### UNITED S TATES ENVIRONMENTAL**PROTECTIO~** 

### AGENCY WASHINGTON DC . 20460 C " FICE OfCHEMtCAl. SAF ETY ,A/4D POU UTK>N PREVENTION 

### PC Code : 099050 01 ' Barcode: 0390070 M EMO RAN DUM DA TE: J uly 2 1, 20 11 S UBJECT: Ti er I Drinking Water Expo sure A sses sment f or the Secti on - , New Us e of Acetamiprid o n Soybean s to C ontr ol a Variety o fl nsect Pe st s T O : M ichael Doh eny , Chemi st C hristina Swartz, Branch Chief Ri sk A sses sment Branch 2 Health E ff ects Divis ion ( HED)

FROM: Jenni fer U rbanski, Ri sk Manager Re viewer Venu s E ag l e, Prod uct Manage r Regi stration Division (7505P ) Katrina White , Ph .D. Bio logi st

# v'or~~ L., \:..k 

# ?! .;J6/ ' c, \ Environmental Risk Bra nch IV Environmenta l Fate and Effects Divi sion ( 7507P) REVIEWED rv " BY : C hery l Sutto n, Ph.D. , E nvironme nta l Scie nti s t 

## t . '" '-v Environme nta l Ris k B ranch I V Environmenta l Fate and Effects D ivi sio n ( 7507P) APP ROVE D BY: Marietta Echeverria, B ranch Chief 

# fM . Envir onmental Ri sk Branch IV \ Environmental Fate and Effect s Divi sion ( 7507P) 

### E xecutive S umma ry Thi s mem o s umm arizes the Tier I estimated drinking water c oncentra tions · E DWC ) of ac etamiprid ( PC C ode 0 99050, ( E) -N l

- [(6-chloro-3-pyridyl)methylj-N2-cy mo- Nl

meth yla cetamid i ne) in s urf ace water and in ground water in s upport of the I

- r o po s ed Se ction 3 n ew us e of ac etamiprid fo r control o f chewing , s ucking, and pierci ng i nsect s on s oybeans . 

## 28

### N ippon Soda C o 

## LT r >i s s eeking reg is tratio n f or a liquid f ormula ti on ( Ju stic e® I nsec ti cide , E PA R eg i s tration N umbe r S0 33- XXX I ) 

### th at c ontain s 1 3 % ac etamiprid and 10% bi fenthrin a nd the technica l fo rmulatior ( A c e tami p rid T echnical ; E PA Re gi s tr ation N umber 8033·2 0) tha t c ontain s 99 . 5 % acetam iprid . T h i s as sess ment f o cuse s o nly o n th e ac t i ve in gr edient ac etamiprid ; b ifen thrin i s n o t as ses s ed . G roun d , a e ri al, an d c hem igatio n ap plicati o n s are p r opos ed . Th i s ass ess ment c ons ide r ed a m axi mum s eas onal rat e o f 0 .0 8 I b s a .i .lA f or the p ro pos ed new u s e o n so ybean s . The E DWCs f o r bo d 1 

### s urf a ce an d gro und w ater re c ommended f or u se i n H ED 's h uman h ealth d ietary ri sk assess m et t are s ummarized i n 

### T ab l e 1 . Th e E DWCs res ult i n g fr om th e p roposed a pplica tion rate ar e l ove r than th e E DWC s fo r surfa ce an d g round wa te r in the p revi ous dri nk ing wat er ass essments f a " ac e t am i p ri d ( D364248) . P re vious d rinking w ate r ass essm e nts used i np u t va lues b ased o n vari ous ki netic mod el s and truncated d ata s ets . Th e degrad a ti on kin etic s f or thi s ass ess m e nt we re rec t..c ula ted us ing all data an d the s i ngle fi r st -o rder m ode l. 

### Kir n

etics w ere also e s tim ated ass uming t - e t 

### un extracted re sidue s we re the par ent c ompou nd f o r so m e s tudi es. Theref o re , E DWCs '" e re e stim ated us ing the n ew i nput p aramete rs and th e pr e v iously e va l uated u s e s c e n arios . A ddit i o n a ll y, a pe rcent c ro p pe d are a w as n ot ap plied t o th e m od eled v alu es beca u se ac etamip rid i s regis tered f or us e i n res ident ia l areas , d om e s tic d wellin g s , rig hts of w ay , an d o n o rnam ent als . vla ny o f the se us e p a nern s h a ve n ot bee n pre vi o usl y asse ss ed and it i s n ot known i f thi s ri sk a s -c ssme nt evalua ted the hi g he st u se rates o n all a cetami prid l ab els; howev er , th e re pon ed val u es a - e the hi ghest v alues b ased o n pr evi ous ly evaluate d u s e s. Th e re s ult ing E DWC s are v e ry si mil ar t o t he max imum co ncentrati o n s pre v i ou s l y e s tim ated? No m o nit o rin g d ata ere c urrent ly a vai l able to furt h er ch ar ac terize p otential drinking wa ter expo s ure .

I Th e s e ar e th e h ighest L ) WCs fo r t he pr oposed an d pr eviously eva luated use s ce n a no s. .. S ource o r D r in k in g \\' II ter Acet amip rid c o n cent r ation i n dr in king water ( u g/L) S ur face wa t er drinki n g v are r s ourc es acute : 24 . 7 0 c hronic: 7 . 09



## . Groundwater drink ing " . ate r so urces 0 .004

. . 

### Tabl e I. 

### T ier I E D \VC s for drinking wa ter r isk a sses smen t ba sed on ac etamiprid use o n cit rus a nd t ree nu ts 1



### Pro posed U s e N ippon S oda Co. L 1 D i s se eki n g regi s tr ation f o r a Secti o n 3 n ew u s e of acetami prid ( PC Code 0990 50) o n so ybean s f or c ontrol of c he win g, su cking , and pi e rc ing i n sec t s . Th e n ew use s e v aluated in thi s assess me nt ar e f or th e li qui d en d

- use p roduct , Ju stic e® I n se c ti cide ( E PA

I Th e p r oposed reg istrations will not g et a full re gistrat ion nu mbe r u ntil th e product is registered . The XXX reflec ts the numbers th at w ill be complete d wi th re gistration . 2 Previo u sly e st imated ac ut e an d annual av era ge surface w ater c oncentrat ion s were 20 . 1 and 4 .9 pp b , respectively . Previ ously e stimated gro c ndw e t e r conc entration s w ere 1.6 parts per tri llion. 

## 28

### re gis tration N um ber 8 033 -XXX l , 

### 13 % a ce tamiprid and 10 % bifenthrin ) an , A cetamiprid T echnic a l (E PA Re gi stration N umber 8033-2 0, 99 . 5 % a cetamiprid) . Us es i -i v o l vin g aerial , c he mig ation , gro und , and a irb las t applic ation s o nto soy bean s are propo sed . Thi s ass ess ment f oc use s o nly o n the ac tive ingred ient a c etamiprid ; b ifenthrin i s n ot a ssess ed The table o n pa ge I 0 of th e label f o r Ju s tic e® In secticide i ndicate s th at 0.0 14 -0 .07 I bs a . i . ' A m ay be applied with a s in g le a ppl ica tion ; h owe ve r , the table d oe s n ot s pe cify wheth er t he r e- t e i s f or bifenthrin o r a ce tam iprid . Bas ed o n the m aximum ounce s o f product th at may be 

### applie c, th e max imum s ing le app lication ra te i s 0 . 04 I b s a cetam i prid per a c re with a maximum o f tw o a pplicat io ns a llowed per s eason and a mi nimum a pplicat ion in terval of s even d ay s. Th e m ax imum s easo n al applica tion r ate s pecified o n the la bel i s 0 .0 78 I bs acetam iprid per a c r e p er ! ro wing se ason . The maximum s ingle a pp li catio n rate and m aximum number o f application s s ug j e s t a max imum s e as ona l app licati on ra te ( 0 .04 x 

### 2 = 

### 0 . 08 I b s acetamipridJac re) th at i s h igh c r 

### t han th e m a xim um s ea s o n a l r ate o n the l abel ( 0 . 78 Ibs a cet amipri d/acre) . Ti er I 

### mod eling d oe s 1 10 t a llow multi ple s ing le a pplication ra te s as an i n put and b ased o n th e m axi mum n umb er of ap p licat io n s a nd si ngle ra te 0 .08 lb s acetam iprid/acre may be ap plied ; the refore, the calc ulated 0 .08 lb a.i .lA rate wa s as sumed for mod e ling . The lab el s h ou l d clarify the m ax im um applicati on ra te s fo r bife nthrin and acetam iprid . 

