) of the Act.



|                                                                                                     |  |                                          
|---------------------------------------------------------------------------------------------------- |  | -----------------------------------------
|Title of each class                                                                                  |  | Name of each exchange on which registered
|Ordinary Shares in the form of American Depositary Shares, evidenced by American Depositary Receipts |  | Nasdaq Global Market                     



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Securities registered or to be registered pursuant to Section 12(g) of the Act.

None

Securities for which there is a
reporting obligation pursuant to Section 15(d) of the Act.

None

As of June 30, 2007 the number of outstanding shares of each of the issuers classes of capital or common stock was as
follows: 177,949,217 fully paid Ordinary Shares.

Indicate by check mark if the registrant is a well-known seasoned issuer as defined
in Rule 405 of the Securities Act

 ̈Yes    x   No

Indicate by
check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

 ̈Yes    x   No

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities
Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

x  Yes ̈No

Indicate by check mark whether the registrant is a
large accelerated filer, an accelerated filer or a non-accelerated filer

 ̈Large Accelerated filer            x  Accelerated
filer ̈Non-accelerated filer

Indicate by check mark which financial statement item the registrant has elected to follow.

 ̈Item 17    x   Item 18

If this is an annual report, indicate by check mark whether the registrant is a
shell company (as defined in Rule 12b-2 of the Exchange Act).

 ̈Yes    x   No

(APPLICABLE ONLY TO ISSUERS
INVOLVED IN BANKRUPTCY PROCEEDINGS DURING THE PAST FIVE YEARS)

Indicate by check mark whether the registrant has filed all documents and
reports required to be filed by Sections 12, 13 or 15(d) of the Securities Exchange Act of 1934 subsequent to the distribution of the securities under a plan confirmed by a court.

 ̈Yes ̈No



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TABLE OF CONTENTS



|                           |  |                                                                              |  |    
|-------------------------- |  | ---------------------------------------------------------------------------- |  | ---
|FORWARD LOOKING STATEMENTS |  | 1                                                                           
|ITEM 1.                    |  | IDENTITY OF DIRECTORS, SENIOR MANAGEMENT AND ADVISORS                        |  | 2  
|ITEM 2.                    |  | OFFER STATISTICS AND EXPECTED TIMETABLE                                      |  | 2  
|ITEM 3.                    |  | KEY INFORMATION                                                              |  | 2  
|ITEM 4.                    |  | INFORMATION ON THE COMPANY                                                   |  | 27 
|ITEM 5.                    |  | OPERATING AND FINANCIAL REVIEW AND PROSPECTS                                 |  | 46 
|ITEM 6.                    |  | DIRECTORS, SENIOR MANAGEMENT AND EMPLOYEES                                   |  | 57 
|ITEM 7.                    |  | MAJOR SHAREHOLDERS AND RELATED PARTY TRANSACTIONS                            |  | 77 
|ITEM 8.                    |  | FINANCIAL INFORMATION                                                        |  | 81 
|ITEM 9.                    |  | THE OFFER AND LISTING                                                        |  | 81 
|ITEM 10.                   |  | ADDITIONAL INFORMATION                                                       |  | 83 
|ITEM 11.                   |  | QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK                   |  | 99 
|ITEM 12.                   |  | DESCRIPTION OF SECURITIES OTHER THAN EQUITY SECURITIES                       |  | 99 
|ITEM 13.                   |  | DEFAULTS, DIVIDEND ARREARAGES AND DELINQUENCIES                              |  | 100
|ITEM 14.                   |  | MATERIAL MODIFICATIONS TO THE RIGHTS OF SECURITY HOLDERS AND USE OF PROCEEDS |  | 100
|ITEM 15.                   |  | CONTROLS AND PROCEDURES                                                      |  | 100
|ITEM 16A.                  |  | AUDIT COMMITTEE FINANCIAL EXPERT                                             |  | 101
|ITEM 16B.                  |  | CODE OF ETHICS                                                               |  | 101
|ITEM 16C.                  |  | PRINCIPAL ACCOUNTANT FEES AND SERVICES                                       |  | 101
|ITEM 16D.                  |  | EXEMPTIONS FROM THE LISTING STANDARDS FOR AUDIT COMMITTEES                   |  | 101
|ITEM16E.                   |  | PURCHASES OF EQUITY SECURITIES BY THE ISSUER AND AFFILIATED PURCHASERS       |  | 102
|ITEM 17.                   |  | FINANCIAL STATEMENTS                                                         |  | 103
|ITEM 18.                   |  | FINANCIAL STATEMENTS                                                         |  | 103
|ITEM 19.                   |  | EXHIBITS                                                                     |  | 103

In this annual report on Form 20-F, the terms we, our,
us, Pharmaxis Ltd, Pharmaxis and the Company refer to Pharmaxis Ltd. Unless otherwise noted herein, all references to dollars and dollar amounts are references to Australian
dollars. Our Australian company number is ACN 082 811 630 and our Australian business number is ABN 75 082 811 630.



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FORWARD LOOKING STATEMENTS

Some of the statements made under Item 3. Key Information 
D. Risk Factors Item 4. Information on the Company Item 5. Operating and Financial Review and Prospects and elsewhere in this report on Form 20-F constitute forward-looking statements. In some cases,
you can identify forward-looking statements by terminology such as may, will, should, expects, plans, anticipates, believes, estimates,
predicts, potential, or continue, or the negative of these terms or other comparable terminology. These statements are only current predictions and are subject to known and unknown risks, uncertainties and
other factors that may cause our or our industrys actual results, levels of activity, performance or achievements to be materially different from those anticipated by the forward-looking statements. These factors include, among other
things, those listed under Item 3. Key Information  D. Risk Factors and elsewhere in this report on Form 20-F.

Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance or achievements. Except as required by law, we are under no duty
to update or revise any of our forward-looking statements, whether as a result of new information, future events or otherwise, after the date of this report on Form 20-F.



1



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PART I



|ITEM 1. | IDENTITY OF DIRECTORS, SENIOR MANAGEMENT AND ADVISORS
|------- | -----------------------------------------------------



|A. | Directors and Senior Management
|-- | -------------------------------

Not applicable.



|B. | Advisors
|-- | --------

Not applicable.



|C. | Auditors
|-- | --------

Not applicable.



|ITEM 2. | OFFER STATISTICS AND EXPECTED TIMETABLE
|------- | ---------------------------------------

Not applicable.



|ITEM 3. | KEY INFORMATION
|------- | ---------------



|A. | Selected Financial Data
|-- | -----------------------

The following table
presents our selected financial data for the dates and periods indicated. This data should be read together with Item 5 - Operating and Financial Review and Prospects. The statement of operations data for the years ended
June 30, 2005, 2006 and 2007, and for the period from inception (May 29, 1998) to June 30, 2007, and the balance sheet data as of June 30, 2006 and 2007, were derived from our audited financial statements and related notes thereto
included elsewhere in this annual report, were prepared in accordance with U.S. GAAP and are presented in Australian dollars (except as otherwise noted). The statement of operations data for the years ended June 30, 2003 and 2004, and the
balance sheet data as of June 30, 2003, 2004 and 2005, are derived from our audited financial statements and related notes thereto which are not included in this report, were prepared in accordance with U.S. GAAP and are presented in Australian
dollars (except as otherwise noted). Our fiscal year ends on June 30. We designate our fiscal year by the year in which that fiscal year ends; e.g., fiscal year 2007 refers to our fiscal year ended June 30, 2007.



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|                                                                                                       |  |                                                    |        |   |                                                    |   |        |                            |  |   |         |   |  |      |         |   |    |   |         |       |  |   |         |   |  |   |         |  
|------------------------------------------------------------------------------------------------------ |  | -------------------------------------------------- | ------ | - | -------------------------------------------------- | - | ------ | -------------------------- |  | - | ------- | - |  | ---- | ------- | - | -- | - | ------- | ----- |  | - | ------- | - |  | - | ------- | -
|                                                                                                       |  | Year ended June 30,                                |        |   | Period frominception(May 29, 1998)to June 30, 2007 |   |        | Year endedJune 30, 2007(2) | 
|                                                                                                       |  | 2003                                               |        |   | 2004                                               |   |        | 2005                       |  |   | 2006    |   |  | 2007 |         |   |   
|                                                                                                       |  | A$                                                 |        |   | A$                                                 |   |        | A$                         |  |   | A$      |   |  | A$   |         |   | A$ |   |         | U.S.$ | 
|                                                                                                       |  | (in thousands, except per share and footnote data) |        |   |                                                    |  
|Statement of Operations Data:                                                                          |  |                                                    |        |   |                                                    |   |        |                            |  |   |         |   |  |      |         |   |    |   |         |       |  |   |         |   |  |   |         |  
|Revenue                                                                                                |  | $                                                  |       |   |                                                    | $ |       |                            |  | $ |        |   |  | $    | 8       |   |    | $ | 205     |       |  | $ | 213     |   |  | $ | 174     |  
|Cost of goods sold                                                                                     |  |                                                    |       |   |                                                    |   |       |                            |  |   |        |   |  |      | 2       |   |    |   | 49      |       |  |   | 51      |   |  |   | 42      |  
|                                                                                                       |  |                                                    |        |   |                                                    |   |        |                            |  |   |         |   |  |      |         |   |    |   |         |       |  |   |         |   |  |   |         |  
|Gross profit                                                                                           |  |                                                    |       |   |                                                    |   |       |                            |  |   |        |   |  |      | 6       |   |    |   | 156     |       |  |   | 162     |   |  |   | 132     |  
|Operating expenses:                                                                                    |  |                                                    |        |   |                                                    |   |        |                            |  |   |         |   |  |      |         |   |    |   |         |       |  |   |         |   |  |   |         |  
|Research and development(1)                                                                            |  |                                                    | 925    |   |                                                    |   | 4,806  |                            |  |   | 7,885   |   |  |      | 14,982  |   |    |   | 21,177  |       |  |   | 50,824  |   |  |   | 17,981  |  
|General and administrative                                                                             |  |                                                    | 981    |   |                                                    |   | 2,182  |                            |  |   | 3,105   |   |  |      | 4,005   |   |    |   | 3,973   |       |  |   | 14,528  |   |  |   | 3,373   |  
|Commercial                                                                                             |  |                                                    |       |   |                                                    |   |       |                            |  |   | 807     |   |  |      | 1,764   |   |    |   | 2,814   |       |  |   | 5,385   |   |  |   | 2,389   |  
|Amortization of intangible assets                                                                      |  |                                                    | 86     |   |                                                    |   | 89     |                            |  |   | 90      |   |  |      | 136     |   |    |   | 95      |       |  |   | 716     |   |  |   | 81      |  
|Fair value of stock options issued to employees related to:                                            |  |                                                    |        |   |                                                    |   |        |                            |  |   |         |   |  |      |         |   |    |   |         |       |  |   |         |   |  |   |         |  
|Research and development                                                                               |  |                                                    | 261    |   |                                                    |   | 253    |                            |  |   | 115     |   |  |      | 613     |   |    |   | 569     |       |  |   | 1,935   |   |  |   | 483     |  
|Commercial                                                                                             |  |                                                    |       |   |                                                    |   |       |                            |  |   | 116     |   |  |      | 175     |   |    |   | 276     |       |  |   | 567     |   |  |   | 234     |  
|General and administrative                                                                             |  |                                                    | 122    |   |                                                    |   | 279    |                            |  |   | 29      |   |  |      | 335     |   |    |   | 643     |       |  |   | 1,505   |   |  |   | 546     |  
|                                                                                                       |  |                                                    |        |   |                                                    |   |        |                            |  |   |         |   |  |      |         |   |    |   |         |       |  |   |         |   |  |   |         |  
|Total operating expenses                                                                               |  |                                                    | 2,375  |   |                                                    |   | 7,609  |                            |  |   | 12,147  |   |  |      | 22,011  |   |    |   | 29,547  |       |  |   | 75,460  |   |  |   | 25,087  |  
|                                                                                                       |  |                                                    |        |   |                                                    |   |        |                            |  |   |         |   |  |      |         |   |    |   |         |       |  |   |         |   |  |   |         |  
|Loss from operations                                                                                   |  |                                                    | (2,375 | ) |                                                    |   | (7,609 | )                          |  |   | (12,147 | ) |  |      | (22,005 | ) |    |   | (29,391 | )     |  |   | (75,298 | ) |  |   | (24,955 | )
|Interest and other income                                                                              |  |                                                    | 327    |   |                                                    |   | 1,123  |                            |  |   | 1,702   |   |  |      | 4,282   |   |    |   | 5,278   |       |  |   | 12,816  |   |  |   | 4,482   |  
|Foreign currency gain (loss)                                                                           |  |                                                    |       |   |                                                    |   |       |                            |  |   |        |   |  |      | (5      | ) |    |   | (47     | )     |  |   | (52     | ) |  |   | (40     | )
|Amortization of preference share issue expenses                                                        |  |                                                    | (65    | ) |                                                    |   | (161   | )                          |  |   |        |   |  |      |        |   |    |   |        |       |  |   | (226    | ) |  |   |        |  
|                                                                                                       |  |                                                    |        |   |                                                    |   |        |                            |  |   |         |   |  |      |         |   |    |   |         |       |  |   |         |   |  |   |         |  
|Net loss before tax                                                                                    |  | $                                                  | (2,113 | ) |                                                    | $ | (6,647 | )                          |  | $ | (10,445 | ) |  | $    | (17,728 | ) |    | $ | (24,160 | )     |  | $ | (62,760 | ) |  | $ | (20,513 | )
|Income tax expense                                                                                     |  |                                                    |       |   |                                                    |   |       |                            |  |   |        |   |  |      | (5      | ) |    |   | (19     | )     |  |   | (24     | ) |  |   | (16     | )
|Net loss                                                                                               |  | $                                                  | (2,113 | ) |                                                    | $ | (6,647 | )                          |  | $ | (10,445 | ) |  | $    | (17,733 | ) |    | $ | (24,179 | )     |  | $ | (62,760 | ) |  | $ | (20,529 | )
|                                                                                                       |  |                                                    |        |   |                                                    |   |        |                            |  |   |         |   |  |      |         |   |    |   |         |       |  |   |         |   |  |   |         |  
|Basic and diluted net loss per share                                                                   |  | $                                                  | (0.19  | ) |                                                    | $ | (0.09  | )                          |  | $ | (0.08   | ) |  | $    | (0.11   | ) |    | $ | (0.14   | )     |  |   |         |   |  | $ | (0.12   | )
|                                                                                                       |  |                                                    |        |   |                                                    |   |        |                            |  |   |         |   |  |      |         |   |    |   |         |       |  |   |         |   |  |   |         |  
|Weighted average number of ordinary shares used in calculating basic and diluted net loss per share(3) |  |                                                    | 11,200 |   |                                                    |   | 75,744 |                            |  |   | 123,933 |   |  |      | 160,349 |   |    |   | 177,285 |       |  |   |         |   |  |   | 177,285 |  
|                                                                                                       |  |                                                    |        |   |                                                    |   |        |                            |  |   |         |   |  |      |         |   |    |   |         |       |  |   |         |   |  |   |         |  

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|(1) | Research and development expenses have been reduced by government research grants of A$751,000, A$1,105,000, A$1,132,000, A$1,245,000, A$1,955,000 and A$7,751,000 in fiscal 2003,
2004, 2005, 2006 and 2007, and the period from inception (May 29, 1998) to June 30, 2007, respectively.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | The amounts have been translated into U.S. dollars from Australian dollars based upon the noon buying rates in New York City as determined by the Federal Reserve Bank of New York on
June 30, 2007, which was A$1.00 to U.S.$0.8491. These translations are merely for the convenience of the reader and should not be construed as representations that the Australian dollar amounts actually represent such U.S. dollar amounts or
could be converted into U.S. dollars at the rate indicated.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | Fiscal 2003 and 2004, and the period from inception (May 29, 1998) to June 30, 2007, have been retroactively adjusted for an eight-for-one share split effected
in November 2003. The increase in ordinary shares in fiscal 2004 is attributable to our Australian initial public offering in which a total of 50,000,000 new ordinary shares were issued, and immediately before which 46,816,000 convertible redeemable
preference shares converted to ordinary shares on a one-for-one basis. The increase in ordinary shares in fiscal 2005 is primarily attributable to a share placement and share purchase plan in which a total of 26,362,092 new ordinary shares were
issued. The increase in ordinary shares in fiscal 2006 is primarily attributable to a U.S. public offering and a concurrent Australian share placement in which a total of 39,400,000 new ordinary shares were issued. In addition, 2,733,500 shares were
issued in fiscal 2006 upon the exercising of stock options by management or employees under the Companys employee option plan (Employee Option Plan). The increase in 2007 is primarily the
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | full year effect of shares issued in fiscal 2006. In addition, 1,045,625 shares were issued in fiscal 2007 upon the exercising of stock options by management
or employees under the Companys Employee Option Plan.
| | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|                                            |  |                |        |   |      |   |        |  |      |        |      |   |          |  |   |        |  |   |       
|------------------------------------------- |  | -------------- | ------ | - | ---- | - | ------ |  | ---- | ------ | ---- | - | -------- |  | - | ------ |  | - | ------
|                                            |  | As of June 30,
|                                            |  | 2003           |        |   | 2004 |   | 2005   |  | 2006 |        | 2007 |   | 2007    
|                                            |  | A$             |        |   | A$   |   | A$     |  | A$   |        | A$   |   | U.S.$(2)
|                                            |  | (in thousands) |        |  
|Balance Sheet Data:                         |  |                |        |   |      |   |        |  |      |        |      |   |          |  |   |        |  |   |       
|Cash and cash equivalents                   |  | $              | 7,384  |   |      | $ | 25,101 |  | $    | 33,268 |      | $ | 97,840   |  | $ | 76,182 |  | $ | 64,686
|Total assets                                |  |                | 10,459 |   |      |   | 28,111 |  |      | 37,836 |      |   | 104,213  |  |   | 82,642 |  |   | 70,171
|Convertible redeemable preference shares(1) |  |                | 11,630 |   |      |   |       |  |      |       |      |   |         |  |   |       |  |   |      
|Total shareholders (deficit) equity        |  |                | (1,776 | ) |      |   | 26,631 |  |      | 35,467 |      |   | 98,888   |  |   | 76,559 |  |   | 65,006

---

|(1) | Convertible redeemable preference shares were converted to ordinary shares immediately prior to the quotation of our ordinary shares on the Australian Securities Exchange after our
Australian initial public offering in November 2003.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | The amounts have been translated into U.S. dollars from Australian dollars based upon the noon buying rates in New York City as determined by the Federal Reserve Bank of New York on
June 30, 2007, which was A$1.00 to U.S.$0.8491. These translations are merely for the convenience of the reader and should not be construed as representations that the Australian dollar amounts actually represent such U.S. dollar amounts or
could be converted into U.S. dollars at the rate indicated.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Exchange Rate Information:

The following tables present exchange rates of the Australian dollar into the U.S. dollars for the periods indicated. Annual averages are calculated using
the average of month-end rates of the relevant year. Monthly averages are calculated using the average of the daily rates during the relevant period.



|                                                      |  |         |  |        |  |       
|----------------------------------------------------- |  | ------- |  | ------ |  | ------
|Period                                                |  | Average |  | High   |  | Low   
|                                                      |  | U.S.$   |  | U.S.$  |  | U.S.$ 
|Five most recent fiscal years                         |  |         |  |        |  |       
|2003                                                  |  | 0.5884  |  | 0.6729 |  | 0.5280
|2004                                                  |  | 0.7155  |  | 0.7979 |  | 0.6390
|2005                                                  |  | 0.7568  |  | 0.7974 |  | 0.6880
|2006                                                  |  | 0.7472  |  | 0.7781 |  | 0.7056
|2007                                                  |  | 0.7925  |  | 0.8491 |  | 0.7407
|Six most recent months                                |  |         |  |        |  |       
|May 2007                                              |  | 0.8254  |  | 0.8348 |  | 0.8190
|June 2007                                             |  | 0.8423  |  | 0.8491 |  | 0.8313
|July 2007                                             |  | 0.8677  |  | 0.8841 |  | 0.8509
|August 2007                                           |  | 0.8291  |  | 0.8618 |  | 0.7860
|September 2007                                        |  | 0.8477  |  | 0.8855 |  | 0.8238
|October 2007                                          |  | 0.8996  |  | 0.9271 |  | 0.8785
|As of November 9, 2007, the exchange rate was $0.9145 |  |         |  |        |  |       



|B. | Capitalization and Indebtedness
|-- | -------------------------------

Not applicable.



|C. | Reasons for the Offer and Use of Proceeds
|-- | -----------------------------------------

Not
applicable.



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|D. | Risk Factors
|-- | ------------

The following risks relate
specifically to the Companys business and should be considered carefully. Our business, financial condition and results of operations could be materially and adversely affected by any of the following risks. As a result, the trading
price of our ordinary shares and our American Depositary Shares, or ADSs, could decline and the holders could lose part or all of their investment.

Risks Related to Our Business

We are at an early stage of our development as a specialist integrated pharmaceutical company. Our
first product, Aridol, has commenced generating initial revenue in a limited number of jurisdictions. We may not be successful in deriving meaningful revenues from Aridol. We do not currently have, and we may never have, any other products other
than Aridol that generate revenues. Unless we are able to generate sufficient product revenue, we will continue to incur losses from operations and may not achieve or maintain profitability.

We are at an early stage of our development as a specialist integrated pharmaceutical company. We were incorporated in May 1998 and we have a limited
operating history on which to evaluate our business and prospects. To date, we do not have, and we may never have, any products that generate significant revenues. We have launched our first product, Aridol, in a limited number of jurisdictions
including Australia and Sweden. We have generated a small amount of revenue from Aridol in these jurisdictions to date. We have funded our operations primarily through the private sales of our securities, the initial public offering of our
securities in Australia and the U.S. and a share purchase plan. We have also received funding from government research grants and earned interest income on invested funds.

We have incurred losses in each year since our inception and expect to continue to incur substantial losses. We incurred losses of approximately A$10.4
million, A$17.7 million and A$24.2 million in the fiscal years ended June 30, 2005, 2006 and 2007, respectively. Our accumulated losses from inception to June 30, 2007 are A$62.8 million. These losses, among other things, have had, and
will continue to have, an adverse effect on our shareholders equity and working capital. Unless we are able to generate sufficient product revenue, we will continue to incur losses from operations and may not achieve or maintain profitability.

We expect our expenses to increase significantly in the short term in connection with:



| |  |  | the regulatory marketing authorization process to approve the sale of Aridol in the U.S. and parts of the European Union, or E.U., and other jurisdictions. Aridol
was the first of our product candidates to complete Phase III trials in any jurisdiction and the first of our product candidates for which we have sought marketing authorization. We have to date received marketing authorization in Australia and 14
European countries. The work involved in seeking regulatory marketing authorization for Aridol in other jurisdictions, including the U.S., is extensive, time consuming and expensive;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the development of our Aridol sales and marketing capability. Our existing sales and marketing capability is currently limited to a sales team for Australia, six
distributors in Europe, and a European office to oversee and service our European distributors. To date our sales and marketing capability has not represented a significant cost to us. Our sales and marketing capability must be increased to enable
the sales and marketing of Aridol in U.S. and to expand sales in Europe and Australia;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the continuation of simultaneous Phase III clinical trials of Bronchitol for different chronic respiratory disorders. These clinical trials are carried out in a
number of jurisdictions and with respect to a number of indications and are expensive. Our first Phase III study of Bronchitol for the treatment of people with bronchiectasis has recently been completed;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our expenses will increase as we commence new clinical trials and progress existing trials to more advanced phases and/ or additional sites. The more advanced
clinical trials typically require more clinical trial participants, clinical trial sites and research investigators than earlier stage clinical trials and are consequently more expensive;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | the commencement of Phase I clinical trials of PXS25/64, which will represent a significant new expense for us;
| | - |  | ---------------------------------------------------------------------------------------------------------------



| |  |  | although we already have existing expenses associated with the preclinical testing of several product candidates, in the short term, we will continue to incur
expenses as a result of preclinical testing of product candidates and any other clinical trials and preclinical testing that we may initiate; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the establishment of a number of early stage research and development projects being undertaken by or on behalf of the Company.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------

We also expect to incur increased general and administrative expenses in support of our increased operations as well as the ongoing costs to operate as a
company listed on the Australian Securities Exchange and on the Nasdaq Global Market.

Over the longer term, the costs referred to above
will fluctuate, primarily dependant on the number and type of clinical trials being undertaken by us at any one time, regulatory marketing authorizations being sought, the extent of our sales and marketing operations and the research and development
projects being undertaken . Costs will also increase if we are able to progress any further clinical trial candidates from preclinical testing to clinical trials or if we are able to complete clinical trials of any product candidates and seek
regulatory marketing authorizations.

We may not become profitable if Bronchitol is unsuccessful in ongoing clinical trials or we are unable to obtain
regulatory approvals for Aridol and Bronchitol in key jurisdictions. Even though we have received regulatory approval for Aridol in a number of jurisdictions and may receive regulatory approval for Aridol and other product candidates in other
jurisdictions, profitability will depend on our ability to generate revenues from the sale of our products or the licensing of our technology.

We cannot be certain of the success of our clinical development of Bronchitol or any of our other product candidates in preclinical testing or clinical development will be successful, that any of our products or product candidates will
receive the regulatory approvals required to commercialize them, or that any of our research and development programs will yield additional product candidates suitable for investigation through clinical trials.

Our Phase III study of Bronchitol for the treatment of people with bronchiectasis for Europe and Australia has recently been completed and the study met
its two primary efficacy endpoints, being quality of life and mucus clearance. However, we cannot be certain that results of the study will enable marketing approval to be granted in any jurisdiction. We will undertake continuing clinical trials of
Bronchitol for the treatment of people with bronchiectasis in the U.S. In addition we will continue simultaneous clinical trials of Bronchitol for the treatment of cystic fibrosis and chronic bronchitis. If Bronchitol is unsuccessful in these and
other ongoing clinical trials, or we are unable to obtain marketing authorization of our products and product candidates in all key jurisdictions, we may not be profitable. Clinical trials of Bronchitol will continue for several years, but may take
significantly longer to complete. There is a risk that these clinical trials of Bronchitol may not be successful or that marketing approval may not be granted in the future. If we are not able to successfully complete clinical trials of Bronchitol,
and if we are unable to obtain marketing authorization of Bronchitol, we may not be profitable. If we are unable to obtain marketing authorization of Aridol in the U.S. and other key jurisdictions, we may not be profitable.

Likewise, if we are unable to obtain marketing authorization of our products and product candidates in all key jurisdictions, we may not be profitable.
We have completed the Phase III clinical trials of Aridol necessary for U.S. registration of Aridol. However, we cannot be certain that marketing approval will be granted in the U.S. There is a risk that these Phase III clinical trials in the U.S.
may not be sufficient and that marketing authorization may not be granted in the U.S.

The process to develop, obtain regulatory approval
for, and commercialize potential product candidates is long, complex and costly. Even if we receive regulatory approval for any product candidates, profitability will depend on our ability to generate revenues from the sale of our products or the
licensing of our technology that will offset the significant and continuing expenditures required for us to advance our research, protect and extend our



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intellectual property rights and develop, manufacture, license, market, distribute and sell our technology and products successfully. Our ability to generate
revenue depends on a number of factors, including our ability to:



| |  |  | successfully conduct and complete clinical trials for Bronchitol and our other product candidates;
| | - |  | --------------------------------------------------------------------------------------------------



| |  |  | develop and obtain all necessary regulatory marketing authorization, as well as approvals concerning pricing and reimbursement, which may be necessary in some of
the E.U. member states, for Aridol and Bronchitol in our target markets where we do not currently have regulatory marketing authorization and, in the future, to develop and obtain regulatory marketing authorization for our other product candidates;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | manufacture or obtain commercial quantities of Aridol and Bronchitol or our other product candidates at acceptable cost levels; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------



| |  |  | successfully market and sell Aridol, Bronchitol and our other product candidates. In circumstances where we have licensed our technology to third parties, our
ability to generate revenue will depend on the success of the licensor of the technology to successfully market and sell the licensed technology.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Although we have a pipeline of potential product candidates, our business is currently substantially dependent on our ability to complete development, obtain regulatory approval for, and successfully commercialize
Aridol and Bronchitol in a timely manner. If we are unable to successfully commercialize Aridol and/or Bronchitol, we may not be able to earn sufficient revenues to continue our business. If we fail to become and remain profitable, or if we are
unable to fund our continuing losses, there would be a material adverse effect on our business and the holders of our ordinary shares and ADSs could lose all or part of their investment.

Unsuccessful or delayed marketing authorization could increase our future development costs or impair our future revenue. Approvals that may be given may not cover all the indications for which we seek approval or
may contain significant limitations.

To receive regulatory marketing authorization for the commercial sale of our product candidates,
we must conduct preclinical studies and clinical trials to demonstrate safety and efficacy in humans. This process of attempting to gain regulatory approval is expensive and can take many years, and failure can occur at any stage of the testing. We
have received regulatory marketing authorization for Aridol in certain target markets including Australia and 14 European countries. Our failure to adequately demonstrate the safety and efficacy of Aridol in our other target markets and/or our
failure to adequately demonstrate the safety and efficacy of Bronchitol for the treatment of various chronic respiratory disorders and/or any of our other product candidates or otherwise fail to satisfy regulatory requirements will prevent
regulatory approval and commercialization of such product candidates. Our inability to successfully and effectively complete clinical trials for our product candidates, in particular clinical trials of Bronchitol, will severely harm our business and
we may not be profitable.

Significant delays in clinical development could materially increase our product development costs, delay our
receipt of revenue or allow our competitors to bring product candidates to market before we do, impairing our ability to effectively commercialize Aridol and Bronchitol or our other product candidates.

In addition, any authorization we may obtain may not cover all of the clinical indications for which we seek approval. Also, an authorization might
contain significant limitations in the form of narrow indications, warnings, precautions or contraindications with respect to conditions of use.

We
will continue to need significant amounts of additional capital that may not be available to us on favorable terms or at all or which may be dilutive.

To date, we have funded our operations and capital expenditures with proceeds from the sale of our securities, government grants and interest on investments.

In order to achieve our goal of being a fully integrated pharmaceutical company and to conduct the lengthy and expensive research, preclinical studies,
clinical trials, regulatory approval process, manufacture, sales and marketing necessary to complete the full development of our product candidates, we may require substantial additional funds in addition to the funds received in connection with the
U.S. public offering and the Australian placement completed in November 2005. In particular, we may require substantial additional funding as a result of



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our strategy of building a specialist international fully integrated pharmaceutical company and not always entering into strategic alliances or partnerships
in order to commercialize our product candidates.

To meet these financing requirements, we may raise funds through public or private
equity offerings, debt financings, and through other means, including collaborations and license agreements. Raising additional funds by issuing equity or convertible debt securities may cause our shareholders to experience significant additional
dilution in their ownership interests. Raising additional funds through debt financing, if available, may involve covenants that restrict our business activities. Additional funding may not be available to us on favorable terms, or at all. If we are
unable to obtain additional funds, we may be forced to delay, reduce the scope or terminate our clinical trials and the development, manufacturing and marketing of our products. To the extent that we raise additional funds through collaborations and
licensing arrangements, we may have to relinquish valuable rights and control over our technologies, research programs or product candidates, or grant licenses on terms that may not be favorable to us.

If we fail to obtain additional financing, we may be unable to fund our operations and commercialize our product candidates.

We expect that our cash expenditure will increase for the next several years, and that we will spend substantial amounts to complete the clinical
development and commercialization of Aridol, Bronchitol, PXS25/64 and our other product candidates, and to license or acquire other product candidates. We believe that our existing cash and cash equivalents will be sufficient to meet our projected
operating requirements for at least 12 months.

Our future funding requirements will depend on many factors, including the scope, results,
rate of progress, timing and costs of preclinical studies and clinical trials and other development activities. The funding requirements for clinical trials of Aridol, Bronchitol and PXS25/64 are significant. The funding requirements for the
preclinical testing and potential future clinical testing of our product candidates and any other testing that we may initiate is also significant;



| |  |  | costs and timing of seeking and obtaining regulatory approvals;
| | - |  | ---------------------------------------------------------------



| |  |  | costs of filing, prosecuting, defending and enforcing any patent claims and other intellectual property rights;
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| |  |  | costs of developing our sales and marketing capabilities and establishing distribution capabilities;
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| |  |  | costs of expanding our manufacturing capabilities to satisfy demand for our products;
| | - |  | -------------------------------------------------------------------------------------



| |  |  | costs of additional management and scientific, manufacturing and sales and marketing personnel. We will be required to increase the number of our personnel over
time;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | terms, timing and cash requirements of any future acquisitions, collaborative arrangements, licensing of product candidates or investing in businesses, product
candidates and technologies;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | costs of securing coverage, payment and reimbursement of our product candidates which receive regulatory approval; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------



| |  |  | effects of competing clinical, technological and market developments.
| | - |  | ---------------------------------------------------------------------

If we are not able to secure additional funding when needed, we may have to delay, reduce the scope of, or eliminate one or more of our clinical trials
or research and development programs or future commercialization efforts.

We may be required to repay previously received grant revenue in certain
circumstances which would have an adverse effect on our cash position.

We have received substantial grant funding under a grant
agreement with the Commonwealth of Australia. There is a risk that we will not be entitled to the grant payments for failing to incur eligible expenditure or failing to undertake activities associated with the grant or otherwise for failing to
satisfy the relevant conditions in the grant agreement. Furthermore, there is a risk we will not be entitled to the funds under the grant agreement, including, if the Commonwealth of Australia has insufficient funding for the relevant grant program,
if we fail to submit reports when required, if we have not otherwise complied with our obligations under the funding agreement, or if the



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Commonwealth of Australia is entitled to or does terminate the relevant agreement. The Commonwealth of Australia may terminate the grant agreements on
different bases, including by giving us written notice of termination if we are in breach of the agreement and if in the opinion of the Commonwealth of Australia the breach is not capable of being remedied or if capable of being remedied it is not
remedied after receipt of written notice, if we fail to submit reports, if our research and development activities or the quality of those activities do not satisfy the grant eligibility criteria, if there is a change of control of us or if we
become insolvent.

In certain circumstances where we fail to use our best endeavors to commercialize the project within a reasonable time
of completion of the project or upon termination of a grant due to our breach of agreement or our insolvency, the Commonwealth of Australia may require us to repay some, or all, of the grant. If required to repay the grant amounts, we may be
required to reallocate funds needed to continue the commercialization of our products and such repayment may have a material adverse effect on our cash position and us.

Currency fluctuations may expose us to increased costs and revenue decreases.

Our business may in
the future be affected by fluctuations in foreign exchange rates. Currency fluctuations could, therefore, cause our costs to increase and revenues to decline. The majority of our expenses will continue to be denominated in Australian dollars
although we will also be expending cash in other denominations, including the U.S. dollar, British pound, Swedish krona, Danish krona and the European euro. The exchange rates of the Australian dollar to the U.S. dollar, the British pound, the
Swedish krona and the European euro have fluctuated in recent years. In circumstances where the Australian dollar devalues against any or all of the U.S. dollar, the British pound, the Swedish krona or the European euro, this may have an adverse
effect on our costs incurred in either the U.S. or Europe (as applicable) but may have a positive effect on any revenues which we source from the U.S. or Europe (as applicable). The same principles apply in respect of our costs and revenues in other
jurisdictions. In addition, we conduct clinical trials in many different countries and we have manufacturing of some of our product candidates undertaken outside of Australia, which exposes us to potential cost increases resulting from fluctuations
in exchange rates. We do not currently have any plans to hedge the effect of currency fluctuations on our overseas expenditures. We manage our currency risks by settling foreign currency payables immediately upon recognition of a foreign currency
liability and/or by holding foreign currency cash funds to match net foreign currency payables.

Risks Related to Research and Development of Our
Products

Clinical trials are expensive, time consuming, subject to delay and their outcome is uncertain and may not be completed at all.

Before we can obtain regulatory authorization for the commercial sale of any product or product candidate, we are required to complete
preclinical development and extensive clinical trials in humans to demonstrate its safety and efficacy. Preclinical development and clinical trials are subject to extensive regulation by the U.S. Food and Drug Administration, or FDA, and other
regulatory authorities in the U.S., the E.U., Australia and elsewhere. In addition, clinical trials must be conducted with product candidates produced under applicable current Good Manufacturing Practices. Clinical trials are expensive and complex,
can take many years, are often subject to delay and have uncertain outcomes. The FDA has accepted an Investigational New Drug Application, or IND, for inhaled dry powdered mannitol. We have completed the Phase III clinical trials of Aridol that we
believe are necessary for U.S. marketing authorization of Aridol. Our Phase III study of Bronchitol for Europe and Australia for the treatment of people with bronchiectasis has recently been completed and the study met its two primary efficacy
endpoints, being quality of life and mucus clearance. We have reached agreement with the FDA in relation to a protocol for a U.S. Phase III trial in subjects with cystic fibrosis and are in discussions with the FDA in relation to the protocol for
the U.S. Phase III trial in subjects with bronchiectasis. Clinical trials of our product candidates, Bronchitol and PXS25/64, will continue for several years, but may take significantly longer to complete. We are also likely to undertake continuing
trials of Aridol.

There are numerous factors that could affect the timing of the commencement, continuation and completion of clinical
trials which may delay the clinical trials or prevent us from completing these trials successfully, including but not limited to:



| |  |  | delays in securing clinical investigators or trial sites for our clinical trials, scheduling conflicts with participating clinicians and clinical institutions, and
delays in obtaining institutional review board, or IRB, and other regulatory approvals to commence a clinical trial. There are a limited number of clinical
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| | investigators and clinical trials sites worldwide able to conduct the clinical trials required by us. Clinical investigators and trial sites may have demands
from a number of companies competing to use their resources;
| | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | slower than anticipated recruitment and enrollment of patients who meet the trial eligibility criteria or the loss of patients during the course of the clinical
trials. By way of example, we experienced delays on our Bronchitol Phase II clinical trials for the treatment of cystic fibrosis because recruitment was slower than anticipated. We managed the enrollment problem by modifying the protocol to widen
the eligibility of clinical trial participants, adding additional clinical trial sites and assisting with resourcing at clinical trial sites. We may not be able to successfully manage such enrollment problems in the future;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the requirement to repeat or undertake large clinical trials. Our Phase II and Phase III clinical trials involve a large number of patients and are typically
carried out in different jurisdictions and may also need to be repeated if required by regulatory authorities;
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| |  |  | negative or inconclusive results from clinical trials, or deficiencies in the conduct of the clinical trials may require us to repeat clinical trials;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | unforeseen safety issues or unforeseen adverse side effects or fatalities or other adverse events arising during a clinical trial due to medical problems that may
or may not be related to clinical trial treatments;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the product candidate may not be competitive with current therapies. For example, Aridol must prove to be convenient and effective as a test for airway
hyper-responsiveness, which assists in the identification of and determines the severity of asthma. In addition, Bronchitol must improve the quality of life and health of people with chronic obstructive lung diseases such as bronchiectasis, cystic
fibrosis and chronic bronchitis;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | quality or stability of the product candidate may fall below acceptable standards;
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| |  |  | shortages of available product supply. We may be required to simultaneously provide product to patients in a range of jurisdictions and there may be shortages or
delays in supplying the product in those jurisdictions;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | uncertain dosing issues; and
| | - |  | ----------------------------



| |  |  | inability to monitor patients adequately during or after treatment or problems with investigator or patient compliance with the trial protocols.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------

Due to the foregoing and other factors, the regulatory approval of Aridol in the U.S. or in other key markets where we
do not currently have marketing approval of Aridol, as well as the regulatory approval of Bronchitol, PXS25/64 and any of our other future product candidates, could take a significantly longer time to gain regulatory approval than we expect or these
products may never gain approval or may only gain approval in some but not all jurisdictions, which could reduce or eliminate our revenue by delaying or terminating the potential commercialization of our products or product candidates. If we suffer
any significant delays, setbacks or negative results in, or termination of, our clinical trials, we may be unable to continue the development of our products or product candidates or generate revenue and our business may be materially adversely
affected.

Ongoing and future clinical trials of our product candidates may not show sufficient safety or efficacy to obtain requisite regulatory
approvals.

Ongoing and future clinical trials of our product candidates may not show sufficient safety or efficacy to obtain
regulatory approval for marketing. Phase I and Phase II clinical trials are not primarily designed to test the efficacy of a product candidate but rather to test safety, to study pharmacokinetics and pharmacodynamics and to understand the product
candidates side effects at various doses and schedules. Furthermore, success in preclinical and early clinical trials does not ensure that later large-scale trials will be successful nor does it predict final results. Acceptable results in
early trials may not be repeated in later trials. There is a risk that the final results of Phase III clinical trials may not show sufficient safety or efficacy to obtain regulatory approval for marketing approval in the U.S. despite the completion
of Phase III trials in other jurisdictions and the granting of marketing authority in other



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jurisdictions. Likewise, clinical trials of product candidates may not show sufficient safety or efficacy to obtain regulatory approval for marketing.

We may conduct lengthy and expensive clinical trials of our product candidates, only to learn that the product candidate is not an
effective treatment. A number of companies in the biotechnology and pharmaceutical industries have suffered significant setbacks in advanced clinical trials, even after promising results in earlier trials. In addition, clinical results are
frequently susceptible to varying interpretations that may require trials to be redone or delay, limit or prevent regulatory approvals. Negative or inconclusive results or adverse medical events during a clinical trial could cause the clinical trial
to be delayed, redone or terminated. In addition, failure to construct appropriate clinical trial protocols or other factors could result in the test or control group experiencing a disproportionate number of adverse events and could cause a
clinical trial to be redone or terminated. The length of time necessary to complete clinical trials and to submit an application for marketing approval for a final decision by applicable regulatory authorities may also vary significantly based on
the type, complexity and novelty of the product candidate involved, as well as other factors.

Due to our reliance on contract research organizations,
hospitals and investigators to conduct clinical trials, we are unable to directly control the timing, conduct and expense of our clinical trials. We also use third parties to provide research and development services and do not have direct control
of the timing, conduct and expense of certain of our research programs.

We rely on third parties such as contract research
organizations, hospitals and research investigators to provide services in connection with our clinical trials. Our clinical trials are conducted by a number of third parties at a number of different sites in different jurisdictions.

We believe that the agreements that we enter into with these third parties are customary for agreements relating to the provision of clinical trial
services. The agreements set out the parameters and protocols for the relevant clinical trials, set out the amount payable by us, as well as setting out the rights and obligations of the third parties and us.

To date, we have been able to manage the use of these third parties in order to effectively carry out our clinical trials. If these third parties do not
successfully carry out their contractual duties or regulatory obligations or meet expected deadlines, if the third parties need to be replaced or if the quality or accuracy of the data they obtain is compromised due to the failure to adhere to our
clinical protocols or regulatory requirements or for other reasons, our clinical trials may be extended, delayed, suspended or terminated, and we may not be able to obtain regulatory approval for or successfully commercialize our product candidates.
Although there are a range of suitable institutions and investigators that would be able to conduct the clinical trials on our behalf, there is no guarantee that we will be able to enter into any such arrangement on acceptable terms, if at all.

Risks Related to the Manufacture of Our Products

The failure to secure an adequate supply of the inhalers to be used in the administration of Aridol and Bronchitol could compromise the commercialization of Aridol and Bronchitol.

Both Aridol and Bronchitol are administered through a dry powder inhaler. If we are not able to enter into a supply agreement or the number of inhalers
supplied are inadequate to meet patient demand, we would be subject to costly delays which may compromise the commercialization of Aridol and/or Bronchitol. The supply of inhalers may be delayed or we may need to change our supplier of inhalers
which could delay the commercialization of Aridol and/or Bronchitol.

Delays in the supply of the necessary quantity or quality of mannitol could
compromise the commercialization of our products.

Any delays in the supply of the necessary quantity or quality of mannitol for the
manufacture of Aridol and Bronchitol could compromise the commercialization of our products. The supply of mannitol may be delayed, or we may need to change our supplier of mannitol, which could potentially result in delays to the supply of the
product to clinical trials and for sale while we sourced alternative suppliers of mannitol.



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We currently have limited manufacturing capacity and outsource some manufacturing for the clinical development and
commercial production of our products, all of which puts us at risk of lengthy and costly delays of bringing our products to market.

We currently operate manufacturing facilities in Sydney, Australia. Our manufacturing facilities are licensed by the Australian Therapeutic Goods Administration, or TGA, to manufacture Good Manufacturing Practice grade material for
commercial sale. We have outsourced the manufacturing of Good Manufacturing Practice grade PXS25/64 for preclinical trials and clinical trials as our manufacturing facilities are not suitable for the production of PXS25/64.

We have recently entered into an agreement concerning the lease of a purpose built manufacturing, warehousing and office facility. Construction of the
new facility is expected to commence in the fourth quarter of 2007 and is expected to take approximately twelve months to complete. We will be subject to significant undetermined risks associated with the building of these new facilities, including
delays in construction and disputes in connection with the construction, which may delay or severely compromise the commercialization of our products and our results and operations may be harmed. There is also a risk of delays to our research and
clinical trial activities if we needed to change our existing outsourced manufacturers of PXS25/64.

We may fail to achieve and maintain
required production yields or manufacturing standards which could result in patient injury or death, product recalls or withdrawals, product shortages, delays or failures in product testing or delivery or other problems that could seriously harm our
business. In addition, we are subject to ongoing inspections and regulation of regulatory authorities, including by the TGA and the FDA.

In
circumstances where we seek to outsource the manufacture of certain products, there is no guarantee that we will be able to enter into any such arrangement on acceptable terms, if at all, and as a result we are at risk of lengthy and costly delays
of bringing our products to market.

In circumstances where we seek to outsource the manufacture of certain product candidates, such as
PXS25/64, there is no guarantee that we will be able to enter into any such arrangement on acceptable terms, if at all. We may be required to enter into long-term manufacturing agreements that contain exclusivity provisions and/or substantial
termination penalties. To date, the agreements for the manufacture of preclinical quantities of PXS25/64 do not contain any such exclusivity provisions or termination penalties. In addition, contract manufacturers may have a limited number of
facilities in which our products can be produced and any interruption of the operation of those facilities could result in the cancellation of shipments and loss of product, resulting in delays and additional costs.

We, and our contract manufacturers, are required to produce our clinical product and commercial product under FDA and E.U. current Good Manufacturing
Practices in order to meet acceptable standards. If such standards change, our ability and the ability of contract manufacturers to produce our products when we require may be affected.

We will outsource the manufacturing of Good Manufacturing Practice grade PXS25/64 for Phase I clinical trials as our manufacturing facilities are not
suitable for the production of PXS25/64. Our existing manufacturers of PXS25/64 and any future contract manufacturers for PXS25/64 or any of our other product candidates which we seek to contract manufacture may not perform as agreed or may not
remain in the contract manufacturing business for the time required to successfully produce, store and distribute our products. We, or our contract manufacturers, may also fail to achieve and maintain required production yields or manufacturing
standards which could result in patient injury or death, product recalls or withdrawals, product shortages, delays or failures in product testing or delivery or other problems that could seriously harm our business. In addition, we are, and our
contract manufacturers are, subject to ongoing inspections and regulation of regulatory authorities, including by the TGA and the FDA.

The
ability to find an acceptable manufacturer or to change manufacturers may be difficult for a number of reasons, including that the number of potential manufacturers is limited and we may not be able to negotiate agreements with manufacturers on
commercially reasonable terms, the complex nature of the manufacturing process of certain of our product candidates, such as PXS25/64, which may require a significant learning curve for the



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manufacturer, and the FDA must approve any replacement manufacturer prior to manufacturing, which requires new testing and compliance inspections.

If we were required and able to change manufacturers, the FDA would also require that we demonstrate structural and functional
comparability between the same product manufactured by different organizations and may require comparability studies.

Risks Related to Marketing,
Distribution and Sales

If we are unable to expand our sales and marketing force our business may be harmed.

We currently have a limited number of sales and marketing staff and limited distribution capabilities including a sales force located in Australia, six
distributors in Europe, and a European office to oversee and service our European distributors. Our goal is to build an integrated pharmaceutical business undertaking research and development, clinical trials, sales and marketing for certain of our
product candidates. We are proposing to develop our sales and marketing capability for products which address highly concentrated markets served by specialist physicians. We intend to contract or partner with third parties in respect of sales and
marketing of products where the markets are larger, more diverse or less accessible. For our early stage products or any new products, we may form other strategic alliances with third parties, which have established distribution systems and sales
forces, in order to commercialize our products. We market Aridol directly in Australia, through distributors in Europe and, assuming receipt of all necessary approvals of Aridol for commercial sale, we intend to use a combination of direct marketing
to pulmonary specialists and third parties in the U.S.

We will need to incur significant additional expenses and commit significant
additional management resources to establish a sales and marketing force. Although we have already begun to develop our sales and marketing capability, we may not be able to successfully establish these capabilities despite these additional
expenditures. Even if we are successful in establishing a sales and marketing force, it may not be as effective as a third-party sales and marketing force. In circumstances where we elect to rely on third parties, we may receive less revenue than if
we sold such products directly. In addition, we may have little or no control over the sales efforts of those third parties and they may not perform as agreed. In the event we are unable to sell sufficient quantities of Aridol, Bronchitol and other
product candidates, either directly or through third parties, our business may be significantly harmed and we may be forced to delay, reduce the scope, or terminate our clinical trials and the development, manufacturing and marketing of our
products.

Our failure to establish and manage a distribution network for our products could delay or compromise the commercialization of Aridol and
Bronchitol and other products.

We have recently established systems and processes necessary for distributing products to customers in
Australia and to marketing/distribution partners in Europe. Failure to secure additional contracts with distributors could negatively impact the distribution of our products. If we are unable to effectively establish and manage the distribution
process, the commercialization of Aridol and Bronchitol and other products may be delayed or severely compromised and our results of operations may be harmed.

To the extent we are able to enter into collaborative arrangements or strategic alliances, we will be exposed to risks related to those collaborations and alliances.

Although our goal is to be a fully integrated pharmaceutical company, an important element of our strategy for developing, manufacturing and
commercializing our product candidates is entering into partnerships and strategic alliances with other pharmaceutical companies or other industry participants to advance our programs and enable us to maintain our financial and operational capacity.
We may not be able to negotiate alliances on acceptable terms, if at all. Although we do not believe any of the marketing or distribution agreements we have are currently material, such arrangements may become material in the future to the extent
any of them represents a significant source of our revenue. Although we are not currently party to any collaborative arrangement or strategic alliance that is material to our business, in the future we may rely on collaborative arrangements or
strategic alliances to complete the development and commercialization of some of our product candidates. These arrangements may result in us receiving less revenue than if we sold such products directly, may place the development, sales and
marketing of our products outside our control, may require us to relinquish important rights or may otherwise be on terms



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unfavorable to us. Collaborative arrangements or strategic alliances will subject us to a number of risks, including the risk that:



| |  |  | we may not be able to control the amount and timing of resources that our strategic partner/collaborators may devote to the product candidates;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our strategic partner/collaborators may experience financial difficulties;
| | - |  | --------------------------------------------------------------------------



| |  |  | we may be required to relinquish important rights such as marketing and distribution rights;
| | - |  | --------------------------------------------------------------------------------------------



| |  |  | business combinations or significant changes in a collaborators business strategy may also adversely affect a collaborators willingness or ability to
complete its obligations under any arrangement;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | a collaborator could independently move forward with a competing product developed either independently or in collaboration with others, including our competitors;
and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | collaborative arrangements are often terminated or allowed to expire, which would delay the development and may increase the cost of developing our product
candidates.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------

We face costs associated with importing our products into markets outside of Australia.

As much of our product is likely to be manufactured in Australia, we may face difficulties in importing our products into various jurisdictions as a
result of, among other things, import inspections, incomplete or inaccurate import documentation or defective packaging. There will be increased costs associated with importing/exporting our product.

Risks Relating to Competition

If our competitors are able
to develop and market products that are preferred over Aridol, Bronchitol or our other product candidates our commercial opportunity may be significantly reduced or eliminated.

We face competition from established pharmaceutical and biotechnology companies, as well as from
academic institutions, government agencies and private and public research institutions. We are seeking to develop and market products that will compete with other products and drugs that currently exist or are being developed or may be developed in
the future. For Aridol, various products and treatments are currently marketed for monitoring lung hyper-responsiveness and the identification and assessment of asthma, including methacholine (Provocholine®) by Methapharm, Inc. as a direct bronchiol provocation agent. We believe Aridol is the only airway hyper-responsive test developed using dry powder inhalation technology. This test may not be well accepted in the
market place or the medical community. Similarly, for Bronchitol, various products and treatments are currently marketed, including inhaled antibiotics, mucolytic agents and bronchodilators. Bronchitol may not work well in conjunction with existing
marketed therapies. In addition, a number of companies are developing new approaches for the treatment of cystic fibrosis, including new antibiotic preparations by Gilead Sciences, Inc. and Novartis AG. and new agents to restore salt balance from
Inspire Pharmaceuticals, Inc. and Gilead Sciences, Inc. In addition, many companies are interested in gene therapy. New antibiotic preparations are being tested in patients with bronchiectasis. For patients with chronic bronchitis, new
anti-inflammatory agents and new bronchodilating agents are under development.

Our commercial opportunity will be reduced or eliminated if
our competitors develop and commercialize products that are safer, more effective, have fewer side effects, are more convenient, are less expensive, or that reach the market sooner than our products. Scientific, clinical or technical developments by
our competitors may render Aridol and/or Bronchitol or our other product candidates obsolete or noncompetitive. Further, public announcements regarding the development of any such competing products could adversely affect the market price of our
ordinary shares or ADSs. We anticipate that we will face increased competition in the future as new companies enter the markets and as scientific developments progress. If our products obtain regulatory approvals, but do not compete effectively in
the marketplace, our business will suffer.

