Exhibit 21.1

|   Name of Entity                                              |   | Location ofIncorporation      orOrganization |
|-------------------------------------------------------------------------|--------|----------------------------------------------|
| Acadian      Physician Practices, LLC                                   |   | Delaware                                     |
| America      Management Companies, LLC                                  |   | Delaware                                     |
| AMG      — Crockett, LLC                                          |   | Delaware                                     |
| AMG      — Hilcrest, LLC                                          |   | Delaware                                     |
| AMG      — Hillside, LLC                                          |   | Delaware                                     |
| AMG      — Livingston, LLC                                        |   | Delaware                                     |
| AMG      — Logan, LLC                                             |   | Delaware                                     |
| AMG      — Southern Tennessee, LLC                                |   | Delaware                                     |
| AMG      — Trinity, LLC                                           |   | Delaware                                     |
| Andalusia      Physician Practices, LLC                                 |   | Delaware                                     |
| Ashland      Physician Services, LLC                                    |   | Delaware                                     |
| Ashley      Valley Medical Center, LLC                                  |   | Delaware                                     |
| Ashley      Valley Physician Practice, LLC                              |   | Delaware                                     |
| Athens      Physicians Practice, LLC                                    |   | Delaware                                     |
| Athens      Regional Medical Center, LLC                                |   | Delaware                                     |
| Barrow      Medical Center, LLC                                         |   | Delaware                                     |
| Bartow      General Partner, LLC                                        |   | Delaware                                     |
| Bartow      Healthcare System, Ltd.                                     |   | Florida                                      |
| Bartow      Memorial Limited Partner, LLC                               |   | Delaware                                     |
| Bolivar      Physician Practices, LLC                                   |   | Delaware                                     |
| Bourbon      Community Hospital, LLC                                    |   | Delaware                                     |
| Bourbon      Physician Practice, LLC                                    |   | Delaware                                     |
| Brim      Hospitals, Inc.                                               |   | Oregon                                       |
| Buffalo      Trace Radiation Oncology Associates, LLC                   |   | Kentucky                                     |
| Bullitt      County Hospital, LLC                                       |   | Delaware                                     |
| Care      Health Company, Inc.                                          |   | Washington                                   |
| Castleview      Hospital, LLC                                           |   | Delaware                                     |
| Castleview      Medical, LLC                                            |   | Delaware                                     |
| Castleview      Physician Practice, LLC                                 |   | Delaware                                     |
| Clinch      Professional Physician Services, LLC                        |   | Delaware                                     |
| Clinch      Valley Endocrinology, LLC                                   |   | Virginia                                     |
| Clinch      Valley Medical Center, Inc.                                 |   | Virginia                                     |
| Clinch      Valley Pulmonology, LLC                                     |   | Virginia                                     |
| Clinch      Valley Urology, LLC                                         |   | Virginia                                     |
| Colorado      Plains Physician Practices, LLC                           |   | Delaware                                     |
| Community-Based      Services, LLC                                      |   | Delaware                                     |
| Community      Hospital of Andalusia, Inc.                              |   | Alabama                                      |
| Community      Medical, LLC                                             |   | Delaware                                     |
| Crockett      Hospital, LLC                                             |   | Delaware                                     |
| Crockett      PHO, LLC                                                  |   | Delaware                                     |
| Danville      Diagnostic Imaging Center, LLC                            |   | Delaware                                     |
| Danville      Physician Practices, LLC                                  |   | Delaware                                     |
| Danville      Regional Medical Center, LLC                              |   | Delaware                                     |
| Danville      Regional Medical Center School of Health Professions, LLC |   | Delaware                                     |
| Dodge      City Healthcare Group, LLC                                   |   | Kansas                                       |
| Dodge      City Healthcare Partner, Inc.                                |   | Kansas                                       |
| Eunice      Community Medical Center, LLC                               |   | Delaware                                     |
| Georgetown      Community Hospital, LLC                                 |   | Delaware                                     |
| Georgetown      Rehabilitation, LLC                                     |   | Delaware                                     |
| Guyan      Valley Hospital, LLC                                         |   | Delaware                                     |
| Halstead Hospital, LLC                                                  |   | Delaware                                     |