### E nvironmental Fate and Trans port Summary Ac etamiprid i s cl ass ified as moderatel y m obil e u sin g the F AO cl as sifi cat io r s ys tem (Koc s = 

### 15 7 -2 98 Uk g OC ) . The prim ary route of de gradati on i s aer obic s o il me talx 

### .l i s m . U ne xtrac t e d re s idue s mad e up a s ign i fi c ant am ount o f rad ioa ctivit y and the identi ty of th e re sidue s is unknown in metabol i sm s tu d ies. Therefore , degradation rat es were e stim ated f or the parent alo ne and as s uming th at un e xtra cted re s idu e s were th e par ent. Aerobi c s oi l m etaboli s m rate s for the parent r anged from < I d ay t o s i x da y s for th e pare nt and tw o to 9 9 da y s f o r the parent and unex tracted re sidue s in ni ne s oils 

### ( Append i x A ) . A ero bic aquat i c 

### me tabol i-m rate s we re s lower a t 2 5 day s for the parent on ly and 7 4 da ys for parent and u next racted re sid u e s in one s ed im ent ( MRID 44988513 ) . Anaerobic aquati c metaboli sm w as mu ch s lowe r and 

### tl- e h a lf-life was 32 5 day s in a l oamy s and s ediment (M RID 4 4988 5 1 2 ) . Acetaminp rid i s s table 1 0 

### h ydroly s is a t 25 ° C and a queous ph ot ol y s i s i s no t a n i mportant deg radation p athway ( half-life = 

### 3 4 days) . A ce t am ip rid may be 

### tr an s ported t o s urface wa t e r a nd gro und wa ter v ia ru n off, le a chin g, a nd s pr a y drift . An 

### updated s ummary o f a ll envirorune nt al fa t e da ta i s avai lable in 

### Append ix A . Modeling Approach and Input 

### Parameters The Meta bo li sm A ss e ss ment Review Co mm ittee ( MA RC) reporte d that th e re s idue o f c oncern fo r a c etam iprid i s the paren t o nl y (U SEPA . 2 0 0 1) . Th e 2009 

### "T ier I Dri nk i n g Wat er A ssess m e nt fo r A ceta m iprid Pro pos ed U ses on R ed Clover ( G row nf o r S e ed On l y ) , G r a-i e a nd T omat o (G reen h ouse)" w as c ondu c ted for a cetamiprid o nly. Th eref or e, thi s as sess me nt will al s o be c o nduct ed on ac e tamiprid o nly . U nextract e d re s idue s w ere o b se rved in a erob i c s o il and a erobi c aqua tic metaboli s m s tud ies and i n so me s tudies i t w as un c ertain whether 

### the - un e xtracted re s idue s

1 Pr o po sed r egi stra tion s are not ass igne d a full reg i s tr at ion n umber. The XXX 's r epre s ent lumber s that w ill be d ete rmined i f t he prod uct i s regis tered . 

### 2 8

### we re p arent 

### co mpo u nd.' Th e ref ore. when it was u n certain . h alf -live s were e st ima ted ass uming th e un e x tra ct ed re s id u e s were the p are nt co m po und . W he n t he par ent w as s h ow n to de grade a t th e beg inning o f th e stu dy and un extracted re sidues d id n ot appear unt il the en d of the s tu dy. it v.

'3S as s umed that the 

### un extracted re s idue s we re n ot th e paren t co mpound . E DW Cs wer e gene rated u sin g EFED ' s s tand ard s uite o f m odels. T he FQ PA Index Re servoir S cre en ing T ool ( FIR S T v e r s ion 1.1 .1 . Mar ch 25 , 2008) i s a s ur fa ce w ater m od el that i s u sed t o e s timate bo th acut e an d c hron ic pe sticide c onc entr ation s in u ntreated dr inking wate r . EDW C s f rom FIRS T repre s e nt co nce ntra tio ns wh i ch might oc cu r fro m a s i ng le l-i n-l O -ye ar s torm eve nt fo ll owi ng th e las t ap p l ica t ion o f pe stic ide a t a loc ati on m or e v ulnerab le th an m o s t locat io ns in th e Uni ted S t a tes to r uno ff , reg ardl ess o f the crop be in g produ ced . The m od el co ns iders redu c t io n s i n d issol ve d conce ntra t ion du e to 

### the percent age of the w atershed w hich is c ropped ( pe rcent cro pped are a . P CA). d ue to so rptio n o f pe sticide t o fi eld soi l and to reservoi r bo nom se diment . due t o inc orpo r a tion o f th e pe s ti cide a t the time of ap plicat ion , d ue t o d egradation in so il be fore ru n off to the re s erv oir , an d du e t o de gra datio n of th e pe s ticide wi thin th e w ater body . Re servo ir wa ter c o n c entr at ion s m ay b e in cr eas ed du e to depositi on o f s p ray d rift int o t he feed ing s tream or di rectly 

### i nto th e re s ervoir it sel f . FIRST i s d es igned to m im ic a m ore co mple x s imulation u s ing th e li nke d P RZM3 ( C ar s el 

### e t a l., 19 97) and E XAMS 2 .9 7 .7 (B urns, 20 00 ) m odels, b ut requir e s les s tim e and e ffort to c o mpl e te . A m ore deta iled d escr iption of th e index re s erv oir wat er sh ed c an b e f o und i n U S EP A , 2 010 ( U SEPA, 1 998, 2 0 IO c) . Th e FI RST m o del and u s er s manu al s may b e d ownloaded f rom the U .S. E n vi ronme nt a l Protection A genc y (E PA) W ate r Mod e l s we b- pag e (h n p :/l w v. w .e pa.Q o v/o p pefed l z m odel s/wa ter / s f i r s n . Per c ent Cro p ped Ar eas ( PCA) th at a c c ount fo r th e maximum area with i n a w atershed th at m ay b e planted with th e m odeled c rop ar e ap p l ie d to co ncentration s pred icte d by F I RST ac co rdi ng to "Guida nce on Develo pm ent an d U s e of P ercen t C ropped Are a A djus tment Fa ctors in Drinking Wa ter Exposure Assess men ts" 

### (U SE PA, 2 010 b ) . Dri nkin g w a ter assess me nts ha ve b een c o mp le ted f o r use of a cetamiprid o n c lo ve r , gr ape s an d other cli m bi ng vi ne s , gree nhous e g rown to matoes , c itrus f ruit s , tree nu ts. bu lb vegetab les , s u cc ulen t legume s , s trawbe rries, o ther be rri es, and po ta to e s ( D3642 48, D3 3 159 6 . D 30 18 5 9, D 26 3 686, D 27 9762) . A ll of th e se crop s ar e agr ic ultural c rops; th erefore . a P CA o f 0 . 8 7 wa s u sed in th e p a st in e stimat ing s urfa c e w ater c o nce ntra t ions. O PPI N wa s s earc hed (July 1 ; 1 , 2 011 ) and th er e ar e c urrently re gis tered u s e s i n orname ntal s ( 803 3

- 22 , 

### 803 3-107), d omesti c d wellin gs ( 80 33- 26 , 8 0 3310 9) , ri ght s o f way s ( 80 3 3-96 ) , and re siden ti al ar eas ( W A 0600 11) . If a c hemical has u se s in a v ariety o f land co ver cl asses th a t includ e re s id e ntial are as, it i s c urr ent po li cy n o t t o u s e a PCA (U SEPA. 20 lO b) . Sc reening Co ncentration i n Grou nd Water ( SCI-G R OW v 2 .3, Jul. 29, 2003 ) i s a regr ession m odel use d as a sc re e ning tool to e stimate pe s tic i de co ncentrations fou nd in g round w ate r u s ed as drink in g w ate r. S C I -G ROW wa s d eveloped b y fi ttin g a lin ear m odel to gro und w ater c once ntrati ons with t h e Relat i ve I ndex of Le achin g Pot ential ( RlLP ) as t he i nd ependent v ariable. Th e RlLP i s a fun ction o f a e rob ic so i l m etaboli sm an d th e s o i l

- w at er part ition c oefficie nt . The o utput ofS CI -GRO \V repres ent s th e c o nce ntra tion s th at might be 

### e xpected i n s hallow un c onfin ed aqu ifer s u n de r 

### s a nd y s oil s, whi ch i s representative o f th e g round w at er mo st vu ln era ble to 

### pe st ici de c o nta m ina t io n a nd likel y t o s e rv e as a drinkin g wat er so urc e. Th e S C I

4 lf u nex tr acte d re si du es - o rm e d alo ng w ith l oss of the pare nt compo und it i s po ss i bl e that the u nex tracte d r e si du e s ar e th e par ent c ompo un d . however . i f the parent degra ded s ig n ificantly in the beg inn i n g of the st udy and unextract e d res i d u es d id not form u ntil the en d o f the s tu dy . the unextra c ted re sidues are unl ike ly to be th e pare nt compoun d . 

### 28

### GROW model and us er 's manual may al so be d ownloaded from the E PA W a ter Model s web

pa ge ( http : //wv''' \ v .ep a.go v/ op pefed llmod e lsJ w at er /# scigrow). P CAs ar e n o t u sed w ith the S CI

G ROW m odel. A s ummary of th e mod e l input parameter va lue s u sed in FIR ST i s pre se nte d in T able 2. A summary of th e model input param eter va lue s u sed i n S C I-GROW i s p re se nted in T a ble 3. Input parameter s we re s elected in accordance w ith E FED 's "G uid ance for 

### Se l e ct ing Input P

arameters in Modeling th e E nvironmental F ate and Tran sport of P estici des;" Ve rsion 

### 2 .1 (U SEPA ,2 009b) . Co effic ients of v a ri ation ( CV) we re lower for organi c -carbon no rmali zed s oli d wat er di stribution coefficient s (K 

### oc ; C V =2 8%) a s c ompared to s o l id

- wa ter d istr ibution coeffi c i e nt s (K! ;**CV 66%** **) ( ID**  

### 446 5 1884 ). Ther efore , th e m ean Koc (227 Llkg D C) wa s u sed to e stima t e a cetamiprid c oncentratio n s in s urface water in F IR ST and the median 