Many of our competitors currently have significantly greater financial resources and expertise
in conducting clinical trials, obtaining regulatory approvals, undertaking and managing manufacturing and sales and marketing of products than we do. Early-stage companies may also prove to be significant competitors, particularly through
collaborative arrangements they may have with large and established companies. In addition, these third



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parties compete with us in recruiting and retaining qualified scientific and management personnel, establishing clinical trial sites and patient registration
for clinical trials, as well as in acquiring therapies and therapy licenses complementary to our programs or advantageous to our business. We expect that our ability to compete effectively will depend upon our ability to:



| |  |  | successfully and rapidly complete clinical trials and obtain all requisite regulatory approvals in a cost-effective manner;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------



| |  |  | attract and retain key personnel;
| | - |  | ---------------------------------



| |  |  | demonstrate the competitive advantages of our product candidates. For example, Aridol must prove to be convenient and effective as a test for airway inflammation
which identifies and determines the severity of asthma. In addition, Bronchitol must improve the quality of life and health of people with chronic obstructive lung diseases such as bronchiectasis, cystic fibrosis and chronic bronchitis;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | build an adequate manufacturing, sales and marketing infrastructure. We face the risk that our future manufacturing, sales and marketing infrastructure may be
inadequate for the commercialization of our products or that competitors have faster and more effective manufacturing, sales and marketing capacities;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | secure the support of key clinicians and physicians. The success of our products is dependent on the acceptance of our products by key clinicians and physicians. We
face the risk that our products may not be well received or that a product will be released by a competitor which is preferred by key clinicians and physicians; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | identify and obtain other product candidates on commercially reasonable terms which will provide us with a pipeline of potential product candidates which may reduce
the risk if any of our existing product candidates or are adversely affected.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Future sales of our products may suffer if they are not
accepted in the marketplace by physicians, patients and the medical community.

There is a risk that Aridol, Bronchitol or our other
product candidates may not gain market acceptance among physicians, patients and the medical community. The degree of market acceptance of Aridol and Bronchitol or our other product candidates will depend on a number of factors. For example, Aridol
must prove to be convenient and effective as a test for airway hyper-responsiveness which assists with the identification and severity of asthma. In addition, Bronchitol must improve the quality of life for people with chronic obstructive lung
diseases such as bronchiectasis, cystic fibrosis and chronic bronchitis. The prevalence and severity of any side effects to Aridol or Bronchitol could negatively affect market acceptance of both Aridol and Bronchitol. Failure to achieve market
acceptance of Aridol and Bronchitol would significantly harm our business.

The degree of market acceptance of any of our approved products
will depend on a variety of factors, including:



| |  |  | timing of market introduction and the number and clinical profile of competitive products. There are currently a range of existing alternative products to each of
our products and we are aware that new products are being developed;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our ability to provide acceptable evidence of safety and efficacy and our ability to secure the support of key clinicians and physicians for our products;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | relative convenience and ease of administration. In the case of Aridol and Bronchitol, there is a risk that using dry powder inhalation technology may not be well
accepted in the market place;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | cost-effectiveness compared to existing and new treatments;
| | - |  | -----------------------------------------------------------



| |  |  | availability of coverage, reimbursement and adequate payment from health maintenance organizations and other third-parties;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------



| |  |  | prevalence and severity of adverse side effects; and
| | - |  | ----------------------------------------------------



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| |  |  | other advantages over other treatment methods.
| | - |  | ----------------------------------------------

If we are unable to obtain acceptable prices or adequate reimbursement from third-parties for Aridol and Bronchitol, or any other product candidates that we may seek to commercialize, our revenues and prospects for profitability will
suffer.

The commercial success of our product candidates is substantially dependent on whether third-party coverage and reimbursement
is available from government bodies such as Medicare and Medicaid, private health insurers, including managed care organizations, and other third-parties.

Many patients will not be capable of paying for our products themselves and will rely on third-parties to pay for their medical needs. The U.S. Centers for Medicare and Medicaid Services, health maintenance
organizations and other third-parties in the U.S., the E.U., Australia and other jurisdictions are increasingly attempting to contain healthcare costs by limiting both coverage and the level of reimbursement of new products and, as a result, they
may not cover or provide adequate payment for our products. Our products may not be considered cost-effective and reimbursement may not be available to consumers or may not be sufficient to allow our products to be marketed on a competitive basis.
Large private managed care organizations, group purchasing organizations and similar organizations are exerting increasing influence on decisions regarding the use of, and reimbursement levels for, particular treatments. Such third-parties,
including Medicare, are challenging the prices charged for medical products and services, and many third-parties limit or delay reimbursement for newly approved health care products. In particular, third-parties may limit the reimbursed indications.
Cost-control initiatives could decrease the price we establish for products, which could result in product revenues lower than anticipated. If the prices for our product candidates decrease or if governmental and other third-parties do not provide
adequate coverage and reimbursement levels, our prospects for revenue and for profitability will suffer.

If there are fewer individuals in our target
markets than we estimate, we may not generate sufficient revenues to continue development of our product candidates or continue operations.

Our estimate of the patient population of our target markets is based on published studies as well as internal analyses and studies we have commissioned. If the results of these studies or our analysis do not accurately reflect the number
of patients in our target markets, our assessment of the market may be wrong, making it difficult or impossible for us to meet our revenue goals. In addition, it is difficult to determine the portion of the patient population that might use Aridol
and/or Bronchitol, or our other product candidates.

Our orphan drug exclusivity for Bronchitol may not provide us with a competitive advantage.

The FDA has granted Orphan Drug designation to Bronchitol for the treatment of both bronchiectasis and CF for patients at risk of
developing bronchiectasis. Orphan drug designation for Bronchitol for the treatment of both bronchiectasis and cystic fibrosis for patients at risk of developing bronchiectasis is an important element of our competitive strategy. Any company that
obtains the first FDA approval for a designated orphan drug for a rare disease generally receives marketing exclusivity for use of that drug for the designated condition for a period of seven years from approval. However, the FDA may permit other
companies to market a form of mannitol, the active ingredient in Bronchitol, not covered by our patent, to treat bronchiectasis and cystic fibrosis for patients at risk of developing bronchiectasis if any such product demonstrates clinical
superiority, or if we are unable to provide sufficient drug supply to meet medical needs. More than one product may also be approved by the FDA for the same orphan indication or disease as long as the products are different drugs. Any of these FDA
actions could create a more competitive market for us. Additionally, our orphan drug exclusivity for Bronchitol does not apply to other drugs to treat bronchiectasis or cystic fibrosis for patients at risk of developing bronchiectasis that do not
contain mannitol, or to drugs containing mannitol that seek approval for uses other than bronchiectasis or cystic fibrosis for patients at risk of developing bronchiectasis.

The European Medicines Agency has likewise granted Orphan Drug designation for Bronchitol in the treatment of cystic fibrosis. European orphan drug
designation provides comparable benefits to those granted in the U.S. but likewise, there are risks and limitations associated with orphan drug designation in Europe. Our orphan drug exclusivity may thus not ultimately provide us a true competitive
advantage, and our business could suffer as a result.



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Risks Relating to Regulatory Issues

Our products are subject to extensive regulation, which can be costly and time-consuming, and we may not obtain approvals for the commercialization of some or all of our products.

The clinical development, manufacturing, sales and marketing of our products are subject to extensive regulation by regulatory authorities in the U.S.,
the E.U., Australia and elsewhere. These regulations vary in important, meaningful ways from country to country.

We are not permitted to
market a potential drug in the U.S. until we receive approval of a New Drug Application, or NDA, from the FDA. We have not yet received an NDA approval from the FDA for any of our products. Obtaining an NDA approval is expensive and is a complex,
lengthy and uncertain process. The FDA approval process for a new drug involves completion of preclinical studies and the submission of the results of these studies to the FDA, together with proposed clinical protocols, manufacturing information,
analytical data and other information in an investigational new drug application or IND, which must become effective before human clinical trials may begin. Clinical development typically involves three phases of study: Phase I, II and III. The most
significant costs associated with clinical development are the Phase III clinical trials as they tend to be the longest and largest studies conducted during the drug development process. After completion of clinical trials, an NDA may be submitted
to the FDA. In responding to an NDA, the FDA may refuse to file the application, or if accepted for filing, the FDA may grant marketing approval, request additional information or deny the application if it determines that the application does not
provide an adequate basis for approval. In addition, failure to comply with FDA and other applicable foreign and U.S. regulatory requirements may subject us to administrative or judicially imposed sanctions. The FDA has accepted an IND for Aridol
and for Bronchitol. We have completed two Phase III clinical trials of Aridol to support a U.S. registration of Aridol. Clinical trials of our other product candidates, including Bronchitol and PXS25/64, will continue for several years, but may take
significantly longer to complete. We have completed a Phase II and a Phase III clinical trial of Bronchitol for the treatment of bronchiectasis outside of the U.S. and are preparing for an additional Phase III clinical trial of Bronchitol for
bronchiectasis in the U.S. We have also completed a Phase II clinical trial of Bronchitol for the treatment of cystic fibrosis, have an additional Phase II dose ranging clinical trial and a Phase III clinical trial in progress outside of the U.S.,
and are preparing for an additional Phase III clinical trial of Bronchitol for cystic fibrosis in the U.S. Our other product candidates, including PXS25/64 are currently in varying stages of the research or preclinical phase of development.

Despite the substantial time and expense invested in preparation and submission of an NDA or equivalents in other jurisdictions,
regulatory approval is never guaranteed. The FDA and other regulatory authorities in the U.S., the E.U., Australia and elsewhere, exercise substantial discretion in the drug approval process. The number, size and design of preclinical studies and
clinical trials that will be required will vary depending on the product, the disease or condition for which the product is intended to be used and the regulations and guidance documents applicable to any particular product. The FDA or other
regulators can delay, limit or deny approval of a product for many reasons, including, but not limited to, the fact that regulators may not approve our, or our third-party, manufacturing processes or facilities or that new laws may be enacted or
regulators may change their approval policies or adopt new regulations requiring new or different evidence of safety and efficacy for the intended use of a product.

Even if our product candidates receive regulatory approval, we may still face development and regulatory difficulties that may delay or impair future sales of our products and we would be subject to ongoing
regulatory obligations and restrictions, which may result in significant expense and limit our ability to commercialize our product candidates.

Even with regulatory approval to sell Aridol or any other product candidate, the relevant regulatory authorities may, nevertheless, impose significant restrictions on the indicated uses, manufacturing, labeling, packaging, storage,
advertising, promotion and record keeping or impose ongoing requirements for post-approval studies and adverse event reporting. In addition, regulatory agencies subject a marketed product, its manufacturer and the manufacturers facilities to
continual review and periodic inspections. Potentially costly follow-up or post-marketing clinical studies may be required as a condition of approval to further substantiate safety or efficacy, or to investigate specific issues of interest to the
regulatory authority. Previously unknown problems with the product candidate, including adverse events of unanticipated severity or frequency, may result in restrictions on the marketing of the product, and could include withdrawal of the product
from the market. If we discover previously unknown problems with a product or our manufacturing facilities or the manufacturing facilities of a contract



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manufacturer, a regulatory agency may impose restrictions on that product, on us or on our third-party contract manufacturers, including requiring us to
withdraw the product from the market. If we fail to comply with applicable regulatory requirements, a regulatory agency may:



| |  |  | issue warning letters;
| | - |  | ----------------------



| |  |  | impose civil or criminal penalties;
| | - |  | -----------------------------------



| |  |  | suspend our regulatory approval;
| | - |  | --------------------------------



| |  |  | suspend any of our ongoing clinical trials;
| | - |  | -------------------------------------------



| |  |  | refuse to approve pending applications or supplements to approved applications filed by us;
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | impose restrictions on our operations, including closing our contract manufacturers facilities or terminating licenses to manufacture Good Manufacturing
Practice grade material; or
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | seize or detain products or require a product recall.
| | - |  | -----------------------------------------------------

Any of the foregoing could seriously harm the commercialization of our products and our results and operations may be seriously harmed. Likewise, any failure to comply with ongoing regulatory requirements may
significantly and adversely affect our ability to commercialize our product.

In addition, the law or regulatory policies governing pharmaceuticals may
change. New statutory requirements may be enacted or additional regulations may be enacted that could prevent or delay regulatory approval of our products. We cannot predict the likelihood, nature or extent of adverse government regulation that may
arise from future legislation or administrative action. If we are not able to maintain regulatory compliance, we might not be permitted to market our products and our business could suffer.

Risks Relating to Product Liability Claims

If product
liability lawsuits are successfully brought against us, we will incur substantial liabilities and damage to our reputation and may be required to limit commercialization of Aridol and Bronchitol or other product candidates.

We face product liability exposure related to the testing of our product candidates in human clinical trials. We are currently conducting continuing
clinical trials in respect of Aridol as well as clinical trials of Bronchitol and we expect to commence clinical trials of PXS25/64. We have commenced initial commercial sales of Aridol in Australia and Europe. We may face exposure to product
liability claims in relation to Aridol and other products which we commercially market and sell in the future by a significantly greater number of persons than were involved in the clinical trials.

Regardless of merit or eventual outcome, liability claims may result in:



| |  |  | decreased demand for our products and product candidates;
| | - |  | ---------------------------------------------------------



| |  |  | injury to our reputation;
| | - |  | -------------------------



| |  |  | withdrawal of clinical trial participants;
| | - |  | ------------------------------------------



| |  |  | costs of related litigation;
| | - |  | ----------------------------



| |  |  | substantial monetary awards to patients and others;
| | - |  | ---------------------------------------------------



| |  |  | loss of revenues; and
| | - |  | ---------------------



| |  |  | the inability to commercialize our products and product candidates.
| | - |  | -------------------------------------------------------------------

With respect to our clinical trials, we enter into indemnity agreements in favor of the hospitals, institutions, authorities, clinicians and investigators who are involved in the clinical trials on our behalf. The
majority of the indemnities are in a substantially similar form and where possible are based on industry standard indemnities in the



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countries in which we undertake clinical trials. Certain of the agreements have been negotiated on a case by case basis and vary from the standard. The
standard indemnities typically provide that we will indemnify in respect of all claims and proceedings made by any of the patients or non-patient volunteers participating in the relevant clinical trials for personal injury arising from the
administration of the product under investigation or any clinical intervention or procedure required.

We have liability insurance that
covers our clinical trials in countries where we conduct clinical trials. We have expanded our insurance coverage to include the sale of Aridol and will expand insurance coverage in the future for any product candidates which are granted regulatory
marketing authorization. Having regard to the good safety profile of Aridol and Bronchitol, the varied use of mannitol in humans, the number of clinical trials undertaken to date without a material claim being made against us, we consider that our
liability insurance is reasonable for our current activities. However, insurance coverage is increasingly expensive. We may not be able to maintain insurance coverage at a reasonable cost and we may not be able to obtain insurance coverage that we
consider reasonable or that will be adequate to satisfy any liability that may arise and the claim for damages could be substantial. If we are not able to obtain adequate coverage at a reasonable cost, the commercialization of our products may be
delayed or severely compromised.

If there is a claim made against us or some other problem that is attributable to our products or product
candidates, our ordinary share and ADS prices may be negatively affected. Even if we were ultimately successful in product liability litigation, the litigation would consume substantial amounts of our financial and managerial resources and may
create adverse publicity, all of which would impair our ability to generate sales of the product the subject of the litigation as well as our other potential products.

Risks Relating to Intellectual Property and License Arrangements

Aridol and Bronchitol are based in part
on intellectual property rights we license from others, and any termination of those licenses could seriously harm our business as the loss of any rights to market key products would seriously harm our operating results.

We have an exclusive worldwide license from Sydney South West Area Health Service to develop and commercialize certain intellectual property relating to
the use of mannitol, the component part of both Aridol and Bronchitol, to induce sputum and promote airway clearance and also in the use as a test of airway function and susceptibility to asthma. We also have an exclusive license from ANU
Enterprises Pty Ltd to develop and commercialize intellectual property relating to the treatment of inflammatory or immune-mediated conditions in patients by administering a phosphosugar. Both of these license agreements impose payment and other
material obligations on us. If our agreement with Sydney South West Area Health Service were terminated, then we would have no further rights to develop and commercialize Aridol and Bronchitol which would seriously harm our business.

Third parties may own or control patents or patent applications that we may be required to license to commercialize our product candidates, that we may infringe, or
that could result in litigation that would be costly and time consuming.

Our ability to commercialize Aridol and Bronchitol and our
other product candidates depends upon our ability to develop, manufacture, market and sell these products without infringing the proprietary rights of third parties. A number of pharmaceutical and biotechnology companies, universities and research
institutions have or may be granted patents that cover technologies similar to the technologies owned by or licensed to us. We may choose to seek, or be required to seek, licenses under third-party patents, which would likely require the payment of
license fees or royalties or both. A license may not be available to us on commercially reasonable terms, or at all. We may also be unaware of existing patents or other proprietary rights of third parties that may be infringed by Aridol and
Bronchitol or our other product candidates. As patent applications can take many years to issue, there may be other currently pending applications which may later result in issued patents that are infringed by Aridol and Bronchitol or our other
product candidates.

There has been substantial litigation and other proceedings regarding patent and other intellectual property rights in
the pharmaceutical and biotechnology industries. Defending ourselves against third-party claims, including litigation in particular, would be costly and time consuming and would divert managements attention from our



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business, which could lead to delays in our development or commercialization efforts. If third parties are successful in their claims, we might have to pay
substantial damages or take other actions that are adverse to our business. As a result of intellectual property infringement claims, or to avoid potential claims, we might be:



| |  |  | prohibited from selling or licensing any product candidate that we may develop unless the patent holder licenses the patent to us, which it is not required to do;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | required to expend considerable amounts of money in defending the claim;
| | - |  | ------------------------------------------------------------------------



| |  |  | required to pay substantial royalties or grant a cross license to our patents to another patent holder;
| | - |  | -------------------------------------------------------------------------------------------------------



| |  |  | required to pay substantial monetary damages; or
| | - |  | ------------------------------------------------



| |  |  | required to redesign the formulation of a product so it does not infringe, which may not be possible or could require substantial funds and time.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------

We may also be forced to bring an infringement action if we believe that a third party is infringing our protected
intellectual property. Any such litigation will be costly, time consuming and divert managements attention, and the outcome of any such litigation may not be favorable to us.

Our intellectual property rights may not preclude competitors from developing competing products and our business may suffer.

If we are not able to protect our proprietary technology, trade secrets and know-how, our competitors may use our intellectual property to develop competing products. Our patents, including our licensed patents
relating to the use and manufacture of Aridol and Bronchitol, may not be sufficient to prevent others from competing with us or using similar technologies. Most of our patents covering Aridol and Bronchitol expire in 2015. Therefore, we will not be
able to depend on these patents past these relevant dates to exclude competitors from developing generic versions of Aridol and Bronchitol. Our issued patents and those that we may issue in the future, or those licensed to us, may be challenged,
invalidated or circumvented, which could limit our ability to stop competitors from marketing related products or the term of patent protection that we may have for our product candidates. The occurrence of any of the foregoing events could harm our
competitive position and seriously harm our business.

Our trade secrets relating to our product candidates and the manufacture of our
product candidates may become known or independently discovered or competitors may develop alternatives. We disclose confidential information and trade secrets from time to time provided that the recipient executes a non-disclosure agreement or
otherwise owes us obligations of confidentiality. Confidentiality agreements may be breached and we may have no effective remedy for such a breach. Enforcing a claim that a third party illegally obtained and is using our trade secrets is expensive
and time consuming, and the outcome is unpredictable. Failure to obtain or maintain confidential information and trade secret protection could adversely affect our competitive business position.

If we fail to enforce adequately or defend our intellectual property rights our business may be harmed.

Our commercial success depends, to a large extent, on obtaining and maintaining patent and trade secret protection for our products, the methods used to
manufacture those products and the methods for treating patients using those products. A key tool in protecting our products and our technologies from unauthorized use by third parties is the extent that valid and enforceable patents or trade
secrets cover them. Our ability to obtain patents is uncertain and there is a risk that we may not be able to secure and maintain patents which we require to defend our intellectual property position. Patents provide only limited protections and may
not adequately protect our rights or permit us to gain or keep any competitive advantage. Some countries in which we may sell our product candidates or license our intellectual property may fail to protect our intellectual property rights to the
same extent as the protection that may be afforded in the U.S. or Australia. Some legal principles remain unresolved and there has not been a consistent policy regarding the breadth or interpretation of claims allowed in patents in the U.S., the
E.U., Australia or elsewhere. In addition, the specific content of patents and patent applications that are necessary to support and interpret patent claims is highly uncertain due to the complex nature of the relevant legal, scientific and factual
issues. Changes in either patent laws or in interpretations of patent laws in the U.S., the E.U. or elsewhere may diminish the value of our intellectual property or narrow the scope of our patent protection.



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Even if patents are issued, those patents can be challenged by our competitors who can argue such patents
are invalid. Patents also will not protect our products if competitors devise ways of making these product candidates without legally infringing our patents. The U.S. Federal Food, Drug and Cosmetic Act and FDA regulations and policies and
equivalents in other jurisdictions provide incentives to manufacturers to challenge patent validity or create modified, noninfringing versions of a drug in order to facilitate the approval of abbreviated new drug applications for generic
substitutes.

Proprietary trade secrets and unpatented know-how are also very important to our business. We rely on trade secrets to
protect our technology, especially where we do not believe that patent protection is appropriate or obtainable. However, trade secrets are difficult to protect. Our employees, consultants, contractors, outside scientific collaborators and other
advisors may unintentionally or willfully disclose our confidential information to competitors, and confidentiality agreements may not provide an adequate remedy in the event of unauthorized disclosure of confidential information. Enforcing a claim
that a third party illegally obtained and is using our trade secrets is expensive and time consuming, and the outcome is unpredictable. Failure to obtain or maintain trade secret protection could adversely affect our competitive business position.
To date, we are not aware of any unintentional or willful disclosure of any of our material confidential information or any unauthorized use of our confidential information and we have not been required to seek remedy for any such unauthorized
disclosure or use.

Risks Relating to Resources

If we fail to attract and keep senior management and key scientific personnel, we may be unable to successfully develop and commercialize our product candidates.

Our success depends on our continued ability to attract, retain and motivate highly qualified management, clinical and scientific personnel,
manufacturing personnel, sales and marketing personnel and on our ability to develop and maintain important relationships with clinicians, scientists and leading academic and health institutions, including in particular the Sydney South West Area
Health Service.

The loss of services of one or more of our members of key management could delay or compromise the successful completion
of our clinical trials or the commercialization of Aridol and Bronchitol and our other product candidates. We enter into employment agreements with each of our employees, including each member of our key management. Each of our employees agree to a
specific period of notice that they or we must give in order to terminate their employment. Employees can terminate their employment by giving between one to three months notice (as set out in the relevant employees employment agreement).

In the near term we will need to continue to attract and retain manufacturing personnel and sales and marketing personnel and effectively
integrate them into our organization to coincide with the expected growth of commercial sales of Aridol in Australia, Europe and in other jurisdictions. If we fail to attract or effectively integrate new personnel and consultants into our
organization and create effective working relationships among them and other members of management, the future development and commercialization of Aridol and our other product candidates may suffer, harming future regulatory approvals, sales of our
products and our results of operations.

There is significant competition from other companies and research and academic institutions for
qualified personnel in the areas of our activities. If we fail to identify, attract, retain and motivate these highly skilled personnel, we may be unable to continue our development and commercialization activities.

The addition of new employees and the loss of key employees, particularly in key positions, can be disruptive and may also cause the future development
and commercialization of our product candidates to suffer, harming future regulatory approvals, sales of our products and our results of operations.

We do not currently carry key person insurance on the lives of members of senior management. We consider that at this stage of our development it is reasonable not to carry any key person insurance.

We will need to significantly increase the size of our organization, and we may experience difficulties in managing growth.

We are currently a small company with 68 employees and full time contractors as of June 30, 2007. In order to continue our clinical trials and
commercialize our product candidates, manufacture commercial quantities of



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our products and market and sell products, we will need to increase our operations, including expanding our employee base. Our future financial performance
and our ability to commercialize our products and to compete effectively will depend, in part, on our ability to manage any future growth effectively. To that end, we must be able to:



| |  |  | manage our preclinical studies and clinical trials effectively;
| | - |  | ---------------------------------------------------------------



| |  |  | undertake and manage the manufacturing of product effectively;
| | - |  | --------------------------------------------------------------



| |  |  | undertake and manage sales and marketing effectively;
| | - |  | -----------------------------------------------------



| |  |  | integrate current and additional management, administrative, financial and sales and marketing personnel;
| | - |  | ---------------------------------------------------------------------------------------------------------



| |  |  | develop our administrative, accounting and management information systems and controls; and
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | hire and train additional qualified personnel.
| | - |  | ----------------------------------------------

The acquisition or licensing of other products or product candidates may put a strain on our operations and will likely require us to seek additional financing.

One of our strategies is to develop and license or acquire complementary products or product candidates. We have no present agreement regarding any new
material licensing or acquisitions. However, if we do undertake any licensing or acquisitions, the process of undertaking the licensing or acquisitions and integrating a licensed or acquired product or product candidate into our business may put a
strain on our operations, including diversion of personnel and financial resources and diversion of managements attention. In addition, any acquisition would give rise to potentially significant additional operating costs which would likely
require us to seek additional financing. Future acquisitions could result in additional issuances of equity securities that would dilute the ownership of existing shareholders and holders of our ADSs. Future acquisitions could also result in us
incurring debt, contingent liabilities or the amortization of expenses related to other intangible assets, any of which could adversely affect our operating results.

Risks Relating to Takeovers

Our constitution may discourage attempts by shareholders to make a
proportional takeover for us and could restrict the ability for shareholders to obtain a premium from such a transaction.

Provisions
of our constitution contain a proportional takeover provision which provides that if a person makes a proportional takeover offer for less than all of the share capital in us, shareholders are entitled to vote to determine whether the proportional
takeover offer may proceed. A person may wish to make a proportional takeover offer for a number of reasons, including, if they wish to increase their control of us and/or influence the composition of the board of directors. Arguably, the
proportional takeover provisions in our constitution make it more difficult to achieve a proportional takeover and therefore may discourage proportional takeover offers and make it more difficult for a person to gain proportional control of us and
could restrict the ability for shareholders to obtain a premium from such a transaction. The proportional takeover provisions in our constitution terminate and must be renewed every three years. At our annual general meeting of shareholders held on
26 October 2006, our shareholders approved the extension of the proportional takeover provision for a further three years.

Australian takeovers
laws may discourage takeover offers being made for us or may discourage the acquisition of large numbers of our shares.

We are
incorporated in Australia and are subject to the takeovers laws of Australia. Among other things, we are subject to the Corporations Act 2001 (Commonwealth of Australia), or Corporations Act. Subject to a range of exceptions, the Corporations Act
prohibits the acquisition of a direct or indirect interest in our issued voting shares (including through the acquisition of ADSs) if the acquisition of that interest will lead to a persons or someone elses voting power in us increasing
from 20% or below to more than 20%, or increasing from a starting point that is above 20% and below 90%. Exceptions to the general prohibition include circumstances where the person makes a formal takeover bid for us, if the person obtains
shareholder approval for the acquisition or if the person acquires less than 3% of the voting power of us in any rolling six month period. Australian takeovers laws may discourage



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takeover offers being made for us or may discourage the acquisition of large numbers of our shares. This may have the ancillary effect of entrenching our
board of directors and may deprive or limit strategic opportunities of our shareholders and ADS holders to sell their shares and may restrict the ability of our shareholders and ADS holders to obtain a premium from such transactions. See
Item 10B - Change of Control.

Risks Related to our ADSs or Ordinary Shares

The price of our ordinary shares is highly volatile and could decline significantly.

The market price of our ordinary shares historically has been, and we expect will continue to be, subject to significant fluctuations over short periods of time. These fluctuations may be due to factors specific to
us, to changes in analysts recommendations and earnings estimates, to arbitrage between our Australian quoted shares and our ADSs, to changes in exchange rates, or to factors affecting the biopharmaceutical industry or the securities markets
in general. For example, from the initial quotation of our ordinary shares on the Australian Securities Exchange on November 10, 2003 until November 9, 2007, the closing price per share of our ordinary shares ranged from a low of A$0.34 on
November 27, 2003 to a high of A$4.53 on November 1, 2007. We may experience a material decline in the market price of our shares, regardless of our operating performance. Therefore, a holder of our ordinary shares or ADSs may not be able
to sell those ordinary shares or ADSs at or above the price paid by such holder for such shares or ADSs. Price declines in our ordinary shares or ADSs could result from a variety of factors, including many outside our control. These factors include:



| |  |  | adverse or inconclusive results or delays in our clinical trial programs;
| | - |  | -------------------------------------------------------------------------



| |  |  | unforeseen safety issues or adverse side effects resulting from the clinical trials or the commercial use of any of our products;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------



| |  |  | regulatory actions in respect of any of our products or the products of any of our competitors;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | failure of any of our products, such as Aridol, of any of our product candidates, such as Bronchitol (if approved), to achieve commercial success;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | announcements of the introduction of new products by us or our competitors;
| | - |  | ---------------------------------------------------------------------------



| |  |  | market conditions, including market conditions in the pharmaceutical and biotechnology sectors;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | increases in our costs or decreases in our revenues due to unfavorable movements in foreign currency exchange rates;
| | - |  | --------------------------------------------------------------------------------------------------------------------



| |  |  | developments or litigation concerning patents, licenses and other intellectual property rights;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | litigation or public concern about the safety of our potential products;
| | - |  | ------------------------------------------------------------------------



| |  |  | changes in recommendations or earnings estimates by securities analysts;
| | - |  | ------------------------------------------------------------------------



| |  |  | actual and anticipated fluctuations in our quarterly operating results;
| | - |  | -----------------------------------------------------------------------



| |  |  | deviations in our operating results from the estimates of securities analysts;
| | - |  | ------------------------------------------------------------------------------



| |  |  | rumors relating to us or our competitors;
| | - |  | -----------------------------------------



| |  |  | additions or departures of key personnel;
| | - |  | -----------------------------------------



| |  |  | changes in third-party reimbursement policies; and
| | - |  | --------------------------------------------------



| |  |  | developments concerning current or future strategic alliances or acquisitions.
| | - |  | ------------------------------------------------------------------------------

Class action litigation has been brought in the past against companies which have experienced volatility in the market price of their securities. We may
become involved in this type of litigation in the future. Litigation of this type is often extremely expensive and diverts managements attention and companys resources.



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In addition, since the initial listing of our ADSs on Nasdaq Global Market trading volume in our ADSs has
been limited and a significant portion of the ownership of our ADSs is concentrated with a small number of holders. The limited trading volume may adversely affect the prices at which the ADSs may be bought or sold. There can be no assurance that a
more active trading market in our ADSs will develop in the U.S.

Rights as a holder of ordinary shares are governed by Australian law and our
Constitution and differ from the rights of shareholders under U.S. law. Holders of our ordinary shares or ADSs may have difficulty in effecting service of process in the U.S. or enforcing judgments obtained in the U.S.

We are a public company incorporated under the laws of Australia. Therefore, the rights of holders of our ordinary shares are governed by Australian law
and our Constitution. These rights differ from the typical rights of shareholders in U.S. corporations. The rights of holders of ADSs are affected by Australian law and our Constitution but are governed by U.S. law. Circumstances that under U.S. law
may entitle a shareholder in a U.S. company to claim damages may also give rise to a cause of action under Australian law entitling a shareholder in an Australian company to claim damages. However, this will not always be the case.

Holders of our ordinary shares or ADSs may have difficulties enforcing, in actions brought in courts in jurisdictions located outside the U.S.,
liabilities under U.S. securities laws. In particular, if such a holder sought to bring proceedings in Australia based on U.S. securities laws, the Australian court might consider:



| |  |  | that it did not have jurisdiction; and/or
| | - |  | -----------------------------------------



| |  |  | that it was not an appropriate forum for such proceedings; and/or
| | - |  | -----------------------------------------------------------------



| |  |  | that, applying Australian conflict of laws rule, U.S. law (including U.S. securities laws) did not apply to the relationship between holders of our ordinary shares
or ADSs and us or our directors and officers; and/or
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | that the U.S. securities laws were of a public or penal nature and should not be enforced by the Australian court.
| | - |  | ------------------------------------------------------------------------------------------------------------------

All but one of our directors and executive officers are residents of countries other than the U.S. Furthermore, all or a substantial portion of their
assets and our assets are located outside the U.S. As a result, it may be very difficult or may not be possible for a holder of our ordinary shares or ADSs to:



| |  |  | effect service of process within the U.S. upon any of our directors and executive officers or on us;
| | - |  | ----------------------------------------------------------------------------------------------------



| |  |  | enforce in U.S. courts judgments obtained against any of our directors and executive officers or us in the U.S. courts in any action, including actions under the
civil liability provisions of U.S. securities laws;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | enforce in U.S. courts judgments obtained against any of our directors and senior management or us in courts of jurisdictions outside the United States in any
action, including actions under the civil liability provisions of U.S. securities laws; or
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | bring an original action in an Australian court to enforce liabilities against any of our directors and executive officers or us based upon U.S. securities laws.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------

Holders of our ordinary shares and ADSs may also have difficulties enforcing in courts outside the U.S. judgments
obtained in the U.S. courts against any of our directors and executive officers or us, including actions under the civil liability provisions of the U.S. securities laws.

Shares or ADSs eligible for public sale could adversely affect the price of our ordinary shares.

The market price for our shares or ADSs could decline as a result of sales by our existing shareholders or management of ordinary shares or the perceptions that these sales could occur. These sales may also make it difficult for us to sell
equity securities in the future at a time and at a price when we deem appropriate.



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Currency fluctuations may adversely affect the price of the ADSs relative to the price of our ordinary shares.

The price of our ordinary shares is quoted in Australian dollars and the price of our ADSs is quoted in U.S. dollars. Movements in the
Australian dollar/U.S. dollar exchange rate may adversely affect the U.S. dollar price of our ADSs and the U.S. dollar equivalent of the price of our ordinary shares. The exchange rates between the Australian dollar and the U.S. dollar have
fluctuated. If the value of the Australian dollar appreciates against the U.S. dollar, this may positively affect the U.S. dollar price of our ADSs and the U.S. dollar equivalent of the price of our ordinary shares, even if the price of our ordinary
shares in Australian dollars increases or remains unchanged. However, if the Australian dollar weakens against the U.S. dollar, the U.S. dollar price of the ADSs could decline, even if the price of our ordinary shares in Australian dollars increases
or remains unchanged. If dividends are payable, we will likely calculate and pay any cash dividends in Australian dollars and, as a result, exchange rate movements will affect the U.S. dollar amount of any dividends holders of our ADSs will receive
from the depositary (as defined below in Description of American Depositary Shares). The potential impact that currency fluctuations may have on our earnings is set out in the risk factor Risks Related to Our Business 
Currency fluctuations may expose us to increased costs and revenue decreases.

We may become a passive foreign investment company, or a PFIC, for
U.S. federal income tax purposes, which could result in negative tax consequences to the holders of our ordinary shares or ADSs.

Based
on an analysis of our assets and gross income, we believe that we may be a PFIC for our current tax year, that we have not been a PFIC for our tax year ended June 30, 2007, and that we have been a PFIC for our tax years ended June 30,
2006, June 30, 2005 and June 30, 2004. We have not conducted a PFIC analysis for any tax year prior to our tax year ended June 30, 2004. The determination of whether we are, or at any time in the past have been, a PFIC is made
annually on a taxable year basis and depends on factors such as the composition of our income and the value of our assets. If we are classified as a PFIC in any taxable year that a U.S. Holder (as defined in the section entitled
Taxation) owns our ordinary shares or ADSs, we generally will continue to be treated as a PFIC for that U.S. Holder in all succeeding years. Such U.S. Holder would be subject to additional taxes on any excess distributions
received from us and any gain realized from the sale or other disposition of our ordinary shares or ADSs. We urge U.S. investors to consult their own tax advisors about the application of the PFIC rules and certain elections that may help to
minimize adverse U.S. federal income tax consequences in their particular circumstances. For a further discussion of the U.S. federal income tax consequences of investing in a PFIC, see the discussion below under the section entitled Item 10D -
Taxation.

We have never paid a dividend and we do not intend to pay dividends in the foreseeable future which means that holders of shares
and ADSs may not receive any return on their investment from dividends.

To date, we have not declared or paid any cash dividends on
our ordinary shares and currently intend to retain any future earnings for funding growth. We do not anticipate paying any dividends in the foreseeable future. Dividends may only be paid out of our profits. Payment of cash dividends, if any, in the
future will be at the discretion of our board of directors or, if our directors do not exercise their power to issue dividends, our shareholders in a general meeting may. Our holders of shares and ADSs may not receive any return on their investment
from dividends.

Our ADR holders are not shareholders and do not have shareholder rights.

The Bank of New York, as depositary, executes and delivers our American Depositary Receipts, or ADRs, on our behalf. Each ADR is a certificate evidencing
a specific number of American Depositary Shares, also referred to as ADSs. Our ADR holders will not be treated as shareholders and do not have the rights of shareholders. The depositary will be the holder of the shares underlying our ADRs.
Holders of our ADRs will have ADR holder rights. A deposit agreement among us, the depositary and our ADR holders, and the beneficial owners of ADRs, sets out ADR holder rights as well as the rights and obligations of the depositary. New York law
governs the deposit agreement and the ADRs.

Our ADR holders do not have the same voting rights as our shareholders. Shareholders are
entitled to our notices of general meetings and to attend and vote at our general meetings of shareholders. At a general meeting, every shareholder present (in person or by proxy, attorney or representative) and entitled to vote has one vote on a
show of hands. Every shareholder present (in person or by proxy, attorney or representative) and entitled to vote has one vote per fully paid ordinary share on a poll. This is subject to any other rights or restrictions which may be



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attached to any shares. Our ADR holders may instruct the depositary to vote the ordinary shares underlying their ADRs, but only if we ask the depositary to
ask for their instructions. If we do not ask the depositary to ask for the instructions, our ADR holders are not entitled to receive our notices of general meeting or instruct the depositary how to vote. Our ADR holders will not be entitled to
attend and vote at a general meeting unless they withdraw the ordinary shares. However, our ADR holders may not know about the meeting enough in advance to withdraw the shares. If we ask for our ADR holders instructions, the depositary will
notify our ADR holders of the upcoming vote and arrange to deliver our voting materials and form of notice to them. The depositary will try, as far as practical, subject to Australian law and the provisions of the depositary agreement, to vote the
shares as our ADR holders instruct. The depositary will not vote or attempt to exercise the right to vote other than in accordance with the instructions of the ADR holders. We cannot assure our ADR holders that they will receive the voting materials
in time to ensure that they can instruct the depositary to vote their shares. In addition, there may be other circumstances in which our ADR holders may not be able to exercise voting rights.

Our ADR holders do not have the same rights to receive dividends or other distributions as our shareholders. Subject to any special rights or
restrictions attached to a share, the directors may determine that a dividend will be payable on a share and fix the amount, the time for payment and the method for payment (although we have never declared or paid any cash dividends on our ordinary
stock and we do not anticipate paying any cash dividends in the foreseeable future). Dividends may be paid on shares of one class but not another and at different rates for different classes. Dividends and other distributions payable to our
shareholders with respect to our ordinary shares generally will be payable directly to them. Any dividends or distributions payable with respect to ordinary shares will be paid to the depositary, which has agreed to pay to our ADR holders the cash
dividends or other distributions it or the custodian receives on shares or other deposited securities, after deducting its fees and expenses. Our ADR holders will receive these distributions in proportion to the number of shares their ADSs
represent. In addition, there may be certain circumstances in which the depositary may not pay to our ADR holders amounts distributed by us as a dividend or distribution.

There are circumstances where it may be unlawful or impractical to make distributions to the holders of our ADRs.

The deposit agreement with the depositary allows the depositary to distribute the foreign currency only to those ADR holders to whom it is possible to do so. If a distribution is payable by us in Australian dollars,
the depositary will hold the foreign currency it cannot convert for the account of the ADR holders who have not been paid. It will not invest the foreign currency and it will not be liable for any interest. If the exchange rates fluctuate during a
time when the depositary cannot convert the foreign currency, our ADR holders may lose some of the value of the distribution.

The
depositary is not responsible if it decides that it is unlawful or impractical to make a distribution available to any ADR holders. This means that our ADR holders may not receive the distributions we make on our shares or any value for them if it
is illegal or impractical for us or the depositary to make them available to them.

We will be exposed to risks relating to evaluations of controls
required by the Sarbanes-Oxley Act.

Changing laws, regulations and standards relating to corporate governance and public disclosure,
including the Sarbanes-Oxley Act of 2002 (Sarbanes-Oxley Act) and related regulations implemented by the SEC, have substantially increased legal and financial compliance costs. We expect that our efforts to comply with applicable laws
and regulations, including the Sarbanes-Oxley Act, will involve significant, and potentially increasing, costs. In particular, we will be evaluating our internal controls systems to allow management to report on, and our independent auditors to
attest to, our internal controls. We will be performing the system and process evaluation and testing (and any necessary remediation) required to comply with the management certification and auditor attestation requirements of Sarbanes-Oxley Act. We
cannot be certain as to the timing of completion of our evaluation, testing and remediation actions or the impact of the same on our operations. If we are not able to implement the requirements of the Sarbanes-Oxley Act in a timely manner or
adequately, we may be subject to sanctions or investigation by regulatory authorities, including the SEC. Any action of this type could adversely affect our financial results, investors confidence in our company and our ability to access
capital markets, and could cause our share price and the price of our ADSs to decline.



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|ITEM 4. | INFORMATION ON THE COMPANY
|------- | --------------------------



|A. | History and Development of the Company
|-- | --------------------------------------

Pharmaxis
Ltd is a public company limited by shares which is domiciled in Australia and operates under, and is subject to, Australian law.

The
Company was incorporated on May 29, 1998 in the Australian Capital Territory, Australia under the name Praxis Pharmaceuticals Australia Pty Ltd. On June 6, 2002, the Company changed its name from Praxis
Pharmaceuticals Australia Pty Ltd to Pharmaxis Pty Ltd. On September 5, 2003, the Company changed its name from Pharmaxis Pty Ltd to Pharmaxis Ltd to reflect the change of company type from a
proprietary company limited by shares to a public company limited by shares undertaken at that time. The Companys ordinary shares are quoted on the Australian Securities Exchange and our American Depositary Shares (ADS) are
quoted on the Nasdaq Global Market. Each ADS represents 15 ordinary shares. In November, 2005 we completed a public offering of 1.3 million ADSs and a placement of 19.9 million ordinary shares and received A$ 79.4 million therefrom
after payment of underwriting fees and offering expenses.

Our principal place of business is Unit 2, 10 Rodborough Road, Frenchs Forest,
NSW 2086, Australia, and the Companys telephone number is 011 61 2 9454 7200.



|B. | Business Overview
|-- | -----------------

We are an Australian specialty
integrated pharmaceutical company focused on the development of new products for the diagnosis and treatment of chronic respiratory and immune disorders. We have developed Aridol, as a novel tool for the diagnosis of asthma and management of asthma
and chronic obstructive pulmonary disease, or COPD. The Aridol test mimics the bronchoconstriction that occurs in inflamed airways during asthma episodes and may be used to assist with the identification of people who have airway
hyperresponsiveness, a hallmark of untreated or poorly controlled asthma. Aridol may also be used to determine the appropriate doses of anti-inflammatory medicine such as inhaled corticosteroids. We received marketing approval in Australia in March
2006 and commenced commercial supply of Aridol in Australia in June 2006. In October 2006 we obtained marketing approval in Sweden, as part of our entry to the remainder of the European Union, or the E.U., through the mutual recognition procedure.
In June 2007 we successfully completed the E.U. mutual recognition procedure which permitted marketing approvals of Aridol by Germany, France, the United Kingdom, Italy, the Netherlands, Belgium, Denmark, Greece, Spain, Finland, Ireland, Norway and
Portugal. In August 2006 we completed a pivotal U.S. Phase III clinical trial to determine the selectivity and specificity of Aridol as a test for the detection of airway inflammation in patients diagnosed with asthma. Based on this study and an
earlier Phase III clinical trial that was the basis of marketing approval in Australia and Europe, we plan to apply for marketing approval of Aridol in the U.S. We are also developing Bronchitol, our proprietary inhaled dry powder mannitol
formulation, for the treatment of cystic fibrosis, or CF, as well as chronic obstructive pulmonary disease, or COPD, an umbrella term for diseases such as bronchiectasis and chronic bronchitis. In August 2007 we reported a Phase III clinical trial
of Bronchitol for bronchiectasis in Europe and Australia. The study demonstrated a highly significant improvement in quality of life after 13 weeks of treatment with Bronchitol as assessed by the St George Respiratory Questionnaire, a significant
improvement in quality of life compared to placebo and a highly significant change in mucus clearance on patients receiving Bronchitol versus those patients receiving placebo. We had previously completed a Phase II clinical trial of Bronchitol in
bronchiectasis patients and demonstrated a clinically meaningful increase in patients quality of life relative to placebo. In April 2007 we commenced a Phase III clinical trial of Bronchitol in patients with CF in Europe and Australia. In 2005
we completed a Phase II clinical trial of Bronchitol in patients with CF and demonstrated a statistically significant improvement in lung function relative to placebo over a two week treatment period. We have agreed with the U.S. Food and Drug
Administration, or the FDA a protocol for a U.S. Phase III clinical trial of Bronchitol for the treatment of CF and we are in discussion with the FDA in relation to the protocol for a Phase III clinical trial of Bronchitol for the treatment of
bronchiectasis. The FDA has granted Orphan Drug designation to Bronchitol for the treatment of both bronchiectasis and CF for patients at risk for developing bronchiectasis. We believe that all CF patients are at risk for developing bronchiectasis.
The EMEA has granted Orphan Drug designation to Bronchitol for the treatment of CF. Our preclinical pipeline is focused on novel treatments for other inflammatory/immune disorders, including multiple sclerosis and asthma.



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The following table summarizes our current product candidates. All time periods set forth in the table
below refer to calendar years.



|                                            |  |                                                                                                                                                                                                                                                                                                                                                                                                                   |  |                                                                                                                                                                                                                                                                
|------------------------------------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Product Candidate / Indication              |  | Development Status                                                                                                                                                                                                                                                                                                                                                                                                |  | Next Anticipated Milestones                                                                                                                                                                                                                                    
|Aridol                                      |  |                                                                                                                                                                                                                                                                                                                                                                                                                   |  |                                                                                                                                                                                                                                                                
|                                            |  |                                                                                                                                                                                                                                                                                                                                                                                                                  
|Asthma: diagnosis and management            |  |         Approved for marketing Australia and Europe
         Sales commenced in Australia (2006) and first European countries (Sweden, 2007)          Two pivotal Phase III trials complete (October 2006)          Filed
Korean marketing application (July 2007)                                                                                                                                            |  |         Submit NDA to the FDA (1H08)          Korean
marketing approval (1H08)                                                                                                                                                                               
|                                            |  |                                                                                                                                                                                                                                                                                                                                                                                                                  
|COPD: clinical response to inhaled steroids |  |         Phase IIa clinical trial complete (March 2007)                                                                                                                                                                                                                                                                                                                                                           |  |         Report independent investigator-led clinical trial (1H08)                                                                                                                                                                                             
|                                            |  |                                                                                                                                                                                                                                                                                                                                                                                                                  
|Bronchitol                                  |  |                                                                                                                                                                                                                                                                                                                                                                                                                   |  |                                                                                                                                                                                                                                                                
|                                            |  |                                                                                                                                                                                                                                                                                                                                                                                                                  
|Cystic fibrosis                             |  |         Phase II trial complete          Granted Orphan Drug by the U.S. FDA and E.U. EMEA          Phase II dose-ranging clinical trial in progress          Investigator sponsored clinical trial with dornase alfa in progress          Fast Track designation by the U.S. FDA          First
Phase III clinical trial in progress          Approval received to commence second Phase III trial by FDA |  |         Initiate U.S. Phase III clinical trial
(1H08)          Report Phase II dose-ranging clinical trial (1H08)          Report Investigator Sponsored clinical trial with dornase alfa
(1H08)          Report first Phase III clinical trial data (2H08)
|                                            |  |                                                                                                                                                                                                                                                                                                                                                                                                                  
|COPD  bronchiectasis                       |  |         International Phase III trial complete          Orphan
Drug designation from the U.S. FDA                                                                                                                                                                                                                                                                                                               |  |         Initiate U.S. Phase III clinical trial
(1H08)          Scientific review meeting with EMEA (1H08)          Submit marketing application to Australian TGA (1H08)                                                                                    
|                                            |  |                                                                                                                                                                                                                                                                                                                                                                                                                  
|COPD  chronic bronchitis                   |  |         Pilot clinical trial                                                                                                                                                                                                                                                                                                                                                                                     |  |         Complete pilot clinical trial (1H08)                                                                                                                                                                                                                  
|                                            |  |                                                                                                                                                                                                                                                                                                                                                                                                                  
|PXS25/64                                    |  |                                                                                                                                                                                                                                                                                                                                                                                                                   |  |                                                                                                                                                                                                                                                                
|                                            |  |                                                                                                                                                                                                                                                                                                                                                                                                                  
|Multiple sclerosis                          |  |         Pre-clinical toxicology studies                                                                                                                                                                                                                                                                                                                                                                          |  |         File IND (1H08)                                                                                                                                                                                                                                       
|                                            |  |                                                                                                                                                                                                                                                                                                                                                                                                                  
|VAP-1 Research Program                      |  |                                                                                                                                                                                                                                                                                                                                                                                                                   |  |                                                                                                                                                                                                                                                                
|                                            |  |                                                                                                                                                                                                                                                                                                                                                                                                                  
|Asthma                                      |  |         Research to identify preclinical development candidate                                                                                                                                                                                                                                                                                                                                                   |  |         Nominate IND candidate (1H08)                                                                                                                                                                                                                         

Lung Disease Overview

Our lead product and product candidates are for the diagnosis and treatment of chronic respiratory diseases, including asthma, cystic fibrosis and COPD, including bronchiectasis and chronic bronchitis. Several of
these diseases share similar biology and pathology, such as the airway inflammation in both asthma and chronic bronchitis, as well as difficulty with normal clearance of lung mucus in patients with cystic fibrosis and bronchiectasis.



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Lung Congestion

The inside lining of the airways is covered by millions of fine hair-like structures called cilia, which are in turn covered by a surface liquid and a thin layer of mucus, secreted by the lungs to defend against
germs, dust particles and other extraneous matter. The cilia move continuously and propel the mucus up towards the throat. This constant process, which is unnoticeable in healthy people, cleans the airways, permits clean air to pass freely through
the lungs and removes bacteria, thereby limiting infectious episodes.

Patients with COPD or with CF are generally affected by a breakdown
in natural mechanisms of creating, hydrating, and clearing this mucus. These patients face the ongoing challenge of clearing excessive and thickened secretions from their congested lungs, usually by constant coughing. A key therapeutic goal for
clinicians treating these patients is to assist the natural process of keeping the mucus hydrated and clearing it from the lungs.

Cystic Fibrosis

CF is an inherited, progressive and fatal disease that affects epithelial surfaces including the airways,
pancreas, sweat ducts, reproductive system and intestinal tract. The lungs of CF produce copious amounts of thick, tenacious secretions which are not cleared effectively by the lungs. Such changes are known to be present from birth and inevitably
result in airway obstruction and bacterial infection. This generally leads to progressive lung deterioration, and eventually respiratory failure, the primary cause of death in adult CF patients.

According to Datamonitor, in 2002 there were 30,000 diagnosed CF patients in the U.S. and 65,000 in the seven major pharmaceutical markets. While this
patient population is relatively small, the problem of sputum clearance is common to all sufferers and is a chronic lifelong problem. We believe that the annual healthcare cost for patients in the United States is over U.S.$1 billion.

There is no cure for CF. Maintaining a reasonable quality of life for these patients is a significant challenge. Problems include breathing difficulties,
respiratory infections, poor sleep, general discomfort, lifestyle limitations and gradual deterioration of lung function over time. Although the life expectancy of CF sufferers has increased dramatically over the past few decades due to better
management of the disease, according to the U.S. Cystic Fibrosis Foundation, the predicted median age of survival in 2005 was 36.5 years of age.

Physicians seek to improve lung function and reduce the number and severity of secondary lung infections by hydrating and breaking down the excessive, sticky mucus secretions, allowing it to be cleared from the lungs. Management of CF
includes exercise, daily physiotherapy, postural drainage and chest percussion and can take several hours of at-home treatment every day. Medications to treat CF are limited, and few are very effective or convenient. Nebulised medications, delivered
by aerosol or a facemask, are used to make the mucus less thick and sticky and open up the airways. Antibiotics may also be required to treat secondary infections, and are also often used to prevent infection.

Dornase alfa, marketed by Genentech in the U.S., is the most widely used therapeutic for chronic use in CF to aid sputum clearance. According to
Hoffman-La Roche Inc., sales of dornase alfa were approximately U.S.$367 million in 2006. We estimate that this represents a market penetration in developed countries and the seven major pharmaceutical markets of about 30%. Although dornae alfa
demonstrates lung function improvement in CF patients, similar benefit was not shown in other respiratory conditions, including bronchiectasis. Further, in previous clinical trials, dornase alfa provided no increase in sputum clearance. dornase alfa
is unstable and is delivered by a nebulizer. Solutions have to be prepared by the patient before administration, the treatment periods are long and all equipment has to be sterilized after use.

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease, or COPD, encompasses a number of serious conditions affecting the lungs, including emphysema, chronic bronchitis and bronchiectasis. According to Datamonitor, there are 16 million people diagnosed
with COPD in the U.S., and more than 30 million people are affected with COPD in the seven major pharmaceutical markets. In 2000, COPD was estimated to be responsible for the deaths of more than 119,000 people in the U.S. alone, making it the
fourth leading cause of death after heart disease, cancer and stroke. In the United States, there are more than 10 million physician office visits and two million hospitalizations per year. The disease was estimated to cost the U.S. healthcare
system U.S.$30 billion in 2000. According to a report by



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Datamonitor, worldwide sales in 2004 of the top seven respiratory therapeutics indicated for COPD were U.S.$4.8 billion.

Current management of COPD generally involves bronchodilators and steroids. However, only an estimated 20%-25% of patients respond positively to steroids
and it is not practical to determine in advance which patients will respond to steroids. We believe that only half of moderate and severe COPD patients achieve an adequate treatment outcome. Therefore, as with asthma, we believe there is room to
improve both the diagnosis and management of COPD.

Bronchiectasis

In this condition the bronchial tubes become enlarged and distended, and the cilia do not function normally. Many patients with cystic fibrosis and asthma
may also have bronchiectasis. For other patients, bronchiectasis is a result of infections such as pneumonia, or the chronic inhalation of noxious substances although in over half the case, the underlying cause is never identified. The condition
results in poor clearing of mucus and predisposes the lung to more infections. The body repairs damaged lung tissue by forming tough, fibrous material, which leads to reduced lung function, lower lung efficiency, changes of the organization of blood
vessels and increased blood flow through the lungs. These changes impair normal lung function and can ultimately lead to heart failure. Recurrent lung infections commonly reduce patients quality of life and progressive respiratory
insufficiency is the most common cause of death from this disease. Based on research carried out for us by Datamonitor and Frost &Sullivan, we estimate that there are about 600,000 people worldwide seeking treatment for bronchiectasis and about
110,000 people in the U.S.

