Support Documents for 

Significant New Use Rule (SNUR) on 

Premanufacture Notice (PMN) 

P-11-580 

EPA Docket EPA-HQ-OPPT-2011-0942 

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Index 

A-001 Structure Activity Team (SAT) Report for 

 PMN P-11-580 

A-002 Initial Review Engineering Report for 

 PMN P-11-580 

A-003 Initial Review Exposure Report for 

 PMN P-11-580 

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A-001 

Structure Activity Team (SAT) Report 

for PMN P-11-580 

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SAT Report

PMN Number: P-11-0580

SAT Date: 8/23/2011

Print Date: 10/3/2011

Related cases:

Health related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 3

 Persistence Bioaccum Toxicity Comments

1 21

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Dermal Inhalation 

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: IRR-E,MM,L, NEURO, AQUATOX-A,C

Summary of Assessment:

 Fate:

Fate Summary: P-11-0580

FATE: 

Liquid with MP < 25 C (E)

log Kow = 5.61 (E); 

S = 2.4 mg/L at 25 C (E)

VP = 0.022 torr at 25 C (E, NOMO5)

BP = 259 C (NOMO5) based on 135-140 C @ 14 mm(M)

H = 2.08E-4 (E)

log Koc = 2.95 (E)

log Fish BCF = 3.37 (E)

log Fish BAF = 3.75 (E) 

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POTW removal (%) = 90 via sorption

Time for complete ultimate aerobic biodeg = wk-mo

Sorption to soils/sediments = strong

Volatilization half-life from a standard river = 6 hrs

Volatilization half-life from a standard lake = 8 da

Atmospheric Oxidation Half-life = 5 hr via OH radical

PBT Potential: P1B2

*CEB FATE: Migration to ground water = negl

 Health:

 Health Summary: Absorption is moderate all routes based on 

physical/chemical properties. There is concern for irritation to the eyes, lungs, and mucous 

membranes and concern for solvent neurotoxicity. Low moderate concern. 

 Ecotox:

Test 

Organism

Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 0.11 or *

daphnid 48-h LC50 0.083 or *

green algal 96-h EC50 0.10

fish _ chronic value 0.015

daphnid _ chronic value 0.021

algal _ chronic value 0.14

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for neutral organic chemicals; 

SAR chemical class = alcohol; MW 226; log Kow = 5.61 (EPI); liquid with mp = unknown (P); 

S = 2.4 mg/L at 25 C (P); pH7; effective concentrations based on 100% active ingredients and 

nominal concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

2

SARs neutral organic chemiicals

SAR Class alcohol new chemicals category: neutral 

organics

Ecotox Factors Comments: 

 SAT Chair: Becky Jones

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A-002 

Initial Review Engineering Report 

for PMN P-11-580 

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INITIAL REVIEW ENGINEERING REPORT 

PMN: 11-0580

Focus Ready Draft 9/1/2011

ENGINEER: Austin \ AH

PV (kg/yr): 25,000 Import Only

SUBMITTER: Eastman Kodak Co

USE: Chemical intermediate for a coupler for imaging

products. Synthetic sequence: P-11-578 -> P-11-0579 +

P-11-580 -> P-11-581 -> P-11-582 -> P-11-583 (ER,

P-03-628).

OTHER USES:

MSDS: Yes Label: No

Gen Eqpt: Safety glasses with side shields (or goggles),

impervious gloves and protective clothing

Respirator: NIOSH-approved with an APF of 1,000

Health Effects: Causes eye irritation. May be harmful if

inhaled, absorbed through skin, or swallowed. High vapor

concentrations may cause drowsiness and irritation of the

eyes or respiratory tract.

TLV/PEL:

Not established.

CRSS :

Chemical Name: Cyclohexanol, 2,6-bis(1,

1-dimethylethyl)-4-methylS-H20: 0.0024 g/L @

VP: 2.2E-2 torr @

MW: 226.00 %<500 %<1000

Physical State and Misc CRSS Info:

Neat: Liquid Mfg: Liquid Proc/Form: NA End Use: Destroyed.

 Submitted Data: Liquid; WS = 0.007 g/L (Sub.Est.). A

particle size of 15.22 microns is provided, but this

appears to be in error, since the substance is a liquid.

Literature Data (STN eProp): BP = 135-140°C at 14 torr.

Estimated Data (NOMO5 with BP entered as 135°C at 14

torr): BP = 258.9°C at 760 torr; VP = 0.022 torr.

Estimated Data (EPI with MP = 20°C): WS = 0.00235 g/L;

log P = 5.61; BP = 277.06°C; VP = 0.000552 torr.

Estimated Data (STN/ACD Labs): WS = 0.0059 g/L; log P = 5.

437; BP = 269.9°C; VP = 0.0009.37 torr.

Consumer Use: No

SAT (concerns) (08/23/2011):

Migration to groundwater: Negligible

PBT rating: P1B2T1

Health: 1-2 Dermal, Inhalation

Eco: 3 Water (All releases to water with a CC = 2ppb)

OCCUPATIONAL EXPOSURE RATING: 2A

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NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER. 

 

 

 

 

 

POLLUTION PREVENTION CONSIDERATIONS:

None.

EXPOSURE-BASED REVIEW: No

INITIAL REVIEW ENGINEERING REPORT 

PMN: 11-0580

Use: 

Number of Sites/ Location: 1

Eastman Business Park Rochester NY 14652

Days/yr: 42

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

IRER Note: The daily releases listed for any source below

may coincide with daily releases from the other sources

to the same medium.

Air

Typical: 8.0E-5 kg/site-day over 42 days/yr from 1 site

Worst Case: 1.6E-4 kg/site-day over 42 days/yr from 1 site

Air

Output 2: 2.6E-6 kg/site-day over 42 days/yr from 1 site

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Incineration

Output 2: 5.2E+1 kg/site-day over 42 days/yr from 1 site

or 2.2E+3 kg/yr

 

Landfill

High End: 1.8E+1 kg/site-day over 42 days/yr from 1 site

or 7.5E+2 kg/yr

RELEASE TOTAL

2.9E+3 kg/yr - all sites

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 3

Inhalation:

Exposure to Vapor (Class II)

Typical: 3.8E-2 mg/day over 42 days/yr

Worst Case: 2.3E+0 mg/day over 42 days/yr

Number of workers (all sites) with inhalation exposure: 3

 

 

 

Dermal:

Exposure to Liquid at 100.00% concentration

High End: 1.8E+3 mg/day over 42 days/yr

Number of workers (all sites) with dermal exposure: 3

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A-003 

Initial Review Exposure Report 

for PMN P-11-580 

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Page 1 of 1 

 

POST FOCUS EXPOSURE REPORT 

Release information for this compound does not meet criteria for preparation of an exposure assessment; 

were eliminated and the were below the threshold for exposure 

assessment 

Assessor: 

 

ENVIRONMENTAL RELEASES 

Scenario#: Number of Release Sites: 

Release Activity: 

Release Description: WATER LANDFILL INCINER LAND/INCIN FUGITIVE 

Total Releases: 

 

(kg/yr) (kg/yr) (kg/yr) (kg/yr) (kg/yr) 

Release Days/yr: 

 

Per Site Release: 

(kg/day) (kg/yr) (kg/yr) (kg/yr) (kg/day) 

Remarks: EAB DROP: Release information for this compound does not meet criteria for preparation 

of an exposure assessment in the Exposure Assessment Branch=s (EAB) Initial Review 

Exposure Report (this report). 

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