### K cc Llkg -OC) was u sed f or SC I-GROW. T he aerobic soil metabo li sm input va lue i n FIR ST W l ':S 

### c alculated as the 9 0 th 

### percenti l e upper c onfidence bound on the mean (7 da ys) of fiv e 

### h alf-life v a lu es and some of th e v alu es were e stima ted for t he par ent and un extracted r e sidue s (MRID s 4 4 6 5 18 7 9, 4 46518 8 1 , and 44699 101 ) . Th e ae rob ic s o il metaboli sm i nput v a l ue for S CI -G ROW w as 

### the median of the s ame fi ve half-lif e v alue s . A erobic s oi l metaboli sm v a lues from MRID s 4 4 65 1880 and 462 5560 3 w ere not u sed i n mode ling du e to the poor data q uality . The pro posed label allow s for gro und and aerial s pra y applic at ion s. Th ere fore , E DWC for broadc ast a eri a l a nd g round s pray a pplica tions were b oth e s timated in order to be repr e sentative of a ll appli ca ti on s cenario s. On e aer obic aquat i c m etaboli sm v a lu e w as avai lab le ( 7 4 da ys in a loam y sand; !\, r R ID 4 498851 3) th at wa s e s ti mated as su ming un e xtracted re sidue s w ere the parent compound . Th e v alue wa s multip lied b y thre e t o obtain the model input v alue of 222 day s fo r FIRS T. T h e a q ue ous p hotol ysi s ha lf -lif e i nput v a l ue i s adju sted f or c ont inuo u s illuminati o n as w e ll as f or la titude / s ea s on to re flect pho to ly s i s i n s ummer s u n l ight at 40 0 

### N l atitude . The FIR ST output fil e i s l ocate d in Append ix B. T he SC I-G ROW outpu t fie is l oc a ted i n A p pendi x 

### C. Table 2 FIRST ( vI I 0) I nput P ara meter V alue s for Acetamip rid u sc un Sov b ean s 

# . . . . Pa rameter Value S o ur ce C omment A pplication Rate (lb s Se e T ab le 4 Proposed Label See S e ction title d " Proposed Use " for a . i.lA ) l full ex planat ion . N umb er o f A pplicati o n s S e e T a ble 4 Propo se d Label Interva l betwee n 7 Proposed La b el A ooltcation s ( d ays) O rganic c a rbon Me an o f five K oc v al ue s. S ee te xt . part itio ning co e ffici ent 2 27 MR ID 446 5188 4 ( K oc ; m l./s OC) MRID s 46 5188 1 , I s the 9 0' p (; ; 'ce ntile upper c on fi dence Aero bic So i l bou nd o n the me an of fiv e v al ues, The M e taboli sm Ha l f

- lif e 7 4465 188 2, mean val ue was 4 d ays . S ome oft he (d ays) 4 469910 1 , va l ues w er e esti m ated for r esidue s of 4 46 5 1 8 7 9 p are nt an d un extrac te d re s idues . 

### 28Par ameter V alu e S ource C o mment Wett ed in ? No Propo sed labe l . None De pth of Incorporati on 0 Propo sed label. No ne ( inche s) Method of A nnlicat i on ero u n d a n d aeria l s n rav Pr ooosed labe l. None Pe rc ent C roppe d A r ea 1.0 P CA Gu idance The re are c urrently regi stere d ( Pe A) ( USEPA . 20 10b ) r esid ential an d r i sh ts -of

- wav use s .**So :~** **ity** in W ater 4 250 MRID44 65 18 11 M eas ured at 2 5 °C ( m o L ) A erob ic Aquatic M e asur ed v alue t imes three t o a c count M etaboli sm Ha lf-life 

### 222 MR ID4498851 3 f or u n certa inty as sociated with u sing a ( davs) si nate value . H ydrolysis Ha lf-lif e at Stable ( 0) MRID 446518 76 No ne 

## nin ( d

.,,) Aqu a tic P hotolysis 34 M RID 44988 509 Non e H a lf-lif e at pH 7 ( day s ) 

### T able 3. SC I-G ROW (" '2.3) Input Parameter Values for Acetamiprid Use on Soybeans Paramet er 

# I V a lue So u rce Co mments A pp licat ion Rate ( Ibs Se e T ab le 4 Propose d labe l S ee Sect ion t itled " P roposed Use " f or a.i .lac re) full ex plana t io n . Nu mber of Se e T able 4 Pr opo sed l abel aoclication s M edian o f five va lues . The re i s n ot a 

### K

"" (m U g) 25 1 MRI D 446 5 1884 three fold d iffere nc e i n obse rve d v alue s. See tex t . A ero b ic s o il MRID 46 23 5729 . Value i s th e me dia n of fi ve val ues . m etaboli sm t 'IS ( da ys) 

### 5 .6 4 79 258 0 1 . Som e val ue s w ere calc ulated a ssuming t hat un extracted r esidues w ere t he 479 11201 p ar ent com pound . 

### Modeling Results 

### Esti mated ace tamip r id co ncentrations in s ur f ace wa ter a nd g round w ater u sed f or dr inking w ater are s umm arized i n



### 2 8

### Table 4 . Us e sc enario s ev aluated in previ ou s drinki ng water ass es s ment s a n d the pr oposed us es were evaluat ed . A cute e stimated acetamiprid c oncentrati on s in s urf a c e wa t er u sed fo r drinking water ran ged from 3 .80 to 24 . 7 p g/L . E stimated annua l ave ra ge con centrat ion s range d from 1 . 07 to 7 .0 9 u g/ L . S imulated c o n cent ration s i n g rou nd w ater r an g ed from 0 .0 0 0 4 to 0 .004**gIL**



### 7

### T ab le 4 . Esti mated Conce ntrat ions of Ac etami prid i n S urface Water and Grou nd water U sed as a Drinking Water Source. B olded va lues are t he max imum va lues. Use S it e/ So urce Produc t Name 

### E IJ A Reg . No. S ingle Ap p. Rate (Ibs. a .i./A) Number of App s. S easonal App. Rat e (Ibs . a.i .lA) Interval Bet ween

App s. ( day s) App . M ethod Surface Water

,... .. un . 

# I C h ronic**JI~ L..**  (1l J,t

/ L.. )



### - '

----- 1

-- 1 Soyb ean! P roposed

L abe l S oybea n/ P ro posed

L a bel J ust ice In s ect i ci de Ju stice Insectic ide 80 33- XXX i 80 33- XXX i 0 .04 0. 04 2 

### 2 Prono sert 

# ' . !! het 0. 08 0 .08 7 

### 7 A er i al Gr o u nd 3. 95 3 . 80 1.14 1. 07 0. 000 4

P r e v ious Dri nkin g Wat er Asses s ment Us es wi th U p dat ed Modeling Number s C l

over ( for us e in !D , O R, and WA o nly )/ D 36 4 2 48 G rape s a nd o th er C limb ing V in e Sma ll

F ruits / 0364 2 48 G reen h ousegrow n To matoes ! 03 64248 C it rus fruit s ! 0364 248 T ree N uts/ 03 64248 A ssai l 70 WP A ssail 3 0 

### S O A ssa il 70 WP A ssail 30 

### S O Tri StaI'3 0 

### SO Assa il 7 0 W P A ssa il 30 

### SO A ssa il 7 0 W P Assai l 3 0 

### SO 80 33-23 80 33

- 36 80 33

- 23 80 33-36

8033

- 94 80 33-23 80 33-36 80 33-23 80 33-36 0 .075 0 .07 5

0. 1 0 . 1

0.07 5 0.25 0.25 0. 18 0.18 2 2

2 2 2 4 4 0 .0 75 0 .0 75

0 . 2 0 .2

0 . 15 0 .55* 0 .55* 0. 72 0 .72 N o n e None

1 4 14

3 a ss u med 7 7 1 4 1 4 A er i al Ae ri al A e r ial s A eria l C he m igatio n/ so il dre nch ing

Ae r i al Ae ria l A e r ial Ae rial 4 . 79 4 . 55 8.4 2 7 . 60

8 .2 3 24.7 0 22.7 8 1 7. 95 14.53 1.37 1.27 2 .43 2 . 12

2 .32 7 .09 6 .35 5. 2 9 4 .05 0 .0004

0.00 1

0 .000 8

0 .003

0.00 4



### 8Pot ato, T o bacco / 3 Aer ial 0 3 0 1 859 

### NS N S 0.07 5 4 0 . 3 a ss u med a ss umed 13 . 54 4 .0 0 0 .00 2 Dome stic Ou tdo or Use S ite s/ 0 3018 5 9 

### N S NS NS NS NS N S NS NO NO NO "" v'at,ons:**N~ " Ol** **C1** " "**Nu ~no{**  " """" " ,, ; pp - PI' 't . "On I Th e pr oposed regi stra tion s w ill not get a f ull r e gistration n umb er u nti l t h e pr o du ct i s re g i stered . T he XX X r efle c t s th e n umber s t hat w ill be c ompleted w ith r egistrat ion .



### 9

### M onit ori ng Data Th e f oll owin g d ata ba s es and so urces were searc hed fo r m onitoring i nfo rmation o n a c etam iprid :

• The U nited S tate s Enviro nmental P rotection A gency (US EPA) STO RET Database**(http \\** **\\ '\'.I** **t!** 

### dbtop .htm I ) 

### • T he U nited St ates Geo log ica l Survey ( USGS) National Water -Quality Assessme nt (NAWQA) P rog ram Da ta Ware house (h tt p: //infotre , k .er.usgs . gov/traverse/ f?p- NA WQA:HOME: 140551 720 6 (44 5 6 7 ) • Th e USGS Na tio n a l Stre am Quali ty Acc ounting N etwo rk (NASQAN) progr am ( h tt p ;/ / wa ter. :l s !.!s .g o v/n asga nl) N o monitori ng in f orm ation was fo und. 