Bronchiectasis treatment is aimed at controlling infections, increasing secretions, reducing airway
obstructions and minimizing complications. Daily drainage to remove bronchial secretions is a routine part of treatment. Physicians often prescribe medications similar to those for chronic bronchitis, including inhaled bronchodilators to dilate the
airways. Although antibiotics can be used to some effect to clear infections, no currently approved products effectively clear excess mucus secretions and improve the quality of life of these patients. Furthermore, because of the serious damage to
lung tissue present in these patients, medications generally do not provide substantial improvement in lung function.

Chronic
Bronchitis

Patients with chronic bronchitis experience persistent airway inflammation and airflow obstruction, with symptoms including
a chronic mucus-producing cough and shortness of breath. Due to the difficulties they have in clearing mucus from their lungs, sufferers are prone to periodic bacterial infections where their cough worsens, mucus production increases and breathing
becomes more difficult. These episodes damage and scar the bronchial lining and contribute to continued chronic inflammation and immune-mediated cell damage as the body struggles to fight the infections. This cycle of infection and internal scarring
causes a progressive decline in lung function, reducing quality of life and ultimately causing death.

Many of the deaths associated with
chronic bronchitis are included in the COPD figure that now accounts for over 100,000 deaths a year in the U.S. The disease is predominately caused by inhaling some form of lung irritant repeatedly for many years, usually cigarette smoke. Chronic
bronchitis is slow to develop and is often not diagnosed until the sufferer is in their 40s or 50s.

Management of chronic bronchitis
includes various general supportive measures such as giving up smoking, limiting exposure to dust and chemicals, avoiding sudden temperature changes, undertaking chest physiotherapy and deep-breathing exercises, and increasing fluid intake to keep
the bronchial secretions thin. While there are a number of medications that dilate the airway and reduce airway inflammation, for chronic bronchitis sufferers, there are few therapeutic products available to effectively clear excess mucus
secretions. This presents a major medical challenge, as ineffective mucus clearance is a major cause of infection and progression of the disease.

Treatments for chronic bronchitis include anti-cholinergic agents, steroids, antibiotics and oxygen. Anticholinergic agents, also known as antimuscarinics, are bronchodilators used for the relief of acute symptoms in both asthma and COPD,
but tend to be more effective in COPD. Inhaled corticosteroids are less likely to cause systemic side effects than oral corticosteroids, and have been shown to be effective in asthmatics. However, the role of these agents in the management of COPD
remains unclear. Inhaled steroids are effective in controlling



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inflammation in the lung, but based on a recent publication by Leuppi et al., they are only effective in about 20%-25% of cases of patients with COPD.

Asthma

Asthma is a
chronic inflammatory disease of the lungs where the airways narrow in response to a variety of stimuli. Published estimates indicate that this disease affects over 20 million people in the U.S. and approximately 51 million people in the
seven major pharmaceutical markets of the U.S., Germany, France, United Kingdom, Italy, Spain, and Japan. Based on published studies, we estimate that each year in the U.S., 4.7 out of every 1,000 people under the age of 16 are newly diagnosed with
asthma and two out of every 1,000 people aged 16 to 44 are newly diagnosed with the disease.

Many patients with asthma are not currently
diagnosed with the disease. Sufferers and even physicians often attribute common asthma symptoms, such as cough and breathlessness, to smoking, lack of fitness or old age. Moreover, according to a recent publication, 34% of individuals diagnosed as
asthmatic by their primary care physician do not have the disease. Even when accurately diagnosed, many patients do not receive the most appropriate therapy according to published guidelines. Physicians can underestimate the severity of the disease,
and prescribe only bronchodilators, whereas the addition of an inhaled corticosteroid is the recommended course of action according to the Global Initiative for Asthma, or GINA, guidelines. We estimate that only about 30% of asthma patients in the
U.S. receive inhaled corticosteroids despite evidence that uncontrolled asthma is common. Poorly controlled asthma can lead to irreversible damage to the airways. Therefore, the goal of treatment is to provide sufficient anti-inflammatory medication
to control inflammation and airway remodeling. However, using high doses of medication can lead to unwanted side effects. Hence, selecting the right dose for individual patients remains a clinical problem.

To diagnose asthma and to evaluate patient response to treatment, pulmonary specialists may, for example, introduce an aerosolized substance directly
into the lungs, and subsequently test lung function. The tests fall into two categories. The first category, known as direct challenge tests, use either histamine or methacholine to directly cause airway narrowing. These substances act
on receptors on bronchial smooth muscle to cause contraction. The second category, known as indirect challenge tests, involve stimuli such as exercise, rapid breathing of dry air, or inhalation of salt solutions or adenosine
monophosphate. This more closely mimics an asthmatic process, and can cause the release of chemicals from inflammatory cells within the lungs, resulting in airway contraction and narrowing.

The only FDA-approved direct test is Provocholine® (methacholine), marketed by Methapharm Inc. We believe that the disadvantage of direct tests are that the airway narrowing caused by histamine or methacholine is not dependent on the presence of inflammatory cells,
and thus has a poor sensitivity for identifying people with active airway inflammation. Moreover, a positive response is not specific for identifying asthma and can occur in healthy people with no symptoms, smokers, and those with other diseases of
the lung. Despite these limitations, we believe that over 200,000 direct tests are performed each year in the U.S., based on information reported by Solucient LLC in 2003. However, this represents only a small fraction of the potential market.

We believe that the indirect tests have a much lower false positive rate for asthma and increased sensitivity. However, each of them
suffers from limitations. For example, tests involving exercise and rapid breathing of dry air require a lengthy period of time to complete and they require complicated equipment. Furthermore, these tests are limited to identifying exercise induced
asthma and are not useful for determining the severity of airway inflammation. Hypertonic saline, which is delivered by a nebuliser during administration of the test, is uncomfortable for the patient, determination of the administered dose is
difficult and this procedure is unsuitable for managing anti-inflammatory drug treatment. Adenosine monophosphate is unstable, also delivered by a nebuliser and its use is restricted to specialist research laboratories.

Bronchitol

We are developing Bronchitol, our
proprietary inhaled mannitol formulation, for the treatment of chronic obstructive lung diseases, including cystic fibrosis, bronchiectasis and chronic bronchitis. Mannitol is accepted as a



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food additive in the U.S. and is included in the FDA Inactive Excipients Guide for drug products. We manufacture mannitol into a dry respirable powder and
incorporate it into a capsule. The compound is delivered to a patients lungs via a pocket-sized inhaler. In a 12 week Phase III clinical trial involving 362 bronchiectasis patients sponsored by us, Bronchitol demonstrated a highly significant
improvement in quality of life and a significant improvement in quality of life relative to placebo and a highly significant improvement in mucus clearance relative to palcebo. Previously, in a Phase II clinical trial sponsored by us and involving
60 patients with bronchiectasis, Bronchitol provided a statistically-significant increase in patients quality of life relative to placebo and a highly statistically significant reduction in the symptoms of the disease. In a Phase II trial
involving 39 cystic fibrosis patients sponsored by us, Bronchitol provided a statistically significant reduction in airway obstruction and improvement in lung function. Patients have used Bronchitol at home successfully for over 12 months without
any serious adverse events. We initiated an international pivotal Phase III clinical trial of Bronchitol for the treatment of cystic fibrosis in April 2007 in Europe and Australia. This is the first of two planned trials for this indication, the
second trial is planned to commence in 2008 in the U.S. In addition, a U.S. Phase III clinical trial for bronchiectasis is scheduled to commence during the first half of 2008. We have an exclusive, worldwide license from Sydney South West Area
Health Service to certain key intellectual property and patents relating to the use and formulation of Bronchitol.

Mechanism and Early
Data

Bronchitol increases mucociliary clearance in asthmatic and healthy subjects. We have shown that a single inhalation of Bronchitol
increases the clearance of mucus both acutely and over a 24 hour period in patients with bronchiectasis, and acutely in patients with cystic fibrosis. The precise mechanism whereby Bronchitol increases the clearance of mucus remains unclear. One
possibility is that Bronchitol increases the clearance of mucus by changing its viscosity through disruption of hydrogen bonds that join the oligosaccharides in the mucin macromolecules. A second possibility is that Bronchitol increases hydration of
the airway surface by drawing water towards the airway surface by osmotic pressure and enhancing cilia beat frequency. Our data in human patients and animal models support both hypotheses.

In an investigator-sponsored 19 patient, single-dose Phase II clinical trial of Bronchitol in patients diagnosed with bronchiectasis, an increase in
whole lung mucus clearance was observed over a 75 minute period beginning at the onset of intervention and this increase was statistically significant (p<0.005). There was an almost doubling of mucus clearance after Bronchitol treatment and most
of this was in the central and intermediate regions of the lung. Over a 24 hour period after Bronchitol intervention the increase in mucus clearance was approximately 30% over control and this was statistically significant (p<0.0001).

Bronchitol for CF

In August 2005, we announced results from a company sponsored Phase II clinical trial involving 39
patients with cystic fibrosis. The placebo-controlled trial was conducted at eight sites in Australia and New Zealand. Patients were treated for two weeks with either Bronchitol or placebo. After a two week washout period where patients received
neither drug or placebo, patients who previously received Bronchitol were treated with placebo, and vice versa. This crossover trial design allows each patient to act as their own control. The primary endpoint was change in Forced Expiratory Volume
in 1 second, known as FEV1. This is a quantitative measure of the volume of air a patient can exhale in one second, and is the most frequently used measure
of the degree of airway obstruction. The secondary endpoints included quality of life, sputum microbiology, the physical properties of sputum, safety and additional lung function measurements. At the end of the treatment period, patients receiving
Bronchitol had significantly better lung function compared to placebo as measured by FEV1and for the maximum mid-expiratory flow, or MMEF, another measure
of airway function. Approximately half the subjects were using dornase alfa during the trial.

In this trial, Bronchitol had a positive impact on lung function. Patients who received Bronchitol had a 7% improvement in FEV1as compared to placebo (p=0.008). MMEF increased by 15% while on Bronchitol treatment and this increase was significant compared to control (p<0.01). The MMEF reflects function in small airways and is an early abnormality in cystic
fibrosis. Respiratory symptoms determined from a Likert scale self-assessment after Bronchitol treatment were significantly improved as compared to placebo (p<0.02).

In August 2005, the FDA granted Orphan Drug designation to Bronchitol for the treatment of cystic fibrosis. In November 2005, the European Medicines
Agency, or EMEA, granted Orphan Drug designation to Bronchitol for the treatment of cystic fibrosis. In November 2006, Bronchitol was awarded Fast Track designation



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by the FDA for cystic fibrosis, making Bronchitol eligible to apply for accelerated approval. We have initiated additional clinical trials of Bronchitol for
the treatment of cystic fibrosis. In December 2005, we an independent investigator-led Phase II clinical trial commenced comparing the effect on lung function of Bronchitol and dornase alfa to either drug alone. This independent investigator-led
trial completed enrolment in February 2007 and is expected to report in the first half of 2008. We also started a dose-ranging Phase II trial to determine optimal dosing. In April 2007 we initiated a pivotal Phase III clinical trial in the E.U. and
Australia, to provide the basis for applications for marketing authorization in the E.U. and Australia. In August 2007, we requested a Special Protocol Assessment review with the FDA to commence a U.S. Phase III trial with Bronchitol in cystic
fibrosis to provide the basis for application for marketing authorization in the U.S.

We believe that the addressable annual market for
Bronchitol in CF is the 65,000 diagnosed CF patients in the seven major pharmaceutical markets.

Bronchitol for Bronchiectasis

In 2004 we completed a proof of concept Phase II clinical trial of Bronchitol in 60 bronchiectasis subjects. We began this
comparator-controlled, crossover design trial at a single center in Sydney and later expanded it to include four centers in Australia and New Zealand. This trial was designed to explore the safety and efficacy of Bronchitol in bronchiectasis
patients. Patients received 400 mg of Bronchitol or comparator, twice a day for 14 days. In this trial, the comparator was a mannitol formulation with a larger (non-respirable) particle size, which we anticipated to be most similar in patient
experience to active Bronchitol, yet was intended not to enter the lungs to any significant degree. Endpoints of the study were to evaluate the effect of Bronchitol treatment on patient qualify of life using a self-assessment known as the Likert
scale, the St. Georges Hospital Respiratory Questionnaire, or SGRQ, which is another self assessed measure of quality of life, sleep quality as measured by the self assessed Epworth scale, exercise tolerance as measured by the 6 minute walk test,
lung function as measured by two tests known as spirometry and flow oscillometry, sputum microbiology, the physical properties of sputum, the volume of sputum production over 24 hours and the safety profile of Bronchitol. The SGRQ includes changes
in three components, symptom, activity and impact, as well as an overall score. Improvement in quality of life measures is indicated by a reduction in score.

Versus baseline, treatment with Bronchitol led to a significant reduction in the Likert scale score of 6.1 (p=0.03). Versus baseline and comparator, there was a statistically significant improvement in the Epworth
sleep score (p<0.02 versus comparator). For patients receiving Bronchitol, 38% went from an unclear chest to a clear chest as compared to 17% on comparator (p<0.05). There was no statistically significant changes on lung function as measured
by standard spirometry. Flow oscillometry showed a significant effect of Bronchitol compared to comparator (p<0.05). Flow oscillometry is considered to reflect changes in small airways.

However, the effect of Bronchitol was most pronounced in the 75% of patients who entered the study with an unclear chest, which indicates the most
serious problems with normal clearance of lung mucus. There was a mean decrease of 10.2 in Likert scale score during Bronchitol treatment, compared to a mean decrease of 3.6 for placebo (p<0.005 versus placebo). Treatment with Bronchitol led to a
significant improvement in the impact component of the SGRQ compared to comparator in those patients with an unclear chest. The improvement was clinically significant at 6.9 points. There was also a trend for an effect on the total score versus
comparator but this did not reach significance (p=0.15). Compared to baseline, the overall score showed a strong trend with a clinically significant reduction of 5.6 (p=0.055).

In August 2007 we completed a Phase III clinical trial of Bronchitol in 362 bronchiectasis subjects. This comparator-controlled double blinded trial was
conducted over 22 sites in the United Kingdom, Australia and New Zealand. The trial was designed to evaluate the safety of Bronchitol and its impact on quality of life and mucus clearance. In this trial, the comparator was a mannitol formulation
with a larger particle size, which we anticipated to be most similar in patient experience to active Bronchitol, yet was intended not to enter the lungs to any significant degree. Primary efficacy endpoints of the study were to evaluate the effect
of Bronchitol treatment on patient qualify of life using a self-assessed questionnaire, known as the St. Georges Hospital Respiratory Questionnaire, or SGRQ, which is a patient reported outcome tool for measuring health-related quality of life, and
24 hour mucus clearance. The SGRQ includes changes in three components, symptom, activity and impact, as well as an overall score. Improvement in quality of life measures is indicated by a reduction in score. Subjects were



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administered drug or comparator over a twelve week period and the randomization was 2:1 in favor of the treatment arm.

Treatment with Bronchitol led to an overall improvement in quality of life versus baseline (p<0.001) and an overall improvement in quality of life versus the
comparator (p<0.05). The change in quality of life was clinically significant at 4.1 units at the mid-point of the study and 3.9 units at the end of the study. Additionally, there was a significant difference in sputum volume between the two
groups of subjects, with the Bronchitol treated group producing significantly more mucus over the 24 hour collection periods. There were no serious adverse events attributable to treatment and there was no statistical difference in the number or
nature of adverse events in the two treatment groups.

No therapies to enhance mucus clearance in bronchiectasis patients have been
approved in over 20 years in the U.S. In August 2007, we requested a Special Protocol Assessment review with the FDA to commence a U.S. Phase III trial with Bronchitol in bronchiectasis to provide the basis for application for marketing
authorization in the U.S.

In February 2005, the FDA granted Orphan Drug designation to Bronchitol for the treatment of bronchiectasis. We
are currently supplying Bronchitol in Australia on an individual, named patient basis under a TGA-administered compassionate use program known as the Special Access Scheme. This program allows patients access to unapproved drugs where there are
limited treatment options.

We believe that an effective daily treatment for the estimated 600,000 people worldwide affected by
bronchiectasis represents a significant market opportunity.

Bronchitol for Chronic Bronchitis

Pilot data in patients with chronic bronchitis have shown that Bronchitol may also be beneficial in improving ciliary and cough clearance in these
patients. We indirectly supported a small, investigator-sponsored Phase II clinical trial to determine the effects of Bronchitol on mucus clearance over a two hour period, and the effects on rate of clearance of a radiolabelled tracer over a 24 hour
period. The trial was not powered nor suitably controlled for statistical analysis, but provided encouraging data.

We plan to conduct
additional Phase II clinical trials in patients with chronic bronchitis. The objective of these trials will be to determine if Bronchitol assists in clearing mucus during an exacerbation and whether Bronchitol has the ability to shorten the
exacerbation period. Prior to conducting formal efficacy Phase II clinical trials we have embarked on a Phase Ib clinical trial involving 25 patients which is being conducted in hospitals in Australia. The objective of this trial is safety, as we
have not studied the effects of Bronchitol in patients that have extremely low lung functions in an inpatient hospital setting.

Aridol

We have initially developed Aridol as a more accurate and precise proprietary tool for physicians to use in the diagnosis and management of asthma and
COPD. Physicians do not currently have rapid, accurate, safe and inexpensive tests to evaluate the presence or severity of these diseases. Aridol is a proprietary dry powder formulation of mannitol, delivered to the lungs through an inhaler.
Mannitol is an osmotic agent which causes the release of certain mediators from inflammatory cells, which in turn cause a bronchoconstriction. This process mimics the changes that often occur in the airways of people with asthma . Asthma patients
who are not receiving adequate doses of anti-inflammatory medicine, such as an inhaled corticosteroid, experience airway narrowing and a drop in lung capacity when given the Aridol test. In contrast, healthy people or well-controlled asthma patients
do not experience this narrowing and reduction in lung capacity. In 2004 we completed a 646 subject, 12 center, Phase III clinical trial of Aridol. Based on the Phase III data, we have received marketing approval in Australia and Sweden and
successfully completed the E.U. mutual recognition procedure allowing for the issue of marketing authorizations in Germany, France, the United Kingdom, Italy, the Netherlands, Belgium, Denmark, Greece, Spain, Finland, Ireland, Norway and Portugal.
We have also filed for marketing approval in Switzerland and Korea. In October 2006 we completed a 500 participant, 30 center, Phase III clinical trial designed to allow approval in the U.S. Based on this study and the earlier Phase III clinical
trial that was the basis of marketing approval in Australia and Europe, we intend to file a New Drug Application (NDA) with the FDA. Based on independent research



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commissioned by us, we believe that the Aridol test will be reimbursable for the detection of airway hyper-responsiveness under current procedure codes in
the United States. Based on independent market research commissioned by us, we believe that the addressable annual market for Aridol in the U.S., Europe and Australia includes the 400,000 bronchial challenge tests performed yearly, 2 million
new tests for assisting the diagnosis of asthma, 16 million new tests performed by pulmonary specialists and primary care physicians for assisting the management of asthma, and 3 million new tests to evaluate steroid responsiveness in COPD
patients.

Aridol is the subject of 30 peer-reviewed publications in international journals. We believe that Aridol is superior to direct
tests such as methacholine because Aridol is an indirect challenge test that relies on mediators released by inflammatory cells to cause a bronchoconstriction, thereby making Aridol a more accurate predictor of airway inflammation. We believe that
Aridols high degree of sensitivity and specificity for airway inflammation, combined with its ease of use, will make it possible for physicians to:



| |  |  | diagnose asthma more accurately and objectively, and measure disease severity, with a high correlation to in-depth patient assessment by a pulmonary specialist
physician;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | monitor the effectiveness of treatment, with a negative Aridol test indicating good control of asthma and a positive test indicating active airway inflammation and
the need for more or different medication;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | determine the minimum required dose of steroids to achieve adequate disease control in a given patient, and predict the risk of exacerbation when reducing the
steroid dose; and
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | identify the 20%-25% of COPD patients who, according to a recent publication by Jörg Leuppi and colleagues, have a significant inflammatory component to their
disease which will respond to inhaled corticosteroids. We believe this will allow the reduction of unnecessary steroid usage and potentially lower healthcare costs.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We have an exclusive, worldwide license from Sydney South West Area Health Service to certain key intellectual property and patents relating to the use
and formulation of Aridol.

Aridol for Asthma

In our Phase II and Phase III clinical trials, patients use a dry powder inhaler to take progressively higher doses of Aridol (from 5 mg to 635 mg, nine steps in all). After each inhalation the patients lung
capacity is determined by a spirometer, an instrument to measure airflow and lung capacity. The Aridol test is stopped when a patient has a 15% fall in lung capacity, indicating the presence of active airway inflammation. Only those patients with
active airway inflammation will experience a drop in lung capacity. On average, the procedure takes 17 minutes for a positive test and 26 minutes for a negative test. The only equipment required is a standard spirometer to record lung capacity.

A large number of investigator-sponsored, open-label Phase I and Phase II clinical trials have been conducted with Aridol. The results
show that use of Aridol can identify subjects with asthma who are also responsive to inhaled salt solutions, inhaling dry air and exercise. Aridol also identifies both adults and children with currently active asthma who are responsive to
methacholine, as well as others who are not responsive to methacholine. The Aridol test demonstrates good repeatability in both adults and children, and responses are rapidly reversible using a standard dose of bronchodilator. Furthermore, Aridol
can provide an assessment of the effectiveness of inhaled steroids in controlling the disease. Finally, Aridol response correlates with the symptoms and signs of exercise induced asthma, indicating that a negative response to Aridol may be a useful
end point signifying adequate asthma control.

In 2004 we completed a 12 center, 646 subject, Phase III clinical trial of Aridol to
identify airway hyperresponsiveness in asthmatic patients, and to support filing for marketing authorization in Australia and the European Union. Airway hyperresponsiveness is a hallmark of untreated or poorly controlled asthma, and over time can
lead to long-term changes in the lungs. This trial included asthmatic patients who were currently treating their disease, patients with symptoms suggestive of asthma but without a clinical diagnosis, and healthy volunteers, including both children
and adults. The goals of this trial were to:



| |  |  | compare Aridol to hypertonic saline in identifying airway hyper-responsiveness in asthmatic subjects and non-asthmatic subjects;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------



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| |  |  | compare Aridol to standard clinical assessment in diagnosing asthma;
| | - |  | --------------------------------------------------------------------



| |  |  | compare asthma severity as determined by our Aridol test to the Severity of Asthma (Asthma Management Handbook 2002);
| | - |  | ---------------------------------------------------------------------------------------------------------------------



| |  |  | evaluate the advantages of Aridol versus hypertonic saline with respect to simplicity, safety and patient and health care convenience; and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | further evaluate the safety profile of Aridol.
| | - |  | ----------------------------------------------

The primary endpoint was a comparison of the sensitivity and specificity of Aridol to that for an unapproved test, hypertonic saline, which is widely used in Australia. A secondary endpoint was a comparison of the
sensitivity and specificity of Aridol to that of physician diagnosis. Sensitivity is a measure of the percentage of people correctly identified as having airway hyperresponsiveness by the test. Specificity is a measure of the percentage of people
correctly identified as lacking airway hyperresponsiveness.

In this trial, sensitivity of Aridol against hypertonic saline was 81%, and
specificity was 87%. This means that 81% of patients identified as having airway hyper-responsiveness by the hypertonic saline test were also identified as positive by the Aridol test and 87% of patients classified as lacking airway
hyper-responsiveness were also identified as negative by Aridol. Conversely, the sensitivity of hypertonic saline against Aridol was 88%, and specificity was 79%. These numbers indicate good agreement between the two tests (p<0.01).

In comparison to physician diagnosis, Aridol had a sensitivity of 58%, and specificity was 94%. Significantly, of the 42% of patients identified as
asthmatic by physician diagnosis, but lacking airway hyper-responsiveness as determined by Aridol, 85% were using inhaled corticosteroids at the time of the clinical trial. When the subjects who were Aridol negative and were using inhaled
corticosteroids were removed from the analysis versus physician diagnosis, sensitivity was 89% and specificity was 95%. The increase in sensitivity underscores the utility of Aridol in managing patients on inhaled corticosteroid medication.

As a result of this trial, we have received marketing approval in Australia and Sweden and successfully completed the E.U. mutual
recognition procedure allowing for the issue of marketing authorizations in Germany, France, the United Kingdom, Italy, the Netherlands, Belgium, Denmark, Greece, Spain, Finland, Ireland, Norway and Portugal. We have also filed for marketing
approval in Switzerland and Korea. We have established a sales force based in Australia and have completed our first year of sales of Aridol in Australia. We have appointed independent marketing partners in Scandinavia, Switzerland, Italy, Greece,
Spain and Holland and established an office in the United Kingdom to manage these partners and to manage sales and marketing in the UK, Ireland and France. We have applied for marketing approval in South Korea and have appointed an independent
marketing partner in that country. We intend to establish additional marketing partnerships in select E.U. territories and other jurisdictions for this product. We are supporting a number of investigator-sponsored trials to provide the basis for a
rapid uptake of Aridol in the marketplace.

In the U.S., unlike Australia and Europe, a product, methacholine, is approved by the FDA to
identify airway hyper-responsiveness in asthmatic patients. Based on discussions with the FDA, we undertook a 500 subject Phase III clinical trial comparing Aridol with methacholine and exercise challenge in patients with suspected asthma. The
primary endpoint was to compare the sensitivity and specificity of Aridol to identify exercise-induced bronchoconstriction. We completed this trial in October 2006. In this group with predominantly very mild symptoms, Aridol was able to identify
patients with exercise induced bronchoconstriction in 58% of cases (sensitivity). In comparison methacholine, an approved lung function test in the U.S., identified 54% of cases. The difference between the two tests was not statistically
significant. Aridol also had similar specificity to methacholine, (66% versus 70% respectively) in subjects without exercise induced bronchoconstriction. In addition Aridol was proven to have an acceptable safety profile and to cause less
bronchoconstriction than methacholine (p<0.05). Based on this study and the earlier Phase III clinical trial that was the basis of marketing approval in Australia and Sweden, we intend to file a New Drug Application (NDA) with the FDA.

Our initial target market for Aridol is the 50% of symptomatic asthmatics that are not diagnosed by physicians, as well as patients whose
disease is poorly controlled. Because current use of objective lung function testing is low, we plan to focus initial Aridol marketing efforts on physician education regarding asthma diagnosis



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and disease control. We believe physicians who commonly diagnose asthma based only on patient history of asthma symptoms leads to sub-optimal control of this
disease, falling far short of the goals of current clinical guidelines. We are also planning development and marketing efforts in new areas where challenge testing could be useful given the availability of an accurate, valid and easy to use test
like Aridol. These include monitoring asthma therapy and assessing asthma prevalence in the community.

Based on independent market
research commissioned by us, we believe that the addressable annual market for Aridol in the U.S., Europe and Australia includes the 400,000 bronchial challenge tests performed yearly, 2 million new tests for assisting the diagnosis of asthma
and 16 million new tests performed by pulmonary specialists and primary care physicians for assisting the management of asthma.

Aridol for COPD

We are also exploring the use of Aridol in the management of COPD. Treatment of COPD is difficult but
approximately 20%-25% of patients with COPD can have a positive clinical outcome with the administration of inhaled steroids. A long standing problem is that there is no effective test to identify those people that will respond clinically to inhaled
steroids. A recent publication by Jörg Leuppi and colleagues has shown that in an investigator-sponsored, Phase II clinical trial, those patients with COPD that have a positive response to an Aridol challenge test are likely to benefit from
inhaled corticosteroids treatment. In this trial, all patients had a positive response to inhaled histamine (a lung challenge test) whereas only 23% had a response to inhaled Aridol. After three months treatment with steroids, only those patients
who recorded a positive Aridol challenge test had an improvement in their lung capacity. The difference in response to treatment between the two groups was highly statistically significant (p=0.001). In March 2007 we reported the results of a Phase
II clinical trial to determine if Aridol is a practical test to guide treatment of inhaled corticosteroids in COPD patients in the primary care setting. In subjects with a positive Aridol challenge test, treatment with inhaled corticosteroids led to
a highly statistically significant improvement in hyper-responsive airways as judged by a subsequent Aridol challenge test.

Based on
independent market research commissioned by us, we believe that the addressable annual market for Aridol in the U.S., Europe and Australia includes 3 million new bronchial challenge tests to evaluate steroid responsiveness in COPD patients.

PXS25/PXS64

We currently conduct an
active research program designed to prevent the inappropriate migration of immune cells from blood to surrounding tissue. Our lead compounds in this program are PXS25 and PXS64, a derivative of PXS25 that is orally available in our preclinical
studies. Our preclinical studies indicate that PXS25 prevents immune cell migration and is effective in animal models of multiple sclerosis and rheumatoid arthritis. We are currently developing PXS64 as an oral treatment for acute exacerbations of
multiple sclerosis, and are evaluating its potential in other inflammatory/autoimmune diseases such as asthma.

Background

A key element of inflammatory diseases such as multiple sclerosis and rheumatoid arthritis is the migration of white blood cells known
as leukocytes from blood vessels into surrounding tissue. After binding to the inside surface of blood vessels, the leukocytes produce enzymes which allow them to move into adjacent tissue. These enzymes are anchored to the leukocytes through a
protein found on the surface of these cells, known as the mannose phosphate receptor, or MPR.

Multiple sclerosis, or MS, is a disease
where the patients own immune system attacks the protective myelin sheath that insulates nerve fibers, or axons, in the central nervous system and the cells that make myelin, the oligodendrocytes. The symptoms of MS result from both the loss
of signal conduction in demyelinated axons and the loss of the axons themselves. Under normal circumstances the blood-brain barrier protects cells in the central nervous system, or CNS, from leukocytes found in the rest of the body. However, in MS
patients activated T-cells are able to cross the blood-brain barrier by secreting proteases and thereby enter the CNS.

According to the
Mayo Clinic, there are approximately 1 million people affected by MS worldwide. There is no cure for the disease, although treatments do exist to slow progression of the disease. There are currently five



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main drugs on the market for the treatment of MS: three beta interferons, Copaxone® marketed by
Teva and Aventis, and Novantrone®, marketed by Serono. In addition, powerful immunosuppressive steroids such as prednisone are often used to treat patients in the acute relapsing phase of
the disease, the most serious and debilitating. Based on sales and reported market share estimates published in the annual reports of a number of the manufacturers of these five main drugs, we estimate the worldwide market for drugs to treat MS to
be approximately U.S.$3 billion per year.

PXS25/PXS64 for MS

We believe drugs that prevent activated leukocytes from entering the CNS will inhibit lesion formation and slow the progression of MS. PXS25 is a small molecule that acts as a specific blocker of the mannose phosphate
receptor, which blocks protease secretion and function in vitro. In animal models of MS, treatment with PXS25 has resulted in a reduction in peak severity of disease and accelerated recovery. PXS25 represents a new therapeutic approach to
treating multiple sclerosis and we believe the compound could have broad utility in slowing the progression of the disease.

In our animal
studies, PXS25 demonstrated significant activity when administered by injection. However, the oral bioavailability of PXS25 is low in several species of animals. Therefore, we have developed a prodrug of PXS25 which is metabolized to active PXS25
once absorbed by the body. However, in the first instance, we are developing PXS25 as an intravenous preparation to understand the behavior of the compound in humans before developing the oral molecule, PXS64. Our goal is to file an IND in the first
half of 2008 and to pursue an application for the treatment of multiple sclerosis.

Our Strategy

Our objective is to build a fully-integrated specialty pharmaceutical company focused on respiratory and inflammatory/autoimmune indications. Key aspects
of our strategy include:



| |  |  | Obtain international marketing authorization for Aridol. We have received marketing authorization of Aridol in Australia and Sweden and successfully
completed the E.U. mutual recognition procedure allowing for the issue of marketing authorizations in Germany, France, the United Kingdom, Italy, the Netherlands, Belgium, Denmark, Greece, Spain, Finland, Ireland, Norway and Portugal. We have also
filed for marketing approval in Switzerland and Korea. Based on our pre-IND meeting with the FDA, the completed U.S. clinical trial of Aridol and the earlier Phase III clinical trial that was the basis of marketing approval in Australia and Europe,
we intend to file a New Drug Application (NDA) with the FDA.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Successfully complete the clinical development of Bronchitol.We recently successfully completed our first Phase III trial in Europe and Australia of
Bronchitol for the treatment of bronchiectasis and have previously completed two successful Phase II trials of Bronchitol for the treatment of cystic fibrosis and bronchiectasis. We initiated our first Phase III trial in Europe and Australia of
Bronchitol for the treatment of cystic fibrosis in April 2007. In August 2007 we requested a Special Protocol Assessment review with the U.S. Food and Drug Administration to commence U.S. Phase III trials with Bronchitol for the treatment of
bronchiectasis and cystic fibrosis.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Focus on attractive product opportunities in our core therapeutic areas.We are developing products that address chronic respiratory and
inflammatory/autoimmune diseases. These markets are attractive opportunities because of the limitations of current treatment, the severity of these diseases, and because they are treated by a relatively concentrated physician audience.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Develop sales and marketing capabilities in select markets.We intend to retain commercial rights to our products in indications and territories where we
believe we can effectively market them with a small specialized sales force. For all other indications and territories, we intend to pursue strategic collaborations.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Continue to expand our R&D pipeline.We were founded in 1998 based on anti-inflammatory intellectual property we licensed from the Australian National
University. In 2001, we licensed intellectual property
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | that is the basis of Aridol and Bronchitol. We will continue to build and strengthen our product pipeline and commercial capabilities, and we may acquire
complementary technology and drug development candidates from research institutes, universities and private and public companies. These acquisitions may take the form of collaborations, licensing arrangements or outright purchase of intellectual
property, research groups or corporate entities. In 2006 we established a drug discovery unit based in laboratories at North Ryde, Sydney, which is focused on immune and respiratory drug discovery.
| | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Sales and Marketing

We have a sales and marketing
group in Australia and have appointed marketing and distribution partners for certain European territories with respect to the marketing and sale of Aridol. We have established a small office in the United Kingdom to manage these partners. Assuming
receipt of all necessary approvals of Aridol for commercial sale, we intend to use a combination of direct marketing to pulmonary specialists and third parties in the U.S. and Asia . In order to commercialize any of our other respiratory product
candidates, we must further develop these capabilities internally or through collaborations with third parties. We intend to retain commercial rights to market our products to pulmonary specialists in the United States and potentially in Europe.
Because the United States and European pulmonary specialist market is relatively concentrated, we believe we can effectively target it with a small specialized sales force. We may pursue strategic collaborations to commercialize our products in
other territories and on a worldwide basis for indications treated by large physician populations, such as asthma or arthritis.

Manufacturing

We manufacture both Aridol and Bronchitol in our production facility located in Sydney, Australia, under conditions of current Good
Manufacturing Practice, known as cGMP. In early 2005, we completed an expansion of our manufacturing facility that approximately tripled our manufacturing capacity. Our manufacturing facility consists of a warehouse, adjoining office space, a cGMP
laboratory for quality control and quality assurance, and clean rooms. Final packing of both Aridol and Bronchitol in blister packs is performed by a third party. The inhaler used in conjunction with Bronchitol is manufactured by Plastiape in Italy
and is supplied to us on a non-exclusive basis through a standard supply agreement.

We believe that our manufacturing facility has ample
operating capacity to produce adequate Aridol and Bronchitol to undertake the full clinical trial program through submission of an NDA in the U.S. for those product candidates and to support the commercial demand of Aridol two years after
international launch. We have recently entered into an agreement concerning the lease of a purpose built manufacturing, warehousing and office facility. Construction of the new facility is expected to commence in the fourth quarter of 2007 and is
expected to take approximately twelve months to complete. We have recently entered an agreement for the construction of a spray dryer, being the key piece of production equipment to be housed in the new facility and are continuing to prepare
specifications for other pieces of equipment which will be required to increase capacity.

Our cGMP facilities have been inspected and
licensed by the Therapeutic Goods Administration, or TGA, the Australian regulator analogous to the FDA. Our facilities and those of any third-party manufacturers will be subject to periodic inspections confirming compliance with applicable law,
including U.S. and European rules, should our product candidates receive approval in those jurisdictions. Our facilities must be cGMP certified before we can manufacture our drugs for commercial sale. Failure to comply with these requirements could
result in the shutdown of our facilities or the assessment of fines or other penalties.

Mannitol is the key raw material required for the
manufacture of both Aridol and Bronchitol. cGMP grade mannitol is available from a number of suppliers. Inhalers are also available from a number of suppliers.

We have outsourced the manufacturing of cGMP grade PXS25 for preclinical and clinical trials as our manufacturing facilities are not suitable for the production of PXS25. Our contract manufacturers have the capacity
to produce adequate PXS25 for clinical trials.

PXS64 is a small molecular entity synthesized from inexpensive and readily available
starting materials available from a number of different suppliers. The manufacture of PX64 is carried out by a contract manufacturer. We own all rights to the manufacturing process.



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We believe we are also able to produce sufficient PXS2076 for research studies.

Competition

We operate in highly competitive
segments of the biotechnology and pharmaceutical markets. We face competition from many different sources, including commercial pharmaceutical and biotechnology enterprises, academic institutions, government agencies, and private and public research
institutions. Many of our competitors have significantly greater financial, product development, manufacturing and marketing resources than do we. Large pharmaceutical companies have extensive experience in clinical testing and obtaining regulatory
approval for drugs. These companies also have significantly greater research capabilities than do we. In addition, many universities and private and public research institutes are active in respiratory and autoimmune disease research, some in direct
competition with us. We also compete with these organizations to recruit scientists and clinical development personnel. Smaller or early-stage companies may also prove to be significant competitors, particularly through collaborative arrangements
with large and established companies.

We are aware of many of our competitors in
each of the markets we target. These products include approved and marketed products as well as products in development. We expect Aridol, to compete with direct bronchiol provocation tests such as methacholine (Provocholine®) and histamine. We expect Bronchitol for CF to compete with or to be used in conjunction with Pulmozyme and other mucolytic agents and bronchodilators. Although it has little market
penetration, Mucomyst®, marketed by AstraZeneca, is used by some physicians to treat bronchiectasis, other forms of COPD and CF. Numerous other potential competing therapeutic products are
in clinical treatment and preclinical development, including new antibiotic preparations and new agents to restore salt balance. In each of our development programs addressing indications for which there are therapies available, we intend to
complete clinical trials designed to evaluate the potential advantages of our drug candidates as compared to, or in conjunction with, the current standard of care. Key differentiating elements affecting the success of all of our drug candidates are
likely to be their efficacy, convenience and side-effect profile compared to commonly used therapies.

Intellectual Property

We patent the technology, inventions and improvements that we consider important to the development of our business. As of October 31 2007, we owned
or had exclusive rights to 18 issued U.S. and foreign patents and 11 pending U.S. and foreign patent applications. Of these, nine issued patents and three pending applications relate to Aridol and Bronchitol. The last of these issued patents
are due to expire in 2021. One pending application relates to PXS25 and PXS64 and has now entered the national phase. The remaining patents and applications relate to other aspects of our technology or other drug discovery programs that have not yet
entered a full development program. If available to us, we intend to seek patent term extension for our eligible patents, including under the Hatch-Waxman Act, which provides up to five years of patent extension.

We have the exclusive worldwide rights from Sydney South West Area Health Service for certain key intellectual property and patents relating to the use
of respirable dry powders for the assessment of bronchial hyper-responsiveness, a condition consistent with active asthma, for monitoring steroid use in asthma patients, and enhancing mucus clearance in diseases such as cystic fibrosis,
bronchiectasis and chronic bronchitis. These exclusive rights, which form the basis for patent protection of both Aridol and Bronchitol, derive from one issued U.S. and eight issued foreign patents. The U.S. and most of the foreign patents covering
Aridol and Bronchitol are due to expire in 2015. The latest expiring in any territory is 2021. The U.S. and European patents may be eligible for extension by up to an additional five years, however, we cannot guarantee that any such extension would
be granted.

We also have an exclusive worldwide license from ANU Enterprises Pty Ltd. (formerly Anutech Pty Ltd.) to develop and
commercialize intellectual property relating to the treatment of inflammatory or immune-mediated conditions in patients by administering a phosphosugar. These exclusive rights derive from two issued U.S. and four issued foreign patents covering the
E.U. member states and Australia, as well as other major territories. The last of these patents are due to expire in 2017. The U.S. patents may be eligible for extension by up to an additional five years, however, we cannot guarantee that any such
extension would be granted.



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Our ability to build and maintain our proprietary position for our technology and drug candidates will
depend on our success in obtaining effective claims and enforcing those claims once granted. The patent positions of biopharmaceutical companies like ours are generally uncertain and involve complex legal and factual questions for which important
legal principles remain unresolved. Some countries in which we may sell our product candidates or license our intellectual property may fail to protect our intellectual property rights to the same extent as the protection that may be afforded in the
U.S. or Australia. Some legal principles remain unresolved and there has not been a consistent policy regarding the breadth or interpretation of claims allowed in patents in the United States, the European Union, Australia or elsewhere. In addition,
the specific content of patents and patent applications that are necessary to support and interpret patent claims is highly uncertain due to the complex nature of the relevant legal, scientific and factual issues. Changes in either patent laws or in
interpretations of patent laws in the U.S, the E.U.or elsewhere may diminish the value of our intellectual property or narrow the scope of our patent protection.

We may not be able to develop patentable products or be able to obtain patents from pending patent applications. Even if patents are issued, those patents can be challenged by our competitors who can argue such
patents are invalid. Patents also will not protect our products if competitors devise ways of making these product candidates without legally infringing our patents. The U.S. Federal Food, Drug and Cosmetic Act and FDA regulations and policies and
equivalents in other jurisdictions provide incentives to manufacturers to challenge patent validity or create modified, noninfringing versions of a drug in order to facilitate the approval of abbreviated new drug applications for generic
substitutes. In addition, patent applications filed before November 29, 2000 in the U.S. are maintained in secrecy until patents issue. Later filed U.S. applications and patent applications in most foreign countries generally are not published
until at least 18 months after they are filed. Scientific and patent publication often occurs long after the date of the scientific discoveries disclosed in those publications. Accordingly, we cannot be certain that we were the first to invent the
subject matter covered by any patent application or that we were the first to file a patent application for any inventions.

Government Regulation and
Product Approval

Regulation by governmental authorities in the United States and other countries is a significant factor in the
development, manufacture and marketing of pharmaceuticals. All of our products will require regulatory approval by governmental agencies prior to commercialization. In particular, pharmaceutical drugs are subject to rigorous preclinical testing and
clinical trials and other premarketing approval requirements by the FDA and regulatory authorities in other countries. In the United States, various federal, and in some cases state statutes and regulations, also govern or impact upon the
manufacturing, safety, labeling, storage, record-keeping and marketing of pharmaceutical products. The lengthy process of seeking required approvals and the continuing need for compliance with applicable statutes and regulations require the
expenditure of substantial resources. Regulatory approval, when and if obtained for any of our product candidates, may be limited in scope which may significantly limit the indicated uses for which our product candidates may be marketed. Further,
approved drugs and manufacturers are subject to ongoing review and discovery of previously unknown problems that may result in restrictions on their manufacture, sale or use or in their withdrawal from the market.

Preclinical Studies

Before testing
any compounds with potential therapeutic value in human subjects in the United States, stringent government requirements for preclinical data must be satisfied. Preclinical testing includes both in vitro and in vivolaboratory
evaluation and characterization of the safety and efficacy of a drug and its formulation. Preclinical testing results obtained from studies in several animal species, as well as from in vitrostudies, are submitted to the FDA as part of an
investigational new drug application, or IND, and are reviewed by the FDA prior to the commencement of human clinical trials. These preclinical data must provide an adequate basis for evaluating both the safety and the scientific rationale for the
initial trials in human volunteers.

Clinical Trials

If a company wants to test a new drug in humans, an IND must be prepared and filed with the FDA. The IND becomes effective if not rejected or put on clinical hold by the FDA within 30 days. In addition, an
Institutional Review Board comprised in part of physicians at the hospital or clinic where the proposed trials will be conducted must review and approve the trial protocol and monitor the trial on an ongoing basis. The FDA may, at any time during
the 30-day period or at any time thereafter, impose a clinical hold on proposed or ongoing clinical trials. If



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the FDA imposes a clinical hold, clinical trials cannot commence or recommence without FDA authorization and then only under terms authorized by the FDA. In
some instances, the IND application process can result in substantial delay and expense.

Clinical Trial Phases

Clinical trials typically are conducted in three sequential phases, phases I, II and III, with phase IV trials potentially conducted after marketing
approval. These phases may be compressed, may overlap or may be omitted in some circumstances.



| |  |  | Phase I clinical trials. After an IND becomes effective, phase I human clinical trials can begin. These trials evaluate a drugs safety profile, and the
range of safe dosages that can be administered to healthy volunteers and/or patients, including the maximum tolerated dose that can be given to a trial subject with the target disease or condition. Phase I trials also determine how a drug is
absorbed, distributed, metabolized and excreted by the body, and duration of its action.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase II clinical trials. Phase II clinical trials typically are designed to evaluate the potential effectiveness of the drug in patients and to further
ascertain the safety of the drug at the dosage given in a larger patient population.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase III clinical trials. In phase III clinical trials, the drug is usually tested in a controlled, randomized trial comparing the investigational new drug
to an approved form of therapy in an expanded and well defined patient population and at multiple clinical sites. The goal of these trials is to obtain definitive statistical evidence of safety and effectiveness of the investigational new drug
regime as compared to an approved standard therapy in defined patient populations with a given disease and stage of illness.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

All clinical trials for our products have been conducted in accordance with the ICH (International Conference on Harmonization) guidance so that we can apply for marketing authorization in multiple jurisdictions.

New Drug Application

After
completion of clinical trials, if there is substantial evidence that the drug is safe and effective, a new drug application, or NDA, is prepared and submitted for the FDA to review. The NDA must contain all of the essential information on the drug
gathered to that date, including data from preclinical and clinical trials, and the content and format of an NDA must conform with all FDA regulations and guidelines. Accordingly, the preparation and submission of an NDA is a major undertaking for a
company.

The FDA reviews all NDAs submitted before it accepts them for filing and may request additional information from the sponsor
rather than accepting an NDA for filing. In such an event, the NDA must be submitted with the additional information and, again, is subject to review before filing. Once the submission is accepted for filing, the FDA begins an in-depth review of the
NDA. Typically, the FDA takes ten months to review and respond to the NDA. The FDA may refer the application to an appropriate advisory committee, typically a panel of clinicians, for review, evaluation and a recommendation as to whether the
application should be approved. The FDA is not bound by the recommendation, but gives great weight to it. If the FDA evaluations of both the NDA and the manufacturing facilities are favorable, the FDA may issue either an approval letter or an
approvable letter, which usually contains a number of conditions that must be satisfied in order to secure final approval. If the FDAs evaluation of the NDA submission or manufacturing facility is not favorable, the FDA may refuse to approve
the NDA or issue a not approvable letter.

Other Regulatory Requirements

Any products we manufacture or distribute under FDA approvals are subject to pervasive and continuing regulation by the FDA, including record-keeping
requirements and reporting of adverse experiences with the products. Drug manufacturers and their subcontractors are required to register with the FDA and, where appropriate, state agencies, and are subject to periodic unannounced inspections by the
FDA and state agencies for compliance with current GMP regulations which impose procedural and documentation requirements upon us and any third party manufacturers we utilize.



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The FDA closely regulates the marketing and promotion of drugs. A company can make only those claims
relating to safety and efficacy that are approved by the FDA. Failure to comply with these requirements can result in adverse publicity, warning letters, corrective advertising and potential civil and criminal penalties. Physicians may prescribe
legally available drugs for uses that are not described in the products labeling and that differ from those tested by us and approved by the FDA. Such off-label uses are common across medical specialties. Physicians may believe that such
off-label uses are the best treatment for many patients in varied circumstances. The FDA does not regulate the behavior of physicians in their choice of treatments. The FDA does, however, restrict manufacturers communications on the subject of
off-label use.

The FDAs policies may change and additional government regulations may be enacted which could prevent or delay
regulatory approval of our product candidates or approval of new indications for our existing products. We cannot predict the likelihood, nature or extent of adverse governmental regulations that might arise from future legislative or administrative
action, either in the United States or abroad.

We received orphan drug designation for Bronchitol from the FDA in August 2005 for the
treatment of CF for patients at risk for developing bronchiectasis in the U.S. Bronchiectasis is a major risk for CF patients. Under the Orphan Drug Act, the FDA may grant orphan drug designation to drugs intended to treat a rare disease or
condition, which is generally a disease or condition that affects fewer than 200,000 individuals in the U.S. Orphan drug designation must be requested before submitting an NDA. After the FDA grants orphan drug designation, the identity of the
applicant, the therapeutic agent and the designated orphan use are disclosed publicly by the FDA. The European Medicines Agency in November 2006 has likewise granted orphan drug designation for Bronchitol in the treatment of CF in Europe.

Orphan drug designation does not convey any advantage in or shorten the duration of the regulatory review and approval process. If a
product that has orphan drug designation is the first such product to receive FDA approval for the disease for which it has such designation, the product is entitled to orphan product exclusivity, which means that the FDA may not approve any other
applications to market the same drug for the same disease, except in limited circumstances, for seven years. The FDA may permit additional companies to market a drug for the designated condition if such companies can demonstrate clinical
superiority. More than one product may also be approved by the FDA for the same orphan indication or disease as long as the products are different drugs. As a result, even if Bronchitol is approved to treat CF and receives orphan drug status, the
FDA can still approve other drugs for use in treating the same indication or disease covered by Bronchitol, which could create a more competitive market for us. Moreover, if a competitor obtains approval of the same drug for the same indication or
disease before us, we would be blocked from obtaining approval for our product for seven years, unless our product can be shown to be clinically superior.

Foreign Regulation

In addition to regulations in the U.S., we will be subject to a variety of
foreign regulations governing clinical trials and commercial sales and distribution of our products. Whether or not we obtain FDA approval for a product, we must obtain approval of a product by the comparable regulatory authorities of foreign
countries before we can commence clinical trials or marketing of the product in those countries. The approval process varies from country to country, and the time may be longer or shorter than that required for FDA approval. The requirements
governing the conduct of clinical trials, product licensing, pricing and reimbursement vary greatly from country to country.

Under E.U.
regulatory systems, marketing authorizations may be submitted either under a centralized procedure, a mutual recognition procedure or a decentralized procedure. The centralized procedure provides for the grant of a single marketing authorization
that is valid for all European Union member states. The decentralized procedure provides for a joint assessment of safety and efficacy by a number of E.U. member states. The mutual recognition procedure provides for mutual recognition of national
approval decisions. Under this procedure, the member state approving the first marketing authorization within the E.U. submits an application for recognition to other E.U. member states. Within 90 days of receipt of the application and the first
member states report of the assessment of the drug, the other member states are supposed to recognize the marketing authorization of the first member state or refer the application to the Committee for Human Medicinal Products, or CHMP, for
arbitration, if one or more member states believe there is a potential serious risk to public health, and the member states cannot reach agreement on the approval of the product. The CHMP is a scientific expert committee of the European



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Medicines Agency, or EMEA. The EMEA is responsible for the protection of public health in the E.U. through the coordination and evaluation and supervision of
medicinal products, including administering the centralized procedure and performing a more limited role in the mutual recognition procedures. After member states agree to mutual recognition of the first marketing authorization, national marketing
authorizations must still be issued in each member state which recognized it, including approval of translations, labeling and the like.

Regulation in Australia

In Australia, the relevant regulatory body responsible for the pharmaceutical industry is the
Therapeutics Goods Administration, or TGA. The TGA maintains the Australian system of controls, safety, efficacy and availability of therapeutic goods used in Australia or exported from Australia.

Any products we manufacture in Australia or distribute in, or export from, Australia are subject to pervasive and continuing regulation by the TGA. Our
products are subject to pre-market evaluation and approval by the TGA and must be entered on the Australian Register of Therapeutic Goods prior to commercial manufacture or sale. Our manufacturing facilities must be licensed by the TGA and our
products must be manufactured in accordance with international standards of Good Manufacturing Practice. The TGA carries out a range of ongoing assessment and monitoring activities, including sampling, adverse event reporting, surveillance
activities, and response to public inquiries and undertakes assessments of products for export. The TGA also regulates the advertising, labeling, product appearance and guidelines of our products.

The TGAs policies may change and additional governmental regulations may be enacted which could prevent or delay the regulatory approval of our
product candidates or approval of new indications of our existing products. We cannot predict the likelihood, nature and extent or adverse governmental regulations that might arise from future legislative or administrative action.

In addition to regulations in Europe, Australia and the United States, we will be subject to a variety of foreign regulations governing clinical trials
and commercial distribution of our products.

Employees

As of June 30, 2007, we had 58 employees, and 10 full time contractors, including 3 sales persons as well as 5 contractors within manufacturing. A total of 27 of our employees and full time contractors are
engaged in research and development, 26 are engaged in manufacturing which has a significant research component, with the remainder involved in administrative and marketing functions. Nine of our employees and full time contractors have doctoral
degrees. We believe relations with our employees are generally good. None of our employees are covered by a collective bargaining agreement.

Legal
Proceedings

We are not involved in any legal, arbitration or governmental proceedings which may have, or have had in the recent past,
significant effects on our financial position or profitability. We are also not aware of any pending legal, arbitration or governmental proceedings against us which may have significant effects on our financial position or profitability.

Research Grant Funding

We have a research grant
with the Commonwealth of Australia that assists us in funding certain of our research programs.

Under our AusIndustry P3 Pharmaceuticals
Partnerships Program funding deed with the Commonwealth of Australia, subject to certain conditions, the Commonwealth of Australia agreed to pay us a total amount of $6.1 million between the July 2004 and June 2008 for eligible
pharmaceutical research and development activities undertaken by us in relation to the development of new treatments for autoimmune diseases and the development of new treatments for chronic respiratory diseases. There was A$900,000 of grant
funding remaining as at June 30, 2007. For details regarding this research grant, see Item 10. Additional Information  C. Material Contracts  AusIndustry P3 Pharmaceuticals Partnerships Program Funding
Deed.



