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| AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         | 1.  CONTRACT ID CODE | PAGE OF PAGES |
| 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          | 2 |
| 2.  AMENDMENT/MODIFICATION NO.0018                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         | 3.  EFFECTIVE DATESee Block 16C | 4.  REQUISITION/PURCHASE REQ. NO. | 5.  PROJECT NO. (If applicable) |
| 6.  ISSUED BY CODE                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         | ASPR-BARDA | 7.  ADMINISTERED BY (If other than Item 6)CODE | ASPR-BARDA |
| ASPR-BARDA200 Independence Ave., S.W.Room 640-GWashington DC  20201                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        | ASPR-BARDA200 Independence Ave., S.W.Room 638-GWashington DC  20201 |
| 8.  NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               | (X) | 9A.  AMENDMENT OF SOLICITATION NO. |
| ACHAOGEN, INC. 1361331ACHAOGEN, INC.            7000 SHORELINE7000 SHORELINE CT STE 371SOUTH SAN FRANCISCO CA  940801957                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |   |
| 9B.  DATED (SEE ITEM 11)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| X                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          | 10A.  MODIFICATION OF CONTRACT/ORDER NO.HHSO100201000046C |
| CODE 1361331                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               | FACILITY CODE | 10B.  DATED (SEE ITEM 13)09/01/2010 |
| 11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 |
| o                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          | The above numbered solicitation is amended as set forth in Item 14.  The hour and date specified for receipt of Offers | o is extended | o is not extended |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       | Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:  (a) By completingItems 8 and 15, and returning _______________ copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) Byseparate letter or telegram which includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED ATTHE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER.  If byvirtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makesreference to the solicitation and this amendment, and is received prior to the opening hour and date specified. |
| 12.  ACCOUNTING AND APPROPRIATION DATA (If required)See Schedule                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| 13.  THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS.  IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
| CHECK ONE                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  | A.THIS CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A. |
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|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       | B.THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date. etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b). |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       | C.THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF: |
| X                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          | D.OTHER (Specify type of modification and authority)Bilateral:  Mutual Agreement of the Parties. |
| E.  IMPORTANT:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             | Contractor | o is not | x is required to sign this document and return      1      copies to the issuing office. |
| 14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)Tax ID Number:  68-0533693DUNS Number:  167293153A.The purpose of this no cost modification is to incorporate the following changes into the contract:1.The Period of Performance for the Base Period/ CLIN 0001 of contract HHSO100201000046C is hereby changed from 19 September 2010 through 31 December 2014 to 19 September 2010 through 30 September 2015, at no additional cost to the Government.2.The Period of Performance for Option 1/ CLIN 0002 of contract HHSO100201000046C is hereby changed from 21 September 2010 to 31 December 2014 to 21 September 2010 to 30 JuneContinued... |
| Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| 15A.  NAME AND TITLE OF SIGNER (Type or print)Derek Bertocci, Chief Financial Officer                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      | 16A.  NAME AND TITLE OF CONTRACTING OFFICER (Type or print)THOMAS P. HASTINGS |
| 15B.  CONTRACTOR/OFFEROR/s/ Derek Bertocci                          (Signature of person authorized to sign)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             | 15C.  DATE SIGNED12/17/2014 | 16B.  UNITED STATES OF AMERICA /s/ Thomas P. Hastings                     (Signature of Contracting Officer) | 16C.  DATE SIGNED12/17/2014 |
| NSN 7540-01-152-8070Previous edition unusable                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |   | STANDARD FORM 30 (REV. 10-83)Prescribed by GSAFAR (48 CFR) 53.243 |

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| CONTINUATION SHEET                                  | REFERENCE NO. OF DOCUMENT BEING CONTINUEDHHSO100201000046C/0018 | PAGE      OF |
| 2                                                   | 2 |
| NAME OF OFFEROR OR CONTRACTORACHAOGEN, INC. 1361331 |
| ITEM NO.(A)                                         | SUPPLIES/SERVICES(B) | QUANTITY(C) | UNIT(D) | UNIT PRICE(E) | AMOUNT(F) |

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| 3. | Under Article G.3. Key Personnel, Ian Friedland, CMO, Achaogen replaces Kenneth Hillan, CEO, Achaogen in the role of Principal Investigator. |

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| 4. | This is a no cost modification.  The total amount and all other terms and conditions of contract number HHSO100201000046C remain unchanged. |