### Drinking Water T rea tm ent T here i s n o a vai lable information o n th e drinking wa ter treatment ef fects o n a c et amiprid. T he EDWCs in thi s as se ss ment are re pre se ntative o f conce ntrations in drinki ng water so urce wa ter ( pre- trea tment) . F or su rf ace wa ter . th e co nce ptual mod el ass umes tha t a p esticide reache s surface wat er v ia sp ray drift o r s ur face run off a nd 

### it i s in stantaneously mi xed and co ncentrations are o bserve d in th e h a t er b ody . Acetamiprid is s table to h ydrolysi s. T her e fore, a cetamiprid wi ll n ot deg rade b y h yd rol y s is dur ing the time tha t e lapses fro m dri nking water in take th rough d istribution t o th e fi rst tap. P hotoly s is i s no t an im portant d egradation p athway. The refore, if u ltraviolet li ght we re used as a m ean s of di s i nfect ion, d egradati on of aceta miprid wou ld n ot b e e xpected to be s i gni f i cant. Acetami prid does degrade v ia ae robic m etabolism a nd so me m ay d egrade w ith aerobic dige stio n. T he m ost s ucce ssfu l drinki ng water trea tment proc es s f or r emoval o f pes ticide s f rom d rinkin g wa ter i s thoug ht t o b e tr eatm e nt with g ran u lar ac tivated carbon (GAC) w hic h is o nly u sed i n l arger dri nk ing w ater treatment fac ilitie s. Th e a bility of GA C to re move pes t ic ides w ill vary wi th the p ropertie s of the c hemical , the viabil ity of th e b iofilm o n th e GA L and whet her th e s o rption s it es on GAC h ave reac hed cap acity ( Badriyha e t 

### aI., 2 00 3; Z hao 

### e t a i .. 1 999 ) . Data o n th e sorp tion of acetami prid to GAC are n ot ava ilable . 

### Conclusions T h e es timated co nc entra t io ns prov ided in th is assessme nt we re g e nerated f ro m Tie r 1 m odels an d are c onservative est i mate s of acetami prid conce ntrations i n untreated d rink ing wa ter. The re were a n um ber of 

### urc erta i nties asso ciated wi th this d rinking water e xpo su re a ssessme nt. T he majo r un c erta inty i s w h et h e r th e hi ghest u se patte rn f or acetami prid was ev aluated. A nother a ssumption tha t w as f act o re d in to th e as s essment was th e a dditio n o f th e u nidentified, un extracted resid ue s int o t he c alcu lation of th e ae robic so il m etabolism h alf-li ves; h owever , thi s h ad littl e imp act on t h e fi n a l E DW C a s recalc ulated EDWC f rom prev iously reg i ste red u ses w ere s i mi lar t o t hose p re v iously es timated. Th ere i s a l so un certainty as socia ted wit h the mod eling wi th F IRST an d SC I · ,G ROW. T hey ar e b oth T ier I mode ls an d ther ef ore co ul d pote ntially overes timate th e c hemica l co ncentrations. 

### If d ietary ri sks r equire r efinement, high er t iered m odels

10

### and modeling sce nario s c an be utilized upon requ est . Finally , th e m aximum annual rate model ed fo r soy beans w as b ased o n the s tatements o n th e labe l indicating that tw o a j. plications o f fiv e o unces were a llowed (e.g ., 

### 0 .0 8 Ib s a L IA ) 

### and no t o n th e maxim um s e aso na l rate s tated o n the la bel ( 0.07 8 I bs a .i JA) . 

### Literature Cited AE RU . 2 009 . Th e FOO TPRINT Pe sticide Properties Datab ase . A gricultu re & 

### Environment Re search U n it ( AERU). A vai lable at htt p : / / si tem .h ert s .ac . uk /a erul tl , o tprintl (Acce ssed July 9 , 2 009) . B adriyha, 

### B. N. , Ravindran , V ., Den , W. , & 

### Pirbazari, M . 2003 . Bioad sor b er efficiency , de sign, and performance forecasti ng for alachlor removal. 

### Water R esearch. 3 7. Burn s , L. 

### A. 

### 200 0 . 

### Ex posure Analysis Modelin g S ystem ( EXAMS) : Use r M anual and System Do cumentation . R evision G . EP A/6001R-00 /81 -023 . Sept ember 2 0{ 1 0 . E cosystems Re search D ivision . Na tional Expo sure Re sear ch Laboratory . U nite '! Sta tes Environm ental Pr otec tion Agenc y . C ar se l, R . F . , I mhoff, J . 

# c ., Hummel , P , R ., C heplick , J . M ., & 

### D onigian Jr ., J . S . 1 9 9 7 . PR ZM -3. 

### A M od el

for Predicting Pesticid e an d Ni trogen F ate i n Crop R oot a t d U nsa turate d Soi l Zones : Users Man ual for Re lease 3 . O . 

### Memo randum From t o Env i ro nmen tal Re search Labo rato ry . Office of Re search an d D evelopment . U nited S tates E n vi ro nmenta l Protectio n Agenc y . U SE PA . 199 8 . 

### An I nd ex R e s e rvoir fo r U se in Ass essing D ri nking Water Exp o s ure . P roposed Me thodsfo r Basin - scale E s timation o f Pe s ticide Co n ce ntra t ions in F l owing 

### Water an d R es ervoir sfo r Tole ran c e R eassessm ent. J . - . P re s entation t o FI FRA S cie n ce Advi sory Panel , 1 9 9 8 . , . U S E PA . 2 001. 

### Ace ta miprid R es ults of th e H ED M etabolism A sse s sm ent R t vie w C ommittee . 0 278652 . M emorandum From H . Bietl ct , M . Doherty & 

### P . Hurl ey to Y . D onovan . Office o f Pre vention, Pe sticid es, an s Toxic S ubstances. U nited Sta tes E nvironmental Prote ction Ag ency . C FR . Part 2002 . 

### Ac etami prid P esticide Fa ct S heet . G overnment Printing 

## O f fi ce . Was h ington , D.C. U SEPA. 

### 2009 a. E stimation Pro gram Interf ace (E PI) Suite : United S tates E nvi ronmental Protection A genc y . Ava ilable at http :// v."\\ow .epa .gov/ o pp tl exp osurc .: pubs/cpi suite. htm ( Accessed Jul y 9 , 2 009). U S E PA . 2 009b . 

### G uidanc e for Select ing I n

put Parameters i n Mod eling the**on** 

### F ate a nd T ransport of Pest icid es , V ersion 2 . 1 . Environmental Fate and E f f ect s 

### Div ision . O ffice o f P e sti cide Pro grams . U nited Sta tes Enviro nme ntal Pr otecti on Age ncy . A vailable a t h ttp:// v.ww . e pa. g ov /oppe fed l /mod el s/wate r /i nput p aramet erg u :. :l a nce.ht m ( A cc e sse d N ove mbe r 12 , 2010). U SE PA. 2 0 1O a. 

## Guidan ce fo r R eporting on the Envi ronm en tal F ate and T ranspo rt o f t he S tressors o f Conce rn in the Problem Formula tion for R egist ration Kevi e w, R egistratio n Review R isk A ssess m e nts, L isted Sp ecies L itigation A ssessments . New C hemica l R isk Assess ments, a nd O th e r R elevant Ri s k As sess ments . Janu ary 2 5, 2 0 I 

### D . E nvironmental Fate and E ffects D ivi sio n , .

II

### U SEPA. 2 0 1 O b . 

### Gu idance o n Developm ent and Us e o f Percent C ropped Area Ad ju stment Fa ctors in D r in king Wa ter Ex posure A ssessments. E nvironmental Fate and E ffec ts D ivi s ion , Offi c e o f P e st i cide Pr ogr am s , U n ited S t a te s En vironment a l Pro tect ion Agen c y. A vailable a t !t.np :/Iv.v.w .e p a. Q: ov/o p pefed l lmo del sl wate r/pca ad justme nt d \va.pdf (Acce ssed N .. v e mbe r 2 9 , 20 10) . U SE PA. 20 1Oc . 

### G u ida nce on D evelopm e nt a nd Us e of th e I nde x R ese rv oir i n D rinking Water Expo sure A s ses smen t s. September 14 , 2010. E nvironme nta l Fate an d E ff e c ts D ivi sion . O ffic e of Pes ticid e P ro gram s. U n ited S tates Env i r o nmental P rotection Age ncy . A v a ilable a t hn p: llw\vv.

_ epa. Qov /o ppefed l /models/waterl ind e x r e se r\ ' oir dwa. txlf ( Ac ces se d D ecember 9 , 

### c O lO ). U SNLM . 2009 . T O X \JET T o xicol ogy D ata N etw ork. U n ited Stat e s Na tio n al Library o f Medic in e (U SN LM). Avai lable a t hn p: l/toxne t. nlm.nih .Qov l ( Access ed J ul y 9 , 2 009) . Z h ao . X .• H ickey . R . F.• & 

### V o ice, T . C . 1999 . Lon g -term ev aluati o o f ad so rpti on cap acit y in a b io logical a c tivate d c ar bo n flui dized bed reac to r s yste m . 