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|C. | Organizational Structure
|-- | ------------------------

We have one wholly owned
subsidiary, Pharmaxis Pharmaceuticals Limited, incorporated under the laws of England and Wales.



|D. | Property, Plant and Equipment
|-- | -----------------------------

As of June 30,
2007, we leased approximately 15,000 square feet of manufacturing, warehouse and office space at Unit 2, 10 Rodborough Road, Frenchs Forest, NSW 2086, Sydney, Australia. Our lease was renewed in June 2006 for a further five years, with an option to
renew for a further five years thereafter. From July 1, 2001 to June 30, 2007, we spent approximately A$4.9 million related to the establishment of this manufacturing facility.

As of June 30, 2007 we license approximately 2,000 square feet of research laboratory and office space at Building 34, 1 Rivett Road, Riverside
Corporate Park, North Ryde, Sydney, Australia. Our lease expires in June 2007.

We will require additional space and facilities as our
business expands. In particular, we will require additional manufacturing capabilities.

We have therefore recently entered into an
agreement concerning the lease of a custom designed manufacturing, warehousing and office facility of approximately 75,000 square feet. The facility is being constructed to our specifications. Once the lease commences, currently anticipated in 2H08
the lease will have a term of 15 years, with two options to renew of a further five years each and the option to break the lease at ten years but with financial penalties attached. We anticipate spending approximately A$20 million to fitout this
facility and acquire additional and expanded production equipment.

We have also recently entered into an 18 month agreement to lease
approximately 3,700 square feet of additional office space at 10 Rodborough Road, Frenchs Forest, NSW 2086, Sydney, Australia.



|4A. | Unresolved Staff Comments
|--- | -------------------------

None



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|ITEM 5. | OPERATING AND FINANCIAL REVIEW AND PROSPECTS
|------- | --------------------------------------------

The following discussion and analysis should be
read in conjunction with our financial statements and related notes included elsewhere in this report. This discussion and analysis contains forward-looking statements based upon current expectations that involve risks and uncertainties. Our actual
results and the timing of events could differ materially from those anticipated in these forward-looking statements as a result of several factors, including those set forth under Risk Factors and elsewhere in this report. Please also
see the section entitled Special Note Regarding Forward-Looking Statements. Our fiscal year ends on June 30. We designate our fiscal year by the year in which that fiscal year ends; e.g., fiscal year 2007 refers to our fiscal year
ended June 30, 2007.



|A. | Operating Results
|-- | -----------------

Overview

We are a specialist integrated pharmaceutical company involved in the research, development and commercialization of therapeutic products for chronic
respiratory and immune diseases. Research is in progress into new treatments for multiple sclerosis and respiratory diseases. We are most advanced in the development of products for asthma, cystic fibrosis and chronic obstructive pulmonary disease,
or COPD, including bronchiectasis and chronic bronchitis. At June 30, 2007, we had received marketing authorization of Aridol in Australia and Sweden and successfully completed the E.U. mutual recognition procedure allowing for the issue of
marketing authorizations in Germany, France, the United Kingdom, Italy, the Netherlands, Belgium, Denmark, Greece, Spain, Finland, Ireland, Norway and Portugal and we were in the pre-marketing application stage for Aridol in the U.S. We have three
clinical trials in progress (in patients), one project in pre-clinical evaluation (prior to being administered to volunteers or patients), and one principle research project targeting the identification of a compound for development. Our development
program has been designed to produce a series of products for large world markets over the coming years.

We were incorporated in May 1998
and in October 1999 obtained a license to a series of patents in the autoimmune area owned by the Australian National University, or ANU. We issued 11.2 million ordinary shares valued at A$1.4 million to acquire the license. Our area of focus
remained the autoimmune diseases area until October 2001 when we licensed a series of patents from the Sydney South West Area Health Service, or SSWAHS, covering new treatments for chronic lung diseases and for the measurement of lung function. Our
license with the ANU requires us to pay royalties based on sales revenue for products incorporating the licensed technology. Our current lead projects in the autoimmune area are not dependent on the technology licensed from the ANU. Our license
agreement with the SSWAHS requires us to pay royalties based on gross profit on product sales for products incorporating the licensed technology. Aridol and Bronchitol are derived from the SSWAHS license.

We have incurred net losses since our inception. We recognized a net loss of A$10.4 million, A$17.7 million and A$24.2 million in the years ended
June 30, 2005, 2006 and 2007, respectively. Our accumulated losses from inception to June 30, 2007 are A$62.8 million. We expect to incur increasing losses in the foreseeable future as we conduct clinical trials of our product candidates,
expand our organization and prepare for the commercial launch of our products upon regulatory approval.

Research and Development

Our research and development expenses consist primarily of salaries and related employee benefits, costs associated with our clinical trials,
non-clinical activities such as toxicology testing and scale-up synthesis, regulatory activities, the manufacture of material for clinical trials, development of manufacturing processes and research-related overhead expenses. Our most significant
costs are for clinical trials, preclinical development and regulatory filings. These expenses include regulatory consultants, clinical supplies and payments to external vendors such as hospitals and investigators. We expense all research and
development costs as they are incurred. We expect our research and development expenses to increase significantly in the future as we continue to move our product candidates through the development pipeline.

We classify our research and development expenses into five components:



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| | 1. | Our research unit based at the John Curtin School of Medical Research within the Australian National University, which is focused on autoimmune diseases. This unit was closed during
the year following the expansion of the Groups research unit at North Ryde.
| | -- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 2. | Our drug discovery unit based in Sydney. This unit is focused on immune disorders and respiratory drug discovery and assumed the work previously carried out at the Australian
National University.
| | -- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 3. | Our preclinical development group which is managing the outsourced safety/toxicology studies of the Aridol and Bronchitol products and the preclinical development of lead compounds
in the immune disorder area.
| | -- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 4. | Our clinical trials group, which designs and monitors our clinical trials.
| | -- | --------------------------------------------------------------------------



| | 5. | Our Australian Therapeutic Goods Administration, or TGA, registered manufacturing facility is primarily focused on producing material for clinical trials and developing enhanced
manufacturing processes. It is therefore classified as a research and development expenditure.
| | -- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Our immune disorder research
and development activities have been primarily directed at the diseases of multiple sclerosis, rheumatoid arthritis and asthma, and have explored a range of approaches. Our current immune disorder product candidate for these diseases are PXS25 and
its pro-drug PXS64. Our respiratory research and development activities have been directed at asthma, cystic fibrosis and the chronic obstructive pulmonary diseases of bronchiectasis and chronic bronchitis, and have been exclusively focused on the
development of our two current respiratory product candidates of Aridol and Bronchitol. Research and development expenses both before and after the recognition of research grants received, are presented in the following table:



|                                                                        |      |                     |        |      |                                                      |   |        |             |  |   |             |   |  |   |        |  
|----------------------------------------------------------------------- | ---- | ------------------- | ------ | ---- | ---------------------------------------------------- | - | ------ | ----------- |  | - | ----------- | - |  | - | ------ | -
|                                                                        |      | Year ended June 30, |        |      | Period from inception (May 29, 1998) toJune 30, 2007 |  
|                                                                        | 2005 |                     |        | 2006 |                                                      |   | 2007   |             | 
|                                                                        |      | A$                  |        |      | A$                                                   |   |        | A$          |  |   | A$          |  
|                                                                        |      | (in thousands)      |       
|Total research and development expenses before research grants received |      | $                   | 9,017  |      |                                                      | $ | 16,227 |             |  | $ | 23,132      |   |  | $ | 58,575 |  
|Research grants recognized against related expenses                     |      |                     | (1,132 | )    |                                                      |   | (1,245 | )           |  |   | (1,955      | ) |  |   | (7,751 | )
|                                                                        |      |                     |        |      |                                                      |   |        |             |  |   |             |   |  |   |        |  
|Net research and development                                            |      | $                   | 7,885  |      |                                                      | $ | 14,982 |             |  | $ | 21,177      |   |  | $ | 50,824 |  
|                                                                        |      |                     |        |      |                                                      |   |        |             |  |   |             |   |  |   |        |  
|                                                                        |      |                     |        |     
|                                                                        |      | (unaudited)         |        |      | (unaudited)                                          |   |        | (unaudited) |  |   | (unaudited) |  
|Autoimmune research and development                                     |      | $                   | 1,276  |      |                                                      | $ | 1,407  |             |  | $ | 1,794       |   |  | $ | 9,017  |  
|Respiratory research and development                                    |      |                     | 7,741  |      |                                                      |   | 14,820 |             |  |   | 21,338      |   |  |   | 49,558 |  
|                                                                        |      |                     |        |      |                                                      |   |        |             |  |   |             |   |  |   |        |  
|                                                                        |      | $                   | 9,017  |      |                                                      | $ | 16,227 |             |  | $ | 23,132      |   |  | $ | 58,575 |  
|                                                                        |      |                     |        |      |                                                      |   |        |             |  |   |             |   |  |   |        |  

We expect to continue to incur significant costs in the foreseeable future as we pursue these
activities. We cannot accurately forecast or reasonably estimate the additional costs that will be required to complete all of these activities, or the exact timing for their completion due to the potential failure risks and other uncertainties
inherent in the development of new drugs, such as unsuccessful clinical trials, unsuccessful development and/or commercialization and delayed regulatory approvals, amongst others. However, where the trial protocols have been finalized and
negotiations with clinical research organizations and participating trial sites are sufficiently advanced, we are able to reasonably estimate the costs (as of June 30, 2007) and timeframes (stated in calendar years unless otherwise stated) of
the next anticipated milestones described below:



| |  |  | The cost to complete our Phase II dose-ranging study of Bronchitol for cystic fibrosis is currently estimated to be approximately A$0.5 million. We commenced this
trial during the fourth quarter of 2005 and we expect to close recruitment for this trial in the second half of calendar 2007.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | The cost to complete our Phase II trial of Bronchitol with dornase alfa for cystic fibrosis is currently estimated to be approximately A$0.3 million. We commenced
enrolment of this trial during the fourth quarter of calendar 2005 and we expect to complete this trial in calendar 2007.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The cost to complete our European and Australian Phase III trial of Bronchitol for bronchiectasis is currently estimated to be approximately A$1.1 million. We
commenced this trial, the first of two planned for this indication, during the second quarter of calendar 2006 and we completed the treatment phase during the third quarter of calendar 2007.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The cost to complete our European and Australian Phase III trial of Bronchitol for cystic fibrosis is currently estimated to be approximately A$5.0 million. We
commenced this trial during the second quarter of calendar 2007 and we expect to complete recruitment for this trial in the first half of calendar 2008.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The cost to complete our Australian Phase Ib safety trial of Bronchitol for acute COPD is currently estimated to be approximately A$0.1 million. We commenced this
trial in fourth quarter calendar 2006, and expect to complete this trial in the second half of calendar 2007.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We expect
to commence our Phase III trial of Bronchitol for bronchiectasis in the U.S. during the first half of calendar 2008. We expect to commence our Phase III trial of Bronchitol for cystic fibrosis in the U.S. during the first half of calendar 2008.The
cost and timeframe to complete these trials cannot be reasonably estimated at this time.

We do not expect to complete any of the U.S.
Bronchitol research and development projects before the end of calendar 2007 and, therefore, we do not expect to receive any sales revenues in the U.S. prior to the completion of these projects. We anticipate that we will make determinations as to
which research and development projects to pursue and how much funding to direct to each project on an on-going basis in response to the scientific and clinical success of each product candidate and available funds.

Under our AusIndustry P3 Pharmaceuticals Partnerships Program funding deed with the Commonwealth of Australia, subject to certain conditions, the
Commonwealth of Australia may, as of June 30, 2007, pay us a total amount of A$0.9 million in the year to June 2008 for eligible pharmaceutical research and development activities undertaken by us in relation to the development of new
treatments for autoimmune diseases and the development of new treatments for chronic respiratory diseases. For details regarding this research grant, see Item 10. Additional Information  C. Material Contracts - AusIndustry P3
Pharmaceuticals Partnerships Program Funding Deed.

General and Administrative

General and administrative expenses consist primarily of salaries and related expenses and professional services fees and includes accounting,
administration, office and public company costs. We anticipate that general and administrative expenses will increase as a result of the expected expansion of our operations, facilities and other activities associated with the planned expansion of
our business. As an Australian listed company also listed in the U.S., we operate in an increasingly demanding regulatory environment which requires us to comply with the Sarbanes-Oxley Act of 2002 and the related rules and regulations of the
Securities and Exchange Commission, expanded disclosures, accelerated reporting requirements and complex accounting rules. Responsibilities required by the Sarbanes-Oxley Act include establishing corporate oversight and adequate internal control.

Commercial

Our commercial
expenses consist of salaries and professional fees related to the commercial launch of Aridol in Australia, Europe, the U.S. and Asia and the ongoing cost associated with the sale of Aridol. We anticipate that commercial expenses will increase as we
launch Aridol in more jurisdictions, as we prepare to launch Bronchitol, and as we incur other selling and marketing costs.



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Critical Accounting Policies and Estimates

Our managements discussion and analysis of our financial condition and results of operations are based on our financial statements which have been
prepared in accordance with accounting principles generally accepted in the U.S. The preparation of financial statements in conformity with accounting principles generally accepted in the U.S. requires management to make estimates and assumptions
that affect the reported amounts of assets and liabilities, disclosures of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Significant
management judgment is required to make estimates in relation to: the carrying value and recoverability of intangible assets; the recoverability of deferred income taxes; stock-based compensation; the accruing of liabilities for clinical and
preclinical development activities; and research development and grants. Actual results could differ from those estimates. Our significant accounting policies are more fully described in Note 3 to our financial statements appearing elsewhere in this
report. The following accounting policies are important in fully understanding and evaluating our reported financial results.

Intangible Assets

We review our capital assets, including patents and licenses, for impairment whenever events or changes in business circumstances indicate that the
carrying amount of the assets may not be fully recoverable. In performing the review, we estimate undiscounted cash flows from products under development that are covered by these patents and licenses. An impairment loss would be recognized when
estimated undiscounted future cash flows expected to result from the use of the asset and its eventual disposition is less than the carrying amount of the asset. Impairment, if any, is measured as the amount by which the carrying amount of the asset
exceeds its fair value. Impairment, if any, is assessed using discounted cash flows. Related patents are grouped in estimating future cash flows to determine whether patents are impaired and in measuring the amount of the impairment. During 2006 we
recorded an impairment charge of $109,000 in relation to an item of plant & equipment that was taken out of service, and an impairment charge of $46,000 in relation to Patent Family 6 which was allowed to lapse. No other such impairments
have been recorded since inception.

Income Taxes

We apply Statement of Financial Accounting Standards No. 109  Accounting for Income Taxes (SFAS 109) which establishes financial accounting and reporting standards for the effects of income taxes that
result from our activities during the current and preceding years. Deferred tax assets and liabilities are recognized for the future tax consequences attributable to temporary differences between the financial statement carrying amounts of assets
and liabilities and their respective tax bases. Deferred tax assets also are recognized for credit carryforwards. Deferred tax assets and liabilities are measured using the enacted rates applicable to taxable income in the years in which the
temporary differences are expected to reverse and the credits are expected to be used. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the enactment date. An assessment
is made as to whether or not it is more likely than not that deferred tax assets are recoverable. This assessment includes anticipating future taxable income and our tax planning strategies and is made on an ongoing basis. Consequently, future
material changes in the valuation allowance are possible.

Stock-Based Compensation

We account for stock-based employee compensation arrangements using the fair value based method as prescribed in accordance with the provisions of
Statement of Financial Accounting Standards No. 123(R)  Accounting for Stock-Based Compensation (SFAS 123(R)). The terms of option grants are determined by our Board. Options are generally granted for nil monetary consideration and
have a life of ten years. Options granted to executives and employees generally vest equally over a four year period. For options granted after January 1, 2003, the annual vesting for executives and employees is subject to approval by the
Remuneration and Nomination Committee of the Board. The Committee gives its approval for vesting based on the achievement of individual employees personal annual objectives. In accordance with SFAS 123(R), the fair values of the option grants
are estimated on the date of each grant using the Black-Scholes option pricing model, which requires the use of certain significant assumptions. Changes to these assumptions, which include volatility, risk free interest rate, dividend yield,
expected life, exercise price and the market price, could cause a material difference in the fair value of the options and the amount of compensation expense recognized. Annual option grants to non executive directors after June 30, 2007 vest
immediately on the latter of grant or shareholder approval.



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Research and Development Grants

We receive grant funding under government research grant agreements to undertake work on the applicable grant projects, including the purchase of plant
and equipment. In order to receive the grant funding, our existing grant agreements require us to incur specified eligible expenditure in the conduct of the applicable grant project. There are circumstances where grant funding may not be payable and
there are certain limited circumstances, such as when we fail to use our best endeavors to commercialize the project within a reasonable time of completion of the project or upon termination of a grant due to our breach of the agreement or our
insolvency, where we may be required to repay some or all of the research grants. Grants in relation to expenditure are recognized against the related research and development expenses as and when the relevant research expenditure is incurred.
Grants related to plant and equipment are recognized against the acquisition costs of the related plant and equipment as and when the related assets are purchased. Grants received in advance of incurring the relevant expenditure are treated as
deferred research grants and included in Other Accrued Liabilities on the balance sheet as we do not control the monies until the relevant expenditure has been incurred.

Results of Operations

Comparison of fiscal years ended June 30, 2006 and June 30, 2007

Sales and Gross Profit.Sales were A$0.008 million in fiscal 2006 compared to A$0.2 million in fiscal 2007. Our first product Aridol was
launched in Australia in June 2006 and was approved for sale in Sweden in October 2006 and the E.U. mutual recognition procedure was successfully completed in June 2007 allowing for the issue of marketing authorizations in Germany, France, the
United Kingdom, Italy, the Netherlands, Belgium, Denmark, Greece, Spain, Finland, Ireland, Norway and Portugal. Approximately 60 percent of sales for the fiscal 2007 were in Australia. The other 40 percent of sales were split approximately evenly
between Sweden and a U.S. biopharmaceutical company which is using Aridol in clinical trials. Gross profit was approximately 75 percent of sales in both years.

Research and Development Expenses.Research and development expenses for fiscal 2006 and 2007, respectively, are shown in the table below net of research grants received.



|                                        |  |                      |        |   |      |   |        |  
|--------------------------------------- |  | -------------------- | ------ | - | ---- | - | ------ | -
|                                        |  | Years ended June 30, |       
|                                        |  | 2006                 |        |   | 2007 |  
|                                        |  | A$                   |        |   | A$   |  
|                                        |  | (in thousands)       |       
|Total research and development expenses |  | $                    | 16,227 |   |      | $ | 23,132 |  
|Related research grants                 |  |                      | (1,245 | ) |      |   | (1,955 | )
|                                        |  |                      |        |   |      |   |        |  
|Net research and development expenses   |  | $                    | 14,982 |   |      | $ | 21,177 |  
|                                        |  |                      |        |   |      |   |        |  

Grant revenue in fiscal 2007 relates exclusively to an Australian Government Pharmaceuticals Partnerships Program
grant (P3 Grant) awarded to us in June 2004. Grant revenue in fiscal 2006 relates to an Australian Government R&D Start Grant (Start Grant) awarded to us in June 2003 to develop new treatments for cystic fibrosis and the
P3 Grant. The Start Grant was payable based on underlying expenditure on the research project, makes up approximately 35% of the total research grants received during fiscal 2006 and was completed on December 31, 2005. There are certain limited
circumstances where we may be required to repay grant funding. The P3 Grant payable to us is 30% of the increase of eligible research and development expenditure over a base level of expenditure.

Total research and development expenses increased from A$16.2 million in fiscal 2006 to A$23.1 million in fiscal 2007. There are five components to the research and
development expenses:



| | 1. | Our research unit based at the John Curtin School of Medical Research within the Australian National University. This unit was closed during the year following the expansion of our
research unit in Sydney. The unit accounted for approximately 1 percent of our total research and development expenditure in the current year. The research unit was focused on immune disorders. The level of expenditure in fiscal 2007 decreased by
approximately A$0.5 million, compared to fiscal 2006.
| | -- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

| | 2. | Our drug discovery group based in leased laboratories in Sydney accounted for approximately 5 percent of our total research and development expenditure in the current year and
increased by approximately 157 percent or A$0.8 million compared to fiscal 2006. This unit is focused on immune disorders and respiratory drug discovery and assumed the work previously carried out at the Australian National University. This area of
research accounted for approximately 12 percent of the increase in overall research and development expenditure during fiscal 2007.
| | -- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 3. | Our preclinical development group accounted for approximately 10 percent of our total research and development expenditure in the current fiscal year and increased by approximately
20 percent or A$0.4 million compared to fiscal 2006. This group is managing the outsourced safety/toxicology studies of the Aridol and Bronchitol products and the preclinical development of lead compounds in the immune disorder area (PXS25 and its
pro-drug PXS64). Approximately 90 percent of expenditure in fiscal 2007 related to the Aridol and Bronchitol studies. This area of research accounted for approximately 6 percent of the increase in overall research and development expenditure
during fiscal 2007.
| | -- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 4. | Our clinical group located at our Frenchs Forest facility accounted for approximately 58 percent of our total research and development expenditure in fiscal 2007 and increased by
approximately 34 percent or A$3.4 million compared to fiscal 2006. The clinical group designs and monitors the clinical trials run by us. The majority of the expenditures of this group are directed at hospitals and other services related to the
conduct and analysis of clinical trials. This significant increase in expenditure reflects the number and size of clinical trials ongoing during fiscal 2007. This area of research accounted for approximately 50 percent of the increase in overall
research and development expenditure during fiscal 2007.
| | -- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 5. | Our TGA registered manufacturing facility at Frenchs Forest is predominantly focused on producing material for clinical trials and developing enhanced manufacturing processes.
Manufacturing expenses for the current year have therefore mainly been classified as a research and development expenditure. Manufacturing accounted for approximately 21 percent of our total research and development expenditure in fiscal 2007 and
increased by approximately 84 percent or A$2.7 million compared to fiscal 2006, reflecting manufacturing performance/yield innovation and product stability studies required to support registration applications. This area of expenditure
accounted for approximately 40 percent of the increase in overall research and development expenditure during fiscal 2007.
| | -- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

General and Administrative Expenses.General and administrative expenses were A$4.0 million in both fiscal 2006 and fiscal 2007.

Commercial expenses. Commercial expenses were A$1.8 in fiscal 2006 compared to A$2.8 million in fiscal 2007. The commercial launch of Aridol in Australia and preparation for the full commercial launch in Europe resulted in additional
one time expenses over and above the first full year of costs associated with the hiring of a sales and marketing team in Australia and Europe late in fiscal 2006. In addition costs were incurred obtaining detailed global market information in
relation to bronchiectasis.

Stock Compensation Expenses.Stock compensation expenses increased from A$1.1 million in fiscal 2006 to
A$1.5 million in fiscal 2007, reflecting a grant of options to all employees in August 2005 and again in August 2006, as well as an increase in employee numbers, all of whom are eligible for options.

Interest and Other Income and Expense.Interest and other income increased from A$4.3 million in fiscal 2006 to A$5.3 million in fiscal 2007. The
increase in interest income is attributable to the greater level of funds invested during fiscal 2007. We started fiscal 2007 with $98 million of cash and bank accepted bills of exchange. By contrast we started fiscal 2006 with $33 million of cash
and bank accepted bills of exchange, to which was added approximately $80 million in November 2005 from the capital raising undertaken in Australia and the United States.

Income Tax Expense.The Company recorded an income tax expense for the first time in fiscal 2006 and again in fiscal 2007. The expense relates to income generated by the Companys UK subsidiary which is
currently reimbursed for its expenditures on a cost plus basis upon which tax is payable.



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##### Table of Contents

Net Loss.Net loss increased from A$17.7 million in fiscal 2006 to A$24.2 million in fiscal 2007.
The significant increase in operating expenses discussed above was only partly offset by the increase in interest and other income.

Basic and diluted net loss per share.Basic and diluted net loss per share increased from A$0.11 in fiscal 2006 to A$0.14 in fiscal 2007 predominantly because of the increase in research and development expenses in 2007.

Comparison of fiscal years ended June 30, 2005 and June 30, 2006

Research and Development Expenses.Research and development expenses for fiscal 2005 and 2006, respectively, are shown in the table below net of research grants received.



|                                        |  |                      |        |   |      |   |        |  
|--------------------------------------- |  | -------------------- | ------ | - | ---- | - | ------ | -
|                                        |  | Years ended June 30, |       
|                                        |  | 2005                 |        |   | 2006 |  
|                                        |  | A$                   |        |   | A$   |  
|                                        |  | (in thousands)       |       
|Total research and development expenses |  | $                    | 9,017  |   |      | $ | 16,227 |  
|Related research grants                 |  |                      | (1,132 | ) |      |   | (1,245 | )
|                                        |  |                      |        |   |      |   |        |  
|Net research and development expenses   |  | $                    | 7,885  |   |      | $ | 14,982 |  
|                                        |  |                      |        |   |      |   |        |  

Grant revenue in fiscal 2005 relates exclusively to an Australian Government R&D Start Grant (Start
Grant) awarded to us in June 2003 to develop new treatments for cystic fibrosis. Grant revenue in fiscal 2006 relates to both the Start Grant and an Australian Government Pharmaceuticals Partnerships Program grant (P3 Grant)
awarded to us in June 2004. The Start Grant is payable based on underlying expenditure on the research project, and makes up approximately 35% of the total research grants received during fiscal 2006. The Start Grant was completed on
December 31, 2005. There are certain limited circumstances where we may be required to repay grant funding. The P3 Grant payable to Pharmaxis is 30% of the increase of eligible research and development expenditure over a base level of
expenditure. The P3 Grant accounted for approximately 65% of the total research grants received during fiscal 2006.

Total research and development
expenses increased from A$9.0 million in fiscal 2005 to A$16.2 million in fiscal 2006. There are five components to the research and development expenses:



| | 1. | Our research unit based at the John Curtin School of Medical Research within the Australian National University accounted for approximately 5 percent of our total research and
development expenditure in the current year. The research unit is focused on immune disorders. The level of expenditure in fiscal 2006 increased by approximately 6 percent or A$0.05 million, compared to fiscal 2005.
| | -- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 2. | Our drug discovery group based in leased laboratories at Sydney accounted for approximately 2 percent of our total research and development expenditure in the current year. This
unit is focused on immune disorders and respiratory drug discovery and is complementary to the work carried out at the Australian National University.
| | -- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 3. | Our preclinical development group located at our Frenchs Forest facility accounted for approximately 12 percent of our total research and development expenditure in the current
fiscal year and increased by approximately 35 percent or A$0.5 million compared to fiscal 2005. This group is managing the outsourced safety/toxicology studies of the Aridol and Bronchitol products and the preclinical development of lead compounds
in the immune disorder area (PXS25 and its pro-drug PXS64). Approximately 90 percent of expenditure in fiscal 2006 related to the Aridol and Bronchitol studies. This area of research accounted for approximately 7 percent or A$0.5 million of the
increase in overall research and development expenditure during fiscal 2006.
| | -- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 4. | Our clinical group located at our Frenchs Forest facility accounted for approximately 61 percent of our total research and development expenditure in fiscal 2006
and increased by approximately 218 percent or A$5.4 million compared to fiscal 2005. The clinical group designs and monitors the clinical trials run by us. The majority of the expenditures of this group are directed at hospitals and other services
related to the conduct and analysis of clinical trials. This significant increase in expenditure reflects the number
| | -- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

| | and size of clinical trials ongoing during fiscal 2006. This area of research accounted for approximately 75 percent or A$5.4 million of the increase in
overall research and development expenditure during fiscal 2005.
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 5. | Our TGA registered manufacturing facility at Frenchs Forest. Before the change of its TGA licence in April 2006 to allow for commercial manufacture, this facility was totally
focused on producing material for clinical trials and developing enhanced manufacturing processes. Manufacturing expenses for the current year have therefore mainly been classified as a research and development expenditure. Manufacturing accounted
for approximately 20 percent of our total research and development expenditure in fiscal 2006 and increased by approximately 41 percent or A$0.9 million compared to fiscal 2005, reflecting manufacturing performance/yield innovation and product
stability studies required to support registration applications. This area of expenditure accounted for approximately 13 percent or A$0.9 million of the increase in overall research and development expenditure during fiscal 2006.
| | -- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

General and Administrative Expenses.General and administrative expenses increased from A$3.1 million in fiscal 2005
to A$4.0 million in fiscal 2006. The increase in expenses of A$1 million reflects growth in the size and complexity of the Groups operations, as well as the incremental costs of being listed on both the Australian Securities Exchange and
Nasdaq Global Market.

Commercial expenses. Commercial expenses were A$0.8 in fiscal 2005 compared to A$1.8 million in fiscal 2006.
The commercial launch of Aridol was a significant cause of the increased level of expenses involving the hiring of a sales and marketing manager and a sales team of five, and the state by state presentations of Aridol to the respiratory communities.
The creation of a European Pharmaxis operation also added to commercial expenses in the year. The operation, based in the United Kingdom and employing two people, is required to coordinate and manage the marketing/distribution partners we have and
are appointing to market, sell and distribute Aridol throughout Europe.

Stock Compensation Expenses.Stock compensation expenses
increased from A$0.3 million in fiscal 2005 to A$1.1 million in fiscal 2006, reflecting a grant of options to all employees in August 2005, as well as an increase in employee numbers, all of whom are eligible for options.

Interest and Other Income and Expense.Interest and other income increased from A$1.7 million in fiscal 2005 to A$4.3 million in fiscal 2006. We
started fiscal 2006 with A$33.3 million of cash and cash equivalents on which interest was earned. This was increased by A$80 million as a result of our U.S. public offering and concurrent Australian share placement which completed in November 2005.
By contrast, we started fiscal 2005 with A$25.1 million of cash and cash equivalents on which interest was earned which increased by A$19 million due to our private placement and share purchase plan in November and December 2004. The increase in
interest income, while mainly attributable to the greater level of funds invested during the year, was to a lesser extent the result of a slightly higher prevailing interest rate in fiscal 2006.

Income Tax Expense.The Company recorded an income tax expense for the first time in fiscal 2006. The expense relates to income generated by the
Companys UK subsidiary which is currently reimbursed for its expenditures on a cost plus basis upon which tax is payable.

Net Loss.Net loss increased from A$10.4 million in fiscal 2005 to A$17.7 million in fiscal 2006. The significant increase in operating expenses discussed above was only partly offset by the increase in interest and other income.

Basic and diluted net loss per share.Basic and diluted net loss per share increased from A$0.08 in fiscal 2005 to A$0.11 in fiscal
2006 predominantly because of the increase in research and development expenses in 2006.



|B. | Liquidity and Capital Resources
|-- | -------------------------------

Liquidity and Capital Resources



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##### Table of Contents

Since our inception, our operations have mainly been financed through the issuance of equity securities
and convertible redeemable preference shares. Additional funding has come through research grants, interest on investments, the exercise of options and rent received from a former subtenant. Through June 30, 2007, we had received net cash
proceeds from the following: (a) A$122.3 million from the issuance of ordinary shares; (b) A$11.4 million from the issuance of convertible redeemable preference shares; and (c) approximately A$8.0 million in research grants. We have
incurred significant losses since our inception. We incurred losses of A$10.4 million, A$17.7 million and A$24.2 million and A$62.8 million in fiscal 2005, 2006, 2007 and since inception to June 30, 2007, respectively. As of June 30, 2007
we had cash and cash equivalents of A$76.2 million and additionally have ongoing research grants with a total of A$0.9 million of funding potentially available.

For fiscal 2007, we used net cash of A$20.7 million for operating activities. This consisted of a net loss for the period of A$24.2 million, which included A$0.9 million of non-cash depreciation and amortization, and
non-cash stock option expense of A$1.5 million, and other working capital movements of A$1.0 million. Net cash used in investing activities during fiscal 2007 was A$1.3 million, which included purchase of plant and equipment for quality control
laboratory facilities and equipment. Net cash provided by financing activities during fiscal 2007 was A$0.3 million resulting from the issue of shares upon the exercise of options granted under the Pharmaxis Employee Option Plan.

For fiscal 2006, we used net cash of A$13.7 million for operating activities. This consisted of a net loss for the period of A$17.7 million, which
included A$0.9 million of non-cash depreciation and amortization, and non-cash stock option expense of A$1.1 million, and other working capital movements of A$2.0 million. Net cash used in investing activities during fiscal 2006 was A$1.8 million,
which included purchase of plant and equipment for manufacturing expansion. Net cash provided by financing activities during fiscal 2006 was A$80.0 million resulting from the issue and sale of our ordinary shares in a U.S. public offering and a
concurrent Australian share placement.

For fiscal 2005, we used net cash of A$9.3 million for operating activities. This consisted of a
net loss for the period of A$10.4 million, which included A$0.6 million of non-cash depreciation and amortization, and non-cash stock option expense of A$0.3 million, and other working capital movements of A$0.3 million. Net cash used in investing
activities during fiscal 2005 was A$1.6 million, which included purchase of plant and equipment of A$1.3 million reflecting the manufacturing expansion. Net cash provided by financing activities during fiscal 2005 was A$19.0 million resulting from
the issue and sale of our ordinary shares in a share placement to Australian qualified institutional and sophisticated investors, and a share purchase plan available to existing shareholders.

At June 30, 2007, we had cash and cash equivalents of A$76.2 million as compared to A$97.8 million as of June 30, 2006. This overall decrease
was primarily due to our research and development program.

On October 11, 2007 the Company announced a A$50 million placement to
institutions and sophisticated investors at A$3.90 per share. At the same time the Company announced a share purchase plan whereby each shareholder could subscribe for up to A$5,000 worth of Pharmaxis Ltd shares at an issue price of A$3.90. The
share purchase plan closed on November 9, 2007 and raised A$11.7 million.

We believe that our cash and cash equivalents will be
sufficient to meet our capital requirements for at least the next 12 months. However, our forecast of the period of time through which our financial resources will be adequate to support our operations is a forward-looking statement that involves
risks and uncertainties, and actual results could vary materially. If we are unable to raise additional capital when required or on acceptable terms, we may have to significantly delay, scale back or discontinue one or more of our clinical trials or
our operations.

We expect to continue to incur substantial losses. Our future capital requirements are difficult to forecast and will
depend on many factors, including:



| |  |  | the costs of expanding sales, marketing and distribution capabilities;
| | - |  | ----------------------------------------------------------------------



| |  |  | the scope, results and timing of preclinical studies and clinical trials;
| | - |  | -------------------------------------------------------------------------



| |  |  | the costs and timing of regulatory approvals; and
| | - |  | -------------------------------------------------



| |  |  | the cost of filing, prosecuting, defending and enforcing any patent claims and other intellectual property rights.
| | - |  | ------------------------------------------------------------------------------------------------------------------

We anticipate that a substantial portion of our capital resources and efforts in the foreseeable future will be focused on finding:



| |  |  | the clinical development for Bronchitol in patients with cystic fibrosis;
| | - |  | -------------------------------------------------------------------------



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| |  |  | the commercial launch of Aridol for the management of asthma in the E.U. and the U.S.;
| | - |  | --------------------------------------------------------------------------------------



| |  |  | the clinical development of Aridol for management of asthma and COPD;
| | - |  | ---------------------------------------------------------------------



| |  |  | the clinical development for Bronchitol in patients with bronchiectasis and chronic bronchitis;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | the pre-clinical development of our product pipeline; and
| | - |  | ---------------------------------------------------------



| |  |  | further expansion of our manufacturing capablities.
| | - |  | ---------------------------------------------------

Quantitative and Qualitative Disclosures about Market Risk

Our exposure to market risk is limited to interest income
sensitivity, which is affected by changes in the general level of Australian interest rates, particularly because the majority of our investments are in cash and cash equivalents. The primary objective of our investment activities is to preserve
principal while at the same time maximizing the income we receive without significantly increasing risk. Our investment portfolio is subject to interest rate risk and will fall in value in the event market interest rates increase. Due to the short
duration of our investment portfolio, we believe an immediate 10% change in interest rates would not be material to our financial condition or results of operations. We do not have derivative financial instruments.

Income Taxes

As of June 30, 2007, we had net
operating loss carry forwards of A$79.2 million (A$47.9 million as of June 30, 2006). While these losses do not expire, our utilization will depend upon our ability to derive future taxable income of a nature and of an amount sufficient to
enable the deduction for the losses to be realized, our continued compliance with the conditions for deductibility imposed by tax legislation, and the absence of changes in tax legislation that adversely affect our ability to utilize the loss.

As of June 30, 2006 and 2007, we did not record a benefit for the deferred tax assets because realization of the deferred tax assets
was not more likely than not and, accordingly, a valuation allowance is provided to completely offset the deferred tax assets.

Recently Issued
Accounting Announcements

In June 2006, the FASB issued FASB Interpretation No. 48 (FIN 48), Accounting for Uncertainty in
Income Taxesan interpretation of FASB Statement No. 109, Accounting for Income Taxes, which clarifies the accounting for uncertainty in income taxes. FIN 48 prescribes a recognition threshold and measurement attribute for the
financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. The Interpretation requires that the Company recognize in the financial statements, the impact of a tax position, if that position is
more likely than not of being sustained on audit, based on the technical merits of the position. FIN 48 also provides guidance on derecognition, classification, interest and penalties, accounting in interim periods and disclosure. The provisions of
FIN 48 are effective for the first fiscal year beginning after December 15, 2006 with the cumulative effect of the change in accounting principle recorded as an adjustment to opening retained earnings. We are currently evaluating the possible
impact of FIN 48 on our consolidated financial statements which we will adopt as of July 1, 2007.

In September 2006, the FASB issued
Statement of Financial Accounting Standards No. 157, Fair Value Measurements (SFAS No. 157). This Statement defines fair value as used in numerous accounting pronouncements, establishes a framework for measuring fair value in
generally accepted accounting principles (GAAP) and expands disclosure related to the use of fair value measures in financial statements. SFAS No. 157 does not expand the use of fair value measures in financial statements, but standardizes its
definition and guidance in GAAP. The Standard emphasizes that fair value is a market-based measurement and not an entity-specific measurement based on an exchange transaction in which the entity sells an asset or transfers a liability (exit price).
SFAS No. 157 establishes a fair value hierarchy from observable market data as the highest level to fair value based on an entitys own fair value assumptions as the lowest level. The Statement is to be effective for our financial
statements issued in 2008; however, earlier application is encouraged. We believe that SFAS No. 157 will not have a material impact on our consolidated financial statements.



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|C. | Research and development, patents and licenses, etc.
|-- | ----------------------------------------------------

See Item 5A  Operating Results  Research and Development.



|D. | Trend Information
|-- | -----------------

See Item 5A 
Operating Results and Item 5B  Liquidity and Capital Resources.



|E. | Off-Balance Sheet Arrangements
|-- | ------------------------------

We have no
off-balance sheet arrangements that have or are reasonably likely to have a current or future effect on our financial condition, changes in financial condition, revenues or expenses, results of operations, liquidity, capital expenditures or capital
resources that are material to investors.



|F. | Contractual Obligations and Commitments
|-- | ---------------------------------------

The
following table summarizes financial data for our contractual obligations and other commercial commitments, including interest obligations, as of June 30, 2007 (in thousands):



|                                                                                                              |  |                        |       |                 |   |             |  |             |       |                  |   |   |  |   |  
|------------------------------------------------------------------------------------------------------------- |  | ---------------------- | ----- | --------------- | - | ----------- |  | ----------- | ----- | ---------------- | - | - |  | - | -
|                                                                                                              |  | Payments due by Period
|Contractual Obligations                                                                                       |  | Total                  |       | Less than1 year |   | 1 - 3 years |  | 3 - 5 years |       | More than5 years
|                                                                                                              |  | A$                     |       | A$              |   | A$          |  | A$          |       | A$              
|Long-Term Debt Obligations                                                                                    |  |                        |      |                 | $ |            |  | $           |      |                  | $ |  |  | $ | 
|Capital (Finance) Lease Obligations                                                                           |  |                        |      |                 |   |            |  |             |      |                  |   |  |  |   | 
|Operating Lease Obligations                                                                                   |  |                        | 1,472 |                 |   | 401         |  |             | 1,071 |                  |   |  |  |   | 
|Purchase Obligations                                                                                          |  |                        |      |                 |   |            |  |             |      |                  |   |  |  |   | 
|Other Long-Term Liabilities Reflected on our Balance Sheet under the GAAP of the primary financial statements |  |                        |      |                 |   |            |  |             |      |                  |   |  |  |   | 
|                                                                                                              |  |                        |       |                 |   |             |  |             |       |                  |   |   |  |   |  
|Total                                                                                                         |  | $                      | 1,472 |                 | $ | 401         |  | $           | 1,071 |                  | $ |  |  | $ | 
|                                                                                                              |  |                        |       |                 |   |             |  |             |       |                  |   |   |  |   |  

The contractual summary above reflects only payment obligations that are fixed and determinable. We have
additional contractual payment obligations that are contingent on future events. Our operating lease obligations primarily relate to the lease for our headquarters in Frenchs Forest. We also have agreements with clinical sites, and contract research
organizations, for the conduct of our clinical trials and other research activities.



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|ITEM 6. | DIRECTORS, SENIOR MANAGEMENT AND EMPLOYEES
|------- | ------------------------------------------

Management



|A. | Directors and Senior Management
|-- | -------------------------------

The following table presents
information about our executive officers and directors as of September 30, 2007.



|                               |  |     |  |                                              
|------------------------------ |  | --- |  | ---------------------------------------------
|Name                           |  | Age |  | Position                                     
|Alan D. Robertson, Ph.D.       |  | 51  |  | Chief Executive Officer and Managing Director
|Brett Charlton, Ph.D.          |  | 51  |  | Medical Director                             
|John F. Crapper                |  | 55  |  | Chief Operations Officer                     
|Ian A. McDonald, Ph.D.         |  | 60  |  | Chief Scientific Officer                     
|David M. McGarvey              |  | 51  |  | Chief Financial Officer and Company Secretary
|Gary J. Phillips               |  | 46  |  | Head of Commercial Development               
|Denis M. Hanley(1)(2)          |  | 60  |  | Chairman of the Board                        
|Peter C. Farrell, Ph.D. DSc(2) |  | 65  |  | Director                                     
|Charles P.H. Kiefel(1)         |  | 52  |  | Director                                     
|Malcolm J. McComas(1)          |  | 53  |  | Director                                     
|John Villiger, Ph.D.(2)        |  | 53  |  | Director                                     

---

|(1) | Member of the Audit Committee.
|--- | ------------------------------



|(2) | Member of the Remuneration and Nomination Committee.
|--- | ----------------------------------------------------

The business
address for our executive officers and directors is c/o Pharmaxis Ltd, Unit 2, 10 Rodborough Road, Frenchs Forest, NSW Australia 2086.

Executive
Officers and Directors

Alan D. Robertson, Ph.D., has been our Chief Executive Officer since December 1999 and a member of our
board of directors since July 2000. Dr. Robertson has more than two decades of experience in drug discovery and product development with leading pharmaceutical companies, including spending 8 years with Wellcome plc in London and thereafter
with two Australian companies, Faulding Ltd and Amrad Ltd. Dr. Robertson has been actively involved in the discovery, development and marketing of various compounds, including new treatments for migraine and cardiovascular disease.
Dr. Robertson is the co-inventor of 18 patents and author of more than 35 scientific papers, and was the inventor of the migraine therapeutic Zomig that is marketed worldwide by AstraZeneca. Dr. Robertson holds a B.Sc. and a Ph.D. in
Synthetic Organic Chemistry from the University of Glasgow.

Brett Charlton, Ph.D., is a co-founder of Pharmaxis and has been our
Medical Director and was a member of our board of directors from June 1998 to March 2006. Dr. Charlton is the author of more than 60 scientific papers and has over 15 years of experience in clinical trial design and management.
Dr. Charlton was founding Medical Director of the National Health Sciences Centre and established its Clinical Trials Unit. Prior to joining us, Dr. Charlton held various positions with the Australian National University, Stanford
University, the Baxter Centre for Medical Research, Royal Melbourne Hospital, and the Walter and Eliza Hall Institute. Dr. Charlton holds a M.B.B.S. with honors from the University of New South Wales and a Ph.D. from the University of New South
Wales.

John F. Crapperhas been our Chief Operations Officer since July 2003. Mr. Crapper has over three decades of experience
in manufacturing and operations. From 1987 to 2003, Mr. Crapper held various positions within the Memtec Limited/Memcor organization most recently as Senior Vice-President and General Manager of Memcor International, and Managing Director of
Memcor Australia Pty Ltd, a leader in the design and manufacture



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of microfiltration membranes and systems. During his 15 years at Memcor, Mr. Crapper managed the scale-up of manufacturing equipment and processes from
the companys research and development group, created full-scale production operations, and managed the establishment of Quality Assurance and Enterprise Resource Planning systems. From 1980 to 1987, Mr. Crapper served as Operations
Director of the Animal Health Division at Syntex Pharmaceutical. From 1971 to 1980, Mr. Crapper served as Production Manager at VR Laboratories, a private veterinary pharmaceutical company. Mr. Crapper holds a B.S. in Applied Chemistry
from the University of Technology, Sydney and an M.B.A from Macquarie University.

Ian A. McDonald, Ph.D., has been our Chief
Scientific Officer since September 2006, having previously served as Chief Technical Officer from his joining us in April 2005. Dr. McDonald has over 25 years of experience in managing drug discovery and design teams in Europe and the U.S. From
2002 to 2004, Dr. McDonald served as Vice President of Drug Discovery at Structural GenomiX, Inc. (now SGX Pharmaceuticals Inc.). From 2001 to 2002, Dr. McDonald served as Vice President of Drug Discovery at Structural Bioinformatics Inc.
(now Cengent Therapeutics). From 1993 to 2000, Dr. McDonald served as Director, then Vice President of Chemistry at SIBIA Neuroscience (now part of Merck Research Laboratories) and was responsible for medicinal and bio-chemistry research. From
1978 to 1993, Dr. McDonald served in various capacities as a research chemist at Merrell Dow (now part of Sanofi-Aventis). Dr. McDonald is the co-inventor of 39 U.S. patents and co-author of 77 peer-reviewed manuscripts and book chapters.
Dr. McDonald holds B.S. and Ph.D. degrees in Organic Chemistry from the University of Western Australia.

David M. McGarvey, C.A.,
C.P.A., has been our Chief Financial Officer and Company Secretary since December 2002. Mr. McGarvey has two decades of experience in overseeing the financial affairs of different Australian companies. From 1998 to 2002, Mr. McGarvey
served as Chief Financial Officer of the Filtration and Separations Group of U.S. Filter Corporation where he managed over 20 merger and acquisition transactions, including the sale of the Filtration and Separations Group to Pall Corporation in
2002. From 1985 to 1997, Mr. McGarvey served as Chief Financial Officer of Memtec Limited. While at Memtec, Mr. McGarvey oversaw the U.S. listing of Memtec on the Nasdaq Global Market and the New York Stock Exchange and managed over 10
merger and acquisition transactions, including the acquisition of Memtec by U.S. Filter. From 1975 to 1985, Mr. McGarvey held various positions at PricewaterhouseCoopers. Mr. McGarvey holds a B.A. in Accounting from Macquarie University
and was admitted to the Institute of Chartered Accountants in Australia in 1981, and to the membership of CPA Australia in 1993.

Gary
J. Phillipshas been our Head of Commercial Development since December 2003. Mr. Phillips has over two decades of operational management experience in the pharmaceutical and healthcare industry in Europe, Asia and Australia. From 1998 to
2003, Mr. Phillips held various positions within Novartis Asia, most recently as Chief Executive Officer of Novartis Pharmaceuticals Australia Pty Ltd, where he successfully launched leading oncology and ophthalmology products and relaunched
newly acquired primary care products. From 1992 to 1998, Mr. Phillips served as Chief Executive Officer at Ciba Geigy in Hungary. Mr. Phillips holds a B. Pharm. in Pharmacy with honors from Nottingham University in the U.K. and an M.B.A.
from Henly Management College.

Denis M. Hanleyhas been the Chairman of our board of directors since October 2001. From 1983 to
1997, Mr. Hanley served as Chief Executive Officer of Memtec Limited, a leader in the design and manufacture of microfiltration membrane systems. From 1971 to 1982, Mr. Hanley held various positions within Baxter Healthcare, most recently
as Australian Managing Director. Mr. Hanley has served on the Australian Industry Research and Development Board and various technology councils and roundtables. Mr. Hanley serves on the board of directors of Lochard Limited, Universal
Biosensors, Inc., CathRx Ltd and PFM Cornerstone Limited, and was a member of the Australian Governments Cooperative Research Centre Committee. Mr. Hanley holds an M.B.A. with high distinction from the Harvard Graduate School of Business
Administration, where he was named a Baker Scholar.

Peter C. Farrell, Ph.D.,has been a member of our board of directors since
March 2006. Dr. Farrell has more than two decades of experience in developing and commercialising medical products in the U.S., Europe, Japan and Australia. Dr. Farrell began his commercial career with Baxter Healthcare, Inc. in Japan as
Director and Vice President of Research and Development, then as Managing Director of the Baxter Center for Medical Research. He left Baxter in 1989 to establish ResMed, Inc., a company that develops treatments for sleep-disordered breathing
and respiratory failure. Dr. Farrell is currently founding Chairman and Chief Executive Officer of ResMed Inc. Dr. Farrell serves on the Executive Councils of Harvard Medical School and the University of California at San Diego, and
is visiting Professor at the University of Sydney. Dr. Farrell has written more than 150



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papers covering topics from engineering applications in medicine to focusing technology to meet business objectives. Dr. Farrell holds bachelor and
masters degrees in chemical engineering from the University of Sydney and the Massachusetts Institute of Technology, a Ph.D. in bioengineering from the University of Washington, Seattle and a Doctor of Science from the University of New South Wales
for research related to dialysis and renal medicine.

Charles P.H. Kiefelhas been a member of our board of directors since May
2003. Mr. Kiefel has more than two decades of experience in finance and investment banking and funds management. Mr. Kiefel is currently an advisory board member of two of Australias largest private equity funds and the director of
business development for two major U.S. money managers. From 1990 to 2000, Mr. Kiefel was Managing Director of Corporate Finance at ANZ Investment Bank. From 1986 to 1990, Mr. Kiefel was Director of Corporate Finance at Ord Minnett. From
1985 to 1986, Mr. Kiefel held positions at Lazard Brothers & Co. Ltd in the U.K. and Lazard Freres in New York. Mr. Kiefel serves on the board of directors of Wilson HTM Charities Ltd, Universal Biosensors, Inc. and PFM
Cornerstone Limited,. Mr. Kiefel has a B. Com. from the University of New South Wales and is a Fellow of the Institute of Chartered Accountants in Australia.

Malcolm J. McComashas been a member of our board of directors since July 2003. Mr. McComas has more than two decades of experience in investment banking, particularly in equity and debt finance, mergers
and acquisitions, and privatizations. From 1999 to 2004, Mr. McComas was a director of Grant Samuel and currently serves as a consultant to their corporate advisory, property services and funds management group. During 1998, Mr. McComas
served as a Managing Director at Salomon Smith Barney. From 1988 to 1997, Mr. McComas served as a Managing Director at County NatWest. Mr. McComas serves as a non-executive director of Australasian Investors Limited and non-executive
chairman of Sunshine Heart Inc. Mr. McComas holds a Bachelor of Economics and a Bachelor of Laws from Monash University.

John
Villiger, Ph.D was appointed a member of our board of directors on November 15, 2006. Dr. Villiger co-founded The Medicines Company, a Nasdaq listed company in 1996. Dr. Villiger was Senior Vice President of Development until
February 2006. The Medicines Company has a significant marketed product with two other products in late stage clinical development. From 1986 to 1996 Dr. Villiger held various positions in product development at Roche in both New Zealand and
Switzerland, including International Project Director from 1991 to 1995 and Head of Global Project Management from 1995 to 1996. As Head of Global Project Management, he oversaw the development of Roches pharmaceutical portfolio, with programs
in Switzerland, the UK, U.S. and Japan. Dr. Villiger holds has a Ph.D. in psychopharmacology from the University of Otago.

There are
no family relationships between any of our executive officers or directors.

Composition of the Board of Directors

We regard Messrs. Kiefel, McComas, Farrell, Villiger and Hanley as independent non-executive directors for purposes of applicable Australian law, as
described by the Pharmaxis Corporate Governance Framework, and in accordance with the Principles of Good Corporate Governance and Best Practice Recommendations issued by the Australian Securities Exchange.

We do not regard Dr. Robertson as an independent director under applicable Australian law as he is a Pharmaxis executive officer.

Scientific Advisory Board

The members of the
Pharmaxis Scientific Advisory Board play an important role advising us in their areas of expertise.

Sandra Anderson, B.Sc., Ph.D.,
D.Sc., FANZSRS,is an expert in the diagnosis and treatment of asthma. She is a world authority in the measurement, management and mechanisms of exercise-induced asthma, and has developed a variety of tests for identifying asthma, including
Aridol. A prolific author and the recipient of numerous awards for her work, Dr. Anderson is Principal Hospital Scientist in the Department of Respiratory Medicine of the Royal Prince Alfred Hospital, Sydney. She is a Vice President of Asthma
NSW and Co-Chairman of their Research Advisory Committee. Dr. Anderson has served on various international taskforces and committees and is currently part of an independent panel of the International Olympic Committee Medical Commission. She is
actively engaged



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in our development, participating in technical presentations to various opinion leaders and regulatory authorities around the world. Dr. Anderson holds
a Bachelor of Science in Physiology from the University of Sydney and a Ph.D. in Medicine from the University of London.

Norbert
Berend, M.B., B.S., M.D., FRACP,is Director of the Woolcock Institute of Medical Research at Royal Prince Alfred Hospital, Sydney and is internationally recognized for his work in chronic obstructive pulmonary disease. Dr. Berend is active
in national and international peer groups, is a member of the COPD Guidelines Working Party, and serves on the Respiratory Clinical Expert Reference Committee of the NSW Department of Health. In addition, he is a Senior Investigator for the
Cooperative Research Centre, or CRC, for Asthma and a Director of the CRC for Chronic Inflammatory Diseases and is the author of more than 95 publications on airways disease, emphysema and infection in COPD. Dr. Berend was a principal
investigator at one site participating in the Aridol trial as well as serving on trial related safety committees.