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|   Name of Entity |   | Location ofIncorporation      orOrganization |
|----------------------------|--------|----------------------------------------------|

| Havasu      Regional Medical Center, LLC                           |   | Delaware  |
|--------------------------------------------------------------------|--------|-----------|
| HCK      Logan Memorial, LLC                                       |   | Delaware  |
| HDP      Andalusia, LLC                                            |   | Delaware  |
| HDP      Georgetown, LLC                                           |   | Delaware  |
| Hillside      Hospital, LLC                                        |   | Delaware  |
| Historic      LifePoint Hospitals, Inc.                            |   | Delaware  |
| HRMC,      LLC                                                     |   | Delaware  |
| HST      Physician Practice, LLC                                   |   | Delaware  |
| HTI      Georgetown, LLC                                           |   | Delaware  |
| HTI      PineLake, LLC                                             |   | Delaware  |
| Hurricane      Healthcare Partner, LLC                             |   | Delaware  |
| Integrated      Physician Services, LLC                            |   | Delaware  |
| Kansas      Healthcare Management Company, Inc.                    |   | Kansas    |
| Kansas      Healthcare Management Services, LLC                    |   | Kansas    |
| Kentucky      Hospital, LLC                                        |   | Delaware  |
| Kentucky      Medserv, LLC                                         |   | Delaware  |
| Kentucky      MSO, LLC                                             |   | Delaware  |
| Kentucky      Physician Services, Inc.                             |   | Kentucky  |
| Lake      Cumberland Cardiology Associates, LLC                    |   | Delaware  |
| Lake      Cumberland Physician Practices, LLC                      |   | Delaware  |
| Lake      Cumberland Regional Hospital, LLC                        |   | Delaware  |
| Lake      Cumberland Regional Physician Hospital Organization, LLC |   | Delaware  |
| Lake      Cumberland Surgery Center, LP                            |   | Delaware  |
| Lakeland      Community Hospital, LLC                              |   | Delaware  |
| Lakeland      Physician Practices, LLC                             |   | Delaware  |
| Lamar      Surgery Center, LP                                      |   | Delaware  |
| Lander      Valley Ambulatory Surgery Center, LLC                  |   | Delaware  |
| Lander      Valley Medical Center, LLC                             |   | Delaware  |
| Lander      Valley Physician Practices, LLC                        |   | Delaware  |
| Las      Cruces Physician Practices, LLC                           |   | Delaware  |
| LCMC      MRI, LLC                                                 |   | Delaware  |
| LCMC      PET, LLC                                                 |   | Delaware  |
| LHSC,      LLC                                                     |   | Delaware  |
| LifePoint      Acquisition Corp.                                   |   | Delaware  |
| LifePoint      Asset Management Company, Inc.                      |   | Delaware  |
| LifePoint      Billing Services, LLC                               |   | Delaware  |
| LifePoint      Corporate Services, General Partnership             |   | Delaware  |
| LifePoint      CSGP, LLC                                           |   | Delaware  |
| LifePoint      CSLP, LLC                                           |   | Delaware  |
| LifePoint      Holdings 2, LLC                                     |   | Delaware  |
| LifePoint      Holdings 3, Inc.                                    |   | Delaware  |
| LifePoint      Hospitals Holdings, Inc.                            |   | Delaware  |
| LifePoint      Medical Group — Hillside, Inc.                |   | Tennessee |
| LifePoint      of GAGP, LLC                                        |   | Delaware  |
| LifePoint      of Georgia, Limited Partnership                     |   | Delaware  |
| LifePoint      of Kentucky, LLC                                    |   | Delaware  |
| LifePoint      of Lake Cumberland, LLC                             |   | Delaware  |
| LifePoint      RC, Inc.                                            |   | Delaware  |
| LifePoint      VA Holdings, Inc.                                   |   | Delaware  |
| LifePoint      WV Holdings, Inc.                                   |   | Delaware  |
| Livingston      Regional Hospital, LLC                             |   | Delaware  |
| Logan      General Hospital, LLC                                   |   | Delaware  |
| Logan      Healthcare Partner, LLC                                 |   | Delaware  |
| Logan      Medical, LLC                                            |   | Delaware  |