### Wat er R es ear c h. 3 3( 13).

12

### Append ix A . En vironm ental Fate S um ma ry T abl e A 1. S u mm ary o f ph ysical-chemical prop ert ies of acetamiprid

P AR AM ET ER VA L UE SOU RC I<: C om m e nts P C Co de 09 9050 N o n e No ne CA S N u mber**135 10** **-20** ( USN LM , 2009) N one S tructu re 

# -0- / H , No n e el e -N 

# j H , "e -e H N 

# I ' N- e N C h emical Nam e N 1**~[(** 6 -ch t o r o - 3

- pyrid y l)me thy I]

- N 2

- cy a n o- N I MR ID 4465 1 8 03 N o n e meth yl a cet am idine M o l ec u lar W e ig h t 222 . 68 MRID 44 65 1803 N one W ate r S olu bility 4 250 m gl L (25 °C) MRID 4 465 1 81 1 No n e

Va por Pressu r e < I x 10 . 8 T orr a t 25°C M RID : 4 623570 1 N onvolatile from dry no n-adsorbing su rf ac es ( USE PA , 2 0 10a) 7.5 0 x 10. 1 0 T orr a t 25 °C (A E RU , 200 9 )

I X 10. 4 m Pa a t 2 5°C 5. 2 x 10. 14 atrn -m 'z

mo l a t 25 °C ' (L s nmated tro m vapor ' C arc uter eo wn n vapor p r essu r e p re ss ur e r ep orte d b y A E RU ( 20 09 ). H

enr y' s L aw c onstant ( estimated ) a n d w a ter s o lubi li ty a t p H 7 an d 20 °C) Di s s ociatio n C o nstant (p Ka) 0. 7 a t 25°C ( USEP A , 2002) N one L

o g K o w 0 .8 a t 25 °C M RID 446 5 188 3 N o t likely t o bio co n ccn tra r e ( US EPA , 2 0 l Oa) 

### 1 3

### <I, 

# t e, 

# '" '" ::> ::> 

# - - · 0 

# - " • 

## a 

# - • • · 0 

# .. § 0 0 0

0 

## § 0 

# '" N N 

# '" .;; 0 

# " > "0 

## § > Z 

## § Z



# - '" 

# - - 0 

## .,- N 0 

# - - " n X 

# • 8 < 

# '" '" N 

# " " B 0 0



### - N 0 0 

# '" 0 

# -

- - x x X M 

## '" 

# - 0 N 

## - M N

### Table A 2. Summary of environ mental fate an d transport pr operties of acctamipr id Parame ter Va l ue(s) S o u rce S iudy C c nnn ent C l assifica t ion I l y d rolys i s Half-l i fe , li nea r regression : MRID Accep t able MRID 446 5 18 17 i s unac ceptable . S tab le (p I! 5, 7 , 9 a t 2 5 °C) 4 465 1 876 50 . 8 d ays (p H 9 at 35 °C) 1 2 . 8 d ay s ( p fl9 at 4 5 ° C) Atmo s pheric lI a lf · l if e : (US EPA , NA E stimat ed U s ing E PIWeb Vers ion 4 . 0 D e gradation 0 . 140 day s ( e sti mated) 20 09a) A queou s Half-life , lin ear r eg ressio n : MRID A cceptable NOlie Photo l ysis I la lf· 3 4 d a ys 2(p H 7 , 25 °C) 44988 509 l if

e So il Ph oto lys i s N o acce ptab l e dat a a va il able NA N A MRID 4498 8508 i s u n acceptab le . I la lf ·life A erob ic So il Ha lf-life , n onli near r egress ion at 20 ° C : MRID S up ple menta l

- Only o ne r ep l ica te . Uncxrracted re si d ue s made up 0 .23

- M etaboli sm Half

- 4 625560 3 N ot for u s e in 3 1 .3 1 % o f app lied radi oactivity . l if

e (day s) Par ent O nly : mo deling 1 . 1 , s an d y l oam 1.2, clay loam 1.0 , clay lo am P arent - Unextrac ted Re s idues 7 6 , s andy loam 7 5, clay l o a m 9 9 , cl ay l oam Hal f-life , n on l inear reg re ss ion at 20° C : M RID Sup p lementa l Prev iou s ri sk a ssess ment s h owe d re su lt s w ith v ar i ou s model s. 446 5188 1 f orei gn s o il s. U n exr ra c ted r e si du es m ade up a s ign i fi ca nt P ar e nt Onlv : , ,,n ,, ,, n l 

### "r "nnl i ... ,1 " I 11 , ... ...", 1 

### " r II. ..**~1"'** t" n nr " " imM ..l v 

### ?n

_ 2 JI , s a ndy l oam 0 .90, s i lt y clay lo am 6 , clay l oam P

are nt + Une x t racted Re s idue s: 10 , c lay lo am 4 0 % at 18 2 da ys ); h owever, une xrract ed re si dues were n o t o b s erved until m ost of the p arent had al ready deg raded in the s ilty c lay l oam and s and y loa m . Thi s indi cates that the un

extrac rcd res idue s were n ot t h e p arent comp o und . U nex tracte d re s idues in the cla y loa m app eared a s the parent wa s lo s t a nd it i s 1I0 t a s e asy t o d e t e rmine wh e ther th e unextra ct ed re s idu e s w e re the paren t o r not . 

### 15

### Pa rame ter Va luc (s) S o u rce S lu dy Co mm e nt C lass ifi cat ion H a lf

- li fe , n onl inea r reg res s ion at 2 0 °C: M RID S uppleme nta l Foreig n s o i l s . Une xtractcd re sidu e s r an g ed f rom 1.9-16 . 8 % 4469 910 1 o f app lied r a d ioac t iv it y . Th e i de ntity o f th e u nex tractcd Par e nt O n ly : re s i du e s i s not k nown . 1 . 4 , loam y s and P arent -Unex tra c t ed Re s idue s: 

# , 2 . 0, lo am y s an d 

## , Hal f

- lif e , l inear reg re ssio n at 2 5°C: MR ID Supple ment a l , S up plementa l beca us e o f th e us c o fa fore i gn s oi l (C o l lo mb ey 

### O

J , loam y s and 4 465 1880 Not f or u sc in Gra n d , YS /Swi tze r land ) an d w a s 11 0t co nduct ed u nder G L P. mode lin g B a sed o n th e US DA g ui d e for tex tural cla ss ification , t he s oi l w a s c h ar act e rize d a s a loa m y s an d a n d w a s s im ila r t o s o ils fo u nd in th e U . S . Uncxtra c t cd r e s idues w e re a max im um of 14 % in the fi nal s a m p li ng int er val and le ss th an 10% i n previo us s a m pli n g interval s . Ha lf

- lif e, linea r regre ss i on aI 25 ° C : M RID Accep tab l e Previou s r isk a sse ssment wa s cond ucted us ing r e gi st r ant 44 6 5 18 79 calcula t ed h al f

- lif e usin g a s ub s e t o f d at a (0- 3 1 day s). P are nt O n ly : B ipha s i e degradat ion w a s o b served w ith a n in itial 3 .6 d ay 3 .5 , loa m y s and half-life f o llo we d b y a 7 5 d ay h a lf -lif e . P arent + Unextrac t ed Re s id u e s: 6 .4 , l o amv s a nd Aero bi c Aquat ic Half

- lif e . n onl i n ear re g ress ion' at M RID A cceptable Maximu m o f 3 8 % une xtrac r cd re sid ue s . It i s n ot known M e tabo li sm lI a l f - 25 ° C : P are n t O n ly : 449 88 513 w hethe r un ext r ac t cd re s idue s w e re paren t. l if

e ( days) 25 , l o am y sa nd s e dim ent P are nt -s U ne xtrac t ed Re s idue s : 

### 7' loam y s and s ediment An aerobic Aqu a tic Half -life , line ar re g re ssio n a t 25° C: M RID Acce pta b le P reviou s ri s k a ss ess ment re po rted an o b s e rved half-life of3 65 Me tab ol i sm Half

- 3 25 , l oam y s and s edi m ent 4 4988 5 12 da y s b ecau se 

### 5 1 . 5% w as still prese nt 

### ill on e rep lic at e at th e life ( da ys) e n d of th e s tu dy ( 36 3 day s).



### 1 6Pa r am eter Va lue(s) S ource S t udy Co m men t C l assificatio n So lid

- wate r Av erage K d at 2 0 "C M R ID Co e ffici ent of variat ion is 6 6% , d i s trib ut i on 4 4 651 883 c oefficient (K d ) i n 0 . 39, lo amy s and , p H 4 . 4 U kg 3. 9, loam s and 11 , p H 6 .2 1.1 , s i lt loa m , p H 6 .6 3 . 5 , cla y , p 1l 7 . 5 4 . 1 , sa n dy lo am s e dim ent , p H 5 . 6 M ean = 2 . 60 ( standa r d dev iation =I . 72) Fr

eundli c h s o l id

- K 

### d lin) at 20 "C 

### MR ID Acce ptable Freu nd lic h exp onent s i n di ca te that s o rp tio n w as dep e nd ent o n wate r di s tr ibut io n 4 46 5 188 3 c oncen tra tion i n s o me s oi ls . c o efficient ( K F ) in P arent: Uk g 0 .3 3 (0 .85 ) , loa m y s a nd, p 1l 4.4 3 . 0 (0.8 2), loa m s a nd II , p H 6 . 2 1 . 0 (0.90) , s i lt loam , pH 6 .6 3 .2 (0.9 1), cl ay , p H 7 .5 3 .2 (0 .83) , s andy lo am s ediment, o H 5 .6 O r ga ni c- ca rbo n A v erag e K oc at 20 " C M RID Accep table C o e fficient o f va ria tion i s 2 8% . T he c oefficient of va riatio n n o rm al iz ed 4 465 1 883 i s le ss th an that f or Kd val ues in d i

c atin g tha t Koc val ue s w i ll d is tr ibut i on 157 , loamy s an d, p1 1 4 .4 b e b et t e r at p redict in g s orp ti o n acro ss s oi ls th a n K d v a lue s . c oeffi ci ent (K oc ) Mo d eratel y mob il e acco rdin g t o FAD cla ss ificat ion . in l A g-D C 266 , lo a m s and II , p H 6 .2 2 51 , si ll lo am , p H 6 . 6 2 98 , cl ay, p H 7. 5 164 , s an dy lo a m s ediment, p H 5.6**~Il** .. ..... "" ." .,**"n..l "r..l** **..l ;,:,** **:t :!** **';** T e rr e s tr i al F ie ld Ha lf