Malcolm Fisher, A.O.,
M.B., Ch.B., M.D.,is renowned for his work in critical care medicine, having received numerous awards and being named an officer in the Order of Australia. Based in Sydney, Dr. Fisher is a Staff Specialist in the Intensive Care Unit of
Royal North Shore Hospital, and Area Director of Intensive Care and Clinical Professor in Intensive Care Medicine in the Departments of Medicine and Anaesthesia at the University of Sydney. He is a past President of the World Federation of Intensive
and Critical Care Medicine Societies, and its Australasian chapter, ANZICS. He is the author of two books and more than 130 scientific articles.

Richard J.I. Morgan, C.Biol., MIBiol., DRCPath, has more than 25 years experience in pharmaceutical research and development, and has been involved in the development of a large number of successful, marketed pharmaceutical
products. He has held senior management positions within preclinical safety (a vital precursor to human clinical trials), including Head of Toxicology at the pharmaceutical company Wellcome and International Head of Toxicology and Preclinical
Outsourcing for GlaxoWellcome (later GlaxoSmithKline). He has been responsible for evaluating the preclinical safety of more than 100 new chemical entities, ranging from anti-infectives and anti-parasitics to cancer compounds and vaccines. He
currently advises U.K. and Australian companies on toxicology and preclinical discovery and development. Mr. Morgan consults to Pharmaxis on the preclinical safety aspects of developing products.



|B. | Compensation
|-- | ------------

Principles used to determine the
nature and amount of remuneration.As a company building an international pharmaceutical business, we require a board of directors and executive team that have both the technical capability and relevant experience to execute our business plan.
We consider options to purchase ordinary shares a key tool in attracting the required talented individuals to our board of directors and executive team while staying within the fiscal constraints of a growing company. Director and executive
compensation includes a mix of short and long-term components. Compensation of executive directors and other executives includes a meaningful proportion that varies with individual performance. Cash incentives and the vesting of options granted to
executives are subject to performance assessment by the Remuneration and Nomination Committee. Individual performance targets are set by reference to the components of our annual business plan for which the individual executive is responsible. Each
year the Remuneration and Nomination Committee evaluates the performance of the chief executive officer and reviews and approves recommendations by the chief executive officer in relation to the performance of other executive officers. Compensation
of executive directors and other executives are reviewed each year with changes typically taking effect on January 1 each year. As non-executive directors assess individual and company performance, their remuneration does not have a variable
performance related component.

Non-executive directors.Fees and payments to non-executive directors reflect the demands that are
made on, and the responsibilities of, the directors. Non-executive directors fees and payments are reviewed annually by the Remuneration and Nomination Committee of the Board.

There are two components to the fees of independent non-executive directors:



| |  |  | a base fee of A$110,000 for the chairman and $60,000 for other non-executive directors;
| | - |  | ---------------------------------------------------------------------------------------



| |  |  | an flat annual fee for non-executive directors serving on committees A$5,000 as a committee member and A$10,000 as a committee chair; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | independent non-executive directors are allowed to package their remuneration to include superannuation and as from the 2006 fiscal year, options in the company.
Options are granted under the Pharmaxis Ltd Employee Option Plan and vest in the year of grant. Options granted to directors upon joining the Board and options granted before fiscal 2006 vest over a period of approximately four years.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

BH Smith was a former non-executive director during the year and is a principal of a venture capital firms that manage
funds which are significant shareholders of us. BH Smith was paid a cash fee of $10,174 from July 1, 2006 until her retirement on October 26, 2006 and was not granted any options in us.

Non-executive directors fees (including statutory superannuation) are determined within an aggregate directors fee pool limit, which is
periodically recommended for approval by shareholders. The pool currently stands at a maximum of $600,000 in total. The amount paid to non-executive directors in 2007 was A$209,105. Subject to the requirements of Australian law, termination payments
apply only to executive directors, as discussed below.

Executive directors and executive officers.There are four components to executive director
and executive officer remuneration:



| |  |  | annual base salary paid in cash or packaged at the executives discretion within Australian fringe benefits tax guidelines as a total cost package;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | annual statutory superannuation fund contributions of 9% of the executives base salary;
| | - |  | ----------------------------------------------------------------------------------------



| |  |  | a variable incentive component payable annually dependent upon achievement of performance targets set and approved by the Remuneration and Nomination Committee; and
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | options to purchase ordinary shares under the Pharmaxis Employee Option Plan. Options typically vest over a four-year time frame. For options granted after
January 1, 2003, the number of an individual executive directors or officers options vesting is subject to achievement of the performance targets set and approved by the Remuneration and Nomination Committee. The Remuneration and
Nomination Committee may approve the vesting of all or only a portion of the relevant options. Founder options were granted in 2003 to the founding scientists, Dr. Cowden and Dr. Charlton. These options became fully vested at June 30,
2003. Sign-on options were granted to Mr. McGarvey in 2003, to Mr. Crapper and Mr. Phillips in 2004 and Dr. McDonald in 2005. Sign-on options fully vest on the first anniversary of the executive commencing employment with us.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Base pay for executive directors and executive officers is reviewed annually to ensure the executives pay is
competitive with the market. An executives pay is also reviewed on promotion. The employment contracts for each of the above-listed executive directors and executive officers, which are described below, can be terminated immediately by us for
serious misconduct, with one months prior notice if the employee becomes mentally or physically unfit to perform or carry out their employment, with two months prior notice if the executives position ceases to exist, and with three
months prior notice without cause. Subject to requirements of Australian law, no additional payments apply on termination.



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Executive Compensation

The following table presents all of the compensation awarded to, earned by or paid to each individual who served as a member of our board of directors or as an executive officer in fiscal 2007.

Summary Compensation Table



|                             |  |                              |         |                 |               |                             |        |                  |    |        |    |   |       |  |   |         |  |   |        
|---------------------------- |  | ---------------------------- | ------- | --------------- | ------------- | --------------------------- | ------ | ---------------- | -- | ------ | -- | - | ----- |  | - | ------- |  | - | -------
|                             |  | Primary                      |         | Super-annuation |               | LongServiceLeaveEntitlement |        | EquityOptions(1) |    | Total 
|Name                         |  | Cash salaryor DirectorsFees |         |                 | CashIncentive |                             |        |                  |   
|                             |  | A$                           |         |                 | A$            |                             | A$     |                  | A$ |        | A$ |   | A$   
|Directors                    |  |                              |         |                 |               |                             |        |                  |    |        |    |   |       |  |   |         |  |   |        
|Alan D. Robertson, Ph.D. (2) |  | $                            | 329,025 |                 |               | $                           | 93,500 |                  | $  | 29,612 |    | $ | 8,205 |  | $ | 197,505 |  | $ | 647,847
|Denis M. Hanley              |  |                              | 66,644  | *               |               |                             |       |                  |    | 5,998  |    |   |       |  |   | 52,668  |  |   | 125,310
|Brigitte H. Smith (3)        |  |                              | 10,174  | *               |               |                             |       |                  |    |       |    |   |      |  |   |        |  |   | 10,174 
|Charles P.H. Kiefel          |  |                              | 6,987   | *               |               |                             |       |                  |    | 29     |    |   |      |  |   |        |  |   | 71,478 
|Malcolm J. McComas           |  |                              | 42,985  | *               |               |                             |       |                  |    |       |    |   |      |  |   |        |  |   | 69,319 
|Peter C. Farrell, Ph.D.      |  |                              | 40,688  | *               |               |                             |       |                  |    |       |    |   |      |  |   |        |  |   | 330,362
|John Villiger, Ph.D. (4)     |  |                              |        |                 |               |                             |       |                  |    |       |    |   |      |  |   |        |  |   |       
|Executive Officers           |  |                              |         |                 |               |                             |        |                  |    |        |    |   |       |  |   |         |  |   |        
|Brett Charlton, Ph.D.        |  |                              | 251,525 |                 |               |                             | 40,000 |                  |    | 22,601 |    |   | 6,264 |  |   | 139,409 |  |   | 459,799
|John F. Crapper              |  |                              | 235,750 |                 |               |                             | 40,000 |                  |    | 21,218 |    |   | 4,554 |  |   | 132,770 |  |   | 434,292
|Ian A. McDonald              |  |                              | 184,756 |                 |               |                             | 20,000 |                  |    | 16,628 |    |   | 1,359 |  |   | 132,770 |  |   | 355,513
|David M. McGarvey            |  |                              | 261,375 |                 |               |                             | 40,000 |                  |    | 23,524 |    |   | 5,516 |  |   | 132,770 |  |   | 463,185
|Gary J. Phillips             |  |                              | 260,775 |                 |               |                             | 40,000 |                  |    | 23,470 |    |   | 4,413 |  |   | 132,770 |  |   | 461,428

---

|(1) | The fair value of options granted during the year were estimated on the date of each grant using the Black-Scholes option pricing model.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------



|(2) | Individual also serves as an executive officer.
|--- | -----------------------------------------------



|(3) | Ms Smith retired as a director in October 2006.
|--- | -----------------------------------------------



|(4) | Dr. Villiger was appointed as a director in November 2006.
|--- | ----------------------------------------------------------



|* | Directors fees.
|- | ----------------

Stock Option Grants in Fiscal 2007

Details of options to purchase our ordinary shares provided during the fiscal year ended June 30, 2007 as remuneration to each of
our directors and our executive officers are set out below. When exercisable, each option is convertible into one ordinary share of Pharmaxis. Options are issued at a zero purchase price. Vesting details are set out in the subsequent table.



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##### Table of Contents

|                             |  |                           |  |               |      |                |           
|---------------------------- |  | ------------------------- |  | ------------- | ---- | -------------- | ----------
|Name                         |  | Number of Options Granted |  | ExercisePrice |      | ExpirationDate
|                             |  |                           |  | A$            |      |               
|Directors                    |  |                           |  |               |      |                |           
|Alan D. Robertson, Ph.D. (1) |  | 150,000                   |  | $             | 1.92 |                | 08/14/2016
|Peter C. Farrell, Ph.D.      |  | 220,000                   |  |               | 1.92 |                | 08/14/2016
|Denis M. Hanley              |  | 40,000                    |  |               | 1.92 |                | 08/14/2016
|Charles P.H. Kiefel          |  | 48,957                    |  |               | 1.92 |                | 08/14/2016
|Malcolm. M. McComas          |  | 20,000                    |  |               | 1.92 |                | 08/14/2016
|                             |  |                           | 
|Name                         |  | Number of Options Granted |  | ExercisePrice |      | ExpirationDate
|                             |  |                           |  | A$            |      |               
|Executive Officers           |  |                           |  |               |      |                |           
|Brett Charlton, Ph.D.        |  | 105,000                   |  |               | 1.92 |                | 08/14/2016
|John F. Crapper              |  | 100,000                   |  |               | 1.92 |                | 08/14/2016
|Ian A. McDonald, Ph.D.       |  | 100,000                   |  |               | 1.92 |                | 08/14/2016
|David M. McGarvey            |  | 100,000                   |  |               | 1.92 |                | 08/14/2016
|Gary J. Phillips             |  | 100,000                   |  |               | 1.92 |                | 08/14/2016



|(1) | Individual also serves as an executive officer.
|--- | -----------------------------------------------

Stock Option Grants
since June 30, 2007

On August 9, 2007 the board of directors proposed to grant under the Pharmaxis Employee Option Plan
1,250,000 options to executive officers, 300,000 options to the executive director and 336,000 options to other employees. The options have an exercise price of $3.89 and expire 9 August 2017. The grant of options to directors requires
shareholder approval and the 2006 annual meeting approved the grant of up to 150,000 options to the executive director. The 2007 annual meeting approved of the grant of an additional 150,000 options bringing the total to 300,000t. The 1,250,000
executive officer options were granted together with the 336,000 options to other employees on August 10, 2007.

On November 15,
2006 the board of directors proposed a grant of 200,000 options under the Pharmaxis Employee Option Plan to Dr. John Villiger upon his appointment to the Board. The proposed grant of options has an exercise price of $3.2258 and expire on
14 November 2016. The 2007 annual meeting approved this grant of options to Dr Villiger.

Details of grants to executive officers and
directors are presented below. When exercisable, each option is convertible into one ordinary share of Pharmaxis. Options are issued at a zero purchase price. Vesting details for granted options are presented in the subsequent table.



|                             |  |                           |  |               |       |                |           
|---------------------------- |  | ------------------------- |  | ------------- | ----- | -------------- | ----------
|Name                         |  | Number of Options Granted |  | ExercisePrice |       | ExpirationDate
|                             |  |                           |  | A$            |       |               
|Directors                    |  |                           |  |               |       |                |           
|Alan D. Robertson, Ph.D. (1) |  | 300,000                   |  | $             | 3.389 |                | 08/09/2017
|John Villiger, Ph.D.         |  | 200,000                   |  | $             | 3.226 |                | 11/14/2016
|                             |  |                           | 
|Name                         |  | Number of Options Granted |  | ExercisePrice |       | ExpirationDate
|                             |  |                           |  | A$            |       |               
|Executive Officers           |  |                           |  |               |       |                |           
|Brett Charlton, Ph.D.        |  | 250,000                   |  |               | 3.389 |                | 08/09/2017
|John F. Crapper              |  | 250,000                   |  |               | 3.389 |                | 08/09/2017
|Ian A. McDonald, Ph.D.       |  | 250,000                   |  |               | 3.389 |                | 08/09/2017
|David M. McGarvey            |  | 250,000                   |  |               | 3.389 |                | 08/09/2017
|Gary J. Phillips             |  | 250,000                   |  |               | 3.389 |                | 08/09/2017

---

|(1) | Individual also serves as an executive officer.
|--- | -----------------------------------------------



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##### Table of Contents

Stock Option Values

Option holdings

The numbers of options to purchase our ordinary shares held at November 6, 2007 by each
director of Pharmaxis and each of the executive officers are listed below. When exercisable, each option is convertible into one ordinary share of Pharmaxis. Options are issued at a zero purchase price.



|                            |  |                     |  |               |        |                |            |         |                                                       
|--------------------------- |  | ------------------- |  | ------------- | ------ | -------------- | ---------- | ------- | ------------------------------------------------------
|Name                        |  | Number ofSecurities |  | ExercisePrice |        | ExpirationDate |            | Vesting
|                            |  |                     |  | A$            |        |                |            |        
|Directors                   |  |                     |  |               |        |                |            |         |                                                       
|Alan D. Robertson, Ph.D.(1) |  | 1,120,000           |  | $             | 0.1250 |                | 11/30/2009 |         | 280,000 at each of June 30, 2000, 2001,2002 and 2003  
|                            |  | 960,000             |  |               | 0.3125 |                | 06/30/2012 |         | 240,000 at each of June 30, 2003, 2004,2005 and
2006  
|                            |  | 150,000             |  |               | 1.790  |                | 08/04/2015 |         | 37,500 at each of June 30, 2006, 2007,2008 and
2009(2)
|                            |  | 150,000             |  |               | 1.917  |                | 08/14/2016 |         | 37,500 at each of June 30, 2007, 2008,2009 and
2010(2)
|                            |  | 300,000             |  |               | 3.389  |                | 08/09/2017 |         | 75,000 at each of June 30, 2008, 2009,2010 and
2011(2)
|Denis M. Hanley             |  | 640,000             |  |               | 0.3125 |                | 08/30/2011 |         | 640,000 at August 30, 2002                            
|                            |  | 400,000             |  |               | 0.3125 |                | 06/30/2012 |         | 100,000 at each of June 30, 2003, 2004,2005 and
2006  
|                            |  | 40,000              |  |               | 1.790  |                | 08/04/2015 |         | 10,000 at each of June 30, 2006, 2007,2008 and
2009   
|                            |  | 40,000              |  |               | 1.917  |                | 08/14/2016 |         | 40,000 at each October 26, 2006                       



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##### Table of Contents

|                        |  |                     |  |               |  |                 |  |                                                        
|----------------------- |  | ------------------- |  | ------------- |  | --------------- |  | -------------------------------------------------------
|Name                    |  | Number ofSecurities |  | ExercisePrice |  | Expiration Date |  | Vesting                                                
|                        |  |                     |  | A$            |  |                 |  |                                                        
|Peter C. Farrell, Ph.D. |  | 200,000             |  | 2.068         |  | 04/30/2013      |  | 50,000 at each of June 30, 2007, 2008,2009 and 2010    
|                        |  | 20,000              |  | 1.917         |  | 08/14/2016      |  | 20,000 ay October 26, 2006                             
|Charles P.H. Kiefel     |  | 200,000             |  | 0.3125        |  | 04/30/2013      |  | 50,000 at each of June 30, 2004, 2005,2006 and 2007    
|                        |  | 20,000              |  | 1.790         |  | 08/04/2015      |  | 5,000 at each of June 30, 2006, 2007,2008 and
2009     
|                        |  | 48,957              |  | 1.917         |  | 08/14/2016      |  | 48,957 at October 26, 2006                             
|John Villiger, PhD      |  | 200,000             |  | 3.226         |  | 11/14/2016      |  | 50,000 at each of June 30, 2007, 2008,2009 and 2010    
|Malcolm. M. McComas     |  | 200,000             |  | 0.3125        |  | 07/03/2013      |  | 50,000 at each of June 30, 2004, 2005,2006 and 2007    
|                        |  | 20,000              |  | 1.790         |  | 08/04/2015      |  | 5,000 at each of June 30, 2006, 2007,2008 and
2009     
|                        |  | 20,000              |  | 1.917         |  | 08/14/2016      |  | 20,000 at October 26, 2006                             
|Executive Officers      |  |                     |  |               |  |                 |  |                                                        
|Brett Charlton, Ph.D.   |  | 480,000             |  | 0.3125        |  | 06/30/2012      |  | 480,000 at June 30, 2003                               
|                        |  | 370,000             |  | 0.3125        |  | 06/30/2012      |  | 120,000 at each of June 30, 2003, 2004,2005 and 2006   
|                        |  | 105,000             |  | 1.790         |  | 08/04/2015      |  | 26,250 at each of June 30, 2006, 2007,2008 and
2009(2) 
|                        |  | 105,000             |  | 1.917         |  | 08/14/2016      |  | 26,250 at each of June 30, 2007, 2008,2009 and
2010(2) 
|                        |  | 250,000             |  | 3.389         |  | 08/09/2017      |  | 62,500 at each of June 30, 2008, 2009,2010 and
2011(2) 
|John F. Crapper         |  | 180,000             |  | 0.3125        |  | 06/30/2013      |  | 480,000 at July 1, 2004                                
|                        |  | 180,000             |  | 0.3125        |  | 06/30/2013      |  | 120,000 at each of June 30, 2004, 2005,2006 and 2007(2)
|                        |  | 100,000             |  | 1.7900        |  | 08/04/2015      |  | 25,000 at each of June 30, 2006, 2007,2008 and 2009(2) 
|                        |  | 100,000             |  | 1.917         |  | 08/14/2016      |  | 25,000 at each of June 30, 2007, 2008,2009 and 2010(2) 
|                        |  | 250,000             |  | 3.389         |  | 08/09/2017      |  | 62,500 at each of June 30, 2008, 2009,2010 and
2011(2) 
|Ian A. McDonald, Ph.D.  |  | 50,000              |  | 1.1470        |  | 05/11/2015      |  | April 3, 2006                                          
|                        |  | 150,000             |  | 1.1470        |  | 05/11/2015      |  | 37,500 at each of June 30, 2006, 2007,2008 and 2009(2) 
|                        |  | 20,000              |  | 1.7900        |  | 08/04/2015      |  | 5,000 at each of June 30, 2006, 2007,2008 and 2009(2)  
|                        |  | 100,000             |  | 1.917         |  | 08/14/2016      |  | 25,000 at each of June 30, 2007, 2008,2009 and 2010(2) 
|                        |  | 250,000             |  | 3.389         |  | 08/09/2017      |  | 62,500 at each of June 30, 2008, 2009,2010 and
2011(2) 
|David M. McGarvey       |  | 480,000             |  | 0.3125        |  | 06/30/2012      |  | 120,000 at each of June 30, 2003, 2004,2005 and 2006(2)
|                        |  | 480,000             |  | 0.3125        |  | 11/30/2012      |  | 480,000 at December 1, 2003                            
|                        |  | 100,000             |  | 1.7900        |  | 08/04/2015      |  | 25,000 at each of June 30, 2006, 2007,                 



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##### Table of Contents

|                 |  |         |  |        |  |            |  |                                                       
|---------------- |  | ------- |  | ------ |  | ---------- |  | ------------------------------------------------------
|                 |  |         |  |        |  |            |  | 2008 and 2009(2)                                      
|                 |  | 100,000 |  | 1.917  |  | 08/14/2016 |  | 25,000 at each of June 30, 2007, 2008,2009 and 2010(2)
|                 |  | 250,000 |  | 3.389  |  | 08/09/2017 |  | 62,500 at each of June 30, 2008, 2009,2010 and
2011(2)
|Gary J. Phillips |  | 250,000 |  | 0.3760 |  | 11/30/2013 |  | 62,500 at each of June 30, 2004, 2005,2006 and 2007(2)
|                 |  | 250,000 |  | 0.3760 |  | 11/30/2013 |  | 250,000 at December 1, 2004                           
|                 |  | 105,000 |  | 1.7900 |  | 08/04/2015 |  | 26,250 at each of June 30, 2006, 2007,2008 and 2009(2)
|                 |  | 100,000 |  | 1.917  |  | 08/14/2016 |  | 25,000 at each of June 30, 2007, 2008,2009 and 2010(2)
|                 |  | 250,000 |  | 3.389  |  | 08/09/2017 |  | 62,500 at each of June 30, 2008, 2009,2010 and
2011(2)



|(1) | Individual also serves as an executive officer.
|--- | -----------------------------------------------



|(2) | Vesting is subject to approval of the Remuneration and Nomination Committee.
|--- | ----------------------------------------------------------------------------

Employment Agreements

The following executive directors and executive officers have employment agreements with Pharmaxis.
Each of these agreements provides for the provision of performance-related cash incentives and participation, when eligible, in the Pharmaxis Employee Option Plan. These agreements also contain certain confidentiality, intellectual property and non
competition provisions that serve to protect our intellectual property rights and other proprietary information.

The employment agreements
can only be terminated by us without notice if for cause. Should an employee become mentally or physically unfit to fulfill his duties, we may terminate his employment upon one months advance notice. If termination is due to the elimination of
such employees position, then two months advance notice is required prior to any termination. For any other termination without cause, we are required to provide the employee three months advance notice. During the above noted notice periods,
the employee is entitled to his base salary and other benefits. Upon termination, the employee is also entitled to payment of any accrued annual leave benefits.

In addition to their respective base salaries, each of the following executive officers may be awarded an annual performance bonus upon satisfaction of certain milestones upon the sole discretion of our Remuneration
and Nomination Committee and as approved by the board of directors.

Other material terms of each of these agreements are identified below.

Alan D. Robertson, Ph.D., Chief Executive Officer and Managing Director



| |  |  | Subject to earlier termination by us, the term of Dr. Robertsons employment will last until June 30, 2008, unless the term of the employment
agreement is either extended or Dr. Robertson enters into a new employment agreement with us;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The employment agreement provides for an annual base salary of A$321,000, which may be subject to increase upon review annually by our Remuneration and Nomination
Committee and as approved by the board of directors; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | We also make superannuation fund contributions equal to 9% of the annual base salary, or A$28,890, per year for the benefit of Dr. Robertson.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------

Brett Charlton, Ph.D., Medical Director



| |  |  | Subject to earlier termination by us, the term of Dr. Charltons employment will last until June 30, 2008, unless the term of the employment
agreement is either extended or Dr. Charlton enters into a new employment agreement with us;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

| |  |  | The employment agreement provides for an annual base salary of A$245,000, which may be subject to increase upon review annually by our Remuneration and Nomination
Committee and as approved by the board of directors; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | We also make superannuation contributions equal to 9% of the annual base salary, or A$22,050, per year for the benefit of Dr. Charlton.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------

John F. Crapper, Chief Operations Officer



| |  |  | Subject to earlier termination by us, the term of Mr. Crappers employment will last until June 30, 2008, unless the term of the employment agreement
is either extended or Mr. Crapper enters into a new employment agreement with us;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The employment agreement provides for an annual base salary of A$230,000, which may be subject to increase upon review annually by our Remuneration and Nomination
Committee and as approved by the board of directors; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | We also make superannuation contributions equal to 9% of the annual base salary, or A$20,700, per year for the benefit of Mr. Crapper.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------

Ian A, McDonald, Ph.D., Chief Scientific Officer



| |  |  | Subject to earlier termination by us, the term of Dr. McDonalds employment will last until June 30, 2010, unless the term of the employment
agreement is either extended or Dr. McDonald enters into a new employment agreement with us;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The employment agreement provides for an annual base salary of A$200,000, which may be subject to increase upon review annually by our Remuneration and Nomination
Committee and as approved by the board of directors; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | We also make superannuation contributions equal to 9% of the annual base salary, or A$18,000, per year for the benefit of Dr. McDonald.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------

David M. McGarvey, C.A., C.P.A., Chief Financial Officer and Secretary



| |  |  | Subject to earlier termination by us, the term of Mr. McGarveys employment will last until June 30, 2008, unless the term of the employment
agreement is either extended or Mr. McGarvey enters into a new employment agreement with us;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The employment agreement provides for an annual base salary of A$255,000, which may be subject to increase upon review annually by our Remuneration and Nomination
Committee and as approved by the board of directors; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | We also make superannuation contributions equal to 9% of the annual base salary, or A$22,950, per year for the benefit of Mr. McGarvey.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------

Gary J. Phillips, Head of Commercial Development



| |  |  | Subject to earlier termination by us, the term of Mr. Phillips employment will last until June 30, 2008, unless the term of the employment agreement
is either extended or Mr. Phillips enters into a new employment agreement with us;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The employment agreement provides for an annual base salary of A$250,000, which may be subject to increase upon review annually by our Remuneration and Nomination
Committee and as approved by the board of directors; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | We are also required to make superannuation contributions equal to 9% of the annual base salary, or A$22,500, per year for the benefit of Mr. Phillips.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

Limitation of Liability and Indemnification Matters

Our Constitution provides that, except to the extent prohibited by the Corporations Act 2001, each of our officers shall be indemnified out of our funds
against any liability incurred by such person in his or her capacity as an officer in defending any legal proceedings, whether civil or criminal, in which judgment is given in such persons favor or where such officer is acquitted in connection
with any application under the Corporations Act 2001 and relief is granted to such officer by a court.

We have entered into Deeds of
Access to Documents and Indemnity agreements to indemnify our directors and certain of our executive officers and to provide contractual indemnification in addition to the indemnification provided for in our Constitution. We believe that these
provisions and agreements are necessary to attract and retain qualified directors and executive officers. Our Constitution also permits us, to the extent permitted by law, to secure insurance on behalf of any officer for any liability arising out of
his or her actions.

At present, there is no pending litigation or proceeding involving any of our directors, officers, employees or agents
where indemnification by us will be required or permitted, and we are not aware of any threatened litigation or proceeding that may result in a claim for such indemnification.

We maintain directors and officers liability insurance providing for the indemnification of our directors and officers against certain
liabilities incurred as a director or officer, including costs and expenses associated in successfully defending legal proceedings. We intend to continue to maintain this insurance in the future.

Severance and Change of Control Agreements

Details
of the severance payments owed to directors upon termination are set out above. See Item 6 Directors, Senior Management and Employees.

Employee Option Plan

Any person considered to be an employee of Pharmaxis, or any subsidiary of Pharmaxis, by our board of
directors including executive directors and non-executive directors are eligible to participate in the Pharmaxis Employee Option Plan, but do so at the invitation of our board of directors. Under the Pharmaxis Employee Option Plan, the board of
directors may issue options to purchase our ordinary shares on such terms, including the issue price, the exercise price and the vesting conditions, as it determines. The maximum number of options available to be issued under the Pharmaxis Employee
Option Plan at any given time is 15% of our total issued shares and other securities convertible into shares at such time, or such number as is consistent with any Listing Rules or laws or regulations that apply to Pharmaxis.

Any vesting conditions determined by our board of directors must be satisfied before the employee options vest and become exercisable. Options are
generally granted for no consideration. Options granted to executives and employees vest in equal tranches over a four-year period. For options granted after January 1, 2003, the annual vesting is subject to approval by the Remuneration and
Nomination Committee of our board of directors. The Remuneration and Nomination Committee gives its approval for vesting based on the achievement of individual employees personal annual objectives. Independent non-executive directors are
granted options on joining the Board and from fiscal 2006, are allowed to package their remuneration to include options in the company. Options are granted under the Pharmaxis Ltd Employee Option Plan. Options granted to directors upon joining the
Board and options granted before fiscal 2006 vest over a period of approximately four years. Other options granted to non-executive directors vest in the year of grant. If a takeover offer is made for Pharmaxis, all options which have not yet
vested, vest.

When exercisable, each option issued under the Pharmaxis Employee Option Plan entitles the holder to subscribe for one fully
paid ordinary share. Each ordinary share issued on exercise of an option will rank equally with all other ordinary shares then issued.

The
exercise price of the employee options is set by our board of directors. Before we listed on the Australian Securities Exchange in November 2003, our board of directors set the exercise price based on its assessment of the market value of the
underlying shares at the time of grant. From listing on the Australian Securities Exchange, the exercise price is set by our board of directors as the average closing price of our ordinary



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##### Table of Contents

shares on the Australian Securities Exchange during the five business days prior to the grant of the options. From September 1, 2006 the exercise price
is set by our board of directors as the average of the volume weighted average price of Pharmaxis shares on the Australian Securities Exchange on the five business days prior to the grant of the options.

The employee options lapse on such date as determined by the board of directors at the time of grant. If an optionholder ceases to be regarded as an
employee by our board of directors, all of his or her options which have not yet vested lapse and all options which have already vested lapse, if not exercised, within 30 days of such determination. If an employee is terminated for cause, dishonesty
or fraud, his or her options lapse immediately on ceasing to be an employee. If an employee dies, all options which have not vested lapse and all options which have vested, lapse on the date 12 months after the death of the employee (to the extent
that they are not exercised by the estate of the former employee).

The employee options which have not been exercised do not confer a
right to notices of general meetings (except as may be required by law) or a right to attend, speak or vote at general meetings.

A holder
of employee options may only participate in new issues of securities with respect to options which have been exercised and ordinary shares issued prior to the record date.

In the event of a consolidation, subdivision or similar reconstruction of our issued share capital, the number of shares to which a holder of options is
entitled on exercise of an option will be adjusted in the same proportion as our issued share capital is consolidated, subdivided or reconstructed (as applicable) and an appropriate adjustment will be made to the exercise price with the effect that
the total amount payable on an exercise of all options by each holder will not change.

If any pro-rata offer is made by us to at least all
holders of shares, the exercise price of the relevant employee options will be reduced according to a formula set out in the Pharmaxis Employee Option Plan and consistent with the Listing Rules of the Australian Securities Exchange.

If we make a bonus issue of ordinary shares to our shareholders, the number of ordinary shares over which the employee options are exercisable may be
increased by the number of shares the relevant option holder would have received if the option had been exercised prior to the record date of the bonus issue.

If we make a return of capital to our shareholders generally, the exercise price of the employee options will be proportionately reduced by the amount of the return of capital.

Except by transmission on death or with the prior written consent of our board of directors, employee options may not be transferred, encumbered,
assigned or otherwise disposed of by the relevant employee. Shares issued upon exercise of options are freely transferable and we seek quotation of any such shares on the Australian Securities Exchange.

The Pharmaxis Employee Option Plan may be amended with any necessary approvals under the Corporations Act 2001 and the Listing Rules of the Australian
Securities Exchange. The Corporations Act 2001 and the Listing Rules of the Australian Securities Exchange prevail over the Pharmaxis Employee Option Plan to the extent of any inconsistency. The Pharmaxis Employee Option Plan is administered by the
board of directors and the Remuneration and Nomination Committee.

Presented below are summaries of options granted under the Pharmaxis
Employee Option Plan during fiscal 2006 and fiscal 2007. During the period between July 1, 2007 and November 9, 2007 options to purchase 2,613,000 ordinary shares were granted, options to purchase 655,750 ordinary shares were exercised,
and options to purchase 143,000 ordinary shares lapsed. As of November 9, 2007, options to purchase 11,649,457 ordinary shares were outstanding.



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##### Table of Contents

Year ended June 30, 2007



|                         |  |                 |  |               |        |                              |            |                        |           |                           |           |                         |         |                              |          
|------------------------ |  | --------------- |  | ------------- | ------ | ---------------------------- | ---------- | ---------------------- | --------- | ------------------------- | --------- | ----------------------- | ------- | ---------------------------- | ---------
|Grant date               |  | Expiration Date |  | ExercisePrice |        | Balance atStart of thePeriod |            | IssuedDuring thePeriod |           | ExercisedDuring thePeriod |           | LapsedDuring the Period |         | Balance at End of the Period
|                         |  |                 |  | A$            |        |                              |            |                        |           |                           |           |                         |         |                             
|12/01/1999               |  | 11/30/2009      |  | $             | 0.1250 |                              | 1,120,000  |                        |          |                           |          |                         |        |                              | 1,120,000
|07/01/2000               |  | 06/30/2010      |  |               | 0.1250 |                              | 60,000     |                        |          |                           | 60,000    |                         |        |                              |         
|09/01/2001               |  | 08/30/2011      |  |               | 0.3125 |                              | 640,000    |                        |          |                           |          |                         |        |                              | 640,000  
|12/02/2001               |  | 11/30/2011      |  |               | 0.1250 |                              | 160,000    |                        |          |                           | 60,000    |                         |        |                              | 100,000  
|05/12/2003               |  | 06/30/2012      |  |               | 0.3125 |                              | 3,502,000  |                        |          |                           | 380,000   |                         |        |                              | 3,122,000
|05/12/2003               |  | 11/30/2012      |  |               | 0.3125 |                              | 480,000    |                        |          |                           |          |                         |        |                              | 480,000  
|05/12/2003               |  | 04/30/2013      |  |               | 0.3125 |                              | 216,000    |                        |          |                           | 200,000   |                         |        |                              | 16,000   
|07/01/2003               |  | 06/30/2013      |  |               | 0.3125 |                              | 660,000    |                        |          |                           | 300,000   |                         |        |                              | 360,000  
|07/04/2003               |  | 07/03/2013      |  |               | 0.3125 |                              | 200,000    |                        |          |                           |          |                         |        |                              | 200,000  
|12/09/2003               |  | 11/30/2013      |  |               | 0.3760 |                              | 500,000    |                        |          |                           |          |                         |        |                              | 500,000  
|04/25/2004               |  | 04/24/2014      |  |               | 0.5080 |                              | 22,500     |                        |          |                           |          |                         |        |                              | 22,500   
|06/04/2004               |  | 06/03/2014      |  |               | 0.4260 |                              | 15,000     |                        |          |                           |          |                         |        |                              | 15,000   
|02/02/2005               |  | 02/01/2015      |  |               | 0.8340 |                              | 255,000    |                        |          |                           | 7,500     |                         | 7,500   |                              | 240,000  
|05/12/2005               |  | 05/11/2015      |  |               | 1.1470 |                              | 330,000    |                        |          |                           | 2,500     |                         | 7,500   |                              | 320,000  
|08/05/2005               |  | 08/04/2015      |  |               | 1.7900 |                              | 954,500    |                        |          |                           | 35,625    |                         | 118,875 |                              | 800,000  
|10/17/2005               |  | 10/16/2015      |  |               | 2.7720 |                              | 155,000    |                        |          |                           |          |                         | 85,000  |                              | 70,000   
|02/13/2006               |  | 02/12/2016      |  |               | 2.1940 |                              | 310,000    |                        |          |                           |          |                         | 40,000  |                              | 270,000  
|06/01/2006               |  | 05/31/2016      |  |               | 2.0340 |                              | 111,500    |                        |          |                           |          |                         | 15,000  |                              | 96,500   
|08/15/2006               |  | 08/14/2016      |  |               | 1.9170 |                              |           |                        | 649,500   |                           |          |                         | 22,250  |                              | 627,250  
|10/26/2006               |  | 08/14/2016      |  |               | 1.9170 |                              |           |                        | 278,957   |                           |          |                         |        |                              | 278,957  
|09/20/2006               |  | 09/19/2016      |  |               | 1.8918 |                              |           |                        | 72,500    |                           |          |                         | 25,000  |                              | 47,500   
|10/26/2006               |  | 03/15/2016      |  |               | 2.0680 |                              |           |                        | 200,000   |                           |          |                         |        |                              | 200,000  
|12/14/2006               |  | 12/13/2016      |  |               | 3.0710 |                              |           |                        | 80,000    |                           |          |                         | 7,500   |                              | 72,500   
|06/18/2007               |  | 06/17/2016      |  |               | 3.3155 |                              |           |                        | 237,500   |                           |          |                         |        |                              | 237,500  
|                         |  |                 |  |               |        |                              |            |                        |           |                           |           |                         |         |                              |          
|                         |  |                 |  |               |        |                              | 9,691,500  |                        | 1,518,457 |                           | 1,045,625 |                         | 328,625 |                              | 9,835,707
|                        
|Year ended June 30, 2006
|                         |  |                 |  |               |        |                              |           
|Grant date               |  | Expiration Date |  | ExercisePrice |        | Balance atStart of thePeriod |            | IssuedDuring thePeriod |           | ExercisedDuring thePeriod |           | LapsedDuring the Period |         | Balance at End of the Period
|                         |  |                 |  | A$            |        |                              |            |                        |           |                           |           |                         |         |                             
|12/01/1999               |  | 11/30/2009      |  | $             | 0.1250 |                              | 2,400,000  |                        |          |                           | 1,280,000 |                         |        |                              | 1,120,000
|07/01/2000               |  | 06/30/2010      |  |               | 0.1250 |                              | 160,000    |                        |          |                           | 100,000   |                         |        |                              | 60,000   
|09/01/2001               |  | 08/30/2011      |  |               | 0.3125 |                              | 640,000    |                        |          |                           |          |                         |        |                              | 640,000  
|12/02/2001               |  | 11/30/2011      |  |               | 0.1250 |                              | 160,000    |                        |          |                           |          |                         |        |                              | 160,000  
|05/12/2003               |  | 06/30/2012      |  |               | 0.3125 |                              | 4,548,000  |                        |          |                           | 1,046,000 |                         |        |                              | 3,502,000
|05/12/2003               |  | 11/30/2012      |  |               | 0.3125 |                              | 480,000    |                        |          |                           |          |                         |        |                              | 480,000  
|05/12/2003               |  | 04/30/2013      |  |               | 0.3125 |                              | 216,000    |                        |          |                           |          |                         |        |                              | 216,000  
|07/01/2003               |  | 06/30/2013      |  |               | 0.3125 |                              | 960,000    |                        |          |                           | 300,000   |                         |        |                              | 660,000  
|07/04/2003               |  | 07/03/2013      |  |               | 0.3125 |                              | 200,000    |                        |          |                           |          |                         |        |                              | 200,000  
|12/09/2003               |  | 11/30/2013      |  |               | 0.3760 |                              | 500,000    |                        |          |                           |          |                         |        |                              | 500,000  
|04/25/2004               |  | 04/24/2014      |  |               | 0.5080 |                              | 30,000     |                        |          |                           | 7,500     |                         |        |                              | 22,500   
|06/04/2004               |  | 06/03/2014      |  |               | 0.4260 |                              | 15,000     |                        |          |                           |          |                         |        |                              | 15,000   
|02/02/2005               |  | 02/01/2015      |  |               | 0.8340 |                              | 275,000    |                        |          |                           |          |                         | 20,000  |                              | 255,000  
|05/12/2005               |  | 05/11/2015      |  |               | 1.1470 |                              | 330,000    |                        |          |                           |          |                         |        |                              | 330,000  
|08/05/2005               |  | 08/04/2015      |  |               | 1.7900 |                              |            |                        | 954,500   |                           |           |                         |         |                              | 954,500  
|10/17/2005               |  | 10/16/2015      |  |               | 2.7720 |                              |            |                        | 155,000   |                           |           |                         |         |                              | 155,000  
|02/13/2006               |  | 02/12/2016      |  |               | 2.1940 |                              |            |                        | 320,000   |                           |          |                         | 10,000  |                              | 310,000  
|06/01/2006               |  | 05/31/2016      |  |               | 2.0340 |                              |            |                        | 111,500   |                           |           |                         |         |                              | 111,500  
|                         |  |                 |  |               |        |                              |            |                        |           |                           |           |                         |         |                              |          
|                         |  |                 |  |               |        |                              | 10,914,000 |                        | 1,541,000 |                           | 2,733,500 |                         | 30,000  |                              | 9,691,500



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Retirement Benefits

We contribute to standard defined contribution superannuation funds on behalf of all employees at an amount of 9% of the employees salary. We permit employees to choose the superannuation fund into which the
contributions are paid, provided the fund is appropriately registered.

We contributed A$196,000 and A$337,000, A$454,000 and A$1,181,000
for the fiscal years ended June 30, 2005, 2006 and 2007, and the period from inception (May 29, 1998) to June 30, 2007.



|C. | Board Practices
|-- | ---------------

For the date of expiration of the
current term of office of our directors and senior management and the period during which the person has served in that office, see Item 6. Directors, Senior Management and Employees  A. Directors and Senior
Management.

For details of directors service contracts with the Company providing for benefits upon termination of employment,
see Item 6. Directors, Senior Management and Employees  B. Compensation  Employment Agreements.

Board of
Directors

Our board of directors currently consists of six directors, including five non-executive directors, of which one is
non-executive chairman. Under our Constitution, the number of directors will not, unless otherwise determined by an ordinary resolution of Pharmaxis, be less than three nor more than nine. A director need not be a shareholder of Pharmaxis. Only a
person over the age of 18 may be appointed as a director.

Our directors are subject to periodic retirement and re-election by shareholders
in accordance with our Constitution and the Listing Rules of the Australian Securities Exchange. At each annual general meeting, one-third of our directors who are subject to retirement by rotation or, if their number is not a multiple of three, the
nearest to one-third but not exceeding one-third, retire from office. Any director appointed by the directors since the last annual general meeting or for whom it would be their third annual general meeting must also retire from office. Any retiring
director is eligible for reappointment. Generally, the effect of the retirement by rotation provisions is that the directors retire and are subject to re-election at staggered intervals. Mr. McComas and Dr. Villiger will stand for
re-election as directors at our next annual general meeting to be held on November 5, 2007.

The directors may appoint one of
themselves as a managing director, for any period and on any terms as the directors decide. The retirement by rotation provisions do not apply to the managing director. A person ceases to be a director if the Corporations Act 2001 so provides, if
the director resigns by notice to Pharmaxis, if the shareholders in a general meeting remove the director, if the director is absent without the consent of the board of directors from all directors meetings during any six-month period, if the
director becomes mentally incapable and the directors estate or property has had a personal representative or trustee appointed to administer it, or if the director is an executive and he or she ceases to be an executive of Pharmaxis.

A director may appoint an alternate for a specified period with the consent of the directors. If the appointor of the alternate is not
present, the alternate may attend the directors meeting, count in the quorum, speak, and vote



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in the place of the appointor and exercise any other powers (except the power to appoint an alternate) that the appointor may exercise. We may pay an
alternate any remuneration the directors decide, in reduction of the appointors remuneration. We do not currently have any alternate directors.

The directors may meet, adjourn and otherwise regulate their meetings as they decide. Any director may call a directors meeting. The quorum for a directors meeting is two directors, unless the board of
directors decides otherwise. If a person appointed as an alternate director is already a director, he or she must be counted as a director and separately as an alternate for quorum purposes. If a person is an alternate for more than one director, he
or she must be counted separately for each appointment for quorum purposes. If there are not enough directors in office to form a quorum, the remaining directors may only act to increase the number of directors, to call a general meeting of
shareholders or in an emergency.

Subject to the Corporations Act 2001, each director has one vote. If a director is also an alternate, the
director has one vote as a director and one vote as an alternate. If a person is an alternate for more than one director, the person has one vote for each appointment. A resolution of the directors is passed by a majority of votes cast. Subject to
the Listing Rules of the Australian Securities Exchange, the chairman has a deciding vote.

Our board of directors are given all our powers
to manage our business except for any powers that the Corporations Act 2001, the Listing Rules of Australian Securities Exchange or our Constitution require Pharmaxis to exercise in a general meeting. The directors may execute documents on behalf of
Pharmaxis, execute negotiable instruments, delegate any of their powers to a committee of directors or to one director and may appoint any person to be our attorney and agent.

Subject to the Listing Rules of Australian Securities Exchange and the Corporations Act 2001, our directors are not prohibited from entering into
proposals, arrangements and contracts in which they are interested. A director must declare to Pharmaxis the nature of their material personal interest. This notification may be a standing notification. A director is not required to give notice of
an interest if the interest:



| |  |  | arises because the director hold shares in Pharmaxis in common with other shareholders;
| | - |  | ---------------------------------------------------------------------------------------



| |  |  | arises in relation to the directors remuneration as a director of Pharmaxis;
| | - |  | -----------------------------------------------------------------------------



| |  |  | relates to a contract we are proposing to enter into that is subject to approval by our shareholders and will not impose any obligation on Pharmaxis if it is not
approved by shareholders;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | arises merely because the director is a guarantor or has given an indemnity or security for all or part of a loan (or proposed loan) to Pharmaxis or arises merely
because the director has a right of subrogation in relation to a guarantee or indemnity;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | relates to a contract that insures, or would insure, the directors against liabilities the director incurs as an officer of a company (but only if the contract does
not make the company or related corporate entity the insurer);
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | relates to any payment by Pharmaxis or a related corporate entity in respect of an indemnity permitted under the Corporations Act 2001 or a contract relating to
such indemnity;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | is in a contract, or proposed contract, with, or for the benefit of, or on behalf of, a related corporate entity of Pharmaxis and arises merely because the director
is a director of the related corporate entity; or
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the director has already given a standing notice of the nature and extent of the interest and the materiality of the interest has not increased above that disclosed
in the notice.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

A director who has a material personal interest in a proposal, arrangement or contract that is being
considered at a directors meeting must not be present while the matter is being considered at the meeting or vote on the matter and may not be counted in a quorum unless the Corporations Act 2001 provides otherwise. The director may be present
and vote at such a directors meeting if the directors who do not have a material personal interest in the matter have passed a resolution that identifies the director, the nature and extent of the directors interest in the matter and its
relation to our affairs and states that those directors are satisfied that the interest should not disqualify the director from being present or voting.



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At a shareholders meeting, we will disregard any votes cast by a director or any associate of a director
who is voting in his or her capacity as a shareholder on a resolution relating to a proposal, arrangement or contract in which the director has a material personal interest if required to do so by the Listing Rules of the Australian Securities
Exchange. The Listing Rules of the Australian Securities Exchange provide that the votes of certain shareholders must be disregarded in a number of circumstances. Generally, a shareholders vote must be disregarded if the person may benefit
from the transaction that is the subject of the resolution (unless that benefit is received in their capacity as a shareholder in common with other shareholders). For example, a directors vote in his or her capacity as a shareholder may be
disregarded in respect of:



| |  |  | issues of shares or options requiring the approval of shareholders, if the director is entitled to acquire securities under the issue or has acquired securities
under the issue (subject to a range of exceptions including in respect of a pro-rata offer made to all shareholders);
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the issue of options to the director;
| | - |  | -------------------------------------



| |  |  | an increase in the remuneration payable to the directors;
| | - |  | ---------------------------------------------------------



| |  |  | termination benefits payable to directors;
| | - |  | ------------------------------------------



| |  |  | related party transactions, if the director or his or her associates may receive a benefit under a related party transaction; or
| | - |  | --------------------------------------------------------------------------------------------------------------------------------



| |  |  | any transaction if, in the view of the Australian Securities Exchange, the directors vote should be disregarded.
| | - |  | -----------------------------------------------------------------------------------------------------------------

We may not be required to disregard the vote of the director if the director is voting as a proxy for a person who is entitled to vote.

We may remunerate each director as the board of directors decides, but the total amount of the remuneration of non-executive directors may not exceed the
amount fixed by the shareholders in a general meeting. Other amounts may be payable by Pharmaxis to directors under our Constitution, including the payment of reasonable costs and expenses incurred in the performance of their duties or amounts paid
in respect of indemnity obligations. In addition, shareholder approval may also be required in relation to the remuneration of executive directors unless the remuneration would be reasonable given our circumstances and the role of the director. Our
Remuneration and Nomination Committee is responsible for recommending to the board of directors the remuneration to be paid to both non-executive directors and executive directors.

In order to loan money or give similar financial benefits to a director, we must either obtain the approval of shareholders or the financial benefit must
fall under an approved exception under the Corporations Act 2001. In the case of a loan, shareholder approval may not be required if the terms of the loan are reasonable in the circumstances (as though the parties were dealing on arms length terms)
or the terms are less favorable to the director than reasonable notional arms length terms or if the financial benefit is an amount which does not exceed A$2,000. Our policies, however, ban loans to directors and executive officers.

Committees of the Board of Directors

Our board of
directors has established the committees described below and may establish others from time to time.

Audit Committee.The members of our audit
committee are Messrs. Kiefel, McComas and Hanley. Mr. McComas took over as chair of the audit committee from Mr. Kiefel in October 2006. Our audit committee is responsible for:



| |  |  | the integrity of the financial reporting process and all other financial information published by the us;
| | - |  | ---------------------------------------------------------------------------------------------------------



| |  |  | the integrity of the our financial reporting system, including the management of risk and systems of internal control;
| | - |  | ----------------------------------------------------------------------------------------------------------------------



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| |  |  | our internal and external audit process, including appointing the external auditor and overseeing the independence of the external auditor; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our process for monitoring compliance with laws and regulations and our own Code of Conduct.
| | - |  | --------------------------------------------------------------------------------------------

Remuneration and Nomination Committee.The members of our remuneration and nomination committee are Mr. Hanley, Dr. Farrell and Dr. Villiger.
Ms. Smith served on the committee until her retirement. Dr. Robertson served on the committee until the appointment of Dr Villiger. Mr. Hanley chairs the committee. The purpose of our remuneration and nomination committee is:



| |  |  | monitor the ongoing development of the Board consistent with our growth and development;
| | - |  | ----------------------------------------------------------------------------------------



| |  |  | make recommendations for the appointment and removal of Directors to the Board;
| | - |  | -------------------------------------------------------------------------------



| |  |  | assist the Board evaluate the performance and contribution of individual directors, the Board and Board Committees; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------



| |  |  | assist the Board in establishing remuneration policies and practices that enable us to attract, retain and motivate executives and Directors who will pursue our
long-term growth and success.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Committees of the Board of Directors/Corporate Governance

We have adopted a Corporate Governance Framework. In preparing the framework, we have been mindful of the Principles of Good Corporate Governance and Best
Practice Recommendations issued by the Australian Securities Exchange Corporate Governance Council in March 2003. These recommendations are not mandatory, however departures from them are required to be fully disclosed in our annual report which is
sent to shareholders and publicly disclosed through the Australian Securities Exchange. The Board reviews and updates our Corporate Governance Framework as required and at least annually. The Pharmaxis Corporate Governance Framework was in
compliance with ASX Recommendations for the 2007 year.

The Sarbanes-Oxley Act of 2002, SEC Rules and the Nasdaq Global Market
Marketplace Rules. The Sarbanes-Oxley Act of 2002, as well as related new rules subsequently implemented by the SEC, require foreign private issuers, such as Pharmaxis, to comply with various corporate governance practices. In addition, Nasdaq
has made certain changes to its corporate governance requirements for companies that are listed on the Nasdaq Global Market. These changes allow us to follow Australian home country corporate governance practices in lieu of the otherwise
applicable Nasdaq corporate governance standards, as long as we disclose each requirement of Rule 4350 that we do not follow and describe the home country practice we follow in lieu of the relevant Nasdaq corporate governance standards. We intend to
take all actions necessary for Pharmaxis to maintain compliance with applicable corporate governance requirements of the Sarbanes-Oxley Act of 2002, rules adopted by the SEC and listing standards of Nasdaq. We follow Australian corporate governance
practices in lieu of the corporate governance requirements of the Nasdaq Marketplace Rules in respect of:



| |  |  | Nasdaq requirement under Rule 4350(f) that a quorum consist of holders of 331/3% of the outstanding ordinary shares  The Listing Rules of Australian Securities Exchange do not have an express requirement that each issuer listed with Australian
Securities Exchange have a quorum of any particular number of the outstanding ordinary shares, but instead allow a listed issuer to establish its own quorum requirements. Our quorum is currently five persons who are entitled to vote. We believe this
quorum requirement is consistent with the requirements of the Australian Securities Exchange and is appropriate and typical of generally accepted business practices in Australia.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The Nasdaq requirements under Rules 4350(c)(1) and (2) relating to director independence, including the requirements that a majority of the board of directors
must be comprised of independent directors and that independent directors must have regularly scheduled meetings at which only independent directors are present  The Nasdaq and Australian Securities Exchange definitions of what constitute an
independent director are not identical and the requirements relating to the roles and obligations of independent directors are not identical. The Australian Securities Exchange, unlike Nasdaq, permits an
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | issuer to establish its own materiality threshold for determining whether a transaction between a director and an issuer affects the directors status
as independent and it does not require that a majority of the issuers board of directors be independent, as long as the issuer publicly discloses this fact. In addition, the Australian Securities Exchange does not require that the independent
directors have regularly scheduled meeting at which only independent directors are present. We believe that our board composition is consistent with the requirements of the Australian Securities Exchange and that it is appropriate and typical of
generally accepted business practices in Australia.
| | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The Nasdaq requirements under Rule 4350(d) (other than Rule 4350(d)(2)(A)(ii), which we will comply with) relating to the composition of the audit committee and the
audit committee charter  The Nasdaq and Australian Securities Exchange audit committee requirements are not identical. Moreover, differences in the requirements of Nasdaq and Australian Securities Exchange also arise because of the differences
in the definitions of who constitutes an independent director, as discussed above. Issuers listed on the Australian Securities Exchange are required under applicable listing standards to establish an audit committee consisting only of non-executive
directors, a majority of independent directors, an independent chair, and at least three members, and adopt a formal audit committee charter which sets out the roles and responsibilities, composition, structure and membership requirements of the
audit committee, or publicly disclose that it has not done so. We have an audit committee and audit committee charter that are consistent with the requirements of the Australian Securities Exchange and which we believe are appropriate and typical of
generally accepted business practices in Australia. We also comply and will continue to comply with Nasdaq Rule 4350(d)(3) relating to audit committees responsibilities and authority required by SEC Rule 10A-3(b)(2)-(5); and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The Nasdaq requirements under Rules 4350(c)(3) and (4) that compensation of an issuers officers must be determined, or recommended to the Board for
determination, either by a majority of the independent directors, or a compensation committee comprised solely of independent directors, and that director nominees must either be selected, or recommended for the Boards selection, either by a
majority of the independent directors, or a nominations committee comprised solely of independent directors  The Nasdaq compensation committee requirements are not identical to the Australian Securities Exchange remuneration and nomination
committee requirements. Moreover, differences in the requirements of Nasdaq and Australian Securities Exchange with respect to these committees also arise because of the differences in the definitions of what constitutes an independent director, as
discussed above. Issuers listed on the Australian Securities Exchange are required under applicable listing standards to establish a remuneration committee consisting of a majority of independent directors and an independent chairperson, or publicly
disclose that it has not done so. We have a remuneration and nomination committee that is consistent with the requirements of the Australian Securities Exchange and which we believe is appropriate and typical of generally accepted business practices
in Australia.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Remuneration Committee Interlocks and Insider Participation

As noted above, the remuneration and nomination committee of our board consists of Mr. Hanley, Dr. Farrell and Dr. Villiger (Dr. Robertson
was a member until the appointment of Dr. Villiger). None of our executive officers serve as a member of the board of directors or compensation committee of any entity that has one or more executive officers who serve on our board of directors
or compensation committee.



|D. | Employees
|-- | ---------

The table below presents certain information regarding
our employees and full time contractors as of June 30, 2005, 2006 and 2007, respectively.



|                                    |  |                |  |      |  |     
|----------------------------------- |  | -------------- |  | ---- |  | ----
|                                    |  | As of June 30,
|                                    |  | 2005           |  | 2006 |  | 2007
|Research and development  Sydney   |  | 11             |  | 22   |  | 27  
|Research and development  Canberra |  | 8              |  | 7    |  |    
|Manufacturing                       |  | 15             |  | 20   |  | 26  
|Commercial                          |  | 2              |  | 10   |  | 9   
|Administration                      |  | 5              |  | 6    |  | 6   
|                                    |  |                |  |      |  |     
|                                    |  | 41             |  | 65   |  | 68  
|                                    |  |                |  |      |  |     



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Our main office facility at Frenchs Forest, Sydney was established in November 2002. We also have a
research group of five based in North Ryde, Sydney, a commercial team of two based in the United Kingdom, and three sales staff based around Australia. Until December 2006 we also had a research group based at the Australian National University
(ANU), Canberra. Four of the Australian sales staff are contracted completely to Pharmaxis under a service agreement between a labor hire firm and Pharmaxis.