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|   Name of Entity |   | Location ofIncorporation      orOrganization |
|----------------------------|--------|----------------------------------------------|

| Logan      Memorial Hospital, LLC                                                             |   | Delaware            |
|-----------------------------------------------------------------------------------------------|--------|---------------------|
| Logan      Physician Practice, LLC                                                            |   | Delaware            |
| Los Alamos Physician Practices, LLC                                                           |   | Delaware            |
| Martinsville      Physician Practices, LLC                                                    |   | Delaware            |
| Meadowview      Physician Practice, LLC                                                       |   | Delaware            |
| Meadowview      Regional Medical Center, LLC                                                  |   | Delaware            |
| Meadowview      Rights, LLC                                                                   |   | Delaware            |
| Memorial      Hospital of Martinsville & Henry County Ambulatory      Surgery Center, LLC |   | Virginia            |
| Mexia      Principal Healthcare Limited Partnership                                           |   | Texas               |
| Mexia-Principal,      Inc.                                                                    |   | Texas               |
| Minden      Physician Practices, LLC                                                          |   | Delaware            |
| Northeastern      Nevada Physician Practices, LLC                                             |   | Delaware            |
| Northwest      Medical Center-Winfield, LLC                                                   |   | Delaware            |
| NWMC-Winfield      Physician Practices, LLC                                                   |   | Delaware            |
| Opelousas      Imaging Center Partner, LLC                                                    |   | Delaware            |
| Opelousas      PET/CT Imaging Center, LLC                                                     |   | Delaware            |
| Orthopedics      of Southwest Virginia, LLC                                                   |   | Virginia            |
| Outpatient      Services, Inc.                                                                |   | Louisiana           |
| Palestine-Principal      G.P., Inc.                                                           |   | Texas               |
| Palestine      Principal Healthcare Limited Partnership                                       |   | Texas               |
| PHC-Ashland,      L.P.                                                                        |   | Pennsylvania        |
| PHC-Aviation,      Inc.                                                                       |   | Tennessee           |
| PHC-Belle      Glade, Inc.                                                                    |   | Florida             |
| PHC-Charlestown,      L.P.                                                                    |   | Indiana             |
| PHC-Cleveland,      Inc.                                                                      |   | Mississippi         |
| PHC-Doctors’      Hospital, Inc.                                                        |   | Louisiana           |
| PHC-Elko,      Inc.                                                                           |   | Nevada              |
| PHC-Eunice,      Inc.                                                                         |   | Louisiana           |
| PHC-Fort      Mohave, Inc.                                                                    |   | Arizona             |
| PHC-Fort      Morgan, Inc.                                                                    |   | Colorado            |
| PHC      Hospitals, LLC                                                                       |   | Delaware            |
| PHC-Indiana,      Inc.                                                                        |   | Indiana             |
| PHC-Knox,      Inc.                                                                           |   | Nevada              |
| PHC-Lake      Havasu, Inc.                                                                    |   | Arizona             |
| PHC-Lakewood,      Inc.                                                                       |   | Louisiana           |
| PHC-Las      Cruces, Inc.                                                                     |   | New      Mexico     |
| PHC-Los      Alamos, Inc.                                                                     |   | New      Mexico     |
| PHC-Louisiana,      Inc.                                                                      |   | Louisiana           |
| PHC-Martinsville,      Inc.                                                                   |   | Virginia            |
| PHC-Minden      G.P., Inc.                                                                    |   | Louisiana           |
| PHC-Minden,      L.P.                                                                         |   | Louisiana           |
| PHC-Morgan      City, L.P.                                                                    |   | Louisiana           |
| PHC-Morgan      Lake, Inc.                                                                    |   | Louisiana           |
| PHC-Opelousas,      L.P.                                                                      |   | Louisiana           |
| PHC-Palestine,      Inc.                                                                      |   | Nevada              |
| PHC-Selma,      LLC                                                                           |   | Delaware            |
| PHC-Tennessee,      Inc.                                                                      |   | Tennessee           |
| PineLake      Physician Practice, LLC                                                         |   | Delaware            |
| PineLake      Regional Hospital, LLC                                                          |   | Delaware            |
| Point      of Life Indemnity, Ltd.                                                            |   | Cayman      Islands |
| Poitras      Practice, LLC                                                                    |   | Delaware            |
| PRHC-Alabama,      LLC                                                                        |   | Delaware            |
| PRHC-Ennis      G.P., Inc.                                                                    |   | Texas               |