- life, n on l inear re g re ssio n : M RID S up plemental Dc gradatc I M -I- 2 c o nvert e d t o IM -I -4 in sto r a ge s tability D i ssipati on Half

- 2 .8, C A , G ilman loam y fine , V inc a rosea 44 988 51 4 s tu d y a nd I M- J

-4 was no t s tab le. Re s idue s in p lant s were n ot li fe ( day s ) 14 .1 , FL , A s tatu la fi ne , tre e ferns re ported . Br oadca s t li t 0 . 15 lb s a.i.za c re w ith f our 4 .2 , N J , P e nn s i lt loam , ga rden m ums appli c ati ons . P arent w a s no t d e tected be low IS e m .



### 1 7Parameter Value(s) S ource S tudy C omment Cla ssificat ion Ha lf-lif e , l in e ar r eg ress io n : M RID Su ppl e me nt al De gradate IM - I- 2 c onver ted t o I M

- I -4 in s torage s tability 3 , WA , T imerman coa rse sa ndy lo am, 449 885 15 s tud y a n d IM -1-4 was n o t stable . Residues in p lants w e re n o t a pples r eport ed . B roa dc ast at 0. 15 lb s a.l.z acre w ith fo ur 6 , FL, C and ler s and soil , orange s ap plicatio ns. P a r

en

t wa s n o t de te cted b elow 15 em . 13 , NY , O akville lo amy fine sa nd , C o n diti ons n ot fa vorable to leaching . S ubse t o f da ta u sed t o c abbage esti mate hal f

- l if e f o r F L an d W A si te . ' (} , L/\, i{ uJIlUlld lu , i il l s U l i , cu t te n Hal f-life , lin ear regression : MRJD Su pp lemen t a l P an ev aporation d ata were n ot r eported so w ater b alances 10.1 , Prin ce Edward Islan d , Al berry s a n dy 44 988625 c ould n ot be dete rm ined . S torage s tab i l it y d ata were no t loam s ubmi tted f or the test si te so ils . Ace tam iprid wa s ap plied four 5 . 2 , On tar io , Lo ndon loam ti mes at 1 68 g a .i ./h a w ith a 7 d ay in t e r va l t o ba re p lot s in 1 7 .8, M anitoba , Ryerson cla y l oam Canad a. P are nt not d etected b elow 1 5 C lll dep th . Abb rev iations : ECM = En vironmenla l Chem istry M ethod; IL Vein de pendent la bo rato ry V alidatio n ' Degradatio n k inetic s wer e ca lculated u s in g t he s ingle fi rst order d ecay equat io n u sing e ithe r non lin ear re g re s sio n o f n o n - transformed data o r l inear reg ress ion o f n atural log transfo rm ed data . 2V a lue co rrected to re prese nt natural s u nligh t a t 4 0 ' N l ati t u d e .



### 18

### Table A 3. S ummary of environmenta l fate and tran sport properti es of 6- chl oronicotinic acid, a degradate of a cetamiprhl P a ram eter Va lue(s) S ource S tudy Co mment C lass ifi c a tio n Ae r o bic Soi I Half-lif e, l i near reg re ss ion : MRID Supple menta l B riti sh s o ils and U SDA cl a ssi fi cati on c ou ld n ot b e M et ab oli sm H alf- 44 651882 de t erm ined . Unextracted r e sidues r a n ged f ro m 3 . 1- l if

e 2 . 5 d ay s ( sa ndy lo am s o il a t 2 0 " C) 2 0 .7 % o f ap pl ied radioa ctiv it y . Half-live s c alculat ed 1 . 7 d ay s (c lay s oil at 2 0 "C) u s ing a s ubset of d ata f o r cl ay a nd l o a m s o i l s . 6 .6 d ay s ( loa m s oil a t 2 0 " C) Solid

- wate r A vera g e K , in U kg a t 2 0 " C : MR ID Ac ce p ta bl e di st ribution 4465 1884 c oefficie nt ( Kd ) 0,4 4, l oam y s an d , p I! 4 .4 0 . 83, l o am s a n d II , p H 6 .2 0 .28, s ilt l oam , p I! 6 . 6 0 .28, clay, p1l 7.5 2 .3 6 s an dy l o am se d ime n t, 0 11 5 .6 Fr

eu ndlich so li d- K F in I J kg ( l I n ) a t 2 0 "C: 

### MRID A ccep t able Fr e u nd lic h ex ponent s indica te th at s o rp t i o n was wa t e r di s tr ibution 44 65188 4 d epe n den t on co nce nt ra t io n i n s o m e s o ils . coe ffici en t ( K F) 0 .40 ( 0 . 9 1) , loam y s a nd . p i I 4 ,4 0 . 79 ( 1. 0) , l oam s a n d II , p H 6 .2 0 . 26 ( 0 .94 ) , s i lt l oam, p H 6 . 6 0 . 19 (0 . 8 2) , cla y, pH 7 . 5 1 . 8 1 (0 .86) , s a ndy lo am sed iment , p H 5 . 6 Or ganic-carbo n A ve r ag e KO(' in I J kg D C at 20 " C : 

### MRID Acceptable No ne n or mali zed 4 4651884 d istr i bu tion 177 , loam y s a nd, pH 4.4 c oe ffici e nt ( KOC) 56 , l oam s a n d II , p H 6.2 64 , s ilt l oa m, p l l 6.6 3 4 , cla y , p 1 1 7 . 5 

### 94 s and v loam se diment , o H 5. 6



# - -----

1 9

### Appendix B. FlRS l M odeling Output file

RUN N o . 1**FO** ac e t a pmi p ri d O N s o yb e a n .. INP UT VAL UES .. RATE ( # / AC )

O NE ( M UL T) No .APPS & INT ERV AL S OI L K

o c SO LUB I L ( P PM ) APPL TYPE ( %DR I IT) ," CRO P PED IN CORP AREA ( I N) 0 .0 40 ( 0 .0 60) 2 7 22 7 . 04 25 0 . 0 AERIAL ( 1 6. 0) 1 0 0 . 0 0 . 0

F I ELD AND RES : ':RV O IR HALF LI F E VALUES ( DA YS) ME TABOL I C ( F I ELD )**~S** UNT IL RAI::t !RUNOFF HYDROLY SI S ( RE S E RVOIR) P HOTOL Y SI S ( RES .- E F F ) ME T A BOL IC ( RES E R. ) C OM BI NED ( R E S E R . ) 7 . 0 0 2 0 .0 0 34 . 0 0 - 4 2 1 6 . 0 0 222 . 00 21 0.9 0 UNTREATE D**WAT :R**  C O NC ( M I CR OG RAM S / L I T ER ( P P B» Ver 1 . 1 . 1 MAR 26 , 2 0 0 8 PEAK D AY ( A CUT E )**CO RA** **T IO** 3 . ' 15 2 ANNUAL AVERAGE ( C HRON I C) C ON CENTRATI ON 1.13 5

RUN N o . 2 F llR acetamip rid O N s oybean .. IN PUT V AL UES .. RATE ( #/ A C )

ONE ( M ULT ) NO .APPS & I NTERVA L S OIL S OLUBIL A PP L TYPE Koc ( P PM ) ( %DRI FT) '"CR O P PED IN C O RP AREA ( I N ) 0 .0 40( 0.06 0 ) 2 7 227.0 4 2 5 0 . 0 GROUND ( 6 . 4) 10 0.0 0 .0

F I ELD AND RES : ; :RVO IR HALF LI FE VAL UES ( DAYS) METAB OLIC

( F IELD) 7 . 0 0**~S** UNTIL RA nr /RUN OFF 2 HY DROLYS I S ( RES ERVOIR) N

/A PH OTO LYSI S ( RE S.

- EFF ) 34 . 0 0 - 42 16 . 0 0 ME TABOLIC ( RES E R. ) 2 2 2. 00 COMBI NED ( R E S E R. )

21 0 .9 0 UNT REAT ED WAT : :R C ONC ( M I CROG RAM S /LI T E R ( P P B)) Ver 1 .1 .1 MAR 2 6, 20 0 B PEAK DAY ( ACUT E ) CONCE N" ' RAT IO N 3 . :0 4**~~ AL**  AVERAGE ( CHR ONI C ) CO NC ENT RAT I ON 1. 0 7 4

RUN N o . 3 F l lR acetami p r id ON c l o v e r .. INPUT VALUES .. 