Each of our full time employees enter into an agreement with a term of employment of between two to three years at which time the employment can be extended with the agreement of the parties. We also engage casual
employees from time to time who enter into contracts of employment with us. We do not have any at will employees, as this concept is not customary in Australia. We may only terminate the employment of any of our employees in accordance
with the relevant employees contract of employment. Our standard contract of employment for full time and part time employees provides that we can terminate the employment of an employee without notice for serious misconduct or with between
one to three months notice without cause (as set out in the relevant employees contract of employment). Our standard contracts of employment for casual employees provide that we can terminate the employment of a casual employee without notice.
For a summary of the key terms of employment of each of our executive officers, see Item 6  Directors, Senior Management and Employees. Minimum notice periods may be prescribed for certain of our employees under applicable
Australian law. The notice periods in our contracts of employment are equal to or exceed the minimum requirements.

None of our full time
employees are represented by any collective bargaining unit. Our employees are subject to certain minimum standards and conditions of employment under Australian law.

We believe that we maintain good relations with all of our employees and contractors.



|E. | Share Ownership
|-- | ---------------

For information with respect to
our ordinary shares held by the persons listed above in Management  Directors and Executive Officers and options granted to them on our ordinary shares, see Item 7A and Item 6 - Directors, Senior Management and
Employees.

For a description of any arrangements involving employees in the capital of Pharmaxis, see Management 
Employee Option Plan.



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##### Table of Contents

|ITEM 7. | MAJOR SHAREHOLDERS AND RELATED PARTY TRANSACTIONS
|------- | -------------------------------------------------



|A. | Major Shareholders
|-- | ------------------

The following table presents
certain information regarding the beneficial ownership of our ordinary shares as of November 9, 2007 by the following persons:



| |  |  | each person known by us to be the beneficial owner of more than 5% of our ordinary shares;
| | - |  | ------------------------------------------------------------------------------------------



| |  |  | our executive officers;
| | - |  | -----------------------



| |  |  | our directors; and
| | - |  | ------------------



| |  |  | our executive officers and directors as a group.
| | - |  | ------------------------------------------------

Beneficial ownership is determined according to the rules of the Securities and Exchange Commission and generally means that a person has beneficial ownership of a security if he or she possesses sole or shared voting
or investment power of that security, and includes options that are exercisable within 60 days. Information with respect to beneficial ownership has been furnished to us by each director, executive officer or 5% or more shareholder, as the case may
be. Unless otherwise indicated, to our knowledge, each shareholder possesses sole voting and investment power over the shares listed, subject to community property laws where applicable. All holders of our ordinary shares have the same voting
rights.

The below table lists applicable percentage ownership based on 191,425,480 ordinary shares outstanding as of November 9,
2007. Options to purchase our ordinary shares that are exercisable within 60 days of November 9, 2007 are deemed to be beneficially owned by the persons holding these options for the purpose of computing percentage ownership of that person, but
are not treated as outstanding for the purpose of computing any other persons ownership percentage.

Unless otherwise indicated in
the footnotes to the table below, the address for each of the persons listed in the table below is c/o Pharmaxis Ltd, Unit 2, 10 Rodborough Road, Frenchs Forest, NSW 2086, Australia.



|                                                             |  |                            |  |                                 |  |                                  |  
|------------------------------------------------------------ |  | -------------------------- |  | ------------------------------- |  | -------------------------------- | -
|                                                             |  | Beneficial Ownership       |  |                                 | 
|Individual/Group                                             |  | SharesBeneficiallyOwned(1) |  | OptionsExercisablewithin 60Days |  | Percentage of Shares Outstanding |  
|5% Shareholders                                              |  |                            |  |                                 |  |                                  |  
|Orbis Global Equity Fund Limited (2)                         |  | 28,097,784                 |  |                                |  | 14.7                             | %
|ABN AMRO Bank N.V. (3)                                       |  | 15,656,831                 |  |                                |  | 8.2                              | %
|Acorn Capital Limited(8)                                     |  | 10,270,496                 |  |                                |  | 5.4                              | %
|Platypus Asset Management Pty Limited(9)                     |  | 9,642,436                  |  |                                |  | 5.1                              | %
|Executive Officers and Directors                             |  |                            |  |                                 |  |                                  |  
|Alan D. Robertson, Ph.D.(4)                                  |  | 2,292,500                  |  | 2,192,500                       |  | 1.2                              | %
|Brett Charlton, Ph.D.                                        |  | 868,750                    |  | 448,750                         |  | *                                |  
|John F. Crapper                                              |  | 437,000                    |  | 435,000                         |  | *                                |  
|Ian A. McDonald, Ph.D.                                       |  | 160,000                    |  | 160,000                         |  | *                                |  
|David M. McGarvey(5)                                         |  | 1,080,000                  |  | 1,035,000                       |  | *                                |  
|Gary J. Phillips                                             |  | 584,164                    |  | 577,164                         |  | *                                |  
|Denis M. Hanley(6)                                           |  | 1,884,661                  |  | 1,100,000                       |  | 1.1                              | %
|Peter C. Farrell, PhD                                        |  | 171,645                    |  | 70,000                          |  | *                                |  
|Charles P.H. Kiefel                                          |  | 258,957                    |  | 58,957                          |  | *                                |  
|Malcolm J. McComas(7)                                        |  | 369,999                    |  | 230,000                         |  | *                                |  
|John Villiger, Ph.D                                          |  | 50,000                     |  | 50,000                          |  | *                                |  
|All executive officers and directors as a group (11 persons) |  | 8,157,676                  |  | 6,357,707                       |  | 4.3                              | %

---

|* | Represents beneficial ownership of less than one percent of our outstanding ordinary shares.
|- | --------------------------------------------------------------------------------------------



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---

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|(1) | Includes ordinary shares issuable pursuant to options exercisable within 60 days of November 9,2007. The figures represent the amounts last notified to Pharmaxis unless
otherwise stated. The relevant shareholders may have acquired or disposed of share since the last notification that are not reflected. However, any such transaction that resulted in a change of one percent or greater would require the notification
of such to Pharmaxis.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | Consists of 11,597,784 ordinary shares and 1.1 million ADSs held by Orbis Global Equity Fund Limited and or companies associated with Orbis Global Equity Fund Limited.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | All of these shares are held of record by nominee and trustee companies on behalf of ABN AMRO Bank N.V. ABN AMRO Bank N.V. has sole voting and dispositive power over these shares.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | Includes 100,000 ordinary shares held by Dr. Robertsons spouse.
|--- | ----------------------------------------------------------------



|(5) | Includes 5,000 ordinary shares held by McGarvey Investments Pty Ltd., of which Mr. McGarveys spouse is the sole director and shareholder. Mr. McGarvey disclaims
beneficial ownership over the shares held by McGarvey Investments Pty Ltd.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(6) | Includes 201,333 ordinary shares held partially by a trust and partially by a superannuation fund of which Mr. Hanley is a beneficiary. Also includes 16,664 ordinary shares
held by Mr. Hanleys spouse.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(7) | Includes (i) 100,000 ordinary shares held by Movilli Pty Ltd, and (ii) 26,666 ordinary shares held by Bunyula Super Pty Ltd. Mr. McComas has shared voting and
dispositive power over the shares held by these two entities. Also includes 13,333 ordinary shares held by Mr. McComas spouse.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(8) | All of these shares are held of record by nominee and trustee companies on behalf of Acorn Capital Limited, in its capacity as discretionary investment manager to certain
superannuation funds, pooled superannuation trusts, managed investment schemes and investment management agreements. Acorn Capital Limited has sole voting and dispositive power over these shares.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(9) | All of these shares are held of record by Platypus Asset Management Pty Limited, in its capacity as discretionary investment manager to certain superannuation funds, pooled
superannuation trusts, managed investment schemes and investment management agreements. Platypus Asset Management has sole voting and dispositive power over these shares.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Significant Changes to Percentage Ownership of Principal Shareholders

The following table presents information with
respect to certain significant changes in percentage ownership of our ordinary shares held by beneficial holders of more than five percent of our ordinary shares since June 30, 2004.



|                   |  |            |     |  |                             |   |  |                                      |  
|------------------ |  | ---------- | --- |  | --------------------------- | - |  | ------------------------------------ | -
|5% Shareholder     |  | Date       |     |  | % ofSharesBeneficiallyOwned |   |  | Change in% ofSharesBeneficiallyOwned |  
|ABN AMRO Bank N.V. |  | 11/09/2007 | (1) |  | 8.2                         | % |  | 8.2                                  | %



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##### Table of Contents

|                                 |  |                |  |      |  |      |  
|-------------------------------- |  | -------------- |  | ---- |  | ---- | -
|Orbis Global Equity Fund Limited |  | 11/11/2005(3)  |  | 11.3 |  | 11.3 |  
|                                 |  | 10/31/2006(4)  |  | 12.3 |  | 1.0  |  
|                                 |  | 11/29/2006(5)  |  | 14.1 |  | 1.8  |  
|                                 |  | 11/09/2007(14) |  | 14.7 |  | 0.6  |  
|Acorn Capital Limited            |  | 11/10/2003(2)  |  | 3.0  |  | 3.0  |  
|                                 |  | 02/27/2004(6)  |  | 5.2  |  | 2.2  |  
|                                 |  | 06/24/2004(7)  |  | 6.2  |  | 1.0  |  
|                                 |  | 09/13/2004(8)  |  | 7.2  |  | 1.0  |  
|                                 |  | 11/11/2005(9)  |  | 5.6  |  | (1.6 | )
|                                 |  | 10/31/2006(10) |  | 5.5  |  | (0.1 | )
|                                 |  | 02/26/2007(11) |  | 5.0  |  | (0.5 | )
|                                 |  | 10/31/2006(12) |  | 5.4  |  | 0.4  |  
|Platypus Asset Management        |  | 11/09/2007(13) |  | 5.0  |  | 5.0  |  

---

|(1) | After giving effect to the purchase of 15,656,831 shares in private transactions and an Australian private placement in October 2007
|--- | ------------------------------------------------------------------------------------------------------------------------------------



|(2) | After giving effect to shares purchased by the listed entity as part of the initial public offering of our ordinary shares on the Australian Securities Exchange in November 2003.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | After giving effect to shares issued by the listed entity as part of the US public offering of our ADS and Australian private placement of our ordinary shares in November 2005.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | After giving effect to the purchase of 2,094,341 ordinary shares in private transactions from January 1, 2006 to November 3, 2006.
|--- | ----------------------------------------------------------------------------------------------------------------------------------



|(5) | After giving effect to the purchase of 3,067,973 ordinary shares in private transactions on November 29, 2006.
|--- | --------------------------------------------------------------------------------------------------------------



|(6) | After giving effect to (i) 3,200,000 ordinary shares purchased by Acorn Capital Limited as part of the initial public offering of our ordinary shares on the Australian Stock
Exchange in November 2003 and (ii) 2,377,359 ordinary shares purchased in private transactions from September 24, 2003 to February 27, 2004.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(7) | After giving effect to the purchase of 1,109,441 ordinary shares in private transactions from March 1, 2004 to June 24, 2004.
|--- | -----------------------------------------------------------------------------------------------------------------------------



|(8) | After giving effect to the purchase of 1,130,559 shares in private transactions from June 28, 2004 to September 13, 2004.
|--- | -------------------------------------------------------------------------------------------------------------------------



|(9) | After giving effect to the issue of shares by the company in November 2005 in its US public offering and Australian private placement, and after giving effect to the purchase of
1,933,573 ordinary shares on October 1, 2004
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(10) | After giving effect to the issue of shares by the company in the period November 12, 2005 to October 31, 2006 subsequent to the exercise of options granted under the
Pharmaxis Employee Option Plan.
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(11) | After giving effect to the sale of 892,173 ordinary shares in private transactions from January 2006 to February 2007.
|---- | ----------------------------------------------------------------------------------------------------------------------



|(12) | After giving effect to the purchase of 1,411,737 shares in private transactions from February 2007 to November 2007 and an Australian private placement in October 2007
|---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(13) | After giving effect to the purchase of 9,642,436 shares in private transactions from November 2004 to November 2007.
|---- | --------------------------------------------------------------------------------------------------------------------



|(14) | After giving effect to the purchase of 3,169,470 shares in private transactions from February 2007 to November 2007 and an Australian private placement in October 2007.
|---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We are not aware of any other significant changes in percentage ownership with respect to our principal shareholders
resulting from their respective purchases or sales of our ordinary shares.

Our major shareholders do not have different voting rights.

As of October 31, 2007, half a percent of our ordinary shares were held in the United States by ten holders of record, and 99% of our
ordinary shares were held in Australia by 5,329 holders of record.

As of October 31, 2007, 1,259,639 ADSs, representing 18,894,585
ordinary shares, were outstanding in the United States, all of which were held of record by Cede & Co.



|B. | Related Party Transactions
|-- | --------------------------

Transactions

There are no related party transactions except as follows:

Stock Options
Granted to Executive Officers and Directors

See Item 6 - Directors, Senior Management and Employees.



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##### Table of Contents

Employment Agreements

We have entered into employment agreements with our executive officers. For more information regarding these agreements, see Item 6 - Directors, Senior Management and Employees.

Director Indemnification

We have on various dates entered into Deeds
of Access to Documents and Indemnity agreements with certain executive officers and each of our directors. See Item 6 - Directors, Senior Management and Employees.



|C. | Interests of Experts and Counsel
|-- | --------------------------------

Not Applicable.



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##### Table of Contents

|ITEM 8. | FINANCIAL INFORMATION
|------- | ---------------------



|A. | Consolidated Statements and Other Financial Information
|-- | -------------------------------------------------------

Our financial statements are included as Item 18 of this registration statement on Form 20-F.

Legal Proceedings

We are not involved in any significant legal, arbitration or governmental proceedings. We are not aware of any pending significant legal, arbitration
or governmental proceedings with respect to the Company.

Dividend Policy

We have never declared or paid any cash dividends on our ordinary stock and we do not anticipate paying any cash dividends in the foreseeable
future. Dividends may only be paid out of our profits. Payment of cash dividends, if any, in the future will be at the discretion of our board of directors or, if our directors do not exercise their power to issue dividends, our
shareholders in a general meeting may exercise the powers. See Item 10. Additional Information  B. Constitution Dividends.



|B. | Significant Changes
|-- | -------------------

None



|ITEM 9. | THE OFFER AND LISTING
|------- | ---------------------



|A. | Offer and Listing Details  Price History
|-- | -----------------------------------------

Ordinary Shares

The following tables present, for the periods indicated, the high and low market prices for our ordinary shares reported on the
Australian Securities Exchange since November 10, 2003, the date on which our ordinary shares were initially quoted. Prior to the initial quotation of our ordinary shares on the Australian Securities Exchange on November 10, 2003, our
ordinary shares were not regularly traded in any organized market and were not liquid.



|                 |  |                                         |  |     |       |    |   |      
|---------------- |  | --------------------------------------- |  | --- | ----- | -- | - | -----
|                 |  | High                                    |  | Low
|                 |  |                                         |  | A$  |       | A$
|Fiscal Year 2004 |  | From November 10, 2003 to June 30, 2004 |  | $   | 0.570 |    | $ | 0.340
|Fiscal Year 2005 |  | Full Year                               |  |     | 1.850 |    |   | 0.485
|Fiscal Year 2006 |  | First Quarter                           |  |     | 2.970 |    |   | 1.530
|                 |  | Second Quarter                          |  |     | 3.280 |    |   | 1.750
|                 |  | Third Quarter                           |  |     | 2.560 |    |   | 1.780
|                 |  | Fourth Quarter                          |  |     | 2.560 |    |   | 1.710
|                 |  | Full Year                               |  |     | 3.280 |    |   | 1.530
|Fiscal Year 2007 |  | First Quarter                           |  |     | 2.440 |    |   | 1.680
|                 |  | Second Quarter                          |  |     | 3.450 |    |   | 2.210
|                 |  | Third Quarter                           |  |     | 3.660 |    |   | 2.920
|                 |  | Fourth Quarter                          |  |     | 3.630 |    |   | 3.120
|                 |  | Full Year                               |  |     | 3.660 |    |   | 1.680



81



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|                                       |  |       |  |      
|-------------------------------------- |  | ----- |  | -----
|Fiscal 2008 (through November 9, 2007) |  | 4.530 |  | 3.050
|Most Recent Six Months                 |  |       |  |      
|May 2007                               |  | 3.600 |  | 3.120
|June 2007                              |  | 3.560 |  | 3.130
|July 2007                              |  | 3.590 |  | 3.110
|August 2007                            |  | 4.120 |  | 3.050
|September 2007                         |  | 4.300 |  | 3.820
|October 2007                           |  | 4.450 |  | 3.840

American Depositary Shares (ADS)

The following tables present, for the periods indicated, the high and low market prices for our ADSs as reported on the Nasdaq Global Market since
August 29, 2005, the date on which our ADSs were initially quoted. Prior to the initial quotation of our ADSs on the Nasdaq Global Market on August 29, 2005, our ADSs were not regularly traded in any organized market and were not liquid.



|                                       |  |                                       |        |       |        |        |   |       
|-------------------------------------- |  | ------------------------------------- | ------ | ----- | ------ | ------ | - | ------
|                                       |  | High                                  |        | Low  
|                                       |  |                                       |        | U.S.$ |        | U.S.$ 
|Fiscal Year 2006                       |  | First Quarter (from August 29, 2005)  |        | $     | 34.060 |        | $ | 19.440
|                                       |  | Second Quarter                        |        |       | 35.980 |        |   | 21.550
|                                       |  | Third Quarter                         |        |       | 28.000 |        |   | 20.500
|                                       |  | Fourth Quarter                        |        |       | 29.000 |        |   | 20.000
|                                       |  | From August 29, 2005 to June 30, 2006 |        |       | 35.980 |        |   | 19.440
|Fiscal Year 2007                       |  | First Quarter                         |        |       | 25.800 |        |   | 19.440
|                                       |  | Second Quarter                        |        |       | 43.250 |        |   | 24.180
|                                       |  | Third Quarter                         |        |       | 42.500 |        |   | 35.000
|                                       |  | Fourth Quarter                        |        |       | 46.400 |        |   | 36.000
|                                       |  | Full Year                             |        |       | 46.400 |        |   | 19.440
|Fiscal 2008 (through November 9, 2007) |  |                                       | 62.50  |       |        | 35.510
|Most Recent Six Months                 |  |                                       |        |       |        |       
|May 2007                               |  |                                       | 43.130 |       |        | 39.000
|June 2007                              |  |                                       | 46.400 |       |        | 36.000
|July 2007                              |  |                                       | 47.500 |       |        | 40.500
|August 2007                            |  |                                       | 47.980 |       |        | 35.510
|September 2007                         |  |                                       | 54.700 |       |        | 47.150
|October 2007                           |  |                                       | 60.700 |       |        | 52.000



|B. | Plan of Distribution
|-- | --------------------

Not applicable.



|C. | Markets
|-- | -------

Our ordinary shares are traded on the
Australian Securities Exchange Ltd. and are traded on the Nasdaq Global Market.



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##### Table of Contents

|D. | Selling Shareholders
|-- | --------------------

Not applicable.



|E. | Dilution
|-- | --------

Not applicable.



|F. | Expenses of the Issue
|-- | ---------------------

Not applicable.



|ITEM 10. | ADDITIONAL INFORMATION
|-------- | ----------------------



|A. | Description of Share Capital
|-- | ----------------------------

Not applicable



|B. | Constitution
|-- | ------------

Our constituent document is a
Constitution. Our Constitution does not provide for or prescribe any specific objects or purposes of the Company. Our Constitution is subject to the terms of the Listing Rules of the Australian Securities Exchange and the Corporations Act 2001. Our
Constitution may be amended or repealed and replaced by special resolution of shareholders, which is a resolution passed by at least 75% of the votes cast by shareholders entitled to vote on the resolution.

Shareholders Meetings

We must hold an annual general
meeting within five months of the end of each fiscal year. Our end of fiscal year is currently June 30 each year. At the annual general meeting, shareholders typically consider the annual financial report, directors report and auditors
report and vote on matters, including the election of directors, the appointment of the auditor and fixing the non-executive directors and auditors remuneration. We may also hold other meetings of shareholders from time to time. The
annual general meeting must be held in addition to any other meetings which we may hold.

A director or the board of directors may call and
arrange a meeting of shareholders, when and where they decide. The directors must call a meeting of shareholders when requested by shareholders who hold at least 5% of the votes that may be cast at the meeting or at least 100 members who are
entitled to vote at the meeting or as otherwise required by the Corporations Act 2001. Shareholders with at least 5% of the votes in Pharmaxis may also call a general meeting at their own cost.

At least 28 calendar days notice must be given of a meeting of shareholders. A meeting of shareholders may be called on shorter notice if, in respect of
the annual general meeting, all of the shareholders agree beforehand, or in respect of any other meeting of shareholders, if 95% of the shareholders agree beforehand.

Directors, auditors, shareholders, proxies, and attorneys and representatives of shareholders are entitled to attend general meetings. We may refuse admission to the meeting to anyone (other than a director) in
accordance with our Constitution and applicable Australian law. For the purpose of determining who is a shareholder at a particular meeting, the directors will determine that shareholders at a specified time (typically this will be 48 hours before
the meeting) are taken to be shareholders at the meeting.

The necessary quorum for a meeting of shareholders is five shareholders entitled
to vote. We believe this quorum requirement is consistent with common practice for many listed Australian publicly listed companies.

Unless applicable law or our Constitution requires a special resolution, a resolution of shareholders is passed if more than 50% of the votes cast by shareholders entitled to vote are cast in favor of the resolution. A special resolution is
passed if the notice of meeting sets out the intention to propose the special resolution and states



83



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##### Table of Contents

the resolution and it is passed by at least 75% of the votes cast by shareholders entitled to vote on the resolution. A special resolution usually
involves more important questions affecting Pharmaxis as a whole or the rights of some or all of our shareholders. Special resolutions are required in a variety of circumstances under our Constitution and the Corporations Act 2001, including without
limitation:



| |  |  | to change our name;
| | - |  | -------------------



| |  |  | to amend or repeal and replace our Constitution;
| | - |  | ------------------------------------------------



| |  |  | to approve the terms of issue of preference shares;
| | - |  | ---------------------------------------------------



| |  |  | to approve the variation of class rights of any class of shareholders;
| | - |  | ----------------------------------------------------------------------



| |  |  | to convert one class of shares into another class of shares;
| | - |  | ------------------------------------------------------------



| |  |  | to approve certain buy backs of shares;
| | - |  | ---------------------------------------



| |  |  | to approve a selective capital reduction of our shares;
| | - |  | -------------------------------------------------------



| |  |  | to approve Pharmaxis financially assisting a person to acquire shares in Pharmaxis;
| | - |  | -----------------------------------------------------------------------------------



| |  |  | to remove and replace our auditor;
| | - |  | ----------------------------------



| |  |  | to approve the transfer of our place of registration to registration under a law of another state or territory of Australia;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



| |  |  | to change our company type;
| | - |  | ---------------------------



| |  |  | with the leave of an authorized Australian court, to approve our voluntary winding up;
| | - |  | --------------------------------------------------------------------------------------



| |  |  | to confer on a liquidator of Pharmaxis either a general authority or a particular authority in respect of compensation arrangements of the liquidator; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | to approve an arrangement entered into between a company about to be, or in the course of being, wound up.
| | - |  | ----------------------------------------------------------------------------------------------------------

Shareholder Voting Rights

At a general meeting,
every shareholder present (in person or by proxy, attorney or representative) and entitled to vote has one vote on a show of hands. Every shareholder present (in person or by proxy, attorney or representative) and entitled to vote has one vote per
fully paid ordinary share on a poll. This is subject to any other rights or restrictions which may be attached to any shares. In the case of an equality of votes on a resolution at a meeting (whether on a show of hands or on a poll), the chairman of
the meeting has a deciding vote in addition to any vote that the chairman of the meeting has in respect of that resolution. A poll may be requested on any resolution by at least five shareholders entitled to vote on the resolution, by shareholders
holding at least 5% of the votes that may be cast on the resolution or by the chairman. The directors may, subject to the Corporations Act and the Listing Rules of the Australian Securities Exchange, determine that, at any general meeting or class
meeting, a shareholder who is entitled to attend and vote at that meeting is entitled to give their vote by way of a direct vote by giving written notice of their voting intention. The directors may specify the form, method and timing of giving a
direct vote at a meeting in order for the vote to be valid and the manner in which the direct vote will be carried out. Subject to any other rights or restrictions which may be attached to any shares, where the directors have approved the casting of
votes by direct vote, every shareholder having the right to vote on the resolution has one vote for each fully paid share they hold and a fraction of a vote for each partly paid share they hold.

The Listing Rules of the Australian Securities Exchange provide that the votes of certain shareholders must be disregarded in certain circumstances.
Generally, a shareholders vote may be disregarded if the person may benefit from the transaction that is the subject of the resolution (subject to certain exceptions, such as where the benefit is received in their capacity as a shareholder in
common with other shareholders). Without limitation, a shareholders vote may be disregarded in respect of:



84



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##### Table of Contents

| |  |  | the issue of shares or options, if the shareholder is entitled to acquire securities under the issue or has acquired securities under the issue (subject to a range
of exceptions including in respect of a pro-rata offer made to all shareholders) or is entitled to any other sort of benefit as a result of the issue (for example underwriting commissions);
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the amendment of the terms of options, if the shareholder holds the relevant options;
| | - |  | -------------------------------------------------------------------------------------



| |  |  | if the shareholder is a director, to approve an increase in the remuneration payable to the directors;
| | - |  | ------------------------------------------------------------------------------------------------------



| |  |  | if the shareholder is a director, in respect of termination benefits payable to directors;
| | - |  | ------------------------------------------------------------------------------------------



| |  |  | the acquisition or disposal of a substantial asset;
| | - |  | ---------------------------------------------------



| |  |  | the issue of securities to specified related parties or anyone else the Australian Securities Exchange considers should not be entitled to vote; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | significant transactions such as changes to the nature and scale of our operations or a change to our main undertaking.
| | - |  | -----------------------------------------------------------------------------------------------------------------------

The Australian Securities Exchange may also identify a person who in their view should not be entitled to vote.

Issue of Shares and Changes in Capital

Subject to
our Constitution, the Corporations Act 2001, the Listing Rules of the Australian Securities Exchange and any other applicable law, we may at any time issue shares and grant options or warrants on any terms, with preferred, deferred or other special
rights and restrictions and for the consideration and other terms that the directors determine. Our power to issue shares includes the power to issue bonus shares (for which no consideration is payable to Pharmaxis), preference shares (including
redeemable preference shares) and partly paid shares.

Subject to the requirements of our Constitution, the Corporations Act 2001, the
Listing Rules of the Australian Securities Exchange and any other applicable law we may:



| |  |  | consolidate or divide our share capital into a larger or smaller number by resolution passed by shareholders at a general meeting;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | may reduce our share capital by special resolution passed by at least 75% of the votes cast by shareholders entitled to vote on the resolution provided that the
reduction is fair and reasonable to our shareholders as a whole, and does not materially prejudice our ability to pay creditors;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | undertake an equal access buyback of our ordinary shares by ordinary resolution of shareholders (although if we have bought back less than 10% of our shares over
the period of the previous 12 months, shareholder approval may not be required); and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | undertake a selective buyback of certain shareholders shares by special resolution passed by at least 75% of the votes cast by shareholders entitled to vote
on the resolution, with no votes being cast in favor of the resolution by any person whose shares are proposed to be bought back or by their associates.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

In certain circumstances, including the division of a class of shares into further classes of shares, the issue of additional shares or the issue of a new class of shares, we may require the approval of any class of
shareholders whose rights are varied or are taken to be varied by special resolution of shareholders generally and by special resolution of the holder of shares in that class whose rights are varied or taken to be varied.

Dividends

Subject to any special rights or
restrictions attached to a share, we may pay dividends on our shares as the directors decide. Dividends may be only paid out of our profits.



85



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##### Table of Contents

Subject to any special rights or restrictions attached to a share, the directors may determine that a
dividend will be payable on a share and fix the amount, the time for payment and the method for payment. Dividends may be paid on shares of one class but not another and at different rates for different classes. If the board of directors does not
exercise their power to issue dividends, the shareholders in a general meeting may. Under our Constitution, a shareholder or shareholders holding the requisite number of shares required to convene a general meeting would be able to convene a meeting
or require the directors to convene a meeting to consider whether we should pay a dividend. The proposed resolution to pay the dividend would need to be included in the notice of meeting and would be voted on by shareholders as an ordinary
resolution. Any dividend payable would only be payable out of our profits.

Liquidation Rights

Subject to any special rights or restrictions attached to shares, on a winding up, all available assets must be repaid to the shareholders and any surplus
must be distributed among the shareholders in proportion to the number of fully paid shares held by them. For this purpose a partly paid share is treated as a fraction of a share equal to the proportion which the amount paid bears to the total issue
price of the share before the winding up began.

If we experience financial problems, the directors may appoint an administrator to take
over our operations to see if we can come to an arrangement with our creditors. If we cannot agree with our creditors, Pharmaxis may be wound up.

A receiver, or receiver and manager, may be appointed by order of a court or under an agreement with a secured creditor to take over some or all of the assets of a company. A receiver may be appointed, for example, because an amount owed to
a secured creditor is overdue.

We may be wound up by order of a court, or voluntarily if our shareholders pass a special resolution to do
so. A liquidator is appointed when a court orders a company to be wound up or the shareholders of a company pass a resolution to wind up the company. A liquidator is appointed to administer the winding up of a company.

Calls, Lien and Forfeiture in Respect of Partly Paid Shares

Subject to any special rights or restrictions attached to shares, the board of directors may make calls on the holder of a share for any unpaid portion of the issue price of that share at any time. The directors may make a call payable by
installments. If the amount called is not paid by the requisite time, the shareholder must pay Pharmaxis interest on the amount unpaid from the date the call becomes payable until and including the date of payment and our costs arising from the
non-payment. Joint holders of a share and their respective personal representatives are all jointly and severally liable to pay all calls on the share. The board of directors may recover an amount presently payable as a result of a call by suing the
shareholder for the debt, by enforcing the lien on the share or by declaring forfeit the share. The forfeiture of a share extinguishes the former shareholders interest in the share. We have a first ranking lien on each share registered to a
shareholder, dividends payable on a shares, proceeds on the sale of a share for an unpaid call or installment that is due but unpaid on the share, any amounts we are required by law to pay in respect of the shares of that shareholder, and in respect
of any interest and costs presently payable to Pharmaxis by the shareholder. We may sell a share to enforce a lien in certain circumstances.

We do not currently have any partly paid shares outstanding.

Limitations on Rights to Own Shares and ADSs

The Foreign Acquisitions and Takeovers Act 1975 regulates acquisitions of shares by non-Australian persons giving rise to substantial interests or
controlling interests in an Australian companies. Some of the relevant terms of the Foreign Acquisitions and Takeovers Act 1975 are summarized below.

In general terms, the Foreign Acquisitions and Takeovers Act 1975 prohibits a foreign interest from acquiring shares or entering into an agreement to acquire shares or interests in shares if, after the acquisition or
agreement, such foreign interest would hold a substantial interest or controlling interest in an Australian corporation, without first applying for approval by the Treasurer of the Australian Government and such approval being granted or 40 days
having elapsed after such application was made.



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For foreign investors other than U.S. investors, the notification obligation arises in relation to
proposals to acquire a substantial interest or controlling interest in an Australian business, the value of whose assets exceeds A$100 million or whose business is valued at over A$100 million. As of December 31, 2006, our business had a market
valuation of greater than A$100 million. In the case of U.S. investors, other than the U.S. government and other than when the investment proposal relates to investments in prescribed sensitive sectors, the requirement to notify the Australian
Government of a proposal to acquire a substantial interest or a controlling interest in an Australian business arises when the value of the assets of the relevant Australian business exceeds A$871 million or the value of the Australian business
exceeds A$871 million. A U.S. investor is defined as a national or permanent resident of the U.S., a U.S. enterprise, or a branch of an entity located in the U.S. and carrying on business activities in the U.S. As of December 31, 2006, we had
assets and a market value less than A$871 million and were not be regarded as a business in a sensitive sector.

A foreign
interest is defined, in summary, as:



| |  |  | a natural person not ordinarily resident in Australia;
| | - |  | ------------------------------------------------------



| |  |  | a company in which a natural person not ordinarily resident in Australia or a foreign company holds a substantial interest;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------



| |  |  | a company in which two or more persons, each of whom is either a natural person not ordinarily resident in Australia or a foreign company, hold an aggregate
substantial interest;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the trustee of a trust estate in which a natural person not ordinarily resident in Australia or a foreign company holds a substantial interest; or
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the trustee of a trust estate in which two or more persons, each of whom is either a natural person not ordinarily resident in Australia or a foreign company, hold
an aggregate substantial interest.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

In summary, a person is taken to hold a substantial interest in a company if:



| |  |  | the person, alone or together with any associate or associates of the person, is in a position to control not less than 15% of the voting power in the company or
holds legal or equitable interests in not less than 15% of the issued shares in the company; or
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | two or more persons are taken to hold an aggregate substantial interest in a company if they, together with any associate or associates of any of them, are in a
position to control not less than 40% of the voting power in the company or hold legal or equitable interests in not less than 40% of the issued shares in the company.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Where a person holds a substantial interest in a company or two or more persons hold an aggregate substantial interest in a company, that person will be
taken to hold a controlling interest in the company, or those persons will be taken to hold an aggregate controlling interest in the company, unless the Treasurer is satisfied that the person together with their associates (if any) are not in a
position to determine the policy of the company.

The Treasurer may make an order prohibiting a proposed acquisition of shares or all or
any of the proposed acquisitions. Where the Treasurer makes an order prohibiting a proposed acquisition of shares, it may also make an order in relation to a specified foreign person and their associates prohibiting those persons from acquiring
additional interests or voting rights in the company.

Where a person has acquired shares in a company, and the Treasurer is satisfied that
the acquisition has had the result that the company becomes controlled by foreign persons, or in the case of a company that was previously controlled by foreign persons, includes a person who is not one of the foreign persons forming part of the
existing foreign interest, and that result is contrary to Australias national interest, the Treasurer may make an order directing the person who acquired the shares to dispose of those shares within a specified time to any person or persons
approved in writing by the Australian government.

If a person or persons acquires shares or enters into an agreement to acquire shares or
interests which requires the approval of the Treasurer, but the person or persons fails to get approval, the person or persons are guilty of an offence and may be liable to penalties and imprisonment. Among other things, orders are able to be made
restraining the exercise of any rights attached to shares held by the foreign person or corporation and directing the disposal of shares.

Shareholders, potential shareholders and holders of ADSs and potential holders of ADSs are urged to get their own independent legal advice in relation to the application of the Foreign Acquisitions and Takeovers Act 1975.



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Change of Control

Corporations Act 2001

Takeovers of listed Australian public companies, such as Pharmaxis, are
regulated amongst other things by the Corporations Act 2001 which prohibits the acquisition of a relevant interest in issued voting shares in a listed company if the acquisition will lead to the persons or someone elses voting power in
the company increasing from 20% or below to more than 20% or increasing from a starting point that is above 20% and below 90%, subject to a range of exceptions.

A relevant interest is defined very broadly to capture most forms of interest in shares and would include interests in our ADSs. Generally, and without limitation, a person will have a relevant interest in securities
if they:



| |  |  | are the holder of the securities;
| | - |  | ---------------------------------



| |  |  | have power to exercise, or control the exercise of, a right to vote attached to the securities; or
| | - |  | --------------------------------------------------------------------------------------------------



| |  |  | have power to dispose of, or control the exercise of a power to dispose of, the securities (including any indirect or direct power or control).
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------

It does not matter how remote the relevant interest is or how it arises. If two or more people can jointly exercise one
of these powers, each of them is taken to have that power.

If at a particular time a person has a relevant interest in issued securities
and the person:



| |  |  | has entered or enters into an agreement with another person with respect to the securities;
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | has given or gives another person an enforceable right, or has been or is given an enforceable right by another person, in relation to the securities; or
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | has granted or grants an option to, or has been or is granted an option by, another person with respect to the securities,
| | - |  | --------------------------------------------------------------------------------------------------------------------------

and the other person would have a relevant interest in the securities if the agreement were performed, the right enforced or the option exercised, the other person is
taken to already have a relevant interest in the securities.

A person will also be regarded as having a relevant interest in voting shares
in a company if the non-voting securities in which the person already had a relevant interest become voting shares in the company or there is an increase in the number of votes that may be cast on a poll attached to voting shares that the person
already had a relevant interest in. In these circumstances, the acquisition of the relevant interest will occur when the securities become voting shares or the number of votes increases.

There are a number of exceptions to the prohibition on acquiring a relevant interest in issued voting shares in a listed company if the acquisition will
lead to the persons or someone elses voting power in the company increasing from 20% or below to more than 20% or increasing from a starting point that is above 20% and below 90%. In general terms, some of the more significant exceptions
include:



| |  |  | when the acquisition results from the acceptance of an offer under a formal takeover bid;
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | when the acquisition is conducted on market by or on behalf of the bidder under a takeover bid and the acquisition occurs during the bid period;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | when shareholders of the company approve the takeover by resolution passed at general meeting;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | an acquisition by a person if, throughout the 6 months before the acquisition, that person, or any other person, has had voting power in the company of at least 19%
and as a result of the acquisition, none of the relevant persons would have voting power in the company more than 3 percentage points higher than they had 6 months before the acquisition;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | as a result of a rights issue;
| | - |  | ------------------------------



| |  |  | as a result of dividend reinvestment schemes;
| | - |  | ---------------------------------------------



| |  |  | as a result of underwriting arrangements;
| | - |  | -----------------------------------------



| |  |  | through operation of law;
| | - |  | -------------------------



| |  |  | an acquisition which arises through the acquisition of a relevant interest in another listed company;
| | - |  | -----------------------------------------------------------------------------------------------------



| |  |  | arising from an auction of forfeited shares; or
| | - |  | -----------------------------------------------



| |  |  | arising through a compromise, arrangement, liquidation or buyback.
| | - |  | ------------------------------------------------------------------

Breaches of the takeovers provisions of the Corporations Act 2001 are criminal offences. The Australian Securities and Investments Commission and the Australian Takeover Panel have a wide range of powers relating to
breaches of takeover provisions including the ability to make orders canceling contracts, freezing transfers of, and rights attached to, securities, and forcing a party to dispose of securities. There are certain defenses to breaches to the
takeovers provisions provided in the Corporations Act 2001.

Proportional Takeover

Our Constitution contains what is known as a proportional takeover provision which provides that the registration of transfers giving effect to a takeover
for only a specified proportion of Pharmaxis is prohibited until a resolution to approve the bid is passed by shareholders of the bid class of securities. The resolution is passed if the proportion of bid class shareholders accepting the resolution
is greater than 50%. The proportional takeover provision in our Constitution expires every three years. At our annual general meeting on October 26, 2006 shareholders approved the renewal of the proportional takeover provision in our
Constitution until October 26, 2009. Shareholders may prior to or after that time again renew the applicability of the proportional takeover provision at a general meeting.

Disclosure of Interests

The Corporations Act 2001 requires that a person must give notice to
Pharmaxis in the prescribed form within two business days (or in some cases by the next business day) if:



| |  |  | the person begins to have, or ceases to have, a substantial holding in Pharmaxis. A substantial holding will arise if a person and their associates have a relevant
interest in 5% or more of the votes in Pharmaxis or the person has made a takeover bid for the voting shares in Pharmaxis;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | if the person has a substantial holding in Pharmaxis and there is a movement of 1% in their holding; or
| | - |  | -------------------------------------------------------------------------------------------------------



| |  |  | if the person makes a takeover bid for Pharmaxis.
| | - |  | -------------------------------------------------

For the purposes of the notification obligation, a relevant interest in the voting shares is defined very broadly to capture most forms of interests in shares and would include interests in our ADSs. Generally, a
person will have a relevant interest in securities if such person is the holder of the securities, has power to exercise, or control the exercise of, a right to vote attached to the securities or has power to dispose of, or control the exercise of a
power to dispose of, the securities (including any indirect or direct control or power). Likewise, associates are defined broadly and includes:



| |  |  | corporate entities owned or controlled by the person;
| | - |  | -----------------------------------------------------



| |  |  | corporate entities that control the person;
| | - |  | -------------------------------------------



| |  |  | corporate entities that are controlled by an entity which controls the person;
| | - |  | ------------------------------------------------------------------------------



| |  |  | persons with whom the person has or proposes to enter into agreements with which relate to the composition of our board; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



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| |  |  | persons with whom the person is acting or is proposing to act in concert.
| | - |  | -------------------------------------------------------------------------

The rights attaching to our shares for non-compliance with the disclosure of interest requirements may result in disenfranchisement, loss of entitlement
to dividends and other payments and restrictions on transfer. A person who contravenes these obligations is liable to compensate a person for any loss or damage the person suffers because of the contravention.



|C. | Material Contracts
|-- | ------------------

Following is a summary of our
material contracts, other than contracts entered into in the ordinary course of business, to which we are a party, for the two years immediately preceding the filing of this document.

License Agreement with the Sydney South West Area Health Service

On October 10, 2001, we entered into a license agreement with Sydney South West Area Health Service. Pursuant to the license agreement, Sydney South West Area Health Service grants us an exclusive, worldwide
license, which is able to be sublicensed, to exploit certain key intellectual property and patents relating to the use of respirable dry powders for the assessment of bronchial hyper-responsiveness, a condition consistent with active asthma, for
monitoring steroid use in asthma patients, and for the management of diseases such as cystic fibrosis, bronchiectasis and chronic bronchitis.

There is no fixed expiry date for the license agreement. The term of the license in each relevant country is for the longer of 10 years from the first commercial sale of products which exploits the Sydney South West Area Health Service
intellectual property in that country or until the expiry of the last registered patent in that country. The license may be terminated earlier by either party if there is a breach of the agreement by a party and that party fails to remedy the breach
within 30 days after receiving notice to do so, or if any party becomes insolvent or if we determine in our commercial judgment that it is not prudent to continue the license. If we decide not to obtain product approval in any country, we will not
unreasonably refuse to convert the license into a non-exclusive license for that country.

We must bear the cost of maintaining the
relevant registered Sydney South West Area Health Service intellectual property and must use our reasonable commercial endeavors to exploit and undertake research and development of the intellectual property.

We may at our own cost prosecute applications for any new patentable inventions arising in the course of exploiting the Sydney South West Area Health
Service intellectual property, in our name. If we do not seek patent protection for the new patentable invention in any country, Sydney South West Area Health Service may at its own cost file patent applications.

For the term of the license, we are liable to pay the royalties described below to Sydney South West Area Health Service on the net sales of products and
services which exploit the Sydney South West Area Health Service intellectual property.

In respect of the upper and lower airway function
test application of the intellectual property:



| |  |  | no royalties until aggregate net sales of products and services from all countries of A$500,000 have been achieved;
| | - |  | -------------------------------------------------------------------------------------------------------------------



| |  |  | a royalty of 4% of the gross margin if the net sales of the products or services by us achieve a gross margin of 20% or less;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------



| |  |  | a royalty of 8% of the gross margin if the net sales of the products or services by us achieve a gross margin between 20% and 40%;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | a royalty of 10% of the gross margin if the net sales of the products or services by us achieve a gross margin greater than 40%; and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------



| |  |  | 20% of any royalty received from any sub-licensee.
| | - |  | --------------------------------------------------



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In respect of the mucociliary clearance and sputum induction applications of the intellectual property:



| |  |  | no royalties are payable until sales representing a gross margin of A$1 million have been achieved then, when the gross margin achieved by the product sales is
between A$1 million and A$25 million a royalty equal to 3% of the gross margin will apply, when it is between A$25 million and A$75 million a royalty equal to 2.5% of the gross margin will apply and when it is greater than A$75 million a royalty
equal to 2% of the gross margin will apply; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | 20% of any royalty received from a sub-licensee.
| | - |  | ------------------------------------------------

To date, we have not paid Sydney South West Area Health Service any royalty or license fees. We are not able to accurately estimate the aggregate amount of potential payments that may be due to Sydney South West Area
Health Service as this amount will be a function of the future sales of our applicable products and the percentage royalty and license fees set out above.

We have agreed to indemnify Sydney South West Area Health Service against all loss and damage that Sydney South West Area Health Service may sustain or incur as a result of any actions, claims, suits, proceedings or
demands arising directly or indirectly out of the breach of the license by us. Both parties have agreed to indemnify the other party against all loss and damage that the other party may sustain or incur as a result of any damage to the other
partys property or injury to or death of any of the other partys personnel arising out of the agreement.

Subject to a policy
being available on commercially reasonable terms, we must maintain a product liability insurance policy naming Sydney South West Area Health Service, both during the term of the agreement and for a period of six years after the termination of the
agreement.

License Agreement with ANU Enterprises Pty Ltd

On October 14, 1999, we entered into a license agreement with ANU Enterprises Pty Ltd (formerly called Anutech Pty Ltd). Pursuant to the license
agreement, ANU Enterprises Pty Ltd, as agent for the Australian National University, grants us an exclusive, worldwide license, with the right to sub-license, to exploit intellectual property and patents relating to the use of phosphosugars and
their analogues as anti-inflammatory agents in the field of ethical therapeutics. PXS25/64 is not covered by patents that are the subject of this agreement. We have granted to ANU Enterprises Pty Ltd a royalty-free non-exclusive license to use the
intellectual property and patents licensed to us and any of our improvements to that intellectual property for their internal research purposes.

There is no fixed expiry date for the license agreement. The term of the license agreement in respect of each patent is for the life of each of the licensed patents. The license may be terminated earlier for breach of the agreement if the
defaulting party fails to remedy a breach under the agreement within 90 days of receipt of written notice from the other party (or such longer period as may be agreed), or if the default is not capable of being remedied and the defaulting party does
not agree to pay compensation for the loss being suffered as a result of the breach. The non-defaulting party may terminate the agreement if one party defaults in the payment of any money due and the defaulting party fails to remedy the breach
within 30 days of receipt of notice from the non-defaulting party. The license agreement may also be terminated by one party if the other party becomes insolvent.

We must use our reasonable endeavors to exploit the intellectual property and licensed patents which are the subject of the agreement and have agreed to commence the sale of products which incorporate or arise from
the whole or partial use of the intellectual property and licensed patents by 2011.

Any new intellectual property acquired or developed by
us during the term of and in connection with the agreement is our property. ANU Enterprises Pty Ltd must advise us of the filing of any patent application or the issue of any patent which is legally or beneficially owned by the Australian National
University or ANU Enterprises Pty Ltd which dominates or is dominated by the licensed patents or relates to the product arising wholly or partially from the intellectual property or licensed patents. For a period of three months after notification
of any such intellectual property, we have the option of having any such intellectual property licensed to us under the agreement without any change to the royalty rate payable.

We must reimburse ANU Enterprises Pty Ltd for the costs incurred in filing, maintaining and renewing the Australian National Universitys
intellectual property. A royalty of 2% of revenue (net of expenses) received by us



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in connection with its use of the intellectual property and licensed patents is payable by us to ANU Enterprises Pty Ltd. The obligation to pay the royalty
survives termination of the agreement. To date, we have reimbursed ANU Enterprises Pty Ltd for certain patents costs and expenses but have not paid any royalties. We are not able to accurately estimate the aggregate amount of potential payments that
may be due to ANU Enterprises Pty Ltd as this amount will be a function of the future sales of our applicable products (if any) and the percentage of royalty payments set out above.

We have agreed to indemnify the Australian National University and ANU Enterprises Pty Ltd and any of their directors, officers, employees, staff,
students and agents against all loss, liability, damage, claim, cost and expense arising from or in connection with, amongst other things, breach by us of the agreement or our use of the intellectual property and licensed patents.

We must maintain a product liability insurance policy in respect of products related to the agreement.

AusIndustry P3 Pharmaceuticals Partnerships Program Funding Deed

On August 12, 2004, we entered into a funding deed with the Commonwealth of Australia under the AusIndustry P3 Pharmaceuticals Partnerships Program. The term of the funding deed is until June 30, 2008.
Subject to us expending certain eligible expenditure and undertaking certain eligible activities in connection with projects for the development of new treatments for autoimmune diseases (multiple sclerosis and rheumatoid arthritis) and the
development of new treatments for chronic respiratory disease, the Commonwealth of Australia may, as of June 30, 2007, pay us a total amount of A$0.9 million between July 2007 and June 2008 for eligible pharmaceutical research and development
activities undertaken by us in relation to the development of new treatments for autoimmune diseases and the development of new treatments for chronic respiratory diseases. As at June 30, 2007, we have received A$2,803,000 under the funding
deed.

Payments are made under the funding deed depending on the amount of eligible expenditure forecasted and actually made by us. Payment
amounts are limited to specified amounts each year which may be increased or decreased in accordance with the terms of the funding deed. The amount to be paid under the funding agreement is reduced by other financial assistance received from the
Commonwealth of Australia or any Australian state governments.

We are not entitled to funds under the funding agreement if the
Commonwealth of Australia has insufficient funding for the program, if we fail to submit reports when required, if we have not otherwise complied with our obligations under the funding agreement or if the Commonwealth of Australia is entitled to
terminate the deed. The Commonwealth of Australia may withhold payment if it considers that we are not entitled to the payment under the deed, for such time as the Commonwealth of Australia requires to make inquiries to determine whether we are
entitled to payment. We may be required to repay the amount of any overpayment of the grant if the Commonwealth of Australia gives us notice that they have paid us more than we are entitled to be paid.

The Commonwealth of Australia does not assert any ownership of, or any right to, any of the intellectual property created under the funding deed. We have
granted to the Commonwealth of Australia a permanent, irrevocable, royalty free, worldwide, non-exclusive license to use, reproduce, publish, transmit, adapt and modify any documents and associated materials brought into existence for the purpose of
us reporting on the performance of our obligations under the deed or otherwise used in connection with the grant program. This licensed material may only be used for the purposes of the Commonwealth of Australias dissemination, reporting and
accountability requirements, but not to commercially exploit such material.

We must provide a range of reports, including quarterly,
annual and ad-hoc reports and must respond to requests for information, in relation to the performance of our obligations under the funding deed to the Commonwealth of Australia. We must also provide the Commonwealth with audited financial
statements verifying actual expenditure. The Commonwealth of Australia is entitled to undertake assessments and reviews of our performance of our obligations at stipulated times under the funding deed and also on an ad-hoc basis.

The funding deed terminates on the earliest of the following:



| |  |  | June 30, 2008;
| | - |  | --------------



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| |  |  | if we enter into a new funding deed with the Commonwealth of Australia in relation to the research and development;
| | - |  | -------------------------------------------------------------------------------------------------------------------



| |  |  | if we agree with the Commonwealth of Australia to terminate the funding deed; and
| | - |  | ---------------------------------------------------------------------------------



| |  |  | if the Commonwealth of Australia has paid the maximum amounts to be paid under the deed.
| | - |  | ----------------------------------------------------------------------------------------

The Commonwealth of Australia may terminate the funding deed:



| |  |  | if the Commonwealth of Australia gives us not less than 30 days written notice of termination;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | if we are in breach of the funding deed and in the opinion of the Commonwealth of Australia the breach is not capable of being remedied or if capable of being
remedied it is not remedied within 21 days of receipt of written notice;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | in certain circumstances, if we fail to submit reports;
| | - |  | -------------------------------------------------------



| |  |  | if our research and development activities or the quality of those activities do not satisfy the grant eligibility criteria;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



| |  |  | if there is a change of control of us; or
| | - |  | -----------------------------------------



| |  |  | if we become insolvent.
| | - |  | -----------------------

Research
and Development Start Program Grant Agreement

On June 17, 2003, we entered into a grant agreement with the Commonwealth of
Australia under the research and development Start Grant Program. The Commonwealth of Australia has provided us with a grant of 50% of our eligible expenditure on a project for the development of a new treatment for cystic fibrosis up to a maximum
grant amount of A$3.0 million payable over the period to December 31, 2005. At June 30, 2006, we had received the aggregate maximum of A$3.0 million. The grant agreement formally terminates on December 31, 2010. We have ongoing
reporting obligations beyond the project completion date until the termination of the grant agreement.