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|   Name of Entity |   | Location ofIncorporation      orOrganization |
|----------------------------|--------|----------------------------------------------|

| PRHC-Ennis,      L.P.                                     |   | Texas              |
|-----------------------------------------------------------|--------|--------------------|
| Principal      Hospital Company of Nevada, Inc.           |   | Nevada             |
| Principal      Knox, L.L.C.                               |   | Delaware           |
| Principal      Knox, L.P.                                 |   | Delaware           |
| Principal-Needles,      Inc.                              |   | Tennessee          |
| Province Healthcare Company                               |   | Delaware           |
| Putnam      Ambulatory Surgery Center, LLC                |   | Delaware           |
| Putnam      Community Medical Center, LLC                 |   | Delaware           |
| Putnam      Physician Practices, LLC                      |   | Delaware           |
| R.      Kendall Brown Practice, LLC                       |   | Delaware           |
| Raleigh      General Hospital, LLC                        |   | West      Virginia |
| River      Parishes Holdings, LLC                         |   | Delaware           |
| River      Parishes Hospital, LLC                         |   | Delaware           |
| River      Parishes Partner, LLC                          |   | Delaware           |
| River      Parishes Physician Practices, LLC              |   | Delaware           |
| Riverton      Ambulatory Surgery Center, LLC              |   | Delaware           |
| Riverton      Memorial Hospital, LLC                      |   | Delaware           |
| Riverton      Oncology Practice, LLC                      |   | Delaware           |
| Riverton      Physician Practices, LLC                    |   | Delaware           |
| Riverview      Medical Center, LLC                        |   | Delaware           |
| Rockdale      Hospital, LLC                               |   | Delaware           |
| Rockdale      Physician Practices, LLC                    |   | Delaware           |
| Russellville      Hospital, LLC                           |   | Delaware           |
| Russellville      Physician Practices, LLC                |   | Delaware           |
| Select      Healthcare, LLC                               |   | Delaware           |
| Selma      Diagnostic Imaging, LLC                        |   | Delaware           |
| Siletchnik      Practice, LLC                             |   | Delaware           |
| Smith      County Memorial Hospital, LLC                  |   | Delaware           |
| Somerset      Surgery Partner, LLC                        |   | Delaware           |
| Southern      Tennessee EMS, LLC                          |   | Delaware           |
| Southern      Tennessee Medical Center, LLC               |   | Delaware           |
| Southern      Tennessee PHO, LLC                          |   | Delaware           |
| Spring      View Hospital, LLC                            |   | Delaware           |
| Spring      View Physician Practices, LLC                 |   | Delaware           |
| Springhill      Medical Center, LLC                       |   | Delaware           |
| Starke      Physician Practices, LLC                      |   | Delaware           |
| Texas      Specialty Physicians                           |   | Texas              |
| The      LifePoint Community Foundation                   |   | Delaware           |
| The      MRI Center of Northwest Alabama, LLC             |   | Delaware           |
| THM      Physician Practice, LLC                          |   | Delaware           |
| Valley      View Physician Practices, LLC                 |   | Delaware           |
| Vaughan      Physician Practices, LLC                     |   | Delaware           |
| Vaughan      Regional Medical Center, LLC                 |   | Delaware           |
| Ville      Platte Medical Center, LLC                     |   | Delaware           |
| Ville      Platte Physician Practices, LLC                |   | Delaware           |
| West      Virginia Management Services Organization, Inc. |   | West      Virginia |
| Western      Plains Physician Practices, LLC              |   | Delaware           |
| Western      Plains Regional Hospital, LLC                |   | Delaware           |
| Woodford      Hospital, LLC                               |   | Delaware           |
| Wyoming      Holdings, LLC                                |   | Delaware           |
| Wythe      County Community Hospital, LLC                 |   | Delaware           |
| Wythe      County Physician Practices, LLC                |   | Delaware           |
| Zone,      Incorporated                                   |   | West      Virginia |

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