## 20RA TE ( # / AC) O

NE ( MULT ) N o .A PPS & I NTER VA L S OIL S O LU8 1 L APPL TYPE K

oc (P P M) (\D RI F T) % I :: ROP PE D I NCORP AREA ( I N) 0.07 5( 0 . 07 5) 1 1 2 27 . 0 4 2 50 . 0 AER IAL (16 .0 ) 1. 0 0 .0 0.0

FIE LD AND RES ERV O IR HAL F LI FE V ALUES ( D AY S ) METABOL I C

( FI ELD ) D A

Y

S UNT IL RAI N / RUN OFF HYD R O

LYSI S ( RES ER VO I R ) P H OTOL YSIS (R ES .

- EF F ) M ETAB ) L IC (RES E L ) CO MB I NED (R E S ER. ) 7 . 00 2 N /A 3 4 .0 0- 4 21 6 . 0 0 2 22 . 00 2 10 . 9 0 UNTREAT E D W ATER CO N

C ( MI CR OG RAM S/ LI T ER ( P P B» V e r 1 . 1 . t MAR 26 , 2 008 P EAK D A

Y ( ACUT E) CONCE NTRATI ON 4 . 7 9 2 ANNUAL A VERAGE ( CH RO NI C) CO NCENT RA TI O N 1.36 8

R

UN No . 4 FO R a c e ta mi p r i d 

### O N cl over 9 • : NPUT VALUES • RAT E ( #/ AC) ONE ( M U

L T ) N o . APPS & I NTERVAL SO I L 

### R

o c S OLUBI L (P PM ) AP PL T YPE (%- DRI FT) \ . : R OP PE D I N CORP AR E

A ( I N ) 0 . 07 5( 0 . 07 5) 1 1 227 . 0 4 2 50 . 0 GRANUL ( 0 .0) . 00 . 0 0 . 0

FI ELD AND R E S ERV O I R HA L FLIF E V AL UES ( D AY S) M

ETAB OL I C ( F I ELD) DA YS UNT I L RA I N / R UNOF F HYDROLY SI S ( RES E R VO I R) P HOT O LYSIS ( RE S . - E FF ) M ETABO L I C**RES ~.)**  CO MB I NED ( RESER. )



# - -- -- - - -- - - ---- ---- -- - -- -- -- - - - --- - ---- - - - ---- --- - - - - - . _ - -- - --- ----- 7.00 2 N /A 3 4 . 00 - 4 21 6 . 00 2 22 . 0 0 2 1 0.9 0 UNrREATE D W A

TER CO NC ( MI CR OG RAM S/ LI TER ( PPB» V e r 1 . 1 . 1 MAR 2 6 , 2 0 08



# - --- - - -- - - -- - - --- -- - -- - --- -- --- - - -- - - - - - - --- ---- -- -- -- - --- - ------- - PE AK D A

Y ( ACUT E ) CO N

CENTRATI O N 4 . 557 ANNUAL A VERAGE ( CH R

O

NI C) CO NCENTRA TI ON 1. 271

RUN N o . 

### 5 F O

R a cetam i p ri d 

### O N g r a pes 

### * : . NP UT V ALUES •



# - -- -- - - - - -- -- - - - --- - -- ------- - -- -- - --- ------ --- -- - - - -- 

# -- - -- -- --- - --

RATE ( #/ A C) O

N

E ( MULT ) N O . APP S & INT E R VAL S OIL 

### R

o c S O LUB IL 

### ( P P M ) APPL T YPE (%DR IF T) \: l :ROPPE D I N CORP AR E

A (I N)



### 2 10 . 10 0 ( 0. 12 5 ) 2 1 4 2 27.0 4 2 5 0 . 0 A ERI AL ( 1 6 .0 ) 10 0 . 0 0 .0 F I ELD AND RE S3RV OIR HALF LIF E VAL UES ( D AY S) METABO LI C DA £ S UNT IL HYD R OLY SI S ( FI E LD) RA I t

J / RUN OFF ( RESER VO I R) P H O

TOLYS I S ( RE S. -EFF ) METAB OLI C ( RESER. ) COMB I NED ( RESE R. ) 7. 00 2 N !A 3 4. 00 - 4 2 1 6 . 00 222 . 0 0 2 1 0 .9 0 UNTREAT ED WA ! 3 R CO NC ( MI CR OG RAM S/ L I T E R ( PP B» Ver 1 .1 . 1 MAR 26 , 2008 PEAK D A

Y ( A CUT E) CO NCEK f RA TIO N 8 . l22 ANNU AL A VE RAGE ( CHR O

NI C) CO N

C ENT RA TI O N 2 .43 0

RUN N o . 

### 6 F )R 

### a c etami p r id O N grapes * I NPUT VALUE S 

### * RATE ( #/ A C) ONE ( M ULT) N o .AP PS & I NTERVAL S OIL 

### K

oc SO L UB I L 

### ( PP M ) APP L TYPE ( \ DRI FT) ,"CR O

PP ED INC ORP A

REA ( I N) 0. 1 00 ( 0 . 125 ) 2 14 22 7 . 0 4 25 0 . 0 G RANUL ( 0 . 0 ) 1 00 . 0 0 . 0 FI ELD 

### AND RES ERV O I R HALF LI FE V ALUES ( DAY S ) METAB OLI C

( FI ELD) D ll 

### i s UNTIL RA I N /RUNO FF HY DR O

LY SI S ( RESER VO IR ) P HOT OL Y

SI S ( RE S . - EFF ) M E

TABOLI C ( RE S ER . ) CO MBI NED ( RESER . ) 7.0 0 2 N ! A 3 4 . 00 - 4 2 1 6 . 0 0 2 22 . 00 2 10.90 UNTR EATED WA 'I'1 3R CO NC ( MI C RO G RAM S/LIT ER ( PP B» Ve r 1 . 1 . 1 MAR 26, 20 08 PE AK DA Y ( A CUTE) CO NCEK :' RA TI O N 7 . 59 4 ANNUA L A VERAGE ( CH RO NIC) CO N

CENTRA T I ON 2 .118

RUN N o . 

### 6 F J R 

### a c e tam ipr id O N gr ee n ho us e '" I NPUT V ALUE S 

### * RATE ( #! A CI

ONE ( MULT) N o . APPS 

### & I NTERV AL S O I L 

### K

oc SOLUB I L 

### ( PPM I APPL TYPE ( \ DRI FT) \C R O

PPED IN COR P AREA (I N ) 0. 07 S( 0. 13 1 ) 2 3 22 7 . 0 4 2 5 0 . 0 GR O

UND ( 6 .4 ) 1 00 .0 0 .0 F I ELD AND**RV OI**  HALF LI FE V ALUES ( D A

Y

S) 

### 22M ETABOLIC (FIELD) DAYS UNTIL RA I N/ RUNOFF HYDROLYSIS ( RESER VOIR) PHOTOLYSIS ( RES . - EFF ) META b: )LIC ( RES ER. ) CO MBINED ( RESER . ) 7.00 2 

### N /A 3 4.00

- 4216 . 0 0 22 : : .00 21 0 .9 0 UNTREATED WATER CO NC ( MI CR OG RAM S/ LI TE R ( PPB» V e r 1 . 1 1 MAR 2 6, 200 8 PEAK DAY ( ACUT E) CONCE NTRATION 8 .232 ANNUAL AVERAGE ( CHRONI C) CONC ENTRATI ON 2. 3 2 1

RUN N o . 7 FOR acetam iprid 

### O N citru s 

### * I NPUT VALUES 

### * RATE ( #/ A C) O

NE ( MULT) No . APPS & IN TERVAL SOIL Koc SOLUBIL ( PP M ) APPL TYP E ('DR IFT )**-: P P E**  I NCORP AREA ( I N) 0. 2 50( 0.37 5 ) 2 7 22 7 . 0 4 25 0 . 0 AERIAL (1 6 . 0 ) 100.0 0.0

FIELD AND RESERVOI R HALFLIFE VALUES ( DA YS) METAB O LIC ( FIELD) DAYS UNTIL RA I N /RUNOFF HYDROLYS I S ( RESE RVOIR) P HOTOLYSIS ( RES .

- E FF ) METAE \lJLIC**(RESE :~**  ) C O

M

BI NED (R ESER . ) 7 .00 2 

### N / A 34 .00- 4 2 1 6 . 0 0**22** . 0 0 210 .90 UNTREATE D WATER CO NC ( MI CROG RAM S / L ITE R ( PPB» Ver 1 . 1 . 1 

### MAR 2 6 , 200 8 PEAK DA Y ( ACUTE) CO NCE NTRAT IO N

24 . 6 9 7 ANNUAL AVERAGE ( CHRONIC) CO NCENTRATION 7 .0 9 3

RUN N o . 8 FOR ace ta m ip r i d 

### O N cit rus g * INPUT VALUES 

### *



# - --- - ---- --- --- --- -- ---- ---- - -- --- - -- -- -- ------ -- --- -- - - -- - ------- --

RAT E ( #/ A C) O

NE ( MU L

T) No.APPS 

### & I NTE RVA L SO IL S OL UBIL APPL TYPE K

oc (PP M) ( \-DRI FT) % ::;

R

OPPED I NCORP AREA ( IN)



# - - - - ----------- -- --- - ---- - -- - -- -- -- ---- ---- - -- ---- - -- -- - -- - --- ------ 0. 250 ( 0. 375) 2 7 22 7 . 0 4 2 5 0 . 0 GRANUL ( 0 .0 ) 100.0 0 .0

FIELD AND RESER VO I R HALFLIFE VALUES ( DA YS)



# -- ------------ - -- ---- ---- - --- ----- ---- --- -- --- --- -- - ---- - --- ----- --- METABO LIC

( FI ELD ) DAYS UNTIL RA I N/RUNOF F HYDROLYSIS (RE SERVO I R) PH OTOL YSIS ( RES . - EFF ) METAE J LIC ( RESE lL) CO MB INED ( RESER . )