We must use our best endeavors to
commercialize the project for the development of a new treatment for cystic fibrosis on normal commercial terms within a reasonable time of completion of the project. We must provide reports to the Commonwealth of Australia in the first, third and
fifth years after the completion of the grant funding which occurred in December 2005.

The Commonwealth of Australia may terminate the
grant agreement for breach of the agreement by us, for a failure by us to undertake the required research, if there is a change of control of us, or on the grounds of our insolvency. In certain limited circumstances where we fail to use our best
endeavors to commercialize the project within a reasonable time of completion of the project or upon termination of a grant due to our breach of agreement or our insolvency, the Commonwealth of Australia may require us to repay some or all of the
grant. We consider that the likelihood of being required to repay grant funding is remote while we continue to act in good faith with respect to this grant. We may be required to repay the amount of any overpayment of the grant if the Commonwealth
of Australia gives us notice that they have paid us more than we are entitled to be paid. To date, we have not been required to repay any amounts paid to us under our current two grant agreements and we are not aware of any current circumstances
that would require us to repay any such amounts.

Put and Call Option Deed

On 31 October 2007, we entered into a put and call option deed with GE Real Estate Investments Australia Pty Limited (GE) and Goodman
Property Services (Aust) Pty Limited (Goodman). Pursuant to the put and call option deed, Goodman has agreed to construct a custom designed facility on land which is owned by GE and located in Frenchs Forest, Sydney Australia. We have
the right to exercise a call option during a specified option exercise period to require GE and us to enter into a lease with respect to the new facility. Likewise, GE have the right to exercise a put option during a specified option exercise period
to require GE and us to enter into a lease with respect



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to the new facility. The terms of the lease are an annexure to the put and call option deed and take effect and become legally binding upon exercise of the
option by either GE or us.

The put and call option deed sets out the obligations of Goodman and us with respect to the construction of the
new facility, including the standards to which the works must be undertaken, the specifications for the works and the process for varying those specifications and the schedule of works and the manner in which the schedule of works may be varied. A
project control group with representatives of GE, Goodman and us has been established to oversee the project.

We have agreed to release GE
and Goodman from liability for injury, death or loss arising in connection with the deed except to the extent such claims were caused by GE or Goodman. We have indemnified GE and Goodman against all claims for which GE or Goodman suffer which are
caused or contributed to by any willful or negligent act or omission by us, any default by us under the deed, the carrying out of work by us or the use of the land by us, except to the extent such claims were caused by the negligence of GE or
Goodman.

A party may terminate the deed if there is an event of default by one of the other partys to the agreement and the
defaulting party fails to remedy the breach within 7 days after receiving notice requiring it to do so. A party is taken to have committed an event of default if they are insolvent or default under the deed and fail to remedy the breach within 30
days of receipt of written notice from another party requiring it to do so. We have agreed that if Goodman breaches any of its obligations under the deed, other than any breach caused or contributed to by delay or timeliness, our only claim will be
in damages against Goodman and we will not be entitled to terminate the deed, except that we may terminate the deed by notice in writing to the other parties and after consultation with the other parties if practical completion of the construction
of the new facility is not achieved on or before a specified sunset date. If the deed is validly terminated by GE arising from a breach by us, in addition to any other causes of action against us, we must pay damages as a result, including
compensation for lost rent and outgoings due to the lease not proceeding. If we validly terminate the deed, as a result of a breach by Goodman, then in addition to any other causes of action we may have, Goodman must pay damages as a result,
including compensation for consequential loss due to the lease not proceeding.

The lease which forms an annexure to the put and call
option deed contains customary representations, warranties, conditions and indemnifications of the parties. If the option under the deed is exercised, pursuant to the terms of the lease we would have a lease to the facility for a term of 15 years
with two options exercisable by us to extend the term of the lease by five years per option. We will be in default under the lease if any part of the rent or other amounts owing remain unpaid for 28 days after it is due, if we fail to perform or
observe any of our other obligations under the lease and have not rectified that failure within a reasonable time after receipt of written notice from GE, we become insolvent or we fail to comply with any of certain essential terms of the lease. If
an event of default occurs, GE may take possession of the facility and by notice terminate the lease.



|D. | Exchange Controls
|-- | -----------------

For a description of any
governmental laws, decrees, regulations or other legislation of Australia which may affect (1) the import or export of capital, including the availability of cash and cash equivalents for use by us, or (2) the remittance of dividends,
interest or other payments to nonresident holders of our securities, see Item 10. Additional Information  B. Constitution.



|E. | Taxation
|-- | --------

The following is a summary of certain
material Australian income tax and U.S. federal income tax considerations related to the ownership and disposition of our ordinary shares or ADSs that may be relevant to you if you are a U.S. Holder (as defined below). This summary is based on the
Australian and U.S. tax laws currently in effect. The term U.S. Holder means a beneficial owner of our ordinary shares or ADSs that is, for U.S. federal income tax purposes, a citizen or individual resident of the United States, a
domestic corporation, an estate whose income is subject to U.S. federal income tax regardless of its source, or a trust if a U.S. court can exercise primary supervision over the administration of the trust and one or more U.S. persons are authorized
to control all substantial



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decisions of the trust, or a trust that has a valid election in effect under applicable U.S. Treasury regulations to be treated as a U.S. person.

Prospective purchasers of our ordinary shares or ADSs should consult their own tax advisors regarding the application of the Australian and U.S.
federal income tax laws to their particular situations as well as any tax considerations under other tax laws (such as estate and give tax laws), or the laws of any province, state or local jurisdiction.

If an entity is treated as a partnership, the tax treatment of a partner will generally depend on the status of the partner and upon the activity of the
partnership. If you are a partner of a partnership that will hold our ordinary shares or ADSs, we suggest you consult your own tax advisor.

Australian
Taxation

The following summary of the Australian taxation implications is based on the provisions of the Income Tax Assessment Act
1936, the Income Tax Assessment Act 1997, the International Tax Agreements Act 1953, or IntTAA with the United States Convention as amended by the United States Protocol, or USDTA, public taxation rulings and available case law current as at the
date of this annual report, or collectively referred to in this section as Australian Taxation Laws. The Australian Taxation Laws and their interpretation are subject to change at any time.

General Principle of Taxation in Australia

This
summary discusses only two items of income that may arise from an investment in our ordinary shares or ADSs, namely:



| |  |  | gains realized from the sale of our ordinary shares or ADSs; and
| | - |  | ----------------------------------------------------------------



| |  |  | dividends that may be paid by us with respect to those shares and ADSs. Please note that we have not paid any dividends to date and do not expect to pay any in the
near to medium term.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Gains on Sale of Shares or ADSs

Under Australian law, tax is typically not payable on the gain made on the disposal of ordinary shares or ADSs by U.S. Holders.

However, a U.S Holder is liable to tax on the gain made on the disposal of ordinary shares or ADSs where the U.S. Holder is carrying on a business in
Australia through a permanent establishment or that are providing personal services in Australia through a fixed place of business. The gain made by the U.S Holder in these circumstances will be treated as either income or capital, depending on
whether or not the U.S Holder is carrying on a business of share trading in Australia. If the U.S Holder is carrying on a business of share trading in Australia, then the gain made on the sale of our ordinary shares or ADSs is regarded as ordinary
income and the U.S Holder will be taxed accordingly. If the U.S Holder is not carrying on a business of share trading in Australia, the gain made on the sale of our ordinary shares or ADSs is a capital gain. If the U.S Holder is an individual, a
complying superannuation entity, a trust or a life insurance company, the U.S Holder may be entitled to the CGT discount upon the disposal of our ordinary shares or ADSs held for at least 12 months. The CGT discount reduces the capital gain
otherwise liable to tax by 50% in the case of an individual or by 33% in the case of a complying superannuation entity or life insurance company. The capital gain (net of a CGT discount if applicable) must then be included in the assessable income
of the relevant U.S Holder and taxed accordingly.

Dividends

Dividends paid to U.S. Holders will be subject to the withholding tax provisions of the Australian Taxation Laws.



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The general withholding tax rate in Australia for dividends is 30% but under the USDTA this is reduced to
5% of the gross amount of the dividend if the person beneficially entitled to the dividend is a company which holds at least 10% of the voting power in the company or otherwise is reduced to 15%. If the U.S. Holder has held shares which hold a
voting power of at least 80% for at least a 12 month period then there may be no withholding tax if the holder is a certain type of person such as a listed company.

However certain dividends paid to non-residents are exempt from withholding tax. The exemption from withholding tax is explained below.

Australia has an imputation system which allows a company which distributes profits to its members to pass on to its members a credit for the tax already paid by the company to its members. This is known as a franking
credit. To the extent that the dividend is franked, the dividend is not subject to withholding tax. This means that a fully franked dividend is not subject to any withholding tax. To the extent that the dividend is not franked (ie unfranked
dividends), then that part of the dividend will be subject to withholding tax but at the reduced rate referred to above.

A dividend which
is unfranked is also exempt from withholding tax to the extent it is referable to certain categories of foreign income of the payer which are treated on a conduit basis in Australia.

If a US Holder holds shares in us through a permanent establishment in Australia, then dividends paid on those shares will not be subject to withholding
tax but will be assessed as taxable income in Australia and taxed at the marginal tax rates. Such a US Holder may be entitled to a tax offset for any franking credit attached to such dividends.

There are also additional exemptions depending on the nature of the shareholder which are designed to ensure that an entity that is otherwise exempt from
tax is not subject to withholding tax, e.g., charitable institutions.

U.S. Taxation

The following is a summary of certain material U.S. federal income tax considerations related to the ownership and disposition of our ordinary shares and
ADSs that may be relevant to you if you are a U.S. Holder. This summary is based on the Internal Revenue Code of 1986, as amended (the (Code), existing and proposed Treasury regulations promulgated under the Code and administrative and
judicial interpretations of the Code, all as of the date of this annual report and all of which are subject to change, possibly with retroactive effect.

This summary is also based in part upon the representations of the depositary and the assumption that each obligation in the deposit agreement and any related agreement will be performed in accordance with its terms.
In general, and taking into account such assumptions, a U.S. Holder of ADSs will be treated as an owner of the ordinary shares represented by those ADSs. Therefore, exchanges of ordinary shares for ADSs, and ADSs for ordinary shares, will not have
federal income tax consequences.

This summary deals only with ordinary shares and ADSs held as capital assets within the meaning of
Section 1221 of the Code. It does not discuss all of the tax considerations that may be relevant to U.S. Holders in light of their particular circumstances or to U.S. Holders subject to special rules, such as dealers in securities or
currencies, traders in securities that elect to mark-to-market their securities, expatriates, partnerships and other pass through entities, tax-exempt organizations, insurance companies, U.S. Holders subject to the alternative minimum tax, U.S.
Holders that actually or constructively own 10% or more of our ordinary shares, U.S. Holders holding our ordinary shares or ADSs as part of a hedging or constructive sale transaction, straddle, conversion transaction, or other integrated
transaction, or U.S. Holders whose functional currency is not the U.S. dollar.

Ownership of Ordinary Shares and ADSs

The gross amount of any distribution received by a U.S. Holder with respect to our ordinary shares or ADSs generally will be included in the U.S.
Holders gross income as a dividend to the extent attributable to our current and accumulated earnings and profits (as determined under U.S. federal income tax principles). To the extent a distribution received by a U.S. Holder is not a
dividend because it exceeds the U.S. Holders pro rata share of our current and accumulated earnings and profits, it will be treated first as a tax-free return of capital and reduce (but no below zero) the adjusted tax basis of the U.S.
Holders shares. To the extent the distribution exceeds the adjusted tax



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basis of the U.S. Holders shares, the remainder will be taxed as capital gain (the taxation of capital gain is discussed under the heading Sale
of Ordinary Shares and ADSs below).

For taxable years beginning after December 31, 2002 and before January 1, 2009,
dividends received by non-corporate U.S. holders from a qualified foreign corporation are taxed at the same preferential rates that apply to net long-term capital gains. A foreign corporation is a qualified foreign corporation if it is
eligible for the benefits of a comprehensive income tax treaty with the United States (the income tax treaty between Australia and the United States is such a treaty) or its shares or ADSs with respect to which such dividend is paid are readily
tradable on an established securities market in the United States (such as the Nasdaq National Market on which our ADSs will be traded). Notwithstanding satisfaction of one or both of these conditions, a foreign corporation is not a qualified
foreign corporation if it is a passive foreign investment company (PFIC) for the taxable year of the corporation in which the dividend is paid or the preceding taxable year. A foreign corporation will also not be a qualified foreign
corporation with respect to a particular holder (subject to certain limited exceptions) if it was a PFIC for any taxable year in that holders holding period. Dividends received from a foreign corporation that is not a qualified foreign
corporation will be taxed at ordinary income tax rates. As discussed in more detail below, under the section entitled TaxationPassive Foreign Investment Companies, there is a risk that we could be a PFIC in the future.

If a distribution is paid in Australian dollars, the U.S. dollar value of such distribution on the date of receipt is used to determine the amount of
the distribution received by a U.S. Holder (and the amount of Australian tax withheld, if any). A U.S. Holder who continues to hold such Australian dollars after the date on which they are received, may recognize gain or loss upon their disposition
due to exchange rate fluctuations. Generally such gains and losses will be ordinary income or loss from U.S. sources.

U.S. Holders may
deduct Australian tax withheld from distributions they receive from us for the purpose of computing their U.S. federal taxable income or alternatively elect to claim a foreign tax credit against their U.S. federal income tax liability for such
taxes. The foreign tax credit is subject to a number of limitations and the rules governing its determination are very complex. Prospective U.S. Holders should consult their own tax advisors to determine whether and to what extent they would be
entitled to claim a foreign tax credit.

Corporate U.S. Holders generally will not be allowed a dividends received deduction with respect
to dividends they receive from us.

Sale of Ordinary Shares and ADSs

Subject to the passive foreign investment company rules discussed below, a U.S. Holder that sells or otherwise disposes of ordinary shares or ADSs will recognize capital gain or loss equal to the difference between
the U.S. dollar value of the amount realized and its adjusted tax basis in those ordinary shares or ADSs. This gain or loss generally will be capital gain or loss from U.S. sources, and will be long-term capital gain or loss if the U.S. Holder held
its shares for more than 12 months. Generally, the net long-term capital gain of a non-corporate U.S. Holder recognized before January 1, 2009 is subject to tax at a top marginal rate of 15%. Capital gain that is not long-term capital gain is
taxed at ordinary income tax rates.

Passive Foreign Investment Companies

We will be a PFIC if in any taxable year either: (a) 75% or more of our gross income consists of passive income; or (b) 50% or more of the value
of our assets is attributable to assets that produce, or are held for the production of, passive income. Subject to certain limited exceptions, if we meet the gross income test or the asset test for a particular taxable year, ordinary shares or ADSs
held by a U.S. Holder in that year will be treated as shares of a PFIC (Pharmaxis PFIC Shares) for that year and all subsequent years in the U.S. Holders holding period, even if we fail to meet either test in a subsequent year.

Gain realized from the sale of Pharmaxis PFIC Shares will be subject to tax under the excess distribution regime, unless the U.S. Holder
makes one of the elections discussed below. Under the excess distribution regime, federal income tax on a U.S. Holders gain from the sale of Pharmaxis PFIC Shares would be calculated by allocating the gain ratably to each day the U.S. Holder
held its ordinary shares or ADSs . Gain allocated to years preceding the first year in which we were a PFIC in the U.S. Holders holding period, if any, and gain allocated to the year of disposition would be treated as gain arising in the year
of disposition and taxed as ordinary income. Gain allocated to all other years (the Pharmaxis PFIC Years) would be taxed at the highest tax rate in effect for each of



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those years. Interest for the late payment of tax would be calculated and added to the tax due for each of the Pharmaxis PFIC Years, as if the tax was due
and payable with the tax return filed for that year. A distribution that exceeds 125% of the average distributions received on Pharmaxis PFIC Shares by a U.S. Holder during the 3 preceding taxable years (or, if shorter, the portion of the U.S.
Holders holding period before the taxable year) would be taxed in a similar manner.

A U.S. Holder may avoid taxation under the
excess distribution regime by making a qualified electing fund (QEF) election. For each year that we would meet the PFIC gross income test or asset test, an electing U.S. Holder would be required to include in gross income, its pro rata
share of our net ordinary income and net capital gains, if any. The U.S. Holders adjusted tax basis in our shares would be increased by the amount of such income inclusions. An actual distribution to the U.S. Holder out of such income
inclusions would not be treated as a dividend and would decrease the U.S. Holders adjusted tax basis in our shares. Gain realized from the sale of our ordinary shares or ADSs covered by a QEF election would be taxed as a capital gain. A U.S.
Holder may make a QEF election, only if we agree in advance to provide the U.S. Holder the information necessary to allow the U.S. Holder to comply with the QEF rules. Due to the administrative burden associated with our providing this information
to each U.S. Holder, we will not agree to provide this information to U.S. Holders. Accordingly, a U.S. Holder will not be eligible to make a QEF election.

A U.S. Holder may also avoid taxation under the excess distribution regime by timely making a mark-to-market election. An electing U.S. Holder would include in gross income the increase in the value of its Pharmaxis
PFIC Shares during each of its taxable years and deduct from gross income the decrease in the value of its Pharmaxis PFIC Shares during each of its taxable years. Amounts included in gross income or deducted from gross income by an electing U.S.
Holder are treated as ordinary income and ordinary deductions from U.S. sources. Deductions for any year are limited to the amount by which the income inclusions of prior years exceed the income deductions of prior years. Gain from the sale of
Pharmaxis PFIC Shares covered by an election is treated as ordinary income from U.S. sources while a loss is treated as an ordinary deduction from U.S. sources only to the extent of prior income inclusions. Losses in excess of such prior income
inclusions are treated as capital losses from U.S. sources. A mark-to-market election is timely if it is made by the due date of the U.S. Holders tax return for the first taxable year in which the U.S. Holder held our ordinary shares or ADSs
that includes the close of our taxable year for which we met the PFIC gross income test or asset test. A mark-to-market election is made on IRS Form 8621.

As noted above (under the heading titled Ownership of Ordinary Shares and ADSs), a PFIC is not a qualified foreign corporation and hence dividends received from a PFIC are not eligible for taxation at
preferential net long-term capital gain tax rates. Similarly, ordinary income included in the gross income of a U.S. Holder as a result of the holder having made a QEF election or a mark-to-market election, and dividends received from corporations
subject to such election, are not eligible for taxation at preferential net long-term capital gain rates.

Based on an analysis of our
gross income and the value of our assets, we believe that we were not a PFIC for our taxable year ended June 30, 2007, but we were a PFIC for our taxable years ended June 30, 2006, June 30, 2005 and June 30, 2004. We do
anticipate being a PFIC in our current taxable year.

U.S. Information Reporting and Backup Withholding

United States information reporting and backup withholding requirements may apply with respect to distributions to U.S. Holders, or the payment of
proceeds from the sale of shares, unless the U.S. Holder: (a) is an exempt recipient (including a corporation); (b) complies with certain requirements, including applicable certification requirements; or (c) is described in certain
other categories of persons. The backup withholding tax rate is currently 28%. Any amounts withheld from a payment to a U.S. Holder under the backup withholding rules may be credited against any U.S. federal income tax liability of the U.S. Holder
and may entitle the U.S. Holder to a refund.



|F. | Dividends and Paying Agents
|-- | ---------------------------

Not applicable



|G. | Experts
|-- | -------

Not applicable.



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|H. | Documents on Display
|-- | --------------------

We will file annual reports
and other information with the Securities and Exchange Commission. We will file annual reports on Form 20-F and submit other information under cover of Form 6-K. As a foreign private issuer, we are exempt from the proxy
requirements of Section 14 of the Exchange Act and our officers, directors and principal shareholders will be exempt from the insider short-swing disclosure and profit recovery rules of Section 16 of the Exchange Act. Annual
reports and other information we file with the Commission may be inspected at the public reference facilities maintained by the Commission at Room 1024, Judiciary Plaza, 450 Fifth Street, N.W., Washington, D.C. 20549, and at its regional
offices located at 233 Broadway, New York, New York 10279 and 500 West Madison Street, Suite 1400, Chicago, Illinois 60661, and copies of all or any part thereof may be obtained from such offices upon payment of the prescribed fees. You
may call the Commission at 1-800-SEC-0330 for further information on the operation of the public reference rooms and you can request copies of the documents upon payment of a duplicating fee, by writing to the Commission. In addition, the
Commission maintains a web site that contains reports and other information regarding registrants (including us) that file electronically with the Commission which can be assessed at http://www.sec.gov.



|I. | Subsidiary Information
|-- | ----------------------

Not applicable.

ENFORCEABILITY OF CIVIL LIABILITIES

We are a
public company incorporated and domiciled under the laws of Australia. A majority of our directors and executive officers are residents of countries other than the United States. Furthermore, all or a substantial portion of their assets
and our assets are located outside the United States. As a result, it may not be possible for you to:



| |  |  | effect service of process within the United States upon any of our directors and executive officers or on us; or
| | - |  | ----------------------------------------------------------------------------------------------------------------



| |  |  | enforce in U.S. courts judgments obtained against any of our directors and executive officers or us in the U.S. courts in any action, including actions under the
civil liability provisions of U.S. securities laws;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | enforce in U.S. courts judgments obtained against any of our directors and senior management or us in courts of jurisdictions outside the United States in any
action, including actions under the civil liability provisions of U.S. securities laws; or
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | to bring an original action in an Australian court to enforce liabilities against any of our directors and executive officers or us based upon U.S. securities laws.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------

You may also have difficulties enforcing in courts outside the United States judgments obtained in the U.S. courts
against any of our directors and executive officers or us, including actions under the civil liability provisions of the U.S. securities laws.



|ITEM 11. | QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
|-------- | ----------------------------------------------------------

See Item 5. Operating and Financial Review and Prospects  B. Liquidity and Capital Resources  Quantitative and Qualitative Disclosures about Market Risk.



|ITEM 12. | DESCRIPTION OF SECURITIES OTHER THAN EQUITY SECURITIES
|-------- | ------------------------------------------------------

Not applicable.



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PART II



|ITEM 13. | DEFAULTS, DIVIDEND ARREARAGES AND DELINQUENCIES
|-------- | -----------------------------------------------

Not applicable.



|ITEM 14. | MATERIAL MODIFICATIONS TO THE RIGHTS OF SECURITY HOLDERS AND USE OF PROCEEDS
|-------- | ----------------------------------------------------------------------------



| | A. | Not applicable.
| | -- | ---------------



| | B. | Not applicable
| | -- | --------------



| | C. | Not applicable
| | -- | --------------



| | D. | Not applicable
| | -- | --------------



| | E. | Not applicable
| | -- | --------------



|ITEM 15T. | CONTROLS AND PROCEDURES
|--------- | -----------------------

A. Evaluation of Disclosure Controls
and Procedures

Under the supervision and with the participation of the Companys management, including the Chief Executive Officer
and Chief Financial Officer, the Company conducted an evaluation of the effectiveness of its disclosure controls and procedures (as such term is defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Control Act of 1934, as amended
(the Exchange Act)), as of June 30, 2007. Based on this evaluation, the Companys Chief Executive Officer and Chief Financial Officer concluded that the Companys disclosure controls and procedures were effective as of such
date. The Companys disclosure controls and procedures are designed to ensure that information required to be disclosed by us in the reports we file under the Exchange Act is recorded, processed, summarized and reported within the time periods
specified in the SECs rules and forms and that such information is accumulated and communicated to management, including the Chief Executive Officer and Chief Financial Officer, to allow timely decisions regarding required disclosure.

B. Managements annual report on internal control over financial reporting

Our management is responsible for establishing and maintaining adequate internal control over financial reporting, as such term is defined in Rules
13a-15(f) and 15d-15(f) under the Securities Exchange Act of 1934, as amended. The Companys internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and
the preparation of financial statements for external purposes in accordance with generally accepted accounting principles.

Because of its
inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of
changes in conditions, or that the degree of compliance with the policies may deteriorate.

Under the supervision and with the
participation of our management, including the Chief Executive Officer and Chief Financial Officer, we conducted an evaluation of the effectiveness of our internal control over financial reporting based on the framework in Internal Control 
Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission. Based on our evaluation, our management concluded that our internal control over financial reporting was effective as of June 30, 2007.

This annual report does not include an attestation report of the companys registered public accounting firm regarding internal
control over financial reporting. Managements report was not subject to attestation by the companys registered public accounting firm pursuant to temporary rules of the Securities and Exchange Commission that permit the company to
provide only managements report in this annual report.



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C. Changes in Internal Controls Over Financial Reporting

There were no changes in our internal control over financial reporting (as defined in Rule 13a-15(f) of the Exchange Act) that occurred during the year
ended June 30, 2007 that have materially affected, or are reasonably likely to materially affect, our internal controls over financial reporting.



|ITEM 16A. | AUDIT COMMITTEE FINANCIAL EXPERT
|--------- | --------------------------------

Our board of
directors adopted its audit committee charter on December 4, 2003 and reviews the charter annually. The last amendments to the charter were made on August 9, 2007. Our board has determined that we do not have a financial expert serving on
our audit committee as defined by Item 401(h) of Regulation S-K of the Exchange Act.

We believe that the combined knowledge, skills
and experience of the members of our Audit Committee enables them, as a group, to act effectively in the fulfillment of their tasks and responsibilities, including those under the Sarbanes-Oxley Act of 2002, without appointing a member who would
qualify as an audit committee financial expert.



|ITEM 16B. | CODE OF ETHICS
|--------- | --------------

We have adopted a Code of Conduct
that applies to the Chief Executive Officer and all senior financial officers, or persons performing similar functions, of the Company. A copy of the Companys Code of Conduct is attached as an exhibit to this annual report on Form 20-F. The
Code of Conduct is also posted on the Companys website at www.pharmaxis.com.au. Any future changes to the Code of Conduct will be posted on the Companys website within five business days of the change being effective.



|ITEM 16C. | PRINCIPAL ACCOUNTANT FEES AND SERVICES
|--------- | --------------------------------------

The
following table represents aggregate fees billed to the Company for fiscal years ended June 30, 2007 and June 30, 2006 by PricewaterhouseCoopers , the Companys principal accounting firm.



|                   |  |                      |     |      |   |    
|------------------ |  | -------------------- | --- | ---- | - | ---
|                   |  | Years ended June 30,
|                   |  | 2005                 |     | 2006
|                   |  | (in thousands)      
|Audit fees         |  | $                    | 678 |      | $ | 435
|Audit-related fees |  |                      |    |      |   |   
|Tax                |  |                      | 26  |      |   | 22 
|Other              |  |                      |    |      |   |   
|                   |  |                      |     |      |   |    
|                   |  | $                    | 704 |      | $ | 457
|                   |  |                      |     |      |   |    

Audit fees include fees for audit or review services in accordance with generally accepted
auditing standards and fees for services that generally only the auditor can reasonably provide.

The Audit Committee of our Board of
Directors chooses and engages our independent auditors to audit our financial statements. In 2005, our Board of Directors also adopted a policy requiring management to obtain the audit committees approval before engaging our independent
auditors to provide any other audit or permitted non-audit services to us. This policy, which is designed to assure that such engagements do not impair the independence of our auditors, requires the audit committee to pre-approve audit and non-audit
services that may be performed by our auditors.



|ITEM 16D. | EXEMPTIONS FROM THE LISTING STANDARDS FOR AUDIT COMMITTEES
|--------- | ----------------------------------------------------------



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Not applicable



|ITEM 16E. | PURCHASES OF EQUITY SECURITIES BY THE ISSUER AND AFFILIATED PURCHASERS
|--------- | ----------------------------------------------------------------------

Not applicable.



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PART III



|ITEM 17. | FINANCIAL STATEMENTS
|-------- | --------------------

Not applicable.



|ITEM 18. | FINANCIAL STATEMENTS
|-------- | --------------------

The financial statements are
included as the F pages attached to this report



|ITEM 19. | EXHIBITS
|-------- | --------

The following exhibits are filed as part
of this report



|            |  |                                                                                                                                                                                                                  
|----------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|EXHIBIT NO. |  | DESCRIPTION                                                                                                                                                                                                      
|            | 
|1.1         |  | Constitution as amended by shareholders on November 5, 2007                                                                                                                                                      
|            | 
|2.1         |  | Form of American Depositary Receipt (included in Exhibit 2.2) *                                                                                                                                                  
|            | 
|2.2         |  | Form of Depositary Agreement (Incorporated by reference to the Registration Statement on Form F-6 (File No. 333-120026) filed by the Company with the Commission on
October 28, 2004)                            
|            | 
|4.1         |  | Form of Deed of Access to Documents and Indemnity entered into with Company Directors and Company Secretary*                                                                                                     
|            | 
|4.2         |  | Form of Employment Agreement entered into with Company Officers*                                                                                                                                                 
|            | 
|4.3         |  | Lease dated August 22, 2006 between Trust Company of Australia Ltd and the Company**                                                                                                                             
|            | 
|4.4         |  | Agreement dated October 14, 1999 between ANU Enterprises Pty Ltd (formerly Anutech Pty Ltd) and the Company (formerly Praxis Pharmaceuticals Australia Pty Ltd), as amended*                                     
|            | 
|4.5         |  | Patent License Agreement dated October 10, 2001 between the Company (formerly Praxis Pharmaceuticals Australia Pty Ltd) and Sydney South West Area Health Service (formerly Central Sydney
Area Health Service) *
|            | 
|4.6         |  | Service Agreement dated December 9, 2002 between ANU Enterprises Pty Ltd (formerly Anutech Pty Ltd) and the Company, as amended*                                                                                 
|            | 
|4.7         |  | R&D Start Grant Program Grant Agreement dated June 17, 2003 between the Commonwealth of Australia (acting through the Industry Research and Development Board) and the Company*                                  
|            | 
|4.8         |  | Pharmaceuticals Partnerships Program P3Funding Agreement dated August 12, 2004 between the
Commonwealth of Australia (represented by the Department of Industry, Tourism and Resources) and the Company*         
|            | 
|4.9         |  | Put and Call Option to Lease between GE Real Estate Investments Australia Pty Limited, Goodman Property Services (Aust) Pty Limited and the Company                                                              
|            | 
|11.         |  | Code of Conduct                                                                                                                                                                                                  
|            | 
|12.         |  | Certification required by Rule 13a-14(a)                                                                                                                                                                         
|            | 
|13.         |  | Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                                                                                           
|            | 
|15.         |  | Consent of PricewaterhouseCoopers                                                                                                                                                                                

---

|* | Incorporated by reference to our Registration Statement on Form F-1 (File No. 000-51505)
|- | ----------------------------------------------------------------------------------------

|** | Incorporated by reference to our Annual Report on Form 20-F for the year ended June 30, 2006 (File No. 000-51505)
|-- | -----------------------------------------------------------------------------------------------------------------



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##### Table of Contents

SIGNATURES

The registrant hereby certifies that it meets all of the requirements for filing on Form 20-F and that it has duly caused and authorized the undersigned to sign this registration statement on its behalf.



PHARMAXIS LTDBy:

/s/ David M. McGarveyName: David M. McGarveyTitle:   Chief Financial Officer


Date: November 21, 2007



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##### Table of Contents

Index to Financial Statements



|                                                                                                                                            |  |     
|------------------------------------------------------------------------------------------------------------------------------------------- |  | ----
|Report of PricewaterhouseCoopers, Independent Registered Public Accounting Firm                                                             |  | F-2 
|Balance Sheets as of June 30, 2006 and 2007                                                                                                 |  | F-3 
|Statements of Operations for the years ended June 30, 2005, 2006 and 2007 and for the period from inception (May 29, 1998) to June 30, 2007 |  | F-4 
|Statements of Changes in Shareholders (Deficit) Equity for the period from inception (May 29, 1998) to June 30, 2007                       |  | F-5 
|Statements of Cash Flows for the years ended June 30, 2005, 2006 and 2007 and for the period from inception (May 29, 1998) to June 30, 2007 |  | F-7 
|Notes to Financial Statements                                                                                                               |  | F-8 
|Schedule II  Valuation and Qualifying Accounts                                                                                             |  | F-22



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##### Table of Contents

LOGO

Report of Independent Registered Public Accounting Firm

To the Board of Directors and Shareholders of Pharmaxis Ltd:

In our opinion, the accompanying consolidated balance sheets and the related consolidated statements of operations, shareholders equity (deficit) and
cash flows present fairly, in all material respects, the financial position of Pharmaxis Ltd and its subsidiaries (a development stage enterprise) at June 30, 2007 and 2006, and the results of their operations and their cash flows for each of
the three years in the period ended June 30, 2007 and, cumulatively, for the period from May 29, 1998 (date of inception) to June 30, 2007 in conformity with accounting principles generally accepted in the United States of America.
These financial statements are the responsibility of the Companys management. Our responsibility is to express an opinion on these financial statements and the financial schedule based on our audits. We conducted our audits of these statements
in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and the financial
statement schedule are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made
by management, and evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

PricewaterhouseCoopers

WHB Seaton

Sydney, Australia

21 November 2007



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##### Table of Contents

Pharmaxis Ltd

(A Development Stage Enterprise)

Balance Sheets

(Australian dollars)



|                                                                                                                   |  |                                   |         |   |      |   |         |  
|------------------------------------------------------------------------------------------------------------------ |  | --------------------------------- | ------- | - | ---- | - | ------- | -
|                                                                                                                   |  | As of June 30,                    |        
|                                                                                                                   |  | 2006                              |         |   | 2007 |  
|                                                                                                                   |  | (in thousands, except share data) |        
|ASSETS                                                                                                             |  |                                   |         |   |      |   |         |  
|Current assets:                                                                                                    |  |                                   |         |   |      |   |         |  
|Cash and cash equivalents                                                                                          |  | $                                 | 97,840  |   |      | $ | 76,182  |  
|Grant receivable                                                                                                   |  |                                   | 400     |   |      |   | 407     |  
|Accounts receivable                                                                                                |  |                                   | 7       |   |      |   | 34      |  
|Inventory                                                                                                          |  |                                   | 100     |   |      |   | 79      |  
|Other current assets                                                                                               |  |                                   | 964     |   |      |   | 585     |  
|                                                                                                                   |  |                                   |         |   |      |   |         |  
|Total current assets                                                                                               |  |                                   | 99,311  |   |      |   | 77,287  |  
|Property, plant and equipment, net                                                                                 |  |                                   | 3,289   |   |      |   | 3,752   |  
|Intangible assets, net                                                                                             |  |                                   | 1,057   |   |      |   | 1,002   |  
|Other long-term assets                                                                                             |  |                                   | 556     |   |      |   | 601     |  
|                                                                                                                   |  |                                   |         |   |      |   |         |  
|Total assets                                                                                                       |  | $                                 | 104,213 |   |      | $ | 82,642  |  
|                                                                                                                   |  |                                   |         |   |      |   |         |  
|LIABILITIES AND SHAREHOLDERS EQUITY                                                                               |  |                                   |         |   |      |   |         |  
|Current liabilities:                                                                                               |  |                                   |         |   |      |   |         |  
|Accounts payable                                                                                                   |  | $                                 | 813     |   |      | $ | 2,654   |  
|Accrued compensation                                                                                               |  |                                   | 781     |   |      |   | 799     |  
|Accrued clinical development liabilities                                                                           |  |                                   | 3,013   |   |      |   | 1,636   |  
|Income tax payable                                                                                                 |  |                                   | 5       |   |      |   | 24      |  
|Other accrued liabilities                                                                                          |  |                                   | 650     |   |      |   | 855     |  
|                                                                                                                   |  |                                   |         |   |      |   |         |  
|Total current liabilities                                                                                          |  |                                   | 5,262   |   |      |   | 5,968   |  
|Non-current liabilities:                                                                                           |  |                                   |         |   |      |   |         |  
|Accrued compensation                                                                                               |  |                                   | 63      |   |      |   | 115     |  
|                                                                                                                   |  |                                   |         |   |      |   |         |  
|Total non-current liabilities                                                                                      |  |                                   | 63      |   |      |   | 115     |  
|Commitments and Contingencies (Refer to note 13)                                                                   |  |                                   |         |   |      |   |         |  
|Shareholders equity:                                                                                              |  |                                   |         |   |      |   |         |  
|Ordinary shares, $Nil par value; 176,903,592 and 177,949,217 shares issued at June 30, 2006 and 2007, respectively |  |                                   | 137,492 |   |      |   | 139,343 |  
|Foreign currency translation reserve                                                                               |  |                                   | 1       |   |      |   |        |  
|Deficit accumulated during the development stage                                                                   |  |                                   | (38,605 | ) |      |   | (62,784 | )
|                                                                                                                   |  |                                   |         |   |      |   |         |  
|Total shareholders equity                                                                                         |  |                                   | 98,888  |   |      |   | 76,559  |  
|                                                                                                                   |  |                                   |         |   |      |   |         |  
|Total liabilities and shareholders equity                                                                         |  | $                                 | 104,213 |   |      | $ | 82,642  |  
|                                                                                                                   |  |                                   |         |   |      |   |         |  

See accompanying notes to the financial statements.



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##### Table of Contents

Pharmaxis Ltd

(A Development Stage Enterprise)

Statements of Operations

(Australian dollars)



|                                                            |  |                                       |         |   |                                                   |   |         |      |  |   |         |   |  |   |         |  
|----------------------------------------------------------- |  | ------------------------------------- | ------- | - | ------------------------------------------------- | - | ------- | ---- |  | - | ------- | - |  | - | ------- | -
|                                                            |  | Years ended June 30,                  |         |   | Period frominception(May 29, 1998)to June 30,2007 |  
|                                                            |  | 2005                                  |         |   | 2006                                              |   |         | 2007 |  |  
|                                                            |  | (in thousands, except per share data) |        
|Revenue                                                     |  | $                                     |        |   |                                                   | $ | 8       |      |  | $ | 205     |   |  | $ | 213     |  
|Cost of goods sold                                          |  |                                       |        |   |                                                   |   | 2       |      |  |   | 49      |   |  |   | 51      |  
|                                                            |  |                                       |         |   |                                                   |   |         |      |  |   |         |   |  |   |         |  
|Gross profit                                                |  |                                       |        |   |                                                   |   | 6       |      |  |   | 156     |   |  |   | 162     |  
|Operating expenses:                                         |  |                                       |         |   |                                                   |   |         |      |  |   |         |   |  |   |         |  
|Research and development                                    |  |                                       | 7,885   |   |                                                   |   | 14,982  |      |  |   | 21,177  |   |  |   | 50,824  |  
|General and administrative                                  |  |                                       | 3,105   |   |                                                   |   | 4,005   |      |  |   | 3,973   |   |  |   | 14,528  |  
|Commercial                                                  |  |                                       | 807     |   |                                                   |   | 1,764   |      |  |   | 2,814   |   |  |   | 5,385   |  
|Amortization of intangible assets                           |  |                                       | 90      |   |                                                   |   | 136     |      |  |   | 95      |   |  |   | 716     |  
|Fair value of stock options issued to employees related to: |  |                                       |         |   |                                                   |   |         |      |  |   |         |   |  |   |         |  
|Research and development                                    |  |                                       | 115     |   |                                                   |   | 613     |      |  |   | 569     |   |  |   | 1,935   |  
|Commercial                                                  |  |                                       | 116     |   |                                                   |   | 175     |      |  |   | 276     |   |  |   | 567     |  
|General and administrative                                  |  |                                       | 29      |   |                                                   |   | 336     |      |  |   | 643     |   |  |   | 1,505   |  
|                                                            |  |                                       |         |   |                                                   |   |         |      |  |   |         |   |  |   |         |  
|Total operating expenses                                    |  |                                       | 12,147  |   |                                                   |   | 22,011  |      |  |   | 29,547  |   |  |   | 75,460  |  
|                                                            |  |                                       |         |   |                                                   |   |         |      |  |   |         |   |  |   |         |  
|Loss from operations                                        |  |                                       | (12,147 | ) |                                                   |   | (22,005 | )    |  |   | (29,391 | ) |  |   | (75,298 | )
|Interest and other income                                   |  |                                       | 1,702   |   |                                                   |   | 4,282   |      |  |   | 5,278   |   |  |   | 12,816  |  
|Foreign currency gain (loss)                                |  |                                       |        |   |                                                   |   | (5      | )    |  |   | (47     | ) |  |   | (52     | )
|Amortization of preference share issue expenses             |  |                                       |        |   |                                                   |   |        |      |  |   |        |   |  |   | (226    | )
|                                                            |  |                                       |         |   |                                                   |   |         |      |  |   |         |   |  |   |         |  
|Net loss before income tax                                  |  | $                                     | (10,445 | ) |                                                   | $ | (17,728 | )    |  | $ | (24,160 | ) |  | $ | (62,760 | )
|Income tax expense                                          |  |                                       |        |   |                                                   |   | (5      | )    |  |   | (19     | ) |  |   | (24     | )
|                                                            |  |                                       |         |   |                                                   |   |         |      |  |   |         |   |  |   |         |  
|Net loss                                                    |  | $                                     | (10,445 | ) |                                                   | $ | (17,733 | )    |  | $ | (24,179 | ) |  | $ | (62,784 | )
|                                                            |  |                                       |         |   |                                                   |   |         |      |  |   |         |   |  |   |         |  
|Basic and diluted net loss per share                        |  | $                                     | (0.08   | ) |                                                   | $ | (0.11   | )    |  | $ | (0.14   | ) |  |   |         |  

See accompanying notes to the financial statements.



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##### Table of Contents

Pharmaxis Ltd

(A Development Stage Enterprise)

Statements of Changes in Shareholders (Deficit) Equity

(Australian
dollars)



|                                                                                                                                                                                    |  |                                   |   |                    |        |        |                                   |   |                                    |   |  |   |  |   |         |  
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | --------------------------------- | - | ------------------ | ------ | ------ | --------------------------------- | - | ---------------------------------- | - |  | - |  | - | ------- | -
|                                                                                                                                                                                    |  | Ordinary shares                   |   | AccumulatedDeficit |        |        | ForeignCurrencyTranslationReserve |   | Total Shareholders(Deficit)Equity |  
|                                                                                                                                                                                    |  | Shares                            |   |                    | Amount |        |                                   |  
|                                                                                                                                                                                    |  | (in thousands, except share data) |   |                    |       
|Balance at inception (May 29, 1998)                                                                                                                                                 |  |                                  |   |                    |        |       |                                   |   |                                   |   |  |  |  |   |        |  
|Issuance of ordinary shares at $0.125 per share for cash on incorporation of the Company in May 1998                                                                                |  | 808                               |   |                    |        |       |                                   |   |                                   |   |  |  |  |   |        |  
|Issuance of ordinary shares at $0.125 per share as consideration for patent license                                                                                                 |  | 11,200,000                        |   |                    |        | 1,400  |                                   |   |                                   |   |  |  |  |   | 1,400   |  
|Fair value of stock options issued to directors and employees in year ended June 30, 2000                                                                                           |  |                                  |   |                    |        | 74     |                                   |   |                                   |   |  |  |  |   | 74      |  
|Fair value of stock options issued to directors and employees in year ended June 30, 2001                                                                                           |  |                                  |   |                    |        | 77     |                                   |   |                                   |   |  |  |  |   | 77      |  
|Fair value of stock options issued to directors and employees in year ended June 30, 2002                                                                                           |  |                                  |   |                    |        | 70     |                                   |   |                                   |   |  |  |  |   | 70      |  
|Net loss for period from inception to June 30, 2002                                                                                                                                 |  |                                  |   |                    |        |       |                                   |   | (1,667                             | ) |  |  |  |   | (1,667  | )
|Cancellation of common stock                                                                                                                                                        |  | (808                              | ) |                    |        |       |                                   |   |                                   |   |  |  |  |   |        |  
|Fair value of stock options issued to directors and employees                                                                                                                       |  |                                  |   |                    |        | 383    |                                   |   |                                   |   |  |  |  |   | 383     |  
|Conversion of A and B class convertible redeemable preference shares to ordinary shares                                                                                         |  | 46,816,000                        |   |                    |        | 11,631 |                                   |   |                                   |   |  |  |  |   | 11,631  |  
|Issuance of ordinary shares at $0.50 per share for cash in initial public offering of Company in Australia in November 2003, net of issuance
costs                                  |  | 50,000,000                        |   |                    |        | 22,891 |                                   |   |                                   |   |  |  |  |   | 22,891  |  
|Fair value of stock options issued to directors and employees in the year ended 30 June 2004                                                                                        |  |                                  |   |                    |        | 532    |                                   |   |                                   |   |  |  |  |   | 532     |  
|Net loss                                                                                                                                                                            |  |                                  |   |                    |        |       |                                   |   | (8,760                             | ) |  |  |  |   | (8,760  | )
|                                                                                                                                                                                    |  |                                   |   |                    |        |        |                                   |   |                                    |   |  |   |  |   |         |  
|Balance at June 30, 2004                                                                                                                                                            |  | 108,016,000                       |   |                    |        | 37,058 |                                   |   | (10,427                            | ) |  |  |  |   | 26,631  |  
|Issuance of ordinary shares at $0.75 per share for cash in private placement to Australian institutional and sophisticated investors closed in
December 2004, net of issuance costs |  | 22,000,000                        |   |                    |        | 15,702 |                                   |   |                                   |   |  |  |  |   | 15,702  |  
|Share purchase plan closed in December 2004 at $0.75 per share, net of issuance costs                                                                                               |  | 4,362,092                         |   |                    |        | 3,256  |                                   |   |                                   |   |  |  |  |   | 3,256   |  
|Issuance of ordinary shares upon exercise of employee options                                                                                                                       |  | 392,000                           |   |                    |        | 63     |                                   |   |                                   |   |  |  |  |   | 63      |  
|Fair value of stock options issued to directors and employees                                                                                                                       |  |                                  |   |                    |        | 260    |                                   |   |                                   |   |  |  |  |   | 260     |  
|Net loss                                                                                                                                                                            |  |                                  |   |                    |        |       |                                   |   | (10,445                            | ) |  |  |  |   | (10,445 | )
|                                                                                                                                                                                    |  |                                   |   |                    |        |        |                                   |   |                                    |   |  |   |  |   |         |  
|Balance at June 30, 2005                                                                                                                                                            |  | 134,770,092                       |   |                    | $      | 56,339 |                                   | $ | (20,872                            | ) |  |  |  | $ | 35,467  |  



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##### Table of Contents

|                                                                                                                                                                                    |  |                                   |  |                    |         |  |                                   |         |   |                                    |   |    |   |  |   |         |  
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | --------------------------------- |  | ------------------ | ------- |  | --------------------------------- | ------- | - | ---------------------------------- | - | -- | - |  | - | ------- | -
|                                                                                                                                                                                    |  | Ordinary shares                   |  | AccumulatedDeficit |         |  | ForeignCurrencyTranslationReserve |         |   | Total Shareholders(Deficit)Equity |  
|                                                                                                                                                                                    |  | Shares                            |  | Amount             |         |  |                                  
|                                                                                                                                                                                    |  | (in thousands, except share data) |  |                    |         | 
|Issuance of ordinary shares at $2.1899 per share cash in public offering to U.S. public investors closed in November 2005, net of issuance
costs                                    |  | 19,500,000                        |  |                    | 38,154  |  |                                   |        |   |                                    |   |   |   |  |   | 38,154  |  
|Issuance of ordinary shares at $2.20 per share for cash in private placement to Australian institutional and sophisticated investors closed in
November 2005, net of issuance costs |  | 19,900,000                        |  |                    | 41,278  |  |                                   |        |   |                                    |   |   |   |  |   | 41,278  |  
|Issuance of ordinary shares upon exercise of employee options                                                                                                                       |  | 2,733,500                         |  |                    | 598     |  |                                   |        |   |                                    |   |   |   |  |   | 598     |  
|Fair value of stock options issued to directors and employees                                                                                                                       |  |                                  |  |                    | 1,123   |  |                                   |        |   |                                    |   |   |   |  |   | 1,123   |  
|Net loss                                                                                                                                                                            |  |                                  |  |                    |        |  |                                   | (17,733 | ) |                                    |   |   |   |  |   | (17,733 | )
|Gain on translation of foreign currency net assets                                                                                                                                  |  |                                  |  |                    |        |  |                                   |        |   |                                    |   | 1  |   |  |   | 1       |  
|                                                                                                                                                                                    |  |                                   |  |                    |         |  |                                   |         |   |                                    |   |    |   |  |   |         |  
|Balance at June 30, 2006                                                                                                                                                            |  | 176,903,592                       |  | $                  | 137,492 |  | $                                 | (38,605 | ) |                                    | $ | 1  |   |  | $ | 98,888  |  
|Issuance of ordinary shares upon exercise of employee options                                                                                                                       |  | 1,045,625                         |  |                    | 363     |  |                                   |        |   |                                    |   |   |   |  |   | 363     |  
|Fair value of stock options issued to directors and employees                                                                                                                       |  |                                  |  |                    | 1,488   |  |                                   |        |   |                                    |   |   |   |  |   | 1,488   |  
|Net loss                                                                                                                                                                            |  |                                  |  |                    |        |  |                                   | (24,179 | ) |                                    |   |   |   |  |   | (24,179 | )
|Loss on translation of foreign currency net assets                                                                                                                                  |  |                                  |  |                    |        |  |                                   |        |   |                                    |   | (1 | ) |  |   | (1      | )
|                                                                                                                                                                                    |  |                                   |  |                    |         |  |                                   |         |   |                                    |   |    |   |  |   |         |  
|Balance at June 30, 2007                                                                                                                                                            |  | 177,949,217                       |  | $                  | 139,343 |  | $                                 | (62,784 | ) |                                    | $ |   |   |  | $ | 76,559  |  
|                                                                                                                                                                                    |  |                                   |  |                    |         |  |                                   |         |   |                                    |   |    |   |  |   |         |  

See accompanying notes to the financial statements.



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##### Table of Contents

Pharmaxis Ltd

(A Development Stage Enterprise)

Statements of Cash Flows

(Australian dollars)



|                                                                                                        |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|------------------------------------------------------------------------------------------------------- |  | -------------------- | ------- | - | ------------------------------------ | - | ------- | ---- |  | - | ------- | - |  | - | ------- | -
|                                                                                                        |  | Years ended June 30, |         |   | Period frominceptionto June 30, 2007 |  
|                                                                                                        |  | 2005                 |         |   | 2006                                 |   |         | 2007 |  |  
|                                                                                                        |  | (in thousands)       |        
|Cash flows from operating activities:                                                                   |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Net loss                                                                                                |  | $                    | (10,445 | ) |                                      | $ | (17,733 | )    |  | $ | (24,179 | ) |  | $ | (62,784 | )
|Adjustments to reconcile net loss to net cash used in operating activities:                             |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Depreciation and impairment of plant & equipment                                                        |  |                      | 489     |   |                                      |   | 763     |      |  |   | 797     |   |  |   | 2,624   |  
|Amortization and impairment of intangible assets                                                        |  |                      | 90      |   |                                      |   | 137     |      |  |   | 95      |   |  |   | 717     |  
|Amortization of preference share issue expenses                                                         |  |                      |        |   |                                      |   |        |      |  |   |        |   |  |   | 226     |  
|Loss on disposal of property, plant and equipment                                                       |  |                      |        |   |                                      |   |        |      |  |   | 24      |   |  |   | 24      |  
|Write-off of non-current assets                                                                         |  |                      |        |   |                                      |   | 40      |      |  |   |        |   |  |   | 40      |  
|Fair value of stock options issued for service                                                          |  |                      | 260     |   |                                      |   | 1,124   |      |  |   | 1,488   |   |  |   | 4,008   |  
|Change in assets and liabilities:                                                                       |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Accounts receivable                                                                                     |  |                      |        |   |                                      |   | (7      | )    |  |   | (27     | ) |  |   | (34     | )
|Inventory                                                                                               |  |                      |        |   |                                      |   | (100    | )    |  |   | 21      |   |  |   | (79     | )
|Prepaid expenses and other current assets                                                               |  |                      | (454    | ) |                                      |   | (246    | )    |  |   | 379     |   |  |   | (585    | )
|Grant receivable                                                                                        |  |                      | (106    | ) |                                      |   | (294    | )    |  |   | (7      | ) |  |   | (407    | )
|Other long-term assets                                                                                  |  |                      | (2      | ) |                                      |   | (294    | )    |  |   | (45     | ) |  |   | (601    | )
|Accounts payable                                                                                        |  |                      | 512     |   |                                      |   | 56      |      |  |   | 1,841   |   |  |   | 2,654   |  
|Accrued compensation                                                                                    |  |                      | 190     |   |                                      |   | 67      |      |  |   | 70      |   |  |   | 914     |  
|Accrued clinical development liabilities                                                                |  |                      | (260    | ) |                                      |   | 2,468   |      |  |   | (1,377  | ) |  |   | 1,637   |  
|Income tax payable                                                                                      |  |                      |        |   |                                      |   | 5       |      |  |   | 19      |   |  |   | 24      |  
|Other accrued liabilities                                                                               |  |                      | 446     |   |                                      |   | 361     |      |  |   | 205     |   |  |   | 855     |  
|                                                                                                        |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Net cash used in operating activities                                                                   |  |                      | (9,280  | ) |                                      |   | (13,653 | )    |  |   | (20,696 | ) |  |   | (50,767 | )
|                                                                                                        |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Cash flows from investing activities:                                                                   |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Purchases of property, plant and equipment                                                              |  |                      | (1,541  | ) |                                      |   | (1,716  | )    |  |   | (1,335  | ) |  |   | (6,491  | )
|Proceeds on disposal of property, plant and equipment                                                   |  |                      |        |   |                                      |   |        |      |  |   | 52      |   |  |   | 52      |  
|Payment for patent and trademark applications                                                           |  |                      | (33     | ) |                                      |   | (88     | )    |  |   | (40     | ) |  |   | (319    | )
|                                                                                                        |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Net cash used in investing activities                                                                   |  |                      | (1,574  | ) |                                      |   | (1,804  | )    |  |   | (1,323  | ) |  |   | (6,758  | )
|                                                                                                        |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Cash flows from financing activities:                                                                   |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Proceeds from issuance of ordinary shares, net of issuance costs                                        |  |                      | 18,958  |   |                                      |   | 79,432  |      |  |   |        |   |  |   | 121,281 |  
|Proceeds from issuance of ordinary shares from the exercise of employee options                         |  |                      | 63      |   |                                      |   | 597     |      |  |   | 363     |   |  |   | 1,023   |  
|Proceeds from issuance of A class convertible redeemable preference shares, net of issuance costs     |  |                      |        |   |                                      |   |        |      |  |   |        |   |  |   | 2,000   |  
|Proceeds from issuance of B class convertible redeemable preference shares, net of issuance costs     |  |                      |        |   |                                      |   |        |      |  |   |        |   |  |   | 9,405   |  
|                                                                                                        |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Net cash provided by financing activities                                                               |  |                      | 19,021  |   |                                      |   | 80,029  |      |  |   | 363     |   |  |   | 133,709 |  
|                                                                                                        |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Net increase (decrease) in cash and cash equivalents                                                    |  |                      | 8,167   |   |                                      |   | 64,572  |      |  |   | (21,656 | ) |  |   | 76,184  |  
|Cash and cash equivalents at beginning of period                                                        |  |                      | 25,101  |   |                                      |   | 33,268  |      |  |   | 97,840  |   |  |   |        |  
|Effects of exchange rate changes on cash and cash equivalents                                           |  |                      |        |   |                                      |   |        |      |  |   | (2      | ) |  |   | (2      | )
|                                                                                                        |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Cash and cash equivalents at end of period                                                              |  | $                    | 33,268  |   |                                      | $ | 97,840  |      |  | $ | 76,182  |   |  | $ | 76,182  |  
|                                                                                                        |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Supplemental non-cash activities:                                                                       |  |                      |         |   |                                      |   |         |      |  |   |         |   |  |   |         |  
|Issuance of ordinary shares on conversion of A and B class convertible redeemable preference shares |  | $                    |        |   |                                      | $ |        |      |  | $ |        |   |  | $ | 11,631  |  

See accompanying notes to the financial statements.



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Pharmaxis Ltd

(A Development Stage Enterprise)

Notes to Financial Statements

(for the years ended June 30, 2004, 2005,
2006 and 2007 and for the period from inception

(May 29, 1998) to June 30, 2007)

(in A$ thousands, except share and per share amounts)

1. Organization of the Company

Pharmaxis Ltd (the Company) was incorporated on May 29, 1998 in the Australian Capital
Territory, Australia. On June 6, 2002 the Company changed its name from Praxis Pharmaceuticals Australia Pty Ltd to Pharmaxis Pty Ltd. On September 5, 2003 the Company changed its name from Pharmaxis Pty Ltd to Pharmaxis Ltd. The Company
was listed on the Australian Securities Exchange on November 10, 2003 following its initial public offering and on the NASDAQ Global Market on August 29, 2005.

The Companys primary activities since incorporation have been the purchase of a license for our autoimmune technology from the Australian National University; conducting research in the area of autoimmune
diseases; the filing of five new patent families; commencing preclinical development of one autoimmune candidate (PXS25); obtaining a license for our respiratory technology from the Sydney South West Area Health Service; establishing our own
manufacturing facility for the production of Aridol and Bronchitol to standards of Good Manufacturing Practice; obtaining a license to manufacture to GMP from the Australian Therapeutics Goods Administration; commencing and successfully completing
an Australian Phase III clinical trial and a U.S. Phase III clinical trial of our lung capacity test Aridol for the diagnosis of the existence and severity of asthma; obtaining regulatory marketing approval in Australian and Europe, commencing and
successfully completing a 60 subject, four center Phase II clinical trial of Bronchitol for the disease bronchiectasis; commencing and successfully completing a 59 subject, eight center Phase II clinical trial of Bronchitol for the disease cystic
fibrosis; completing a 362 subject, 22 center Phase III clinical trial of Bronchitol in the disease bronchiectasis ; establishing a management team with relevant experience in sales and marketing, manufacturing, clinical trial management, regulatory
affairs and finance; initial Aridol sales in Australia and listing the Company on the Australian Securities Exchange and the NASDAQ Global Market.

2.
Basis of Presentation

Pharmaxis Ltd is an Australian company and its operations are located there. Accordingly, its books of account are maintained in
Australian dollars and its annual and interim financial statements are prepared in accordance with Australian International Financial Reporting Standards (AIFRS). These financial statements are presented in accordance with the accounting
principles generally accepted in the United States of America (U.S. GAAP). All amounts are expressed in Australian dollars and are rounded to the nearest thousand, except share and per share data.

The Companys financial statements have been prepared assuming the Company will continue as a going concern. The Company has sustained operating losses since
inception and expects such losses to continue as it furthers its research and development programs.

3. Summary of Significant Accounting Policies

Use of Estimates

The preparation of financial
statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosures of contingent assets
and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Significant management judgment is required to make estimates in relation to: the carrying value and
recoverability of intangible assets and property, plant and equipment; the recoverability of deferred income taxes; and the accruing of liabilities for clinical and preclinical development activities. Actual results could differ from those
estimates.



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Principles of Consolidation

The consolidated financial statements include the accounts of the Company and all subsidiaries. All significant intercompany accounts and transactions are eliminated.

Cash and Cash Equivalents

The Company invests its excess cash in bank deposits, money market accounts and bank
accepted commercial bills. The Company considers all highly liquid investments with an original maturity of 90 days or less at the time of purchase to be cash equivalents.

Bank accepted commercial bills are acquired at a discount to their face value. The bills are carried at cost plus a portion of the discount recognised as income on an effective yield basis. The discount brought to
account each period is accounted for as interest received.

Concentration of Credit Risk and Other Risks and Uncertainties

Cash and cash equivalents consist of financial instruments that potentially subject the Company to concentration of credit risk to the extent of the amount recorded on
the balance sheet. The Companys cash and cash equivalents are invested with three of Australias four largest banks. The Company is exposed to credit risk in the event of default by the banks holding the cash and cash equivalents to the
extent of the amount recorded on the balance sheets. The Company has not experienced any losses on its deposits of cash and cash equivalents.

Product
candidates developed by the Company may require approvals or clearances from the U.S. Food and Drug Administration (FDA) or other international regulatory agencies prior to commercialized sales. There can be no assurance that the
Companys product candidates will receive any of the required approvals or clearances. If the Company was denied approval or clearance or such approval was delayed, it may have a material adverse impact on the Company.

Foreign currency and currency transactions

Monetary assets and
liabilities in foreign currencies are translated into Australian dollars at the rate ruling at the date of transaction. Monetary assets and liabilities denominated in foreign currencies are retranslated into Australian dollars at the rate of
exchange ruling at the balance sheet date. Transaction gains and losses are recognized in the statement of operations. The Company has no assets denominated in foreign currencies and immediately settles liabilities denominated in foreign currencies.

The Company has recorded foreign currency transaction losses of $0, $5, $47 and $52 for each of the years ended June 30, 2005, 2006 and 2007, and the
period from inception to June 30, 2007, respectively. The Company has recorded foreign currency transaction gains of $0, $0, $0 and $2 for each of the years ended June 30, 2005, 2006 and 2007, and the period from inception to June 30,
2007, respectively.

The Companys functional and reporting currency is the Australian dollar.

Fair Value of Financial Instruments

For financial instruments
consisting of cash and cash equivalents, accounts payable and accrued liabilities included in the Companys financial statements, the carrying amounts are reasonable estimates of fair value due to their short maturities.

Property, Plant and Equipment

Property, plant and equipment are
recorded at acquisition cost, less accumulated depreciation and amortization. Depreciation and amortization are calculated on a straight-line basis over the estimated useful lives of the related assets, which are generally three to ten years.
Amortization of leasehold improvements is computed using the straight-line method over the shorter of the remaining lease term or the estimated useful life of the related assets, typically three years. Maintenance and repairs are charged to
operations as incurred.



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The Company receives grants under certain government research agreements to purchase plant and equipment. The grants are
recognized against the acquisition costs of the related plant and equipment as and when the related assets are purchased. Grants received in advance of the relevant expenditure are treated as deferred research grants and included in Other Accrued
Liabilities on the balance sheet as the Company does not control the monies until the relevant expenditure has been incurred. Grants due to the Company under research agreements are recorded as receivables and included on the balance sheet.

Impairment of Long-Lived Assets

The Company reviews
its capital assets, including patents and licenses, for impairment whenever events or changes in business circumstances indicate that the carrying amount of the assets may not be fully recoverable. In performing the review, the Company estimates
undiscounted cash flows from products under development that are covered by these patents and licenses. An impairment loss would be recognized when estimated undiscounted future cash flows expected to result from the use of the asset and its
eventual disposition is less than the carrying amount of the asset. Impairment, if any, is measured as the amount by which the carrying amount of the asset exceeds its fair value. Impairment, if any, is assessed using discounted cash flows. Related
patents are grouped in estimating future cash flows to determine whether patents are impaired and in measuring the amount of the impairment.,

Interest
Income

Interest revenue is recognized as it accrues, taking into account the effective yield on the financial instruments.

Research and Development

Research and development expenses consist
of costs incurred to further the Companys research and development activities and include salaries and related employee benefits, costs associated with clinical trials and preclinical development, regulatory activities, research-related
overhead expenses, costs associated with the manufacture of clinical trial material, costs associated with developing a commercial manufacturing process, costs for consultants and related contract research, facility costs and depreciation. Research
and development costs are expensed as incurred.

The Company has received grants under certain government research agreements that partially fund eligible
research expenditure on certain of the Companys research projects. The grants are recognized against the related research and development expenses as and when the relevant research expenditure is incurred. Grants received in advance of
incurring the relevant expenditure are treated as deferred research grants and included in Other Accrued Liabilities on the balance sheet as the Company does not control the monies until the relevant expenditure has been incurred. Grants due to the
Company under research agreements are recorded as receivables and included on the balance sheet.

Patent and License Costs

Costs to purchase patent licenses and application costs for new patents are capitalised and amortised over the life of the patent. All of the Companys patents and
licenses have finite lives with the remaining lives ranging from 9 to 20 years at June 30, 2007.

Clinical Trial Expenses

Clinical trial costs are a component of research and development expense. These expenses include fees paid to participating hospitals and other service providers, which
conduct certain product development activities on behalf of the Company. Depending on the timing of payments to the service providers and the level of service provided, the Company records prepaid or accrued expenses relating to these costs.

These prepaid or accrued expenses are based on estimates of the work performed under service agreements, milestones achieved, patient enrollment and
experience with similar contracts. Changes in these estimates are recognized in income in the period of change.



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Leased Assets

All of
the Companys leases for the years ended June 30, 2005, 2006, and 2007 are considered operating leases. The costs of operating leases are charged to the statement of operations on a straight-line basis over the lease term.

Pension Costs

As required by Australian law, the Company contributes
to standard defined contribution superannuation funds on behalf of all employees at an amount up to nine percent of each such employees salary. Superannuation is a compulsory savings program whereby employers are required to pay a portion of
an employees remuneration to an approved superannuation fund that the employee is typically not able to access until they are retired. The Company permits employees to choose an approved and registered superannuation fund into which the
contributions are paid. Contributions are charged to the statement of operations as they become payable.

Income Taxes

The Company applies Statement of Financial Accounting Standards No. 109  Accounting for Income Taxes (SFAS 109) which establishes financial accounting and
reporting standards for the effects of income taxes that result from a companys activities during the current and preceding years. Deferred tax assets and liabilities are recognized for the future tax consequences attributable to temporary
differences between the financial statement carrying amounts of assets and liabilities and their respective tax bases. Deferred tax assets also are recognized for credit carryforwards. Deferred tax assets and liabilities are measured using the
enacted rates applicable to taxable income in the years in which the temporary differences are expected to reverse and the credits are expected to be used. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in
income in the period that includes the enactment date. An assessment is made as to whether or not it is more likely than not that deferred tax assets are recoverable. This assessment includes anticipating future taxable income and the Companys
tax planning strategies and is made on an ongoing basis. Consequently, future material changes in the valuation allowance are possible.

Net Loss Per
Share and Anti-dilutive Securities

Basic and diluted net loss per share are presented in conformity with Statement of Financial Accounting Standards
No, 128  Earnings Per Share (SFAS 128). Basic and diluted net loss per share have been computed using the weighted-average number of ordinary shares outstanding during the period. All the share information presented for the period from
inception to June 30, 2007 have been retroactively adjusted to give effect to the 8 for 1 share split in November 2003. The potentially dilutive options issued under the Pharmaxis Employee Option Plan and the A and B
class convertible redeemable preference shares were not considered in the computation of diluted net loss per share because they would be anti-dilutive.

Sales Revenue

Sales revenue is measured at the fair value of the consideration received or receivable. Amounts disclosed as revenue are net
of returns and sales deductions such as discounts and incentives. Revenue from the sale of goods is recorded when goods have been dispatched and title passes to the customer.

Inventory

Raw materials, work in progress and finished goods are stated at the lower of cost or market. Cost
comprises direct materials, direct labour and an appropriate proportion of variable and fixed overhead expenditure, the latter being allocated on the basis of normal operating capacity. Costs are assigned to individual items of inventory on basis of
weighted average costs. Costs of purchased inventory are determined after deducting rebates and discounts.



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Stock-based Compensation

Prior to 2006, the Company accounted for stockbased compensation utilizing the fair value recognition provisions of SFAS No. 123. Under SFAS No. 123, stockbased compensation cost is measured at the grant date based on
the value of the award and is recognized as expense over the vesting period.

In December 2004, the Financial Accounting Standards Board (FASB) issued SFAS
No. 123R ShareBased Payment. SFAS No 123R is a revision of SFAS No. 123 Accounting for StockBased Compensation. Among other items, SFAS 123R requires companies to recognize the cost of employee services
received in exchange for awards of equity instruments, based on the grant date fair value of those awards, in the financial statements. The effective date of SFAS 123R is the first annual reporting period beginning after June 15, 2005. SFAS
123R permits companies to adopt its requirements using a modified prospective method. Under the modified prospective method, stock-based compensation is recognized for new awards, the modification, repurchase or cancellation
of awards, and the remaining portion of service under previously granted, unvested awards outstanding as of the date of adoption. Under the modified retrospective method, the requirements are the same as under the modified
prospective method, but also permits entities to restate financial statements of previous periods based on proforma disclosures made in accordance with SFAS 123. The Company adopted SFAS 123R beginning July 1, 2006 using the
modified prospective method therefore, prior periods were not restated. There were no transitional adjustments on adoption of SFAS 123(R)

Prior to 2006,
the Company utilized a standard option pricing model, such as BlackScholes, to measure the fair value of stock options granted to employees. The following assumptions were used to estimate the fair value of the options outstanding: dividend
yield and expected volatility of 50%, risk free rate between 5.15% and 6.45%, and expected lives of 6 years.

Effective July 1, 2006, the Company
continues to utilise the Black-Scholes model, and adopted the provisions of SFAS 123R using the graded-vesting attribution method. Under this method, the Company recognizes compensation cost related to service based awards ratably over the requisite
service period.

Staff Accounting Bulletin (SAB) 108

The SECs Staff Accounting Bulletin No. 108, Considering the Effects of Prior Year Misstatements When Quantifying Misstatements in Current Year Financial Statements (SAB 108) was adopted by the Company during the year
ended June 30, 2007 and did not have a material impact on our consolidated financial statements. SAB 108 requires the use of both the rollover method and the iron curtain method in evaluating materiality.

Recent Accounting Pronouncements

In June 2006, the
FASB issued FASB Interpretation No. 48 (FIN 48), Accounting for Uncertainty in Income Taxesan interpretation of FASB Statement No. 109, Accounting for Income Taxes, which clarifies the accounting for uncertainty in income
taxes. FIN 48 prescribes a recognition threshold and measurement attribute for the financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. The Interpretation requires that the Company
recognize in the financial statements, the impact of a tax position, if that position is more likely than not of being sustained on audit, based on the technical merits of the position. FIN 48 also provides guidance on derecognition, classification,
interest and penalties, accounting in interim periods and disclosure. The provisions of FIN 48 are effective for the first fiscal year beginning after December 15, 2006 with the cumulative effect of the change in accounting principle recorded
as an adjustment to opening retained earnings. We are currently evaluating the possible impact of FIN 48 on our consolidated financial statements which we will adopt as of July 1, 2007.

In September 2006, the FASB issued Statement of Financial Accounting Standards No. 157, Fair Value Measurements (SFAS No. 157). This Statement
defines fair value as used in numerous accounting pronouncements, establishes a framework for measuring fair value in generally accepted accounting principles (GAAP) and expands disclosure related to the use of fair value measures in financial
statements. SFAS No. 157 does not expand the use of fair value measures in financial statements, but standardizes its definition and guidance in GAAP. The Standard emphasizes that fair value is a market-based measurement and not an
entity-specific measurement based on an exchange transaction in which the entity sells an asset or transfers a liability (exit price). SFAS No. 157 establishes a fair value hierarchy from observable market data as the highest level to fair
value based



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on an entitys own fair value assumptions as the lowest level. The Statement is to be effective for our financial statements issued in 2008; however,
earlier application is encouraged. We believe that SFAS No. 157 will not have a material impact on our consolidated financial statements.

4.
Property, Plant and Equipment

Property, plant and equipment consist of the following:



|                                          |  |                |        |   |      |   |        |  
|----------------------------------------- |  | -------------- | ------ | - | ---- | - | ------ | -
|                                          |  | As of June 30, |       
|                                          |  | 2006           |        |   | 2007 |  
|                                          |  | (in thousands) |       
|Plant and equipment                       |  | $              | 4,772  |   |      | $ | 5,863  |  
|Leasehold improvements                    |  |                | 162    |   |      |   | 354    |  
|Motor vehicles                            |  |                | 114    |   |      |   | 45     |  
|Capital work in process                   |  |                |       |   |      |   |       |  
|                                          |  |                |        |   |      |   |        |  
|                                          |  |                | 5,048  |   |      |   | 6,262  |  
|Accumulated depreciation and amortization |  |                | (1,759 | ) |      |   | (2,510 | )
|                                          |  |                |        |   |      |   |        |  
|Property, plant and equipment, net        |  | $              | 3,289  |   |      | $ | 3,752  |  
|                                          |  |                |        |   |      |   |        |  

Depreciation and amortization expense was $489, $763, $797 and $2,624 for the fiscal years ended June 30,
2005, 2006 and 2007, and the period from inception to June 30, 2007, respectively. The 2006 expense includes an impairment charge of $109 in relation to an item of plant & equipment that was taken out of service.

5. Intangible Assets

Intangible assets consist of the following:



|                         |  |                |       |   |      |   |       |  
|------------------------ |  | -------------- | ----- | - | ---- | - | ----- | -
|                         |  | As of June 30, |      
|                         |  | 2006           |       |   | 2007 |  
|                         |  | (in thousands) |      
|Patent license           |  | $              | 1,400 |   |      | $ | 1,400 |  
|Patent applications      |  |                | 174   |   |      |   | 208   |  
|Trademark applications   |  |                | 59    |   |      |   | 65    |  
|                         |  |                |       |   |      |   |       |  
|                         |  |                | 1,633 |   |      |   | 1,673 |  
|Accumulated amortization |  |                | (576  | ) |      |   | (671  | )
|                         |  |                |       |   |      |   |       |  
|Intangible assets, net   |  | $              | 1,057 |   |      | $ | 1,002 |  
|                         |  |                |       |   |      |   |       |  

The patent license was acquired in October 1999 from Anutech Pty Limited, an agent for the Australian National
University. A license to the acquired technology was previously held by Praxis Pharmaceuticals Inc, a related party. The license was granted to Pharmaxis Ltd by Anutech at the request of Praxis Pharmaceuticals Inc, in consideration for which Praxis
Pharmaceuticals Inc was issued 1.4 million ordinary shares in the Company. The license was included in long-term assets on the balance sheet at its estimated fair value of $1,400 at the time of the purchase. The patents underlying the license
relate to potential treatments for autoimmune diseases. The license is an exclusive, worldwide sub-licensable license within the field of phosphosugars as ethical therapeutics. A royalty is payable to Anutech, calculated based on revenue, net of
expenses, received by the Company in connection with the Companys use of the related intellectual property. In addition the Company must reimburse Anutech for one third of any costs incurred in filing, maintaining and renewing the patents
underlying the license. Trademark applications included registration of the Aridol and Bronchitol names. The 2006 amortization expense of $137 includes an impairment charge of $46 in relation to Patent Family 6 which was
allowed to lapse.



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6. Other Accrued Liabilities

Other accrued liabilities consist of the following:



|                          |  |                |     |      |   |    
|------------------------- |  | -------------- | --- | ---- | - | ---
|                          |  | As of June 30,
|                          |  | 2006           |     | 2007
|                          |  | (in thousands)
|Deferred research grants  |  | $              |    |      | $ |   
|Legal and accounting fees |  |                | 199 |      |   | 281
|Manufacturing consultants |  |                | 253 |      |   | 249
|Other                     |  |                | 198 |      |   | 325
|                          |  |                |     |      |   |    
|                          |  | $              | 650 |      | $ | 855
|                          |  |                |     |      |   |    

7. Sydney South West Area Health Service (SSWAHS) License

In October 2001 the Company obtained an exclusive, worldwide sub-licensable license from SSWAHS in relation to certain patents in the area of respiratory disease. The
term of the SSWAHS license is country specific and is for the longer of 10 years from the first commercial sale of products which exploits the SSWAHS intellectual property in that country until the expiry of the last registered patent in that
country. The Company must bear the cost of maintaining the registered SSWAHS intellectual property and must use its reasonable commercial endeavors to exploit and undertake research and development of the SSWAHS intellectual property. Royalties are
payable by the Company to SSWAHS for the term of the SSWAHS license on net sales of products and services which exploit the SSWAHS intellectual property. No amounts were paid or are payable under the license.

8. Ordinary Shares

In fiscal 2004, as part of the transition to an
Australian listed public company, shareholders approved an 8 for 1 share split of all A and B class convertible redeemable preference shares, ordinary shares and other securities; a change in the Companys status from a
proprietary to a public company; the adoption of a new constitution; and, following the share split all A and B class convertible redeemable preference shares were converted to ordinary shares. Before the 8 for 1 share split
the Company had on issue 1,400,000 ordinary shares, 2,000,000 A class convertible redeemable preference shares and 3,852,000 B class convertible redeemable preference shares. After the 8 for 1 share split there were
11,200,000 ordinary shares, 16,000,000 A class convertible redeemable preference shares and 30,816,000 B class convertible redeemable preference shares. After the conversion the Company had 50,816,000 ordinary shares. All
share and per share amounts for the fiscal years 2004 and the period from inception to June 30, 2007 presented in the accompanying financial statements have been retroactively adjusted to give effect to the share split.

The Company completed its initial public offering and listed on the Australian Securities Exchange on November 10, 2003, issuing 50 million shares and raising
$25,000 before costs associated with the issue.

In fiscal 2005 the Company issued 22 million ordinary shares in a private placement to institutional
and sophisticated investors, 4,362,092 ordinary shares in a share purchase plan offered to existing shareholders, and 372,000 ordinary shares upon the exercise of employee options.

In fiscal 2006 the Company completed a public offering of 19,500,000 ordinary shares in the form of 1,300,000 American Depositary Shares in the United States. Concurrently the Company placed 19,900,000 ordinary shares
in Australia to institutional and sophisticated investors. The Company further issued 2,733,500 ordinary shares upon the exercise of employee options.

In
fiscal 2007 the Company issued 1,045,625 ordinary shares upon the exercise of employee options. At June 30, 2007 the Company had 177,949,217 ordinary shares on issue.

Ordinary shares entitle the holder to participate in dividends and the proceeds on winding up of the Company in proportion to the number of and amounts paid on the shares held. At a general meeting every shareholder
present (in



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person or by proxy, attorney or representative) has one vote on a show of hands. Every shareholder present (in person or by proxy, attorney or
representative) has one vote per fully paid share on a poll.

9. Convertible Redeemable Preference Shares

Up until the time of the Companys Australian initial public offering, the Company had on issue 16,000,000 A and 30,816,000 B class
convertible redeemable preference shares.

The Company issued 29,920,000 B class convertible redeemable preference shares on August 28,
2002 and 896,000 B class convertible redeemable preference shares on May 2, 2003, raising a total of $9,600 in 2003 before costs associated with the issues.

The A and B class convertible redeemable preference shares were convertible by the holders into ordinary shares at any time or could be compulsorily converted at the time of an initial public
offering, subject to certain conditions. The conversion ratio was one ordinary share per convertible redeemable preference share, subject to variation for capital reconstructions and share dilutions.

The holders of the A and B class convertible redeemable preference shares could redeem their shares after October 15, 2005 if the Company
had not listed on a securities exchange, on the winding up of the Company, or the disposal of its business or on a voluntary merger of the Company. The redemption price payable to the holders was their original issue price adjusted for any capital
reconstructions plus any unpaid accrued cumulative dividends and a prorata share of surplus assets and profits at redemption date. On redemption B class convertible redeemable preference shares had priority over A class
shares.

Both A and B class convertible redeemable preference shares were entitled to a 10% per annum cumulative dividend
(based on original issue prices), B class having priority over A class. The dividends were only payable on the occurrence of a defined liquidity event or a voluntary merger of the Company. The dividend was not accrued as the
events requiring the dividend to be paid were considered uncertain to occur and not probable. All rights to preference dividends lapsed upon the Companys Australian listing in November 2003.

10. Stock Option Plan

The Pharmaxis Employee Option Plan
(EOP) was approved by shareholders in 1999 and amended by shareholders in June 2003. The maximum number of options available to be issued under the EOP is 15% of total issued shares including the EOP. All employees and directors are
eligible to participate in the EOP, but do so at the invitation of the Board. The terms of option issues are determined by the Board. Options are generally granted for no consideration and have a life of ten years. Options granted to executives and
employees generally vest equally over a four year period. For options granted after January 1, 2003 the annual vesting is subject to approval by the Remuneration and Nomination Committee of the Board. The Committee gives its approval for
vesting based on the achievement of individual employees personal annual objectives. Independent non-executive directors are granted options on joining the Board and from fiscal 2006 are allowed to package their remuneration to include options
in the company. Options granted to directors upon joining the Board and options granted before fiscal 2006 vest over a period of approximately four years. Other options granted to non-executive directors vest in the year of grant. Upon a Liquidity
Event, all unvested awards will become immediately exercisable. A Liquidity Event is defined as a response issued by the Company in respect of a takeover offer for all the shares of the Company.

Options granted under the EOP carry no dividend or voting rights. When exercisable, each option is convertible into one ordinary share.

The exercise price is set by the Board. Before the Company listed on the Australian Securities Exchange (ASX) in November 2003, the Board set the exercise
price based on its assessment of the market value of the underlying shares at the time of grant. Since listing the exercise price is set as the average closing price of Pharmaxis Ltd shares on the Australian Securities Exchange on the five business
days prior to the grant of the options.

A total of 4,171,125 options have been exercised to June 30, 2007, of which 2,733,500 were exercise in fiscal
2006 and 1,045,625 were exercise in fiscal 2007.



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##### Table of Contents

There were 7,826,645 vested options at June 30, 2007 (7,772,625 at June 30, 2006) with a weighted average
exercise price of $0.512 ($0.362 at June 30, 2006). The average remaining life of options outstanding at June 30, 2007 is 6.01 years (6.52 years at June 30, 2006). All share and option amounts for the fiscal years 2004 and for the
period from inception to June 30, 2007 have been retroactively adjusted to give effect to the share split described in note 9 above.

The following
table summarizes stock option activity under the EOP:



|                         |  |                    |   |  |                                |       |                            |   |      
|------------------------ |  | ------------------ | - |  | ------------------------------ | ----- | -------------------------- | - | -----
|                         |  | OptionsOutstanding |   |  | Weighted-AverageExercise Price |       | Weighted-AverageFair Value
|Options granted          |  | 2,400,000          |   |  | $                              | 0.125 |                            | $ | 0.070
|                         |  |                    |   |  |                                |       |                            |   |      
|Balance at June 30, 2000 |  | 2,400,000          |   |  | $                              | 0.125 |                            | $ | 0.070
|Options granted          |  | 640,000            |   |  | $                              | 0.125 |                            | $ | 0.069
|                         |  |                    |   |  |                                |       |                            |   |      
|Balance at June 30, 2001 |  | 3,040,000          |   |  | $                              | 0.125 |                            | $ | 0.070
|Options granted          |  | 800,000            |   |  | $                              | 0.275 |                            | $ | 0.044
|                         |  |                    |   |  |                                |       |                            |   |      
|Balance at June 30, 2002 |  | 3,840,000          |   |  | $                              | 0.156 |                            | $ | 0.065
|Options granted          |  | 5,344,000          |   |  | $                              | 0.313 |                            | $ | 0.168
|Options cancelled/lapsed |  | (160,000           | ) |  | $                              | 0.125 |                            | $ | 0.070
|                         |  |                    |   |  |                                |       |                            |   |      
|Balance at June 30, 2003 |  | 9,024,000          |   |  | $                              | 0.249 |                            | $ | 0.126
|Options granted          |  | 1,750,000          |   |  | $                              | 0.340 |                            | $ | 0.187
|Options cancelled/lapsed |  | (23,000            | ) |  | $                              | 0.440 |                            | $ | 0.234
|                         |  |                    |   |  |                                |       |                            |   |      
|Balance at June 30, 2004 |  | 10,751,000         |   |  | $                              | 0.264 |                            | $ | 0.136
|Options granted          |  | 605,000            |   |  | $                              | 1.005 |                            | $ | 0.548
|Options cancelled/lapsed |  | (50,000            | ) |  | $                              | 0.43  |                            | $ | 0.228
|Options exercised        |  | (392,000           | ) |  | $                              | 0.159 |                            | $ | 0.102
|                         |  |                    |   |  |                                |       |                            |   |      
|Balance at June 30, 2005 |  | 10,914,000         |   |  | $                              | 0.308 |                            | $ | 0.160
|Options granted          |  | 1,541,000          |   |  | $                              | 1.990 |                            | $ | 1.455
|Options cancelled/lapsed |  | (30,000            | ) |  | $                              | 1.287 |                            | $ | 0.804
|Options exercised        |  | (2,733,500         | ) |  | $                              | 0.218 |                            | $ | 0.120
|                         |  |                    |   |  |                                |       |                            |   |      
|Balance at June 30, 2006 |  | 9,691,500          |   |  | $                              | 0.597 |                            | $ | 0.375
|Options granted          |  | 1,518,457          |   |  | $                              | 2.215 |                            | $ | 1.531
|Options cancelled/lapsed |  | (328,625           | ) |  | $                              | 2.113 |                            | $ | 1.437
|Options exercised        |  | (1,045,625         | ) |  | $                              | 0.347 |                            | $ | 0.198
|                         |  |                    |   |  |                                |       |                            |   |      
|Balance at June 30, 2007 |  | 9,835,707          |   |  | $                              | 0.823 |                            | $ | 0.537

The Company recorded stock compensation expense of $260, $1,124 and $1,488, and $4,009 in the fiscal years ended
June 30, 2005, 2006 and 2007, and the period from inception to June 30, 2007.

In accordance with SFAS 123(R), the fair values of the option
grants were estimated on the date of each grant using the Black-Scholes option pricing model. The assumptions for these grants were:



|                  |  |                |        |                          |   |            |  |    |               |  |                        |  |      |  
|----------------- |  | -------------- | ------ | ------------------------ | - | ---------- |  | -- | ------------- |  | ---------------------- |  | ---- | -
|Grant Date        |  | Exercise Price |        | Share Price atGrant Date |   | Volatility |  |    | Expected Life |  | Risk FreeInterest Rate | 
|December 1, 1999  |  | $              | 0.125  |                          | $ | 0.125      |  | 50 | %             |  | 6 years                |  | 6.45 | %
|July 1, 2000      |  | $              | 0.125  |                          | $ | 0.125      |  | 50 | %             |  | 6 years                |  | 6.03 | %
|January 1, 2001   |  | $              | 0.125  |                          | $ | 0.125      |  | 50 | %             |  | 6 years                |  | 5.31 | %
|September 1, 2001 |  | $              | 0.3125 |                          | $ | 0.125      |  | 50 | %             |  | 6 years                |  | 5.29 | %
|December 2, 2001  |  | $              | 0.125  |                          | $ | 0.125      |  | 50 | %             |  | 6 years                |  | 5.26 | %
|May 12, 2003      |  | $              | 0.3125 |                          | $ | 0.3125     |  | 50 | %             |  | 6 years                |  | 5.26 | %
|July 1, 2003      |  | $              | 0.3125 |                          | $ | 0.3125     |  | 50 | %             |  | 6 years                |  | 4.85 | %
|July 4, 2003      |  | $              | 0.3125 |                          | $ | 0.3125     |  | 50 | %             |  | 6 years                |  | 4.85 | %
|December 9, 2003  |  | $              | 0.376  |                          | $ | 0.376      |  | 50 | %             |  | 6 years                |  | 5.68 | %
|April 25, 2004    |  | $              | 0.508  |                          | $ | 0.508      |  | 50 | %             |  | 6 years                |  | 5.62 | %
|June 4, 2004      |  | $              | 0.426  |                          | $ | 0.426      |  | 50 | %             |  | 6 years                |  | 5.56 | %



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##### Table of Contents

|                   |  |                |       |                           |   |            |  |    |               |  |                         |  |      |  
|------------------ |  | -------------- | ----- | ------------------------- | - | ---------- |  | -- | ------------- |  | ----------------------- |  | ---- | -
|February 2, 2005   |  | $              | 0.834 |                           | $ | 0.834      |  | 50 | %             |  | 6 years                 |  | 5.57 | %
|May 12, 2005       |  | $              | 1.147 |                           | $ | 1.147      |  | 50 | %             |  | 6 years                 |  | 5.15 | %
|August 5, 2005     |  | $              | 1.790 |                           | $ | 1.790      |  | 50 | %             |  | 6 years                 |  | 5.31 | %
|October 17, 2005   |  | $              | 2.772 |                           | $ | 2.772      |  | 50 | %             |  | 6 years                 |  | 5.46 | %
|November 15, 2005  |  | $              | 1.790 |                           | $ | 2.300      |  | 50 | %             |  | 6 years                 |  | 5.48 | %
|February 13, 2006  |  | $              | 2.194 |                           | $ | 2.194      |  | 50 | %             |  | 6 years                 |  | 5.29 | %
|                   |  |                |       |                           |  
|Grant Date         |  | Exercise Price |       | Share Price at Grant Date |   | Volatility |  |    | Expected Life |  | Risk Free Interest Rate | 
|June 1, 2006       |  | $              | 2.034 |                           | $ | 2.034      |  | 50 | %             |  | 6 years                 |  | 5.74 | %
|August 15, 2006    |  | $              | 1.917 |                           | $ | 1.917      |  | 50 | %             |  | 6 years                 |  | 5.93 | %
|October 26, 2006   |  | $              | 1.917 |                           | $ | 1.917      |  | 50 | %             |  | 6 years                 |  | 5.73 | %
|September 20, 2006 |  | $              | 1.892 |                           | $ | 1.892      |  | 50 | %             |  | 6 years                 |  | 5.62 | %
|October 26, 2006   |  | $              | 2.068 |                           | $ | 2.068      |  | 50 | %             |  | 6 years                 |  | 5.73 | %
|December 14, 2006  |  | $              | 3.071 |                           | $ | 3.071      |  | 50 | %             |  | 6 years                 |  | 5.73 | %
|June 18, 2007      |  | $              | 3.316 |                           | $ | 3.316      |  | 50 | %             |  | 6 years                 |  | 6.27 | %

The following table presents information relating to stock options outstanding under the plans as of June 30,
2007:



|               |        |                     |           |                                         |      |        |          
|-------------- | ------ | ------------------- | --------- | --------------------------------------- | ---- | ------ | ---------
|               |        | Options Outstanding |           | Options Exercisable                    
|Exercise Price |        | Shares              |           | Weighted AverageRemaining Life in Years |      | Shares
|$              | 0.125  |                     | 1,220,000 |                                         | 2.59 |        | 1,220,000
|$              | 0.3125 |                     | 4,818,000 |                                         | 5.06 |        | 4,818,000
|$              | 0.376  |                     | 500,000   |                                         | 6.42 |        | 500,000  
|$              | 0.508  |                     | 22,500    |                                         | 6.82 |        | 15,000   
|$              | 0.426  |                     | 15,000    |                                         | 6.93 |        | 11,250   
|$              | 0.834  |                     | 240,000   |                                         | 7.60 |        | 147,500  
|$              | 1.147  |                     | 320,000   |                                         | 7.87 |        | 185,000  
|$              | 1.790  |                     | 800,000   |                                         | 8.10 |        | 400,000  
|$              | 2.772  |                     | 70,000    |                                         | 8.30 |        | 35,000   
|$              | 2.194  |                     | 270,000   |                                         | 8.63 |        | 67,500   
|$              | 2.034  |                     | 96,500    |                                         | 8.93 |        | 24,125   
|$              | 1.917  |                     | 906,207   |                                         | 9.13 |        | 323,270  
|$              | 1.892  |                     | 47,500    |                                         | 9.23 |        | 11,875   
|$              | 2.068  |                     | 200,000   |                                         | 8.72 |        | 50,000   
|$              | 3.071  |                     | 72,500    |                                         | 9.46 |        | 18,125   
|$              | 3.316  |                     | 237,500   |                                         | 9.97 |        |         

The following table presents information relating to stock options outstanding under the plans as of June 30,
2006:



|               |        |                     |           |                                         |     |        |          
|-------------- | ------ | ------------------- | --------- | --------------------------------------- | --- | ------ | ---------
|               |        | Options Outstanding |           | Options Exercisable                    
|Exercise Price |        | Shares              |           | Weighted AverageRemaining Life in Years |     | Shares
|$              | 0.125  |                     | 1,340,000 |                                         | 3.7 |        | 1,340,000
|$              | 0.3125 |                     | 5,698,000 |                                         | 6.1 |        | 5,474,000
|$              | 0.376  |                     | 500,000   |                                         | 7.4 |        | 437,500  
|$              | 0.508  |                     | 22,500    |                                         | 7.8 |        | 7,500    
|$              | 0.426  |                     | 15,000    |                                         | 7.9 |        | 7,500    
|$              | 0.834  |                     | 255,000   |                                         | 8.6 |        | 108,750  
|$              | 1.147  |                     | 330,000   |                                         | 8.9 |        | 120,000  
|$              | 1.790  |                     | 954,500   |                                         | 9.1 |        | 238,625  
|$              | 2.772  |                     | 155,000   |                                         | 9.3 |        | 38,750   
|$              | 2.194  |                     | 310,000   |                                         | 9.6 |        |         
|$              | 2.034  |                     | 111,500   |                                         | 9.9 |        |         



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##### Table of Contents

11. Retirement Benefits

As required by Australian law, the Company contributes to standard defined contribution superannuation funds on behalf of all employees at an amount up to nine percent of employee salary. The Company permits employees to choose the
superannuation fund into which the contributions are paid, provided the fund is appropriately registered.

The Company contributed $196, $337 and $454, and
$1,182 for the fiscal years ended June 30, 2005, 2006 and 2007, and the period from inception to June 30, 2007, respectively.

12. Income
Taxes

The Company has made a taxable loss in each of the operating periods since incorporation.

A reconciliation of the (benefit) provision for income taxes with the amount computed by applying the statutory company tax rate of 30% to the loss before income taxes
is as follows:



|                                                              |  |                      |         |   |                                       |     |   |      |   |         |   |  |     |   |  |   |         |   |  |     |   |  |   |         |   |  |     |  
|------------------------------------------------------------- |  | -------------------- | ------- | - | ------------------------------------- | --- | - | ---- | - | ------- | - |  | --- | - |  | - | ------- | - |  | --- | - |  | - | ------- | - |  | --- | -
|                                                              |  | Years ended June 30, |         |   | Period frominception to June 30, 2007 |    
|                                                              |  | 2005                 |         |   | 2006                                  |     |   | 2007 |   |        
|                                                              |  | (in thousands)       |        
|                                                              |  | $                    |         |   |                                       | %   |   |      | $ |         |   |  | %   |   |  | $ |         |   |  | %   |   |  | $ |         |   |  | %   |  
|Loss before income taxes                                      |  |                      | (10,445 | ) |                                       |     |   |      |   | (17,728 | ) |  |     |   |  |   | (24,160 | ) |  |     |   |  |   | (62,760 | ) |  |     |  
|Income tax expense computed at statutory corporation tax rate |  |                      | (3,134  | ) |                                       | 30  |   |      |   | (5,320  | ) |  | 30  |   |  |   | (7,248  | ) |  | 30  |   |  |   | (18,830 | ) |  | 30  |  
|Research & development incentive                              |  |                      | (819    | ) |                                       | 8   |   |      |   | (1,556  | ) |  | 9   |   |  |   | (1,900  | ) |  | 8   |   |  |   | (4,275  | ) |  | 7   |  
|Disallowed expenses                                           |  |                      |         |   |                                       |     |   |      |   |         |   |  |     |   |  |   |         |   |  |     |   |  |   |         |   |  |     |  
|Stock option expense                                          |  |                      | 78      |   |                                       | (1  | ) |      |   | 337     |   |  | (2  | ) |  |   | 446     |   |  | (2  | ) |  |   | 1,202   |   |  | (1  | )
|Amortization of intangible assets                             |  |                      | 25      |   |                                       |    |   |      |   |        |   |  |    |   |  |   |        |   |  |    |   |  |   | 140     |   |  |    |  
|Other                                                         |  |                      | 3       |   |                                       |    |   |      |   | (379    | ) |  | 2   |   |  |   | (252    | ) |  | 1   |   |  |   | (626    | ) |  | (  | )
|Change in valuation allowance                                 |  |                      | 3,847   |   |                                       | (37 | ) |      |   | 6,923   |   |  | (39 | ) |  |   | 8,973   |   |  | (37 | ) |  |   | 22,413  |   |  | (36 | )
|                                                              |  |                      |         |   |                                       |     |   |      |   |         |   |  |     |   |  |   |         |   |  |     |   |  |   |         |   |  |     |  
|Income tax expense                                            |  | $                    |        |   |                                       |    |   |      | $ | 5       |   |  |    |   |  | $ | 19      |   |  |    |   |  | $ | 24      |   |  |    |  
|                                                              |  |                      |         |   |                                       |     |   |      |   |         |   |  |     |   |  |   |         |   |  |     |   |  |   |         |   |  |     |  

Significant components of the Companys deferred tax assets are shown below:



|                                                        |  |                |   |  |         |  
|------------------------------------------------------- |  | -------------- | - |  | ------- | -
|                                                        |  | As of June 30, |  
|                                                        |  | 2006           |   |  | 2007    |  
|                                                        |  | (in thousands) |  
|Deferred tax assets (liabilities):                      |  |                |   |  |         |  
|Net operating loss carryforwards                        |  | 14,364         |   |  | 23,766  |  
|Interest and grant receivable                           |  |               |   |  | (231    | )
|Accrued compensation costs                              |  | 105            |   |  | 156     |  
|Research grants offset to property, plant and equipment |  | 16             |   |  | 2       |  
|Share issue expenses                                    |  | 2,313          |   |  | 1,637   |  
|                                                        |  |                |   |  |         |  
|Total deferred tax assets                               |  | 16,798         |   |  | 25,330  |  
|Valuation allowance for deferred tax assets             |  | (16,798        | ) |  | (25,330 | )
|                                                        |  |                |   |  |         |  
|Net deferred taxes                                      |  |               |   |  |        |  
|                                                        |  |                |   |  |         |  

Deferred income taxes reflect the net tax effect of temporary differences between the carrying amounts of assets
and liabilities for financial reporting and tax purposes. A valuation allowance has been established, as realization of such assets is not more likely than not.

At June 30, 2007 the Company has $79.2 million ($47.9 million at June 30, 2006) of accumulated tax losses available for carry forward against future earnings, which under Australian tax laws do not expire but may not be available
under certain circumstances.



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##### Table of Contents

13. Commitments and Contingent Liabilities

Operating leases

In August 2006, the Company renewed its operating lease for its headquarters and manufacturing
facilities in Frenchs Forest, Sydney, Australia. The operating lease expires in June 2011, with an option to renew for a further five years thereafter. The Companys bankers have issued a bank guarantee of $177 in relation to a rental bond to
secure the payments under the lease. This bank guarantee is secured by a security deposit held at the bank. The Company also leases equipment from time to time as required. During 2006 the Company entered into operating leases for additional offsite
storage space and a small suite of laboratories. Both leases expire within five years.

The Company recognized rent expense of $327, $371 and $459, and
$1,802 for the fiscal years ended June 30, 2005, 2006 and 2007, and the period from inception to June 30, 2007, respectively.

Future minimum
lease payments under all non-cancelable operating leases are as follows:



|                                      |  |   |      
|------------------------------------- |  | - | -----
|Years ending June 30,                 |  |   |      
|2008                                  |  |   | 401  
|2009                                  |  |   | 346  
|2010                                  |  |   | 357  
|2011 and thereafter                   |  |   | 368  
|                                      |  |   |      
|Total minimum lease payments required |  | $ | 1,472
|                                      |  |   |      

Government research grants

The Company has received three separate Australian Government research grants under the R&D START Program; All of these grant programs were completed by June 30, 2007. The Government may require the Company
to repay all or some of the amount of a particular grant together with interest in either of the following circumstances:



| |  |  | the Company fails to use its best endeavors to commercialise the relevant grant project within a reasonable time of completion of the project; or
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | upon termination of a grant due to breach of agreement or insolvency.
| | - |  | ---------------------------------------------------------------------

Technical failure of the grant funded research project does not of itself constitute failure to use best efforts to commercialise the relevant grant project. The grants have funded certain aspects of the
Companys development projects for the Aridol asthma product, multiple sclerosis and cystic fibrosis. The Company continues the development of all three projects funded by the START Program and has commenced commercialisation of its asthma
project as evidenced by the commencement of sales of Aridol in Australia. The Company believes that the likelihood of being required to repay grant funding is remote while the Company continues to act in good faith with respect to the grants. The
total amount received under the START Program at June 30, 2007 was $4,708.

The Company has been awarded a research grant under the Australian
Governments Pharmaceuticals Partnerships Program (P3). The Government may require the Company to repay all or some of the amount of the grant together with interest in any of the following circumstances:

a) the Government determines that expenditures claimed on research projects do not meet the P3 guidelines; or

b) upon termination of the grant due to breach of agreement, change in control of the Company or insolvency.

The total amount received under the P3 Program at June 30, 2007 was $2,803.

14. Research Grants

Research grants received have been accounted for as follows:



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##### Table of Contents

|                                                                       |  |                      |       |                                       |   |       |  |   |       |  |   |      
|---------------------------------------------------------------------- |  | -------------------- | ----- | ------------------------------------- | - | ----- |  | - | ----- |  | - | -----
|                                                                       |  | Years ended June 30, |       | Period frominception to June 30, 2007
|                                                                       |  | 2005                 |       | 2006                                  |   | 2007  | 
|Recognized against related research and development expenses           |  | $                    | 1,132 |                                       | $ | 1,245 |  | $ | 1,955 |  | $ | 7,751
|Recognized against the acquisition cost of related plant and equipment |  |                      |      |                                       |   |      |  |   |      |  |   | 225  
|                                                                       |  |                      |       |                                       |   |       |  |   |       |  |   |      
|                                                                       |  | $                    | 1,132 |                                       | $ | 1,245 |  | $ | 1,955 |  | $ | 7,976
|                                                                       |  |                      |       |                                       |   |       |  |   |       |  |   |      

Grants received in advance of incurring the relevant expenditure are treated as deferred research grants and
included in Other Accrued Liabilities on the balance sheet as the Company does not control the monies until the relevant expenditure has been incurred. Grants due to the Company under research agreements are recorded as receivables and included on
the balance sheet.

15. Guarantees and Indemnifications

Pharmaxis Ltd has entered into Deeds of Access to Documents and Indemnity agreements with certain executive officers and each of its directors. Each deed provides each respective officer with the following:



| |  |  | a right to access certain board papers of the Company during the period of their tenure and for a period of seven years after that tenure ends;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | subject to the Corporations Act, an indemnity in respect of liability to persons other than the Company and its related bodies corporate that they may incur while
acting in their capacity as an officer of the Company or a related body corporate, except where that liability involves a lack of good faith and for defending certain legal proceedings; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the requirement that the Company maintain appropriate directors and officers insurance for the officer.
| | - |  | ---------------------------------------------------------------------------------------------------------

No liability has arisen under these indemnities as at June 30, 2007.

16. Net Loss per Share

Basic net loss per ordinary share was computed by dividing the net loss applicable to ordinary shares by the
weighted-average number of ordinary shares and contingently issuable shares outstanding during the period. Diluted net loss per ordinary share was computed by dividing the net loss applicable to ordinary shares by the weighted-average number of
ordinary shares and contingently issuable shares outstanding during the period. Options granted to employees under the Pharmaxis Employee Option Plan are considered to be potential ordinary shares for the purpose of calculating diluted net loss per
share. However, all such issued options outstanding were not included in the calculation of diluted net loss per share as the effect of including such options is anti-dilutive.



|                                                                                                                        |  |                      |  |             |  |            
|----------------------------------------------------------------------------------------------------------------------- |  | -------------------- |  | ----------- |  | -----------
|                                                                                                                        |  | Years ended June 30,
|                                                                                                                        |  | 2005                 |  | 2006        |  | 2007       
|Weighted average number of ordinary shares used as the denominator in calculating basic and diluted net loss per share. |  | 123,933,133          |  | 160,349,332 |  | 177,285,390
|                                                                                                                        |  |                      |  |             |  |            

17. Segments

The Company operates in one segment. The principal activities of the Company are the research, development and commercialization of pharmaceutical products.

The Company operates predominantly in one geographical area, being Australia.



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##### Table of Contents

18. Subsequent Events

On August 13, 2007 the Company announced that the directors granted 1,886,000 options under the Pharmaxis Employee Option Plan. The terms of the options granted under the Plan are set out in note 10. The exercise price was calculated
as $3.389. The 2007 Company annual meeting approved the grant of 150,000 options to directors included in the August 13 grant. The 2007 Company annual meeting also approved the grant of 200,000 options to Dr John Villiger with an exercise price
of $3.226.

On November 6, 2007 the Company issued 527,000 options under the Pharmaxis Employee Option Plan to 14 recently hired employees. The
options have an exercise price of $4.2900.

On October 11, 2007 the Company announced a A$50 million placement to institutions and sophisticated
investors at A$3.90 per share. At the same time the Company announced a share purchase plan whereby each shareholder could subscribe for up to A$5,000 worth of Pharmaxis Ltd shares at an issue price of A$3.90. The share purchase plan closed on
November 9, 2007 and raised $11.7 million.

On August 29, 2007 the Company announced positive results from its Phase III clinical trial of
Bronchitol for bronchiectasis.

On October 30, 2007 the Company entered into an agreement concerning the lease of a custom designed manufacturing,
warehousing and office facility. Construction of the new facility is expected to commence in the fourth quarter of 2007 and is expected to take over twelve months to complete. The Company expects to spend approximately $20 million fitting out the
facility and installing expanded manufacturing capacity.

On November 6, 2007 the Company incorporated a U.S. subsidiary, Pharmaxis, Inc. The
subsidiary provides sales, marketing and clinical trial management services to Pharmaxis Ltd on a cost-plus basis.

19. Subsidiary Company

On February 3, 2006 the Company incorporated a subsidiary in the United Kingdom at a cost that rounds to nil. The subsidiary provides sales,
marketing and clinical trial management services to Pharmaxis Ltd on a cost-plus basis.



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##### Table of Contents

Pharmaxis Ltd

(A Development Stage Enterprise)

Schedule II  Valuation and Qualifying Accounts

(for the years ended
June 30, 2003, 2004, 2005, 2006 and 2007 and for the period

from inception (May 29, 1998) to June 30, 2007)

(in A$ thousands, except share and per share amounts)



|                                        |  |                              |  |                             |  |                            |   |  |            |  |                       
|--------------------------------------- |  | ---------------------------- |  | --------------------------- |  | -------------------------- | - |  | ---------- |  | ----------------------
|                                        |  |                              |  | Additions                   |  |                            |   |  |           
|Description at                          |  | Balance atBeginningof Period |  | Charged toCosts andExpenses |  | Charged toOtherAccounts(1) |   |  | Deductions |  | Balance atEnd ofPeriod
|Year ended June 30, 2003                |  |                              |  |                             |  |                            |   |  |            |  |                       
|Deferred income tax valuation allowance |  | 358                          |  | 494                         |  | 2                          |   |  |           |  | 854                   
|Year ended June 30, 2004                |  |                              |  |                             |  |                            |   |  |            |  |                       
|Deferred income tax valuation allowance |  | 854                          |  | 1,808                       |  | 632                        |   |  |           |  | 3,294                 
|Year ended June 30, 2005                |  |                              |  |                             |  |                            |   |  |            |  |                       
|Deferred income tax valuation allowance |  | 3,294                        |  | 3,847                       |  | 602                        |   |  |           |  | 7,743                 
|Year ended June 30, 2006                |  |                              |  |                             |  |                            |   |  |            |  |                       
|Deferred income tax valuation allowance |  | 7,743                        |  | 6,923                       |  | 2,132                      |   |  |           |  | 16,798                
|Year ended June 30, 2007                |  |                              |  |                             |  |                            |   |  |            |  |                       
|Deferred income tax valuation allowance |  | 16,798                       |  | 8,973                       |  | (441                       | ) |  |           |  | 25,330                
|Period from inception to June 30, 2007  |  |                              |  |                             |  |                            |   |  |            |  |                       
|Deferred income tax valuation allowance |  |                             |  | 20,479                      |  | 4,851                      |   |  |           |  | 25,330                

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|(1) | Recognized through equity as a result of share issue costs.
|--- | -----------------------------------------------------------



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##### Table of Contents

EXHIBITS



|    |  |                                                                                                                                                    
|--- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------
|    | 
|1.2 |  | Constitution as amended by shareholders on November 5, 2007                                                                                        
|    | 
|4.9 |  | Put and Call Option to Lease between GE Real Estate Investments Australia Pty Limited, Goodman Property Services (Aust) Pty Limited and the Company
|    | 
|11. |  | Code of Conduct                                                                                                                                    
|    | 
|12. |  | Certification required by Rule 13a-14(a)                                                                                                           
|    | 
|13. |  | Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                             
|    | 
|15. |  | Consent of PricewaterhouseCoopers