# - --- --- -- ------ -- ---- -- ------ ---- ---- -- - ----- --- --- - - -+ --- ------ --- - 237.00 2 N / A 34 . 00 - 4 2 1 6 . 0 0 222 . 00 2 1 0 .90 UNTR EATED**WA T~R**  CONC ( M I CROGRAM S/ LI T E R ( P P B» V er 1.1 .1 MAR 26 , 2 0 08 PEAK D A Y ( ACUT E) CONCEN': RATI ON 2 2 . - , 83 ANNUAL AVERAGE ( CHRONI C ) CO NCENTRAT IO N 6 . 35 4

RUN N o . 9 F C·R acetam iprid 

### O N tree n ut s * INPUT VALUES 

### * RATE ( # / AC)

ONE ( MULT) No . AP PS & INTERVAL S OIL 

### K

oc S OLUBIL ( PPM ) APPL TYPE (\ DRI FT) \ CROP PED IN CORP AREA ( I N) 0 . 1 80( 0. 2 39 ) 4 14 22 7 . 0 425 0 . 0 AERIAL (1 6 . 0 ) 100.0 0.0

F IELD AND RES I : RVOIR HAL F LI FE VALUES ( DAYS) METAB OLI C

( F I ELD) 7 .0 0**DA~** UNTI L RAn "! RUNO F F 2 HYDROLYSIS (RES ERV O IR ) N

/ A P HOTOLYSI S ( RE S.

- E F F) 3 4 . 00

- 4 2 1 6 . 0 0 METABOLI C ( RES E R.) 222 . 0 0 CO MBI NED ( RES ER . )

21 0.9 0 UNTREA T ED W AT1: R CONC ( M I C R OGRAM S/ L I T E R ( P P B») Ver 1. 1. 1 MAR 26, 2 008 PEA K DAY ( ACUT E) CONCEN: 'RAT IO N**17 .S**  ANNU AL AV ERAGE ( CHRONI C)

CO NC ENTRAT ION 5 .286

RUN N o . 1 0 F : IR ace tami p r i d 

### O N t ree nuts 

### * I NPUT VALUES 

### * RATE ( #/ AC)

O N E ( M UL T) NO . APPS & INTERVAL SO IL 

### K

oc S O LUB I L ( PPM ) APP L TY PE ( \ DRI IT) ,"CROPPED I NCORP AREA ( I N) 0. 1 80( 0. 2 3 9 ) 4 1 4 227. 0 4 2 5 0 . 0 GRANUL ( 0.0) 1 0 0 . 0 0 .0

F I ELD AND**RE SJ~VOIR**  HAL FLI FE VALUES ( DA YS) METAB OLIC

( F I ELD) 7.00 DA"S UNTIL RA I Ii /RUN OFF 2 HYDR OLYSIS ( RE S ERVOI R) N

/ A PH OT OLYSIS ( RE S.

- E F F ) 34 . 0 0

- 4 216 . 0 0 METABOLI C ( RES ER .) 22 2.00 COM B INED ( RES E R. )

21 0 .9 0 UNTREATED WAT J : R CO NC ( MI CR OO RAM S/ L I T ER ( P PB» Ver 1 . 1.1 !of.AR 26 , 2 0 0 8 

## 24P EAK D AY ( ACUTE) CON CENTRATI ON 14 . 524 ANNUAL AVERAGE ( CHRON IC ) CO NCENT RATIO N 4.0 5 1

RUN N o . 1 1 FOR acecam i p rid ON p oCa Co '" I NPUT V ALUES '" RA TE ( #/ AC) O

NE (MUL T) No.A PPS & INT ERVAL SOIL 

### Koc SO L UBI L ( PPM ) AP PL TYPE ( " D RI FT ) t CROP PED IN CORP AREA (I N ) 0 .07 5 ( 0 . 20 3 ) 4 3 22 7 .0 4 2 5 0 . 0 AERIAL (l 6. 0 ) 1 0 0 .0 0 .0

FI ELD AND RESER V OIR HAL FLIF E VALUES ( DAY S) METABO LI C

(FIE LD) 7.0 0 DAY S UNTI L RAIN /RUN OFF 2 HYD ROLYSIS ( RES ERVOI R) N

/ A PH OTOLYSI S ( RES . - EF F ) 3 4 . 0 0- 4 2 1 6 . 0 0 META H JL IC**ES :~**  )**22~** .00 C OMB INE D ( RES ER .)

2 1 0 .9 0 UNTREAT ED WATER C ONe ( M I CROG RAM S / L I T E R ( P P B» Ve r 1 .1 . 1 MAR 26 , 2008 PE AK D AY ( A CUTE) C

ONCENTRATIO N 13 .5 36 ANNUAL A VERAGE ( CHRO NI C) CO NCENTRA TIO N 3 . 8 9 8



## 25

### Appendix C . S CIG I :OW Modeling Outpu t File S CI ( ,R OW VER : :IO N 2 . 3 E NVIRON M I : N T A L F ATE A ND EFF ECTS DIVISION O FFIC E 0 ' P ESTI CIDE PROGRAM S U .S. E NVIRO NM EN TAL PROT E CTIO N A G E N CY S CRE E NING MODEL FOR AQU i ,T IC P E STI CIDE EXPOSURE 

### SciGrow version 2.3 c hemical . acetamipri d 

### time i s 711 5/ 20 1 

### I ' :25:13 Application N um ber of Tota l Us e Koc Soi l A erobic 

### rate (lb/acre) appli ca tion s (lb /acre /yr) 

### (mllg) metabo lism (day s) 0.040 2 . 0 0.080 2.5 I E+ 02 5 .6 

### groundwa ter 

### scre enirg co nd ( ppb) = 

### 4. 1 5£ -04 * *********************************************************************** 

### S ciGrow v ersion 2 .3 chemica l .acetamiprid 

### t ime i s 7 / 15 / 20 1 

### I ' . : 25:28 Appl ication N un: b er o f Total U s e Koc Soi l Aerobic r ate (lb/acre) app lica t io ns 

### (l b /acre/yr ) (mllg ) met aboli sm ( days) 

### 0.075 1. 0 

### 0 .075 2.5 IE +02 5.6 

### g roundwater 

## s cree nir g c ond (ppb) = 

### 3 .89 E - 04******************************~********************************************************** * * * ****** * * *** 

### S c i Grow v ersion 2.3 c hem i cal : acetami pr i 

### c time i s 711 5 /2 011 , :25:45 App lication N urr ber 

### of Tota l U s e Ko c S oil Aerob ic 

### rate (lb/aer e) applic iti on s (lb /acre/ yr) (m l /g) 

### metabolism ( day s ) 0 . 100 

### 2. 0 0.200 2 .5 I E+0 2 5 .6 

### groundwa ter s cree ni r 

### g c ond (ppb) = 

### 1.04E-03**************************~********************************************************* * * *** 

## 26

### Sc i Grow v ersion 2 .3 

### chemi caka cetamiprid 

### time i s 7 / 1 512 0 11 8 : 2 5: 57 

### A pp lication N umber of Tota l Use K oc Soil A erobic 

### rate (lb/ac re) app l icatio n s (I b/ac r eiy r) ( mllg) m etaboli sm (d ays) 0 .G7 5 2 . 0 0.150 2.5 I 

### E +02 5 .6 g ro undwate r s creening co nd ( ppb) = 

### 7 .7 8£ · 04********************************************************************************************* ****** ****** *** 

## •• * Sc iGrow ver sion 2 .3 c h e mica l :ac e tamip rid 

### time is 7115 /2011 

### 8 :26 : 6 Ap plication N wnbe r o f To tal Use Koc So i l Ae r obic 

### rate (lb /acre ) applicati o n s (l b/acreiyr) (m llg) metaboli sm ( days) 0.25 0 2. 0 0 . 500 2 . 5 I E +0 2 5 .6 gr

oundwater sc reening c ond (Ppb) = 

### 2 .59£ -03 * ******** ****** ******** • •• *.* • ••• * •• *.* ••• • • ** •• •••• ** ••***.** 

## •• • •••• • •• •• Sc i G row v ersion 2 .3 che m ical :acetam iprid 

### time is 7115 12011 8 :26 :16 A pplication N u m be r o f To tal U se K oc Soil Aero bic 

### rate ( l b/ac re) ap plicatio n s (lb/ acre/yr ) ( m llg) m etabolism ( day s) 0 . 180 4 .0 

### 0 .720 2.5 I 

### E +02 5 .6 g r

ou nd water s c reening co nd ( ppb) = 

### 3 . 74 £ - 03 ***** • • * ••• * •••• * • • • • •• • • • • *• • • •••• • • • •• * •••• ••••• *** ••• • *. " •• ••••• • • • *. 

### SciG r ow version 2 .3 c hemical : acetam iprid 

### ti me i s 711 512 0 1 1 8 :26 :31 Ap plication N umbe r o f To tal U s e 

### Ko c So i l A erob ic 

### r a te (lb/acre) applicatio n s ( Ibia creiyr ) ( m llg) metabo li sm ( day s) 0 . 0 7 5 4 .0 

### 0.300 2 .5 I 

### E +02 5 .6

2 7

### groundwater sc ree ni r g cond (ppb) = 

### 1. 56£ - 03 **********   **  * t* ** ******* ** ******* ********* ****** ******** ************



### 2 8